2023
Metabolomics 2022 workshop report: state of QA/QC best practices in LC–MS-based untargeted metabolomics, informed through mQACC community engagement initiatives (Journal article)
Dunn, W. B., Kuligowski, J., Lewis, M., Mosley, J. D., Schock, T., Ulmer Holland, C., . . . Vuckovic, D. (n.d.). Metabolomics 2022 workshop report: state of QA/QC best practices in LC–MS-based untargeted metabolomics, informed through mQACC community engagement initiatives. Metabolomics, 19(11). doi:10.1007/s11306-023-02060-4DOI: 10.1007/s11306-023-02060-4
Alimajstorovic, Z., Mitchell, J. L., Yiangou, A., Hancox, T., Southam, A. D., Grech, O., . . . Sinclair, A. J. (2023). Determining the role of novel metabolic pathways in driving intracranial pressure reduction after weight loss.. Brain communications, 5(5), fcad272. doi:10.1093/braincomms/fcad272DOI: 10.1093/braincomms/fcad272
Muhamadali, H., Winder, C. L., Dunn, W. B., & Goodacre, R. (2023). Unlocking the secrets of the microbiome: exploring the dynamic microbial interplay with humans through metabolomics and their manipulation for synthetic biology applications.. The Biochemical journal, 480(12), 891-908. doi:10.1042/bcj20210534DOI: 10.1042/bcj20210534
Alimajstorovic, Z., Mollan, S. P., Grech, O., Mitchell, J. L., Yiangou, A., Thaller, M., . . . Sinclair, A. J. (2023). Dysregulation of Amino Acid, Lipid, and Acylpyruvate Metabolism in Idiopathic Intracranial Hypertension: A Non-targeted Case Control and Longitudinal Metabolomic Study. JOURNAL OF PROTEOME RESEARCH, 22(4), 1127-1137. doi:10.1021/acs.jproteome.2c00449DOI: 10.1021/acs.jproteome.2c00449
Stavrou, V., Fultang, L., Booth, S., De Simone, D., Bartnik, A., Scarpa, U., . . . De Santo, C. (2023). Invariant NKT cells metabolically adapt to the acute myeloid leukaemia environment.. Cancer immunology, immunotherapy : CII, 72(3), 543-560. doi:10.1007/s00262-022-03268-4DOI: 10.1007/s00262-022-03268-4
Sarmad, S., Viant, M. R., Dunn, W. B., Goodacre, R., Wilson, I. D., Chappell, K. E., . . . UK Consortium on Metabolic Phenotyping (MAP/UK). (2023). A proposed framework to evaluate the quality and reliability of targeted metabolomics assays from the UK Consortium on Metabolic Phenotyping (MAP/UK).. Nature protocols. doi:10.1038/s41596-022-00801-8DOI: 10.1038/s41596-022-00801-8
2022
Providing metabolomics education and training: pedagogy and considerations (Journal article)
Winder, C. L., Witting, M., Tugizimana, F., Dunn, W. B., & Reinke, S. N. (2022). Providing metabolomics education and training: pedagogy and considerations. METABOLOMICS, 18(12). doi:10.1007/s11306-022-01957-wDOI: 10.1007/s11306-022-01957-w
Critical assessment of chromatographic metadata in publicly available metabolomics data repositories (Journal article)
Harrieder, E. -M., Kretschmer, F., Dunn, W., Boecker, S., & Witting, M. (2022). Critical assessment of chromatographic metadata in publicly available metabolomics data repositories. METABOLOMICS, 18(12). doi:10.1007/s11306-022-01956-xDOI: 10.1007/s11306-022-01956-x
Kirwan, J. A., Gika, H., Beger, R. D., Bearden, D., Dunn, W. B., Goodacre, R., . . . Wilson, I. D. (2022). Quality assurance and quality control reporting in untargeted metabolic phenotyping: mQACC recommendations for analytical quality management. METABOLOMICS, 18(9). doi:10.1007/s11306-022-01926-3DOI: 10.1007/s11306-022-01926-3
Wilhelmsen, A., Davies, A., Mallinson, J., Pabla, P., Jones, R., Palmer, E. A., . . . Tsintzas, K. (2022). Acute effects of prior dietary fat ingestion on postprandial metabolic responses to protein and carbohydrate co-ingestion in overweight and obese men: A randomised crossover trial. CLINICAL NUTRITION, 41(8), 1623-1635. doi:10.1016/j.clnu.2022.06.022DOI: 10.1016/j.clnu.2022.06.022
Allaway, D., Alexander, J. E., Carvell-Miller, L. J., Reynolds, R. M., Winder, C. L., Weber, R. J. M., . . . Dunn, W. B. (2022). Suitability of Dried Blood Spots for Accelerating Veterinary Biobank Collections and Identifying Metabolomics Biomarkers With Minimal Resources. FRONTIERS IN VETERINARY SCIENCE, 9. doi:10.3389/fvets.2022.887163DOI: 10.3389/fvets.2022.887163
Wilcock, D. J., Badrock, A. P., Wong, C. W., Owen, R., Guerin, M., Southam, A. D., . . . Hurlstone, A. F. L. (2022). Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached.. Cell reports, 39(12), 110995. doi:10.1016/j.celrep.2022.110995DOI: 10.1016/j.celrep.2022.110995
Lippa, K. A., Aristizabal-Henao, J. J., Beger, R. D., Bowden, J. A., Broeckling, C., Beecher, C., . . . Ubhi, B. K. (2022). Reference materials for MS-based untargeted metabolomics and lipidomics: a review by the metabolomics quality assurance and quality control consortium (mQACC).. Metabolomics : Official journal of the Metabolomic Society, 18(4), 24. doi:10.1007/s11306-021-01848-6DOI: 10.1007/s11306-021-01848-6
2021
Chorioamnionitis alters lung surfactant lipidome in newborns with respiratory distress syndrome (Journal article)
Giambelluca, S., Verlato, G., Simonato, M., Vedovelli, L., Bonadies, L., Najdekr, L., . . . Cogo, P. (2021). Chorioamnionitis alters lung surfactant lipidome in newborns with respiratory distress syndrome. PEDIATRIC RESEARCH, 90(5), 1039-1043. doi:10.1038/s41390-021-01371-3DOI: 10.1038/s41390-021-01371-3
Chacko, S., Mamas, M. A., El-Omar, M., Simon, D., Haseeb, S., Fath-Ordoubadi, F., . . . Dunn, W. B. (2021). Perturbations in cardiac metabolism in a human model of acute myocardial ischaemia.. Metabolomics : Official journal of the Metabolomic Society, 17(9), 76. doi:10.1007/s11306-021-01827-xDOI: 10.1007/s11306-021-01827-x
An improved strategy for analysis of lipid molecules utilising a reversed phase C<sub>30</sub> UHPLC column and scheduled MS/MS acquisition (Journal article)
Jankevics, A., Jenkins, A., Dunn, W. B., & Najdekr, L. (2021). An improved strategy for analysis of lipid molecules utilising a reversed phase C<sub>30</sub> UHPLC column and scheduled MS/MS acquisition. TALANTA, 229. doi:10.1016/j.talanta.2021.122262DOI: 10.1016/j.talanta.2021.122262
Alkhalefah, A., Dunn, W. B., Allwood, J. W., Parry, K. L., Houghton, F. D., Ashton, N., & Glazier, J. D. (2021). Maternal intermittent fasting during pregnancy induces fetal growth restriction and down-regulated placental system A amino acid transport in the rat.. Clinical science (London, England : 1979), 135(11), 1445-1466. doi:10.1042/cs20210137DOI: 10.1042/cs20210137
Hancox, T. P. M., Skene, D. J., Dallmann, R., & Dunn, W. B. (n.d.). Tick-Tock Consider the Clock: The Influence of Circadian and External Cycles on Time of Day Variation in the Human Metabolome—A Review. Metabolites, 11(5), 328. doi:10.3390/metabo11050328DOI: 10.3390/metabo11050328
Xuan, W. -K., Rodriguez-Blanco, G., Southam, A. D., Winder, C. L., Dunn, W. B., Ivens, A., & Piddocka, L. J. V. (2021). Metabolomics Reveal Potential Natural Substrates of AcrB in <i>Escherichia coli</i> and <i>Salmonella enterica</i> Serovar Typhimurium. MBIO, 12(2). doi:10.1128/mBio.00109-21DOI: 10.1128/mBio.00109-21
Improvement in the Prediction of Neonatal Hypoxic-Ischemic Encephalopathy with the Integration of Umbilical Cord Metabolites and Current Clinical Makers (Journal article)
O'Boyle, D. S., Dunn, W. B., O'Neill, D., Kirwan, J. A., Broadhurst, D. I., Hallberg, B., . . . Murray, D. M. (2021). Improvement in the Prediction of Neonatal Hypoxic-Ischemic Encephalopathy with the Integration of Umbilical Cord Metabolites and Current Clinical Makers. JOURNAL OF PEDIATRICS, 229, 175-+. doi:10.1016/j.jpeds.2020.09.065DOI: 10.1016/j.jpeds.2020.09.065
Metabolic characterisation of disturbances in the <i>APOC3</i>/triglyceride-rich lipoprotein pathway through sample-based recall by genotype (vol 16, 69, 2020) (Journal article)
Corbin, L. J., Hughes, D. A., Chetwynd, A. J., Taylor, A. E., Southam, A. D., Jankevics, A., . . . Timpson, N. J. (2021). Metabolic characterisation of disturbances in the <i>APOC3</i>/triglyceride-rich lipoprotein pathway through sample-based recall by genotype (vol 16, 69, 2020). METABOLOMICS, 17(2). doi:10.1007/s11306-020-01765-0DOI: 10.1007/s11306-020-01765-0
Thorne, L. S., Rochford, G., Williams, T. D., Southam, A. D., Rodriguez-Blanco, G., Dunn, W. B., & Hodges, N. J. (2021). Cytoglobin protects cancer cells from apoptosis by regulation of mitochondrial cardiolipin.. Scientific reports, 11(1), 985. doi:10.1038/s41598-020-79830-wDOI: 10.1038/s41598-020-79830-w
Characterization of Monophasic Solvent-Based Tissue Extractions for the Detection of Polar Metabolites and Lipids Applying Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry Clinical Metabolic Phenotyping Assays (Journal article)
Southam, A. D., Pursell, H., Frigerio, G., Jankevics, A., Weber, R. J. M., & Dunn, W. B. (2021). Characterization of Monophasic Solvent-Based Tissue Extractions for the Detection of Polar Metabolites and Lipids Applying Ultrahigh-Performance Liquid Chromatography-Mass Spectrometry Clinical Metabolic Phenotyping Assays. JOURNAL OF PROTEOME RESEARCH, 20(1), 831-840. doi:10.1021/acs.jproteome.0c00660DOI: 10.1021/acs.jproteome.0c00660
2020
Assessment of human plasma and urine sample preparation for reproducible and high-throughput UHPLC-MS clinical metabolic phenotyping (Journal article)
