2024
Barker, E., Milburn, A., Helassa, N., Hammond, D., Sanchez-Soriano, N., Morgan, A., & Barclay, J. (2024). Proximity labelling reveals effects of disease-causing mutation on the DNAJC5/cysteine string protein α interactome.. The Biochemical journal, BCJ20230319. doi:10.1042/bcj20230319DOI: 10.1042/bcj20230319
2023
McCormick, L., Wadmore, K., Milburn, A., Gupta, N., Morris, R., Held, M., . . . Helassa, N. (2023). Long QT syndrome-associated calmodulin variants disrupt the activity of the slow delayed rectifier potassium current. JOURNAL OF PHYSIOLOGY-LONDON, 601(17), 3739-3764. doi:10.1113/JP284994DOI: 10.1113/jp284994
Yaganoglu, S., Kalyviotis, K., Vagena-Pantoula, C., Julich, D., Gaub, B. M., Welling, M., . . . Pantazis, P. (2023). Highly specific and non-invasive imaging of Piezo1-dependent activity across scales using GenEPi. NATURE COMMUNICATIONS, 14(1). doi:10.1038/s41467-023-40134-yDOI: 10.1038/s41467-023-40134-y
Prakash, O., Gupta, N., Milburn, A., McCormick, L., Deugi, V., Fisch, P., . . . Helassa, N. (2023). Calmodulin variant E140G associated with long QT syndrome impairs CaMKIIδ autophosphorylation and L-type calcium channel inactivation. JOURNAL OF BIOLOGICAL CHEMISTRY, 299(1). doi:10.1016/j.jbc.2022.102777DOI: 10.1016/j.jbc.2022.102777
Thomas, N. L., Dart, C., & Helassa, N. (2023). Editorial: The role of calcium and calcium binding proteins in cell physiology and disease. FRONTIERS IN PHYSIOLOGY, 14. doi:10.3389/fphys.2023.1228885DOI: 10.3389/fphys.2023.1228885
2022
Nugues, C., Rajamanoharan, D., Burgoyne, R. D., Haynes, L. P., & Helassa, N. (2022). Lysosome exocytosis is required for mitosis in mammalian cells. Biochemical and Biophysical Research Communications, 626, 211-219. doi:10.1016/j.bbrc.2022.08.024DOI: 10.1016/j.bbrc.2022.08.024
Duerst, C. D., Wiegert, J. S., Schulze, C., Helassa, N., Toeroek, K., & Oertner, T. G. (2022). Vesicular release probability sets the strength of individual Schaffer collateral synapses. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-33565-6DOI: 10.1038/s41467-022-33565-6
Disease-associated calmodulin mutations disrupt L-type Ca2+channel (Cav1.2) activity and CaMKIIdelta phosphorylation in long QT syndrome (Conference Paper)
Helassa, N., Prakash, O., Gupta, N., McCormick, L. F., Antonyuk, S., & Dart, C. (2022). Disease-associated calmodulin mutations disrupt L-type Ca2+channel (Cav1.2) activity and CaMKIIdelta phosphorylation in long QT syndrome. In EUROPEAN HEART JOURNAL Vol. 43 (pp. 2982). Retrieved from https://www.webofscience.com/
Long QT syndrome-associated calmodulin mutations and their interactions with the Kv7.1 voltage-gated potassium channel (Journal article)
McCormick, L. F., Gupta, N., Prakash, O., Lian, L. Y., Dart, C., & Helassa, N. (2022). Long QT syndrome-associated calmodulin mutations and their interactions with the Kv7.1 voltage-gated potassium channel. European Heart Journal, 43(Supplement_2). doi:10.1093/eurheartj/ehac544.2983DOI: 10.1093/eurheartj/ehac544.2983
Long QT Syndrome-Associated Mutations D130V and E141K Affect the Structure-Function Relationship of Calmodulin (Conference Paper)
