Dr Margaret Hughes BSc, PhD

Senior Research Assistant Biochemistry & Systems Biology

    Publications

    2021

    White pupae phenotype of tephritids is caused by parallel mutations of a MFS transporter (Journal article)

    Ward, C. M., Aumann, R. A., Whitehead, M. A., Nikolouli, K., Leveque, G., Gouvi, G., . . . Schetelig, M. F. (2021). White pupae phenotype of tephritids is caused by parallel mutations of a MFS transporter. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-020-20680-5

    DOI: 10.1038/s41467-020-20680-5

    2020

    Whole-Genome Sequence of Streptomyces kaniharaensis Shomura and Niida SF-557. (Journal article)

    Zhu, W., Liu, X., Hughes, M., de Crécy-Lagard, V., & Richards, N. G. J. (2020). Whole-Genome Sequence of Streptomyces kaniharaensis Shomura and Niida SF-557.. Microbiology Resource Announcements, 9(14). doi:10.1128/mra.01434-19

    DOI: 10.1128/mra.01434-19

    Large scale and significant expression from pseudogenes in Sodalis glossinidius - a facultative bacterial endosymbiont (Journal article)

    Darby, A. C., Goodhead, I., Blow, F., Brownridge, P., Hughes, M., Kenny, J., . . . Beynon, R. (2020). Large scale and significant expression from pseudogenes in Sodalis glossinidius - a facultative bacterial endosymbiont. Microbial Genomics, 6(1), 3-15. doi:10.1099/mgen.0.000285

    DOI: 10.1099/mgen.0.000285

    2019

    Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. (Journal article)

    Hope, W., Stone, N. R. H., Johnson, A., McEntee, L., Farrington, N., Santoro-Castelazo, A., . . . Bicanic, T. (2019). Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance.. mBio, 10(6). doi:10.1128/mbio.02575-19

    DOI: 10.1128/mbio.02575-19

    2018

    Draft Genome Assembly of the Poultry Red Mite, Dermanyssus gallinae. (Journal article)

    Burgess, S. T. G., Bartley, K., Nunn, F., Wright, H. W., Hughes, M., Gemmell, M., . . . Nisbet, A. J. (2018). Draft Genome Assembly of the Poultry Red Mite, Dermanyssus gallinae.. Microbiology resource announcements, 7(18). doi:10.1128/MRA.01221-18

    DOI: 10.1128/MRA.01221-18

    Draft Genome Assembly of the Sheep Scab Mite, Psoroptes ovis. (Journal article)

    Burgess, S. T. G., Bartley, K., Marr, E. J., Wright, H. W., Weaver, R. J., Prickett, J. C., . . . Nisbet, A. J. (2018). Draft Genome Assembly of the Sheep Scab Mite, Psoroptes ovis.. Genome announcements, 6(16). doi:10.1128/genomeA.00265-18

    DOI: 10.1128/genomeA.00265-18

    Genomics of habitat choice and adaptive evolution in a deep-sea fish (Journal article)

    Gaither, M. R., Gkafas, G. A., de Jong, M., Sarigol, F., Neat, F., Regnier, T., . . . Hoelzel, A. R. (2018). Genomics of habitat choice and adaptive evolution in a deep-sea fish. NATURE ECOLOGY & EVOLUTION, 2(4), 680-687. doi:10.1038/s41559-018-0482-x

    DOI: 10.1038/s41559-018-0482-x

    2017

    SMRT Gate: A method for validation of synthetic constructs on Pacific Biosciences sequencing platforms (Journal article)

    D'Amore, R., Johnson, J., Haldenby, S., Hall, N., Hughes, M., Joynson, R., . . . Hall, A. (2017). SMRT Gate: A method for validation of synthetic constructs on Pacific Biosciences sequencing platforms. BIOTECHNIQUES, 63(1), 13-20. doi:10.2144/000114565

    DOI: 10.2144/000114565

    2016

    Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach (Journal article)