Southam, A. D., Haglington, L. D., Najdekr, L., Jankevics, A., Weber, R. J. M., & Dunn, W. B. (2020). Assessment of human plasma and urine sample preparation for reproducible and high-throughput UHPLC-MS clinical metabolic phenotyping. ANALYST, 145(20), 6511-6523. doi:10.1039/d0an01319fDOI: 10.1039/d0an01319f
Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC-MS based untargeted metabolomics practitioners (Journal article)
Evans, A. M., O'Donovan, C., Playdon, M., Beecher, C., Beger, R. D., Bowden, J. A., . . . Vuckovic, D. (2020). Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC-MS based untargeted metabolomics practitioners. METABOLOMICS, 16(10). doi:10.1007/s11306-020-01728-5DOI: 10.1007/s11306-020-01728-5
Bilateral Remote Ischaemic Conditioning in Children (BRICC) trial: protocol for a two-centre, double-blind, randomised controlled trial in young children undergoing cardiac surgery (Journal article)
Drury, N. E., Bi, R., Woolley, R. L., Stickley, J., Morris, K. P., Montgomerie, J., . . . Jones, T. J. (2020). Bilateral Remote Ischaemic Conditioning in Children (BRICC) trial: protocol for a two-centre, double-blind, randomised controlled trial in young children undergoing cardiac surgery. BMJ OPEN, 10(10). doi:10.1136/bmjopen-2020-042176DOI: 10.1136/bmjopen-2020-042176
Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity (Journal article)
Fultang, L., Booth, S., Yogev, O., da Costa, B. M., Tubb, V., Panetti, S., . . . De Santo, C. (2020). Metabolic engineering against the arginine microenvironment enhances CAR-T cell proliferation and therapeutic activity. BLOOD, 136(10), 1155-1160. doi:10.1182/blood.2019004500DOI: 10.1182/blood.2019004500
Barlow, J. P., Karstoft, K., Vigelsø, A., Gram, M., Helge, J. W., Dela, F., . . . Solomon, T. P. J. (2020). Beta-aminoisobutyric acid is released by contracting human skeletal muscle and lowers insulin release from INS-1 832/3 cells by mediating mitochondrial energy metabolism.. Metabolism open, 7, 100053. doi:10.1016/j.metop.2020.100053DOI: 10.1016/j.metop.2020.100053
Urinary biomonitoring of subjects with different smoking habits. Part II: an untargeted metabolomic approach and the comparison with the targeted measurement of mercapturic acids (Journal article)
Frigerio, G., Mercadante, R., Campo, L., Polledri, E., Boniardi, L., Olgiati, L., . . . Fustinoni, S. (2020). Urinary biomonitoring of subjects with different smoking habits. Part II: an untargeted metabolomic approach and the comparison with the targeted measurement of mercapturic acids. TOXICOLOGY LETTERS, 329, 56-66. doi:10.1016/j.toxlet.2020.03.020DOI: 10.1016/j.toxlet.2020.03.020
Intestinal permeability in participants with thermal injury: A case series from a prospective, longitudinal study (HESTIA) (Journal article)
Tipple, C., Moiemen, N. S., Ioannou, C., Paglione, M., Goodson, S., McGee, K., . . . Berger, S. (2020). Intestinal permeability in participants with thermal injury: A case series from a prospective, longitudinal study (HESTIA). Burns Open, 4(3), 94-102. doi:10.1016/j.burnso.2020.05.005DOI: 10.1016/j.burnso.2020.05.005
Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing (Journal article)
Wilkinson, D. J., Rodriguez-Blanco, G., Dunn, W. B., Phillips, B. E., Williams, J. P., Greenhaff, P. L., . . . Atherton, P. J. (2020). Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing. AGING-US, 12(13), 12517-12533. doi:10.18632/aging.103513DOI: 10.18632/aging.103513
Metabolic characterisation of disturbances in the<i>APOC3</i>/triglyceride-rich lipoprotein pathway through sample-based recall by genotype (Journal article)
Corbin, L. J., Hughes, D. A., Chetwynd, A. J., Taylor, A. E., Southam, A. D., Jankevics, A., . . . Timpson, N. J. (2020). Metabolic characterisation of disturbances in the<i>APOC3</i>/triglyceride-rich lipoprotein pathway through sample-based recall by genotype. METABOLOMICS, 16(6). doi:10.1007/s11306-020-01689-9DOI: 10.1007/s11306-020-01689-9
Multi-Omics Analysis of Diabetic Heart Disease in the <i>db/db</i> Model Reveals Potential Targets for Treatment by a Longevity-Associated Gene (Journal article)
Faulkner, A., Dang, Z., Avolio, E., Thomas, A. C., Batstone, T., Lloyd, G. R., . . . Madeddu, P. (2020). Multi-Omics Analysis of Diabetic Heart Disease in the <i>db/db</i> Model Reveals Potential Targets for Treatment by a Longevity-Associated Gene. CELLS, 9(5). doi:10.3390/cells9051283DOI: 10.3390/cells9051283
SERUM METABOLOMIC PROFILES IDENTIFY ALTERATIONS IN LIPID METABOLISM IN PREMENARCHAL GIRLS AT INCREASED RISK FOR PCOS (Conference Paper)
Torchen, L., Dunn, W., Arlt, W., & Dunaif, A. (2020). SERUM METABOLOMIC PROFILES IDENTIFY ALTERATIONS IN LIPID METABOLISM IN PREMENARCHAL GIRLS AT INCREASED RISK FOR PCOS. In JOURNAL OF INVESTIGATIVE MEDICINE Vol. 68 (pp. 1073-1074). doi:10.1136/jim-2020-MW.67DOI: 10.1136/jim-2020-MW.67
The metabolomic profile of endometrial receptivity in recurrent miscarriage (Conference Paper)
Craciunas, L., Chu, J., Pickering, O., Mohiyiddeen, L., Dunn, W., & Coomarasamy, A. (2020). The metabolomic profile of endometrial receptivity in recurrent miscarriage. In HUMAN REPRODUCTION Vol. 35 (pp. 90-91). Retrieved from https://www.webofscience.com/
2019
Comparison of modified Matyash method to conventional solvent systems for polar metabolite and lipid extractions (vol 1037, pg 301, 2018) (Journal article)
Sostare, E., Di Guida, R., Kirwan, J., Chalal, K., Palmer, E., Dunn, W. B., & Viant, M. R. (2019). Comparison of modified Matyash method to conventional solvent systems for polar metabolite and lipid extractions (vol 1037, pg 301, 2018). ANALYTICA CHIMICA ACTA, 1091, 169. doi:10.1016/j.aca.2019.09.069DOI: 10.1016/j.aca.2019.09.069
International Ring Trial of a High Resolution Targeted Metabolomics and Lipidomics Platform for Serum and Plasma Analysis (Journal article)
Thompson, J. W., Adams, K. J., Adamski, J., Asad, Y., Borts, D., Bowden, J. A., . . . Moseley, M. A. (2019). International Ring Trial of a High Resolution Targeted Metabolomics and Lipidomics Platform for Serum and Plasma Analysis. ANALYTICAL CHEMISTRY, 91(22), 14407-14416. doi:10.1021/acs.analchem.9b02908DOI: 10.1021/acs.analchem.9b02908
Investigation of the 12-Month Stability of Dried Blood and Urine Spots Applying Untargeted UHPLC-MS Metabolomic Assays (Journal article)
Palmer, E. A., Cooper, H. J., & Dunn, W. B. (2019). Investigation of the 12-Month Stability of Dried Blood and Urine Spots Applying Untargeted UHPLC-MS Metabolomic Assays. ANALYTICAL CHEMISTRY, 91(22), 14306-14313. doi:10.1021/acs.analchem.9b02577DOI: 10.1021/acs.analchem.9b02577
From mass to metabolite in human untargeted metabolomics: Recent advances in annotation of metabolites applying liquid chromatography-mass spectrometry data (Journal article)
Nash, W. J., & Dunn, W. B. (2019). From mass to metabolite in human untargeted metabolomics: Recent advances in annotation of metabolites applying liquid chromatography-mass spectrometry data. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 120. doi:10.1016/j.trac.2018.11.022DOI: 10.1016/j.trac.2018.11.022
Systematic Review: Clinical Metabolomics to Forecast Outcomes in Liver Transplantation Surgery (Journal article)
Attard, J. A., Dunn, W. B., Mergental, H., Mirza, D. F., Afford, S. C., & Perera, T. P. R. (2019). Systematic Review: Clinical Metabolomics to Forecast Outcomes in Liver Transplantation Surgery. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY, 23(10), 463-476. doi:10.1089/omi.2019.0086DOI: 10.1089/omi.2019.0086
Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases (Journal article)
Jeffery, H. C., Hunter, S., Humphreys, E. H., Bhogal, R., Wawman, R. E., Birtwistle, J., . . . Oo, Y. H. (2019). Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases. JOURNAL OF IMMUNOLOGY, 203(5), 1151-1159. doi:10.4049/jimmunol.1800455DOI: 10.4049/jimmunol.1800455
Multiple metabolic pathways are predictive of ricin intoxication in a rat model (Journal article)
D'Elia, R. V., Goodchild, S. A., Winder, C. L., Southam, A. D., Weber, R. J. M., Stahl, F. M., . . . Dunn, W. B. (2019). Multiple metabolic pathways are predictive of ricin intoxication in a rat model. METABOLOMICS, 15(7). doi:10.1007/s11306-019-1547-9DOI: 10.1007/s11306-019-1547-9
Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish (Journal article)
Henderson, F., Johnston, H. R., Badrock, A. P., Jones, E. A., Forster, D., Nagaraju, R. T., . . . Hurlstone, A. (2019). Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish. CANCER RESEARCH, 79(9), 2136-2151. doi:10.1158/0008-5472.CAN-18-2409DOI: 10.1158/0008-5472.CAN-18-2409
Gestational route to healthy birth (GaRBH): protocol for an Indian prospective cohort study (Journal article)
Gupta, V., Saxena, R., Walia, G. K., Agarwal, T., Vats, H., Dunn, W., . . . Sachdeva, M. P. (2019). Gestational route to healthy birth (GaRBH): protocol for an Indian prospective cohort study. BMJ OPEN, 9(4). doi:10.1136/bmjopen-2018-025395DOI: 10.1136/bmjopen-2018-025395
Towards quality assurance and quality control in untargeted metabolomics studies (Journal article)
Beger, R. D., Dunn, W. B., Bandukwala, A., Bethan, B., Broadhurst, D., Clish, C. B., . . . Zanetti, K. A. (2019). Towards quality assurance and quality control in untargeted metabolomics studies. METABOLOMICS, 15(1). doi:10.1007/s11306-018-1460-7DOI: 10.1007/s11306-018-1460-7
