Photo of Dr Dan Carr

Dr Dan Carr BSc (Hons) MSc PhD FHEA

Lecturer Molecular and Clinical Pharmacology

Publications

2019

Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink. (Journal article)

Carr, D. F., Francis, B., Jorgensen, A. L., Zhang, E., Chinoy, H., Heckbert, S. R., . . . Pirmohamed, M. (2019). Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink.. Clinical pharmacology and therapeutics, 106(6), 1353-1361. doi:10.1002/cpt.1557

DOI: 10.1002/cpt.1557

Serum and blister-fluid elevation and decreased epidermal content of high-mobility group box 1 protein in drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (Journal article)

Carr, D. F., Wang, C. -W., Bellon, T., Ressel, L., Nwikue, G., Shrivastava, V., . . . Pirmohamed, M. (2019). Serum and blister-fluid elevation and decreased epidermal content of high-mobility group box 1 protein in drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. BRITISH JOURNAL OF DERMATOLOGY, 181(1), 166-174. doi:10.1111/bjd.17610

DOI: 10.1111/bjd.17610

Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing. (Journal article)

Floyd, J. S., Bloch, K. M., Brody, J. A., Maroteau, C., Siddiqui, M. K., Gregory, R., . . . PREDICTION-ADR Consortium and EUDRAGENE. (2019). Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing.. PloS one, 14(6), e0218115. doi:10.1371/journal.pone.0218115

DOI: 10.1371/journal.pone.0218115

Software for Dosage Individualization of Voriconazole: a Prospective Clinical Study. (Journal article)

Hope, W., Johnstone, G., Cicconi, S., Felton, T., Goodwin, J., Whalley, S., . . . Neely, M. (2019). Software for Dosage Individualization of Voriconazole: a Prospective Clinical Study.. Antimicrobial agents and chemotherapy. doi:10.1128/aac.02353-18

DOI: 10.1128/aac.02353-18

2018

Critical assessment of approaches for molecular docking to elucidate associations of HLA alleles with adverse drug reactions (Journal article)

Ramsbottom, K. A., Carr, D. F., Jones, A. R., & Rigden, D. J. (2018). Critical assessment of approaches for molecular docking to elucidate associations of HLA alleles with adverse drug reactions. MOLECULAR IMMUNOLOGY, 101, 488-499. doi:10.1016/j.molimm.2018.08.003

DOI: 10.1016/j.molimm.2018.08.003

A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis (Journal article)

Foulkes, A. C., Watson, D. S., Carr, D. F., Kenny, J. G., Slidel, T., Parslew, R., . . . Consortium, P. S. O. R. T. (2019). A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 139(1), 100-107. doi:10.1016/j.jid.2018.04.041

DOI: 10.1016/j.jid.2018.04.041

Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study (Journal article)

Hawcutt, D. B., Francis, B., Carr, D. F., Jorgensen, A. L., Yin, P., Wallin, N., . . . Pirmohamed, M. (2018). Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study. LANCET RESPIRATORY MEDICINE, 6(6), 442-450. doi:10.1016/S2213-2600(18)30058-4

DOI: 10.1016/S2213-2600(18)30058-4

ABCG2 rs2231142 and NR1I2 rs2472677 influence dolutegravir concentrations in plasma. (Conference Paper)

Elliot, E., Neary, M. G., Else, L., Khoo, S., Moyle, G., Carr, D., . . . Boffito, M. (n.d.). ABCG2 rs2231142 and NR1I2 rs2472677 influence dolutegravir concentrations in plasma.. In CROI. Boston, MA, USA.