    Aljabr, W., Touzelet, O., Pollakis, G., Wu, W., Munday, D. C., Hughes, M., . . . Hiscox, J. A. (2016). Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach. JOURNAL OF VIROLOGY, 90(10), 4876-4888. doi:10.1128/JVI.02349-15

    DOI: 10.1128/JVI.02349-15

    2015

    Molecular tools for studying the major malaria vector Anopheles funestus: improving the utility of the genome using a comparative poly(A) and Ribo-Zero RNAseq analysis (Journal article)

    Weedall, G. D., Irving, H., Hughes, M. A., & Wondji, C. S. (2015). Molecular tools for studying the major malaria vector Anopheles funestus: improving the utility of the genome using a comparative poly(A) and Ribo-Zero RNAseq analysis. BMC GENOMICS, 16. doi:10.1186/s12864-015-2114-z

    DOI: 10.1186/s12864-015-2114-z

    Phylogenomics of the killer whale indicates ecotype divergence in sympatry (Journal article)

    Moura, A. E., Kenny, J. G., Chaudhuri, R. R., Hughes, M. A., Reisinger, R. R., de Bruyn, P. J. N., . . . Hoelzel, A. R. (2015). Phylogenomics of the killer whale indicates ecotype divergence in sympatry. HEREDITY, 114(1), 48-55. doi:10.1038/hdy.2014.67

    DOI: 10.1038/hdy.2014.67

    2014

    Novel Host-Related Virulence Factors Are Encoded by Squirrelpox Virus, the Main Causative Agent of Epidemic Disease in Red Squirrels in the UK (Journal article)

    Darby, A. C., McInnes, C. J., Kjaer, K. H., Wood, A. R., Hughes, M., Martensen, P. M., . . . Chantrey, J. (2014). Novel Host-Related Virulence Factors Are Encoded by Squirrelpox Virus, the Main Causative Agent of Epidemic Disease in Red Squirrels in the UK. PLOS ONE, 9(7). doi:10.1371/journal.pone.0096439

    DOI: 10.1371/journal.pone.0096439

    Population genomics of the killer whale indicates ecotype evolution in sympatry involving both selection and drift (Journal article)

    Moura, A. E., Kenny, J. G., Chaudhuri, R., Hughes, M. A., Welch, A. J., Reisinger, R. R., . . . Hoelzel, A. R. (2014). Population genomics of the killer whale indicates ecotype evolution in sympatry involving both selection and drift. MOLECULAR ECOLOGY, 23(21), 5179-5192. doi:10.1111/mec.12929

    DOI: 10.1111/mec.12929

    2013

    Characterisation of the genomes of four putative vesiculoviruses: tench rhabdovirus, grass carp rhabdovirus, perch rhabdovirus and eel rhabdovirus European X (Journal article)

    Stone, D. M., Kerr, R. C., Hughes, M., Radford, A. D., & Darby, A. C. (2013). Characterisation of the genomes of four putative vesiculoviruses: tench rhabdovirus, grass carp rhabdovirus, perch rhabdovirus and eel rhabdovirus European X. ARCHIVES OF VIROLOGY, 158(11), 2371-2377. doi:10.1007/s00705-013-1711-x

    DOI: 10.1007/s00705-013-1711-x

    2012

    Analysis of gene expression from the Wolbachia genome of a filarial nematode supports both metabolic and defensive roles within the symbiosis (Journal article)

    Darby, A. C., Armstrong, S. D., Bah, G. S., Kaur, G., Hughes, M. A., Kay, S. M., . . . Makepeace, B. L. (2012). Analysis of gene expression from the Wolbachia genome of a filarial nematode supports both metabolic and defensive roles within the symbiosis. GENOME RESEARCH, 22(12), 2467-2477. doi:10.1101/gr.138420.112

    DOI: 10.1101/gr.138420.112

    Genome Sequence for "Candidatus Mycoplasma haemominutum," a Low-Pathogenicity Hemoplasma Species (Journal article)