Collection of Untargeted Metabolomic Data for Mammalian Urine Applying HILIC and Reversed Phase Ultra Performance Liquid Chromatography Methods Coupled to a Q Exactive Mass Spectrometer. (Chapter)
Najdekr, L., Blanco, G. R., & Dunn, W. B. (2019). Collection of Untargeted Metabolomic Data for Mammalian Urine Applying HILIC and Reversed Phase Ultra Performance Liquid Chromatography Methods Coupled to a Q Exactive Mass Spectrometer.. In Unknown Book (Vol. 1996, pp. 1-15). doi:10.1007/978-1-4939-9488-5_1DOI: 10.1007/978-1-4939-9488-5_1
Untargeted metabolomic analysis and pathway discovery in perinatal asphyxia and hypoxic-ischaemic encephalopathy (Journal article)
Denihan, N. M., Kirwan, J. A., Walsh, B. H., Dunn, W. B., Broadhurst, D. I., Boylan, G. B., & Murray, D. M. (2019). Untargeted metabolomic analysis and pathway discovery in perinatal asphyxia and hypoxic-ischaemic encephalopathy. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 39(1), 147-162. doi:10.1177/0271678X17726502DOI: 10.1177/0271678X17726502
Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial: Metabolomics of Ex Vivo Normothermically Machine Perfused Livers Discloses Molecular Signatures Predictive of Graft Viability and Post Transplant Outcomes. (Conference Paper)
Attard, J., Dunn, W., Wallace, L., Laing, R., Boteon, Y., Mergental, H., . . . Afford, S. (2019). Viability Testing and Transplantation of Marginal Donor Livers (VITTAL) Trial: Metabolomics of Ex Vivo Normothermically Machine Perfused Livers Discloses Molecular Signatures Predictive of Graft Viability and Post Transplant Outcomes.. In AMERICAN JOURNAL OF TRANSPLANTATION Vol. 19 (pp. 341). Retrieved from https://www.webofscience.com/
2018
Comparison of modified Matyash method to conventional solvent systems for polar metabolite and lipid extractions. (Journal article)
Sostare, J., Di Guida, R., Kirwan, J., Chalal, K., Palmer, E., Dunn, W. B., & Viant, M. R. (2018). Comparison of modified Matyash method to conventional solvent systems for polar metabolite and lipid extractions.. Analytica chimica acta, 1037, 301-315. doi:10.1016/j.aca.2018.03.019DOI: 10.1016/j.aca.2018.03.019
Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma. (Journal article)
Chortis, V., Taylor, A. E., Doig, C. L., Walsh, M. D., Meimaridou, E., Jenkinson, C., . . . Foster, P. A. (2018). Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma.. Endocrinology, 159(8), 2836-2849. doi:10.1210/en.2018-00014DOI: 10.1210/en.2018-00014
Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for "Precision Medicine and Pharmacometabolomics Task Group"-The Metabolomics Society Initiative). (Journal article)
Kirwan, J. A., Brennan, L., Broadhurst, D., Fiehn, O., Cascante, M., Dunn, W. B., . . . Velagapudi, V. (2018). Preanalytical Processing and Biobanking Procedures of Biological Samples for Metabolomics Research: A White Paper, Community Perspective (for "Precision Medicine and Pharmacometabolomics Task Group"-The Metabolomics Society Initiative).. Clinical chemistry, 64(8), 1158-1182. doi:10.1373/clinchem.2018.287045DOI: 10.1373/clinchem.2018.287045
Lyall, M. J., Cartier, J., Thomson, J. P., Cameron, K., Meseguer-Ripolles, J., O'Duibhir, E., . . . Drake, A. J. (2018). Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells.. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 373(1750), 20170362. doi:10.1098/rstb.2017.0362DOI: 10.1098/rstb.2017.0362
Broadhurst, D., Goodacre, R., Reinke, S. N., Kuligowski, J., Wilson, I. D., Lewis, M. R., & Dunn, W. B. (2018). Guidelines and considerations for the use of system suitability and quality control samples in mass spectrometry assays applied in untargeted clinical metabolomic studies. METABOLOMICS, 14(6). doi:10.1007/s11306-018-1367-3DOI: 10.1007/s11306-018-1367-3
Hulme, C. H., Stevens, A., Dunn, W., Heazell, A. E. P., Hollywood, K., Begley, P., . . . Myers, J. E. (2018). Identification of the functional pathways altered by placental cell exposure to high glucose: lessons from the transcript and metabolite interactome.. Scientific reports, 8(1), 5270. doi:10.1038/s41598-018-22535-yDOI: 10.1038/s41598-018-22535-y
The Role of Ultra Performance Liquid Chromatography-Mass Spectrometry in Metabolic Phenotyping (Chapter)
Dunn, W. B., & Lewis, M. R. (2019). The Role of Ultra Performance Liquid Chromatography-Mass Spectrometry in Metabolic Phenotyping. In The Handbook of Metabolic Phenotyping (pp. 97-136). Elsevier. doi:10.1016/b978-0-12-812293-8.00003-7DOI: 10.1016/b978-0-12-812293-8.00003-7
2017
Pérez-Schindler, J., Kanhere, A., Edwards, L., Allwood, J. W., Dunn, W. B., Schenk, S., & Philp, A. (2017). Exercise and high-fat feeding remodel transcript-metabolite interactive networks in mouse skeletal muscle.. Scientific reports, 7(1), 13485. doi:10.1038/s41598-017-14081-wDOI: 10.1038/s41598-017-14081-w
Adipose tissue and metabolic and inflammatory responses to stroke are altered in obese mice. (Journal article)
Haley, M. J., Mullard, G., Hollywood, K. A., Cooper, G. J., Dunn, W. B., & Lawrence, C. B. (2017). Adipose tissue and metabolic and inflammatory responses to stroke are altered in obese mice.. Disease models & mechanisms, 10(10), 1229-1243. doi:10.1242/dmm.030411DOI: 10.1242/dmm.030411
AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome (Journal article)
O'Reilly, M. W., Kempegowda, P., Walsh, M., Taylor, A. E., Manolopoulos, K. N., Allwood, J. W., . . . Arlt, W. (2017). AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 102(9), 3327-3339. doi:10.1210/jc.2017-00947DOI: 10.1210/jc.2017-00947
Quality assurance and quality control processes: summary of a metabolomics community questionnaire (Journal article)
Dunn, W. B., Broadhurst, D. I., Edison, A., Guillou, C., Viant, M. R., Bearden, D. W., & Beger, R. D. (2017). Quality assurance and quality control processes: summary of a metabolomics community questionnaire. Metabolomics, 13(5). doi:10.1007/s11306-017-1188-9DOI: 10.1007/s11306-017-1188-9
msPurity: Automated Evaluation of Precursor Ion Purity for Mass Spectrometry-Based Fragmentation in Metabolomics (Journal article)
Lawson, T. N., Weber, R. J. M., Jones, M. R., Chetwynd, A. J., Rodriguez-Blanco, G., Di Guida, R., . . . Dunn, W. B. (2017). msPurity: Automated Evaluation of Precursor Ion Purity for Mass Spectrometry-Based Fragmentation in Metabolomics. ANALYTICAL CHEMISTRY, 89(4), 2432-2439. doi:10.1021/acs.analchem.6b04358DOI: 10.1021/acs.analchem.6b04358
Computational tools and workflows in metabolomics: An international survey highlights the opportunity for harmonisation through Galaxy (Journal article)
Weber, R. J. M., Lawson, T. N., Salek, R. M., Ebbels, T. M. D., Glen, R. C., Goodacre, R., . . . Viant, M. R. (2017). Computational tools and workflows in metabolomics: An international survey highlights the opportunity for harmonisation through Galaxy. METABOLOMICS, 13(2). doi:10.1007/s11306-016-1147-xDOI: 10.1007/s11306-016-1147-x
How close are we to complete annotation of metabolomes? (Journal article)
Viant, M. R., Kurland, I. J., Jones, M. R., & Dunn, W. B. (2017). How close are we to complete annotation of metabolomes?. CURRENT OPINION IN CHEMICAL BIOLOGY, 36, 64-69. doi:10.1016/j.cbpa.2017.01.001DOI: 10.1016/j.cbpa.2017.01.001
MALDI-MS of drugs: Profiling, imaging, and steps towards quantitative analysis (Journal article)
Turker, S. D., Dunn, W. B., & Wilkie, J. (2017). MALDI-MS of drugs: Profiling, imaging, and steps towards quantitative analysis. Applied Spectroscopy Reviews, 52(1), 73-99. doi:10.1080/05704928.2016.1207659DOI: 10.1080/05704928.2016.1207659
Collection and Preparation of Clinical Samples for Metabolomics. (Chapter)
Chetwynd, A. J., Dunn, W. B., & Rodriguez-Blanco, G. (2017). Collection and Preparation of Clinical Samples for Metabolomics.. In Unknown Book (Vol. 965, pp. 19-44). doi:10.1007/978-3-319-47656-8_2DOI: 10.1007/978-3-319-47656-8_2
ELIXIR-UK role in bioinformatics training at the national level and across ELIXIR (Journal article)
Larcombe, L., Hendricusdottir, R., Attwood, T. K., Bacall, F., Beard, N., Bellis, L. J., . . . Rustici, G. (n.d.). ELIXIR-UK role in bioinformatics training at the national level and across ELIXIR. F1000Research, 6, 952. doi:10.12688/f1000research.11837.1DOI: 10.12688/f1000research.11837.1
The future of metabolomics in ELIXIR (Journal article)
van Rijswijk, M., Beirnaert, C., Caron, C., Cascante, M., Dominguez, V., Dunn, W. B., . . . Steinbeck, C. (n.d.). The future of metabolomics in ELIXIR. F1000Research, 6, 1649. doi:10.12688/f1000research.12342.1DOI: 10.12688/f1000research.12342.1
van Rijswijk, M., Beirnaert, C., Caron, C., Cascante, M., Dominguez, V., Dunn, W. B., . . . Steinbeck, C. (2017). The future of metabolomics in ELIXIR. . F1000Research, 6, ELIXIR-1649. doi:10.12688/f1000research.12342.2DOI: 10.12688/f1000research.12342.2
2016
Metabolomics enables precision medicine: "A White Paper, Community Perspective" (Journal article)
Beger, R. D., Dunn, W., Schmidt, M. A., Gross, S. S., Kirwan, J. A., Cascante, M., . . . Kaddurah-Daouk, R. (2016). Metabolomics enables precision medicine: "A White Paper, Community Perspective". METABOLOMICS, 12(9). doi:10.1007/s11306-016-1094-6DOI: 10.1007/s11306-016-1094-6
