Photo of Prof Philip Rudland

Prof Philip Rudland MA, PhD, FRCPath, FIBiol, FRSA

Professor Biochemistry

    Biography

    Personal Statement

    I was a PhD student from 1967-1971 in the Laboratory of Molecular Biology working on the initiation of bacterial protein synthesis in Francis Crick and Sydney Brenner's Divison of Molecular Genetics. I then spent 3 years at the Salk Institute as a Helen Hay Whitney Fellow working in Renato Dulbecco and Bob Holley's Labs where I co-discovered the fibroblast growth factors (FGFs) with Denis Gospodarowicz and investigated their mechanism of action. I returned to England as Staff Member at Imperial Cancer Research Fund under Renato Dulbecco and Michael Stoker and used the FGFs to isolate the first reported breast stem lines from rat and later from human sources. From 1979-1986 I was Head of Department of Cell and Molecular Biology at the Ludwig Institute in Surrey, where I isolated and characterised further rat and human benign and malignant breast cell lines and related them to the development of the breast and the pathology of breast cancer. For this I was awareded MRCPath by Research. From 1986 I have been Professor of Biochemistry in Liverpool University and used my cell lines to codiscover with Roger Barraclough the Metastasis-Inducing Proteins (MIPs). From 2000-date I demonstrated enhanced occurrence of MIPs is associated with early demise of breast cancer patients and with Roger Barraclough some of their mechanisms of action, induction and 3D structures with colleagues in Liverpool. Unlike the oncogenes of Renato Dulbecco and his followers, our MIPs do not form tumours but cooperate with the oncogenes to promote many of the common cancers to metastasise. Thus I have been lucky in my career to shed some light on this murky but life threatening aspect of cancer, with the hope that our molecular discoveries will lead to improvements in diagnosis and treatment of the commonly-occuring cancers in the future.

    Personal Distinctions

    • Lecture - Breast Cancer Metastasis (Invitation to Speak, CMBF Dalian China 2009)
    • Lecture - Breast Cancer Metastasis (Invitation to Speak, Chinese Cancer Society 2009)
    • Lecture - Breast Cancer Metastasis (Invitation to Speak, BIT Beijing China 2009)
    • Lecture - Breast Cancer Metastasis (Invitation to Speak, Cancer Congress of China 2009)
    • Role of metastagenes in breast cancer (Invitation to Speak, BIT Life Sciences, China 2008)
    • Detection and Markers for Metastasis (Invitation to Speak, Breast Cancer Campaign 2006)
    • Lecture on Metastasis in Breast Cancer (Invitation to Speak, Medical Faculty, University of Belfast 2006)
    • Keynote Opening Lecture: Molecular mechanisms of metastasis. (Invitation to Speak, National Cancer Research Institute 2006)
    • Lecture on Isolation of metastasis-inducing genes and their potential role in breast cancer (Invitation to Speak, Medical Faculty, University of Liverpool 2005)
    • Lecture on Breast Cancer Metastasis (Invitation to Speak, Cancer Institute, Rio de Janeiro 2004)
    • Lecture on Osteopontin and breast cancer metastasis (Invitation to Speak, North West Cancer Reseaerch Fund, Liverpool 2003)
    • Honorary Senior Fellow (Hanah Research Institute 2003)
    • Lecture on Isolation of metastasis-inducing genes and their potential role in breast cancer (Invitation to Speak, Faculty of Medicine, University of East Anglia, Norwich 2002)
    • Lecture on Isolation of metastasis-inducing genes and their potential role in breast cancer (Invitation to Speak, School of Biological Sciences, University of Liverpool 2002)
    • Lectures on Discovery of metastasis-inducing genes in breast cancer (Invitation to Speak, Qingua and Shen Zhen Universities 2002)
    • Honorary Senior Fellow (Hanah Research Institute 2002)
    • Lecture on Regulatory Region of Metastasis-inducing DNA is the binding site for T Cell Factor 4 (Invitation to Speak, International Meeting for Osteopontin Research 2002)
    • Lecture on Isolation of metastasis-inducing genes and their potential role in breast cancer (Invitation to Speak, MRC Wellcome Trust Centre, Addenbrookes Hospital, Cambridge 2002)
    • Lecture on Breast Cancer Metastasis (Invitation to Speak, 6th World Congress in Oncology 2001)
    • Honorary Senior Fellow (Hanah Research Institute 2001)

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