Photo of Dr Dan Rigden

Dr Dan Rigden BA, PhD

Reader in Post-Genomic Bioinformatics Biochemistry

    Publications

    Selected Publications

    1. AMPLE: a cluster-and-truncate approach to solve the crystal structures of small proteins using rapidly computed ab initio models (Journal article - 2012)
    2. Applications of contact predictions to structural biology (Journal article - 2017)
    3. Routine phasing of coiled-coil protein crystal structures with AMPLE (Journal article - 2015)
    4. Structure- and context-based analysis of the GxGYxYP family reveals a new putative class of Glycoside Hydrolase (Journal article - 2014)
    5. The 24th annual Nucleic Acids Research database issue: a look back and upcoming changes. (Journal article - 2017)

    2018

    Autophosphorylation Is a Mechanism of Inhibition in Twitchin Kinase (Journal article)

    Williams, R. M., Franke, B., Wilkinson, M., Fleming, J. R., Rigden, D. J., Benian, G. M., . . . Mayans, O. (2018). Autophosphorylation Is a Mechanism of Inhibition in Twitchin Kinase. JOURNAL OF MOLECULAR BIOLOGY, 430(6), 793-805. doi:10.1016/j.jmb.2018.01.020

    DOI: 10.1016/j.jmb.2018.01.020

    Candidate-gene based GWAS identifies reproducible DNA markers for metabolic pyrethroid resistance from standing genetic variation in East African Anopheles gambiae (Journal article)

    Weetman, D., Wilding, C. S., Neafsey, D. E., Muller, P., Ochomo, E., Isaacs, A. T., . . . Donnelly, M. J. (2018). Candidate-gene based GWAS identifies reproducible DNA markers for metabolic pyrethroid resistance from standing genetic variation in East African Anopheles gambiae. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-21265-5

    DOI: 10.1038/s41598-018-21265-5

    Ensembles generated from crystal structures of single distant homologues solve challenging molecular-replacement cases in AMPLE (Journal article)

    Rigden, D. J., Thomas, J. M. H., Simkovic, F., Simpkin, A., Winn, M. D., Mayans, O., & Keegan, R. M. (2018). Ensembles generated from crystal structures of single distant homologues solve challenging molecular-replacement cases in AMPLE. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 74, 183-193. doi:10.1107/S2059798318002310

    DOI: 10.1107/S2059798318002310

    Genome-wide transcriptional analyses in Anopheles mosquitoes reveal an unexpected association between salivary gland gene expression and insecticide resistance (Journal article)

    Isaacs, A. T., Mawejje, H. D., Tomlinson, S., Rigden, D. J., & Donnelly, M. J. (2018). Genome-wide transcriptional analyses in Anopheles mosquitoes reveal an unexpected association between salivary gland gene expression and insecticide resistance. BMC GENOMICS, 19. doi:10.1186/s12864-018-4605-1

    DOI: 10.1186/s12864-018-4605-1

    Large scale ab initio modeling of structurally uncharacterized antimicrobial peptides reveals known and novel folds (Journal article)

    Kozic, M., Fox, S. J., Thomas, J. M., Verma, C. S., & Rigden, D. J. (2018). Large scale ab initio modeling of structurally uncharacterized antimicrobial peptides reveals known and novel folds. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 86(5), 548-565. doi:10.1002/prot.25473

    DOI: 10.1002/prot.25473

    Recent developments in MrBUMP: better search-model preparation, graphical interaction with search models, and solution improvement and assessment (Journal article)

    Keegan, R. M., McNicholas, S. J., Thomas, J. M. H., Simpkin, A. J., Simkovic, F., Uski, V., . . . Rigden, D. J. (2018). Recent developments in MrBUMP: better search-model preparation, graphical interaction with search models, and solution improvement and assessment. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 74, 167-182. doi:10.1107/S2059798318003455

    DOI: 10.1107/S2059798318003455

    The 2018 Nucleic Acids Research database issue and the online molecular biology database collection (Journal article)

    Rigden, D. J., & Fernandez, X. M. (2018). The 2018 Nucleic Acids Research database issue and the online molecular biology database collection. NUCLEIC ACIDS RESEARCH, 46(D1), D1-D7. doi:10.1093/nar/gkx1235

    DOI: 10.1093/nar/gkx1235

    2017

    Applications of contact predictions to structural biology (Journal article)

    Simkovic, F., Oychinnikov, S., Baker, D., & Rigden, D. J. (2017). Applications of contact predictions to structural biology. IUCRJ, 4, 291-300. doi:10.1107/S2052252517005115

    DOI: 10.1107/S2052252517005115

    Approaches to ab initio molecular replacement of alpha-helical transmembrane proteins (Journal article)

    Thomas, J. M. H., Simkovic, F., Keegan, R., Mayans, O., Zhang, C., Zhang, Y., & Rigden, D. J. (2017). Approaches to ab initio molecular replacement of alpha-helical transmembrane proteins. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 73, 985-996. doi:10.1107/S2059798317016436

    DOI: 10.1107/S2059798317016436

    ConKit: a python interface to contact predictions (Journal article)

    Simkovic, F., Thomas, J. M. H., & Rigden, D. J. (2017). ConKit: a python interface to contact predictions. BIOINFORMATICS, 33(14), 2209-2211. doi:10.1093/bioinformatics/btx148

    DOI: 10.1093/bioinformatics/btx148

    From Protein Structure to Function with Bioinformatics (Book)

    Rigden, D. (Ed.) (2009). From Protein Structure to Function with Bioinformatics. Dordrecht: Springer.

    Function Prediction Using Patches, Pockets and Other Surface Properties (Chapter)

    Rigden, D. J. (2017). Function Prediction Using Patches, Pockets and Other Surface Properties. In D. J. Rigden (Ed.), From Protein Structure to Function with Bioinformatics (pp. 327-360). Heidelberg: Springer.

    Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population (Journal article)

    Carr, D. F., Bourgeois, S., Chaponda, M., Takeshita, L. Y., Morris, A. P., Castro, E. M. C., . . . Pirmohamed, M. (2017). Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 72(4), 1152-1162. doi:10.1093/jac/dkw545

    DOI: 10.1093/jac/dkw545

    Glareosin: a novel sexually dimorphic urinary lipocalin in the bank vole, Myodes glareolus (Journal article)

    Loxley, G. M., Unsworth, J., Turton, M. J., Jebb, A., Lilley, K. S., Simpson, D. M., . . . Beynon, R. J. (2017). Glareosin: a novel sexually dimorphic urinary lipocalin in the bank vole, Myodes glareolus. OPEN BIOLOGY, 7(9). doi:10.1098/rsob.170135

    DOI: 10.1098/rsob.170135

    Novel compound heterozygous ASXL3 mutation causing Bainbridge-ropers like syndrome and primary IGF1 deficiency. (Journal article)

    Giri, D., Rigden, D., Didi, M., Peak, M., McNamara, P., & Senniappan, S. (2017). Novel compound heterozygous ASXL3 mutation causing Bainbridge-ropers like syndrome and primary IGF1 deficiency.. International journal of pediatric endocrinology, 2017, 8. doi:10.1186/s13633-017-0047-9

    DOI: 10.1186/s13633-017-0047-9

    Prediction of protein function from theoretical models (Chapter)

    Rigden, D. J., Cymerman, I. A., & Bujnicki, J. M. (2017). Prediction of protein function from theoretical models. In D. J. Rigden (Ed.), From Protein Structure to Function with Bioinformatics (pp. 467-498). Heidelberg: Springer.

    Probing Medin Monomer Structure and its Amyloid Nucleation Using C-13-Direct Detection NMR in Combination with Structural Bioinformatics (Journal article)

    Davies, H. A., Rigden, D. J., Phelan, M. M., & Madine, J. (2017). Probing Medin Monomer Structure and its Amyloid Nucleation Using C-13-Direct Detection NMR in Combination with Structural Bioinformatics. SCIENTIFIC REPORTS, 7. doi:10.1038/srep45224

    DOI: 10.1038/srep45224

    Structure and function of Per-ARNT-Sim domains and their possible role in the life-cycle biology of Trypanosoma cruzi (Journal article)

    Rojas-Pirela, M., Rigden, D. J., Michels, P. A., Caceres, A. J., Concepcion, J. L., & Quinones, W. (2018). Structure and function of Per-ARNT-Sim domains and their possible role in the life-cycle biology of Trypanosoma cruzi. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 219, 52-66. doi:10.1016/j.molbiopara.2017.11.002

    DOI: 10.1016/j.molbiopara.2017.11.002

    The 24th annual Nucleic Acids Research database issue: a look back and upcoming changes. (Journal article)

    Galperin, M. Y., Fernandez-Suarez, X. M., & Rigden, D. J. (2017). The 24th annual Nucleic Acids Research database issue: a look back and upcoming changes (vol 45, pg D1, 2017). NUCLEIC ACIDS RESEARCH, 45(9), 5627. doi:10.1093/nar/gkx021

    DOI: 10.1093/nar/gkx021

    2016

    Biophysical Analysis of the N-Terminal Domain from the Human Protein Phosphatase 1 Nuclear Targeting Subunit PNUTS Suggests an Extended Transcription Factor TFIIS-Like Fold (Journal article)

    Zacharchenko, T., Barsukov, I., Rigden, D. J., Bennett, D., & Mayans, O. (2016). Biophysical Analysis of the N-Terminal Domain from the Human Protein Phosphatase 1 Nuclear Targeting Subunit PNUTS Suggests an Extended Transcription Factor TFIIS-Like Fold. PROTEIN JOURNAL, 35(5), 340-345. doi:10.1007/s10930-016-9677-7

    DOI: 10.1007/s10930-016-9677-7

    CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex (Journal article)

    Zhou, T., Fleming, J. R., Franke, B., Bogomolovas, J., Barsukov, I., Rigden, D. J., . . . Mayans, O. (2016). CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex. FEBS LETTERS, 590(18), 3098-3110. doi:10.1002/1873-3468.12362

    DOI: 10.1002/1873-3468.12362

    Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I. (Journal article)

    Bogomolovas, J., Fleming, J. R., Anderson, B. R., Williams, R., Lange, S., Simon, B., . . . Mayans, O. (2016). Exploration of pathomechanisms triggered by a single-nucleotide polymorphism in titin's I-band: the cardiomyopathy-linked mutation T2580I. OPEN BIOLOGY, 6(9). doi:10.1098/rsob.160114

    GP0.4 from bacteriophage T7: in silico characterisation of its structure and interaction with E. coli FtsZ. (Journal article)

    Simpkin, A. J., & Rigden, D. J. (2016). GP0.4 from bacteriophage T7: in silico characterisation of its structure and interaction with E. coli FtsZ.. BMC research notes, 9, 343. doi:10.1186/s13104-016-2149-5

    DOI: 10.1186/s13104-016-2149-5

    Potential DNA binding and nuclease functions of ComEC domains characterized in silico (Journal article)

    Baker, J. A., Simkovic, F., Taylor, H. M. C., & Rigden, D. J. (2016). Potential DNA binding and nuclease functions of ComEC domains characterized in silico. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 84(10), 1431-1442. doi:10.1002/prot.25088

    DOI: 10.1002/prot.25088

    Residue contacts predicted by evolutionary covariance extend the application of ab initio molecular replacement to larger and more challenging protein folds (Journal article)

    Simkovic, F., Thomas, J. M. H., Keegan, R. M., Winn, M. D., Mayans, O., & Rigden, D. J. (2016). Residue contacts predicted by evolutionary covariance extend the application of ab initio molecular replacement to larger and more challenging protein folds. IUCRJ, 3, 259-270. doi:10.1107/S2052252516008113

    DOI: 10.1107/S2052252516008113

    Role of Peptidoglycan Deacetylase in Staphylococcus aureus Virulence and Survival (Thesis / Dissertation)

    Alorabi, J. A. (2016, April 5). Role of Peptidoglycan Deacetylase in Staphylococcus aureus Virulence and Survival.

    Structural and biochemical characterisation of the regulatory principles of Twitchin Kinase, a member of the titin-like family of muscle kinases (Thesis / Dissertation)

    Williams, R. M. (2016, September 30). Structural and biochemical characterisation of the regulatory principles of Twitchin Kinase, a member of the titin-like family of muscle kinases.