Biomarkers of adverse drug reactions (Journal article)

Carr, D. F., & Pirmohamed, M. (2018). Biomarkers of adverse drug reactions. EXPERIMENTAL BIOLOGY AND MEDICINE, 243(3), 291-299. doi:10.1177/1535370217733425

DOI: 10.1177/1535370217733425

2017

A common missense variant of LILRB5 is associated with statin intolerance and myalgia (Journal article)

Siddiqui, M. K., Maroteau, C., Veluchamy, A., Tornio, A., Tavendale, R., Carr, F., . . . Consortium, P. R. E. D. I. C. T. I. O. N. -A. D. R. (2017). A common missense variant of LILRB5 is associated with statin intolerance and myalgia. EUROPEAN HEART JOURNAL, 38(48), 3569-3U31. doi:10.1093/eurheartj/ehx467

DOI: 10.1093/eurheartj/ehx467

The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis (Journal article)

Cliff, J., Jorgensen, A. L., Lord, R., Azam, F., Cossar, L., Carr, D. F., & Pirmohamed, M. (2017). The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 120, 127-140. doi:10.1016/j.critrevonc.2017.09.009

DOI: 10.1016/j.critrevonc.2017.09.009

Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population (Journal article)

Carr, D. F., Bourgeois, S., Chaponda, M., Takeshita, L. Y., Morris, A. P., Castro, E. M. C., . . . Pirmohamed, M. (2017). Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 72(4), 1152-1162. doi:10.1093/jac/dkw545

DOI: 10.1093/jac/dkw545

Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury (Journal article)

Carr, D. F., Ayehunie, S., Davies, A., Duckworth, C. A., French, S., Hall, N., . . . Pirmohamed, M. (2017). Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury. PHARMACOLOGY & THERAPEUTICS, 172, 181-194. doi:10.1016/j.pharmthera.2017.01.002

DOI: 10.1016/j.pharmthera.2017.01.002

2016

A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity (Presentation material)

Yip, V. L. M., Meng, X., Maggs, J. L., Pertinez, H., Carr, D. F., Marson, A. G., . . . Pirmohamed, M. (2016). A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity. London, UK.

A candidate gene study for oxaliplatin induced chronic peripheral neuropathy (OICPN) based on a prior genome wide association study (GWAS) (Conference Paper)

Cliff, J. R., Carr, D. F., Lord, R. H., Jorgensen, A. L., & Pirmohamed, M. (2016). A candidate gene study for oxaliplatin induced chronic peripheral neuropathy (OICPN) based on a prior genome wide association study (GWAS). In ANNALS OF ONCOLOGY Vol. 27. doi:10.1093/annonc/mdw392.54

DOI: 10.1093/annonc/mdw392.54

An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters (Journal article)

Mirza, N., Vasieva, O., Appleton, R., Burn, S., Carr, D., Crooks, D., . . . Pirmohamed, M. (2016). An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters. EPILEPSIA, 57(9), 1467-1474. doi:10.1111/epi.13473

DOI: 10.1111/epi.13473

Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G -> T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis (Journal article)

Nightingale, S., Chau, T. T. H., Fisher, M., Nelson, M., Winston, A., Else, L., . . . Grp, P. -V. S. (2016). Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G -> T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 60(8), 4511-4518. doi:10.1128/AAC.00280-16

DOI: 10.1128/AAC.00280-16

2015

Advances in the Pharmacogenomics of Adverse Drug Reactions (Journal article)

Collins, S. L., Carr, D. F., & Pirmohamed, M. (2016). Advances in the Pharmacogenomics of Adverse Drug Reactions. DRUG SAFETY, 39(1), 15-27. doi:10.1007/s40264-015-0367-8

DOI: 10.1007/s40264-015-0367-8

A comprehensive omics assessment of etanercept therapy for psoriasis (Conference Paper)

Foulkes, A., Rattray, N. J. W., Correa, E., Trivedi, D. K., Carr, D. F., Maratou, K., . . . Warren, R. (2015). A comprehensive omics assessment of etanercept therapy for psoriasis. In BRITISH JOURNAL OF DERMATOLOGY Vol. 173 (pp. 12). Retrieved from http://gateway.webofknowledge.com/

Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy (Conference Paper)

O'Hara, A., Burkitt, M. D., Carr, D. F., Alfirevic, A., Moore, A. R., Murugesan, S. V., . . . Pritchard, D. M. (2015). Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy. In GASTROENTEROLOGY Vol. 148 (pp. S566). Retrieved from http://gateway.webofknowledge.com/

Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy (Journal article)

O'Hara, A., Burkitt, M., Carr, D., Alfirevic, A., Moore, A., Murugesan, S., . . . Pritchard, M. (2015). Su1978 Polymorphisms in the RELB Gene Identify a Haplotype Associated With Reduced Risk of Pangastric Atrophy.

HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis (Journal article)

Castro, E. M. C., Carr, D. F., Jorgensen, A. L., Alfirevic, A., & Pirmohamed, M. (2015). HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis. PHARMACOGENETICS AND GENOMICS, 25(4), 186-198. doi:10.1097/FPC.0000000000000124

DOI: 10.1097/FPC.0000000000000124

Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality (Journal article)

Mirza, N., Appleton, R., Burn, S., Carr, D., Crooks, D., du Plessis, D., . . . Pirmohamed, M. (2015). Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality. HUMAN MOLECULAR GENETICS, 24(15), 4306-4316. doi:10.1093/hmg/ddv163

DOI: 10.1093/hmg/ddv163

2014

Pharmacogenomic signatures of response to etanercept therapy for psoriasis (Conference Paper)

Foulkes, A. C., Carr, D. F., Al-Sharqi, A., Parslew, R., Pirmohamed, M., Reynolds, N. J., . . . Warren, R. B. (2014). Pharmacogenomic signatures of response to etanercept therapy for psoriasis. In BRITISH JOURNAL OF DERMATOLOGY Vol. 171 (pp. E114-E115). Retrieved from http://gateway.webofknowledge.com/

Phenotype Standardization for Statin-Induced Myotoxicity (Journal article)

Alfirevic, A., Neely, D., Armitage, J., Chinoy, H., Cooper, R. G., Laaksonen, R., . . . Pirmohamed, M. (2014). Phenotype Standardization for Statin-Induced Myotoxicity. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(4), 470-476. doi:10.1038/clpt.2014.121

DOI: 10.1038/clpt.2014.121

CYP2B6 c.983T > C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations (Journal article)

Carr, D. F., Chaponda, M., Castro, E. M. C., Jorgensen, A. L., Khoo, S., Van Oosterhout, J. J., . . . Pirmohamed, M. (2014). CYP2B6 c.983T > C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 69(12), 3329-3334. doi:10.1093/jac/dku315

DOI: 10.1093/jac/dku315

Assessing the reliability of exome sequencing to detect the filaggrin null mutations R501X and 2282del4 (Conference Paper)

Thompson, B., Hawcutt, D., Carr, D., Bloch, K., Swale, A., Smyth, R., & Pirmohamed, M. (2014). Assessing the reliability of exome sequencing to detect the filaggrin null mutations R501X and 2282del4. In BRITISH JOURNAL OF DERMATOLOGY Vol. 171 (pp. 115-116). Retrieved from http://gateway.webofknowledge.com/

Folate Augmentation of Treatment-Evaluation for Depression (FolATED): randomised trial and economic evaluation (Journal article)

Bedson, E., Bell, D., Carr, D., Carter, B., Hughes, D., Jorgensen, A., . . . Trialists, F. (2014). Folate Augmentation of Treatment-Evaluation for Depression (FolATED): randomised trial and economic evaluation. HEALTH TECHNOLOGY ASSESSMENT, 18(48), 1-+. doi:10.3310/hta18480

DOI: 10.3310/hta18480

Pharmacogenetics in the treatment of chronic lymphocytic leukemia: what does the future hold? (Journal article)

Johnson, G. G., Carr, D. F., Pirmohamed, M., & Pettitt, A. R. (2014). Pharmacogenetics in the treatment of chronic lymphocytic leukemia: what does the future hold?. PHARMACOGENOMICS, 15(7), 897-900. doi:10.2217/pgs.14.60

DOI: 10.2217/pgs.14.60

Electronic health records for biological sample collection: feasibility study of statin- induced myopathy using the Clinical Practice Research Datalink (Journal article)

O'Meara, H., Carr, D. F., Evely, J., Hobbs, M., McCann, G., van Staa, T., & Pirmohamed, M. (2014). Electronic health records for biological sample collection: feasibility study of statin- induced myopathy using the Clinical Practice Research Datalink. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 77(5), 831-838. doi:10.1111/bcp.12269

