Photo of Dr Urszula McClurg

Dr Urszula McClurg MSc, PhD

Tenure Track Research Fellow Molecular & Physiology Cell Signalling

    Publications

    2020

    Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability (Journal article)

    Prendergast, L., McClurg, U. L., Hristova, R., Berlinguer-Palmini, R., Greener, S., Veitch, K., . . . Papamichos-Chronakis, M. (2020). Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability. Nature Communications, 11. doi:10.1038/s41467-020-18306-x

    DOI: 10.1038/s41467-020-18306-x

    Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (vol 11, 646, 2020) (Journal article)

    Ndeh, D., Basle, A., Strahl, H., Yates, E. A., McClurgg, U. L., Henrissat, B., . . . Cartmell, A. (2020). Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (vol 11, 646, 2020). NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-18097-1

    DOI: 10.1038/s41467-020-18097-1

    Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (Journal article)

    Ndeh, D., Baslé, A., Strahl, H., Yates, E. A., McClurgg, U. L., Henrissat, B., . . . Cartmell, A. (2020). Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus. Nature Communications, 11. doi:10.1038/s41467-020-14509-4

    DOI: 10.1038/s41467-020-14509-4

    2019

    A pseudo-meiotic centrosomal function of TEX12 in cancer (Journal article)

    Sandhu, S., Salmon, L. J., Hunter, J. E., Wilson, C. L., Perkins, N. D., Hunter, N., . . . McClurg, U. L. (2019). A pseudo-meiotic centrosomal function of TEX12 in cancer. doi:10.1101/509869

    DOI: 10.1101/509869

    2018

    Ex vivo Culture and Lentiviral Transduction of Benign Prostatic Hyperplasia (BPH) Samples. (Journal article)

    McClurg, U. L., McCracken, S. R., Butler, L., Riabowol, K. T., & Binda, O. (2018). Ex vivo Culture and Lentiviral Transduction of Benign Prostatic Hyperplasia (BPH) Samples.. Bio-protocol, 8(21). doi:10.21769/bioprotoc.3075

    DOI: 10.21769/bioprotoc.3075

    The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival (Journal article)

    McClurg, U. L., Azizyan, M., Dransfield, D. T., Namdev, N., Chit, N. C. T. H., Nakjang, S., & Robson, C. N. (2018). The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival. Oncotarget, 9(38), 24992-25007. doi:10.18632/oncotarget.25167

    DOI: 10.18632/oncotarget.25167

    Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12 (Journal article)

    McClurg, U. L., Chit, N. C. T. H., Azizyan, M., Edwards, J., Nabbi, A., Riabowol, K. T., . . . Robson, C. N. (2018). Molecular mechanism of the TP53-MDM2-AR-AKT signalling network regulation by USP12. ONCOGENE, 37(34), 4679-4691. doi:10.1038/s41388-018-0283-3

    DOI: 10.1038/s41388-018-0283-3

    Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein (Journal article)

    McClurg, U. L., Nabbi, A., Ricordel, C., Korolchuk, S., McCracken, S., Heer, R., . . . Binda, O. (2018). Human ex vivo prostate tissue model system identifies ING3 as an oncoprotein. British Journal of Cancer, 118, 713-726. doi:10.1038/bjc.2017.447

    DOI: 10.1038/bjc.2017.447

    2017

    The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration (Journal article)

    Munkley, J., McClurg, U. L., Livermore, K. E., Ehrmann, I., Knight, B., Mccullagh, P., . . . Elliott, D. J. (2017). The cancer-associated cell migration protein TSPAN1 is under control of androgens and its upregulation increases prostate cancer cell migration. SCIENTIFIC REPORTS, 7. doi:10.1038/s41598-017-05489-5

    DOI: 10.1038/s41598-017-05489-5

    ING3 promotes prostate cancer growth by activating the androgen receptor (Journal article)

    Nabbi, A., McClurg, U. L., Thalappilly, S., Almami, A., Mobahat, M., Bismar, T. A., . . . Riabowol, K. T. (2017). ING3 promotes prostate cancer growth by activating the androgen receptor. BMC MEDICINE, 15. doi:10.1186/s12916-017-0854-0

    DOI: 10.1186/s12916-017-0854-0

    Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity (Journal article)

    McClurg, U. L., Cork, D. M. W., Darby, S., Ryan-Munden, C. A., Nakjang, S., Cortes, L. M., . . . Robson, C. N. (2017). Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity. NUCLEIC ACIDS RESEARCH, 45(04), 1793-1804. doi:10.1093/nar/gkw1162