    The 2016 database issue of Nucleic Acids Research and an updated molecular biology database collection (Journal article)

    Rigden, D. J., Fernandez-Suarez, X. M., & Galperin, M. Y. (2016). The 2016 database issue of Nucleic Acids Research and an updated molecular biology database collection. NUCLEIC ACIDS RESEARCH, 44(D1), D1-D6. doi:10.1093/nar/gkv1356

    DOI: 10.1093/nar/gkv1356

    The Heparin-Binding Proteome in Murine Experimental Acute Pancreatitis (Journal article)

    Nunes, Q. M., Su, D., Brownridge, P. J., Sun, C., Li, Y., Huang, W., . . . Fernig, D. G. (2016). The Heparin-Binding Proteome in Murine Experimental Acute Pancreatitis. PANCREAS, 45(10), 1530. Retrieved from http://gateway.webofknowledge.com/

    The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability (Journal article)

    Heride, C., Rigden, D. J., Bertsoulaki, E., Cucchi, D., De Smaele, E., Clague, M. J., & Urbe, S. (2016). The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability. JOURNAL OF CELL SCIENCE, 129(21), 4001-4013. doi:10.1242/jcs.188516

    DOI: 10.1242/jcs.188516

    The industrial melanism mutation in British peppered moths is a transposable element (Journal article)

    van't Hof, A. E., Campagne, P., Rigden, D. J., Yung, C. J., Lingley, J., Quail, M. A., . . . Saccheri, I. J. (2016). The industrial melanism mutation in British peppered moths is a transposable element. NATURE, 534(7605), 102-+. doi:10.1038/nature17951

    DOI: 10.1038/nature17951

    2015

    ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei (Journal article)

    Brennand, A., Rico, E., Rigden, D. J., Van Der Smissen, P., Courtoy, P. J., & Michels, P. A. M. (2015). ATG24 Represses Autophagy and Differentiation and Is Essential for Homeostasy of the Flagellar Pocket in Trypanosoma brucei. PLOS ONE, 10(6). doi:10.1371/journal.pone.0130365

    DOI: 10.1371/journal.pone.0130365

    Contemporary evolution of resistance at the major insecticide target site gene Ace-1 by mutation and copy number variation in the malaria mosquito Anophelesgambiae (Journal article)

    Weetman, D., Mitchell, S. N., Wilding, C. S., Birks, D. P., Yawson, A. E., Essandoh, J., . . . Donnelly, M. J. (2015). Contemporary evolution of resistance at the major insecticide target site gene Ace-1 by mutation and copy number variation in the malaria mosquito Anophelesgambiae. MOLECULAR ECOLOGY, 24(11), 2656-2672. doi:10.1111/mec.13197

    DOI: 10.1111/mec.13197

    Exploring the speed and performance of molecular replacement with AMPLE using QUARK ab initio protein models (Journal article)

    Keegan, R. M., Bibby, J., Thomas, J., Xu, D., Zhang, Y., Mayans, O., . . . Rigden, D. J. (2015). Exploring the speed and performance of molecular replacement with AMPLE using QUARK ab initio protein models. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 71, 338-343. doi:10.1107/S1399004714025784

    DOI: 10.1107/S1399004714025784

    Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22 (Journal article)

    Sohn, Y. -S., Shin, H. -C., Park, W. S., Ge, J., Kim, C. -H., Lee, B. L., . . . Oh, B. -H. (2015). Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22. PLOS ONE, 10(3). doi:10.1371/journal.pone.0118683

    DOI: 10.1371/journal.pone.0118683

    Routine phasing of coiled-coil protein crystal structures with AMPLE (Journal article)

    Thomas, J. M. H., Keegan, R. M., Bibby, J., Winn, M. D., Mayans, O., & Rigden, D. J. (2015). Routine phasing of coiled-coil protein crystal structures with AMPLE. IUCRJ, 2, 198-206. doi:10.1107/S2052252515002080

    DOI: 10.1107/S2052252515002080

    Structural advances on titin: towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding (Journal article)

    Zacharchenko, T., von Castelmur, E., Rigden, D. J., & Mayans, O. (2015). Structural advances on titin: towards an atomic understanding of multi-domain functions in myofilament mechanics and scaffolding. BIOCHEMICAL SOCIETY TRANSACTIONS, 43, 850-855. doi:10.1042/BST20150084

    DOI: 10.1042/BST20150084

    The 2015 Nucleic Acids Research Database Issue and Molecular Biology Database Collection (Journal article)

    Galperin, M. Y., Rigden, D. J., & Fernandez-Suarez, X. M. (2015). The 2015 Nucleic Acids Research Database Issue and Molecular Biology Database Collection. NUCLEIC ACIDS RESEARCH, 43(D1), D1-D5. doi:10.1093/nar/gku1241

    DOI: 10.1093/nar/gku1241

    Transcriptomic Analysis of Shiga-Toxigenic Bacteriophage Carriage Reveals a Profound Regulatory Effect on Acid Resistance in Escherichia coli (Journal article)

    Veses-Garcia, M., Liu, X., Rigden, D. J., Kenny, J. G., McCarthy, A. J., & Allison, H. E. (2015). Transcriptomic Analysis of Shiga-Toxigenic Bacteriophage Carriage Reveals a Profound Regulatory Effect on Acid Resistance in Escherichia coli. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 81(23), 8118-8125. doi:10.1128/AEM.02034-15

    DOI: 10.1128/AEM.02034-15

    2014

    AMPLE: a cluster-and-truncate approach to solve the crystal structures of small proteins using rapidly computed ab initio models (vol 68, pg 1622, 2012) (Journal article)

    Bibby, J., Keegan, R. M., Mayans, O., Winn, M. D., & Rigden, D. J. (2014). AMPLE: a cluster-and-truncate approach to solve the crystal structures of small proteins using rapidly computed ab initio models (vol 68, pg 1622, 2012). ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 70, 1174. doi:10.1107/S1399004714006154

    DOI: 10.1107/S1399004714006154

    Conversion of a Disulfide Bond into a Thioacetal Group during Echinomycin Biosynthesis (Journal article)

    Hotta, K., Keegan, R. M., Ranganathan, S., Fang, M., Bibby, J., Winn, M. D., . . . Kim, C. -Y. (2014). Conversion of a Disulfide Bond into a Thioacetal Group during Echinomycin Biosynthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53(3), 824-828. doi:10.1002/anie.201307404

    DOI: 10.1002/anie.201307404

    Crystal Structure of the Nipah Virus Phosphoprotein Tetramerization Domain (Journal article)

    Bruhn, J. F., Barnett, K. C., Bibby, J., Thomas, J. M. H., Keegan, R. M., Rigden, D. J., . . . Saphire, E. O. (2014). Crystal Structure of the Nipah Virus Phosphoprotein Tetramerization Domain. JOURNAL OF VIROLOGY, 88(1), 758-762. doi:10.1128/JVI.02294-13

    DOI: 10.1128/JVI.02294-13

    Evidence for Loss of a Partial Flagellar Glycolytic Pathway during Trypanosomatid Evolution (Journal article)

    Brown, R. W. B., Collingridge, P. W., Gull, K., Rigden, D. J., & Ginger, M. L. (2014). Evidence for Loss of a Partial Flagellar Glycolytic Pathway during Trypanosomatid Evolution. PLOS ONE, 9(7). doi:10.1371/journal.pone.0103026

    DOI: 10.1371/journal.pone.0103026

    Extracellular calcium triggers unique transcriptional programs and modulates staurosporine-induced cell death in Neurospora crassa. (Journal article)

    Gonçalves, A. P., Monteiro, J., Lucchi, C., Kowbel, D. J., Cordeiro, J. M., Correia-de-Sá, P., . . . Videira, A. (2014). Extracellular calcium triggers unique transcriptional programs and modulates staurosporine-induced cell death in Neurospora crassa.. Microbial cell (Graz, Austria), 1(9), 289-302. doi:10.15698/mic2014.09.165

    DOI: 10.15698/mic2014.09.165

    Metabolic and Target-Site Mechanisms Combine to Confer Strong DDT Resistance in Anopheles gambiae (Journal article)

    Mitchell, S. N., Rigden, D. J., Dowd, A. J., Lu, F., Wilding, C. S., Weetman, D., . . . Donnelly, M. J. (2014). Metabolic and Target-Site Mechanisms Combine to Confer Strong DDT Resistance in Anopheles gambiae. PLOS ONE, 9(3). doi:10.1371/journal.pone.0092662

    DOI: 10.1371/journal.pone.0092662

    Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1 (Journal article)

    Franke, B., Gasch, A., Rodriguez, D., Chami, M., Khan, M. M., Rudolf, R., . . . Mayans, O. (2014). Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1. OPEN BIOLOGY, 4(3). doi:10.1098/rsob.130172

    DOI: 10.1098/rsob.130172

    Structural basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1 (Journal article)

    Franke, B., Gasch, A., Rodriguez, D., Chami, M., Khan, M. M., Rudolf, R., . . . Mayans, O. (2014). Structural basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1. Open Biology, 4, 130172.

    Structural genomics analysis of uncharacterized protein families overrepresented in human gut bacteria identifies a novel glycoside hydrolase (Journal article)

    Sheydina, A., Eberhardt, R. Y., Rigden, D. J., Chang, Y., Li, Z., Zmasek, C. C., . . . Godzik, A. (2014). Structural genomics analysis of uncharacterized protein families overrepresented in human gut bacteria identifies a novel glycoside hydrolase. BMC BIOINFORMATICS, 15. doi:10.1186/1471-2105-15-112

    DOI: 10.1186/1471-2105-15-112

    Structure- and context-based analysis of the GxGYxYP family reveals a new putative class of Glycoside Hydrolase (Journal article)

    Rigden, D. J., Eberhardt, R. Y., Gilbert, H. J., Xu, Q., Chang, Y., & Godzik, A. (2014). Structure- and context-based analysis of the GxGYxYP family reveals a new putative class of Glycoside Hydrolase. BMC BIOINFORMATICS, 15. doi:10.1186/1471-2105-15-196

    DOI: 10.1186/1471-2105-15-196

    The 2014 Nucleic Acids Research Database Issue and an updated NAR online Molecular Biology Database Collection (Journal article)

    Fernandez-Suarez, X. M., Rigden, D. J., & Galperin, M. Y. (2014). The 2014 Nucleic Acids Research Database Issue and an updated NAR online Molecular Biology Database Collection. NUCLEIC ACIDS RESEARCH, 42(D1), D1-D6. doi:10.1093/nar/gkt1282

    DOI: 10.1093/nar/gkt1282

    Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line (Journal article)

    Bogomolovas, J., Gasch, A., Simkovic, F., Rigden, D. J., Labeit, S., & Mayans, O. (2014). Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line. OPEN BIOLOGY, 4(5). doi:10.1098/rsob.140041

    DOI: 10.1098/rsob.140041

    2013

    Application of the AMPLE cluster-and-truncate approach to NMR structures for molecular replacement (Journal article)

    Bibby, J., Keegan, R. M., Mayans, O., Winn, M. D., & Rigden, D. J. (2013). Application of the AMPLE cluster-and-truncate approach to NMR structures for molecular replacement. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 69, 2194-2201. doi:10.1107/S0907444913018453

    DOI: 10.1107/S0907444913018453

    Correction: Evaluating Caveolin Interactions: Do Proteins Interact with the Caveolin Scaffolding Domain through a Widespread Aromatic Residue-Rich Motif? (Journal article)

    Byrne, D. P., Dart, C., & Rigden, D. J. (2013). Correction: Evaluating Caveolin Interactions: Do Proteins Interact with the Caveolin Scaffolding Domain through a Widespread Aromatic Residue-Rich Motif?. PloS one, 8(2). doi:10.1371/annotation/2c275a1b-2d36-4492-b36a-192bddf14f78

    DOI: 10.1371/annotation/2c275a1b-2d36-4492-b36a-192bddf14f78

    DEUBIQUITYLASES FROM GENES TO ORGANISM (Journal article)

    Clague, M. J., Barsukov, I., Coulson, J. M., Liu, H., Rigden, D. J., & Urbe, S. (2013). DEUBIQUITYLASES FROM GENES TO ORGANISM. PHYSIOLOGICAL REVIEWS, 93(3), 1289-1315. doi:10.1152/physrev.00002.2013

    DOI: 10.1152/physrev.00002.2013

    Deubiquitylases From Genes to Organism (Journal article)

    Clague, M. J., Barsukov, I., Coulson, J. M., Liu, H., Rigden, D. J., & Urbe, S. (2013). Deubiquitylases From Genes to Organism. Physiological Reviews, 93(3), 1289-1315. doi:10.1152/physrev.00002.2013

    DOI: 10.1152/physrev.00002.2013

    Employing in vitro directed molecular evolution for the selection of α-amylase variant inhibitors with activity toward cotton boll weevil enzyme. (Journal article)

    da Silva, M. C. M., Del Sarto, R. P., Lucena, W. A., Rigden, D. J., Teixeira, F. R., Bezerra, C. D. A., . . . Grossi-de-Sa, M. F. (2013). Employing in vitro directed molecular evolution for the selection of α-amylase variant inhibitors with activity toward cotton boll weevil enzyme.. Journal of biotechnology, 167(4), 377-385. doi:10.1016/j.jbiotec.2013.07.016

    DOI: 10.1016/j.jbiotec.2013.07.016

    Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling (Journal article)

    Clarke, M., Lohan, A. J., Liu, B., Lagkouvardos, I., Roy, S., Zafar, N., . . . Loftus, B. J. (2013). Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling. GENOME BIOLOGY, 14(2). doi:10.1186/gb-2013-14-2-r11

    DOI: 10.1186/gb-2013-14-2-r11

    Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family (Journal article)

    Mayans, O., Benian, G. M., Simkovic, F., & Rigden, D. J. (2013). Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family. BIOCHEMICAL SOCIETY TRANSACTIONS, 41, 1066-1071. doi:10.1042/BST20130085

    DOI: 10.1042/BST20130085

    Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family (Journal article)

    Mayans, O., Benian, G. M., Simkovic, F., & Rigden, D. J. (2013). Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family. Biochem Soc Trans, 41, 1066-1071.