Carbohydrate and fatty acid perturbations in the amniotic fluid of the recipient twin of pregnancies complicated by twin-twin transfusion syndrome in relation to treatment and fetal cardiovascular risk (Journal article)
Dunn, W. B., Allwood, J. W., Van Mieghem, T., Morris, R. K., Mackie, F. L., Fox, C. E., & Kilby, M. D. (2016). Carbohydrate and fatty acid perturbations in the amniotic fluid of the recipient twin of pregnancies complicated by twin-twin transfusion syndrome in relation to treatment and fetal cardiovascular risk. PLACENTA, 44, 6-12. doi:10.1016/j.placenta.2016.05.012DOI: 10.1016/j.placenta.2016.05.012
Characterisation of the metabolome of ocular tissues and post-mortem changes in the rat retina (Journal article)
Tan, S. Z., Mullard, G., Hollywood, K. A., Dunn, W. B., & Bishop, P. N. (2016). Characterisation of the metabolome of ocular tissues and post-mortem changes in the rat retina. EXPERIMENTAL EYE RESEARCH, 149, 8-15. doi:10.1016/j.exer.2016.05.019DOI: 10.1016/j.exer.2016.05.019
Metabolites involved in glycolysis and amino acid metabolism are altered in short children born small for gestational age (Journal article)
Murray, P. G., Butcher, I., Dunn, W. B., Stevens, A., Perchard, R., Hanson, D., . . . Clayton, P. E. (2016). Metabolites involved in glycolysis and amino acid metabolism are altered in short children born small for gestational age. PEDIATRIC RESEARCH, 80(2), 299-305. doi:10.1038/pr.2016.72DOI: 10.1038/pr.2016.72
Non-targeted UHPLC-MS metabolomic data processing methods: a comparative investigation of normalisation, missing value imputation, transformation and scaling (Journal article)
Di Guida, R., Engel, J., Allwood, J. W., Weber, R. J. M., Jones, M. R., Sommer, U., . . . Dunn, W. B. (2016). Non-targeted UHPLC-MS metabolomic data processing methods: a comparative investigation of normalisation, missing value imputation, transformation and scaling. METABOLOMICS, 12(5). doi:10.1007/s11306-016-1030-9DOI: 10.1007/s11306-016-1030-9
Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man (Journal article)
Hazlehurst, J. M., Oprescu, A. I., Nikolaou, N., Di Guida, R., Grinbergs, A. E. K., Davies, N. P., . . . Tomlinson, J. W. (2016). Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 101(1), 102-112. doi:10.1210/jc.2015-2928DOI: 10.1210/jc.2015-2928
Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy (Journal article)
Freeman, O. J., Unwin, R. D., Dowsey, A. W., Begley, P., Ali, S., Hollywood, K. A., . . . Gardiner, N. J. (2016). Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy. DIABETES, 65(1), 228-238. doi:10.2337/db15-0835DOI: 10.2337/db15-0835
Metabolomics reveals the physiological response of <i>Pseudomonas</i> <i>putida</i> KT2440 (UWC1) after pharmaceutical exposure (Journal article)
Currie, F., Broadhurst, D. I., Dunn, W. B., Sellick, C. A., & Goodacre, R. (2016). Metabolomics reveals the physiological response of <i>Pseudomonas</i> <i>putida</i> KT2440 (UWC1) after pharmaceutical exposure. MOLECULAR BIOSYSTEMS, 12(4), 1367-1377. doi:10.1039/c5mb00889aDOI: 10.1039/c5mb00889a
2015
Identification and Annotation of Lipid Species in Metabolomics Studies Need Improvement Reply (Journal article)
Dunn, W. B., & Boeing, H. (2015). Identification and Annotation of Lipid Species in Metabolomics Studies Need Improvement Reply. CLINICAL CHEMISTRY, 61(12), 1544-1546. doi:10.1373/clinchem.2015.246843DOI: 10.1373/clinchem.2015.246843
Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells (Journal article)
Armitage, E. G., Kotze, H. L., Allwood, J. W., Dunn, W. B., Goodacre, R., & Williams, K. J. (2015). Metabolic profiling reveals potential metabolic markers associated with Hypoxia Inducible Factor-mediated signalling in hypoxic cancer cells. SCIENTIFIC REPORTS, 5. doi:10.1038/srep15649DOI: 10.1038/srep15649
Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma (Journal article)
Ludwig, C., Williams, D. S., Bartlett, D. B., Essex, S. J., McNee, G., Allwood, J. W., . . . Tennant, D. A. (2015). Alterations in bone marrow metabolism are an early and consistent feature during the development of MGUS and multiple myeloma. BLOOD CANCER JOURNAL, 5. doi:10.1038/bcj.2015.85DOI: 10.1038/bcj.2015.85
A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications (Journal article)
Mullard, G., Allwood, J. W., Weber, R., Brown, M., Begley, P., Hollywood, K. A., . . . Dunn, W. B. (2015). A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications. METABOLOMICS, 11(5), 1068-1080. doi:10.1007/s11306-014-0763-6DOI: 10.1007/s11306-014-0763-6
A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications (vol 11, pg 1068, 2015) (Journal article)
Mullard, G., Allwood, J. W., Weber, R. J. M., Brown, M., Begley, P., Hollywood, K. A., . . . Dunn, W. B. (2015). A new strategy for MS/MS data acquisition applying multiple data dependent experiments on Orbitrap mass spectrometers in non-targeted metabolomic applications (vol 11, pg 1068, 2015). METABOLOMICS, 11(5), 1081. doi:10.1007/s11306-015-0771-1DOI: 10.1007/s11306-015-0771-1
Training needs in metabolomics (Journal article)
Weber, R. J. M., Winder, C. L., Larcombe, L. D., Dunn, W. B., & Viant, M. R. (2015). Training needs in metabolomics. METABOLOMICS, 11(4), 784-786. doi:10.1007/s11306-015-0815-6DOI: 10.1007/s11306-015-0815-6
Antiphospholipid Antibodies Alter Cell-Death-Regulating Lipid Metabolites in First and Third Trimester Human Placentae (Journal article)
Pantham, P., Heazell, A. E. P., Mullard, G., Begley, P., Chen, Q., Brown, M., . . . Chamley, L. W. (2015). Antiphospholipid Antibodies Alter Cell-Death-Regulating Lipid Metabolites in First and Third Trimester Human Placentae. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 74(2), 181-199. doi:10.1111/aji.12387DOI: 10.1111/aji.12387
Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells (Journal article)
Hollywood, K. A., Winder, C. L., Dunn, W. B., Xu, Y., Broadhurst, D., Griffiths, C. E. M., & Goodacre, R. (2015). Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells. MOLECULAR BIOSYSTEMS, 11(8), 2198-2209. doi:10.1039/c4mb00739eDOI: 10.1039/c4mb00739e
MUSCLE: automated multi-objective evolutionary optimization of targeted LC-MS/MS analysis (Journal article)
Bradbury, J., Genta-Jouve, G., Allwood, J. W., Dunn, W. B., Goodacre, R., Knowles, J. D., . . . Viant, M. R. (2015). MUSCLE: automated multi-objective evolutionary optimization of targeted LC-MS/MS analysis. BIOINFORMATICS, 31(6), 975-977. doi:10.1093/bioinformatics/btu740DOI: 10.1093/bioinformatics/btu740
Untargeted Metabolic Profiling Identifies Altered Serum Metabolites of Type 2 Diabetes Mellitus in a Prospective, Nested Case Control Study (Journal article)
Drogan, D., Dunn, W. B., Lin, W., Buijsse, B., Schulze, M. B., Langenberg, C., . . . Boeing, H. (2015). Untargeted Metabolic Profiling Identifies Altered Serum Metabolites of Type 2 Diabetes Mellitus in a Prospective, Nested Case Control Study. CLINICAL CHEMISTRY, 61(3), 487-497. doi:10.1373/clinchem.2014.228965DOI: 10.1373/clinchem.2014.228965
Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy (Journal article)
Gehmlich, K., Dodd, M. S., Allwood, J. W., Kelly, M., Bellahcene, M., Lad, H. V., . . . Dunn, W. B. (2015). Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy. MOLECULAR BIOSYSTEMS, 11(2), 564-573. doi:10.1039/c4mb00594eDOI: 10.1039/c4mb00594e
Molecular phenotyping of a UK population: defining the human serum metabolome (Journal article)
Dunn, W. B., Lin, W., Broadhurst, D., Begley, P., Brown, M., Zelena, E., . . . Kell, D. B. (2015). Molecular phenotyping of a UK population: defining the human serum metabolome. METABOLOMICS, 11(1), 9-26. doi:10.1007/s11306-014-0707-1DOI: 10.1007/s11306-014-0707-1
Cryptococcal 3-Hydroxy Fatty Acids Protect Cells Against Amoebal Phagocytosis (Journal article)
Madu, U. L., Ogundeji, A. O., Mochochoko, B. M., Pohl, C. H., Albertyn, J., Swart, C. W., . . . Sebolai, O. M. (2015). Cryptococcal 3-Hydroxy Fatty Acids Protect Cells Against Amoebal Phagocytosis. FRONTIERS IN MICROBIOLOGY, 6. doi:10.3389/fmicb.2015.01351DOI: 10.3389/fmicb.2015.01351
Discovery-based Studies of Mammalian Metabolomes with the Application of Mass Spectrometry Platforms (Journal article)
Dunn, W. B., Winder, C. L., & Carroll, K. M. (2015). Discovery-based Studies of Mammalian Metabolomes with the Application of Mass Spectrometry Platforms. METABOLIC PROFILING: DISEASE AND XENOBIOTICS, 21, 162-198. Retrieved from https://www.webofscience.com/
Profiling of spatial metabolite distributions in wheat leaves under normal and nitrate limiting conditions (Journal article)
Allwood, J. W., Chandra, S., Xu, Y., Dunn, W. B., Correa, E., Hopkins, L., . . . Bowsher, C. G. (2015). Profiling of spatial metabolite distributions in wheat leaves under normal and nitrate limiting conditions. PHYTOCHEMISTRY, 115, 99-111. doi:10.1016/j.phytochem.2015.01.007DOI: 10.1016/j.phytochem.2015.01.007
2014
Metabolomics Society Board election 2014: introduction of the new officers and directors (Journal article)
Dunn, W. (2014). Metabolomics Society Board election 2014: introduction of the new officers and directors. Metabolomics, 10(6), 1045-1046. doi:10.1007/s11306-014-0736-9DOI: 10.1007/s11306-014-0736-9