    DOI: 10.1093/nar/gkw1162

    2016

    Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells (Journal article)

    Logan, I. R., McClurg, U. L., Jones, D. L., O'Neill, D. J., Shaheen, F. S., Lunec, J., . . . Robson, C. N. (2016). Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells. ONCOTARGET, 7(46), 74724-74733. doi:10.18632/oncotarget.12542

    DOI: 10.18632/oncotarget.12542

    Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3 (Journal article)

    Kim, S., Natesan, S., Cornilescu, G., Carlson, S., Tonelli, M., McClurg, U. L., . . . Glass, K. C. (2016). Mechanism of Histone H3K4me3 Recognition by the Plant Homeodomain of Inhibitor of Growth 3. JOURNAL OF BIOLOGICAL CHEMISTRY, 291(35), 18326-18341. doi:10.1074/jbc.M115.690651

    DOI: 10.1074/jbc.M115.690651

    2015

    Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer (Journal article)

    McClurg, U. L., Harle, V. J., Nabbi, A., Batalha-Pereira, A., Walker, S., Coffey, K., . . . Robson, C. N. (2015). Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer. ONCOTARGET, 6(35), 37724-37736. doi:10.18632/oncotarget.6075

    DOI: 10.18632/oncotarget.6075

    The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells. (Journal article)

    Munkley, J., Livermore, K. E., McClurg, U. L., Kalna, G., Knight, B., McCullagh, P., . . . Elliott, D. J. (2015). The PI3K regulatory subunit gene PIK3R1 is under direct control of androgens and repressed in prostate cancer cells.. Oncoscience, 2(9), 755-764. doi:10.18632/oncoscience.243

    DOI: 10.18632/oncoscience.243

    Deubiquitinating enzymes as oncotargets (Journal article)

    McClurg, U. L., & Robson, C. N. (2015). Deubiquitinating enzymes as oncotargets. ONCOTARGET, 6(12), 9657-9668. doi:10.18632/oncotarget.3922

    DOI: 10.18632/oncotarget.3922

    Epithelial cell ADAM17 activation by Helicobacter pylori: role of ADAM17 C-terminus and Threonine-735 phosphorylation (Journal article)

    McClurg, U. L., Danjo, K., King, H. O., Scott, G. B., Robinson, P. A., & Crabtree, J. E. (2015). Epithelial cell ADAM17 activation by Helicobacter pylori: role of ADAM17 C-terminus and Threonine-735 phosphorylation. MICROBES AND INFECTION, 17(3), 205-214. doi:10.1016/j.micinf.2014.11.011

    DOI: 10.1016/j.micinf.2014.11.011

    2014

    Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway (Journal article)

    McClurg, U. L., Summerscales, E. E., Harle, V. J., Gaughan, L., & Robson, C. N. (2014). Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway. ONCOTARGET, 5(16), 7081-7092. doi:10.18632/oncotarget.2162

    DOI: 10.18632/oncotarget.2162

    Literature Search and Review (Journal article)

    Davis, M. I., Lea, W., Simeonov, A., & Auld, D. (2014). Literature Search and Review. ASSAY and Drug Development Technologies, 12(2), 101-109. doi:10.1089/adt.2014.1202.lr

    DOI: 10.1089/adt.2014.1202.lr

    Two plasmid-encoded genes of enteropathogenic Escherichia coli strain K798 promote invasion and survival within HEp-2 cells (Journal article)

    Burska, U. L., & Fletcher, J. N. (2014). Two plasmid-encoded genes of enteropathogenic Escherichia coli strain K798 promote invasion and survival within HEp-2 cells. APMIS, 122(10), 922-930. doi:10.1111/apm.12234

    DOI: 10.1111/apm.12234

    2013

    Deubiquitinating Enzyme Usp12 Is a Novel Co-activator of the Androgen Receptor (Journal article)

    Burska, U. L., Harle, V. J., Coffey, K., Darby, S., Ramsey, H., O'Neill, D., . . . Robson, C. N. (2013). Deubiquitinating Enzyme Usp12 Is a Novel Co-activator of the Androgen Receptor. JOURNAL OF BIOLOGICAL CHEMISTRY, 288(45), 32641-32650. doi:10.1074/jbc.M113.485912

    DOI: 10.1074/jbc.M113.485912