Professor Sir Munir Pirmohamed MB ChB (Hons), MRCP, PhD, FRCP, FRCP(E), FBPharmacolS

Professor (Clin,Hcc) Pharmacology & Therapeutics

+44 (0)151 794 5549
Work email Munirp@liverpool.ac.uk
Personal Websitehttp://liv.ac.uk/pharmacogenetics/

Publications

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2022

Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials (Journal article)

Asiimwe, I. G., Pushpakom, S. P., Turner, R. M., Kolamunnage-Dona, R., Jorgensen, A. L., & Pirmohamed, M. (2022). Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. doi:10.1111/bcp.15331

DOI: 10.1111/bcp.15331

Factors Affecting Patient and Physician Engagement in Remote Health Care for Heart Failure: Systematic Review. (Journal article)

Al-Naher, A., Downing, J., Scott, K. A., & Pirmohamed, M. (2022). Factors Affecting Patient and Physician Engagement in Remote Health Care for Heart Failure: Systematic Review.. JMIR cardio, 6(1), e33366. doi:10.2196/33366

DOI: 10.2196/33366

Ethnic Diversity and Warfarin Pharmacogenomics (Journal article)

Asiimwe, I. G., & Pirmohamed, M. (n.d.). Ethnic Diversity and Warfarin Pharmacogenomics. Frontiers in Pharmacology, 13. doi:10.3389/fphar.2022.866058

DOI: 10.3389/fphar.2022.866058

Pharmacogenomics: Relevance and opportunities for clinical pharmacology (Journal article)

Turner, R. M., Magavern, E. F., & Pirmohamed, M. (2022). Pharmacogenomics: Relevance and opportunities for clinical pharmacology. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. doi:10.1111/bcp.15329

DOI: 10.1111/bcp.15329

Similarity and Consistency Assessment of Three Major Online Drug-Drug Interaction Resources (Journal article)

Kontsioti, E., Maskell, S., Bensalem, A., Dutta, B., & Pirmohamed, M. (2022). Similarity and Consistency Assessment of Three Major Online Drug-Drug Interaction Resources. British Journal of Clinical Pharmacology. doi:10.1111/bcp.15341

DOI: 10.1111/bcp.15341

DEVELOPMENT OF THE ANTICHOLINERGIC MEDICATION INDEX (ACMI) (Conference Paper)

Best, K., Alderson, S., Alldred, D., Bonnet, L., Buchan, I., Butters, O., . . . Clegg, A. (2022). DEVELOPMENT OF THE ANTICHOLINERGIC MEDICATION INDEX (ACMI). In AGE AND AGEING Vol. 51. doi:10.1093/ageing/afac035.825

DOI: 10.1093/ageing/afac035.825

T CELL-MEDIATED HYPERSENSITIVITY TO LUMACAFTOR AND IVACAFTOR IN CYSTIC FIBROSIS (Journal article)

Semic-Jusufagic, A., Ogese, M., Edwards, C., Wilkinson, M., Nissenbaum, C., Lee, T., . . . Naisbitt, D. (2022). T CELL-MEDIATED HYPERSENSITIVITY TO LUMACAFTOR AND IVACAFTOR IN CYSTIC FIBROSIS. doi:10.22541/au.164672762.25283352/v1

DOI: 10.22541/au.164672762.25283352/v1

A reference set of clinically relevant adverse drug-drug interactions (Journal article)

Kontsioti, E., Maskell, S., Dutta, B., & Pirmohamed, M. (2022). A reference set of clinically relevant adverse drug-drug interactions. SCIENTIFIC DATA, 9(1). doi:10.1038/s41597-022-01159-y

DOI: 10.1038/s41597-022-01159-y

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity (Journal article)

Hammond, S., Olsson-Brown, A., Grice, S., Gibson, A., Gardner, J., Castrejon-Flores, J. L., . . . Naisbitt, D. J. (2022). Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity. TOXICOLOGICAL SCIENCES, 186(1), 58-69. doi:10.1093/toxsci/kfab144

DOI: 10.1093/toxsci/kfab144

A population study of clinically actionable genetic variation affecting drug response from the Middle East (Journal article)

Jithesh, P. V., Abuhaliqa, M., Syed, N., Ahmed, I., El Anbari, M., Bastaki, K., . . . Consortiu, Q. G. P. R. (2022). A population study of clinically actionable genetic variation affecting drug response from the Middle East. NPJ GENOMIC MEDICINE, 7(1). doi:10.1038/s41525-022-00281-5

DOI: 10.1038/s41525-022-00281-5

Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials (Journal article)

Asiimwe, I., Pushpakom, S., Turner, R., Kolamunnage-Dona, R., Jorgensen, A., & Pirmohamed, M. (2022). Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials. doi:10.22541/au.164431813.39836023/v1

DOI: 10.22541/au.164431813.39836023/v1

Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01. (Journal article)

Gardner, J., Ogese, M., Betts, C. J., Pirmohamed, M., & Naisbitt, D. J. (2022). Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01.. Chemical research in toxicology, 35(2), 199-202. doi:10.1021/acs.chemrestox.1c00425

DOI: 10.1021/acs.chemrestox.1c00425

A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers (Journal article)

Whitfield, J. B., Schwantes-An, T. -H., Darlay, R., Aithal, G. P., Atkinson, S. R., Bataller, R., . . . Consortium, G. (2022). A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers. JOURNAL OF HEPATOLOGY, 76(2), 275-282. doi:10.1016/j.jhep.2021.10.005

DOI: 10.1016/j.jhep.2021.10.005

Vitamin D, vitamin D-binding protein, free vitamin D and COVID-19 mortality in hospitalized patients (Journal article)

Subramanian, S., Rhodes, J. M., Taylor, J. M., Milan, A. M., Lane, S., Hewison, M., . . . Pirmohamed, M. (2022). Vitamin D, vitamin D-binding protein, free vitamin D and COVID-19 mortality in hospitalized patients. AMERICAN JOURNAL OF CLINICAL NUTRITION. doi:10.1093/ajcn/nqac027

DOI: 10.1093/ajcn/nqac027

Challenges in cardiovascular pharmacogenomics implementation: a viewpoint from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy (Journal article)

Magavern, E. F., Kaski, J. C., Turner, R. M., Drexel, H., Janmohamed, A., Scourfield, A., . . . Caulfield, M. J. (2022). Challenges in cardiovascular pharmacogenomics implementation: a viewpoint from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy. EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, 8(1), 100-103. doi:10.1093/ehjcvp/pvab063

DOI: 10.1093/ehjcvp/pvab063

Chromosomal Region 11p14.1 is Associated with Pharmacokinetics and Pharmacodynamics of Bisoprolol (Journal article)

Fontana, V., Turner, R. M., Francis, B., Yin, P., Puetz, B., Hiltunen, T. P., . . . Pirmohamed, M. (2022). Chromosomal Region 11p14.1 is Associated with Pharmacokinetics and Pharmacodynamics of Bisoprolol. PHARMACOGENOMICS & PERSONALIZED MEDICINE, 15, 249-260. doi:10.2147/PGPM.S352719

DOI: 10.2147/PGPM.S352719

Emerging technologies and their impact on regulatory science (Journal article)

Anklam, E., Bahl, M. I., Ball, R., Beger, R. D., Cohen, J., Fitzpatrick, S., . . . Slikker, W. J. J. (2022). Emerging technologies and their impact on regulatory science. EXPERIMENTAL BIOLOGY AND MEDICINE, 247(1), 1-75. doi:10.1177/15353702211052280

DOI: 10.1177/15353702211052280

Pharmacogenomics of Drug Hypersensitivity (Journal article)

Kuruvilla, R., Scott, K., & Pirmohamed, S. M. (2022). Pharmacogenomics of Drug Hypersensitivity: Technology and Translation.. Immunology and allergy clinics of North America, 42(2), 335-355. doi:10.1016/j.iac.2022.01.006

DOI: 10.1016/j.iac.2022.01.006

Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm (Journal article)

Asiimwe, I. G., Blockman, M., Cohen, K., Cupido, C., Hutchinson, C., Jacobson, B., . . . Pirmohamed, M. (2022). Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm. CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 11(1), 20-29. doi:10.1002/psp4.12740

DOI: 10.1002/psp4.12740

2021

Plasma Methylmalonic Acid Concentration in Folic Acid-Supplemented Depressed Patients with Low or Marginal Vitamin B-12: A Randomized Trial (Journal article)

Carter, B., Zenasni, Z., Moat, S. J., Hudson, P. R., Russell, I. T., McCaddon, A., & Grp, F. (2021). Plasma Methylmalonic Acid Concentration in Folic Acid-Supplemented Depressed Patients with Low or Marginal Vitamin B-12: A Randomized Trial. JOURNAL OF NUTRITION, 151(12), 3738-3745. doi:10.1093/jn/nxab280

DOI: 10.1093/jn/nxab280

Genome-Wide association between EYA1 and Aspirin-induced peptic ulceration (Journal article)

Bourgeois, S., Carr, D. F., Musumba, C. O., Penrose, A., Esume, C., Morris, A. P., . . . Pirmohamed, M. (2021). Genome-Wide association between EYA1 and Aspirin-induced peptic ulceration. EBioMedicine, 74, 103728. doi:10.1016/j.ebiom.2021.103728

DOI: 10.1016/j.ebiom.2021.103728

Clinical and pharmacogenetic determinants of tenofovir-induced renal toxicity in HIV positive patients in Zambia (Conference Paper)

Hamachila, A., Pushpakom, S., Jorgensen, A., & Pirmohamed, M. (2021). Clinical and pharmacogenetic determinants of tenofovir-induced renal toxicity in HIV positive patients in Zambia. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 87 (pp. 4889). Retrieved from http://gateway.webofknowledge.com/

Development of an Adverse Event Reporting Button for a Veterinary Practice Management System (Conference Paper)

Davies, H., Smyth, S., Noble, P. J., Pinchbeck, G., Diesel, G., Pirmohamed, M., & Killick, D. (2021). Development of an Adverse Event Reporting Button for a Veterinary Practice Management System. In DRUG SAFETY Vol. 44 (pp. 1461-1462). Retrieved from http://gateway.webofknowledge.com/

SJS/TEN 2019: From science to translation (vol 98, pg 2, 2020) (Journal article)

Chang, W. -C., Abe, R., Anderson, P., Anderson, W., Ardern-Jones, M. R., Beachkofsky, T. M., . . . Carleton, B. C. (2021). SJS/TEN 2019: From science to translation (vol 98, pg 2, 2020). JOURNAL OF DERMATOLOGICAL SCIENCE, 104(2), 146-147. doi:10.1016/j.jdermsci.2021.09.0080923-1811

DOI: 10.1016/j.jdermsci.2021.09.0080923-1811

High-mobility group box 1 as a predictive biomarker for drug-resistant epilepsy: A proof-of-concept study (Journal article)

Walker, L. E., Sills, G. J., Jorgensen, A., Alapirtti, T., Peltola, J., Brodie, M. J., . . . Pirmohamed, M. (2021). High-mobility group box 1 as a predictive biomarker for drug-resistant epilepsy: A proof-of-concept study. EPILEPSIA. doi:10.1111/epi.17116

DOI: 10.1111/epi.17116

Roadmap to 2030 for Drug Evaluation in Older Adults (Journal article)

Liu, Q., Schwartz, J. B., Slattum, P. W., Lau, S. W. J., Guinn, D., Madabushi, R., . . . Temple, R. (2021). Roadmap to 2030 for Drug Evaluation in Older Adults. CLINICAL PHARMACOLOGY & THERAPEUTICS. doi:10.1002/cpt.2452

DOI: 10.1002/cpt.2452

Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume (Journal article)

Thompson, A., King, K., Morris, A. P., & Pirmohamed, M. (2021). Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume. HUMAN MOLECULAR GENETICS, 30(21), 2040-2051. doi:10.1093/hmg/ddab147

DOI: 10.1093/hmg/ddab147

Corrigendum to ‘SJS/TEN 2019: From science to translation’ [J. Dermatol. Sci. 98/1 (2020) 2–12] (Journal article)

Chang, W. -C., Abe, R., Anderson, P., Anderson, W., Ardern-Jones, M. R., Beachkofsky, T. M., . . . Carleton, B. C. (2021). Corrigendum to ‘SJS/TEN 2019: From science to translation’ [J. Dermatol. Sci. 98/1 (2020) 2–12]. Journal of Dermatological Science, 104(2), 146-147. doi:10.1016/j.jdermsci.2021.09.008

DOI: 10.1016/j.jdermsci.2021.09.008

Developing and Validating a Clinical Warfarin Dose-Initiation Model for Black-African Patients in South Africa and Uganda (vol 109, pg 1564, 2021) (Journal article)

Asiimwe, I. G., Waitt, C., Sekaggya-Wiltshire, C., Hutchinson, C., Okello, E., Zhang, E. J., . . . Pirmohamed, M. (2021). Developing and Validating a Clinical Warfarin Dose-Initiation Model for Black-African Patients in South Africa and Uganda (vol 109, pg 1564, 2021). CLINICAL PHARMACOLOGY & THERAPEUTICS, 110(5), 1402. doi:10.1002/cpt.2395

DOI: 10.1002/cpt.2395

Factors Affecting Patient and Physician Engagement in Remote Health Care for Heart Failure: Systematic Review (Preprint) (Journal article)

Al-Naher, A., Downing, J., Scott, K. A., & Pirmohamed, M. (n.d.). Factors Affecting Patient and Physician Engagement in Remote Health Care for Heart Failure: Systematic Review (Preprint). doi:10.2196/preprints.33366

DOI: 10.2196/preprints.33366

HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction. (Journal article)

Jaruthamsophon, K., Thomson, P. J., Sukasem, C., Naisbitt, D. J., & Pirmohamed, M. (2021). HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction.. Annual review of pharmacology and toxicology, 62, 509-529. doi:10.1146/annurev-pharmtox-052120-014115

DOI: 10.1146/annurev-pharmtox-052120-014115

Improving anticoagulation in sub-Saharan Africa: What are the challenges and how can we overcome them? (Journal article)

Mouton, J. P., Blockman, M., Sekaggya-Wiltshire, C., Semakula, J., Waitt, C., Pirmohamed, M., & Cohen, K. (2021). Improving anticoagulation in sub-Saharan Africa: What are the challenges and how can we overcome them?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(8), 3056-3068. doi:10.1111/bcp.14768

DOI: 10.1111/bcp.14768

Identification of ROBO2 as a Potential Locus Associated with Inhaled Corticosteroid Response in Childhood Asthma (Journal article)

Hernandez-Pacheco, N., Gorenjak, M., Li, J., Repnik, K., Vijverberg, S. J., Berce, V., . . . Pino-Yanes, M. (n.d.). Identification of ROBO2 as a Potential Locus Associated with Inhaled Corticosteroid Response in Childhood Asthma. Journal of Personalized Medicine, 11(8), 733. doi:10.3390/jpm11080733

DOI: 10.3390/jpm11080733

AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter (Journal article)

Griffiths, G. O., FitzGerald, R., Jaki, T., Corkhill, A., Reynolds, H., Ewings, S., . . . Invest, A. G. I. L. E. (2021). AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter. TRIALS, 22(1). doi:10.1186/s13063-021-05458-4

DOI: 10.1186/s13063-021-05458-4

Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01 (Journal article)

Ogese, M. O., Lister, A., Gardner, J., Meng, X., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2021). Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01. TOXICOLOGICAL SCIENCES, 183(1), 139-153. doi:10.1093/toxsci/kfab084

DOI: 10.1093/toxsci/kfab084

Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity (Journal article)

McEvoy, L., Carr, D. F., & Pirmohamed, M. (2021). Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity. FRONTIERS IN PHARMACOLOGY, 12. doi:10.3389/fphar.2021.684162

DOI: 10.3389/fphar.2021.684162

Cardiovascular drugs and COVID-19 clinical outcomes: A living systematic review and meta-analysis (Journal article)

Asiimwe, I. G., Pushpakom, S., Turner, R. M., Kolamunnage-Dona, R., Jorgensen, A. L., & Pirmohamed, M. (2021). Cardiovascular drugs and COVID-19 clinical outcomes: A living systematic review and meta-analysis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(12), 4534-+. doi:10.1111/bcp.14927

DOI: 10.1111/bcp.14927

Developing and Validating a Clinical Warfarin Dose-Initiation Model for Black-African Patients in South Africa and Uganda (Journal article)

Asiimwe, I. G., Waitt, C., Sekaggya-Wiltshire, C., Hutchinson, C., Okello, E., Zhang, E. J., . . . Pirmohamed, M. (2021). Developing and Validating a Clinical Warfarin Dose-Initiation Model for Black-African Patients in South Africa and Uganda. CLINICAL PHARMACOLOGY & THERAPEUTICS, 109(6), 1564-1574. doi:10.1002/cpt.2128

DOI: 10.1002/cpt.2128

Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine (Journal article)

Yip, V. L. M., Pertinez, H., Meng, X., Maggs, J. L., Carr, D. F., Park, B. K., . . . Pirmohamed, M. (2021). Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(6), 2572-2588. doi:10.1111/bcp.14667