    The first structure in a family of peptidase inhibitors reveals an unusual Ig-like fold. (Journal article)

    Rigden, D. J., Xu, Q., Chang, Y., Eberhardt, R. Y., Finn, R. D., & Rawlings, N. D. (2013). The first structure in a family of peptidase inhibitors reveals an unusual Ig-like fold.. F1000Research, 2, 154. doi:10.12688/f1000research.2-154.v1

    DOI: 10.12688/f1000research.2-154.v1

    Ubiquitination of the glycosomal matrix protein receptor PEX5 in Trypanosoma brucei by PEX4 displays novel features (Journal article)

    Gualdron-Lopez, M., Chevalier, N., Van der Smissen, P., Courtoy, P. J., Rigden, D. J., & Michels, P. A. M. (2013). Ubiquitination of the glycosomal matrix protein receptor PEX5 in Trypanosoma brucei by PEX4 displays novel features. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1833(12), 3076-3092. doi:10.1016/j.bbamcr.2013.08.008

    DOI: 10.1016/j.bbamcr.2013.08.008

    2012

    A new family of bacterial DNA repair proteins annotated by the integration of non-homology, distant homology and structural bioinformatic methods (Journal article)

    Mello, L. V., & Rigden, D. J. (2012). A new family of bacterial DNA repair proteins annotated by the integration of non-homology, distant homology and structural bioinformatic methods. FEBS LETTERS, 586(21), 3908-3913. doi:10.1016/j.febslet.2012.09.023

    DOI: 10.1016/j.febslet.2012.09.023

    AMPLE: a cluster-and-truncate approach to solve the crystal structures of small proteins using rapidly computed ab initio models (Journal article)

    Bibby, J., Keegan, R. M., Mayans, O., Winn, M. D., & Rigden, D. J. (2012). AMPLE: a cluster-and-truncate approach to solve the crystal structures of small proteins using rapidly computed ab initio models. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 68, 1622-1631. doi:10.1107/S0907444912039194

    DOI: 10.1107/S0907444912039194

    Evaluating Caveolin Interactions: Do Proteins Interact with the Caveolin Scaffolding Domain through a Widespread Aromatic Residue-Rich Motif? (Journal article)

    Byrne, D. P., Dart, C., & Rigden, D. J. (2012). Evaluating Caveolin Interactions: Do Proteins Interact with the Caveolin Scaffolding Domain through a Widespread Aromatic Residue-Rich Motif?. PLOS ONE, 7(9). doi:10.1371/journal.pone.0044879

    DOI: 10.1371/journal.pone.0044879

    Genomic determinants of sporulation in Bacilli and Clostridia: towards the minimal set of sporulation-specific genes (Journal article)

    Galperin, M. Y., Mekhedov, S. L., Puigbo, P., Smirnov, S., Wolf, Y. I., & Rigden, D. J. (2012). Genomic determinants of sporulation in Bacilli and Clostridia: towards the minimal set of sporulation-specific genes. ENVIRONMENTAL MICROBIOLOGY, 14(11), 2870-2890. doi:10.1111/j.1462-2920.2012.02841.x

    DOI: 10.1111/j.1462-2920.2012.02841.x

    Genomic determinants of sporulation: A minimal set of sporulation-specific genes in Bacilli and Clostridia (Journal article)

    Galperin, M. Y., Mekhedov, S. L., Puigbo, P., Smirnov, S., Wolf, Y. I., & Rigden, D. J. (2012). Genomic determinants of sporulation: A minimal set of sporulation-specific genes in Bacilli and Clostridia. Environmental Microbiology, 14, 2870-2890.

    Prediction of antimicrobial peptides based on the adaptive neuro-fuzzy inference system application (Journal article)

    Fernandes, F. C., Rigden, D. J., & Franco, O. L. (2012). Prediction of antimicrobial peptides based on the adaptive neuro-fuzzy inference system application. BIOPOLYMERS, 98(4), 280-287. doi:10.1002/bip.22066

    DOI: 10.1002/bip.22066

    Rab14 and Its Exchange Factor FAM116 Link Endocytic Recycling and Adherens Junction Stability in Migrating Cells (Journal article)

    Linford, A., Yoshimura, S. -I., Bastos, R. N., Langemeyer, L., Gerondopoulos, A., Rigden, D. J., & Barr, F. A. (2012). Rab14 and Its Exchange Factor FAM116 Link Endocytic Recycling and Adherens Junction Stability in Migrating Cells. DEVELOPMENTAL CELL, 22(5), 952-966. doi:10.1016/j.devcel.2012.04.010

    DOI: 10.1016/j.devcel.2012.04.010

    Rational Prediction of Antimicrobial Peptides Based on the Adaptive Neuro-Fuzzy Inference System (ANFIS) Application (Journal article)

    Fernandes, F. C., Rigden, D. J., & Franco, O. L. (2012). Rational Prediction of Antimicrobial Peptides Based on the Adaptive Neuro-Fuzzy Inference System (ANFIS) Application. Biopolymers, 98, 280-287.

    Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions (Journal article)

    Urbe, S., Liu, H., Hayes, S. D., Heride, C., Rigden, D. J., & Clague, M. J. (2012). Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions. MOLECULAR BIOLOGY OF THE CELL, 23(6), 1095-1103. doi:10.1091/mbc.E11-08-0668

    DOI: 10.1091/mbc.E11-08-0668

    Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions (Journal article)

    Urbe, S., Liu, H., Hayes, S. D., Heride, C., Rigden, D. J., & Clague, M. J. (2012). Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions. Molecular Biology of the Cell, 23(6), 1095-1103. doi:10.1091/mbc.E11-08-0668

    DOI: 10.1091/mbc.E11-08-0668

    Trypanosomes contain two highly different isoforms of peroxin PEX13 involved in glycosome biogenesis (Journal article)

    Brennand, A., Rigden, D. J., & Michels, P. A. M. (2012). Trypanosomes contain two highly different isoforms of peroxin PEX13 involved in glycosome biogenesis. FEBS LETTERS, 586(13), 1765-1771. doi:10.1016/j.febslet.2012.05.019

    DOI: 10.1016/j.febslet.2012.05.019

    mRNA 3 ' Tagging Is Induced by Nonsense-Mediated Decay and Promotes Ribosome Dissociation (Journal article)

    Morozov, I. Y., Jones, M. G., Gould, P. D., Crome, V., Wilson, J. B., Hall, A. J. W., . . . Caddick, M. X. (2012). mRNA 3 ' Tagging Is Induced by Nonsense-Mediated Decay and Promotes Ribosome Dissociation. MOLECULAR AND CELLULAR BIOLOGY, 32(13), 2585-2595. doi:10.1128/MCB.00316-12

    DOI: 10.1128/MCB.00316-12

    2011

    Ab Initio Modeling Led Annotation Suggests Nucleic Acid Binding Function for Many DUFs (Journal article)

    Rigden, D. J. (2011). Ab Initio Modeling Led Annotation Suggests Nucleic Acid Binding Function for Many DUFs. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 15(7-8), 431-438. doi:10.1089/omi.2010.0122

    DOI: 10.1089/omi.2010.0122

    Autophagy in parasitic protists: Unique features and drug targets (Journal article)

    Brennand, A., Gualdron-Lopez, M., Coppens, I., Rigden, D. J., Ginger, M. L., & Michels, P. A. M. (2011). Autophagy in parasitic protists: Unique features and drug targets. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 177(2), 83-99. doi:10.1016/j.molbiopara.2011.02.003

    DOI: 10.1016/j.molbiopara.2011.02.003

    Autophagy in protists (Journal article)

    Duszenko, M., Ginger, M. L., Brennand, A., Gualdron-Lopez, M., Colombo, M. -I., Coombs, G. H., . . . Michels, P. A. M. (2011). Autophagy in protists. AUTOPHAGY, 7(2), 127-158. doi:10.4161/auto.7.2.13310

    DOI: 10.4161/auto.7.2.13310

    Characterisation of a Desmosterol Reductase Involved in Phytosterol Dealkylation in the Silkworm, Bombyx mori (Journal article)

    Ciufo, L. F., Murray, P. A., Thompson, A., Rigden, D. J., & Rees, H. H. (2011). Characterisation of a Desmosterol Reductase Involved in Phytosterol Dealkylation in the Silkworm, Bombyx mori. PLOS ONE, 6(6). doi:10.1371/journal.pone.0021316

    DOI: 10.1371/journal.pone.0021316

    Characterisation of a Desmosterol Reductase Involved in Phytosterol Dealkylation in the Silkworm, Bombyx mori (Journal article)

    Ciufo, L. F., Murray, P. A., Thompson, A., Rigden, D. J., & Rees, H. H. (2011). Characterisation of a Desmosterol Reductase Involved in Phytosterol Dealkylation in the Silkworm, Bombyx mori. PLoS ONE, 6(6), e21316. doi:10.1371/journal.pone.0021316

    DOI: 10.1371/journal.pone.0021316

    Characterization of the relationship between integrase, excisionase and antirepressor activities associated with a superinfecting Shiga toxin encoding bacteriophage (Journal article)

    Fogg, P. C. M., Rigden, D. J., Saunders, J. R., McCarthy, A. J., & Allison, H. E. (2011). Characterization of the relationship between integrase, excisionase and antirepressor activities associated with a superinfecting Shiga toxin encoding bacteriophage. NUCLEIC ACIDS RESEARCH, 39(6), 2116-2129. doi:10.1093/nar/gkq923

    DOI: 10.1093/nar/gkq923

    Comparative Genomics of the Anopheline Glutathione S-Transferase Epsilon Cluster (Journal article)

    Ayres, C., Mueller, P., Dyer, N., Wilding, C., Rigden, D., & Donnelly, M. (2011). Comparative Genomics of the Anopheline Glutathione S-Transferase Epsilon Cluster. PLOS ONE, 6(12). doi:10.1371/journal.pone.0029237

    DOI: 10.1371/journal.pone.0029237

    Ferric iron uptake genes are differentially expressed in the presence of copper sulfides in Acidithiobacillus ferrooxidans strain LR (Journal article)

    Ferraz, L. F. C., Verde, L. C. L., Vicentini, R., Felicio, A. P., Ribeiro, M. L., Alexandrino, F., . . . Ottoboni, L. M. M. (2011). Ferric iron uptake genes are differentially expressed in the presence of copper sulfides in Acidithiobacillus ferrooxidans strain LR. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 99(3), 609-617. doi:10.1007/s10482-010-9533-2

    DOI: 10.1007/s10482-010-9533-2

    Identification and modelling of a PPM protein phosphatase fold in the Legionella pneumophila deAMPylase SidD (Journal article)

    Rigden, D. J. (2011). Identification and modelling of a PPM protein phosphatase fold in the Legionella pneumophila deAMPylase SidD. FEBS LETTERS, 585(17), 2749-2754. doi:10.1016/j.febslet.2011.08.006

    DOI: 10.1016/j.febslet.2011.08.006

    Improving Cry8Ka toxin activity towards the cotton boll weevil (Anthonomus grandis) (Journal article)

    Oliveira, G. R., Silva, M. C. M., Lucena, W. A., Nakasu, E. Y. T., Firmino, A. A. P., Beneventi, M. A., . . . Grossi-de-Sa, M. F. (2011). Improving Cry8Ka toxin activity towards the cotton boll weevil (Anthonomus grandis). BMC BIOTECHNOLOGY, 11. doi:10.1186/1472-6750-11-85

    DOI: 10.1186/1472-6750-11-85

    New Structural and Functional Contexts of the Dx[DN]xDG Linear Motif: Insights into Evolution of Calcium-Binding Proteins (Journal article)

    Rigden, D. J., Woodhead, D. D., Wong, P. W. H., & Galperin, M. Y. (2011). New Structural and Functional Contexts of the Dx[DN]xDG Linear Motif: Insights into Evolution of Calcium-Binding Proteins. PLOS ONE, 6(6). doi:10.1371/journal.pone.0021507

    DOI: 10.1371/journal.pone.0021507

    Structural variability of the ubiquitin specific protease DUSP-UBL double domains (Journal article)

    Elliott, P. R., Liu, H., Pastok, M. W., Grossmann, G. J., Rigden, D. J., Clague, M. J., . . . Barsukov, I. L. (2011). Structural variability of the ubiquitin specific protease DUSP-UBL double domains. FEBS LETTERS, 585(21), 3385-3390. doi:10.1016/j.febslet.2011.09.040