    Barker, E. N., Darby, A. C., Helps, C. R., Peters, I. R., Hughes, M. A., Radford, A. D., . . . Tasker, S. (2012). Genome Sequence for "Candidatus Mycoplasma haemominutum," a Low-Pathogenicity Hemoplasma Species. JOURNAL OF BACTERIOLOGY, 194(4), 905-906. doi:10.1128/JB.06560-11

    DOI: 10.1128/JB.06560-11

    2011

    Molecular characterization of the uncultivatable hemotropic bacterium Mycoplasma haemofelis (Journal article)

    Barker, E. N., Darby, A. C., Helps, C. R., Peters, I. R., Heesom, K. J., Arthur, C. J., . . . Tasker, S. (2011). Molecular characterization of the uncultivatable hemotropic bacterium Mycoplasma haemofelis. VETERINARY RESEARCH, 42. doi:10.1186/1297-9716-42-83

    DOI: 10.1186/1297-9716-42-83

    A De Novo Expression Profiling of Anopheles funestus, Malaria Vector in Africa, Using 454 Pyrosequencing (Journal article)

    Gregory, R., Darby, A. C., Irving, H., Coulibaly, M. B., Hughes, M., Koekemoer, L. L., . . . Wondji, C. S. (2011). A De Novo Expression Profiling of Anopheles funestus, Malaria Vector in Africa, Using 454 Pyrosequencing. PLOS ONE, 6(2). doi:10.1371/journal.pone.0017418

    DOI: 10.1371/journal.pone.0017418

    2010

    A Comprehensive Genetic Analysis of Candidate Genes Regulating Response to Trypanosoma congolense Infection in Mice (Journal article)

    Goodhead, I., Archibald, A., Amwayi, P., Brass, A., Gibson, J., Hall, N., . . . Noyes, H. A. (2010). A Comprehensive Genetic Analysis of Candidate Genes Regulating Response to Trypanosoma congolense Infection in Mice. PLOS NEGLECTED TROPICAL DISEASES, 4(11). doi:10.1371/journal.pntd.0000880

    DOI: 10.1371/journal.pntd.0000880

    Identification of Three Novel Superantigen-Encoding Genes in Streptococcus equi subsp zooepidemicus, szeF, szeN, and szeP (Journal article)

    Paillot, R., Darby, A. C., Robinson, C., Wright, N. L., Steward, K. F., Anderson, E., . . . Waller, A. S. (2010). Identification of Three Novel Superantigen-Encoding Genes in Streptococcus equi subsp zooepidemicus, szeF, szeN, and szeP. INFECTION AND IMMUNITY, 78(11), 4817-4827. doi:10.1128/IAI.00751-10

    DOI: 10.1128/IAI.00751-10

    Identification of Three Novel Superantigen-Encoding Genes in Streptococcus equi subsp. zooepidemicus, szeF, szeN, and szeP (Journal article)

    Paillot, R., Darby, A. C., Robinson, C., Wright, N. L., Steward, K. F., Anderson, E., . . . Waller, A. S. (2010). Identification of Three Novel Superantigen-Encoding Genes in Streptococcus equi subsp. zooepidemicus, szeF, szeN, and szeP. Infection and Immunity, 78(11), 4817-4827. doi:10.1128/iai.00751-10

    DOI: 10.1128/iai.00751-10

    Characteristics of the genome of Arsenophonus nasoniae, son-killer bacterium of the wasp Nasonia (Journal article)

    Darby, A. C., Choi, J. -H., Wilkes, T., Hughes, M. A., Werren, J. H., Hurst, G. D. D., & Colbourne, J. K. (2010). Characteristics of the genome of Arsenophonus nasoniae, son-killer bacterium of the wasp Nasonia. INSECT MOLECULAR BIOLOGY, 19, 75-89. doi:10.1111/j.1365-2583.2009.00950.x

    DOI: 10.1111/j.1365-2583.2009.00950.x

    2009

    Application of ESTs in microarray analysis. (Journal article)

    Li, W., Olohan, L., Williams, D., Hughes, M., Gracey, A., & Cossins, A. (2009). Application of ESTs in microarray analysis.. Methods in molecular biology (Clifton, N.J.), 533, 289-309. doi:10.1007/978-1-60327-136-3_14