DOI: 10.1111/bcp.12269

GATM gene variants and statin myopathy risk (Journal article)

Carr, D. F., Alfirevic, A., Johnson, R., Chinoy, H., van Staa, T., & Pirmohamed, M. (2014). GATM gene variants and statin myopathy risk. NATURE, 513(7518), E1. doi:10.1038/nature13628

DOI: 10.1038/nature13628

Pharmacogenomics: Current State-of-the-Art (Journal article)

Carr, D. F., Alfirevic, A., & Pirmohamed, M. (2014). Pharmacogenomics: Current State-of-the-Art. GENES, 5(2), 430-443. doi:10.3390/genes5020430

DOI: 10.3390/genes5020430

Predictors and outcomes of increases in creatine phosphokinase concentrations or rhabdomyolysis risk during statin treatment (Journal article)

van Staa, T. P., Carr, D. F., O'Meara, H., McCann, G., & Pirmohamed, M. (2014). Predictors and outcomes of increases in creatine phosphokinase concentrations or rhabdomyolysis risk during statin treatment. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 78(3), 649-659. doi:10.1111/bcp.12367

DOI: 10.1111/bcp.12367

2013

Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study (Journal article)

Jones, R. P., Sutton, P., Greensmith, R. M. D., Santoyo-Castelazo, A., Carr, D. F., Jenkins, R., . . . Kitteringham, N. R. (2013). Hepatic activation of irinotecan predicts tumour response in patients with colorectal liver metastases treated with DEBIRI: exploratory findings from a phase II study. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 72(2), 359-368. doi:10.1007/s00280-013-2199-5

DOI: 10.1007/s00280-013-2199-5

The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK (Journal article)

Alfirevic, A., Carr, D. F., Miyajima, F., Pushpakom, S., Sutton, L., Jorgensen, A. L., & Pirmohamed, M. (2013). The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK. PHARMACOGENOMICS, 14(8), 861-867. doi:10.2217/PGS.13.73

DOI: 10.2217/PGS.13.73

Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population (Journal article)

Carr, D. F., Chaponda, M., Jorgensen, A. L., Castro, E. C., van Oosterhout, J. J., Khoo, S. H., . . . Pirmohamed, M. (2013). Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population. CLINICAL INFECTIOUS DISEASES, 56(9), 1330-1339. doi:10.1093/cid/cit021

DOI: 10.1093/cid/cit021

CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia (Journal article)

Johnson, G. G., Lin, K., Cox, T. F., Oates, M., Sibson, D. R., Eccles, R., . . . Pettitt, A. R. (2013). CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia. BLOOD, 122(26), 4253-4258. doi:10.1182/blood-2013-07-516666

DOI: 10.1182/blood-2013-07-516666

CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia (Journal article)

Johnson, G. G., Lin, K., Cox, T. F., Oates, M., Sibson, D. R., Eccles, R., . . . Pettitt, A. R. (2013). CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia. Blood, 122(26), 4253-4258. doi:10.1182/blood-2013-07-516666

DOI: 10.1182/blood-2013-07-516666

CYP2C19*17 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease (Journal article)

Musumba, C. O., Jorgensen, A., Sutton, L., Van Eker, D., Zhang, E., O'Hara, N., . . . Pirmohamed, M. (2013). CYP2C19*17 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease. CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(2), 195-203. doi:10.1038/clpt.2012.215

DOI: 10.1038/clpt.2012.215

Population Pharmacokinetic and Pharmacogenetic Analysis of Nevirapine in Hypersensitive and Tolerant HIV-Infected Patients from Malawi (Journal article)

Dickinson, L., Chaponda, M., Carr, D. F., van Oosterhout, J. J., Kumwenda, J., Lalloo, D. G., . . . Khoo, S. H. (2014). Population Pharmacokinetic and Pharmacogenetic Analysis of Nevirapine in Hypersensitive and Tolerant HIV-Infected Patients from Malawi. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(2), 706-712. doi:10.1128/AAC.02069-13

DOI: 10.1128/AAC.02069-13

SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink (Journal article)