    DOI: 10.1016/j.febslet.2011.09.040

    2010

    CUCU Modification of mRNA Promotes Decapping and Transcript Degradation in Aspergillus nidulans (Journal article)

    Morozov, I. Y., Jones, M. G., Razak, A. A., Rigden, D. J., & Caddick, M. X. (2010). CUCU Modification of mRNA Promotes Decapping and Transcript Degradation in Aspergillus nidulans. MOLECULAR AND CELLULAR BIOLOGY, 30(2), 460-469. doi:10.1128/MCB.00997-09

    DOI: 10.1128/MCB.00997-09

    Distinct roles for Caf1, Ccr4, Edc3 and CutA in the co-ordination of transcript deadenylation, decapping and P-body formation in Aspergillus nidulans (Journal article)

    Morozov, I. Y., Jones, M. G., Spiller, D. G., Rigden, D. J., Dattenboeck, C., Novotny, R., . . . Caddick, M. X. (2010). Distinct roles for Caf1, Ccr4, Edc3 and CutA in the co-ordination of transcript deadenylation, decapping and P-body formation in Aspergillus nidulans. MOLECULAR MICROBIOLOGY, 76(2), 503-516. doi:10.1111/j.1365-2958.2010.07118.x

    DOI: 10.1111/j.1365-2958.2010.07118.x

    Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors (Journal article)

    Yoshimura, S. -I., Gerondopoulos, A., Linford, A., Rigden, D. J., & Barr, F. A. (2010). Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. JOURNAL OF CELL BIOLOGY, 191(2), 367-381. doi:10.1083/jcb.201008051

    DOI: 10.1083/jcb.201008051

    Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation (Journal article)

    Polson, H. E. J., de lartigue, J., Rigden, D. J., Reedijk, M., Urbe, S., Clague, M. J., & Tooze, S. A. (2010). Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. AUTOPHAGY, 6(4), 506-522. doi:10.4161/auto.6.4.11863

    DOI: 10.4161/auto.6.4.11863

    Mining metagenomic data for novel domains: BACON, a new carbohydrate-binding module (Journal article)

    Mello, L. V., Chen, X., & Rigden, D. J. (2010). Mining metagenomic data for novel domains: BACON, a new carbohydrate-binding module. FEBS LETTERS, 584(11), 2421-2426. doi:10.1016/j.febslet.2010.04.045

    DOI: 10.1016/j.febslet.2010.04.045

    2009

    Ab initio protein modelling reveals novel human MIT domains (Journal article)

    Rigden, D. J., Liu, H., Hayes, S. D., Urbe, S., & Clague, M. J. (2009). Ab initio protein modelling reveals novel human MIT domains. FEBS LETTERS, 583(5), 872-878. doi:10.1016/j.febslet.2009.02.012

    DOI: 10.1016/j.febslet.2009.02.012

    Autophagy in protists - Examples of secondary loss, lineage-specific innovations, and the conundrum of remodeling a single mitochondrion (Journal article)

    Rigden, D. J., Michels, P. A., & Ginger, M. L. (2009). Autophagy in protists - Examples of secondary loss, lineage-specific innovations, and the conundrum of remodeling a single mitochondrion. Autophagy, 5(6), 784-794.

    Autophagy in protists Examples of secondary loss, lineage-specific innovations, and the conundrum of remodeling a single mitochondrion (Journal article)

    Rigden, D. J., Michels, P. A., & Ginger, M. L. (2009). Autophagy in protists Examples of secondary loss, lineage-specific innovations, and the conundrum of remodeling a single mitochondrion. AUTOPHAGY, 5(6), 784-794. doi:10.4161/auto.8838

    DOI: 10.4161/auto.8838

    Cathepsin L Digestion of Nanobioconjugates upon Endocytosis (Journal article)

    See, V., Free, P., Cesbron, Y., Nativo, P., Shaheen, U., Rigden, D. J., . . . Levy, R. (2009). Cathepsin L Digestion of Nanobioconjugates upon Endocytosis. ACS NANO, 3(9), 2461-2468. doi:10.1021/nn9006994

    DOI: 10.1021/nn9006994

    Does distant homology with Evf reveal a lipid binding site in Bacillus thuringiensis cytolytic toxins? (Journal article)

    Rigden, D. J. (2009). Does distant homology with Evf reveal a lipid binding site in Bacillus thuringiensis cytolytic toxins?. FEBS LETTERS, 583(10), 1555-1560. doi:10.1016/j.febslet.2009.04.038

    DOI: 10.1016/j.febslet.2009.04.038

    From protein structure to function with bioinformatics (Book)

    Rigden, D. J. (2009). From protein structure to function with bioinformatics. doi:10.1007/978-1-4020-9058-5

    DOI: 10.1007/978-1-4020-9058-5

    Identification of novel aspartic proteases from Strongyloides ratti and characterisation of their evolutionary relationships, stage-specific expression and molecular structure (Journal article)

    Mello, L. V., O'Meara, H., Rigden, D. J., & Paterson, S. (2009). Identification of novel aspartic proteases from Strongyloides ratti and characterisation of their evolutionary relationships, stage-specific expression and molecular structure. BMC GENOMICS, 10. doi:10.1186/1471-2164-10-611

    DOI: 10.1186/1471-2164-10-611

    Identification, characterization and essentiality of the unusual peroxin 13 from Trypanosoma brucei (Journal article)

    Verplaetse, E., Rigden, D. J., & Michels, P. A. M. (2009). Identification, characterization and essentiality of the unusual peroxin 13 from Trypanosoma brucei. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1793(3), 516-527. doi:10.1016/j.bbamcr.2008.12.020

    DOI: 10.1016/j.bbamcr.2008.12.020

    Molecular Dynamics and Electrochemical Investigations of a pH-Responsive Peptide Monolayer (Journal article)

    Doneux, T., Bouffier, L., Mello, L. V., Rigden, D. J., Kejnovska, I., Fernig, D. G., . . . Nichols, R. J. (2009). Molecular Dynamics and Electrochemical Investigations of a pH-Responsive Peptide Monolayer. JOURNAL OF PHYSICAL CHEMISTRY C, 113(16), 6792-6799. doi:10.1021/jp810859k

    DOI: 10.1021/jp810859k

    2008

    Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1 (Journal article)

    Saw, J. H., Mountain, B. W., Feng, L., Omelchenko, M. V., Hou, S., Saito, J. A., . . . Alam, M. (2008). Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1. GENOME BIOLOGY, 9(11). doi:10.1186/gb-2008-9-11-r161

    DOI: 10.1186/gb-2008-9-11-r161

    Molecular replacement using ab initio polyalanine models generated with ROSETTA (Journal article)

    Rigden, D. J., Keegan, R. M., & Winn, M. D. (2008). Molecular replacement using ab initio polyalanine models generated with ROSETTA. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 64, 1288-1291. doi:10.1107/S0907444908033192

    DOI: 10.1107/S0907444908033192

    Order within a mosaic distribution of mitochondrial c-type cytochrome biogenesis systems? (Journal article)

    Allen, J. W. A., Jackson, A. P., Rigden, D. J., Willis, A. C., Ferguson, S. J., & Ginger, M. L. (2008). Order within a mosaic distribution of mitochondrial c-type cytochrome biogenesis systems?. FEBS JOURNAL, 275(10), 2385-2402. doi:10.1111/j.1742-4658.2008.06380.x

    DOI: 10.1111/j.1742-4658.2008.06380.x

    Sequence analysis of GerM and SpoVS, uncharacterized bacterial sporulation proteins with widespread phylogenetic distribution (Journal article)

    Rigden, D. J., & Galperin, M. Y. (2008). Sequence analysis of GerM and SpoVS, uncharacterized bacterial sporulation proteins with widespread phylogenetic distribution. BIOINFORMATICS, 24(16), 1793-1797. doi:10.1093/bioinformatics/btn314

    DOI: 10.1093/bioinformatics/btn314

    The histidine phosphatase superfamily: structure and function (Journal article)

    Rigden, D. J. (2008). The histidine phosphatase superfamily: structure and function. BIOCHEMICAL JOURNAL, 409, 333-348. doi:10.1042/BJ20071097

    DOI: 10.1042/BJ20071097

    2007

    Acyl carrier protein phosphodiesterase (AcpH) of Escherichia coli is a non-canonical member of the HD phosphatase/phosphodiesterase family (Journal article)

    Thomas, J., Rigden, D. J., & Cronan, J. E. (2007). Acyl carrier protein phosphodiesterase (AcpH) of Escherichia coli is a non-canonical member of the HD phosphatase/phosphodiesterase family. BIOCHEMISTRY, 46(1), 129-136. doi:10.1021/bi061789e

    DOI: 10.1021/bi061789e

    An unsuspected ecdysteroid/steroid phosphatase activity in the key T-cell regulator, Sts-1: Surprising relationship to insect ecdysteroid phosphate phosphatase (Journal article)

    Davies, L., Anderson, I. P., Turner, P. C., Shirras, A. D., Rees, H. H., & Rigden, D. J. (2007). An unsuspected ecdysteroid/steroid phosphatase activity in the key T-cell regulator, Sts-1: Surprising relationship to insect ecdysteroid phosphate phosphatase. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 67(3), 720-731. doi:10.1002/prot.21357

    DOI: 10.1002/prot.21357

    Genome-based identification and characterization of a putative mucin-binding protein from the surface of Streptococcus pneumoniae (Journal article)

    Bumbaca, D., Littlejohn, J. E., Nayakanti, H., Lucas, A. H., Rigden, D. J., Galperin, M. Y., & Jedrzejas, M. J. (2007). Genome-based identification and characterization of a putative mucin-binding protein from the surface of Streptococcus pneumoniae. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 66(3), 547-558. doi:10.1002/prot.21205

    DOI: 10.1002/prot.21205

    Jaburetox-2Ec: An insecticidal peptide derived from an isoform of urease from the plant Canaualia ensiformis (Journal article)

    Mulinari, F., Staniscuaski, F., Bertholdo-Vargas, L. R., Postal, M., Oliveira-Neto, O. B., Riden, D. J., . . . Carlini, C. R. (2007). Jaburetox-2Ec: An insecticidal peptide derived from an isoform of urease from the plant Canaualia ensiformis. PEPTIDES, 28(10), 2042-2050. doi:10.1016/j.peptides.2007.08.009

    DOI: 10.1016/j.peptides.2007.08.009

    Structural flexibility in Trypanosoma brucei enolase revealed by X-ray crystallography and molecular dynamics (Journal article)

    Navarro, M. V. D. A. S., Dias, S. M. G., Mello, L. V., Giotto, M. T. D. S., Gavalda, S., Blonski, C., . . . Rigden, D. J. (2007). Structural flexibility in Trypanosoma brucei enolase revealed by X-ray crystallography and molecular dynamics. FEBS JOURNAL, 274(19), 5077-5089. doi:10.1111/j.1742-4658.2007.06027.x

    DOI: 10.1111/j.1742-4658.2007.06027.x

    The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase (Journal article)

    Yu, Z., Genest, P. -A., ter Riet, B., Sweeney, K., DiPaolo, C., Kieft, R., . . . Borst, P. (2007). The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase. NUCLEIC ACIDS RESEARCH, 35(7), 2107-2115. doi:10.1093/nar/gkm049

    DOI: 10.1093/nar/gkm049

    2006

    Alternate structural conformations of Streptococcus pneumoniae hyaluronan lyase: Insights into enzyme flexibility and underlying molecular mechanism of action (Journal article)

    Rigden, D. J., Littlejohn, J. E., Joshi, H. V., de Groot, B. L., & Jedrzejas, M. J. (2006). Alternate structural conformations of Streptococcus pneumoniae hyaluronan lyase: Insights into enzyme flexibility and underlying molecular mechanism of action. JOURNAL OF MOLECULAR BIOLOGY, 358(4), 1165-1178. doi:10.1016/j.jmb.2006.02.066

    DOI: 10.1016/j.jmb.2006.02.066

    Autophagy and related processes in trypanosomatids - Insights from genomic and bioinformatic analyses (Journal article)

    Herman, M., Gillies, S., Michels, P. A., & Rigden, D. L. (2006). Autophagy and related processes in trypanosomatids - Insights from genomic and bioinformatic analyses. AUTOPHAGY, 2(2), 107-118. doi:10.4161/auto.2.2.2369

    DOI: 10.4161/auto.2.2.2369

    Design of new benzoxazole-2-thione-derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole (Journal article)

    Rigden, D. J., Botzki, A., Nukui, M., Mewbourne, R. B., Lamani, E., Braun, S., . . . Jedrzejas, M. J. (2006). Design of new benzoxazole-2-thione-derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole. GLYCOBIOLOGY, 16(8), 757-765. doi:10.1093/glycob/cwj116

    DOI: 10.1093/glycob/cwj116

    Evolutionary analysis of fructose 2,6-bisphosphate metabolism (Journal article)