Metabolite identification: are you sure? And how do your peers gauge your confidence? (Journal article)
Creek, D. J., Dunn, W. B., Fiehn, O., Griffin, J. L., Hall, R. D., Lei, Z., . . . Wolfender, J. -L. (2014). Metabolite identification: are you sure? And how do your peers gauge your confidence?. METABOLOMICS, 10(3), 350-353. doi:10.1007/s11306-014-0656-8DOI: 10.1007/s11306-014-0656-8
A metabolomics investigation into the effects of HIV protease inhibitors on HPV16 E6 expressing cervical carcinoma cells (Journal article)
Kim, D. -H., Allwood, J. W., Moore, R. E., Marsden-Edwards, E., Dunn, W. B., Xu, Y., . . . Goodacre, R. (2014). A metabolomics investigation into the effects of HIV protease inhibitors on HPV16 E6 expressing cervical carcinoma cells. MOLECULAR BIOSYSTEMS, 10(3), 398-411. doi:10.1039/c3mb70423hDOI: 10.1039/c3mb70423h
HAMMER: automated operation of mass frontier to construct <i>in silico</i> mass spectral fragmentation libraries (Journal article)
Zhou, J., Weber, R. J. M., Allwood, J. W., Mistrik, R., Zhu, Z., Ji, Z., . . . Viant, M. R. (2014). HAMMER: automated operation of mass frontier to construct <i>in silico</i> mass spectral fragmentation libraries. BIOINFORMATICS, 30(4), 581-583. doi:10.1093/bioinformatics/btt711DOI: 10.1093/bioinformatics/btt711
Evidence That Multiple Defects in Lipid Regulation Occur before Hyperglycemia during the Prodrome of Type-2 Diabetes (Journal article)
Anderson, S. G., Dunn, W. B., Banerjee, M., Brown, M., Broadhurst, D. I., Goodacre, R., . . . Cruickshank, J. K. (2014). Evidence That Multiple Defects in Lipid Regulation Occur before Hyperglycemia during the Prodrome of Type-2 Diabetes. PLOS ONE, 9(9). doi:10.1371/journal.pone.0103217DOI: 10.1371/journal.pone.0103217
Yeast cells with impaired drug resistance accumulate glycerol and glucose (Journal article)
Dikicioglu, D., Oc, S., Rash, B. M., Dunn, W. B., Pir, P., Kell, D. B., . . . Oliver, S. G. (2014). Yeast cells with impaired drug resistance accumulate glycerol and glucose. MOLECULAR BIOSYSTEMS, 10(1), 93-102. doi:10.1039/c2mb25512jDOI: 10.1039/c2mb25512j
2013
A novel untargeted metabolomics correlation-based network analysis incorporating human metabolic reconstructions (Journal article)
Kotze, H. L., Armitage, E. G., Sharkey, K. J., Allwood, J. W., Dunn, W. B., Williams, K. J., & Goodacre, R. (2013). A novel untargeted metabolomics correlation-based network analysis incorporating human metabolic reconstructions. BMC SYSTEMS BIOLOGY, 7. doi:10.1186/1752-0509-7-107DOI: 10.1186/1752-0509-7-107
The role of reporting standards for metabolite annotation and identification in metabolomic studies (Journal article)
Salek, R. M., Steinbeck, C., Viant, M. R., Goodacre, R., & Dunn, W. B. (2013). The role of reporting standards for metabolite annotation and identification in metabolomic studies. GIGASCIENCE, 2. doi:10.1186/2047-217X-2-13DOI: 10.1186/2047-217X-2-13
A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes (Journal article)
Smallbone, K., Messiha, H. L., Carroll, K. M., Winder, C. L., Malys, N., Dunn, W. B., . . . Mendes, P. (2013). A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes. FEBS LETTERS, 587(17), 2832-2841. doi:10.1016/j.febslet.2013.06.043DOI: 10.1016/j.febslet.2013.06.043
Metabolomic analyses show that electron donor and acceptor ratios control anaerobic electron transfer pathways in <i>Shewanella oneidensis</i> (Journal article)
Wang, H., Correa, E., Dunn, W. B., Winder, C. L., Goodacre, R., & Lloyd, J. R. (2013). Metabolomic analyses show that electron donor and acceptor ratios control anaerobic electron transfer pathways in <i>Shewanella oneidensis</i>. METABOLOMICS, 9(3), 642-656. doi:10.1007/s11306-012-0488-3DOI: 10.1007/s11306-012-0488-3
Autocrine amplification of integrin αIIbβ3 activation and platelet adhesive responses by deoxyribose-1-phosphate (Journal article)
Vara, D. S., Campanella, M., Canobbio, I., Dunn, W. B., Pizzorno, G., Hirano, M., & Pula, G. (2013). Autocrine amplification of integrin αIIbβ3 activation and platelet adhesive responses by deoxyribose-1-phosphate. THROMBOSIS AND HAEMOSTASIS, 109(6), 1108-1119. doi:10.1160/TH12-10-0751DOI: 10.1160/TH12-10-0751
Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics (Journal article)
Dunn, W. B., Erban, A., Weber, R. J. M., Creek, D. J., Brown, M., Breitling, R., . . . Viant, M. R. (2013). Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics. METABOLOMICS, 9(1), S44-S66. doi:10.1007/s11306-012-0434-4DOI: 10.1007/s11306-012-0434-4
Mass spectrometry and metabolomics: past, present and future (Journal article)
Dunn, W. B., & Hankemeier, T. (2013). Mass spectrometry and metabolomics: past, present and future. METABOLOMICS, 9(1), S1-S3. doi:10.1007/s11306-013-0507-zDOI: 10.1007/s11306-013-0507-z
Diabetes - the Role of Metabolomics in the Discovery of New Mechanisms and Novel Biomarkers (Journal article)
Dunn, W. B. (2013). Diabetes - the Role of Metabolomics in the Discovery of New Mechanisms and Novel Biomarkers. Current Cardiovascular Risk Reports, 7(1), 25-32. doi:10.1007/s12170-012-0282-9DOI: 10.1007/s12170-012-0282-9
Metabolomics and Its Role in the Study of Mammalian Systems (Chapter)
Dunn, W. B., Mamas, M., & Heazell, A. (2013). Metabolomics and Its Role in the Study of Mammalian Systems. In Unknown Book (pp. 345-377). Wiley. doi:10.1002/9783527655861.ch14DOI: 10.1002/9783527655861.ch14
Biological Methods for Metabolic Research (Chapter)
Cebrián, A., Menchén, L., Sánchez-López, E., Casado-Vela, J., Díaz-Moralli, S., Cascante, M., . . . Lacal, J. C. (2013). Biological Methods for Metabolic Research. In Methodologies for Metabolomics (pp. 54-76). Cambridge University Press. doi:10.1017/cbo9780511996634.004DOI: 10.1017/cbo9780511996634.004
A community-driven global reconstruction of human metabolism (Journal article)
Thiele, I., Swainston, N., Fleming, R. M. T., Hoppe, A., Sahoo, S., Aurich, M. K., . . . Palsson, B. O. (2013). A community-driven global reconstruction of human metabolism. NATURE BIOTECHNOLOGY, 31(5), 419-+. doi:10.1038/nbt.2488DOI: 10.1038/nbt.2488
CASMI—The Small Molecule Identification Process from a Birmingham Perspective (Journal article)
Allwood, J., Weber, R., Zhou, J., He, S., Viant, M., & Dunn, W. (n.d.). CASMI—The Small Molecule Identification Process from a Birmingham Perspective. Metabolites, 3(2), 397-411. doi:10.3390/metabo3020397DOI: 10.3390/metabo3020397
2012
Liquid Chromatography-Mass Spectrometry Calibration Transfer and Metabolomics Data Fusion (Journal article)
Vaughan, A. A., Dunn, W. B., Allwood, J. W., Wedge, D. C., Blackhall, F. H., Whetton, A. D., . . . Goodacre, R. (2012). Liquid Chromatography-Mass Spectrometry Calibration Transfer and Metabolomics Data Fusion. ANALYTICAL CHEMISTRY, 84(22), 9848-9857. doi:10.1021/ac302227cDOI: 10.1021/ac302227c
Fingerprinting food: current technologies for the detection of food adulteration and contamination (Journal article)
Ellis, D. I., Brewster, V. L., Dunn, W. B., Allwood, J. W., Golovanov, A. P., & Goodacre, R. (2012). Fingerprinting food: current technologies for the detection of food adulteration and contamination. CHEMICAL SOCIETY REVIEWS, 41(17), 5706-5727. doi:10.1039/c2cs35138bDOI: 10.1039/c2cs35138b
Dupuytren's disease metabolite analyses reveals alterations following initial short-term fibroblast culturing (Journal article)
Rehman, S., Xu, Y., Dunn, W. B., Day, P. J. R., Westerhoff, H. V., Goodacre, R., & Bayat, A. (2012). Dupuytren's disease metabolite analyses reveals alterations following initial short-term fibroblast culturing. MOLECULAR BIOSYSTEMS, 8(9), 2274-2288. doi:10.1039/c2mb25173fDOI: 10.1039/c2mb25173f
The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans (Journal article)
Dunn, W. B., Wilson, I. D., Nicholls, A. W., & Broadhurst, D. (2012). The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans. BIOANALYSIS, 4(18), 2249-2264. doi:10.4155/BIO.12.204DOI: 10.4155/BIO.12.204
A Metabolomic Approach Identifies Differences in Maternal Serum in Third Trimester Pregnancies That End in Poor Perinatal Outcome (Journal article)
Heazell, A. E. P., Bernatavicius, G., Warrander, L., Brown, M. C., & Dunn, W. B. (2012). A Metabolomic Approach Identifies Differences in Maternal Serum in Third Trimester Pregnancies That End in Poor Perinatal Outcome. REPRODUCTIVE SCIENCES, 19(8), 863-875. doi:10.1177/1933719112438446DOI: 10.1177/1933719112438446
The metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy (Journal article)
Dunn, W. B., Brown, M., Worton, S. A., Davies, K., Jones, R. L., Kell, D. B., & Heazell, A. E. P. (2012). The metabolome of human placental tissue: investigation of first trimester tissue and changes related to preeclampsia in late pregnancy. METABOLOMICS, 8(4), 579-597. doi:10.1007/s11306-011-0348-6DOI: 10.1007/s11306-011-0348-6
Improving metabolic flux predictions using absolute gene expression data (Journal article)
Lee, D., Smallbone, K., Dunn, W. B., Murabito, E., Winder, C. L., Kell, D. B., . . . Swainston, N. (2012). Improving metabolic flux predictions using absolute gene expression data. BMC SYSTEMS BIOLOGY, 6. doi:10.1186/1752-0509-6-73DOI: 10.1186/1752-0509-6-73
