Dr Jeff Barclay Ph.D

Lecturer Cellular and Molecular Physiology

    Publications

    2019

    IDENTIFYING AND CONFIRMING THE FUNCTIONAL VALIDITY OF GENETIC LOCI IN ALCOHOL CONSUMPTION USING UK BIOBANK (Conference Paper)

    Thompson, A., Cook, J. P., Kinnunen, T., Barclay, J., Morris, A. P., & Pirmohamed, M. (2019). IDENTIFYING AND CONFIRMING THE FUNCTIONAL VALIDITY OF GENETIC LOCI IN ALCOHOL CONSUMPTION USING UK BIOBANK. In ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Vol. 43 (pp. 203A). Retrieved from http://gateway.webofknowledge.com/

    2018

    A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action (Journal article)

    Wong, S. Q., Jones, A., Dodd, S., Grimes, D., Barclay, J. W., Marson, A. G., . . . Morgan, A. (2018). A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action. JOURNAL OF NEUROSCIENCE METHODS, 309, 132-142. doi:10.1016/j.jneumeth.2018.09.004

    DOI: 10.1016/j.jneumeth.2018.09.004

    alpha-Methyl-alpha-phenylsuccinimide ameliorates neurodegeneration in a C-elegans model of TDP-43 proteinopathy (Journal article)

    Wong, S. Q., Pontifex, M. G., Phelan, M. M., Pidathala, C., Kraemer, B. C., Barclay, J. W., . . . Morgan, A. (2018). alpha-Methyl-alpha-phenylsuccinimide ameliorates neurodegeneration in a C-elegans model of TDP-43 proteinopathy. NEUROBIOLOGY OF DISEASE, 118, 40-54. doi:10.1016/j.nbd.2018.06.013

    DOI: 10.1016/j.nbd.2018.06.013

    2017

    Ethanol Stimulates Locomotion via a G(alpha s)-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans (Journal article)

    Johnson, J. R., Edwards, M. R., Davies, H., Newman, D., Holden, W., Jenkins, R. E., . . . Barclay, J. W. (2017). Ethanol Stimulates Locomotion via a G(alpha s)-Signaling Pathway in IL2 Neurons in Caenorhabditis elegans. GENETICS, 207(3), 1023-1039. doi:10.1534/genetics.117.300119

    DOI: 10.1534/genetics.117.300119

    2016

    Interaction of ARF-1.1 and neuronal calcium sensor-1 in the control of the temperature-dependency of locomotion in Caenorhabditis elegans (Journal article)

    Todd, P. A. C., Mccue, H. V., Haynes, L. P., Barclay, J. W., & Burgoyne, R. D. (2016). Interaction of ARF-1.1 and neuronal calcium sensor-1 in the control of the temperature-dependency of locomotion in Caenorhabditis elegans. SCIENTIFIC REPORTS, 6. doi:10.1038/srep30023

    DOI: 10.1038/srep30023

    Small Heat Shock Proteins Are Novel Common Determinants of Alcohol and Nicotine Sensitivity in Caenorhabditis elegans (Journal article)

    Johnson, J. R., Rajamanoharan, D., McCue, H. V., Rankin, K., & Barclay, J. W. (2016). Small Heat Shock Proteins Are Novel Common Determinants of Alcohol and Nicotine Sensitivity in Caenorhabditis elegans. GENETICS, 202(3), 1013-+. doi:10.1534/genetics.115.185025

    DOI: 10.1534/genetics.115.185025

    2015

    Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components (Journal article)

    McCue, H. V., Chen, X., Barclay, J. W., Morgan, A., & Burgoyne, R. D. (2015). Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components. SCIENTIFIC REPORTS, 5. doi:10.1038/srep14392

    DOI: 10.1038/srep14392

    Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression (Journal article)

    Chen, X., McCuef, H. V., Wong, S. Q., Kashyap, S. S., Kraemer, B. C., Barclay, J. W., . . . Morgan, A. (2015). Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression. MOLECULAR NEURODEGENERATION, 10. doi:10.1186/s13024-015-0046-3

    DOI: 10.1186/s13024-015-0046-3

    Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression (vol 10, 51, 2015) (Journal article)

    Chen, X., McCue, H. V., Wong, S. Q., Kashyap, S. S., Kraemer, B. C., Barclay, J. W., . . . Morgan, A. (2015). Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression (vol 10, 51, 2015). MOLECULAR NEURODEGENERATION, 10. doi:10.1186/s13024-015-0051-6

    DOI: 10.1186/s13024-015-0051-6

    Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases (Journal article)

    Chen, X., Barclay, J. W., Burgoyne, R. D., & Morgan, A. (2015). Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases. CHEMISTRY CENTRAL JOURNAL, 9. doi:10.1186/s13065-015-0143-y