Wadmore, K., Dart, C., & Helassa, N. (2022). Long QT Syndrome-Associated Mutations D130V and E141K Affect the Structure-Function Relationship of Calmodulin. In ACTA PHYSIOLOGICA Vol. 236 (pp. 586-587). Retrieved from https://www.webofscience.com/
Nugues, C., Helassa, N., & Haynes, L. P. (2022). Mitosis, Focus on Calcium. FRONTIERS IN PHYSIOLOGY, 13. doi:10.3389/fphys.2022.951979DOI: 10.3389/fphys.2022.951979
CALMODULIN MUTATIONS ASSOCIATED WITH LONG QT SYNDROME IMPAIR L-TYPE CALCIUM CHANNEL REGULATION (Conference Paper)
Gupta, N., McCormick, L. F., Prakash, O., Lian, L. -Y., Dart, C., & Helassa, N. (2022). CALMODULIN MUTATIONS ASSOCIATED WITH LONG QT SYNDROME IMPAIR L-TYPE CALCIUM CHANNEL REGULATION. In HEART Vol. 108 (pp. A150-A151). doi:10.1136/heartjnl-2022-BCS.192DOI: 10.1136/heartjnl-2022-BCS.192
LONG QT SYNDROME-ASSOCIATED CALMODULIN MUTATIONS AFFECT INTERACTION WITH L-TYPE CA2+CHANNEL (CAV1.2) AND CAMKII Delta ACTIVITY (Conference Paper)
Prakash, O., Gupta, N., McCormick, L. F., Antonyuk, S., Dart, C., & Helassa, N. (2022). LONG QT SYNDROME-ASSOCIATED CALMODULIN MUTATIONS AFFECT INTERACTION WITH L-TYPE CA2+CHANNEL (CAV1.2) AND CAMKIIΔ ACTIVITY. In HEART Vol. 108 (pp. A148). doi:10.1136/heartjnl-2022-BCS.189DOI: 10.1136/heartjnl-2022-BCS.189
LONG QT SYNDROME-ASSOCIATED CALMODULIN MUTATIONS DISRUPT KV7.1 VOLTAGE-GATED POTASSIUM CHANNEL FUNCTION (Conference Paper)
McCormick, L. F., Gupta, N., Prakash, O., Lian, L. -Y., Dart, C., & Helassa, N. (2022). LONG QT SYNDROME-ASSOCIATED CALMODULIN MUTATIONS DISRUPT KV7.1 VOLTAGE-GATED POTASSIUM CHANNEL FUNCTION. In HEART Vol. 108 (pp. A149). doi:10.1136/heartjnl-2022-BCS.190DOI: 10.1136/heartjnl-2022-BCS.190
CPVT-associated calmodulin variants N53I and A102V dysregulate calcium signalling via different mechanisms (Journal article)
Prakash, O., Held, M., McCormick, L. F., Gupta, N., Lian, L. -Y., Antonyuk, S., . . . Helassa, N. (2022). CPVT-associated calmodulin variants N531 and A102V dysregulate Ca<SUP>2+</SUP> signalling via different mechanisms. JOURNAL OF CELL SCIENCE, 135(2). doi:10.1242/jcs.258796DOI: 10.1242/jcs.258796
2021
Helassa, N. (2021). TSPAN-7 as a key regulator of glucose-stimulated Ca<SUP>2+</SUP> influx and insulin secretion. JOURNAL OF PHYSIOLOGY-LONDON, 599(6), 1733-1734. doi:10.1113/JP281053DOI: 10.1113/jp281053
2020
LQTS-Associated Mutants of Calmodulin Show Disrupted Interaction with L-Type Calcium Channels (Conference Paper)
Gupta, N., McCormick, L. F., Haynes, L. P., Dart, C., & Helassa, N. (2020). LQTS-Associated Mutants of Calmodulin Show Disrupted Interaction with L-Type Calcium Channels. In BIOPHYSICAL JOURNAL Vol. 118 (pp. 405A). Retrieved from https://www.webofscience.com/
Long-QT Syndrome-Associated Calmodulin Mutations and Their Interactions at the K<sub>v</sub>7.1 Potassium Channel (Conference Paper)
McCormick, L. F., Gupta, N., Haynes, L. P., Antonyuk, S., Dart, C., & Helassa, N. (2020). Long-QT Syndrome-Associated Calmodulin Mutations and Their Interactions at the K<sub>v</sub>7.1 Potassium Channel. In BIOPHYSICAL JOURNAL Vol. 118 (pp. 404A). Retrieved from https://www.webofscience.com/