Proof-of-principle study to detect metabolic changes in peritoneal dialysis effluent in patients who develop encapsulating peritoneal sclerosis (Journal article)
Dunn, W. B., Summers, A., Brown, M., Goodacre, R., Lambie, M., Johnson, T., . . . Brenchley, P. (2012). Proof-of-principle study to detect metabolic changes in peritoneal dialysis effluent in patients who develop encapsulating peritoneal sclerosis. NEPHROLOGY DIALYSIS TRANSPLANTATION, 27(6), 2502-2510. doi:10.1093/ndt/gfr662DOI: 10.1093/ndt/gfr662
Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment (Journal article)
Dikicioglu, D., Dunn, W. B., Kell, D. B., Kirdar, B., & Oliver, S. G. (2012). Short- and long-term dynamic responses of the metabolic network and gene expression in yeast to a transient change in the nutrient environment. MOLECULAR BIOSYSTEMS, 8(6), 1760-1774. doi:10.1039/c2mb05443dDOI: 10.1039/c2mb05443d
Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA) (Journal article)
Ugarte, M., Brown, M., Hollywood, K. A., Cooper, G. J., Bishop, P. N., & Dunn, W. B. (2012). Metabolomic analysis of rat serum in streptozotocin-induced diabetes and after treatment with oral triethylenetetramine (TETA). GENOME MEDICINE, 4. doi:10.1186/gm334DOI: 10.1186/gm334
Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets (vol 27, pg 1108, 2011) (Journal article)
Brown, M., Wedge, D. C., Goodacre, R., Kell, D. B., Baker, P. N., Kenny, L. C., . . . Dunn, W. B. (2012). Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets (vol 27, pg 1108, 2011). BIOINFORMATICS, 28(1), 149. doi:10.1093/bioinformatics/btr601DOI: 10.1093/bioinformatics/btr601
2011
Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy (Journal article)
Dunn, W. B., Broadhurst, D. I., Atherton, H. J., Goodacre, R., & Griffin, J. L. (2011). Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy. CHEMICAL SOCIETY REVIEWS, 40(1), 387-426. doi:10.1039/b906712bDOI: 10.1039/b906712b
Absolute Quantification of the Glycolytic Pathway in Yeast: DEPLOYMENT OF A COMPLETE QconCAT APPROACH (Journal article)
Carroll, K. M., Simpson, D. M., Eyers, C. E., Knight, C. G., Brownridge, P., Dunn, W. B., . . . Beynon, R. J. (2011). Absolute Quantification of the Glycolytic Pathway in Yeast: DEPLOYMENT OF A COMPLETE QconCAT APPROACH. MOLECULAR & CELLULAR PROTEOMICS, 10(12). doi:10.1074/mcp.M111.007633DOI: 10.1074/mcp.M111.007633
Integration of metabolomics in heart disease and diabetes research: current achievements and future outlook (Journal article)
Dunn, W. B., Goodacre, R., Neyses, L., & Mamas, M. (2011). Integration of metabolomics in heart disease and diabetes research: current achievements and future outlook. BIOANALYSIS, 3(19), 2205-2222. doi:10.4155/BIO.11.223DOI: 10.4155/BIO.11.223
Is Serum or Plasma More Appropriate for Intersubject Comparisons in Metabolomic Studies? An Assessment in Patients with Small-Cell Lung Cancer (Journal article)
Wedge, D. C., Allwood, J. W., Dunn, W., Vaughan, A. A., Simpson, K., Brown, M., . . . Goodacre, R. (2011). Is Serum or Plasma More Appropriate for Intersubject Comparisons in Metabolomic Studies? An Assessment in Patients with Small-Cell Lung Cancer. ANALYTICAL CHEMISTRY, 83(17), 6689-6697. doi:10.1021/ac2012224DOI: 10.1021/ac2012224
Metabolomic approaches reveal that cell wall modifications play a major role in ethylene-mediated resistance against <i>Botrytis cinerea</i> (Journal article)
Lloyd, A. J., Allwood, J. W., Winder, C. L., Dunn, W. B., Heald, J. K., Cristescu, S. M., . . . Mur, L. A. J. (2011). Metabolomic approaches reveal that cell wall modifications play a major role in ethylene-mediated resistance against <i>Botrytis cinerea</i>. PLANT JOURNAL, 67(5), 852-868. doi:10.1111/j.1365-313X.2011.04639.xDOI: 10.1111/j.1365-313X.2011.04639.x
Metabolic Profiling Uncovers a Phenotypic Signature of Small for Gestational Age in Early Pregnancy (Journal article)
Horgan, R. P., Broadhurst, D. I., Walsh, S. K., Dunn, W. B., Brown, M., Roberts, C. T., . . . Kenny, L. C. (2011). Metabolic Profiling Uncovers a Phenotypic Signature of Small for Gestational Age in Early Pregnancy. JOURNAL OF PROTEOME RESEARCH, 10(8), 3660-3673. doi:10.1021/pr2002897DOI: 10.1021/pr2002897
TARDIS-based microbial metabolomics: time and relative differences in systems (Journal article)
Winder, C. L., Dunn, W. B., & Goodacre, R. (2011). TARDIS-based microbial metabolomics: time and relative differences in systems. TRENDS IN MICROBIOLOGY, 19(7), 315-322. doi:10.1016/j.tim.2011.05.004DOI: 10.1016/j.tim.2011.05.004
Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry (Journal article)
Dunn, W. B., Broadhurst, D., Begley, P., Zelena, E., Francis-McIntyre, S., Anderson, N., . . . Goodacre, R. (2011). Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. NATURE PROTOCOLS, 6(7), 1060-1083. doi:10.1038/nprot.2011.335DOI: 10.1038/nprot.2011.335
Extensive metabolic cross-talk in melon fruit revealed by spatial and developmental combinatorial metabolomics (Journal article)
Moing, A., Aharoni, A., Biais, B., Rogachev, I., Meir, S., Brodsky, L., . . . Hall, R. D. (2011). Extensive metabolic cross-talk in melon fruit revealed by spatial and developmental combinatorial metabolomics. NEW PHYTOLOGIST, 190(3), 683-696. doi:10.1111/j.1469-8137.2010.03626.xDOI: 10.1111/j.1469-8137.2010.03626.x
ATR (ataxia telangiectasia mutated- and Rad3-related kinase) is activated by mild hypothermia in mammalian cells and subsequently activates p53 (Journal article)
Roobol, A., Roobol, J., Carden, M. J., Bastide, A., Willis, A. E., Dunn, W. B., . . . Smales, C. M. (2011). ATR (ataxia telangiectasia mutated- and Rad3-related kinase) is activated by mild hypothermia in mammalian cells and subsequently activates p53. BIOCHEMICAL JOURNAL, 435, 499-508. doi:10.1042/BJ20101303DOI: 10.1042/BJ20101303
Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets (Journal article)
Brown, M., Wedge, D. C., Goodacre, R., Kell, D. B., Baker, P. N., Kenny, L. C., . . . Dunn, W. B. (2011). Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets. BIOINFORMATICS, 27(8), 1108-1112. doi:10.1093/bioinformatics/btr079DOI: 10.1093/bioinformatics/btr079
Review: The effects of oxygen on normal and pre-eclamptic placental tissue - insights from metabolomics (Journal article)
Heazell, A. E. P., Brown, M., Worton, S. A., & Dunn, W. B. (2011). Review: The effects of oxygen on normal and pre-eclamptic placental tissue - insights from metabolomics. PLACENTA, 32, S119-S124. doi:10.1016/j.placenta.2010.12.001DOI: 10.1016/j.placenta.2010.12.001
Metabolic profiling of meat: assessment of pork hygiene and contamination with <i>Salmonella typhimurium</i> (Journal article)
Xu, Y., Cheung, W., Winder, C. L., Dunn, W. B., & Goodacre, R. (2011). Metabolic profiling of meat: assessment of pork hygiene and contamination with <i>Salmonella typhimurium</i>. ANALYST, 136(3), 508-514. doi:10.1039/c0an00394hDOI: 10.1039/c0an00394h
Adapting <i>in vitro</i> dual perfusion of the human placenta to soluble oxygen tensions associated with normal and pre-eclamptic pregnancy (Journal article)
Soydemir, F., Kuruvilla, S., Brown, M., Dunn, W., Day, P., Crocker, I. P., . . . Brownbill, P. (2011). Adapting <i>in vitro</i> dual perfusion of the human placenta to soluble oxygen tensions associated with normal and pre-eclamptic pregnancy. LABORATORY INVESTIGATION, 91(2), 181-189. doi:10.1038/labinvest.2010.171DOI: 10.1038/labinvest.2010.171
Fit-for-Purpose Quenching and Extraction Protocols for Metabolic Profiling of Yeast Using Chromatography-Mass Spectrometry Platforms (Chapter)
Winder, C. L., & Dunn, W. B. (2011). Fit-for-Purpose Quenching and Extraction Protocols for Metabolic Profiling of Yeast Using Chromatography-Mass Spectrometry Platforms. In YEAST SYSTEMS BIOLOGY: METHODS AND PROTOCOLS (Vol. 759, pp. 225-238). doi:10.1007/978-1-61779-173-4_14DOI: 10.1007/978-1-61779-173-4_14
MASS SPECTROMETRY IN SYSTEMS BIOLOGY: AN INTRODUCTION (Chapter)
Dunn, W. B. (2011). MASS SPECTROMETRY IN SYSTEMS BIOLOGY: AN INTRODUCTION. In METHODS IN ENZYMOLOGY, VOL 500 (Vol. 500, pp. 15-35). doi:10.1016/B978-0-12-385118-5.00002-5DOI: 10.1016/B978-0-12-385118-5.00002-5
Mass Spectrometry in Systems Biology (Chapter)
Dunn, W. B. (2011). Mass Spectrometry in Systems Biology. In Methods in Enzymology (pp. 15-35). Elsevier. doi:10.1016/b978-0-12-385118-5.00002-5DOI: 10.1016/b978-0-12-385118-5.00002-5
SAMPLE PREPARATION RELATED TO THE INTRACELLULAR METABOLOME OF YEAST: METHODS FOR QUENCHING, EXTRACTION, AND METABOLITE QUANTITATION (Chapter)
Dunn, W. B., & Winder, C. L. (2011). SAMPLE PREPARATION RELATED TO THE INTRACELLULAR METABOLOME OF YEAST: METHODS FOR QUENCHING, EXTRACTION, AND METABOLITE QUANTITATION. In METHODS IN ENZYMOLOGY, VOL 500 (Vol. 500, pp. 277-297). doi:10.1016/B978-0-12-385118-5.00015-3DOI: 10.1016/B978-0-12-385118-5.00015-3
Sample Preparation Related to the Intracellular Metabolome of Yeast (Chapter)
Dunn, W. B., & Winder, C. L. (2011). Sample Preparation Related to the Intracellular Metabolome of Yeast. In Methods in Enzymology (pp. 277-297). Elsevier. doi:10.1016/b978-0-12-385118-5.00015-3DOI: 10.1016/b978-0-12-385118-5.00015-3
The role of metabolites and metabolomics in clinically applicable biomarkers of disease (Journal article)