    DOI: 10.1007/978-1-60327-136-3_14

    Expressed Sequence Tags (ESTs) (Chapter)

    Expressed Sequence Tags (ESTs) (2009). Humana Press. doi:10.1007/978-1-60327-136-3

    DOI: 10.1007/978-1-60327-136-3

    2008

    Genomic resources and microarrays for the common carp Cyprinus carpio L. (Journal article)

    Williams, D. R., Li, W., Hughes, M. A., Gonzalez, S. F., Vernon, C., Vidal, M. C., . . . Cossins, A. R. (2008). Genomic resources and microarrays for the common carp Cyprinus carpio L.. Journal of Fish Biology, 72(9), 2095-2117. doi:10.1111/j.1095-8649.2008.01875.x

    DOI: 10.1111/j.1095-8649.2008.01875.x

    Genomic resources and microarrays for the common carp Cyprinus carpio L. (Journal article)

    Williams, D. R., Li, W., Hughes, M. A., Gonzalez, S. F., Vernon, C., Vidal, M. C., . . . Cossins, A. R. (2008). Genomic resources and microarrays for the common carp Cyprinus carpio L.. JOURNAL OF FISH BIOLOGY, 72(9), 2095-2117. doi:10.1111/j.1095-8649.2008.01875.x

    DOI: 10.1111/j.1095-8649.2008.01875.x

    2007

    Single gene differentiation by DNA-modified carbon electrodes using an AC impedimetric approach (Journal article)

    Davis, F., Hughes, M. A., Cossins, A. R., & Higson, S. P. J. (2007). Single gene differentiation by DNA-modified carbon electrodes using an AC impedimetric approach. ANALYTICAL CHEMISTRY, 79(3), 1153-1157. doi:10.1021/ac061070c

    DOI: 10.1021/ac061070c

    Salinity adaptation and gene profiling analysis in the European eel (Anguilla anguilla) using microarray technology (Journal article)

    Kalujnaia, S., McWilliam, I. S., Zaguinaiko, V. A., Feilen, A. L., Nicholson, J., Hazon, N., . . . Cramb, G. (2007). Salinity adaptation and gene profiling analysis in the European eel (Anguilla anguilla) using microarray technology. GENERAL AND COMPARATIVE ENDOCRINOLOGY, 152(2-3), 274-280. doi:10.1016/j.ygcen.2006.12.025

    DOI: 10.1016/j.ygcen.2006.12.025

    2006

    Post-genomic approaches to understanding the mechanisms of environmentally induced phenotypic plasticity (Journal article)

    Cossins, A., Fraser, J., Hughes, M., & Gracey, A. (2006). Post-genomic approaches to understanding the mechanisms of environmentally induced phenotypic plasticity. JOURNAL OF EXPERIMENTAL BIOLOGY, 209(12), 2328-2336. doi:10.1242/jeb.02256

    DOI: 10.1242/jeb.02256

    2005

    Seasonally hibernating phenotype assessed through transcript screening (Journal article)

    Williams, D. R., Epperson, L. E., Li, W. Z., Hughes, M. A., Taylor, R., Rogers, J., . . . Gracey, A. Y. (2005). Seasonally hibernating phenotype assessed through transcript screening. PHYSIOLOGICAL GENOMICS, 24(1), 13-22. doi:10.1152/physiolgenomics.00301.2004

    DOI: 10.1152/physiolgenomics.00301.2004

    1997

    Zebedee?: A novel copia-Ty1 family of transposable elements in the genome of the medically important mosquito Aedes aegypti (Journal article)

    Warren, A. M., Hughes, M. A., & Crampton, J. M. (1997). Zebedee?: A novel copia-Ty1 family of transposable elements in the genome of the medically important mosquito Aedes aegypti. Molecular and General Genetics MGG, 254(5), 505-513. doi:10.1007/s004380050445

    DOI: 10.1007/s004380050445