    DOI: 10.1186/s13065-015-0143-y

    2014

    Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol (Journal article)

    Kashyap, S. S., Johnson, J. R., McCue, H. V., Chen, X., Edmonds, M. J., Ayala, M., . . . Morgan, A. (2014). Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol. HUMAN MOLECULAR GENETICS, 23(22), 5916-5927. doi:10.1093/hmg/ddu316

    DOI: 10.1093/hmg/ddu316

    2013

    Using Caenorhabditis elegans to fight human neurodegenerative diseases (Journal article)

    Chen, X., Kraemer, B., Barclay, J. W., Burgoyne, R., & Morgan, A. (2013). Using Caenorhabditis elegans to fight human neurodegenerative diseases. Molecular Neurodegeneration. doi:10.1186/1750-1326-8-S1-P12

    DOI: 10.1186/1750-1326-8-S1-P12

    Identification of key structural elements for neuronal calcium sensor-1 function in the regulation of the temperature-dependency of locomotion in C. elegans (Journal article)

    Martin, V. M., Johnson, J. R., Haynes, L. P., Barclay, J. W., & Burgoyne, R. D. (2013). Identification of key structural elements for neuronal calcium sensor-1 function in the regulation of the temperature-dependency of locomotion in C. elegans. MOLECULAR BRAIN, 6. doi:10.1186/1756-6606-6-39

    DOI: 10.1186/1756-6606-6-39

    Rab-3 and unc-18 Interactions in Alcohol Sensitivity Are Distinct from Synaptic Transmission (Journal article)

    Johnson, J. R., Kashyap, S., Rankin, K., & Barclay, J. W. (2013). Rab-3 and unc-18 Interactions in Alcohol Sensitivity Are Distinct from Synaptic Transmission. PLOS ONE, 8(11). doi:10.1371/journal.pone.0081117

    DOI: 10.1371/journal.pone.0081117

    2012

    Neurotransmitter release mechanisms studied in Caenorhabditis elegans (Journal article)

    Barclay, J. W., Morgan, A., & Burgoyne, R. D. (2012). Neurotransmitter release mechanisms studied in Caenorhabditis elegans. CELL CALCIUM, 52(3-4), 289-295. doi:10.1016/j.ceca.2012.03.005

    DOI: 10.1016/j.ceca.2012.03.005

    PKC-2 Phosphorylation of UNC-18 Ser322 in AFD Neurons Regulates Temperature Dependency of Locomotion (Journal article)

    Edwards, M. R., Johnson, J. R., Rankin, K., Jenkins, R. E., Maguire, C., Morgan, A., . . . Barclay, J. W. (2012). PKC-2 Phosphorylation of UNC-18 Ser322 in AFD Neurons Regulates Temperature Dependency of Locomotion. JOURNAL OF NEUROSCIENCE, 32(20), 7042-7051. doi:10.1523/JNEUROSCI.4029-11.2012

    DOI: 10.1523/JNEUROSCI.4029-11.2012

    2011

    Munc18-1 Tuning of Vesicle Merger and Fusion Pore Properties (Journal article)

    Jorgacevski, J., Potokar, M., Grilc, S., Kreft, M., Liu, W., Barclay, J. W., . . . Zorec, R. (2011). Munc18-1 Tuning of Vesicle Merger and Fusion Pore Properties. JOURNAL OF NEUROSCIENCE, 31(24), 9055-9066. doi:10.1523/JNEUROSCI.0185-11.2011

    DOI: 10.1523/JNEUROSCI.0185-11.2011

    Structure-Function Study of Mammalian Munc18-1 and C. elegans UNC-18 Implicates Domain 3b in the Regulation of Exocytosis (Journal article)

    Graham, M. E., Prescott, G. R., Johnson, J. R., Jones, M., Walmesley, A., Haynes, L. P., . . . Barclay, J. W. (2011). Structure-Function Study of Mammalian Munc18-1 and C. elegans UNC-18 Implicates Domain 3b in the Regulation of Exocytosis. PLOS ONE, 6(3). doi:10.1371/journal.pone.0017999

    DOI: 10.1371/journal.pone.0017999

    2010

    Caenorhabditis elegans: a useful tool to decipher neurodegenerative pathways (Journal article)

    Johnson, J. R., Jenn, R. C., Barclay, J. W., Burgoyne, R. D., & Morgan, A. (2010). Caenorhabditis elegans: a useful tool to decipher neurodegenerative pathways. BIOCHEMICAL SOCIETY TRANSACTIONS, 38, 559-563. doi:10.1042/BST0380559

    DOI: 10.1042/BST0380559

    Presynaptic targets for acute ethanol sensitivity (Journal article)