DOI: 10.1111/bcp.14667

The Interface of Therapeutics and Genomics in Cardiovascular Medicine (Journal article)

Magavern, E. F., Kaski, J. C., Turner, R. M., Janmohamed, A., Borry, P., & Pirmohamed, M. (2021). The Interface of Therapeutics and Genomics in Cardiovascular Medicine. CARDIOVASCULAR DRUGS AND THERAPY, 35(3), 663-676. doi:10.1007/s10557-021-07149-3

DOI: 10.1007/s10557-021-07149-3

T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab (Journal article)

Hammond, S., Olsson-Brown, A., Gardner, J., Thomson, P., Ali, S. -E., Jolly, C., . . . Naisbitt, D. (2021). T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 9(5). doi:10.1136/jitc-2021-002521

DOI: 10.1136/jitc-2021-002521

HLA-B*13:01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients (Journal article)

Satapornpong, P., Pratoomwun, J., Rerknimitr, P., Klaewsongkram, J., Nakkam, N., Rungrotmongkol, T., . . . Sukasem, C. (2021). HLA-B*13:01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.661135

DOI: 10.3389/fimmu.2021.661135

Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort (Journal article)

Nicoletti, P., Carr, D. F., Barrett, S., McEvoy, L., Friedmann, P. S., Shear, N. H., . . . Pirmohamed, M. (n.d.). Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort. Journal of Allergy and Clinical Immunology. doi:10.1016/j.jaci.2020.10.004

DOI: 10.1016/j.jaci.2020.10.004

Genome-wide Association Study and Meta-analysis on Alcohol-Associated Liver Cirrhosis Identifies Genetic Risk Factors (Journal article)

Schwantes-An, T. -H., Darlay, R., Mathurin, P., Masson, S., Liangpunsakul, S., Mueller, S., . . . Consortium, G. (2021). Genome-wide Association Study and Meta-analysis on Alcohol-Associated Liver Cirrhosis Identifies Genetic Risk Factors. HEPATOLOGY, 73(5), 1920-1931. doi:10.1002/hep.31535

DOI: 10.1002/hep.31535

Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use (Journal article)

Hernandez-Pacheco, N., Vijverberg, S. J., Herrera-Luis, E., Li, J., Sio, Y. Y., Granell, R., . . . Consortia, P. I. C. A. S. (2021). Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use. EUROPEAN RESPIRATORY JOURNAL, 57(5). doi:10.1183/13993003.03388-2020

DOI: 10.1183/13993003.03388-2020

Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing HLA-B*13:01 (Journal article)

Pratoomwun, J., Thomson, P., Jaruthamsophon, K., Tiyasirichokchai, R., Jinda, P., Rerkpattanapipat, T., . . . Sukasem, C. (2021). Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing HLA-B*13:01. FRONTIERS IN IMMUNOLOGY, 12. doi:10.3389/fimmu.2021.658593

DOI: 10.3389/fimmu.2021.658593

HLA-DQB1 6672G > C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry (Journal article)

Konte, B., Walters, J. T. R., Rujescu, D., Legge, S. E., Pardinas, A. F., Cohen, D., . . . Giegling, I. (2021). HLA-DQB1 6672G > C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry. TRANSLATIONAL PSYCHIATRY, 11(1). doi:10.1038/s41398-021-01322-w

DOI: 10.1038/s41398-021-01322-w

T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses (Journal article)

Ogbe, A., Kronsteiner, B., Skelly, D. T., Pace, M., Brown, A., Adland, E., . . . Oxford, P. T. C. (2021). T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-21856-3

DOI: 10.1038/s41467-021-21856-3

Combined analysis of transcriptomic and genetic data for the identification of loci involved in glucocorticosteroid response in asthma (Journal article)

Hernandez-Pacheco, N., Gorenjak, M., Jurgec, S., Corrales, A., Jorgensen, A., Karimi, L., . . . Consortia, P. S. (2021). Combined analysis of transcriptomic and genetic data for the identification of loci involved in glucocorticosteroid response in asthma. ALLERGY, 76(4), 1238-1243. doi:10.1111/all.14552

DOI: 10.1111/all.14552

Genetic risk factors in drug-induced liver injury due to isoniazid-containing anti-tuberculosis drug regimens. (Journal article)

Nicoletti, P., Devarbhavi, H., Goel, A., Venkatesan, R., Eapen, C. E., Grove, J. I., . . . Aithal, G. P. (2020). Genetic risk factors in drug-induced liver injury due to isoniazid-containing anti-tuberculosis drug regimens.. Clinical Pharmacology and Therapeutics. doi:10.1002/cpt.2100

DOI: 10.1002/cpt.2100

Warfarin dosing algorithms: A systematic review (Journal article)

Asiimwe, I. G., Zhang, E. J., Osanlou, R., Jorgensen, A. L., & Pirmohamed, M. (2021). Warfarin dosing algorithms: A systematic review. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(4), 1717-1729. doi:10.1111/bcp.14608

DOI: 10.1111/bcp.14608

HLA Class-II. Restricted CD8(+) T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients (Journal article)

Zhao, Q., Almutairi, M., Tailor, A., Lister, A., Harper, N., Line, J., . . . Naisbitt, D. J. (2021). HLA Class-II. Restricted CD8(+) T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141(10), 2412-+. doi:10.1016/j.jid.2021.03.014

DOI: 10.1016/j.jid.2021.03.014

Anticoagulation in sub-Saharan Africa: Are Direct Oral Anticoagulants the answer? A review of lessons learnt from warfarin (Journal article)

Semakula, J., Kisa, G., Mouton, J., Cohen, K., Blockman, M., Pirmohamed, M., . . . Waitt, C. (2021). Anticoagulation in sub-Saharan Africa: Are Direct Oral Anticoagulants the answer? A review of lessons learnt from warfarin. British Journal of Clinical Pharmacology. doi:10.1111/bcp.14796

DOI: 10.1111/bcp.14796

A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COVID-19 (SARS-COV-2) treatments (Journal article)

Baker, E. H., Gnjidic, D., Kirkpatrick, C. M. J., Pirmohamed, M., Wright, D. F. B., & Zecharia, A. Y. (2021). A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COVID-19 (SARS-COV-2) treatments. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(3), 707-711. doi:10.1111/bcp.14416

DOI: 10.1111/bcp.14416

Cutaneous expression of matrix metalloproteinase 9 in SJS/TEN: Putative role in the pathogenesis of epidermal detachment and possible therapeutic target (Conference Paper)

Carr, D., Olsson-Brown, A., Yip, V., & Pirmohamed, M. (2021). Cutaneous expression of matrix metalloproteinase 9 in SJS/TEN: Putative role in the pathogenesis of epidermal detachment and possible therapeutic target. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 87 (pp. 1621-1622). Retrieved from http://gateway.webofknowledge.com/

Dimethyl fumarate induced lymphopenia in multiple sclerosis: A review of the literature (Journal article)

Russo, C. D., Scott, K. A., & Pirmohamed, M. (2021). Dimethyl fumarate induced lymphopenia in multiple sclerosis: A review of the literature. PHARMACOLOGY & THERAPEUTICS, 219. doi:10.1016/j.pharmthera.2020.107710

DOI: 10.1016/j.pharmthera.2020.107710

Cardiovascular drugs and COVID-19 clinical outcomes: a living systematic review and meta-analysis (Journal article)

Asiimwe, I., Pushpakon, S., Turner, R., Kolamunnage-Dona, R., Jorgensen, A., & Pirmohamed, M. (2021). Cardiovascular drugs and COVID-19 clinical outcomes: a living systematic review and meta-analysis. doi:10.22541/au.161452914.41833841/v1

DOI: 10.22541/au.161452914.41833841/v1

The role of pharmacogenomics in contemporary cardiovascular therapy: a position statement from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy (Journal article)

Magavern, E. F., Kaski, J. C., Turner, R. M., Drexel, H., Janmohamed, A., Scourfield, A., . . . Caulfield, M. J. (2022). The role of pharmacogenomics in contemporary cardiovascular therapy: a position statement from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy. EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, 8(1), 85-99. doi:10.1093/ehjcvp/pvab018

DOI: 10.1093/ehjcvp/pvab018

Associations between occupation and heavy alcohol consumption in UK adults aged 40-69 years: a cross-sectional study using the UK Biobank (Journal article)

Thompson, A., & Pirmohamed, M. (2021). Associations between occupation and heavy alcohol consumption in UK adults aged 40-69 years: a cross-sectional study using the UK Biobank. BMC PUBLIC HEALTH, 21(1). doi:10.1186/s12889-021-10208-x

DOI: 10.1186/s12889-021-10208-x

Inflammatory Bowel Disease: A Personalized Approach. (Journal article)

Konidari, A., Dickens, D., & Pirmohamed, M. (2021). Inflammatory Bowel Disease: A Personalized Approach.. Frontiers in Pediatrics, 8, 620545. doi:10.3389/fped.2020.620545

DOI: 10.3389/fped.2020.620545

Pharmacogenomics of anticancer drugs: Personalising the choice and dose to manage drug response (Journal article)

Carr, D. F., Turner, R. M., & Pirmohamed, M. (2021). Pharmacogenomics of anticancer drugs: Personalising the choice and dose to manage drug response. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87(2), 237-255. doi:10.1111/bcp.14407

DOI: 10.1111/bcp.14407

Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex (Journal article)

Patel, W., Rimmer, L., Smith, M., Moss, L., Smith, M. A., Snodgrass, H. R., . . . Dickens, D. (2021). Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex. MOLECULAR PHARMACEUTICS, 18(1), 113-123. doi:10.1021/acs.molpharmaceut.0c00727

DOI: 10.1021/acs.molpharmaceut.0c00727

Probenecid increases the concentration of 7-chlorokynurenic acid derived from the prodrug 4-chlorokynurenine within the prefrontal cortex (Conference Paper)

Patel, W., Rimmer, L., Smith, M., Moss, L., Smith, M., Snodgrass, R., . . . Dickens, D. (2021). Probenecid increases the concentration of 7-chlorokynurenic acid derived from the prodrug 4-chlorokynurenine within the prefrontal cortex. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 178 (pp. 463). Retrieved from http://gateway.webofknowledge.com/

Sequential Association Rule Mining Revisited: A Study Directed at Relational Pattern Mining for Multi-morbidity (Conference Paper)

Vincent-Paulraj, A., Burnside, G., Coenen, F., Pirmohamed, M., & Walker, L. (2021). Sequential Association Rule Mining Revisited: A Study Directed at Relational Pattern Mining for Multi-morbidity. In ARTIFICIAL INTELLIGENCE XXXVIII Vol. 13101 (pp. 241-253). doi:10.1007/978-3-030-91100-3_20

DOI: 10.1007/978-3-030-91100-3_20

2020

Multimorbidity, polypharmacy, and drug-drug-gene interactions following a non-ST elevation acute coronary syndrome: analysis of a multicentre observational study (Journal article)

Turner, R. M., de Koning, E. M., Fontana, V., Thompson, A., & Pirmohamed, M. (2020). Multimorbidity, polypharmacy, and drug-drug-gene interactions following a non-ST elevation acute coronary syndrome: analysis of a multicentre observational study. BMC MEDICINE, 18(1). doi:10.1186/s12916-020-01827-z

DOI: 10.1186/s12916-020-01827-z

Examining the uptake of predictive BRCA testing in the UK; findings and implications (Journal article)

Martin, A., Downing, J., Collins, B., Godman, B., Alfirevic, A., Greenhalgh, L., & Pirmohamed, M. (2020). Examining the uptake of predictive BRCA testing in the UK; findings and implications. European Journal of Human Genetics, 2020. doi:10.1038/s41431-020-00783-9

DOI: 10.1038/s41431-020-00783-9

Monitoring indirect impact of COVID-19 pandemic on services for cardiovascular diseases in the UK (Journal article)

Ball, S., Banerjee, A., Berry, C., Boyle, J. R., Bray, B., Bradlow, W., . . . Wyatt, M. (2020). Monitoring indirect impact of COVID-19 pandemic on services for cardiovascular diseases in the UK. HEART, 106(24), 1890-1897. doi:10.1136/heartjnl-2020-317870

DOI: 10.1136/heartjnl-2020-317870

Pharmacogenomics for Primary Care: An Overview (Journal article)

Rollinson, V., Turner, R., & Pirmohamed, M. (2020). Pharmacogenomics for Primary Care: An Overview. GENES, 11(11). doi:10.3390/genes11111337

DOI: 10.3390/genes11111337

Alcohol-related brain injury: An unrecognized problem in acute medicine (Journal article)

Thompson, A., Richardson, P., Pirmohamed, M., & Owens, L. (2020). Alcohol-related brain injury: An unrecognized problem in acute medicine. ALCOHOL, 88, 49-53. doi:10.1016/j.alcohol.2020.05.005

DOI: 10.1016/j.alcohol.2020.05.005

Characterization of Clozapine-Responsive Human T Cells (Journal article)

Ogese, M. O., Lister, A., Jenkins, R. E., Meng, X., Alfirevic, A., Douglas, L., . . . Naisbitt, D. J. (2020). Characterization of Clozapine-Responsive Human T Cells. JOURNAL OF IMMUNOLOGY, 205(9), 2375-+. doi:10.4049/jimmunol.2000646

DOI: 10.4049/jimmunol.2000646

HLA DaB115:01-DQB106:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts (Journal article)

Tailor, A., Meng, X., Adair, K., Farrell, J., Waddington, J. C., Daly, A., . . . Naisbitt, D. J. (2020). HLA DaB1*15:01-DQB1*06:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts. TOXICOLOGICAL SCIENCES, 178(1), 115-126. doi:10.1093/toxsci/kfaa128

DOI: 10.1093/toxsci/kfaa128

Pharmacogenomics in the UK National Health Service: opportunities and challenges (Journal article)

Turner, R. M., Newman, W. G., Bramon, E., McNamee, C. J., Wong, W. L., Misbah, S., . . . Pirmohamed, M. (2020). Pharmacogenomics in the UK National Health Service: opportunities and challenges. Pharmacogenomics, 21(17), 1237-1246. doi:10.2217/pgs-2020-0091

DOI: 10.2217/pgs-2020-0091

A Review of the Important Role of CYP2D6 in Pharmacogenomics (Journal article)

Taylor, C., Crosby, I., Yip, V., Maguire, P., Pirmohamed, M., & Turner, R. M. (2020). A Review of the Important Role of CYP2D6 in Pharmacogenomics. GENES, 11(11). doi:10.3390/genes11111295

DOI: 10.3390/genes11111295

Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation (Journal article)

Waddington, J. C., Meng, X., Illing, P. T., Tailor, A., Adair, K., Whitaker, P., . . . Park, B. K. (2020). Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation. TOXICOLOGICAL SCIENCES, 177(2), 454-465. doi:10.1093/toxsci/kfaa124

DOI: 10.1093/toxsci/kfaa124

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation (Conference Paper)

King, C., McKenna, A., Farzan, N., Vijverberg, S. J., van der Schee, M. P., Maitland-van der Zee, A. H., . . . Hawcutt, D. B. (2020). Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation. In PHARMACOGENOMICS JOURNAL Vol. 20 (pp. 621-628). doi:10.1038/s41397-019-0140-y

DOI: 10.1038/s41397-019-0140-y

Precision medicine in drug safety (Journal article)

Carr, D. F., & Pirmohamed, M. (2020). Precision medicine in drug safety. Current Opinion in Toxicology, 23-24, 87-97. doi:10.1016/j.cotox.2020.07.003

DOI: 10.1016/j.cotox.2020.07.003

Safety perspectives on presently considered drugs for the treatment of COVID-19 (Journal article)

Penman, S. L., Kiy, R. T., Jensen, R. L., Beoku-Betts, C., Alfirevic, A., Back, D., . . . Chadwick, A. E. (n.d.). Safety perspectives on presently considered drugs for the treatment of COVID-19. British Journal of Pharmacology. doi:10.1111/bph.15204

DOI: 10.1111/bph.15204

Beyond corticosteroids for the management of patients with cutaneous immune-related adverse events secondary to immune checkpoint inhibitors (Conference Paper)

Yip, V., Olsson-Brown, A., Carr, D., Pirmohamed, M., & Hindle, E. (2020). Beyond corticosteroids for the management of patients with cutaneous immune-related adverse events secondary to immune checkpoint inhibitors. In BRITISH JOURNAL OF DERMATOLOGY Vol. 183 (pp. 136). Retrieved from http://gateway.webofknowledge.com/

Obesity, Diabetes, Coffee, Tea, and Cannabis Use Alter Risk for Alcohol-Related Cirrhosis in 2 Large Cohorts of High-Risk Drinkers. (Journal article)

Whitfield, J. B., Masson, S., Liangpunsakul, S., Mueller, S., Aithal, G. P., Eyer, F., . . . GenomALC Consortium. (2020). Obesity, Diabetes, Coffee, Tea, and Cannabis Use Alter Risk for Alcohol-Related Cirrhosis in 2 Large Cohorts of High-Risk Drinkers.. The American journal of gastroenterology. doi:10.14309/ajg.0000000000000833

DOI: 10.14309/ajg.0000000000000833

Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II). (Journal article)