    Michels, P. A. M., & Rigden, D. J. (2006). Evolutionary analysis of fructose 2,6-bisphosphate metabolism. IUBMB LIFE, 58(3), 133-141. doi:10.1080/15216540600688280

    DOI: 10.1080/15216540600688280

    Molecular Modeling and inhibitory activity of cowpea cystatin against bean bruchid pests (Journal article)

    Aguiar, J. M., Franco, O. L., Rigden, D. J., Bloch, C., Monteiro, A. C. S., Flores, V. M. Q., . . . Fernandes, K. V. S. (2006). Molecular Modeling and inhibitory activity of cowpea cystatin against bean bruchid pests. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 63(3), 662-670. doi:10.1002/prot.20901

    DOI: 10.1002/prot.20901

    Mutagenic definition of a papain-like catalytic triad, sufficiency of the N-terminal domain for single-site core catalytic enzyme acylation, and C-terminal domain for augmentative metal activation of a eukaryotic phytochelatin synthase (Journal article)

    Romanyuk, N. D., Rigden, D. J., Vatamaniuk, O. K., Lang, A., Cahoon, R. E., Jez, J. M., & Rea, P. A. (2006). Mutagenic definition of a papain-like catalytic triad, sufficiency of the N-terminal domain for single-site core catalytic enzyme acylation, and C-terminal domain for augmentative metal activation of a eukaryotic phytochelatin synthase. PLANT PHYSIOLOGY, 141(3), 858-869. doi:10.1104/pp.106.082131

    DOI: 10.1104/pp.106.082131

    Understanding the cell in terms of structure and function: insights from structural genomics (Journal article)

    Rigden, D. J. (2006). Understanding the cell in terms of structure and function: insights from structural genomics. CURRENT OPINION IN BIOTECHNOLOGY, 17(5), 457-464. doi:10.1016/j.copbio.2006.07.004

    DOI: 10.1016/j.copbio.2006.07.004

    2005

    6-Phosphofructo-2-kinase and fructose-2,6-bisphosphatase in trypanosomatidae - Molecular characterization, database searches, modelling studies and evolutionary analysis (Journal article)

    Chevalier, N., Bertrand, L., Rider, M. H., Opperdoes, F. R., Rigden, D. J., & Michels, P. A. M. (2005). 6-Phosphofructo-2-kinase and fructose-2,6-bisphosphatase in trypanosomatidae - Molecular characterization, database searches, modelling studies and evolutionary analysis. FEBS JOURNAL, 272(14), 3542-3560. doi:10.1111/j.1742-4658.2005.04774.x

    DOI: 10.1111/j.1742-4658.2005.04774.x

    An inactivated nuclease-like domain in RecC with novel function: implications for evolution (Journal article)

    Rigden, D. J. (2005). An inactivated nuclease-like domain in RecC with novel function: implications for evolution. BMC STRUCTURAL BIOLOGY, 5. doi:10.1186/1472-6807-5-9

    DOI: 10.1186/1472-6807-5-9

    Analysis of glycoside hydrolase family 98: Catalytic machinery, mechanism and a novel putative carbohydrate binding module (Journal article)

    Rigden, D. J. (2005). Analysis of glycoside hydrolase family 98: Catalytic machinery, mechanism and a novel putative carbohydrate binding module. FEBS LETTERS, 579(25), 5466-5472. doi:10.1016/j.febslet.2005.09.011

    DOI: 10.1016/j.febslet.2005.09.011

    Characterization and functional investigation of an Arabidopsis cDNA encoding a homologue to the d-PGMase superfamily (Journal article)

    Bourgis, F., Botha, F. C., Mani, S., Hiten, F. N., Rigden, D. J., & Verbruggen, N. (2005). Characterization and functional investigation of an Arabidopsis cDNA encoding a homologue to the d-PGMase superfamily. JOURNAL OF EXPERIMENTAL BOTANY, 56(414), 1129-1142. doi:10.1093/jxb/eri105

    DOI: 10.1093/jxb/eri105

    Implications of a genomic search for autophagy-related genes in trypanosomatids (Journal article)

    Rigden, D. J., Herman, M., Gillies, S., & Michels, P. A. M. (2005). Implications of a genomic search for autophagy-related genes in trypanosomatids. BIOCHEMICAL SOCIETY TRANSACTIONS, 33, 972-974. doi:10.1042/BST0330972

    DOI: 10.1042/BST0330972

    Implications of a genomic search for autophagy-related genes in trypanosomatids. (Journal article)

    Rigden, D. J., Herman, M., Gillies, S., & Michels, P. A. (2005). Implications of a genomic search for autophagy-related genes in trypanosomatids.. Biochemical Society transactions, 33(Pt 5), 972-974. doi:10.1042/bst20050972

    DOI: 10.1042/bst20050972

    Monomorphic subtelomeric DNA in the filamentous fungus, Metarhizium anisopliae,contains a RecQ helicase-like gene (Journal article)

    Inglis, P. W., Rigden, D. J., Mello, L. V., Louis, E. J., & Valadares-Inglis, M. C. (2005). Monomorphic subtelomeric DNA in the filamentous fungus, Metarhizium anisopliae,contains a RecQ helicase-like gene. MOLECULAR GENETICS AND GENOMICS, 274(1), 79-90. doi:10.1007/s00438-005-1154-5

    DOI: 10.1007/s00438-005-1154-5

    Nucleotide sequence and phylogenetic analyses of the DNA polymerase gene of Anticarsia gemmatalis nucleopolyhedrovirus (Journal article)

    Dalmolin, C. C., da Silva, F. R., Mello, L. V., Rigden, D. J., & Castro, M. E. B. (2005). Nucleotide sequence and phylogenetic analyses of the DNA polymerase gene of Anticarsia gemmatalis nucleopolyhedrovirus. VIRUS RESEARCH, 110(1-2), 99-109. doi:10.1016/j.virusres.2005.01.010

    DOI: 10.1016/j.virusres.2005.01.010

    OMICS-related research in Latin America (Journal article)

    Rigden, D. J., & Galperin, M. Y. (2005). OMICS-related research in Latin America. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 9(2), 129. doi:10.1089/omi.2005.9.129

    DOI: 10.1089/omi.2005.9.129

    OMICS-related research in South America (Journal article)

    Galperin, M. Y., & Rigden, D. J. (2005). OMICS-related research in South America. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 9(1), 1. doi:10.1089/omi.2005.9.1

    DOI: 10.1089/omi.2005.9.1

    Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration (Journal article)

    Takeuchi, H., Rigden, D. J., Ebrahimi, B., Turner, P. C., & Rees, H. H. (2005). Regulation of ecdysteroid signalling during Drosophila development: identification, characterization and modelling of ecdysone oxidase, an enzyme involved in control of ligand concentration. BIOCHEMICAL JOURNAL, 389, 637-645. doi:10.1042/BJ20050498

    DOI: 10.1042/BJ20050498

    2004

    A distant evolutionary relationship between GPI-specific phospholipase D and bacterial phosphatidylcholine-preferring phospholipase C (Journal article)

    Rigden, D. J. (2004). A distant evolutionary relationship between GPI-specific phospholipase D and bacterial phosphatidylcholine-preferring phospholipase C. FEBS LETTERS, 569(1-3), 229-234. doi:10.1016/j.febslet.2004.05.071

    DOI: 10.1016/j.febslet.2004.05.071

    A diverse family of serine protemase genes expressed in cotton boll weevil (Anthonomus grandis): implications for the design of pest-resistant transgenic cotton plants (Journal article)

    Oliveira-Neto, O. B., Batista, J. A. N., Rigden, D. J., Fragoso, R. R., Silva, R. O., Gomes, E. A., . . . Grossi-de-Sa, M. F. (2004). A diverse family of serine protemase genes expressed in cotton boll weevil (Anthonomus grandis): implications for the design of pest-resistant transgenic cotton plants. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 34(9), 903-918. doi:10.1016/j.ibmb.2004.06.001

    DOI: 10.1016/j.ibmb.2004.06.001

    A new type of antimicrobial protein with multiple histidines from the hard tick, Amblyomma hebraeum (Journal article)

    Lai, R., Takeuchi, H., Lomas, L. O., Jonczy, J., Rigden, D. J., Rees, H. H., & Turner, P. C. (2004). A new type of antimicrobial protein with multiple histidines from the hard tick, Amblyomma hebraeum. Faseb Journal, 18(10), 162-178.

    A new type of antimicrobial protein with multiple histidines from the hard tick, Amblyomma hebraeum (Journal article)

    Lai, R., Takeuchi, H., Lomas, L. O., Jonczy, J., Rigden, D. J., Rees, H. H., & Turner, P. C. (2004). A new type of antimicrobial protein with multiple histidines from the hard tick, Amblyomma hebraeum. FASEB JOURNAL, 18(10), 1447-+. doi:10.1096/fj.03-1154fje

    DOI: 10.1096/fj.03-1154fje

    Archaea recruited D-Tyr-tRNA(Tyr) deacylase for editing in Thr-tRNA synthetase (Journal article)

    Rigden, D. J. (2004). Archaea recruited D-Tyr-tRNA(Tyr) deacylase for editing in Thr-tRNA synthetase. RNA-A PUBLICATION OF THE RNA SOCIETY, 10(12), 1845-1851. doi:10.1261/rna.7115404

    DOI: 10.1261/rna.7115404

    Characterization of the ligandin site of maize glutathione S-transferase I (Journal article)

    Axarli, I. A., Rigden, D. J., & Labrou, N. E. (2004). Characterization of the ligandin site of maize glutathione S-transferase I. BIOCHEMICAL JOURNAL, 382, 885-893. doi:10.1042/BJ20040298

    DOI: 10.1042/BJ20040298

    Designed chimaeric galactosyl-mimodye ligands for the purification of Pseudomonas fluorescens beta-galactose dehydrogenase (Journal article)

    Mazitsos, C. F., Rigden, D. J., & Clonis, Y. D. (2004). Designed chimaeric galactosyl-mimodye ligands for the purification of Pseudomonas fluorescens beta-galactose dehydrogenase. JOURNAL OF CHROMATOGRAPHY A, 1029(1-2), 103-112. doi:10.1016/j.chroma.2003.09.048

    DOI: 10.1016/j.chroma.2003.09.048

    Engineering the pH-dependence of kinetic parameters of maize glutathione S-transferase I by site-directed mutagenesis (Journal article)

    Labrou, N. E., Rigden, D. J., & Clonis, Y. D. (2004). Engineering the pH-dependence of kinetic parameters of maize glutathione S-transferase I by site-directed mutagenesis. BIOMOLECULAR ENGINEERING, 21(2), 61-66. doi:10.1016/j.bioeng.2003.10.002

    DOI: 10.1016/j.bioeng.2003.10.002

    L-ascorbic acid 6-hexadecanoate, a potent hyaluronidase inhibitor - X-ray structure and molecular modeling of enzyme-inhibitor complexes (Journal article)

    Botzki, A., Rigden, D. J., Braun, S., Nukui, M., Salmen, S., Hoechstetter, J., . . . Buschauer, A. (2004). L-ascorbic acid 6-hexadecanoate, a potent hyaluronidase inhibitor - X-ray structure and molecular modeling of enzyme-inhibitor complexes. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(44), 45990-45997. doi:10.1074/jbc.M406146200

    DOI: 10.1074/jbc.M406146200

    Molecular cloning of a cysteine proteinase cDNA from the cotton boll weevil Anthonomus grandis (Coleoptera : Curculionidae) (Journal article)

    Neto, O. B. D., Batista, J. A. N., Rigden, D. J., Franco, O. L., Fragoso, R. R., Monteiro, A. C. S., . . . Grossi-De-Sa, M. F. (2004). Molecular cloning of a cysteine proteinase cDNA from the cotton boll weevil Anthonomus grandis (Coleoptera : Curculionidae). BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 68(6), 1235-1242. Retrieved from http://gateway.webofknowledge.com/

    Mutants of common bean alpha-amylase inhibitor-2 as an approach to investigate binding specificity to alpha-amylases (Journal article)

    da Silva, M. C. M., Mello, L. V., Coutinho, M. V., Rigden, D. J., Neshich, G., Chrispeels, M. J., & Grossi-De-Sa, M. F. (2004). Mutants of common bean alpha-amylase inhibitor-2 as an approach to investigate binding specificity to alpha-amylases. PESQUISA AGROPECUARIA BRASILEIRA, 39(3), 201-208. doi:10.1590/S0100-204X2004000300001

    DOI: 10.1590/S0100-204X2004000300001

    Sequence analysis and characterization of a novel fibronectin-binding repeat domain from the surface of Streptococcus pneumoniae (Journal article)

    Bumbaca, D., Littlejohn, J. E., Nayakanti, H., Rigden, D. J., Galperin, M. Y., & Jedrzejas, M. J. (2004). Sequence analysis and characterization of a novel fibronectin-binding repeat domain from the surface of Streptococcus pneumoniae. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 8(4), 341-356. doi:10.1089/omi.2004.8.341

