Photo of Dr Dan Rigden

Dr Dan Rigden BA, PhD

Reader in Post-Genomic Bioinformatics Biochemistry

    Biography

    Personal Statement

    I am a Reader in post-genomic bioinformatics in the Institute of Integrative Biology. My interests span the broad relationships between protein sequences, structures and functions and how these evolve with time. As such, I apply a wide range of bioinformatics tools to diverse proteins of interest. This leads to interesting collaborations across the Institute and more broadly. A current prime interest is solution of crystal structures by Molecular Replacement using unconventional protein models. This has been implemented in our program AMPLE (ample.readthedocs.io), available as part of the CCP4 suite (www.ccp4.ac.uk).

    Personal Distinctions

    • AMPLE: unconventional Molecular Replacement (Invitation to Speak, CCP4 Study Weekend 2017)
    • Exploiting structural bioinformatics for unconventional Molecular Replacement (Invitation to Speak, 12th International Conference on Biology and Synchrotron Radiation, SLAC, Stanford 2016)
    • Applications of contact predictions to structural biology (Invitation to Speak, British Biophysical Society 2016 Biennial Meeting 2016)
    • AMPLE, a pipeline for unconventional Molecular Replacement (Invitation to Speak, CCP4/APS School in Macromolecular Crystallography 2016)
    • Bioinformatics for MR (and beyond) (Invitation to Speak, CCP4/APS School in Macromolecular Crystallography 2016)
    • AMPLE, a pipeline for unconventional Molecular Replacement (Invitation to Speak, IFSC/CCP4 Macromolecular Crystallography School 2016 2016)
    • Bioinformatics for Crystallographers (Invitation to Perform, IFSC/CCP4 Macromolecular Crystallography School 2016 2016)
    • AMPLE: exploiting structural bioinformatics developments to extend the reach of molecular replacement to difficult cases (Invitation to Speak, European Crystallographic Meeting (ECM29) 2015)
    • AMPLE, a program for unconventional Molecular Replacement (Invitation to Speak, Dundee Bioinformatics Symposium Organisers 2014)
    • AMPLE, a program to process ab initio structure predictions into search models for MR (Invitation to Speak, CCP4 Study Weekend 2013 organising committee 2013)
    • A cluster and truncate approach to processing ab initio models for Molecular Replacement. (Invitation to Speak, European Crystallographic Meeting (ECM27) 2012)
    • Bioinformatics to explore the connections between protein sequence, structure and evolution (Invitation to Speak, University of Campinas 2012)
    • Structure Solution by Molecular Replacement using ab initio protein models (Invitation to Speak, IUCr 2011 Organising Committee 2011)
    • Searching for PEX13 in trypanosomatids: three surprises (Invitation to Speak, 43rd Microsymposium on glycosomes, trypanosomatid metabolism and drug discovery' 2011 2011)
    • Taking the initiative with ab initio protein modelling (Invitation to Speak, Dundee Bioinformatics Symposium Organisers 2011)
    • Ab initio modelling: from Holy Grail to everyday protein bioinformatics tool (Invitation to Speak, Wellcome Sanger Centre 2010)
    • Ab initio modelling: from Holy Grail to everyday protein bioinformatics tool (Invitation to Speak, STFC Seminar Organisers 2009)
    • Ab initio modelling: from Holy Grail to everyday protein bioinformatics tool (Invitation to Speak, ISBM/ECCB 2009 Organising Committee 2009)
    • Distribution and evolution of autophagy proteins in unicellular eukaryotes (Invitation to Speak, organisers 2008)
    • Fructose-1,6-bisphosphatase, a surprising yet promising drug target in Leishmania (Invitation to Speak, 39th Microsymposium on glycosomes, trypanosomatid metabolism and drug discovery' 2007)
    • Autophagy and related processes in trypanosomatids:insights from genomic and bioinformatics analyses (Invitation to Speak, Organising Committee 2006)
    • Selected Abstract 'Autophagy and related processes in trypanosomatids: insights from genomic and ..' (Invitation to Speak, BioScience2005 2005)
    • Structural flexibility in Trypanosoma brucei enolase revealed by X-ray crystallography and molecular (Invitation to Speak, Organising Committee 2005)
    • An update on the mysteries of trypanosome fructose 2,6-bisphosphate metabolism (Invitation to Perform, Organising Committee 2004)
    • Analysis of the crystal structure of Trypanosoma brucei enolase (Invitation to Speak, Organising Committee 2003)
    • Preliminary analysis of enzymes of the carbohydrate metabolism of Trypanosoma brucei (Invitation to Speak, Organising Committee 2002)

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