Balabanova, S., Taylor, C., Sills, G., Burnside, G., Plumpton, C., Smith, P. E. M., . . . Marson, A. G. (2020). Study protocol for a pragmatic randomised controlled trial comparing the effectiveness and cost-effectiveness of levetiracetam and zonisamide versus standard treatments for epilepsy: a comparison of standard and new antiepileptic drugs (SANAD-II).. BMJ open, 10(8), e040635. doi:10.1136/bmjopen-2020-040635

DOI: 10.1136/bmjopen-2020-040635

The longitudinal NIHR ARC North West Coast Household Health Survey: Exploring health inequalities in disadvantaged communities (Journal article)

Giebel, C., McIntyre, J., Alfirevic, A., Corcoran, R., Daras, K., Downing, J., . . . Barr, B. (2020). The longitudinal NIHR ARC North West Coast Household Health Survey: Exploring health inequalities in disadvantaged communities. BMC Public Health, 20. doi:10.1186/s12889-020-09346-5

DOI: 10.1186/s12889-020-09346-5

A Genome-wide Association Study of Circulating Levels of Atorvastatin and Its Major Metabolites (Journal article)

Turner, R. M., Fontana, V., Zhang, J. E., Carr, D., Yin, P., FitzGerald, R., . . . Pirmohamed, M. (2020). A Genome-wide Association Study of Circulating Levels of Atorvastatin and Its Major Metabolites. Clinical Pharmacology and Therapeutics, 108(2), 287-297. doi:10.1002/cpt.1820

DOI: 10.1002/cpt.1820

Correction: Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritization (Journal article)

King, C., McKenna, A., Farzan, N., Vijverberg, S. J., van der Schee, M. P., Maitland-van der Zee, A. H., . . . Hawcutt, D. B. (2020). Correction: Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritization. Pharmacogenomics J. doi:10.1038/s41397-020-0178-x

DOI: 10.1038/s41397-020-0178-x

Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes (Journal article)

Sukasem, C., Pratoomwun, J., Satapornpong, P., Klaewsongkram, J., Rerkpattanapipat, T., Rerknimitr, P., . . . Pirmohamed, M. (2020). Genetic Association of Co-Trimoxazole-Induced Severe Cutaneous Adverse Reactions Is Phenotype-Specific: HLA Class I Genotypes and Haplotypes. Clinical Pharmacology and Therapeutics. doi:10.1002/cpt.1915

DOI: 10.1002/cpt.1915

Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way? (Journal article)

Cheung, V. T. F., Gupta, T., Olsson-Brown, A., Subramanian, S., Sasson, S. C., Heseltine, J., . . . Brain, O. (2020). Immune checkpoint inhibitor-related colitis assessment and prognosis: can IBD scoring point the way?. BRITISH JOURNAL OF CANCER, 123(2), 207-215. doi:10.1038/s41416-020-0882-y

DOI: 10.1038/s41416-020-0882-y

Pharmacogenetics for the prescriber (Journal article)

Pirmohamed, M. (2020). Pharmacogenetics for the prescriber. Medicine, 48(7), 439-442. doi:10.1016/j.mpmed.2020.04.002

DOI: 10.1016/j.mpmed.2020.04.002

The implementation of pharmacogenomics into UK general practice: a qualitative study exploring barriers, challenges and opportunities. (Journal article)

Rafi, I., Crinson, I., Dawes, M., Rafi, D., Pirmohamed, M., & Walter, F. M. (2020). The implementation of pharmacogenomics into UK general practice: a qualitative study exploring barriers, challenges and opportunities.. Journal of community genetics, 11(3), 269-277. doi:10.1007/s12687-020-00468-2

DOI: 10.1007/s12687-020-00468-2

Pharmacogenomics of anticancer drugs: Personalising the choice and dose to manage drug response (Journal article)

Carr, D., Turner, R. M., & Pirmohamed, M. (n.d.). Pharmacogenomics of anticancer drugs: Personalising the choice and dose to manage drug response. British Journal of Clinical Pharmacology. doi:10.1111/bcp.14407

DOI: 10.1111/bcp.14407

The antidepressant AV-101 is a substrate for LAT1 (SLC7A5) at the blood-brain barrier (Conference Paper)

Patel, W., Smith, M., Snodgrass, R., Pirmohamed, M., Alfirevic, A., & Dickens, D. (2020). The antidepressant AV-101 is a substrate for LAT1 (SLC7A5) at the blood-brain barrier. In BRITISH JOURNAL OF PHARMACOLOGY Vol. 177 (pp. 2621-2622). Retrieved from http://gateway.webofknowledge.com/

Has the introduction of direct oral anticoagulants (DOACs) in England increased emergency admissions for bleeding conditions? A longitudinal ecological study (Journal article)

Alfirevic, A., Downing, J., Daras, K., Comerford, T., Pirmohamed, M., & Barr, B. (2020). Has the introduction of direct oral anticoagulants (DOACs) in England increased emergency admissions for bleeding conditions? A longitudinal ecological study. BMJ Open, 10(5). doi:10.1136/bmjopen-2019-033357

DOI: 10.1136/bmjopen-2019-033357

Serotonin re-uptake transporter gene polymorphisms are associated with imatinib-induced diarrhoea in chronic myeloid leukaemia patients. (Journal article)

Davies, A., Rodriguez-Vicente, A. E., Austin, G., Loaiza, S., Foroni, L., Clark, R. E., & Pirmohamed, M. (2020). Serotonin re-uptake transporter gene polymorphisms are associated with imatinib-induced diarrhoea in chronic myeloid leukaemia patients.. Scientific reports, 10(1). doi:10.1038/s41598-020-65350-0

DOI: 10.1038/s41598-020-65350-0

Immune checkpoint inhibitor-related colitis assessment and prognosis: can inflammatory bowel disease scoring point the way? (Conference Paper)

Cheung, V. T. F., Gupta, T., Olsson-Brown, A., Subramanian, S., Sasson, S. C., Heseltine, J., . . . Brain, O. (2020). Immune checkpoint inhibitor-related colitis assessment and prognosis: can inflammatory bowel disease scoring point the way?. In JOURNAL OF CROHNS & COLITIS Vol. 14 (pp. S286-S288). Retrieved from http://gateway.webofknowledge.com/

TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy (Journal article)

Pushpakom, S. P., Kolamunnage-Dona, R., Taylor, C., Foster, T., Spowart, C., Garcia-Finana, M., . . . Pirmohamed, M. (n.d.). TAILoR (TelmisArtan and InsuLin Resistance in Human Immunodeficiency Virus [HIV]): An Adaptive-design, Dose-ranging Phase IIb Randomized Trial of Telmisartan for the Reduction of Insulin Resistance in HIV-positive Individuals on Combination Antiretroviral Therapy. Clinical Infectious Diseases. doi:10.1093/cid/ciz589

DOI: 10.1093/cid/ciz589

Genetic factors influencing warfarin dose in Black-African patients: a systematic review and meta-analysis. (Journal article)

Asiimwe, I. G., Zhang, E. J., Osanlou, R., Krause, A., Dillon, C., Suarez-Kurtz, G., . . . Pirmohamed, M. (2020). Genetic factors influencing warfarin dose in Black-African patients: a systematic review and meta-analysis.. Clinical Pharmacology and Therapeutics, 107(6), 1420-1433. doi:10.1002/cpt.1755

DOI: 10.1002/cpt.1755

Genetic variants associated with T cell-mediated cutaneous adverse drug reactions: A PRISMA-compliant systematic review-An EAACI position paper (Journal article)

Oussalah, A., Yip, V., Mayorga, C., Blanca, M., Barbaud, A., Nakonechna, A., . . . EAACI. (2020). Genetic variants associated with T cell-mediated cutaneous adverse drug reactions: A PRISMA-compliant systematic review-An EAACI position paper. Allergy, 75(5), 1069-1098. doi:10.1111/all.14174

DOI: 10.1111/all.14174

IMMUNE CHECKPOINT INHIBITOR-RELATED COLITIS ASSESSMENT AND PROGNOSIS: CAN UCEIS, MAYO AND NANCY INDEX SCORING POINT THE WAY? (Conference Paper)

Cheung, V. T., Gupta, T., Olsson-Brown, A. C., Subramanian, S., Sasson, S. C., Heseltine, J., . . . Brain, O. (2020). IMMUNE CHECKPOINT INHIBITOR-RELATED COLITIS ASSESSMENT AND PROGNOSIS: CAN UCEIS, MAYO AND NANCY INDEX SCORING POINT THE WAY?. In GASTROENTEROLOGY Vol. 158 (pp. S535-S536). Retrieved from http://gateway.webofknowledge.com/

Predicting the safety of medicines in pregnancy: A workshop report (Journal article)

Clements, J. M., Hawkes, R. G., Jones, D., Adjei, A., Chambers, T., Simon, L., . . . Sewell, F. (2020). Predicting the safety of medicines in pregnancy: A workshop report. REPRODUCTIVE TOXICOLOGY, 93, 199-210. doi:10.1016/j.reprotox.2020.02.011

DOI: 10.1016/j.reprotox.2020.02.011

SJS/TEN 2019: From science to translation (Journal article)

Chang, W. -C., Abe, R., Anderson, P., Anderson, W., Ardern-Jones, M. R., Beachkofsky, T. M., . . . Carleton, B. C. (2020). SJS/TEN 2019: From science to translation. JOURNAL OF DERMATOLOGICAL SCIENCE, 98(1), 2-12. doi:10.1016/j.jdermsci.2020.02.003

DOI: 10.1016/j.jdermsci.2020.02.003

The recent emergence of a highly related virulent Clostridium difficile clade with unique characteristics (Journal article)

Shaw, H. A., Preston, M. D., Vendrik, K. E. W., Cairns, M. D., Browne, H. P., Stabler, R. A., . . . Wren, B. W. (2020). The recent emergence of a highly related virulent Clostridium difficile clade with unique characteristics. CLINICAL MICROBIOLOGY AND INFECTION, 26(4), 492-498. doi:10.1016/j.cmi.2019.09.004

DOI: 10.1016/j.cmi.2019.09.004

A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (vol 10, 1796, 2020) (Journal article)

McWilliam, S. J., Rosala-Hallas, A., Jones, A. P., Shaw, V., Greenhalf, W., Jaki, T., . . . Pirmohamed, M. (2020). A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis (vol 10, 1796, 2020). SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-61783-9

DOI: 10.1038/s41598-020-61783-9

Characterization of Circulating Clostridium difficile Strains, Host Response and Intestinal Microbiome in Hospitalized Children With Diarrhea (Journal article)

Lees, E. A., Carrol, E. D., Ellaby, N. A. F., Roberts, P., Corless, C. E., Lenzi, L., . . . Pirmohamed, M. (2020). Characterization of Circulating Clostridium difficile Strains, Host Response and Intestinal Microbiome in Hospitalized Children With Diarrhea. The Pediatric infectious disease journal, 39(3), 221-228. doi:10.1097/inf.0000000000002559

DOI: 10.1097/inf.0000000000002559

HLA-DQB1 6672 G > C is associated with the risk of clozapine-induced agranulocytosis in individuals of European ancestry (Conference Paper)

Konte, B., Walters, J. T., Giegling, I., Legge, S., Pardina, A. F., Cohen, D., . . . Rujescu, D. (2020). HLA-DQB1 6672 G > C is associated with the risk of clozapine-induced agranulocytosis in individuals of European ancestry. In PHARMACOPSYCHIATRY Vol. 53 (pp. 88). doi:10.1055/s-0039-3403016

DOI: 10.1055/s-0039-3403016

Two distinct clinical patterns of checkpoint inhibitor-induced thyroid dysfunction (Journal article)

Olsson-Brown, A., Lord, R., Sacco, J., Wagg, J., Coles, M., & Pirmohamed, M. (2020). Two distinct clinical patterns of checkpoint inhibitor-induced thyroid dysfunction. ENDOCRINE CONNECTIONS, 9(4), 318-325. doi:10.1530/EC-19-0473

DOI: 10.1530/EC-19-0473

A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis. (Journal article)

McWilliam, S. J., Rosala-Hallas, A., Jones, A. P., Shaw, V., Greenhalf, W., Jaki, T., . . . Pirmohamed, M. (2020). A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.. Scientific reports, 10(1). doi:10.1038/s41598-020-58790-1

DOI: 10.1038/s41598-020-58790-1

A cross-sectional evaluation of five warfarin anticoagulation services in Uganda and South Africa (Journal article)

Semakula, J. R., Mouton, J. P., Jorgensen, A., Hutchinson, C., Allie, S., Semakula, L., . . . Cohen, K. (2020). A cross-sectional evaluation of five warfarin anticoagulation services in Uganda and South Africa. PLOS ONE, 15(1). doi:10.1371/journal.pone.0227458

DOI: 10.1371/journal.pone.0227458

Genetic associations with clozapine-induced myocarditis in patients with schizophrenia (Journal article)

Lacaze, P., Ronaldson, K. J., Zhang, E. J., Alfirevic, A., Shah, H., Newman, L., . . . Pirmohamed, M. (2020). Genetic associations with clozapine-induced myocarditis in patients with schizophrenia. TRANSLATIONAL PSYCHIATRY, 10(1). doi:10.1038/s41398-020-0722-0

DOI: 10.1038/s41398-020-0722-0

Functional validity, role, and implications of heavy alcohol consumption genetic loci (Journal article)

Thompson, A., Cook, J., Choquet, H., Jorgenson, E., Yin, J., Kinnunen, T., . . . Pirmohamed, M. (2020). Functional validity, role, and implications of heavy alcohol consumption genetic loci. Science Advances, 6(3), eaay5034. doi:10.1126/sciadv.aay5034

DOI: 10.1126/sciadv.aay5034

Investigating the clinical factors and comedications associated with circulating levels of atorvastatin and its major metabolites in secondary prevention (Journal article)

Turner, R. M., Fontana, V., FitzGerald, R., Morris, A. P., & Pirmohamed, M. (2020). Investigating the clinical factors and comedications associated with circulating levels of atorvastatin and its major metabolites in secondary prevention. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 86(1), 62-74. doi:10.1111/bcp.14133

DOI: 10.1111/bcp.14133

Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study (Journal article)

van der Wouden, C. H., Bohringer, S., Cecchin, E., Cheung, K. -C., Lucia Davila-Fajardo, C., Deneer, V. H. M., . . . Consor, U. P. (2020). Generating evidence for precision medicine: considerations made by the Ubiquitous Pharmacogenomics Consortium when designing and operationalizing the PREPARE study. Pharmacogenetics and Genomics, 30(6), 131-144. doi:10.1097/FPC.0000000000000405

DOI: 10.1097/FPC.0000000000000405

Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities (Journal article)

Chenoweth, M. J., Giacomini, K. M., Pirmohamed, M., Hill, S. L., van Schaik, R. H. N., Schwab, M., . . . Tyndale, R. F. (2020). Global Pharmacogenomics Within Precision Medicine: Challenges and Opportunities. CLINICAL PHARMACOLOGY & THERAPEUTICS, 107(1), 57-61. doi:10.1002/cpt.1664

DOI: 10.1002/cpt.1664

WARFARIN: A PARADIGM FOR INDIVIDUALIZED DOSING (Conference Paper)

Pirmohamed, M. (2020). WARFARIN: A PARADIGM FOR INDIVIDUALIZED DOSING. In DRUG METABOLISM AND PHARMACOKINETICS Vol. 35 (pp. S6). Retrieved from http://gateway.webofknowledge.com/

2019

Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle Components (Journal article)

Turner, R. M., & Pirmohamed, M. (2020). Statin-Related Myotoxicity: A Comprehensive Review of Pharmacokinetic, Pharmacogenomic and Muscle Components. JOURNAL OF CLINICAL MEDICINE, 9(1). doi:10.3390/jcm9010022

DOI: 10.3390/jcm9010022

Recommendations for the Use of Social Media in Pharmacovigilance: Lessons from IMI WEB-RADR (Journal article)

van Stekelenborg, J., Ellenius, J., Maskell, S., Bergvall, T., Caster, O., Dasgupta, N., . . . Pirmohamed, M. (2019). Recommendations for the Use of Social Media in Pharmacovigilance: Lessons from IMI WEB-RADR. DRUG SAFETY, 42(12), 1393-1407. doi:10.1007/s40264-019-00858-7

DOI: 10.1007/s40264-019-00858-7

Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink (Journal article)

Carr, D. (2019). Genomewide Association Study of Statin-Induced Myopathy in Patients Recruited Using the UK Clinical Practice Research Datalink. Clinical Pharmacology and Therapeutics, 106(6), 1353-1361. doi:10.1002/cpt.1557

DOI: 10.1002/cpt.1557

CD8+Tcell integrin alpha 4 beta 7expression: a potential predictor of severity and steroid sensitivity in checkpoint inhibitor induced colitis (Conference Paper)

Olsson-Brown, A., Sacco, J., Olsson-Brown, A., Olsson-Brown, A., Cachinho, S., Jolly, C., . . . Pirmohamed, M. (2019). CD8+Tcell integrin alpha 4 beta 7expression: a potential predictor of severity and steroid sensitivity in checkpoint inhibitor induced colitis. In JOURNAL FOR IMMUNOTHERAPY OF CANCER Vol. 7. Retrieved from http://gateway.webofknowledge.com/

Pharmacogene variation in the UK 100,000 Genomes Project: an analysis of 60,221 individuals (Poster)

Turner, R. M., Genomics England Research Consortium., & Pirmohamed, M. (2019). Pharmacogene variation in the UK 100,000 Genomes Project: an analysis of 60,221 individuals. Poster session presented at the meeting of Genomics England Research Conference. London, UK.