    DOI: 10.1089/omi.2004.8.341

    The DxDxDG motif for calcium binding: Multiple structural contexts and implications for evolution (Journal article)

    Rigden, D. J., & Galperin, M. Y. (2004). The DxDxDG motif for calcium binding: Multiple structural contexts and implications for evolution. JOURNAL OF MOLECULAR BIOLOGY, 343(4), 971-984. doi:10.1016/j.jmb.2004.08.077

    DOI: 10.1016/j.jmb.2004.08.077

    The PA14 domain, a conserved all-beta domain in bacterial toxins, enzymes, adhesins and signaling molecules (Journal article)

    Rigden, D. J., Mello, L. V., & Galperin, M. Y. (2004). The PA14 domain, a conserved all-beta domain in bacterial toxins, enzymes, adhesins and signaling molecules. TRENDS IN BIOCHEMICAL SCIENCES, 29(7), 335-339. doi:10.1016/j.tibs.2004.05.002

    DOI: 10.1016/j.tibs.2004.05.002

    The structure-function relationship in the clostripain family of peptidases (Journal article)

    Labrou, N. E., & Rigden, D. J. (2004). The structure-function relationship in the clostripain family of peptidases. EUROPEAN JOURNAL OF BIOCHEMISTRY, 271(5), 983-992. doi:10.1111/j.1432-1033.2004.04000.x

    DOI: 10.1111/j.1432-1033.2004.04000.x

    Weeds, worms, and more. Papain's long-lost cousin, phytochelatin synthase (Journal article)

    Rea, P. A., Vatamaniuk, O. K., & Rigden, D. J. (2004). Weeds, worms, and more. Papain's long-lost cousin, phytochelatin synthase. PLANT PHYSIOLOGY, 136(1), 2463-2474. doi:10.1104/pp.104.048579

    DOI: 10.1104/pp.104.048579

    2003

    Amidase domains from bacterial and phage autolysins define a family of gamma-D,L-glutamate-specific amidohydrolases (Journal article)

    Rigden, D. J., Jedrzejas, M. J., & Galperin, M. Y. (2003). Amidase domains from bacterial and phage autolysins define a family of gamma-D,L-glutamate-specific amidohydrolases. TRENDS IN BIOCHEMICAL SCIENCES, 28(5), 230-234. doi:10.1016/S0968-0004(03)00062-8

    DOI: 10.1016/S0968-0004(03)00062-8

    An extracellular calcium-binding domain in bacteria with a distant relationship to EF-hands (Journal article)

    Rigden, D. J., Jedrzejas, M. J., & Galperin, M. Y. (2003). An extracellular calcium-binding domain in bacteria with a distant relationship to EF-hands. FEMS MICROBIOLOGY LETTERS, 221(1), 103-110. doi:10.1016/S0378-1097(03)00160-5

    DOI: 10.1016/S0378-1097(03)00160-5

    Analysis of structure and function of putative surface-exposed proteins encoded in the Streptococcus pneumoniae genome: A bioinformatics-based approach to vaccine and drug design (Journal article)

    Rigden, D. J., Galperin, M. Y., & Jedrzejas, M. J. (2003). Analysis of structure and function of putative surface-exposed proteins encoded in the Streptococcus pneumoniae genome: A bioinformatics-based approach to vaccine and drug design. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 38(2), 143-168. doi:10.1080/713609215

    DOI: 10.1080/713609215

    Fold recognition analysis of glycosyltransferase families: further members of structural superfamilies (Journal article)

    Franco, O. L., & Rigden, D. J. (2003). Fold recognition analysis of glycosyltransferase families: further members of structural superfamilies. GLYCOBIOLOGY, 13(10), 707-712. doi:10.1093/glycob/cwg098

    DOI: 10.1093/glycob/cwg098

    Genome-based identification of a carbohydrate binding module in Streptococcus pneumoniae hyaluronate lyase (Journal article)

    Rigden, D. J., & Jedrzejas, M. J. (2003). Genome-based identification of a carbohydrate binding module in Streptococcus pneumoniae hyaluronate lyase. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 52(2), 203-211. doi:10.1002/prot.10405

    DOI: 10.1002/prot.10405

    Identification and analysis of catalytic TIM barrel domains in seven further glycoside hydrolase families (Journal article)

    Rigden, D. J., Jedrzejas, M. J., & de Mello, L. V. (2003). Identification and analysis of catalytic TIM barrel domains in seven further glycoside hydrolase families. FEBS LETTERS, 544(1-3), 103-111. doi:10.1016/s0014-5793(03)00481-2

    DOI: 10.1016/s0014-5793(03)00481-2

    Identification of differentially expressed cDNA sequences in ovaries of sexual and apomictic plants of Brachiaria brizantha (Journal article)

    Rodrigues, J. C. M., Cabral, G. B., Dusi, D. M. A., de Mello, L. V., Rigden, D. J., & Carneiro, V. T. C. (2003). Identification of differentially expressed cDNA sequences in ovaries of sexual and apomictic plants of Brachiaria brizantha. PLANT MOLECULAR BIOLOGY, 53(6), 745-757. doi:10.1023/B:PLAN.0000023664.21910.bd

    DOI: 10.1023/B:PLAN.0000023664.21910.bd

    Insights into the catalytic mechanism of cofactor-independent phosphoglycerate mutase from X-ray crystallography, simulated dynamics and molecular modeling (Journal article)

    Rigden, D. J., Lamani, E., Mello, L. V., Littlejohn, J. E., & Jedrzejas, M. J. (2003). Insights into the catalytic mechanism of cofactor-independent phosphoglycerate mutase from X-ray crystallography, simulated dynamics and molecular modeling. JOURNAL OF MOLECULAR BIOLOGY, 328(4), 909-920. doi:10.1016/S0022-2836(03)00350-4

    DOI: 10.1016/S0022-2836(03)00350-4

    Kinetic characterization, structure modelling studies and crystallization of Trypanosoma brucei enolase (Journal article)

    Hannaert, V., Albert, M. A., Rigden, D. J., Giotto, M. T. D., Thiemann, O., Garratt, R. C., . . . Michels, P. A. M. (2003). Kinetic characterization, structure modelling studies and crystallization of Trypanosoma brucei enolase. EUROPEAN JOURNAL OF BIOCHEMISTRY, 270(15), 3205-3213. doi:10.1046/j.1432-1033.2003.03692.x

    DOI: 10.1046/j.1432-1033.2003.03692.x

    Molecular cloning of alpha-amylases from cotton boll weevil, Anthonomus grandis and structural relations to plant inhibitors: An approach to insect resistance (Journal article)

    Oliveira-Neto, O. B., Batista, J. A. N., Rigden, D. J., Franco, O. L., Falcao, R., Fragoso, R. R., . . . Grossi-de-Sa, M. F. (2003). Molecular cloning of alpha-amylases from cotton boll weevil, Anthonomus grandis and structural relations to plant inhibitors: An approach to insect resistance. JOURNAL OF PROTEIN CHEMISTRY, 22(1), 77-87. doi:10.1023/A:1023024012657

    DOI: 10.1023/A:1023024012657

    Plant-like traits associated with metabolism of Trypanosoma parasites (Journal article)

    Hannaert, V., Saavedra, E., Duffieux, F., Szikora, J. P., Rigden, D. J., Michels, P. A. M., & Opperdoes, F. R. (2003). Plant-like traits associated with metabolism of Trypanosoma parasites. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 100(3), 1067-1071. doi:10.1073/pnas.0335769100

    DOI: 10.1073/pnas.0335769100

    Structural diversity of calcium-binding proteins in bacteria: single-handed EF-hands? (Journal article)

    Rigden, D. J., Jedrzejas, M. J., Moroz, O. V., & Galperin, M. Y. (2003). Structural diversity of calcium-binding proteins in bacteria: single-handed EF-hands?. TRENDS IN MICROBIOLOGY, 11(7), 295-297. doi:10.1016/S0966-842X(03)00153-7

    DOI: 10.1016/S0966-842X(03)00153-7

    Structures of Streptococcus pneumoniae hyaluronate lyase in complex with chondroitin and chondroitin sulfate disaccharides - Insights into specificity and mechanism of action (Journal article)

    Rigden, D. J., & Jedrzejas, M. J. (2003). Structures of Streptococcus pneumoniae hyaluronate lyase in complex with chondroitin and chondroitin sulfate disaccharides - Insights into specificity and mechanism of action. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(50), 50596-50606. doi:10.1074/jbc.M307596200

    DOI: 10.1074/jbc.M307596200

    Structures of phosphate and trivanadate complexes of Bacillus stearothermophilus phosphatase PhoE: Structural and functional analysis in the cofactor-dependent phosphoglycerate mutase superfamily (Journal article)

    Rigden, D. J., Littlejohn, J. E., Henderson, K., & Jedrzejas, M. J. (2003). Structures of phosphate and trivanadate complexes of Bacillus stearothermophilus phosphatase PhoE: Structural and functional analysis in the cofactor-dependent phosphoglycerate mutase superfamily. JOURNAL OF MOLECULAR BIOLOGY, 325(3), 411-420. doi:10.1016/S0022-2836(02)01229-9

    DOI: 10.1016/S0022-2836(02)01229-9

    The crystal structure of Trypanosoma brucei enolase: Visualisation of the inhibitory metal binding site III and potential as target for selective, irreversible inhibition (Journal article)

    Giotto, M. T. D., Hannaert, V., Vertommen, D., Navarro, M. V. D. S., Rider, M. H., Michels, P. A. M., . . . Rigden, D. J. (2003). The crystal structure of Trypanosoma brucei enolase: Visualisation of the inhibitory metal binding site III and potential as target for selective, irreversible inhibition. JOURNAL OF MOLECULAR BIOLOGY, 331(3), 653-665. doi:10.1016/S0022-2836(03)00752-6

    DOI: 10.1016/S0022-2836(03)00752-6

    The structure of the D49 phospholipase A(2) piratoxin III from Bothrops pirajai reveals unprecedented structural displacement of the calcium-binding loop: possible relationship to cooperative substrate binding (Journal article)

    Rigden, D. J., Hwa, L. W., Marangoni, S., Toyama, M. H., & Polikarpov, I. (2003). The structure of the D49 phospholipase A(2) piratoxin III from Bothrops pirajai reveals unprecedented structural displacement of the calcium-binding loop: possible relationship to cooperative substrate binding. ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 59, 255-262. doi:10.1107/S0907444902021467

    DOI: 10.1107/S0907444902021467

    Unexpected catalytic site variation in phosphoprotein phosphatase homologues of cofactor-dependent phosphoglycerate mutase (Journal article)

    Rigden, D. J. (2003). Unexpected catalytic site variation in phosphoprotein phosphatase homologues of cofactor-dependent phosphoglycerate mutase. FEBS LETTERS, 536(1-3), 77-84. doi:10.1016/S0014-5793(03)00014-0

    DOI: 10.1016/S0014-5793(03)00014-0

    Use of phage display to select novel cystatins specific for Acanthoscelides obtectus cysteine proteinases (Journal article)

    Melo, F. R., Mello, M. O., Franco, O. L., Rigden, D. J., Mello, L. V., Genu, A. M., . . . Grossi-de-Sa, M. F. (2003). Use of phage display to select novel cystatins specific for Acanthoscelides obtectus cysteine proteinases. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1651(1-2), 146-152. doi:10.1016/S1570-9639(03)00264-4

    DOI: 10.1016/S1570-9639(03)00264-4

    2002

    Beta-helical catalytic domains in glycoside hydrolase families 49, 55 and 87: domain architecture, modelling and assignment of catalytic residues. (Journal article)

    Rigden, D. J., & Franco, O. L. (2002). Beta-helical catalytic domains in glycoside hydrolase families 49, 55 and 87: domain architecture, modelling and assignment of catalytic residues.. FEBS letters, 530(1-3), 225-232. doi:10.1016/s0014-5793(02)03490-7

    DOI: 10.1016/s0014-5793(02)03490-7

    Galactosyl-biomimetic dye-ligands for the purification of Dactylium dendroides galactose oxidase (Journal article)

    Mazitsos, C. F., Rigden, D. J., Tsoungas, P. G., & Clonis, Y. D. (2002). Galactosyl-biomimetic dye-ligands for the purification of Dactylium dendroides galactose oxidase. JOURNAL OF CHROMATOGRAPHY A, 954(1-2), 137-150. doi:10.1016/S0021-9673(02)00176-0

    DOI: 10.1016/S0021-9673(02)00176-0

    Galactosyl-mimodye ligands for Pseudomonas fluorescens beta-galactose dehydrogenase - Design, synthesis and evaluation (Journal article)

    Mazitsos, C. F., Rigden, D. J., Tsoungas, P. G., & Clonis, Y. D. (2002). Galactosyl-mimodye ligands for Pseudomonas fluorescens beta-galactose dehydrogenase - Design, synthesis and evaluation. EUROPEAN JOURNAL OF BIOCHEMISTRY, 269(22), 5391-5405. doi:10.1046/j.1432-1033.2002.03211.x