Coates, C., Kerruth, S., Helassa, N., & Torok, K. (2020). Kinetic Mechanisms of Fast Glutamate Sensing by Fluorescent Protein Probes. BIOPHYSICAL JOURNAL, 118(1), 117-127. doi:10.1016/j.bpj.2019.11.006DOI: 10.1016/j.bpj.2019.11.006
2019
Helassa, N., Nugues, C., Rajamanoharan, D., Burgoyne, R. D., & Haynes, L. P. (2019). A centrosome-localized calcium signal is essential for mammalian cell mitosis. The FASEB Journal, 33(12), 14602-14610. doi:10.1096/fj.201901662RDOI: 10.1096/fj.201901662r
Dvorzhak, A., Helassa, N., Torok, K., Schmitz, D., & Grantyn, R. (2019). Single Synapse Indicators of Impaired Glutamate Clearance Derived from Fast iGluu Imaging of Cortical Afferents in the Striatum of Normal and Huntington (Q175) Mice. Journal of Neuroscience, 39(20), 3970-3982. doi:10.1523/JNEUROSCI.2865-18.2019DOI: 10.1523/jneurosci.2865-18.2019
Burgoyne, R. D., Helassa, N., McCue, H. V., & Haynes, L. P. (2019). Calcium Sensors in Neuronal Function and Dysfunction. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 11(5). doi:10.1101/cshperspect.a035154DOI: 10.1101/cshperspect.a035154
Duerst, C. D., Wiegert, J. S., Helassa, N., Kerruth, S., Coates, C., Schulze, C., . . . Oertner, T. G. (2019). High-speed imaging of glutamate release with genetically encoded sensors. NATURE PROTOCOLS, 14(5), 1401-1424. doi:10.1038/s41596-019-0143-9DOI: 10.1038/s41596-019-0143-9
2018
Helassa, N., Dürst, C. D., Coates, C., Kerruth, S., Arif, U., Schulze, C., . . . Török, K. (2018). Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses.. Proceedings of the National Academy of Sciences of the United States of America, 115(21), 5594-5599. doi:10.1073/pnas.1720648115DOI: 10.1073/pnas.1720648115
Helassa, N., Antonyuk, S. V., Lian, L. -Y., Haynes, L. P., & Burgoyne, R. D. (2018). Dystonia-Associated Hippocalcin Mutants Dysregulate Cellular Calcium Influx. In BIOPHYSICAL JOURNAL Vol. 114 (pp. 467A-468A). Retrieved from https://www.webofscience.com/
Helassa, N., Duerst, C., Coates, C., Arif, U., Schulze, C., Wiegert, S., . . . Torok, K. (2018). Novel iGluSnFR Variants Optimised for Rapid Glutamate Imaging. In BIOPHYSICAL JOURNAL Vol. 114 (pp. 153A). Retrieved from http://gateway.webofknowledge.com/DOI: 10.1016/j.bpj.2017.11.858
Diffusion-Limited Glutamate Binding to GluBP is Revealed by Novel Fluorescent Probe (Conference Paper)
Coates, C., Helassa, N., & Torok, K. (2018). Diffusion-Limited Glutamate Binding to GluBP is Revealed by Novel Fluorescent Probe. In BIOPHYSICAL JOURNAL Vol. 114 (pp. 153A). doi:10.1016/j.bpj.2017.11.859DOI: 10.1016/j.bpj.2017.11.859
2017
Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia (Journal article)
Helassa, N., Antonyuk, S. V., Lian, L. -Y., Haynes, L. P., & Burgoyne, R. D. (2017). Biophysical and functional characterization of hippocalcin mutants responsible for human dystonia. Human molecular genetics, 26(13), 2426-2435. doi:10.1093/hmg/ddx133DOI: 10.1093/hmg/ddx133
2016
Design and mechanistic insight into ultrafast calcium indicators for monitoring intracellular calcium dynamics (Journal article)