Genetic Predisposition to Anticonvulsant Hypersensitivity (Journal article)

Pirmohamed, M. (2019). Genetic Predisposition to Anticonvulsant Hypersensitivity. CLINICAL PHARMACOLOGY & THERAPEUTICS, 106(5), 919-922. doi:10.1002/cpt.1610

DOI: 10.1002/cpt.1610

Prescribing in liver disease (Journal article)

Doogue, M., Martin, J., Miners, J., & Somogyi, A. (2009). Prescribing in liver disease. AUSTRALIAN PRESCRIBER, 32(5), 120. Retrieved from http://gateway.webofknowledge.com/

TRENDS AND UPTAKE OF PREDICTIVE BRCA TESTING (Conference Paper)

Martin, A., Pedra, G., Downing, J., Godman, B., Alfirevic, A., Greenhalgh, K. L., & Pirmohamed, M. (2019). TRENDS AND UPTAKE OF PREDICTIVE BRCA TESTING. In VALUE IN HEALTH Vol. 22 (pp. S428). Retrieved from http://gateway.webofknowledge.com/

Implementation of pharmacogenomics in the clinic (Conference Paper)

Pirmohamed, M. (2018). Implementation of pharmacogenomics in the clinic. In EUROPEAN JOURNAL OF HUMAN GENETICS Vol. 26 (pp. 31). Retrieved from http://gateway.webofknowledge.com/

CAN GENOTYPING PREDICT RISK OF ALCOHOL-RELATED CIRRHOSIS IN HIGH-RISK DRINKERS? (Conference Paper)

Whitfield, J., Schwantes-An, T. -H., Cordell, H. J., Darlay, R., Masson, S., Liangpunsakul, S., . . . Seth, D. (2019). CAN GENOTYPING PREDICT RISK OF ALCOHOL-RELATED CIRRHOSIS IN HIGH-RISK DRINKERS?. In HEPATOLOGY Vol. 70 (pp. 171A-172A). Retrieved from http://gateway.webofknowledge.com/

Meta-analysis of inhaled corticosteroids response in children with asthma (Conference Paper)

Hernandez-Pacheco, N., Vijverberg, S. J., Gorenjak, M., Flores, C., Francis, B., Farzan, N., . . . Pino-Yanes, M. (2019). Meta-analysis of inhaled corticosteroids response in children with asthma. In EUROPEAN RESPIRATORY JOURNAL Vol. 54. doi:10.1183/13993003.congress-2019.PA5434

DOI: 10.1183/13993003.congress-2019.PA5434

Adaptation of host transmission cycle during Clostridium difficile speciation (Journal article)

Kumar, N., Browne, H. P., Viciani, E., Forster, S. C., Clare, S., Harcourt, K., . . . Lawley, T. D. (2019). Adaptation of host transmission cycle during Clostridium difficile speciation. NATURE GENETICS, 51(9), 1315-1320. doi:10.1038/s41588-019-0478-8

DOI: 10.1038/s41588-019-0478-8

Adverse drug reaction causality assessment tools for drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: room for improvement (vol 75, pg 1135, 2019) (Journal article)

Goldman, J. L., Chung, W. -H., Lee, B. R., Chen, C. -B., Lu, C. -W., Hoetzenecker, W., . . . Pirmohamed, M. (2019). Adverse drug reaction causality assessment tools for drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: room for improvement (vol 75, pg 1135, 2019). EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 75(9), 1331. doi:10.1007/s00228-019-02710-4

DOI: 10.1007/s00228-019-02710-4

Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials (Journal article)

Johnson, D., Hughes, D., Pirmohamed, M., & Jorgensen, A. (2019). Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials. JOURNAL OF PERSONALIZED MEDICINE, 9(3). doi:10.3390/jpm9030042

DOI: 10.3390/jpm9030042

Trends in BRCA testing and socioeconomic deprivation (Journal article)

Martin, A. P., Pedra, G., Downing, J., Collins, B., Godman, B., Alfirevic, A., . . . Greenhalgh, K. L. (2019). Trends in BRCA testing and socioeconomic deprivation. EUROPEAN JOURNAL OF HUMAN GENETICS, 27(9), 1351-1360. doi:10.1038/s41431-019-0424-3

DOI: 10.1038/s41431-019-0424-3

ADVERSE DRUG REACTION CAUSALITY ASSESSMENT TOOLS FOR DRUG-INDUCED STEVENS-JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS: ROOM FOR IMPROVEMENT. (Conference Paper)

Goldman, J. L., Chung, W. -H., Lee, B. R., Chen, C. -B., Lu, C. -W., Hoetzenecker, W., . . . Pirmohamed, M. (2019). Adverse drug reaction causality assessment tools for drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: room for improvement. In EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY Vol. 75 (pp. 1135-1141). doi:10.1007/s00228-019-02670-9

Drug-induced liver injury associated with Antituberculosis and/or antiretroviral therapy: A case series from a prospective registry in the Western cape, South Africa (Conference Paper)

Gunter, H. M., Allie, S., Stewart, A., Pirmohamed, M., & Cohen, K. (2019). Drug-induced liver injury associated with Antituberculosis and/or antiretroviral therapy: A case series from a prospective registry in the Western cape, South Africa. In PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol. 28 (pp. 576-577). Retrieved from http://gateway.webofknowledge.com/

Telmisartan to reduce insulin resistance in HIV-positive individuals on combination antiretroviral therapy: the TAILoR dose-ranging Phase II RCT (Journal article)

Pushpakom, S., Kolamunnage-Dona, R., Taylor, C., Foster, T., Spowart, C., Garcia-Finana, M., . . . Pirmohamed, M. (2019). Telmisartan to reduce insulin resistance in HIV-positive individuals on combination antiretroviral therapy: the TAILoR dose-ranging Phase II RCT.

Genetic testing for prevention of severe drug-induced skin rash. (Journal article)

Alfirevic, A., Pirmohamed, M., Marinovic, B., Harcourt-Smith, L., Jorgensen, A. L., & Cooper, T. E. (2019). Genetic testing for prevention of severe drug-induced skin rash.. The Cochrane Database of Systematic Reviews, 7, CD010891. doi:10.1002/14651858.cd010891.pub2

DOI: 10.1002/14651858.cd010891.pub2

Cutaneous toxicity from immune checkpoint inhibitors: experience from a specialist dermatology unit (Conference Paper)

Yip, V., Hindle, E., Olsson-Brown, A., & Pirmohamed, M. (2019). Cutaneous toxicity from immune checkpoint inhibitors: experience from a specialist dermatology unit. In BRITISH JOURNAL OF DERMATOLOGY Vol. 181 (pp. 136). Retrieved from http://gateway.webofknowledge.com/

Cutaneous toxicity from immune checkpoint inhibitors: experience from a specialist dermatology unit (Conference Paper)

Yip, V., Hindle, E., Olsson-Brown, A., & Pirmohamed, M. (2019). Cutaneous toxicity from immune checkpoint inhibitors: experience from a specialist dermatology unit. In BRITISH JOURNAL OF DERMATOLOGY Vol. 181 (pp. 69). Retrieved from http://gateway.webofknowledge.com/

Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles (Journal article)

Nicoletti, P., Aithal, G. P., Chamberlain, T. C., Coulthard, S., Alshabeeb, M., Grove, J. I., . . . Cons, I. D. -I. L. I. (2019). Drug-Induced Liver Injury due to Flucloxacillin: Relevance of Multiple Human Leukocyte Antigen Alleles. CLINICAL PHARMACOLOGY & THERAPEUTICS, 106(1), 245-253. doi:10.1002/cpt.1375

DOI: 10.1002/cpt.1375

HLA- and immune-mediated adverse drug reactions: Another hit with vancomycin (Journal article)

Pirmohamed, M. (2019). HLA- and immune-mediated adverse drug reactions: Another hit with vancomycin. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 144(1), 44-45. doi:10.1016/j.jaci.2019.04.009

DOI: 10.1016/j.jaci.2019.04.009

Nilotinib-induced metabolic dysfunction: insights from a translational study using in vitro adipocyte models and patient cohorts (Journal article)

Sadiq, S., Owen, E., Foster, T., Knight, K., Wang, L., Pirmohamed, M., . . . Pushpakom, S. (2019). Nilotinib-induced metabolic dysfunction: insights from a translational study using in vitro adipocyte models and patient cohorts. Leukemia, 33, 1810-1814. doi:10.1038/s41375-018-0337-0

DOI: 10.1038/s41375-018-0337-0

Serum and blister-fluid elevation and decreased epidermal content of high-mobility group box 1 protein in drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (Journal article)

Carr, D. F., Wang, C. -W., Bellon, T., Ressel, L., Nwikue, G., Shrivastava, V., . . . Pirmohamed, M. (2019). Serum and blister-fluid elevation and decreased epidermal content of high-mobility group box 1 protein in drug-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. BRITISH JOURNAL OF DERMATOLOGY, 181(1), 166-174. doi:10.1111/bjd.17610

DOI: 10.1111/bjd.17610

Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing. (Journal article)

Floyd, J. S., Bloch, K. M., Brody, J. A., Maroteau, C., Siddiqui, M. K., Gregory, R., . . . PREDICTION-ADR Consortium and EUDRAGENE. (2019). Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing.. PLoS One, 14(6). doi:10.1371/journal.pone.0218115

DOI: 10.1371/journal.pone.0218115

ALCOHOL RELATED BRAIN INJURY IN ALCOHOL USE DISORDER PATIENTS ATTENDING A UK SECONDARY CARE HOSPITAL (Conference Paper)

Richardson, P., Pirmohamed, M., Owens, L., & Thompson, A. (2019). ALCOHOL RELATED BRAIN INJURY IN ALCOHOL USE DISORDER PATIENTS ATTENDING A UK SECONDARY CARE HOSPITAL. In ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Vol. 43 (pp. 186A). Retrieved from http://gateway.webofknowledge.com/

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma (Journal article)

Hawcutt, D. B., & Pirmohamed, M. (2019). Genome-wide association study of inhaled corticosteroid response in admixed children with asthma. Clinical and Experimental Allergy, 49(6), 789-798. doi:10.1111/cea.13354

DOI: 10.1111/cea.13354

IDENTIFYING AND CONFIRMING THE FUNCTIONAL VALIDITY OF GENETIC LOCI IN ALCOHOL CONSUMPTION USING UK BIOBANK (Conference Paper)

Thompson, A., Cook, J. P., Kinnunen, T., Barclay, J., Morris, A. P., & Pirmohamed, M. (2019). IDENTIFYING AND CONFIRMING THE FUNCTIONAL VALIDITY OF GENETIC LOCI IN ALCOHOL CONSUMPTION USING UK BIOBANK. In ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Vol. 43 (pp. 203A). Retrieved from http://gateway.webofknowledge.com/

Cost-Effectiveness of Panel Tests for Multiple Pharmacogenes Associated With Adverse Drug Reactions: An Evaluation Framework (Journal article)

Plumpton, C. O., Pirmohamed, M., & Hughes, D. A. (2019). Cost-Effectiveness of Panel Tests for Multiple Pharmacogenes Associated With Adverse Drug Reactions: An Evaluation Framework. Clinical pharmacology and therapeutics, 105(6), 1429-1438. doi:10.1002/cpt.1312

DOI: 10.1002/cpt.1312

The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose: A single patient data meta-analysis in more than 15,000 individuals (Journal article)

Danese, E., Raimondi, S., Montagnana, M., Tagetti, A., Langaee, T., Borgiani, P., . . . Fava, C. (2019). The effect of CYP4F2, VKORC1 and CYP2C9 in influencing coumarin dose: A single patient data meta-analysis in more than 15,000 individuals. Clinical pharmacology and therapeutics, 105(6), 1477-1491. doi:10.1002/cpt.1323

DOI: 10.1002/cpt.1323

Shared genetic risk factors across carbamazepine-induced hypersensitivity reactions. (Journal article)

Nicoletti, P., Barrett, S., McEvoy, L., Daly, A. K., Aithal, G., Lucena, M. I., . . . Pirmohamed, M. (2019). Shared genetic risk factors across carbamazepine-induced hypersensitivity reactions.. Clinical pharmacology and therapeutics, 106(5), 1028-1036. doi:10.1002/cpt.1493

DOI: 10.1002/cpt.1493

Trends in BRCA testing over time and socioeconomic deprivation (Journal article)

Martin, A. P., Pedra, G., Downing, J., Collins, B., Godman, B., Alfirevic, A., . . . Greenhalgh, K. L. (n.d.). Trends in BRCA testing over time and socioeconomic deprivation. European Journal of Human Genetics. doi:10.1038/s41431-019-0424-3

DOI: 10.1038/s41431-019-0424-3

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury (Journal article)

Cirulli, E. T., Nicoletti, P., Abramson, K., Andrade, R. J., Bjornsson, E. S., Chalasani, N., . . . iDILIC, I. D. I. L. I. C. (2019). A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury. Gastroenterology, 156(6), 1707-1716. doi:10.1053/j.gastro.2019.01.034

DOI: 10.1053/j.gastro.2019.01.034

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy (Retraction of Vol 127, Pg 2118, 2017) (Journal article)

Walker, L. E., Frigerio, F., Ravizza, T., Ricci, E., Tse, K., Jenkins, R. E., . . . Pirmohamed, M. (2019). Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy (Retraction of Vol 127, Pg 2118, 2017). JOURNAL OF CLINICAL INVESTIGATION, 129(5), 2166. doi:10.1172/JCI129285

DOI: 10.1172/JCI129285

Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study (Journal article)

Jorgensen, A. L., Prince, C., Fitzgerald, G., Hanson, A., Downing, J., Reynolds, J., . . . Pirmohamed, M. (2019). Implementation of genotype-guided dosing of warfarin with point-of-care genetic testing in three UK clinics: a matched cohort study. BMC Medicine, 17. doi:10.1186/s12916-019-1308-7

DOI: 10.1186/s12916-019-1308-7

Precision Medicine (Conference Paper)

Pirmohamed, M. (2019). Precision Medicine. In JOURNAL OF PATHOLOGY Vol. 248 (pp. S4). Retrieved from http://gateway.webofknowledge.com/

Working together to deliver stratified medicine research effectively (Journal article)

Attar, S. G., Poustie, V. J., Hawcutt, D. B., Oni, L., Beresford, M. W., & Pirmohamed, M. (2019). Working together to deliver stratified medicine research effectively. British Medical Bulletin. doi:10.1093/bmb/ldz003

DOI: 10.1093/bmb/ldz003

Nonmedical prescriber experiences of training and competence to report adverse drug reactions in the UK (Conference Paper)

Thompson, A., Randall, C., Howard, J., Barker, C., Bowden, D., Mooney, P., . . . Pirmohamed, M. (2019). Nonmedical prescriber experiences of training and competence to report adverse drug reactions in the UK. In JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS Vol. 44 (pp. 78-83). doi:10.1111/jcpt.12756

DOI: 10.1111/jcpt.12756

Software for Dosage Individualization of Voriconazole: a Prospective Clinical Study. (Journal article)

Hope, W., Johnstone, G., Cicconi, S., Felton, T., Goodwin, J., Whalley, S., . . . Neely, M. (2019). Software for Dosage Individualization of Voriconazole: a Prospective Clinical Study.. Antimicrobial agents and chemotherapy. doi:10.1128/aac.02353-18

DOI: 10.1128/aac.02353-18

What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England (Journal article)

Giebel, C., McIntyre, J. C., Daras, K., Gabbay, M., Downing, J., Pirmohamed, M., . . . Barr, B. (2019). What are the social predictors of accident and emergency attendance in disadvantaged neighbourhoods? Results from a cross-sectional household health survey in the north west of England. BMJ Open, 9(1). doi:10.1136/bmjopen-2018-022820

DOI: 10.1136/bmjopen-2018-022820

A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis (Journal article)

Foulkes, A. C., Watson, D. S., Carr, D. F., Kenny, J. G., Slidel, T., Parslew, R., . . . Consortium, P. S. O. R. T. (2019). A Framework for Multi-Omic Prediction of Treatment Response to Biologic Therapy for Psoriasis. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 139(1), 100-107. doi:10.1016/j.jid.2018.04.041

DOI: 10.1016/j.jid.2018.04.041

Controversies in drug allergy: Testing for delayed reactions (Journal article)

Phillips, E. J., Bigliardi, P., Bircher, A. J., Broyles, A., Chang, Y. -S., Chung, W. -H., . . . Barbaud, A. (2019). Controversies in drug allergy: Testing for delayed reactions. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 143(1), 66-73. doi:10.1016/j.jaci.2018.10.030

DOI: 10.1016/j.jaci.2018.10.030

HLA-DQB1 6672G > C INFLUENCES THE RISK OF CLOZAPINE-INDUCED AGRANULOCYTOSIS IN INDIVIDUALS OF EUROPEAN ANCESTRY (Conference Paper)

