Overview
Our Biomedical Imaging and Biosensing research degree offers the opportunity to undertake a multi-disciplinary research project in physics, chemistry, biology and mathematics. You’ll explore the application of novel imaging and analytical approaches to the study of normal physiology and disease mechanisms, leading to new detection, diagnosis and therapeutic approaches to human disease.
Introduction
The Institute of Systems, Molecular and Integrative Biology (ISMIB) was established to integrate cutting-edge and clinical research across the Faculty of Health and Life Sciences. Programmes of work across ISMIB are varied and are led by world experts in their fields.
The Centre for Preclinical Imaging, part of Liverpool Shared Research Facilities, provides expertise and infrastructure for non-invasive imaging in preclinical models. Our preclinical imaging technologies include high-field magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), computed tomography (CT), magnetic particle imaging (MPI), optical imaging, photo-acoustic imaging, ultrasound and a targeted hyperthermia unit. Novel applications of these imaging technologies and contrast mechanisms are constantly being developed that will aid the further development and refinement of regenerative medicine therapies, and facilitate areas such as developmental biology, neurobiology, physiology, pharmacology and cancer.
Our postgraduate researchers use state-of-the-art technologies. These include (MRI), MPI and PET to enable non-invasive assessment of anatomy and function, optical imaging to assess protein expression and reporter gene expression, ultrasound for the measurement of blood flow and vascularity, and photo-acoustic imaging to facilitate assessment of renal function or cancer hypoxia. All of these have widespread applications for diagnostics and therapeutic interventions in neurology, neurosurgery, oncology, physiology, musculoskeletal biology and other relevant fields.
Research topics
Research topics you could specifically focus on include:
- Monitoring organ structure and function in health and disease, including the kidney, liver, neuro/central nervous system, and imaging cancer
- Tracking cells labelled with contrast agents such as Superparamagnetic Iron Oxide Nanoparticles (SPIONs), for example stem cell tracking
- Development and characterisation of novel contrast agents for increased sensitivity and specificity towards early detection of cancer
- Development of theragnostic agents for treatment of cancer
- Application of magnetic resonance imaging (MRI) to assess electrical conductivity of body tissues
- Development of novel imaging methods including PET and MRI to assess metabolic changes in a chick embryo model of cancer
- Developing cutting-edge, high-resolution imaging of organoids
- Developing strategies for evaluating the safety and efficacy of regenerative medicine therapies
- Utility of diffusion weighted imaging and spectroscopy to assess response to gene therapy, for example for brain tumours and for detection of apoptotic cell death in vivo
- Studying models of memory disorders, schizophrenia and autism.