Mamas, M., Dunn, W. B., Neyses, L., & Goodacre, R. (2011). The role of metabolites and metabolomics in clinically applicable biomarkers of disease. ARCHIVES OF TOXICOLOGY, 85(1), 5-17. doi:10.1007/s00204-010-0609-6DOI: 10.1007/s00204-010-0609-6
2010
Paracrine Stimulation of Endothelial Cell Motility and Angiogenesis by Platelet-Derived Deoxyribose-1-Phosphate (Journal article)
Pula, G., Garonna, E., Dunn, W. B., Hirano, M., Pizzorno, G., Campanella, M., . . . Wheeler-Jones, C. P. D. (2010). Paracrine Stimulation of Endothelial Cell Motility and Angiogenesis by Platelet-Derived Deoxyribose-1-Phosphate. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 30(12), 2631-U566. doi:10.1161/ATVBAHA.110.215855DOI: 10.1161/ATVBAHA.110.215855
Systematic integration of experimental data and models in systems biology (Journal article)
Li, P., Dada, J. O., Jameson, D., Spasic, I., Swainston, N., Carroll, K., . . . Paton, N. W. (2010). Systematic integration of experimental data and models in systems biology. BMC BIOINFORMATICS, 11. doi:10.1186/1471-2105-11-582DOI: 10.1186/1471-2105-11-582
Further developments towards a genome-scale metabolic model of yeast (Journal article)
Dobson, P. D., Smallbone, K., Jameson, D., Simeonidis, E., Lanthaler, K., Pir, P., . . . Mendes, P. (2010). Further developments towards a genome-scale metabolic model of yeast. BMC SYSTEMS BIOLOGY, 4. doi:10.1186/1752-0509-4-145DOI: 10.1186/1752-0509-4-145
Changes in the Metabolic Footprint of Placental Explant-Conditioned Medium Cultured in Different Oxygen Tensions from Placentas of Small for Gestational Age and Normal Pregnancies (Journal article)
Horgan, R. P., Broadhurst, D. I., Dunn, W. B., Brown, M., Heazell, A. E. P., Kell, D. B., . . . Kenny, L. C. (2010). Changes in the Metabolic Footprint of Placental Explant-Conditioned Medium Cultured in Different Oxygen Tensions from Placentas of Small for Gestational Age and Normal Pregnancies. PLACENTA, 31(10), 893-901. doi:10.1016/j.placenta.2010.07.002DOI: 10.1016/j.placenta.2010.07.002
Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers (Journal article)
Kenny, L. C., Broadhurst, D. I., Dunn, W., Brown, M., North, R. A., McCowan, L., . . . Baker, P. N. (2010). Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers. HYPERTENSION, 56(4), 741-749. doi:10.1161/HYPERTENSIONAHA.110.157297DOI: 10.1161/HYPERTENSIONAHA.110.157297
Assessment of adaptive focused acoustics <i>versus</i> manual vortex/freeze-thaw for intracellular metabolite extraction from <i>Streptomyces lividans</i> producing recombinant proteins using GC-MS and multi-block principal component analysis (Journal article)
Kassama, Y., Xu, Y., Dunn, W. B., Geukens, N., Anne, J., & Goodacre, R. (2010). Assessment of adaptive focused acoustics <i>versus</i> manual vortex/freeze-thaw for intracellular metabolite extraction from <i>Streptomyces lividans</i> producing recombinant proteins using GC-MS and multi-block principal component analysis. ANALYST, 135(5), 934-942. doi:10.1039/b918163fDOI: 10.1039/b918163f
Metabolite Identification in Metabolomics (Journal article)
Dunn, W. (2010). Metabolite Identification in Metabolomics. GENETIC ENGINEERING & BIOTECHNOLOGY NEWS, 30(8), 36-37. Retrieved from https://www.webofscience.com/
2009
Systems Biology: The elements and principles of Life (Journal article)
Westerhoff, H. V., Winder, C., Messiha, H., Simeonidis, E., Adamczyk, M., Verma, M., . . . Dunn, W. (2009). Systems Biology: The elements and principles of Life. FEBS LETTERS, 583(24), 3882-3890. doi:10.1016/j.febslet.2009.11.018DOI: 10.1016/j.febslet.2009.11.018
Inter-laboratory reproducibility of fast gas chromatography-electron impact-time of flight mass spectrometry (GC-EI-TOF/MS) based plant metabolomics (Journal article)
Allwood, J. W., Erban, A., de Koning, S., Dunn, W. B., Luedemann, A., Lommen, A., . . . Goodacre, R. (2009). Inter-laboratory reproducibility of fast gas chromatography-electron impact-time of flight mass spectrometry (GC-EI-TOF/MS) based plant metabolomics. METABOLOMICS, 5(4), 479-496. doi:10.1007/s11306-009-0169-zDOI: 10.1007/s11306-009-0169-z
Changes in the Metabolic Footprint of Placental Explant-Conditioned Culture Medium Identifies Metabolic Disturbances Related to Hypoxia and Pre-Eclampsia (Journal article)
Dunn, W. B., Brown, M., Worton, S. A., Crocker, I. P., Broadhurst, D., Horgan, R., . . . Heazell, A. E. P. (2009). Changes in the Metabolic Footprint of Placental Explant-Conditioned Culture Medium Identifies Metabolic Disturbances Related to Hypoxia and Pre-Eclampsia. PLACENTA, 30(11), 974-980. doi:10.1016/j.placenta.2009.08.008DOI: 10.1016/j.placenta.2009.08.008
Development and Performance of a Gas Chromatography-Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum (Journal article)
Begley, P., Francis-McIntyre, S., Dunn, W. B., Broadhurst, D. I., Halsall, A., Tseng, A., . . . Kell, D. B. (2009). Development and Performance of a Gas Chromatography-Time-of-Flight Mass Spectrometry Analysis for Large-Scale Nontargeted Metabolomic Studies of Human Serum. ANALYTICAL CHEMISTRY, 81(16), 7038-7046. doi:10.1021/ac9011599DOI: 10.1021/ac9011599
Biomarkers of Dietary Energy Restriction in Women at Increased Risk of Breast Cancer (Journal article)
Ong, K. R., Sims, A. H., Harvie, M., Chapman, M., Dunn, W. B., Broadhurst, D., . . . Howell, A. (2009). Biomarkers of Dietary Energy Restriction in Women at Increased Risk of Breast Cancer. CANCER PREVENTION RESEARCH, 2(8), 720-731. doi:10.1158/1940-6207.CAPR-09-0008DOI: 10.1158/1940-6207.CAPR-09-0008
<SUP>1</SUP>H NMR, GC-EI-TOFMS, and Data Set Correlation for Fruit Metabolomics: Application to Spatial Metabolite Analysis in Melon (Journal article)
Biais, B., Allwood, J. W., Deborde, C., Xu, Y., Maucourt, M., Beauvoit, B., . . . Moing, A. (2009). <SUP>1</SUP>H NMR, GC-EI-TOFMS, and Data Set Correlation for Fruit Metabolomics: Application to Spatial Metabolite Analysis in Melon. ANALYTICAL CHEMISTRY, 81(8), 2884-2894. doi:10.1021/ac9001996DOI: 10.1021/ac9001996
Development of a Robust and Repeatable UPLC-MS Method for the Long-Term Metabolomic Study of Human Serum (Journal article)
Zelena, E., Dunn, W. B., Broadhurst, D., Francis-McIntyre, S., Carroll, K. M., Begley, P., . . . Kellt, D. B. (2009). Development of a Robust and Repeatable UPLC-MS Method for the Long-Term Metabolomic Study of Human Serum. ANALYTICAL CHEMISTRY, 81(4), 1357-1364. doi:10.1021/ac8019366DOI: 10.1021/ac8019366
Effective Quenching Processes for Physiologically Valid Metabolite Profiling of Suspension Cultured Mammalian Cells (Journal article)
Sellick, C. A., Hansen, R., Maqsood, A. R., Dunn, W. B., Stephens, G. M., Goodacre, R., & Dickson, A. J. (2009). Effective Quenching Processes for Physiologically Valid Metabolite Profiling of Suspension Cultured Mammalian Cells. ANALYTICAL CHEMISTRY, 81(1), 174-183. doi:10.1021/ac8016899DOI: 10.1021/ac8016899
Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics (Journal article)
Brown, M., Dunn, W. B., Dobson, P., Patel, Y., Winder, C. L., Francis-McIntyre, S., . . . Kell, D. B. (2009). Mass spectrometry tools and metabolite-specific databases for molecular identification in metabolomics. ANALYST, 134(7), 1322-1332. doi:10.1039/b901179jDOI: 10.1039/b901179j
2008
A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology (Journal article)
Herrgard, M. J., Swainston, N., Dobson, P., Dunn, W. B., Arga, K. Y., Arvas, M., . . . Kell, D. B. (2008). A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. NATURE BIOTECHNOLOGY, 26(10), 1155-1160. doi:10.1038/nbt1492DOI: 10.1038/nbt1492
Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system (Journal article)
Dunn, W. B., Broadhurst, D., Brown, M., Baker, P. N., Redman, C. W. G., Kenny, L. C., & Kell, D. B. (2008). Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 871(2), 288-298. doi:10.1016/j.jchromb.2008.03.021DOI: 10.1016/j.jchromb.2008.03.021
Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers (Journal article)
Heazell, A. E. P., Brown, M., Dunn, W. B., Worton, S. A., Crocker, I. P., Baker, P. N., & Kell, D. B. (2008). Analysis of the metabolic footprint and tissue metabolome of placental villous explants cultured at different oxygen tensions reveals novel redox biomarkers. PLACENTA, 29(8), 691-698. doi:10.1016/j.placenta.2008.05.002DOI: 10.1016/j.placenta.2008.05.002
Genomics in cardiac metabolism (Journal article)
Samuel, J. -L., Schaub, M. C., Zaugg, M., Mamas, M., Dunn, W. B., & Swynghedauw, B. (2008). Genomics in cardiac metabolism. CARDIOVASCULAR RESEARCH, 79(2), 218-227. doi:10.1093/cvr/cvn061DOI: 10.1093/cvr/cvn061
Detection and identification of novel metabolomic biomarkers in preeclampsia (Journal article)
Kenny, L. C., Broadhurst, D., Brown, M., Dunn, W. B., Redman, C. W. G., Kill, D. B., & Baker, P. N. (2008). Detection and identification of novel metabolomic biomarkers in preeclampsia. REPRODUCTIVE SCIENCES, 15(6), 591-597. doi:10.1177/1933719108316908DOI: 10.1177/1933719108316908
Relatedness of medically important strains of <i>Saccharomyces cerevisiae</i> as revealed by phylogenetics and metabolomics (Journal article)