Helassa, N., Podor, B., Fine, A., & Török, K. (2016). Design and mechanistic insight into ultrafast calcium indicators for monitoring intracellular calcium dynamics. Scientific Reports, 6. doi:10.1038/srep38276DOI: 10.1038/srep38276
Development of Fast-Response GCaMP6 Calcium Sensors for Monitoring Neuronal Action Potential (Conference Paper)
Helassa, N., Podor, B., Fine, A., & Torok, K. (2016). Development of Fast-Response GCaMP6 Calcium Sensors for Monitoring Neuronal Action Potential. In BIOPHYSICAL JOURNAL Vol. 110 (pp. 372A). doi:10.1016/j.bpj.2015.11.2005DOI: 10.1016/j.bpj.2015.11.2005
2015
Fast-Response Calmodulin-Based Fluorescent Indicators Reveal Rapid Intracellular Calcium Dynamics (Journal article)
Helassa, N., Zhang, X. -H., Conte, I., Scaringi, J., Esposito, E., Bradley, J., . . . Török, K. (2015). Fast-Response Calmodulin-Based Fluorescent Indicators Reveal Rapid Intracellular Calcium Dynamics. SCIENTIFIC REPORTS, 5, 15 pages. doi:10.1038/srep15978DOI: 10.1038/srep15978
GCaMP3-Derived Genetically Encoded Probes as Rapid Intracellular Signals for Calcium Dynamics (Conference Paper)
Scaringi, J. A., Helassa, N., Torok, K., & Morad, M. (2015). GCaMP3-Derived Genetically Encoded Probes as Rapid Intracellular Signals for Calcium Dynamics. In BIOPHYSICAL JOURNAL Vol. 108 (pp. 150A). doi:10.1016/j.bpj.2014.11.828DOI: 10.1016/j.bpj.2014.11.828
2014
A novel fluorescent sensor protein for detecting changes in airway surface liquid glucose concentration (Journal article)
Helassa, N., Garnett, J. P., Farrant, M., Khan, F., Pickup, J. C., Hahn, K. M., . . . Baines, D. L. (2014). A novel fluorescent sensor protein for detecting changes in airway surface liquid glucose concentration. Biochemical Journal, 464(2), 213-220. doi:10.1042/BJ20141041DOI: 10.1042/bj20141041
Helassa, N., Esposito, E., Carter, T., Bradley, J., Ogden, D., & Toeroek, K. (2014). Ultrafast Genetically Encoded Calcium Indicators for Visualizing Calcium Flux and Action Potentials. In BIOPHYSICAL JOURNAL Vol. 106 (pp. 242A). doi:10.1016/j.bpj.2013.11.1418DOI: 10.1016/j.bpj.2013.11.1418
2013
Structure, Biological Activity and Environmental Fate of Insecticidal Bt (Bacillus thuringiensis) Cry Proteins of Bacterial and Genetically Modified Plant Origin (Chapter)
Helassa, N., Quiquampoix, H., & Staunton, S. (2013). Structure, Biological Activity and Environmental Fate of Insecticidal Bt (Bacillus thuringiensis) Cry Proteins of Bacterial and Genetically Modified Plant Origin. In MOLECULAR ENVIRONMENTAL SOIL SCIENCE (pp. 49-77). doi:10.1007/978-94-007-4177-5_3DOI: 10.1007/978-94-007-4177-5_3
2012
Peptidoglycan Assembly Machines: The Biochemical Evidence (Journal article)
Zapun, A., Noirclerc-Savoye, M., Helassa, N., & Vernet, T. (2012). Peptidoglycan Assembly Machines: The Biochemical Evidence. MICROBIAL DRUG RESISTANCE, 18(3), 256-260. doi:10.1089/mdr.2011.0236DOI: 10.1089/mdr.2011.0236
The membrane anchor of penicillin‐binding protein PBP2a from Streptococcus pneumoniae influences peptidoglycan chain length (Journal article)