Konte, B., Walters, J., Giegling, I., Legge, S., Cohen, D., Pirmohamed, M., . . . Rujescu, D. (2019). HLA-DQB1 6672G > C INFLUENCES THE RISK OF CLOZAPINE-INDUCED AGRANULOCYTOSIS IN INDIVIDUALS OF EUROPEAN ANCESTRY. In EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 29 (pp. S866). doi:10.1016/j.euroneuro.2017.08.154

DOI: 10.1016/j.euroneuro.2017.08.154

META-ANALYSIS OF CLOZAPINE-ASSOCIATED NEUTROPENIA AND AGRANULOCYTOSIS (Conference Paper)

Konte, B., Walters, J. T., Giegling, I., Legge, S., Pardinas, A. F., Cohen, D., . . . Rujescu, D. (2019). META-ANALYSIS OF CLOZAPINE-ASSOCIATED NEUTROPENIA AND AGRANULOCYTOSIS. In EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 29 (pp. 1320-1321). doi:10.1016/j.euroneuro.2018.08.466

DOI: 10.1016/j.euroneuro.2018.08.466

Processes and barriers to implementation of point-of-care genotype-guided dosing of warfarin into UK outpatient anticoagulation clinics (Journal article)

Fitzgerald, G., Prince, C., Downing, J., Reynolds, J., Zhang, J. E., Hanson, A., . . . Pirmohamed, M. (2019). Processes and barriers to implementation of point-of-care genotype-guided dosing of warfarin into UK outpatient anticoagulation clinics. PHARMACOGENOMICS, 20(8), 599-608. doi:10.2217/pgs-2019-0021

DOI: 10.2217/pgs-2019-0021

REPLICATION OF TWO INDEPENDENT LOCI IN HLA-DQB1 AND HLA-B CONTRIBUTING TO THE RISK OF CLOZAPINE-INDUCED AGRANULOCYTOSIS (Conference Paper)

Konte, B., Giegling, I., Legge, S., Cohen, D., Pirmohamed, M., Tiihonen, J., . . . Rujescu, D. (2019). REPLICATION OF TWO INDEPENDENT LOCI IN HLA-DQB1 AND HLA-B CONTRIBUTING TO THE RISK OF CLOZAPINE-INDUCED AGRANULOCYTOSIS. In EUROPEAN NEUROPSYCHOPHARMACOLOGY Vol. 29 (pp. S939). doi:10.1016/j.euroneuro.2017.08.282

DOI: 10.1016/j.euroneuro.2017.08.282

2018

Drug repurposing: progress, challenges and recommendations (Journal article)

Pushpakom, S., Iorio, F., Eyers, P. A., Escott, K. J., Hopper, S., Wells, A., . . . Pirmohamed, M. (2019). Drug repurposing: progress, challenges and recommendations. NATURE REVIEWS DRUG DISCOVERY, 18(1), 41-58. doi:10.1038/nrd.2018.168

DOI: 10.1038/nrd.2018.168

Applying personalised medicine in clinical practice (Conference Paper)

Pirmohamed, M. (2018). Applying personalised medicine in clinical practice. In POSTGRADUATE MEDICAL JOURNAL Vol. 94 (pp. A4). doi:10.1136/postgradmedj-2018-fpm.9

DOI: 10.1136/postgradmedj-2018-fpm.9

Effects of Common Antiepileptic Drugs on Biomarkers of Oxidative Stress in a Human Neuroblastoma Cell Line (Conference Paper)

Al-Mosawi, R., Marson, A., Pirmohamed, M., & Sills, G. (2018). Effects of Common Antiepileptic Drugs on Biomarkers of Oxidative Stress in a Human Neuroblastoma Cell Line. In EPILEPSIA Vol. 59 (pp. S39). Retrieved from http://gateway.webofknowledge.com/

The Prescribable Drugs with Efficacy in Experimental Epilepsies (PDE3) Database for Drug Repurposing Research in Epilepsy (Conference Paper)

Sivapalarajah, S., Krishnakumar, M., Bickerstaffe, H., Chan, Y., Clarkson, J., Hampden-Martin, A., . . . Mirza, N. (2018). The Prescribable Drugs with Efficacy in Experimental Epilepsies (PDE3) Database for Drug Repurposing Research in Epilepsy. In EPILEPSIA Vol. 59 (pp. S70-S71). Retrieved from http://gateway.webofknowledge.com/

The unexpected challenges of immunotherapy (Conference Paper)

Olsson-Brown, A. C., Guinan, T. J., Mckay, M., Chow, S., Lord, R., Pirmohamed, M., & Sacco, J. J. (2018). The unexpected challenges of immunotherapy. In ANNALS OF ONCOLOGY Vol. 29 (pp. 20). Retrieved from http://gateway.webofknowledge.com/

Exploring oxidative stress pathways in epilepsy (Thesis / Dissertation)

Al-Mosawi, R. H. (2018, October 24). Exploring oxidative stress pathways in epilepsy.

MECHANISMS OF CHEMOTHERAPY-INDUCED DIARRHOEA (Conference Paper)

French, S., Davies, A., & Pirmohamed, M. (2018). MECHANISMS OF CHEMOTHERAPY-INDUCED DIARRHOEA. In GUT Vol. 67 (pp. A159). doi:10.1136/gutjnl-2018-BSGAbstracts.315

DOI: 10.1136/gutjnl-2018-BSGAbstracts.315

17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use (Journal article)

Farzan, N., Vijverberg, S. J., Hernandez-Pacheco, N., Bel, E. H. D., Berce, V., Bonnelykke, K., . . . Maitland-van der Zee, A. -H. (2018). 17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use. ALLERGY, 73(10), 2083-2088. doi:10.1111/all.13499

DOI: 10.1111/all.13499

Identification of a PTPN22 Missense Variant As a General Genetic Risk Factor for Drug-Induced Liver Injury (Conference Paper)

Watkins, P. B., Nicoletti, P., Cirulli, E., Abramson, K., Andrade, R. J., Bjornsson, E., . . . Aithal, G. P. (2018). Identification of a PTPN22 Missense Variant As a General Genetic Risk Factor for Drug-Induced Liver Injury. In HEPATOLOGY Vol. 68 (pp. 25A). Retrieved from http://gateway.webofknowledge.com/

Identification of a novel locus associated with asthma treatment response with inhaled corticosteroids in African-admixed children (Conference Paper)

Hernandez-Pacheco, N., Farzan, N., Vijverberg, S., Francis, B., Schieck, M., Pirmohamed, M., . . . Consortia, P. S. (2018). Identification of a novel locus associated with asthma treatment response with inhaled corticosteroids in African-admixed children. In EUROPEAN JOURNAL OF HUMAN GENETICS Vol. 26 (pp. 693-694). Retrieved from http://gateway.webofknowledge.com/

Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies (Journal article)

Martin, A. P., Downing, J., Cochrane, M., Collins, B., Francis, B., Haycox, A., . . . Pirmohamed, M. (2018). Trastuzumab uptake in HER2-positive breast cancer patients: a systematic review and meta-analysis of observational studies. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 130, 92-107. doi:10.1016/j.critrevonc.2018.07.012

DOI: 10.1016/j.critrevonc.2018.07.012

Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort. (Journal article)

Turner, R. M., Fontana, V., Bayliss, M., Whalley, S., Castelazo, A. S., & Pirmohamed, M. (2018). Development, validation and application of a novel HPLC-MS/MS method for the quantification of atorvastatin, bisoprolol and clopidogrel in a large cardiovascular patient cohort. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 159, 272-281. doi:10.1016/j.jpba.2018.06.062

DOI: 10.1016/j.jpba.2018.06.062

Identifying cisplatin-induced kidney damage in paediatric oncology patients (Journal article)

Barton, C. D., Pizer, B., Jones, C., Oni, L., Pirmohamed, M., & Hawcutt, D. B. (2018). Identifying cisplatin-induced kidney damage in paediatric oncology patients. PEDIATRIC NEPHROLOGY, 33(9), 1467-1474. doi:10.1007/s00467-017-3765-6

DOI: 10.1007/s00467-017-3765-6

Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process (Journal article)

Dickens, D., Rädisch, S., Chiduza, G. N., Giannoudis, A., Cross, M. J., Malik, H., . . . Nies, A. T. (2018). Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process. Molecular Pharmaceutics, 15(8), 3557-3572. doi:10.1021/acs.molpharmaceut.8b00547

DOI: 10.1021/acs.molpharmaceut.8b00547

Genetic and nongenetic factors that may predispose individuals to allergic drug reactions (Journal article)

Gibson, A., Ogese, M., & Pirmohamed, M. (2018). Genetic and nongenetic factors that may predispose individuals to allergic drug reactions. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 18(4), 325-332. doi:10.1097/ACI.0000000000000459

DOI: 10.1097/ACI.0000000000000459

Warfarin: The End or the End of One Size Fits All Therapy? (Journal article)

Pirmohamed, M. (2018). Warfarin: The End or the End of One Size Fits All Therapy?. JOURNAL OF PERSONALIZED MEDICINE, 8(3). doi:10.3390/jpm8030022

DOI: 10.3390/jpm8030022

New uses for old drugs (Journal article)

Pantziarka, P., Pirmohamed, M., & Mirza, N. (2018). New uses for old drugs. BMJ-BRITISH MEDICAL JOURNAL, 361. doi:10.1136/bmj.k2701

DOI: 10.1136/bmj.k2701

Adrenal suppression with inhaled corticosteroids: the seed and the soil reply (Journal article)

Hawcutt, D. B., Francis, B., & Pirmohamed, M. (2018). Adrenal suppression with inhaled corticosteroids: the seed and the soil reply. LANCET RESPIRATORY MEDICINE, 6(6), E20. doi:10.1016/S2213-2600(18)30149-8

DOI: 10.1016/S2213-2600(18)30149-8

Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study (Journal article)

Hawcutt, D. B., Francis, B., Carr, D., Jorgensen, A. L., Yin, P., Wallin, N., . . . Pirmohamed, M. (2018). Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study. The Lancet Respiratory Medicine, 6(6), 442-450. doi:10.1016/S2213-2600(18)30058-4

DOI: 10.1016/S2213-2600(18)30058-4

Causality Patterns for Detecting Adverse Drug Reactions From Social Media: Text Mining Approach (Journal article)

Bollegala, D., Maskell, S., Sloane, R., Hajne, J., & Pirmohamed, M. (2018). Causality Patterns for Detecting Adverse Drug Reactions From Social Media: Text Mining Approach. JMIR PUBLIC HEALTH AND SURVEILLANCE, 4(2), 292-303. doi:10.2196/publichealth.8214

DOI: 10.2196/publichealth.8214

Causality Patterns for Detecting Adverse Drug Reactions From Social Media: Text Mining Approach (Preprint) (Journal article)

Bollegala, D., Maskell, S., Sloane, R., Hajne, J., & Pirmohamed, M. (n.d.). Causality Patterns for Detecting Adverse Drug Reactions From Social Media: Text Mining Approach (Preprint). doi:10.2196/preprints.8214

DOI: 10.2196/preprints.8214

TEMPORARY REMOVAL: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers. (Journal article)

Francis, B., Clarke, J. I., Walker, L. E., Brillant, N., Jorgensen, A. L., Park, B. K., . . . Antoine, D. J. (2018). TEMPORARY REMOVAL: Reference intervals for putative biomarkers of drug-induced liver injury and liver regeneration in healthy human volunteers. . Journal of hepatology, S0168-8278(18)32042-7. doi:10.1016/j.jhep.2018.04.024

DOI: 10.1016/j.jhep.2018.04.024

TRASTUZUMAB UPTAKE IN HER2-POSITIVE BREAST CANCER PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF OBSERVATIONAL STUDIES (Conference Paper)

Martin, A. P., Downing, J., Collins, B., Cochrane, M., Francis, B., Haycox, A., . . . Pirmohamed, M. (2018). TRASTUZUMAB UPTAKE IN HER2-POSITIVE BREAST CANCER PATIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF OBSERVATIONAL STUDIES. In VALUE IN HEALTH Vol. 21 (pp. S43). doi:10.1016/j.jval.2018.04.248

DOI: 10.1016/j.jval.2018.04.248

Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro. (Journal article)

Pushpakom, S. P., Adaikalakoteswari, A., Owen, A., Back, D. J., Tripathi, G., Kumar, S., . . . Pirmohamed, M. (2018). Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro.. Diabetes & vascular disease research, 15(3), 233-242. doi:10.1177/1479164118757924

DOI: 10.1177/1479164118757924

The need for patient-tailored dosing of baclofen in future clinical trials Response (Journal article)

Thompson, A., Pirmohamed, M., Owens, L., & Richardson, P. (2018). The need for patient-tailored dosing of baclofen in future clinical trials Response. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 28(5), 658. doi:10.1016/j.euroneuro.2018.03.002

DOI: 10.1016/j.euroneuro.2018.03.002

Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update (Journal article)

Phillips, E. J., Sukasem, C., Whirl-Carrillo, M., Mueller, D. J., Dunnenberger, H. M., Chantratita, W., . . . Pirmohamed, M. (2018). Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update. CLINICAL PHARMACOLOGY & THERAPEUTICS, 103(4), 574-581. doi:10.1002/cpt.1004

DOI: 10.1002/cpt.1004

Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin (Journal article)

McWilliam, S. J., Antoine, D. J., Jorgensen, A. L., Smyth, R. L., & Pirmohamed, M. (2018). Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin. Scientific Reports, 8. doi:10.1038/s41598-018-23466-4

DOI: 10.1038/s41598-018-23466-4

Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity (Journal article)

Usui, T., Faulkner, L., Farrell, J., French, N. S., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. J. (2018). Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity. CHEMICAL RESEARCH IN TOXICOLOGY, 31(3), 165-167. doi:10.1021/acs.chemrestox.8b00030

DOI: 10.1021/acs.chemrestox.8b00030

IMPLEMENTING PRE-EMPTIVE PHARMACOGENOMIC TESTING FOR A PANEL OF PHARMACOGENES IN THE PREPARE STUDY (U-PGx CONSORTIUM): RESULTS FROM THE FIRST 1,000 PATIENTS. (Conference Paper)

van der Wouden, C. H., Davila-Fajardo, C., Dolzan, V., Patrinos, G. P., Pirmohamed, M., Sunder-Plassmann, G., . . . Guchelaar, H. -J. (2018). IMPLEMENTING PRE-EMPTIVE PHARMACOGENOMIC TESTING FOR A PANEL OF PHARMACOGENES IN THE PREPARE STUDY (U-PGx CONSORTIUM): RESULTS FROM THE FIRST 1,000 PATIENTS.. In CLINICAL PHARMACOLOGY & THERAPEUTICS Vol. 103 (pp. S13). Retrieved from http://gateway.webofknowledge.com/

Repurposing Statins for Renal Protection: Is It a Class Effect? (Journal article)

McWilliam, S. J., Antoine, D. J., & Pirmohamed, M. (2018). Repurposing Statins for Renal Protection: Is It a Class Effect?. CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 11(2), 100-102. doi:10.1111/cts.12521

DOI: 10.1111/cts.12521

Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis (Journal article)

Manolio, T. A., Hutter, C. M., Avigan, M., Cibotti, R., Davis, R. L., Denny, J. C., . . . Shear, N. H. (2018). Research Directions in Genetic Predispositions to Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis. CLINICAL PHARMACOLOGY & THERAPEUTICS, 103(3), 390-394. doi:10.1002/cpt.890

DOI: 10.1002/cpt.890

The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017) (Journal article)

Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2018). The effect of inhibitory signals on the priming of drug hapten-specific T cells that express distinct V beta receptors (vol 199, pg 1223, 2017). JOURNAL OF IMMUNOLOGY, 200(5), 1951. doi:10.4049/jimmunol.1800019

DOI: 10.4049/jimmunol.1800019

Zoonotic Transfer of Clostridium difficile Harboring Antimicrobial Resistance between Farm Animals and Humans (Journal article)

Knetsch, C. W., Kumar, N., Forster, S. C., Connor, T. R., Browne, H. P., Harmanus, C., . . . Lawley, T. D. (2018). Zoonotic Transfer of Clostridium difficile Harboring Antimicrobial Resistance between Farm Animals and Humans. JOURNAL OF CLINICAL MICROBIOLOGY, 56(3). doi:10.1128/JCM.01384-17

DOI: 10.1128/JCM.01384-17

Two distinct clinical trajectories of inflammatory thyroiditis evoked by checkpoint blockade in malignant melanoma. (Conference Paper)

Olsson-Brown, A. C., Lord, R., Sacco, J. J., Coles, M. C., Wagg, J., & Pirmohamed, M. (2018). Two distinct clinical trajectories of inflammatory thyroiditis evoked by checkpoint blockade in malignant melanoma.. In JOURNAL OF CLINICAL ONCOLOGY Vol. 36. doi:10.1200/JCO.2018.36.5_suppl.131

DOI: 10.1200/JCO.2018.36.5_suppl.131

Biomarkers of adverse drug reactions (Journal article)

Carr, D. F., & Pirmohamed, M. (2018). Biomarkers of adverse drug reactions. EXPERIMENTAL BIOLOGY AND MEDICINE, 243(3), 291-299. doi:10.1177/1535370217733425