Carr, D. F., O'Meara, H., Jorgensen, A. L., Campbell, J., Hobbs, M., McCann, G., . . . Pirmohamed, M. (2013). SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink. CLINICAL PHARMACOLOGY & THERAPEUTICS, 94(6), 695-701. doi:10.1038/clpt.2013.161

DOI: 10.1038/clpt.2013.161

2011

Report on the 8th Annual Cold Spring Harbor/Wellcome Trust meeting on Pharmacogenomics and Personalized Medicine. (Journal article)

Carr, D. F., & Alfirevic, A. (2011). Report on the 8th Annual Cold Spring Harbor/Wellcome Trust meeting on Pharmacogenomics and Personalized Medicine.. Pharmacogenomics, 12(3), 315-317. doi:10.2217/pgs.10.217

DOI: 10.2217/pgs.10.217

The IL1RN Promoter rs4251961 Correlates with IL-1 Receptor Antagonist Concentrations in Human Infection and Is Differentially Regulated by GATA-1 (Journal article)

Carrol, E. D., Payton, A., Payne, D., Miyajima, F., Chaponda, M., Mankhambo, L. A., . . . Ollier, W. E. (2011). The IL1RN Promoter rs4251961 Correlates with IL-1 Receptor Antagonist Concentrations in Human Infection and Is Differentially Regulated by GATA-1. JOURNAL OF IMMUNOLOGY, 186(4), 2329-2335. doi:10.4049/jimmunol.1002402

DOI: 10.4049/jimmunol.1002402

2010

Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort (Journal article)

Carr, D. F., la Porte, C. J. L., Pirmohamed, M., Owen, A., & Cortes, C. P. (2010). Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 65(9), 1889-1893. doi:10.1093/jac/dkq260

DOI: 10.1093/jac/dkq260

Population pharmacokinetic and pharmacogenetic analysis of nevirapine in hypersensitive and tolerant HIV-infected patients from Malawi. (Conference Paper)

Dickinson, L., Chaponda, M., Carr, D., van Oosterhout, J. J., Kumwenda, J., Lalloo, D. G., . . . Khoo, S. H. (2010). Population pharmacokinetic and pharmacogenetic analysis of nevirapine in hypersensitive and tolerant HIV-infected patients from Malawi.. In Journal of the International AIDS Society Vol. 13 (pp. P181). doi:10.1186/1758-2652-13-S4-P181

DOI: 10.1186/1758-2652-13-S4-P181

2009

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review (Journal article)

Carr, D. F., Whiteley, G., Alfirevic, A., Pirmohamed, M., & Team, F. S. (2009). Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review. PHARMACOGENOMICS JOURNAL, 9(5), 291-305. doi:10.1038/tpj.2009.29

DOI: 10.1038/tpj.2009.29

2007

Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity (Journal article)

Carr, D. F., Alfirevic, A., Tugwood, J. D., Barratt, B. J., Sherwood, J., Smith, J., . . . Park, B. K. (2007). Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. PHARMACOGENETICS AND GENOMICS, 17(11), 961-972. doi:10.1097/FPC.0b013e3282f00919

DOI: 10.1097/FPC.0b013e3282f00919

Tacrine-induced liver damage: an analysis of 19 candidate genes (Journal article)

Alfirevic, A., Mills, T., Carr, D., Barratt, B. J., Jawaid, A., Sherwood, J., . . . Pirmohamed, M. (2007). Tacrine-induced liver damage: an analysis of 19 candidate genes. PHARMACOGENETICS AND GENOMICS, 17(12), 1091-1100. doi:10.1097/FPC.0b013e3282f1f12b

DOI: 10.1097/FPC.0b013e3282f1f12b

2006

Identification of IL-6 as a candidate gene in tacrine-induced hepatotoxicity: Association with elevated serum transaminases (Journal article)

Carr, D. F., Alfirevic, A., Sherwood, J., Tugwood, J. D., Park, B. K., & Pirmohamed, M. (2006). Identification of IL-6 as a candidate gene in tacrine-induced hepatotoxicity: Association with elevated serum transaminases. DRUG METABOLISM REVIEWS, 38, 54. Retrieved from http://gateway.webofknowledge.com/