    DOI: 10.1046/j.1432-1033.2002.03211.x

    Inhibition of trypsin by cowpea thionin: Characterization, molecular modeling, and docking (Journal article)

    Melo, F. R., Rigden, D. J., Franco, O. L., Mello, L. V., Ary, M. B., de Sa, M. F. G., & Bloch, C. (2002). Inhibition of trypsin by cowpea thionin: Characterization, molecular modeling, and docking. PROTEINS-STRUCTURE FUNCTION AND GENETICS, 48(2), 311-319. doi:10.1002/prot.10142

    DOI: 10.1002/prot.10142

    Iterative database searches demonstrate that glycoside hydrolase families 27, 31, 36 and 66 share a common evolutionary origin with family 13 (Journal article)

    Rigden, D. J. (2002). Iterative database searches demonstrate that glycoside hydrolase families 27, 31, 36 and 66 share a common evolutionary origin with family 13. FEBS LETTERS, 523(1-3), 17-22. doi:10.1016/S0014-5793(02)02879-X

    DOI: 10.1016/S0014-5793(02)02879-X

    Leishmania donovani phosphofructokinase - Gene characterization, biochemical properties and structure-modelling studies (Journal article)

    Lopez, C., Chevalier, N., Hannaert, V., Rigden, D. J., Michels, P. A. M., & Ramirez, J. L. (2002). Leishmania donovani phosphofructokinase - Gene characterization, biochemical properties and structure-modelling studies. EUROPEAN JOURNAL OF BIOCHEMISTRY, 269(16), 3978-3989. doi:10.1046/j.1432-1033.2002.03086.x

    DOI: 10.1046/j.1432-1033.2002.03086.x

    Overlapping binding sites for trypsin and papain on a Kunitz-type proteinase inhibitor from Prosopis juliflora (Journal article)

    Franco, O. L., de Sa, M. F. G., Sales, M. P., Mello, L. V., Oliveira, A. S., & Rigden, D. J. (2002). Overlapping binding sites for trypsin and papain on a Kunitz-type proteinase inhibitor from Prosopis juliflora. PROTEINS-STRUCTURE FUNCTION AND GENETICS, 49(3), 335-341. doi:10.1002/prot.10228

    DOI: 10.1002/prot.10228

    Plant alpha-amylase inhibitors and their interaction with insect alpha-amylases - Structure, function and potential for crop protection (Journal article)

    Franco, O. L., Rigden, D. J., Melo, F. R., & Grossi-de-Sa, M. F. (2002). Plant alpha-amylase inhibitors and their interaction with insect alpha-amylases - Structure, function and potential for crop protection. EUROPEAN JOURNAL OF BIOCHEMISTRY, 269(2), 397-412. doi:10.1046/j.0014-2956.2001.02656.x

    DOI: 10.1046/j.0014-2956.2001.02656.x

    Plant α-amylase inhibitors and their interaction with insect α-amylases (Journal article)

    Franco, O. L., Rigden, D. J., Melo, F. R., & Grossi-de-Sá, M. F. (2002). Plant α-amylase inhibitors and their interaction with insect α-amylases. European Journal of Biochemistry, 269(2), 397-412. doi:10.1046/j.0014-2956.2001.02656.x

    DOI: 10.1046/j.0014-2956.2001.02656.x

    PrfA protein of Bacillus species: Prediction and demonstration of endonuclease activity on DNA (Journal article)

    Rigden, D. J., Setlow, P., Setlow, B., Bagyan, I., Stein, R. A., & Jedrzejas, M. J. (2002). PrfA protein of Bacillus species: Prediction and demonstration of endonuclease activity on DNA. PROTEIN SCIENCE, 11(10), 2370-2381. doi:10.1110/ps.0216802

    DOI: 10.1110/ps.0216802

    Putative pathogenesis-related genes within Solanum nigrum L. var. americanum genome: isolation of two genes coding for PR5-like proteins, phylogenetic and sequence analysis (Journal article)

    Campos, M. A., Ribeiro, S. G., Rigden, D. J., Monte, D. C., & De Sa, M. F. G. (2002). Putative pathogenesis-related genes within Solanum nigrum L. var. americanum genome: isolation of two genes coding for PR5-like proteins, phylogenetic and sequence analysis. PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY, 61(4), 205-216. doi:10.1006/pmpp.2002.0430

    DOI: 10.1006/pmpp.2002.0430

    Sequence conservation in the chagasin family suggests a common trend in cysteine proteinase binding by unrelated protein inhibitors (Journal article)

    Rigden, D. J., Mosolov, V. V., & Galperin, M. Y. (2002). Sequence conservation in the chagasin family suggests a common trend in cysteine proteinase binding by unrelated protein inhibitors. PROTEIN SCIENCE, 11(8), 1971-1977. doi:10.1110/ps.0207202

    DOI: 10.1110/ps.0207202

    Structure and mechanism of action of a cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus with broad specificity phosphatase activity (Journal article)

    Rigden, D. J., Mello, L. V., Setlow, P., & Jedrzejas, M. J. (2002). Structure and mechanism of action of a cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus with broad specificity phosphatase activity. JOURNAL OF MOLECULAR BIOLOGY, 315(5), 1129-1143. doi:10.1006/jmbi.2001.5290

    DOI: 10.1006/jmbi.2001.5290

    The putative effector-binding site of Leishmania mexicana pyruvate kinase studied by site-directed mutagenesis (Journal article)

    Hannaert, V., Yernaux, C., Rigden, D. J., Fothergill-Gilmore, L. A., Opperdoes, F. R., & Michels, P. A. M. (2002). The putative effector-binding site of Leishmania mexicana pyruvate kinase studied by site-directed mutagenesis. FEBS LETTERS, 514(2-3), 255-259. doi:10.1016/S0014-5793(02)02374-8

    DOI: 10.1016/S0014-5793(02)02374-8

    Use of covariance analysis for the prediction of structural domain boundaries from multiple protein sequence alignments (Journal article)

    Rigden, D. J. (2002). Use of covariance analysis for the prediction of structural domain boundaries from multiple protein sequence alignments. PROTEIN ENGINEERING, 15(2), 65-77. doi:10.1093/protein/15.2.65

    DOI: 10.1093/protein/15.2.65

    beta-Helical catalytic domains in glycoside hydrolase families 49, 55 and 87: domain architecture, modelling and assignment of catalytic residues (Journal article)

    Rigden, D. J., & Franco, O. L. (2002). beta-Helical catalytic domains in glycoside hydrolase families 49, 55 and 87: domain architecture, modelling and assignment of catalytic residues. FEBS LETTERS, 530(1-3), 225-232. doi:10.1016/S0014-5793(02)03490-7

    DOI: 10.1016/S0014-5793(02)03490-7

    2001

    A cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus is actually a broad specificity phosphatase (Journal article)

    Rigden, D. J., Bagyan, I., Lamani, E., Setlow, P., & Jedrzejas, M. J. (2001). A cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus is actually a broad specificity phosphatase. PROTEIN SCIENCE, 10(9), 1835-1846. doi:10.1110/ps.15701

    DOI: 10.1110/ps.15701

    A cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus is actually a broad specificity phosphatase (Journal article)

    Rigden, D. J., Bagyan, I., Lamani, E., Setlow, P., & Jedrzejas, M. J. (2001). A cofactor-dependent phosphoglycerate mutase homolog from Bacillus stearothermophilus is actually a broad specificity phosphatase. Protein Science, 10(9), 1835-1846. doi:10.1110/ps.15701

    DOI: 10.1110/ps.15701

    A novel heterodimeric antimicrobial peptide from the tree-frog Phyllomedusa distincta (Journal article)

    Batista, C. V. F., Scaloni, A., Rigden, D. J., Silva, L. R., Romero, A. R., Dukor, R., . . . Bloch, C. (2001). A novel heterodimeric antimicrobial peptide from the tree-frog Phyllomedusa distincta. FEBS LETTERS, 494(1-2), 85-89. doi:10.1016/S0014-5793(01)02324-9

    DOI: 10.1016/S0014-5793(01)02324-9

    Active-site characterization of Candida boidinii formate dehydrogenase (Journal article)

    LABROU, N. E., & RIGDEN, D. J. (2001). Active-site characterization of Candida boidinii formate dehydrogenase. Biochemical Journal, 354(2), 455-463. doi:10.1042/bj3540455

    DOI: 10.1042/bj3540455

    Active-site characterization of Candida boidinii formate dehydrogenase (Journal article)

    Labrou, N. E., & Rigden, D. J. (2001). Active-site characterization of Candida boidinii formate dehydrogenase. BIOCHEMICAL JOURNAL, 354, 455-463. doi:10.1042/0264-6021:3540455

    DOI: 10.1042/0264-6021:3540455

    Corrigendum to: The protease inhibitor chagasin of Trypanosoma cruzi adopts an immunoglobulin-type fold and may have arisen by horizontal gene transfer (FEBS 25160) (Journal article)

    Rigden, D. J., Monteiro, A. C., & Grossi de Sá, M. (2001). Corrigendum to: The protease inhibitor chagasin of Trypanosoma cruzi adopts an immunoglobulin-type fold and may have arisen by horizontal gene transfer (FEBS 25160). FEBS Letters, 506(3), 296. doi:10.1016/S0014-5793(01)02933-7

    DOI: 10.1016/S0014-5793(01)02933-7

    New family of glutathionyl-biomimetic ligands for affinity chromatography of glutathione-recognising enzymes (Journal article)

    Melissis, S. C., Rigden, D. J., & Clonis, Y. D. (2001). New family of glutathionyl-biomimetic ligands for affinity chromatography of glutathione-recognising enzymes. JOURNAL OF CHROMATOGRAPHY A, 917(1-2), 29-42. doi:10.1016/S0021-9673(01)00655-0

    DOI: 10.1016/S0021-9673(01)00655-0

    The protease inhibitor chagasin of Trypanosoma cruzi adopts an immunoglobulin-type fold and may have arisen by horizontal gene transfer (Journal article)

    Rigden, D. J., Monteiro, A. C. S., & de Sa, M. F. G. (2001). The protease inhibitor chagasin of Trypanosoma cruzi adopts an immunoglobulin-type fold and may have arisen by horizontal gene transfer. FEBS LETTERS, 504(1-2), 41-44. doi:10.1016/S0014-5793(01)02753-3

    DOI: 10.1016/S0014-5793(01)02753-3

    The protease inhibitor chagasin of Trypanosoma cruzi adopts an immunoglobulin-type fold and may have arisen by horizontal gene transfer (FEBS 25160) (vol 504, pg 41, 2001) (Journal article)

    Rigden, D. J., Monteiro, A. C. S., & de Sa, M. F. G. (2001). The protease inhibitor chagasin of Trypanosoma cruzi adopts an immunoglobulin-type fold and may have arisen by horizontal gene transfer (FEBS 25160) (vol 504, pg 41, 2001). FEBS LETTERS, 506(3), 296. doi:10.1016/S0014-5793(01)02933-7

    DOI: 10.1016/S0014-5793(01)02933-7

    2000

    Activity of wheat alpha-amylase inhibitors towards bruchid alpha-amylases and structural explanation of observed specificities (Journal article)

    Franco, O. L., Rigden, D. J., Melo, F. R., Bloch, C., Silva, C. P., & de Sa, M. F. G. (2000). Activity of wheat alpha-amylase inhibitors towards bruchid alpha-amylases and structural explanation of observed specificities. EUROPEAN JOURNAL OF BIOCHEMISTRY, 267(8), 2166-2173. doi:10.1046/j.1432-1327.2000.01199.x

    DOI: 10.1046/j.1432-1327.2000.01199.x

    Characterization of active-site mutants of Schizosaccharomyces pombe phosphoglycerate mutase (Journal article)

    Nairn, J., Duncan, D., Price, N. E., Kelly, S. M., Fothergill-Gilmore, L. A., Uhrinova, S., . . . Price, N. C. (2000). Characterization of active-site mutants of Schizosaccharomyces pombe phosphoglycerate mutase. European Journal of Biochemistry, 267(24), 7065-7074. doi:10.1046/j.1432-1327.2000.01802.x

    DOI: 10.1046/j.1432-1327.2000.01802.x

    Characterization of active-site mutants of Schizosaccharomyces pombe phosphoglycerate mutase - Elucidation of the roles of amino acids involved in substrate binding and catalysis (Journal article)

    Nairn, J., Duncan, D., Price, N. E., Kelly, S. M., Fothergill-Gilmore, L. A., Uhrinova, S., . . . Price, N. C. (2000). Characterization of active-site mutants of Schizosaccharomyces pombe phosphoglycerate mutase - Elucidation of the roles of amino acids involved in substrate binding and catalysis. EUROPEAN JOURNAL OF BIOCHEMISTRY, 267(24), 7065-7074. doi:10.1046/j.1432-1327.2000.01802.x

    DOI: 10.1046/j.1432-1327.2000.01802.x

    Characterization of the NAD(+) binding site of Candida boidinii formate dehydrogenase by affinity labelling and site-directed mutagenesis (Journal article)