DOI: 10.1177/1535370217733425

Direct oral anticoagulants versus warfarin: is new always better than the old? (Journal article)

Burn, J., & Pirmohamed, M. (2018). Direct oral anticoagulants versus warfarin: is new always better than the old?. Open heart, 5(1), e000712. doi:10.1136/openhrt-2017-000712

DOI: 10.1136/openhrt-2017-000712

Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis (Journal article)

Whitfield, J. B., Masson, S., Liangpunsakul, S., Hyman, J., Mueller, S., Aithal, G., . . . Consortium, G. (2018). Evaluation of laboratory tests for cirrhosis and for alcohol use, in the context of alcoholic cirrhosis. ALCOHOL, 66, 1-7. doi:10.1016/j.alcohol.2017.07.006

DOI: 10.1016/j.alcohol.2017.07.006

Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies (Journal article)

Dear, J. W., Clarke, J. I., Francis, B., Allen, L., Wraight, J., Shen, J., . . . Antoine, D. J. (2018). Risk stratification after paracetamol overdose using mechanistic biomarkers: results from two prospective cohort studies. The Lancet Gastroenterology and Hepatology, 3(2), 104-113. doi:10.1016/S2468-1253(17)30266-2

DOI: 10.1016/S2468-1253(17)30266-2

The prescribable drugs with efficacy in experimental epilepsies (PDE3) database for drug repurposing research in epilepsy (Journal article)

Sivapalarajah, S., Krishnakumar, M., Bickerstaffe, H., Chan, Y., Clarkson, J., Hampden-Martin, A., . . . Mirza, N. (2018). The prescribable drugs with efficacy in experimental epilepsies (PDE3) database for drug repurposing research in epilepsy. Epilepsia, 59(2), 492-501. doi:10.1111/epi.13994

DOI: 10.1111/epi.13994

A Genome-Wide Association Study of Methotrexate-Pneumonitis in Rheumatoid Arthritis: Results from the Pneumonitis Study Consortium (Conference Paper)

Bluett, J., Owen, S. -A., Massey, J., Plant, D., Pirmohamed, M., Verstappen, S. M. M., & Barton, A. (2018). A Genome-Wide Association Study of Methotrexate-Pneumonitis in Rheumatoid Arthritis: Results from the Pneumonitis Study Consortium. In ARTHRITIS & RHEUMATOLOGY Vol. 68. Retrieved from http://gateway.webofknowledge.com/

Nucleic acid based therapies: developing frontier for precision medicine (Journal article)

Pirmohamed, M. (2018). Nucleic acid based therapies: developing frontier for precision medicine. BMJ-BRITISH MEDICAL JOURNAL, 360. doi:10.1136/bmj.k223

DOI: 10.1136/bmj.k223

Pharmacogenetics and Pharmacogenomics in Cardiovascular Medicine and Surgery (Chapter)

Turner, R. M., & Pirmohamed, S. M. (2018). Pharmacogenetics and Pharmacogenomics in Cardiovascular Medicine and Surgery. In Cardiovascular Genetics and Genomics (pp. 119-172). Springer International Publishing. doi:10.1007/978-3-319-66114-8_5

DOI: 10.1007/978-3-319-66114-8_5

Pharmacogenetics of Adverse Drug Reactions. (Chapter)

Osanlou, O., Pirmohamed, M., & Daly, A. K. (2018). Pharmacogenetics of Adverse Drug Reactions.. In Unknown Book (Vol. 83, pp. 155-190). doi:10.1016/bs.apha.2018.03.002

DOI: 10.1016/bs.apha.2018.03.002

Renal function monitoring in heart failure - what is the optimal frequency? A narrative review (Journal article)

Al-Naher, A., Wright, D., Devonald, M. A. J., & Pirmohamed, M. (2018). Renal function monitoring in heart failure - what is the optimal frequency? A narrative review. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 84(1), 5-17. doi:10.1111/bcp.13434

DOI: 10.1111/bcp.13434

SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation (Journal article)

White, K. D., Abe, R., Ardern-Jones, M., Beachkofsky, T., Bouchard, C., Carleton, B., . . . Phillips, E. J. (2018). SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 6(1), 38-69. doi:10.1016/j.jaip.2017.11.023

DOI: 10.1016/j.jaip.2017.11.023

2017

Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients (Journal article)

McCormack, M., Gui, H., Ingason, A., Speed, D., Wright, G. E. B., Zhang, E. J., . . . Rau, S. (2017). Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients. Neurology, 90(4). doi:10.1212/WNL.0000000000004853

DOI: 10.1212/WNL.0000000000004853

A common missense variant of LILRB5 is associated with statin intolerance and myalgia. (Journal article)

Siddiqui, M. K., Maroteau, C., Veluchamy, A., Tornio, A., Tavendale, R., Carr, F., . . . Consortium, P. R. E. D. I. C. T. I. O. N. -A. D. R. (2017). A common missense variant of LILRB5 is associated with statin intolerance and myalgia. EUROPEAN HEART JOURNAL, 38(48), 3569-3U31. doi:10.1093/eurheartj/ehx467

DOI: 10.1093/eurheartj/ehx467

HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study. (Journal article)

Bluett, J., Owen, S. -A., Massey, J., Alfirevic, A., Pirmohamed, M., Plant, D., . . . Consortium, P. S. (2017). HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome-wide association study. ANNALS OF THE RHEUMATIC DISEASES, 76(12). doi:10.1136/annrheumdis-2017-211512

DOI: 10.1136/annrheumdis-2017-211512

How important is aspirin adherence when evaluating effectiveness of low-dose aspirin? (Journal article)

Navaratnam, K., Alfirevic, Z., Pirmohamed, M., & Alfirevic, A. (2017). How important is aspirin adherence when evaluating effectiveness of low-dose aspirin?. EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 219, 1-9. doi:10.1016/j.ejogrb.2017.10.004

DOI: 10.1016/j.ejogrb.2017.10.004

The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis (Journal article)

Cliff, J., Jorgensen, A. L., Lord, R., Azam, F., Cossar, L., Carr, D. F., & Pirmohamed, M. (2017). The molecular genetics of chemotherapy-induced peripheral neuropathy: A systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 120, 127-140. doi:10.1016/j.critrevonc.2017.09.009

DOI: 10.1016/j.critrevonc.2017.09.009

Genome-Wide Association Study Links Variants With Occurrence of Cardiovascular Events in People Taking the COX-2 Inhibitor Celecoxib: Identification of NCKX2 as a Novel Protective Pathway in Renal Vessels (Conference Paper)

Kirkby, N. S., Morris, A. P., Lytton, J., Seong, J. K., Bae, Y. S., Chu, J. H., . . . Mitchell, J. A. (2017). Genome-Wide Association Study Links Variants With Occurrence of Cardiovascular Events in People Taking the COX-2 Inhibitor Celecoxib: Identification of NCKX2 as a Novel Protective Pathway in Renal Vessels. In CIRCULATION Vol. 136. Retrieved from http://gateway.webofknowledge.com/

An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review (Journal article)

Martin, A., Downing, J., Maden, M., Fleeman, N., Alfirevic, A., Haycox, A., & Pirmohamed, M. (2017). An assessment of the impact of pharmacogenomics on health disparities: a systematic literature review. PHARMACOGENOMICS, 18(16), 1541-1550. doi:10.2217/pgs-2017-0076

DOI: 10.2217/pgs-2017-0076

Aminoglycoside-induced nephrotoxicity in children (Journal article)

McWilliam, S. J., Antoine, D. J., Smyth, R. L., & Pirmohamed, M. (2017). Aminoglycoside-induced nephrotoxicity in children. Pediatric Nephrology, 32(11), 2015-2025. doi:10.1007/s00467-016-3533-z

DOI: 10.1007/s00467-016-3533-z

Systematic review: Baclofen dosing protocols for alcohol use disorders used in observational studies (Journal article)

Thompson, A., Owens, L., Richardson, P., & Pirmohamed, M. (2017). Systematic review: Baclofen dosing protocols for alcohol use disorders used in observational studies. EUROPEAN NEUROPSYCHOPHARMACOLOGY, 27(11), 1077-1089. doi:10.1016/j.euroneuro.2017.08.434

DOI: 10.1016/j.euroneuro.2017.08.434

Checkpoint Inhibitor induced thyroid immune related adverse events: two distinct clinical patterns (Conference Paper)

Olsson-Brown, A., Lord, R., Sacco, J., Upton, J., Coles, M., & Pirmohamed, M. (2017). Checkpoint Inhibitor induced thyroid immune related adverse events: two distinct clinical patterns. In DRUG SAFETY Vol. 40 (pp. 1034). Retrieved from http://gateway.webofknowledge.com/

Mechanisms of Chemotherapy-Induced Diarrhoea (Conference Paper)

French, S., Davies, A., & Pirmohamed, M. (2017). Mechanisms of Chemotherapy-Induced Diarrhoea. In DRUG SAFETY Vol. 40 (pp. 1025-1026). Retrieved from http://gateway.webofknowledge.com/

Beyond co-occurrence-based ADR detection from Social Media (Poster)

Bollegala, D., Maskell, S., & Pirmohamed, M. (2017). Beyond co-occurrence-based ADR detection from Social Media. Poster session presented at the meeting of Unknown Conference. Retrieved from http://gateway.webofknowledge.com/

Whole exome sequencing in individuals with statin-induced myopathy (Conference Paper)

Bloch, K. M., Carr, D., Pirmohamed, M., Morris, A., Maroteau, C., Eriksson, N., . . . Alfirevic, A. (2017). Whole exome sequencing in individuals with statin-induced myopathy. In DRUG SAFETY Vol. 40 (pp. 1026). Retrieved from http://gateway.webofknowledge.com/

COST-EFFECTIVENESS OF A MULTI -GENE PANEL IN THE CONTEXT OF REDUCING ADVERSE DRUG REACTIONS (Conference Paper)

Plumpton, C. O., Pirmohamed, M., & Hughes, D. A. (2017). COST-EFFECTIVENESS OF A MULTI -GENE PANEL IN THE CONTEXT OF REDUCING ADVERSE DRUG REACTIONS. In VALUE IN HEALTH Vol. 20 (pp. A753). doi:10.1016/j.jval.2017.08.2111

Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout (Journal article)

Plumpton, C. O., Alfirevic, A., Pirmohamed, M., & Hughes, D. A. (2017). Cost effectiveness analysis of HLA-B*58:01 genotyping prior to initiation of allopurinol for gout. Rheumatology (Oxford, England), 56(10), 1729-1739. doi:10.1093/rheumatology/kex253

DOI: 10.1093/rheumatology/kex253

Estimating the Pertinent Information Present in Social Media, not just what an Algorithm Detects (Poster)

Maskell, S., Sloane, R., Perkins, S., Heap, J., Hajne, J., Jones, A., & Pirmohamed, M. (2017). Estimating the Pertinent Information Present in Social Media, not just what an Algorithm Detects. Poster session presented at the meeting of Unknown Conference. Retrieved from http://gateway.webofknowledge.com/

Looking Longitudinally in Twitter: Reading More than 140 Characters (Poster)

Maskell, S., Sloane, R., Hajne, J., Heap, J., Perkins, S., Griffith, E., . . . Pirmohamed, M. (2017). Looking Longitudinally in Twitter: Reading More than 140 Characters. Poster session presented at the meeting of Unknown Conference. Retrieved from http://gateway.webofknowledge.com/

Multiple HLA B*57 alleles, sharing the amino acid residue Valine(97), are associated with drug-induced liver injury due to flucloxacillin in a European population. (Conference Paper)

Nicoletti, P., Aithal, G. P., Coulthard, S., Andrade, R., Einar, B. S., Dillon, J., . . . Daly, A. K. (2017). Multiple HLA B*57 alleles, sharing the amino acid residue Valine(97), are associated with drug-induced liver injury due to flucloxacillin in a European population.. In HEPATOLOGY Vol. 66 (pp. 25A-26A). Retrieved from http://gateway.webofknowledge.com/

Pharmacogenomics: an overview (Journal article)

Pharmacogenomics: an overview (2017). Clinical Pharmacist. doi:10.1211/cp.2017.20203640

DOI: 10.1211/cp.2017.20203640

Preventing aminoglycoside-induced nephrotoxicity using statins: an example of bench-to-bedside research (Conference Paper)

McWilliam, S. J., Antoine, D., Smyth, R., & Pirmohamed, M. (2017). Preventing aminoglycoside-induced nephrotoxicity using statins: an example of bench-to-bedside research. In Archives of Disease in Childhood Vol. 102 (pp. A12). Leuven: BMJ. Retrieved from https://adc.bmj.com/content/102/10/A17.2

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update. (Journal article)

Johnson, J. A., Caudle, K. E., Gong, L., Whirl-Carrillo, M., Stein, C. M., Scott, S. A., . . . Wadelius, M. (2017). Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing: 2017 Update. CLINICAL PHARMACOLOGY & THERAPEUTICS, 102(3), 397-404. doi:10.1002/cpt.668

DOI: 10.1002/cpt.668

Genome-wide association study of asthma exacerbations in European children treated with inhaled corticosteroids (Conference Paper)

Vijverberg, S. J. H., Hernandez-Pacheco, N., Farzan, N., Francis, B., Flores, C., Schieck, M., . . . Maitland-Van der Zee, A. -H. (2017). Genome-wide association study of asthma exacerbations in European children treated with inhaled corticosteroids. In EUROPEAN RESPIRATORY JOURNAL Vol. 50. doi:10.1183/1393003.congress-2017.PA1817

DOI: 10.1183/1393003.congress-2017.PA1817

Genome-wide association study of inhaled corticosteroid response in African-admixed children with asthma (Conference Paper)

Hernandez-Pacheco, N., Farzan, N., Vijverberg, S. J., Francis, B., Schieck, M., Pirmohamed, M., . . . Pino-Yanes, M. (2017). Genome-wide association study of inhaled corticosteroid response in African-admixed children with asthma. In EUROPEAN RESPIRATORY JOURNAL Vol. 50. doi:10.1183/1393003.congress-2017.PA4688

DOI: 10.1183/1393003.congress-2017.PA4688

THE PROTEKT STUDY - A PHASE IIA, RANDOMISED, CONTROLLED, OPEN-LABEL TRIAL OF ROSUVASTATIN FOR THE PREVENTION OF AMINOGLYCOSIDE-INDUCED KIDNEY TOXICITY IN CHILDREN WITH CYSTIC FIBROSIS (Conference Paper)

McWilliam, S. J., Antoine, D. J., Rosala-Hallas, A., Jones, A., MacLean, C., Prayle, A., . . . Pirmohamed, M. (2017). THE PROTEKT STUDY - A PHASE IIA, RANDOMISED, CONTROLLED, OPEN-LABEL TRIAL OF ROSUVASTATIN FOR THE PREVENTION OF AMINOGLYCOSIDE-INDUCED KIDNEY TOXICITY IN CHILDREN WITH CYSTIC FIBROSIS. In PEDIATRIC PULMONOLOGY Vol. 52 (pp. S353). Indiana Convention Center, Indianapolis, Indiana. doi:10.1002/ppul.23840

DOI: 10.1002/ppul.23840

The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors (Journal article)

Gibson, A., Faulkner, L., Lichtenfels, M., Ogese, M., Al-Attar, Z., Alfirevic, A., . . . Naisbitt, D. J. (2017). The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors. JOURNAL OF IMMUNOLOGY, 199(4), 1223-1237. doi:10.4049/jimmunol.1602029

DOI: 10.4049/jimmunol.1602029

17q21 gene variation increases the risk of exacerbations in asthmatic children treated with inhaled corticosteroids: A meta-analysis in the multi-ethnic pica consortium (Conference Paper)

Farzan, N., Vijverberg, S. J., Hernandez-Pacheco, N., Berce, V., Burchard, E. G., Canino, G., . . . Maitland-Van der Zee, A. H. (2017). 17q21 gene variation increases the risk of exacerbations in asthmatic children treated with inhaled corticosteroids: A meta-analysis in the multi-ethnic pica consortium. In ALLERGY Vol. 72 (pp. 269-270). Retrieved from http://gateway.webofknowledge.com/

A prospective cohort study examining the effectiveness of baclofen in the maintenance of abstinence in alcohol use disorder patients attending a joint liver and alcohol treatment clinic (Journal article)

Owens, L., Thompson, A., Rose, A., Gilmore, I., Pirmohamed, M., & Richardson, P. (2017). A prospective cohort study examining the effectiveness of baclofen in the maintenance of abstinence in alcohol use disorder patients attending a joint liver and alcohol treatment clinic. Alcohol, 62, 11-15. doi:10.1016/j.alcohol.2016.12.005

DOI: 10.1016/j.alcohol.2016.12.005

CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia (Journal article)

Siddiqui, M. K., Veluchamy, A., Maroteau, C., Tavendale, R., Carr, F., Pearson, E., . . . Consortium, P. R. E. D. I. C. T. I. O. N. -A. D. R. (2017). CKM Glu83Gly Is Associated With Blunted Creatine Kinase Variation, but Not With Myalgia. CIRCULATION-CARDIOVASCULAR GENETICS, 10(4). doi:10.1161/CIRCGENETICS.117.001737