MacKenzie, D. A., Defernez, M., Dunn, W. B., Brown, M., Fuller, L. J., Seco de Herrera, S. R. M., . . . Roberts, I. N. (2008). Relatedness of medically important strains of <i>Saccharomyces cerevisiae</i> as revealed by phylogenetics and metabolomics. YEAST, 25(7), 501-512. doi:10.1002/yea.1601DOI: 10.1002/yea.1601
Global metabolic profiling of <i>Escherichia coli</i> cultures:: An evaluation of methods for quenching and extraction of intracellular metabolites (Journal article)
Winder, C. L., Dunn, W. B., Schuler, S., Broadhurst, D., Jarvis, R., Stephens, G. M., & Goodacre, R. (2008). Global metabolic profiling of <i>Escherichia coli</i> cultures:: An evaluation of methods for quenching and extraction of intracellular metabolites. ANALYTICAL CHEMISTRY, 80(8), 2939-2948. doi:10.1021/ac7023409DOI: 10.1021/ac7023409
A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols (Journal article)
Dunn, W. B., Broadhurst, D., Ellis, D. I., Brown, M., Halsall, A., O'Hagan, S., . . . Kell, D. B. (2008). A GC-TOF-MS study of the stability of serum and urine metabolomes during the UK Biobank sample collection and preparation protocols. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 37, 23-30. doi:10.1093/ije/dym281DOI: 10.1093/ije/dym281
Comparative evaluation of software for deconvolution of metabolomics data based on GC-TOF-MS (Journal article)
Lu, H., Dunn, W. B., Shen, H., Kell, D. B., & Liang, Y. (2008). Comparative evaluation of software for deconvolution of metabolomics data based on GC-TOF-MS. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 27(3), 215-227. doi:10.1016/j.trac.2007.11.004DOI: 10.1016/j.trac.2007.11.004
Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, <i>Stereum hirsutum</i> with its competitors <i>Coprinus micaceus</i> and <i>Coprinus disseminatus</i> (Journal article)
Peiris, D., Dunn, W. B., Brown, M., Kell, D. B., Roy, I., & Hedger, J. N. (2008). Metabolite profiles of interacting mycelial fronts differ for pairings of the wood decay basidiomycete fungus, <i>Stereum hirsutum</i> with its competitors <i>Coprinus micaceus</i> and <i>Coprinus disseminatus</i>. METABOLOMICS, 4(1), 52-62. doi:10.1007/s11306-007-0100-4DOI: 10.1007/s11306-007-0100-4
Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes (Journal article)
Dunn, W. B. (2008). Current trends and future requirements for the mass spectrometric investigation of microbial, mammalian and plant metabolomes. PHYSICAL BIOLOGY, 5(1). doi:10.1088/1478-3975/5/1/011001DOI: 10.1088/1478-3975/5/1/011001
2007
Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate (Journal article)
Dunn, W. B., Broadhurst, D. I., Deepak, S. M., Buch, M. H., McDowell, G., Spasic, I., . . . Neyses, L. (2007). Serum metabolomics reveals many novel metabolic markers of heart failure, including pseudouridine and 2-oxoglutarate. METABOLOMICS, 3(4), 413-426. doi:10.1007/s11306-007-0063-5DOI: 10.1007/s11306-007-0063-5
Metabolic fingerprinting as a diagnostic tool (Journal article)
Ellis, D. I., Dunn, W. B., Griffin, J. L., Allwood, J. W., & Goodacre, R. (2007). Metabolic fingerprinting as a diagnostic tool. PHARMACOGENOMICS, 8(9), 1243-1266. doi:10.2217/14622416.8.9.1243DOI: 10.2217/14622416.8.9.1243
Metabolic footprinting as a tool for discriminating between brewing yeasts (Journal article)
Pope, G. A., MacKenzie, D. A., Defemez, M., Aroso, M. A. M. M., Fuller, L. J., Mellon, F. A., . . . Roberts, I. N. (2007). Metabolic footprinting as a tool for discriminating between brewing yeasts. YEAST, 24(8), 667-679. doi:10.1002/yea.1499DOI: 10.1002/yea.1499
Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., . . . Oliver, S. G. (2007). Growth control of the eukaryote cell: a systems biology study in yeast.. Journal of biology, 6(2), 4. doi:10.1186/jbiol54DOI: 10.1186/jbiol54
Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics (Journal article)
Hagan, S. O., Dunn, W. B., Knowles, J. D., Broadhurst, D., Williams, R., Ashworth, J. J., . . . Kell, D. B. (2007). Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics. ANALYTICAL CHEMISTRY, 79(2), 464-476. doi:10.1021/ac061443+DOI: 10.1021/ac061443+
2006
MeMo: a hybrid SQL/XML approach to metabolomic data management for functional genomics (Journal article)
Spasic, I., Dunn, W. B., Velarde, G., Tseng, A., Jenkins, H., Hardy, N., . . . Kell, D. B. (2006). MeMo: a hybrid SQL/XML approach to metabolomic data management for functional genomics. BMC BIOINFORMATICS, 7. doi:10.1186/1471-2105-7-281DOI: 10.1186/1471-2105-7-281
Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles (Journal article)
Underwood, B. R., Broadhurst, D., Dunn, W. B., Ellis, D. I., Michell, A. W., Vacher, C., . . . Rubinsztein, D. C. (2006). Huntington disease patients and transgenic mice have similar pro-catabolic serum metabolite profiles. BRAIN, 129, 877-886. doi:10.1093/brain/awl027DOI: 10.1093/brain/awl027
2005
A laser desorption ionisation mass spectrometry approach for high throughput metabolomics (Journal article)
Vaidyanathan, S., Jones, D., Broadhurst, D. I., Ellis, J., Jenkins, T., Dunn, W. B., . . . Goodacre, R. (2005). A laser desorption ionisation mass spectrometry approach for high throughput metabolomics. METABOLOMICS, 1(3), 243-250. doi:10.1007/s11306-005-0007-xDOI: 10.1007/s11306-005-0007-x
Metabolic footprinting and systems biology: the medium is the message. (Journal article)
Kell, D. B., Brown, M., Davey, H. M., Dunn, W. B., Spasic, I., & Oliver, S. G. (2005). Metabolic footprinting and systems biology: the medium is the message.. Nature reviews. Microbiology, 3(7), 557-565. doi:10.1038/nrmicro1177DOI: 10.1038/nrmicro1177
Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning (Journal article)
Kenny, L. C., Dunn, W. B., Ellis, D. I., Myers, J., Baker, P. N., & Kell, D. B. (2005). Novel biomarkers for pre-eclampsia detected using metabolomics and machine learning. METABOLOMICS, 1(3), 227-234. doi:10.1007/s11306-005-0003-1DOI: 10.1007/s11306-005-0003-1
Evaluation of automated electrospray-TOF mass spectrometryfor metabolic fingerprinting of the plant metabolome (Journal article)
Dunn, W. B., Overy, S., & Quick, W. P. (2005). Evaluation of automated electrospray-TOF mass spectrometryfor metabolic fingerprinting of the plant metabolome. METABOLOMICS, 1(2), 137-148. doi:10.1007/s11306-005-4433-6DOI: 10.1007/s11306-005-4433-6
A metabolome pipeline: from concept to data to knowledge (Journal article)
Brown, M., Dunn, W. B., Ellis, D. I., Goodacre, R., Handl, J., Knowles, J. D., . . . Kell, D. B. (2005). A metabolome pipeline: from concept to data to knowledge. METABOLOMICS, 1(1), 39-51. doi:10.1007/s11306-005-1106-4DOI: 10.1007/s11306-005-1106-4
Closed-loop, multiobjective optimization of analytical instrumentation: Gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations (Journal article)
O'Hagan, S., Dunn, W. B., Brown, M., Knowles, J. D., & Kell, D. B. (2005). Closed-loop, multiobjective optimization of analytical instrumentation: Gas chromatography/time-of-flight mass spectrometry of the metabolomes of human serum and of yeast fermentations. ANALYTICAL CHEMISTRY, 77(1), 290-303. doi:10.1021/ac049146xDOI: 10.1021/ac049146x
Measuring the metabolome: current analytical technologies (Journal article)
Dunn, W. B., Bailey, N. J. C., & Johnson, H. E. (2005). Measuring the metabolome: current analytical technologies. ANALYST, 130(5), 606-625. doi:10.1039/b418288jDOI: 10.1039/b418288j
Metabolic footprinting and systems biology: The medium is the message (Journal article)
Kell, D. B., Brown, M., Davey, H. M., Dunn, W. B., Spasic, I., & Oliver, S. G. (2005). Metabolic footprinting and systems biology: The medium is the message. NATURE REVIEWS MICROBIOLOGY, 3(7), 557-565. doi:10.1038/nrmicro1177DOI: 10.1038/nrmicro1177
Metabolomics: Current analytical platforms and methodologies (Journal article)
Dunn, W. B., & Ellis, D. I. (2005). Metabolomics: Current analytical platforms and methodologies. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 24(4), 285-294. doi:10.1016/j.trac.2004.11.021DOI: 10.1016/j.trac.2004.11.021
2004
Ellis, D. I., O'Hagan, S., Dunn, W. B., Brown, M., & Vaidyanathan, S. (2004). From genomes to systems.. Genome biology, 5(11), 354. doi:10.1186/gb-2004-5-11-354DOI: 10.1186/gb-2004-5-11-354
Metabolomics by numbers: acquiring and understanding global metabolite data (Journal article)
Goodacre, R., Vaidyanathan, S., Dunn, W. B., Harrigan, G. G., & Kell, D. B. (2004). Metabolomics by numbers: acquiring and understanding global metabolite data. TRENDS IN BIOTECHNOLOGY, 22(5), 245-252. doi:10.1016/j.tibtech.2004.03.007DOI: 10.1016/j.tibtech.2004.03.007
1996
Novel techniques for the off-line analysis of liquid process streams by mass spectrometry (Journal article)
Townshend, A., Green, J. D., & Dunn, W. B. (1996). Novel techniques for the off-line analysis of liquid process streams by mass spectrometry. ANALYST, 121(10), 1435-1441. doi:10.1039/an9962101435DOI: 10.1039/an9962101435
1995
THE POTENTIAL OF ONLINE HEADSPACE ANALYSIS OF LIQUID STREAMS USING DIRECT MASS-SPECTROMETRY DETECTION (Journal article)
TOWNSHEND, A., GREEN, J. D., & DUNN, W. B. (1995). THE POTENTIAL OF ONLINE HEADSPACE ANALYSIS OF LIQUID STREAMS USING DIRECT MASS-SPECTROMETRY DETECTION. ANALYTICAL PROCEEDINGS, 32(9), 361-363. doi:10.1039/ai9953200361DOI: 10.1039/ai9953200361