Helassa, N., Vollmer, W., Breukink, E., Vernet, T., & Zapun, A. (2012). The membrane anchor of penicillin-binding protein PBP2a from Streptococcus pneumoniae influences peptidoglycan chain length. FEBS JOURNAL, 279(11), 2071-2081. doi:10.1111/j.1742-4658.2012.08592.xDOI: 10.1111/j.1742-4658.2012.08592.x
2011
Adsorption on montmorillonite prevents oligomerization of Bt Cry1Aa toxin (Journal article)
Helassa, N., Revault, M., Quiquampoix, H., Dejardin, P., Staunton, S., & Noinville, S. (2011). Adsorption on montmorillonite prevents oligomerization of <i>Bt</i> Cry1Aa toxin. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 356(2), 718-725. doi:10.1016/j.jcis.2011.01.064DOI: 10.1016/j.jcis.2011.01.064
Effects of physicochemical interactions and microbial activity on the persistence of Cry1Aa Bt (<i>Bacillus thuringiensis</i>) toxin in soil (Journal article)
Helassa, N., M'Charek, A., Quiquampoix, H., Noinville, S., Dejardin, P., Frutos, R., & Staunton, S. (2011). Effects of physicochemical interactions and microbial activity on the persistence of Cry1Aa Bt (<i>Bacillus thuringiensis</i>) toxin in soil. SOIL BIOLOGY & BIOCHEMISTRY, 43(5), 1089-1097. doi:10.1016/j.soilbio.2011.01.030DOI: 10.1016/j.soilbio.2011.01.030
2010
Adsorption of Alexa-Labeled Bt Toxin on Mica, Glass, and Hydrophobized Glass: Study by Normal Scanning Confocal Fluorescence (Journal article)
Janot, J. -M., Boissiere, M., Thami, T., Tronel-Peyroz, E., Helassa, N., Noinville, S., . . . Dejardin, P. (2010). Adsorption of Alexa-Labeled Bt Toxin on Mica, Glass, and Hydrophobized Glass: Study by Normal Scanning Confocal Fluorescence. BIOMACROMOLECULES, 11(6), 1661-1666. doi:10.1021/bm100313nDOI: 10.1021/bm100313n
Mobility of adsorbed Cry1Aa insecticidal toxin from Bacillus thuringiensis (Bt) on montmorillonite measured by fluorescence recovery after photobleaching (FRAP) (Journal article)
Helassa, N., Daudin, G., Noinville, S., Janot, J. -M., Dejardin, P., Staunton, S., & Quiquampoix, H. (2010). Mobility of adsorbed Cry1Aa insecticidal toxin from Bacillus thuringiensis (Bt) on montmorillonite measured by fluorescence recovery after photobleaching (FRAP). PHILOSOPHICAL MAGAZINE, 90(17-18), 2365-2371. doi:10.1080/14786431003636071DOI: 10.1080/14786431003636071
Interaction of Bttoxin with Organo-mineral Surfaces and Consequences for Its Fate in the Environment (Chapter)
Helassa, N., Noinville, S., Dejardin, P., Jano, J. -M., Quiquampoix, H., & Staunton, S. (2010). Interaction of Bttoxin with Organo-mineral Surfaces and Consequences for Its Fate in the Environment. In MOLECULAR ENVIRONMENTAL SOIL SCIENCE AT THE INTERFACES IN THE EARTH’S CRITICAL ZONE (pp. 187-189). doi:10.1007/978-3-642-05297-2_56DOI: 10.1007/978-3-642-05297-2_56
2009
Adsorption and desorption of monomeric Bt (Bacillus thuringiensis) Cry1Aa toxin on montmorillonite and kaolinite (Journal article)
Helassa, N., Quiquampoix, H., Noinville, S., Szponarski, W., & Staunton, S. (2009). Adsorption and desorption of monomeric Bt (<i>Bacillus thuringiensis</i>) Cry1Aa toxin on montmorillonite and kaolinite. SOIL BIOLOGY & BIOCHEMISTRY, 41(3), 498-504. doi:10.1016/j.soilbio.2008.12.008DOI: 10.1016/j.soilbio.2008.12.008