    Labrou, N. E., Rigden, D. J., & Clonis, Y. D. (2000). Characterization of the NAD(+) binding site of Candida boidinii formate dehydrogenase by affinity labelling and site-directed mutagenesis. EUROPEAN JOURNAL OF BIOCHEMISTRY, 267(22), 6657-6664. doi:10.1046/j.1432-1327.2000.01761.x

    DOI: 10.1046/j.1432-1327.2000.01761.x

    Design and synthesis of germline-based hemi-humanized single-chain Fv against the CD18 surface antigen (Journal article)

    Caldas, C., Coelho, V. P. C. V., Rigden, D. J., Neschich, G., Moro, A. M., & Brigido, M. M. (2000). Design and synthesis of germline-based hemi-humanized single-chain Fv against the CD18 surface antigen. PROTEIN ENGINEERING, 13(5), 353-360. doi:10.1093/protein/13.5.353

    DOI: 10.1093/protein/13.5.353

    Glycerol kinase of Trypanosoma brucei (Journal article)

    Králová, I., Rigden, D. J., Opperdoes, F. R., & Michels, P. A. M. (2000). Glycerol kinase of Trypanosoma brucei. European Journal of Biochemistry, 267(8), 2323-2333. doi:10.1046/j.1432-1327.2000.01238.x

    DOI: 10.1046/j.1432-1327.2000.01238.x

    Glycerol kinase of Trypanosoma brucei - Cloning, molecular characterization and mutagenesis (Journal article)

    Kralova, I., Rigden, D. J., Opperdoes, F. R., & Michels, P. A. M. (2000). Glycerol kinase of Trypanosoma brucei - Cloning, molecular characterization and mutagenesis. EUROPEAN JOURNAL OF BIOCHEMISTRY, 267(8), 2323-2333. doi:10.1046/j.1432-1327.2000.01238.x

    DOI: 10.1046/j.1432-1327.2000.01238.x

    Leishmania pyruvate kinase: the crystal structure reveals the structural basis of its unique regulatory properties (Journal article)

    Fothergill-Gilmore, L. A., Rigden, D. J., Michels, P. A. M., & Phillips, S. E. V. (2000). Leishmania pyruvate kinase: the crystal structure reveals the structural basis of its unique regulatory properties. BIOCHEMICAL SOCIETY TRANSACTIONS, 28, 186-190. doi:10.1042/bst0280186

    DOI: 10.1042/bst0280186

    Purification, biochemical characterisation and partial primary structure of a new alpha-amylase inhibitor from Secale cereale (rye) (Journal article)

    Iulek, J., Franco, O. L., Silva, M., Slivinski, C. T., Bloch, C., Rigden, D. J., & de Sa, M. F. G. (2000). Purification, biochemical characterisation and partial primary structure of a new alpha-amylase inhibitor from Secale cereale (rye). INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 32(11-12), 1195-1204. doi:10.1016/S1357-2725(00)00053-4

    DOI: 10.1016/S1357-2725(00)00053-4

    Structural modeling of a plant disease resistance gene product domain (Journal article)

    Rigden, D. J., Mello, L. V., & Bertioli, D. J. (2000). Structural modeling of a plant disease resistance gene product domain. PROTEINS-STRUCTURE FUNCTION AND GENETICS, 41(1), 133-143. doi:3.0.CO;2-M">10.1002/1097-0134(20001001)41:1<133::AID-PROT150>3.0.CO;2-M

    DOI: 10.1002/1097-0134(20001001)41:1<133::AID-PROT150>3.0.CO;2-M

    Structural modeling of a plant disease resistance gene product domain (Journal article)

    Rigden, D. J., Mello, L. V., & Bertioli, D. J. (2000). Structural modeling of a plant disease resistance gene product domain. Proteins, 41(1), 133-143.

    Trypanosoma brucei contains a 2,3-bisphosphoglycerate independent phosphoglycerate mutase (Journal article)

    Chevalier, N., Rigden, D. J., Van Roy, J., Opperdoes, F. R., & Michels, P. A. M. (2000). Trypanosoma brucei contains a 2,3-bisphosphoglycerate independent phosphoglycerate mutase. EUROPEAN JOURNAL OF BIOCHEMISTRY, 267(5), 1464-1472. doi:10.1046/j.1432-1327.2000.01145.x

    DOI: 10.1046/j.1432-1327.2000.01145.x

    1999

    A structural model for the rolA protein and its interaction with DNA (Journal article)

    Rigden, D. J., & Carneiro, M. (1999). A structural model for the rolA protein and its interaction with DNA. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 37(4), 697-708. doi:3.0.CO;2-Y">10.1002/(SICI)1097-0134(19991201)37:4<697::AID-PROT18>3.0.CO;2-Y

    DOI: 10.1002/(SICI)1097-0134(19991201)37:4<697::AID-PROT18>3.0.CO;2-Y

    Manifesting heterozygotes in a Japanese family with a novel mutation in the muscle-specific phosphoglycerate mutase (PGAM-M) gene (Journal article)

    Hadjigeorgiou, G. M., Kawashima, N., Bruno, C., Andreu, A. L., Sue, C. M., Rigden, D. J., . . . DiMauro, S. (1999). Manifesting heterozygotes in a Japanese family with a novel mutation in the muscle-specific phosphoglycerate mutase (PGAM-M) gene. NEUROMUSCULAR DISORDERS, 9(6-7), 399-402. doi:10.1016/S0960-8966(99)00039-5

    DOI: 10.1016/S0960-8966(99)00039-5

    Polyanionic inhibitors of phosphoglycerate mutase: Combined structural and biochemical analysis (Journal article)

    Rigden, D. J., Walter, R. A., Phillips, S. E. V., & Fothergill-Gilmore, L. A. (1999). Polyanionic inhibitors of phosphoglycerate mutase: Combined structural and biochemical analysis. JOURNAL OF MOLECULAR BIOLOGY, 289(4), 691-699. doi:10.1006/jmbi.1999.2848

    DOI: 10.1006/jmbi.1999.2848

    Structure-activity studies on cysteine-substituted neurokinin A analogs (Journal article)

    Labrou, N. E., Mello, L. V., Rigden, D. J., Keen, J. N., & Findlay, J. B. C. (1999). Structure-activity studies on cysteine-substituted neurokinin A analogs. PEPTIDES, 20(7), 795-801. doi:10.1016/S0196-9781(99)00064-9

    DOI: 10.1016/S0196-9781(99)00064-9

    Structure-activity studies on cysteine-substituted neurokinin A analogs (Journal article)

    Labrou, N. E., Mello, L. V., Rigden, D. J., Keen, J. N., & Findlay, J. B. (1999). Structure-activity studies on cysteine-substituted neurokinin A analogs. Peptides, 20(7), 795-801.

    Sulphate ions observed in the 2.12 angstrom structure of a new crystal form of S-cerevisiae phosphoglycerate mutase provide insights into understanding the catalytic mechanism (Journal article)

    Rigden, D. J., Walter, R. A., Phillips, S. E. V., & Fothergill-Gilmore, L. A. (1999). Sulphate ions observed in the 2.12 angstrom structure of a new crystal form of S-cerevisiae phosphoglycerate mutase provide insights into understanding the catalytic mechanism. JOURNAL OF MOLECULAR BIOLOGY, 286(5), 1507-1517. doi:10.1006/jmbi.1999.2566

    DOI: 10.1006/jmbi.1999.2566

    The role of the C-terminal region in phosphoglycerate mutase (Journal article)

    WALTER, R. A., NAIRN, J., DUNCAN, D., PRICE, N. C., KELLY, S. M., RIGDEN, D. J., & FOTHERGILL-GILMORE, L. A. (1999). The role of the C-terminal region in phosphoglycerate mutase. Biochemical Journal, 337(1), 89-95. doi:10.1042/bj3370089

    DOI: 10.1042/bj3370089

    The role of the C-terminal region in phosphoglycerate mutase (Journal article)

    Walter, R. A., Nairn, J., Duncan, D., Price, N. C., Kelly, S. M., Rigden, D. J., & Fothergill-Gilmore, L. A. (1999). The role of the C-terminal region in phosphoglycerate mutase. BIOCHEMICAL JOURNAL, 337, 89-95. doi:10.1042/0264-6021:3370089

    DOI: 10.1042/0264-6021:3370089

    The structure of pyruvate kinase from Leishmania mexicana reveals details of the allosteric transition and unusual effector specificity (Journal article)

    Rigden, D. J., Phillips, S. E. V., Michels, P. A. M., & Fothergill-Gilmore, L. A. (1999). The structure of pyruvate kinase from Leishmania mexicana reveals details of the allosteric transition and unusual effector specificity. JOURNAL OF MOLECULAR BIOLOGY, 291(3), 615-635. doi:10.1006/jmbi.1999.2918

    DOI: 10.1006/jmbi.1999.2918

    The structure of pyruvate kinase from Leishmania mexicana reveals details of the allosteric transition and unusual effector specificity (vol 291, pg 615, 1999) (Journal article)

    Rigden, D. J., Phillips, S. E. V., Michels, P. A. M., & Fothergill-Gilmore, L. A. (1999). The structure of pyruvate kinase from Leishmania mexicana reveals details of the allosteric transition and unusual effector specificity (vol 291, pg 615, 1999). JOURNAL OF MOLECULAR BIOLOGY, 293(3), 745-749. doi:10.1006/jmbi.1999.3170

    DOI: 10.1006/jmbi.1999.3170

    1998

    The 2.3 angstrom X-ray crystal structure of S-cerevisiae phosphoglycerate mutase (Journal article)

    Rigden, D. J., Alexeev, D., Phillips, S. E. V., & Fothergill-Gilmore, L. A. (1998). The 2.3 angstrom X-ray crystal structure of S-cerevisiae phosphoglycerate mutase. JOURNAL OF MOLECULAR BIOLOGY, 276(2), 449-459. doi:10.1006/jmbi.1997.1554

    DOI: 10.1006/jmbi.1997.1554

    1997

    The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei must have evolved from an ancestral pyrophosphate-dependent enzyme (Journal article)

    Michels, P. A. M., Chevalier, N., Opperdoes, F. R., Rider, M. H., & Rigden, D. J. (1997). The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei must have evolved from an ancestral pyrophosphate-dependent enzyme. EUROPEAN JOURNAL OF BIOCHEMISTRY, 250(3), 698-704. doi:10.1111/j.1432-1033.1997.00698.x

    DOI: 10.1111/j.1432-1033.1997.00698.x

    1996

    Cloning and sequencing of a gene encoding pyruvate kinase from Schizosaccharomyces pombe: implications for quaternary structure and regulation of the enzyme (Journal article)

    NAIRN, J., SMITH, S., ALLISON, P., RIGDEN, D., FOTHERGILLGILMORE, L., & PRICE, N. (1996). Cloning and sequencing of a gene encoding pyruvate kinase from Schizosaccharomyces pombe: implications for quaternary structure and regulation of the enzyme. FEMS Microbiology Letters, 136(3), 329. doi:10.1016/0378-1097(96)00035-3

    DOI: 10.1016/0378-1097(96)00035-3

    Phosphoglycerate mutase from Schizosaccharomyces pombe: Development of an expression system and characterisation of three histidine mutants of the enzyme (Journal article)

    Nairn, J., Price, N. C., Kelly, S. M., Rigden, D., FothergillGilmore, L. A., & Krell, T. (1996). Phosphoglycerate mutase from Schizosaccharomyces pombe: Development of an expression system and characterisation of three histidine mutants of the enzyme. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 1296(1), 69-75. doi:10.1016/0167-4838(96)00046-5

    DOI: 10.1016/0167-4838(96)00046-5

    1995

    CLONING AND SEQUENCING OF A GENE ENCODING PYRUVATE-KINASE FROM SCHIZOSACCHAROMYCES-POMBE - IMPLICATIONS FOR QUATERNARY STRUCTURE AND REGULATION OF THE ENZYME (Journal article)

    NAIRN, J., SMITH, S., ALLISON, P. J., RIGDEN, D., FOTHERGILLGILMORE, L. A., & PRICE, N. C. (1995). CLONING AND SEQUENCING OF A GENE ENCODING PYRUVATE-KINASE FROM SCHIZOSACCHAROMYCES-POMBE - IMPLICATIONS FOR QUATERNARY STRUCTURE AND REGULATION OF THE ENZYME. FEMS MICROBIOLOGY LETTERS, 134(2-3), 221-226. doi:10.1016/0378-1097(95)00408-3

    DOI: 10.1016/0378-1097(95)00408-3

    1990

    Human adipose tissue glycogen levels and responses to carbohydrate feeding (Journal article)

    Rigden, D. J., Jellyman, A. E., Frayn, K. N., & Coppack, S. W. (1990). Human adipose tissue glycogen levels and responses to carbohydrate feeding. Eur J Clin Nutr, 44(9), 689-692.
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