    Barclay, J. W., Graham, M. E., Edwards, M. R., Johnson, J. R., Morgan, A., & Burgoyne, R. D. (2010). Presynaptic targets for acute ethanol sensitivity. BIOCHEMICAL SOCIETY TRANSACTIONS, 38, 172-176. doi:10.1042/BST0380172

    DOI: 10.1042/BST0380172

    2009

    Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans (Journal article)

    Johnson, J. R., Ferdek, P., Lian, L. -Y., Barclay, J. W., Burgoyne, R. D., & Morgan, A. (2009). Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans. BIOCHEMICAL JOURNAL, 418, 73-80. doi:10.1042/BJ20081956

    DOI: 10.1042/BJ20081956

    The Functions of Munc18-1 in Regulated Exocytosis (Journal article)

    Burgoyne, R. D., Barclay, J. W., Ciufo, L. E., Graham, M. E., Handley, M. T. W., & Morgan, A. (2009). The Functions of Munc18-1 in Regulated Exocytosis. MECHANISMS OF EXOCYTOSIS, 1152, 76-86. doi:10.1111/j.1749-6632.2008.03987.x

    DOI: 10.1111/j.1749-6632.2008.03987.x

    UNC-18 Modulates Ethanol Sensitivity in Caenorhabditis elegans (Journal article)

    Graham, M. E., Edwards, M. R., Holden-Dye, L., Morgan, A., Burgoyne, R. D., & Barclay, J. W. (2009). UNC-18 Modulates Ethanol Sensitivity in Caenorhabditis elegans. MOLECULAR BIOLOGY OF THE CELL, 20(1), 43-55. doi:10.1091/mbc.E08-07-0689

    DOI: 10.1091/mbc.E08-07-0689

    2008

    A random mutagenesis approach to isolate dominant-negative yeast Sec1 mutants reveals a functional role for domain 3a in yeast and mammalian Sec1/Munc18 proteins (Journal article)

    Boyd, A., Ciufo, L. F., Barclay, J. W., Graham, M. E., Haynes, L. P., Doherty, M. K., . . . Morgan, A. (2008). A random mutagenesis approach to isolate dominant-negative yeast Sec1 mutants reveals a functional role for domain 3a in yeast and mammalian Sec1/Munc18 proteins. GENETICS, 180(1), 165-178. doi:10.1534/genetics.108.090423

    DOI: 10.1534/genetics.108.090423

    S-nitrosylation of syntaxin 1 at Cys(145) is a regulatory switch controlling Munc18-1 binding (Journal article)

    Palmer, Z. J., Duncan, R. R., Johnson, J. R., Lian, L. -Y., Mello, L. V., Booth, D., . . . Morgan, A. (2008). S-nitrosylation of syntaxin 1 at Cys(145) is a regulatory switch controlling Munc18-1 binding. BIOCHEMICAL JOURNAL, 413, 479-491. doi:10.1042/BJ20080069

    DOI: 10.1042/BJ20080069

    Munc-18-1 Regulates the Initial Release Rate of Exocytosis (Journal article)

    Barclay, J. W. (2008). Munc-18-1 Regulates the Initial Release Rate of Exocytosis. Biophysical Journal, 94(3), 1084-1093. doi:10.1529/biophysj.107.111203

    DOI: 10.1529/biophysj.107.111203

    A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3 (Journal article)

    Graham, M. E., Handley, M. T. W., Barclay, J. W., Ciufo, L. F., Barrow, S. L., Morgan, A., & Burgoyne, R. D. (2008). A gain-of-function mutant of Munc18-1 stimulates secretory granule recruitment and exocytosis and reveals a direct interaction of Munc18-1 with Rab3. BIOCHEMICAL JOURNAL, 409, 407-416. doi:10.1042/BJ20071094

    DOI: 10.1042/BJ20071094

    2006

    Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size (Journal article)

    Evans, G. J. O., Barclay, J. W., Prescott, G. R., Jo, S. R., Burgoyne, R. D., Birnbaum, M. J., & Morgan, A. (2006). Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(3), 1564-1572. doi:10.1074/jbc.M503628200

    DOI: 10.1074/jbc.M503628200

    2005

    Calcium-dependent regulation of exocytosis (Journal article)

    Barclay, J. W., Morgan, A., & Burgoyne, R. D. (2005). Calcium-dependent regulation of exocytosis. CELL CALCIUM, 38(3-4), 343-353. doi:10.1016/j.ceca.2005.06.012

    DOI: 10.1016/j.ceca.2005.06.012

    Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions (Journal article)

    Ciufo, L. F., Barclay, J. W., Burgoyne, R. D., & Morgan, A. (2005). Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions. MOLECULAR BIOLOGY OF THE CELL, 16(2), 470-482. doi:10.1091/mbc.E04-08-0685

    DOI: 10.1091/mbc.E04-08-0685

    Regulation of exocytosis by protein kinase C (Journal article)

    Morgan, A., Burgoyne, R. D., Barclay, J. W., Craig, T. J., Prescott, G. R., Ciufo, L. F., . . . Graham, M. E. (2005). Regulation of exocytosis by protein kinase C. BIOCHEMICAL SOCIETY TRANSACTIONS, 33, 1341-1344. doi:10.1042/BST0331341

    DOI: 10.1042/BST0331341

    2004

    Regulation of the fusion pore conductance during exocytosis by cyclin-dependent kinase 5 (Journal article)

    Barclay, J. W., Aldea, M., Craig, T. J., Morgan, A., & Burgoyne, R. D. (2004). Regulation of the fusion pore conductance during exocytosis by cyclin-dependent kinase 5. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(40), 41495-41503. doi:10.1074/jbc.M406670200

    DOI: 10.1074/jbc.M406670200

    Syntaxin/Munc18 interactions in the late events during vesicle fusion and release in exocytosis (Journal article)

    Graham, M. E., Barclay, J. W., & Burgoyne, R. D. (2004). Syntaxin/Munc18 interactions in the late events during vesicle fusion and release in exocytosis. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(31), 32751-32760. doi:10.1074/jbc.M400827200

    DOI: 10.1074/jbc.M400827200

    2003

    Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis (Journal article)

    Barclay, J. W., Craig, T. J., Fisher, R. J., Ciufo, L. F., Evans, G. J. O., Morgan, A., & Burgoyne, R. D. (2003). Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(12), 10538-10545. doi:10.1074/jbc.M211114200

    DOI: 10.1074/jbc.M211114200

    Role for calcium in heat shock-mediated synaptic thermoprotection inDrosophila larvae (Journal article)

    Barclay, J. W., & Robertson, R. M. (2003). Role for calcium in heat shock-mediated synaptic thermoprotection inDrosophila larvae. Journal of Neurobiology, 56(4), 360-371. doi:10.1002/neu.10247

    DOI: 10.1002/neu.10247

    2002

    Enhancement of presynaptic performance in transgenicDrosophila overexpressing heat shock protein Hsp70 (Journal article)

    Karunanithi, S., Barclay, J. W., Brown, I. R., Robertson, R. M., & Atwood, H. L. (2002). Enhancement of presynaptic performance in transgenicDrosophila overexpressing heat shock protein Hsp70. Synapse, 44(1), 8-14. doi:10.1002/syn.10048

    DOI: 10.1002/syn.10048

    Impairment of central pattern generation in Drosophila cysteine string protein mutants (Journal article)

    Barclay, J., Atwood, H., & Robertson, M. (2002). Impairment of central pattern generation in Drosophila cysteine string protein mutants. Journal of Comparative Physiology A: Sensory, Neural, and Behavioral Physiology, 188(1), 71-78. doi:10.1007/s00359-002-0279-9

    DOI: 10.1007/s00359-002-0279-9

    Splitting the quantum: regulation of quantal release during vesicle fusion (Journal article)

    Burgoyne, R. D., & Barclay, J. W. (2002). Splitting the quantum: regulation of quantal release during vesicle fusion. TRENDS IN NEUROSCIENCES, 25(4), 176-178. doi:10.1016/S0166-2236(00)02126-3

    DOI: 10.1016/S0166-2236(00)02126-3

    2001

    Enhancement of Short-Term Synaptic Plasticity by Prior Environmental Stress (Journal article)

    Barclay, J. W., & Robertson, R. M. (2001). Enhancement of Short-Term Synaptic Plasticity by Prior Environmental Stress. Journal of Neurophysiology, 85(3), 1332-1335. doi:10.1152/jn.2001.85.3.1332

    DOI: 10.1152/jn.2001.85.3.1332

    2000

    Heat-shock-induced thermoprotection of hindleg motor control in the locust (Journal article)

    Barclay, J. W., & Robertson, R. M. (2000). Heat-shock-induced thermoprotection of hindleg motor control in the locust. J Exp Biol, 203(Pt 5), 941-950. Retrieved from http://www.ncbi.nlm.nih.gov/

    1999

    Neuroprotection at Drosophila synapses conferred by prior heat shock (Journal article)

    Karunanithi, S., Barclay, J. W., Robertson, R. M., Brown, I. R., & Atwood, H. L. (1999). Neuroprotection at Drosophila synapses conferred by prior heat shock. J Neurosci, 19(11), 4360-4369. Retrieved from http://www.ncbi.nlm.nih.gov/