DOI: 10.1161/CIRCGENETICS.117.001737

Genome-Wide Association Study of Asthma Exacerbations in European Children Treated with Inhaled Corticosteroids (Conference Paper)

Vijverberg, S. J. H., Hernandez-Pacheco, N., Farzan, N., Francis, B., Flores, C., Schieck, M., . . . Maitland-van der Zee, A. -H. (2017). Genome-Wide Association Study of Asthma Exacerbations in European Children Treated with Inhaled Corticosteroids. In PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol. 26 (pp. 25-26). Retrieved from http://gateway.webofknowledge.com/

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients (Journal article)

Yip, V. L. M., Meng, X., Maggs, J. L., Jenkins, R., Marlot, P., Marson, A., . . . Pirmohamed, M. (2017). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients. Chemical Research in Toxicology, 30(7), 1419-1435. doi:10.1021/acs.chemrestox.7b00063

DOI: 10.1021/acs.chemrestox.7b00063

Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium (vol 101, pg 341, 2017) (Journal article)

van der Wouden, C. H., Cambon-Thomsen, A., Cecchin, E., Cheung, K. C., Davila-Fajardo, C. L., Deneer, V. H., . . . Pharmacogenomics, U. (2017). Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium (vol 101, pg 341, 2017). CLINICAL PHARMACOLOGY & THERAPEUTICS, 102(1), 152. doi:10.1002/cpt.725

DOI: 10.1002/cpt.725

Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium (Journal article)

Hawcutt, D. B., & Pirmohamed, M. (2017). Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium. Pharmacogenomics, 18(10), 931-943. doi:10.2217/pgs-2017-0035

DOI: 10.2217/pgs-2017-0035

Stroke Pharmacogenetics (Chapter)

Walker, L. E., Stewart, A., & Pirmohamed, S. M. (2017). Stroke Pharmacogenetics. In P. Sharma, & J. F. Meschia (Eds.), Stroke Genetics (pp. 327-410). Springer. doi:10.1007/978-3-319-56210-0_17

DOI: 10.1007/978-3-319-56210-0_17

NILOTINIB-INDUCED METABOLIC DYSFUNCTION: INSIGHTS FROM A TRANSLATIONAL PILOT STUDY USING IN VITRO ADIPOCYTE MODELS AND PATIENT COHORTS (Poster)

Sadiq, S., Owen, E., Foster, T., Knight, K., Wang, L., Pirmohamed, M., . . . Pushpakom, S. (2017). NILOTINIB-INDUCED METABOLIC DYSFUNCTION: INSIGHTS FROM A TRANSLATIONAL PILOT STUDY USING IN VITRO ADIPOCYTE MODELS AND PATIENT COHORTS. Poster session presented at the meeting of Unknown Conference. Retrieved from http://gateway.webofknowledge.com/

Development of ELISAs for diagnosis of acute typhoid fever in Nigerian children (Journal article)

Felgner, J., Jain, A., Nakajima, R., Liang, L., Jasinskas, A., Gotuzzo, E., . . . Davies, D. H. (2017). Development of ELISAs for diagnosis of acute typhoid fever in Nigerian children. PLOS NEGLECTED TROPICAL DISEASES, 11(6). doi:10.1371/journal.pntd.0005679

DOI: 10.1371/journal.pntd.0005679

Mechanistic biomarkers stratify patients after paracetamol overdose with high sensitivity and specificity (Conference Paper)

Dear, J. W., Clarke, J. I., Francis, B., Philips, L., Wraight, J., Dargan, P. I., . . . Antoine, D. J. (2017). Mechanistic biomarkers stratify patients after paracetamol overdose with high sensitivity and specificity. In CLINICAL TOXICOLOGY Vol. 55 (pp. 468). Retrieved from http://gateway.webofknowledge.com/

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy (Journal article)

Ricci, E. (2017). Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy. Journal of Clinical Investigation, 127(6), 2118-2132. doi:10.1172/JCI92001

DOI: 10.1172/JCI92001

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Standard Reporting and Evaluation Guidelines: Results of a National Institutes of Health Working Group. (Journal article)

Maverakis, E., Wang, E. A., Shinkai, K., Mahasirimongkol, S., Margolis, D. J., Avigan, M., . . . Cheng, M. Y. (2017). Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Standard Reporting and Evaluation Guidelines Results of a National Institutes of Health Working Group. JAMA DERMATOLOGY, 153(6), 587-592. doi:10.1001/jamadermatol.2017.0160

DOI: 10.1001/jamadermatol.2017.0160

Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response (Journal article)

Zhang, J. E., Klein, K., Jorgensen, A. L., Francis, B., Alfirevic, A., Bourgeois, S., . . . Pirmohamed, M. (2017). Effect of Genetic Variability in the CYP4F2, CYP4F11, and CYP4F12 Genes on Liver mRNA Levels and Warfarin Response. FRONTIERS IN PHARMACOLOGY, 8. doi:10.3389/fphar.2017.00323

DOI: 10.3389/fphar.2017.00323

17q21 Gene Variance Increases The Risk Of Exacerbations In Asthmatic Children Treated With Inhaled Corticosteroids: A Meta-Analysis In The Pica Consortium (Conference Paper)

Farzan, N., Vijverberg, S., Hernandez-Pacheco, N., Berce, V., Burchard, E. G., Canino, G., . . . Maitland-van Der Zee, A. -H. (2017). 17q21 Gene Variance Increases The Risk Of Exacerbations In Asthmatic Children Treated With Inhaled Corticosteroids: A Meta-Analysis In The Pica Consortium. In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE Vol. 195. Washington DC. Retrieved from http://gateway.webofknowledge.com/

EXAMINATION OF EQUITY IN THE DELIVERY OF PERSONALISED MEDICINES (Conference Paper)

Martin, A. P., Haycox, A., Downing, J., Alfirevic, A., & Pirmohamed, M. (2016). EXAMINATION OF EQUITY IN THE DELIVERY OF PERSONALISED MEDICINES. In VALUE IN HEALTH Vol. 19 (pp. A266). doi:10.1016/j.jval.2016.03.771

Genetic regulation of gene expression in the epileptic human hippocampus (Journal article)

Mirza, N., Appleton, R., Burn, S., du Plessis, D., Duncan, R., Farah, J. O., . . . Pirmohamed, M. (2017). Genetic regulation of gene expression in the epileptic human hippocampus. HUMAN MOLECULAR GENETICS, 26(9), 1759-1769. doi:10.1093/hmg/ddx061

DOI: 10.1093/hmg/ddx061

Time to onset of bisphosphonate-related osteonecrosis of the jaws: a multicentre retrospective cohort study (Journal article)

Fung, P. P. L., Bedogni, G., Bedogni, A., Petrie, A., Porter, S., Campisi, G., . . . Fedele, S. (2017). Time to onset of bisphosphonate-related osteonecrosis of the jaws: a multicentre retrospective cohort study. ORAL DISEASES, 23(4), 477-483. doi:10.1111/odi.12632

DOI: 10.1111/odi.12632

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-wide Association Study. (Journal article)

Nicoletti, P., Aithal, G. P., Bjornsson, E. S., Andrade, R. J., Sawle, A., Arrese, M., . . . Daly, A. K. (2017). Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-wide Association Study.. Gastroenterology, 152(5), 1078-1089. doi:10.1053/j.gastro.2016.12.016

DOI: 10.1053/j.gastro.2016.12.016

Genome-Wide Association Study of Nevirapine Hypersensitivity in a sub-Saharan African HIV-infected Population (Journal article)

Carr, D. F., Bourgeois, S., Chaponda, M., Takeshita, L., Morris, A., Cornejo Castro, E. M., . . . Pirmohamed, M. (2017). Genome-Wide Association Study of Nevirapine Hypersensitivity in a sub-Saharan African HIV-infected Population. Journal of Antimicrobial Chemotherapy, 72(4), 1152-1162. doi:10.1093/jac/dkw545

DOI: 10.1093/jac/dkw545

Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury (Journal article)

Carr, D. F., Ayehunie, S., Davies, A., Duckworth, C. A., French, S., Hall, N., . . . Pirmohamed, M. (2017). Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury. PHARMACOLOGY & THERAPEUTICS, 172, 181-194. doi:10.1016/j.pharmthera.2017.01.002

DOI: 10.1016/j.pharmthera.2017.01.002

Epidemiology of alcohol dependence in UK primary care: Results from a large observational study using the Clinical Practice Research Datalink (Journal article)

Thompson, A., Wright, A. K., Ashcroft, D. M., van Staa, T. P., & Pirmohamed, M. (2017). Epidemiology of alcohol dependence in UK primary care: Results from a large observational study using the Clinical Practice Research Datalink. PLOS ONE, 12(3). doi:10.1371/journal.pone.0174818

DOI: 10.1371/journal.pone.0174818

Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study (Journal article)

Thompson, A., Ashcroft, D. M., Owens, L., van Staa, T. P., & Pirmohamed, M. (2017). Drug therapy for alcohol dependence in primary care in the UK: A Clinical Practice Research Datalink study. PLOS ONE, 12(3). doi:10.1371/journal.pone.0173272

DOI: 10.1371/journal.pone.0173272

Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. (Journal article)

Dickens, D., Chiduza, G. N., Wright, G. S. A., Pirmohamed, M., Antonyuk, S. V., & Hasnain, S. S. (n.d.). Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.. Scientific Reports, 7. doi:10.1038/srep43580

DOI: 10.1038/srep43580

Age-stratified outcome of a genotype-guided dosing algorithm for acenocoumarol and phenprocoumon (Journal article)

Zhang, Y., de Boer, A., Verhoef, T. I., van der Meer, F. J. M., Le Cessie, S., Manolopoulos, V. G., . . . Grp, E. U. -P. A. C. T. (2017). Age-stratified outcome of a genotype-guided dosing algorithm for acenocoumarol and phenprocoumon. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 15(3), 454-464. doi:10.1111/jth.13601

DOI: 10.1111/jth.13601

Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium. (Journal article)

van der Wouden, C. H., Cambon-Thomsen, A., Cecchin, E., Cheung, K. C., Davila-Fajardo, C. L., Deneer, V. H., . . . Consor, U. P. (2017). Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium. CLINICAL PHARMACOLOGY & THERAPEUTICS, 101(3), 341-358. doi:10.1002/cpt.602

DOI: 10.1002/cpt.602

Assessment of gene expression profiles of peripheral blood mononuclear cells from patients with a history of carbamazepine hypersensitivity (Conference Paper)

Yip, V., Zhang, E., Clarke, K., Francis, B., Rainbow, L., Falciani, F., . . . Pirmohamed, M. (2017). Assessment of gene expression profiles of peripheral blood mononuclear cells from patients with a history of carbamazepine hypersensitivity. In LANCET Vol. 389 (pp. 104). Retrieved from http://gateway.webofknowledge.com/

Identifying new antiepileptic drugs through genomics-based drug repurposing (Journal article)

Mirza, N., Sills, G. J., Pirmohamed, M., & Marson, A. G. (2017). Identifying new antiepileptic drugs through genomics-based drug repurposing. HUMAN MOLECULAR GENETICS, 26(3), 527-537. doi:10.1093/hmg/ddw410

DOI: 10.1093/hmg/ddw410

The HLA-A*31:01 allele: influence on carbamazepine treatment (Journal article)

Yip, V. L. M., & Pirmohamed, M. (2017). The HLA-A*31:01 allele: influence on carbamazepine treatment. Pharmacogenomics and Personalized Medicine, 10, 29-38. doi:10.2147/PGPM.S108598

DOI: 10.2147/PGPM.S108598

New Approaches to Investigate Drug-Induced Hypersensitivity (Journal article)

Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., . . . Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. CHEMICAL RESEARCH IN TOXICOLOGY, 30(1), 239-259. doi:10.1021/acs.chemrestox.6b00333

DOI: 10.1021/acs.chemrestox.6b00333

Open letter on access to the BIA 10-2474 clinical trial data (Journal article)

Brosen, K., Funck-Brentano, C., Kroemer, H. K., Pirmohamed, M., & Schwab, M. (2017). Open letter on access to the BIA 10-2474 clinical trial data. LANCET, 389(10065), 156. doi:10.1016/S0140-6736(16)32515-6

DOI: 10.1016/S0140-6736(16)32515-6

The impact of P450 oxidoreductase knock out on systemic exposure to rosuvastatin, atorvastatin and atorvastatin metabolites (Conference Paper)

Turner, R. M., Bayliss, M., Carr, D., Kitteringham, N., Henderson, C., & Pirmohamed, M. (2016, December 13). The impact of P450 oxidoreductase knock out on systemic exposure to rosuvastatin, atorvastatin and atorvastatin metabolites. In http://www.pa2online.org/abstract/abstract.jsp?abid=33238&kw=P450%20oxidoreductase&cat=-1&period=-1. London, UK.

Development of the Liverpool Adverse Drug Reaction Avoidability Assessment Tool (Journal article)

Bracken, L., Nunn, A., Kirkham, J. J., Peak, M., Arnott, J., Smyth, R. L., . . . Turner, M. (2017). Development of the Liverpool Adverse Drug Reaction Avoidability Assessment Tool. PLoS ONE, 12(1). doi:10.1371/journal.pone.0169393

DOI: 10.1371/journal.pone.0169393

Defining drug response for stratified medicine. (Journal article)

Lonergan, M., Senn, S. J., McNamee, C., Daly, A. K., Sutton, R., Hattersley, A., . . . Pirmohamed, M. (2017). Defining drug response for stratified medicine. DRUG DISCOVERY TODAY, 22(1), 173-179. doi:10.1016/j.drudis.2016.10.016

DOI: 10.1016/j.drudis.2016.10.016

Genomics of Adverse Drug Reactions (Journal article)

Alfirevic, A., & Pirmohamed, M. (2017). Genomics of Adverse Drug Reactions. TRENDS IN PHARMACOLOGICAL SCIENCES, 38(1), 100-109. doi:10.1016/j.tips.2016.11.003

DOI: 10.1016/j.tips.2016.11.003

Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevation acute coronary syndrome (Journal article)

Turner, R. M., Yin, P., Hanson, A., FitzGerald, R., Morris, A. P., Stables, R. H., . . . Pirmohamed, M. (2017). Investigating the prevalence, predictors, and prognosis of suboptimal statin use early after a non-ST elevation acute coronary syndrome. Journal of Clinical Lipidology, 11(1), 204-214. doi:10.1016/j.jacl.2016.12.007

DOI: 10.1016/j.jacl.2016.12.007

PHARMACOGENOMICS: RELEVANCE TO PERSONALIZED MEDICINE (Conference Paper)

Pirmohamed, M. (2017). PHARMACOGENOMICS: RELEVANCE TO PERSONALIZED MEDICINE. In DRUG METABOLISM AND PHARMACOKINETICS Vol. 32 (pp. S10). Retrieved from http://gateway.webofknowledge.com/

STATIN-INDUCED MYTOTOXICITY (Conference Paper)

Pirmohamed, M. (2017). STATIN-INDUCED MYTOTOXICITY. In DRUG METABOLISM AND PHARMACOKINETICS Vol. 32 (pp. S10). Retrieved from http://gateway.webofknowledge.com/

TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity (Journal article)

Thiesen, S., Yin, P., Jorgensen, A. L., Zhang, J. E., Manzo, V., McEvoy, L., . . . Pirmohamed, M. (2017). TPMT, COMT and ACYP2 genetic variants in paediatric cancer patients with cisplatin-induced ototoxicity. PHARMACOGENETICS AND GENOMICS, 27(6), 213-222. doi:10.1097/FPC.0000000000000281

DOI: 10.1097/FPC.0000000000000281

2016

A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity (Presentation material)

Yip, V. L. M., Meng, X., Maggs, J. L., Pertinez, H., Carr, D. F., Marson, A. G., . . . Pirmohamed, M. (2016). A combination of clinical and genetic covariates significantly influence the metabolism of carbamazepine: potential implications for carbamazepine hypersensitivity. London, UK.

A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease (Journal article)

Walker, L., Griffiths, M. J., McGill, F., Lewthwaite, P., Sills, G. J., Jorgensen, A., . . . Pirmohamed, M. (2016). A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease. Biomarkers, 22(7), 635-642. doi:10.1080/1354750X.2016.1265003

DOI: 10.1080/1354750X.2016.1265003

Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity (Journal article)

Faulkner, L., Gibson, A., Sullivan, A., Tailor, A., Usui, T., Alfirevic, A., . . . Park, B. K. (2016). Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity. TOXICOLOGICAL SCIENCES, 154(2), 416-429. doi:10.1093/toxsci/kfw177

DOI: 10.1093/toxsci/kfw177

Discordant CSF/plasma HIV-1 RNA in patients with unexplained low-level viraemia (Journal article)

Nightingale, S., Geretti, A. M., Beloukas, A., Fisher, M., Winston, A., Else, L., . . . Khoo, S. (2016). Discordant CSF/plasma HIV-1 RNA in patients with unexplained low-level viraemia. Journal of NeuroVirology, 22, 852-860. doi:10.1007/s13365-016-0448-1

DOI: 10.1007/s13365-016-0448-1

Genotype-guided warfarin dosing (Presentation material)

Yip, V. L. M., & Pirmohamed, M. (2016). Genotype-guided warfarin dosing. Manchester, UK.

Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis (Journal article)

Fjeld, K., Beer, S., Johnstone, M., Zimmer, C., Moessner, J., Ruffert, C., . . . Rosendahl, J. (2016). Length of Variable Numbers of Tandem Repeats in the Carboxyl Ester Lipase (CEL) Gene May Confer Susceptibility to Alcoholic Liver Cirrhosis but Not Alcoholic Chronic Pancreatitis. PLOS ONE, 11(11). doi:10.1371/journal.pone.0165567

DOI: 10.1371/journal.pone.0165567

Nephrotoxicity in Children Receiving Chemotherapy - 'Omics and Biomarkers (Conference Paper)

Barton, C., Pizer, B., Hawcutt, D., Pirmohamed, M., Hemsworth, S., & Hincks, E. (2016). Nephrotoxicity in Children Receiving Chemotherapy - 'Omics and Biomarkers. In PEDIATRIC BLOOD & CANCER Vol. 63 (pp. S121-S122). Retrieved from http://gateway.webofknowledge.com/

SNP-Treatment Interactions of Cardiovascular Medications and Risk of Acute Coronary Syndrome Recurrence (Conference Paper)

Yin, P., Jorgensen, A., Morris, A., Turner, R., Fitzgerald, R., Stables, R., . . . Pirmohamed, M. (2016). SNP-Treatment Interactions of Cardiovascular Medications and Risk of Acute Coronary Syndrome Recurrence. In GENETIC EPIDEMIOLOGY Vol. 40 (pp. 672). Retrieved from http://gateway.webofknowledge.com/

Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients (Journal article)

Qin, S., Zhou, Y., Gray, L., Kusebauch, U., McEvoy, L., Antoine, D. J., . . . Hood, L. (2016). Identification of Organ-Enriched Protein Biomarkers of Acute Liver Injury by Targeted Quantitative Proteomics of Blood in Acetaminophen- and Carbon-Tetrachloride-Treated Mouse Models and Acetaminophen Overdose Patients. Journal of proteome research, 15(10), 3724-3740. doi:10.1021/acs.jproteome.6b00547

DOI: 10.1021/acs.jproteome.6b00547

A candidate gene study for oxaliplatin induced chronic peripheral neuropathy (OICPN) based on a prior genome wide association study (GWAS) (Conference Paper)

Cliff, J. R., Carr, D. F., Lord, R. H., Jorgensen, A. L., & Pirmohamed, M. (2016). A candidate gene study for oxaliplatin induced chronic peripheral neuropathy (OICPN) based on a prior genome wide association study (GWAS). In ANNALS OF ONCOLOGY Vol. 27. doi:10.1093/annonc/mdw392.54

DOI: 10.1093/annonc/mdw392.54

Cost-effectiveness of pharmacogenetic-guided dosing of warfarin in the United Kingdom and Sweden (Journal article)

Verhoef, T. I., Redekop, W. K., Langenskiold, S., Kamali, F., Wadelius, M., Burnside, G., . . . Pirmohamed, M. (2016). Cost-effectiveness of pharmacogenetic-guided dosing of warfarin in the United Kingdom and Sweden. PHARMACOGENOMICS JOURNAL, 16(5), 478-484. doi:10.1038/tpj.2016.41

DOI: 10.1038/tpj.2016.41

A Randomized Controlled Trial of Extended Brief Intervention for Alcohol-Dependent Patients in an Acute Hospital Setting (Journal article)

Owens, L., Kolamunnage-Dona, R., Owens, A., Perkins, E., Butcher, G., Wilson, K., . . . Pirmohamed, M. (2016). A Randomized Controlled Trial of Extended Brief Intervention for Alcohol-Dependent Patients in an Acute Hospital Setting. Alcohol and Alcoholism, 51(05), 584-592. doi:10.1093/alcalc/agw023

DOI: 10.1093/alcalc/agw023

An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters (Journal article)

Mirza, N., Vasieva, O., Appleton, R., Burn, S., Carr, D., Crooks, D., . . . Pirmohamed, M. (2016). An integrative in silico system for predicting dysregulated genes in the human epileptic focus: Application to SLC transporters. EPILEPSIA, 57(9), 1467-1474. doi:10.1111/epi.13473

DOI: 10.1111/epi.13473

Defining uncontrolled childhood asthma in the global PiCA consortium (Conference Paper)

Farzan, N., Vijverberg, S. J., Andiappan, A. K., Blanca-Lopez, N., Bonnelykke, K., Campo, P., . . . Maitland-van der Zee, A. H. (2016). Defining uncontrolled childhood asthma in the global PiCA consortium. In EUROPEAN RESPIRATORY JOURNAL Vol. 48. doi:10.1183/13993003.congress-2016.PA4388

DOI: 10.1183/13993003.congress-2016.PA4388

PAEDIATRIC ADVERSE DRUG REACTIONS (ADRS): A COMPARISON OF A NEWLY DEVELOPED AVOIDABILITY TOOL TO EXISTING HALLAS ASSESSMENTS. (Poster)

Bracken, L., Kirkham, J., Nunn, A., Pirmohamed, M., Peak, M., & Turner, M. (2016). PAEDIATRIC ADVERSE DRUG REACTIONS (ADRS): A COMPARISON OF A NEWLY DEVELOPED AVOIDABILITY TOOL TO EXISTING HALLAS ASSESSMENTS.. Poster session presented at the meeting of Unknown Conference.

DOI: 10.1136/archdischild-2016-311535.72

Personalized Medicine in Cardiovascular Disease (Chapter)

Turner, R. M., Bula, M., & Pirmohamed, M. (2016). Personalized Medicine in Cardiovascular Disease. In W. B. Coleman, & G. J. Tsongalis (Eds.), Diagnostic Molecular Pathology A Guide to Applied Molecular Testing (pp. 457-471). Academic Press.

A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions (Journal article)

Plumpton, C. O., Roberts, D., Pirmohamed, M., & Hughes, D. A. (2016). A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions. PHARMACOECONOMICS, 34(8), 771-793. doi:10.1007/s40273-016-0397-9

DOI: 10.1007/s40273-016-0397-9

Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G -> T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis (Journal article)

Nightingale, S., Chau, T. T. H., Fisher, M., Nelson, M., Winston, A., Else, L., . . . Grp, P. -V. S. (2016). Efavirenz and Metabolites in Cerebrospinal Fluid: Relationship with CYP2B6 c.516G -> T Genotype and Perturbed Blood-Brain Barrier Due to Tuberculous Meningitis. Antimicrobial Agents and Chemotherapy, 60(8), 4511-4518. doi:10.1128/AAC.00280-16

DOI: 10.1128/AAC.00280-16

CSF/plasma HIV-1 RNA discordance even at low levels is associated with up-regulation of host inflammatory mediators in CSF (Journal article)

Nightingale, S., Michael, B. D., Fisher, M., Winston, A., Nelson, M., Taylor, S., . . . Solomon, T. (2016). CSF/plasma HIV-1 RNA discordance even at low levels is associated with up-regulation of host inflammatory mediators in CSF. Cytokine, 83, 139-146. doi:10.1016/j.cyto.2016.04.004

DOI: 10.1016/j.cyto.2016.04.004

Childhood asthma exacerbations and the Arg16 beta(2)-receptor polymorphism: A meta-analysis stratified by treatment (Journal article)

Turner, S., Francis, B., Vijverberg, S., Pino-Yanes, M., Maitland-van der Zee, A. H., Basu, K., . . . Asthma, P. C. (2016). Childhood asthma exacerbations and the Arg16 beta(2)-receptor polymorphism: A meta-analysis stratified by treatment. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 138(1), 107-113.E5. doi:10.1016/j.jaci.2015.10.045

DOI: 10.1016/j.jaci.2015.10.045

Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21,-200c, and-423 (Journal article)

Pavkovic, M., Robinson-Cohen, C., Chua, A. S., Nicoara, O., Cardenas-Gonzalez, M., Bijol, V., . . . Vaidya, V. S. (2016). Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21,-200c, and-423. TOXICOLOGICAL SCIENCES, 152(1), 205-213. doi:10.1093/toxsci/kfw077

DOI: 10.1093/toxsci/kfw077

Pharmacogenetics for the prescriber (Journal article)

Pirmohamed, M. (2016). Pharmacogenetics for the prescriber. Medicine, 44(7), 412-415. doi:10.1016/j.mpmed.2016.04.010

DOI: 10.1016/j.mpmed.2016.04.010

The role of Clostridium difficile in the paediatric and neonatal gut - a narrative review (Journal article)

Lees, E. A., Miyajima, F., Pirmohamed, M., & Carrol, E. D. (2016). The role of Clostridium difficile in the paediatric and neonatal gut - a narrative review. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 35(7), 1047-1057. doi:10.1007/s10096-016-2639-3

DOI: 10.1007/s10096-016-2639-3

Pharmacogenetics and Pharmacogenomics (Chapter)

Alfirevic, A., & Pirmohamed, M. (2016). Pharmacogenetics and Pharmacogenomics. In Medical and Health Genomics (pp. 121-137). Elsevier. doi:10.1016/b978-0-12-420196-5.00010-1

DOI: 10.1016/b978-0-12-420196-5.00010-1

A PROSPECTIVE OPEN COHORT STUDY EXAMINING THE EFFECTIVENESS OF BACLOFEN IN AUD PATIENTS ATTENDING A JOINT LIVER AND ALCOHOL TREATMENT CLINIC (Conference Paper)

Owens, L., Thompson, A., Rose, A., Pirmohamed, M., Gilmore, I., & Richardson, P. (2016). A PROSPECTIVE OPEN COHORT STUDY EXAMINING THE EFFECTIVENESS OF BACLOFEN IN AUD PATIENTS ATTENDING A JOINT LIVER AND ALCOHOL TREATMENT CLINIC. In ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH Vol. 40 (pp. 275A). Retrieved from http://gateway.webofknowledge.com/

Adrenal responses to a low-dose short synacthen test in children with asthma (vol 82, pg 648, 2015) (Journal article)

Hawcutt, D. B., Jorgensen, A. L., Wallin, N., Thompson, B., Peak, M., Lacy, D., . . . Smyth, R. L. (2016). Adrenal responses to a low-dose short synacthen test in children with asthma (vol 82, pg 648, 2015). CLINICAL ENDOCRINOLOGY, 84(5), 793. doi:10.1111/cen.13069

DOI: 10.1111/cen.13069

HLA-B*38:02:01 Predicts Carbimazole/Methimazole-Induced Agranulocytosis (Journal article)

Cheung, C. -L., Sing, C. -W., Tang, C. S. M., Cheng, V. K. F., Pirmohamed, M., Choi, C. -H., . . . Kung, A. W. C. (2016). HLA-B*38:02:01 Predicts Carbimazole/Methimazole-Induced Agranulocytosis. CLINICAL PHARMACOLOGY & THERAPEUTICS, 99(5), 555-561. doi:10.1002/cpt.309

DOI: 10.1002/cpt.309

HLA-B*38:02:01 predicts carbimazole/methimazole-induced agranulocytosis (Journal article)

Cheung, C. L., Sing, C. W., Tang, C. S. M., Cheng, V. K. F., Pirmohamed, M., Choi, C. H., . . . Kung, A. W. C. (2016). HLA-B*38:02:01 predicts carbimazole/methimazole-induced agranulocytosis. Clinical Pharmacology and Therapeutics, 99(5), 555-561. doi:10.1002/cpt.309

DOI: 10.1002/cpt.309

Pharmacogenetics (Book)

Hall, I. P., & Pirmohamed, M. (2016). Pharmacogenetics.

Pharmacogenetics and metabolic disease (Chapter)

Constable, S., & Pirmohamed, M. (2016). Pharmacogenetics and metabolic disease. In Pharmacogenetics (pp. 243-272).

Pharmacogenetics of adverse drug reactions (Chapter)

Alfirevic, A., Park, B. K., & Pirmohamed, M. (2016). Pharmacogenetics of adverse drug reactions. In Pharmacogenetics (pp. 65-89).

Preface (Book)

Hall, I. P., & Pirmohamed, M. (2016). Preface.

Pivotal role of NFATc4 in antiretroviral-induced adipocyte toxicity (Poster)

Majid, R., Pushpakom, S., & Pirmohamed, M. (2016). Pivotal role of NFATc4 in antiretroviral-induced adipocyte toxicity. Poster session presented at the meeting of Unknown Conference. Retrieved from http://gateway.webofknowledge.com/

Genome-Based Infection Tracking Reveals Dynamics of Clostridium difficile Transmission and Disease Recurrence (Journal article)

Kumar, N., Miyajima, F., He, M., Roberts, P., Swale, A., Ellison, L., . . . Lawley, T. D. (2016). Genome-Based Infection Tracking Reveals Dynamics of Clostridium difficile Transmission and Disease Recurrence. Clinical Infectious Diseases, 62(6), 746-752. doi:10.1093/cid/civ1031

DOI: 10.1093/cid/civ1031

Achieving the World Health Organization's vision for clinical pharmacology (Journal article)

Martin, J. H., Henry, D., Gray, J., Day, R., Bochner, F., Ferro, A., . . . Schwab, M. (2016). Achieving the World Health Organization's vision for clinical pharmacology. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 81(2), 223-227. doi:10.1111/bcp.12803

DOI: 10.1111/bcp.12803

A multi-factorial analysis of response to warfarin in a UK prospective cohort (Journal article)

Bourgeois, S., Jorgensen, A., Zhang, E. J., Hanson, A., Gillman, M. S., Bumpstead, S., . . . Pirmohamed, M. (2016). A multi-factorial analysis of response to warfarin in a UK prospective cohort. Genome Medicine: medicine in the post-genomic era, 8. doi:10.1186/s13073-015-0255-y

DOI: 10.1186/s13073-015-0255-y

Precision Dosing in Children (Journal article)

Hawcutt, D. B., Cooney, L., Oni, L., & Pirmohamed, M. (2016). Precision Dosing in Children. Expert Review of Precision Medicine and Drug Development, 1(1), 69-78. doi:10.1080/23808993.2016.1138845

DOI: 10.1080/23808993.2016.1138845

Advances in the Pharmacogenomics of Adverse Drug Reactions (Journal article)

Collins, S. L., Carr, D. F., & Pirmohamed, M. (2016). Advances in the Pharmacogenomics of Adverse Drug Reactions. DRUG SAFETY, 39(1), 15-27. doi:10.1007/s40264-015-0367-8

DOI: 10.1007/s40264-015-0367-8

Chapter 5. Drug Transporters at the Blood–Brain Barrier (Chapter)

Dickens, D., Radisch, S., & Pirmohamed, M. (n.d.). Chapter 5. Drug Transporters at the Blood–Brain Barrier. In Drug Transporters : Role and Importance in ADME and Drug Development (pp. 151-183). Royal Society of Chemistry. doi:10.1039/9781782623793-00151

DOI: 10.1039/9781782623793-00151

Progress in pharmacogenetics: consortiums and new strategies. (Journal article)

Maroñas, O., Latorre, A., Dopazo, J., Pirmohamed, M., Rodríguez-Antona, C., Siest, G., . . . LLerena, A. (2016). Progress in pharmacogenetics: consortiums and new strategies.. Drug metabolism and personalized therapy, 31(1), 17-23. doi:10.1515/dmpt-2015-0039

DOI: 10.1515/dmpt-2015-0039

2015

Redefining antigen binding specificity through small molecule-HLA interactions: Drug hypersensitivity and beyond! (Conference Paper)

Illing, P. T., Vivian, J. P., Dudek, N. L., Mifsud, N. L., Croft, N. P., Miles, J. J., . . . Purcell, A. W. (2015). Redefining antigen binding specificity through small molecule-HLA interactions: Drug hypersensitivity and beyond!. In MOLECULAR IMMUNOLOGY Vol. 68 (pp. 135). Retrieved from http://gateway.webofknowledge.com/

HEALTH-ECONOMIC EVALUATION OF CLOSTRIDIUM DIFFICILE INFECTION (CDI) AND EPIDEMIOLOGY IN ENGLAND AND MERSEYSIDE (Journal article)

Nakamura, C. A., Roberts, P., Beadsworth, M., O'Brien, S., Pirmohamed, M., Hughes, D., & Miyajima, F. (2015). HEALTH-ECONOMIC EVALUATION OF CLOSTRIDIUM DIFFICILE INFECTION (CDI) AND EPIDEMIOLOGY IN ENGLAND AND MERSEYSIDE. VALUE IN HEALTH, 18(7), A582. doi:10.1016/j.jval.2015.09.1947

DOI: 10.1016/j.jval.2015.09.1947

A pilot randomised controlled trial to assess the utility of an e-learning package that trains users in adverse drug reaction causality. (Journal article)

Conroy, E., Kirkham, J., Bellis, J., Peak, M., Smyth, R., Williamson, P., & Pirmohamed, M. (2015). A pilot randomised controlled trial to assess the utility of an e-learning package that trains users in adverse drug reaction causality.. The International Journal of Pharmacy Practice, 23(6), 447-455. doi:10.1111/ijpp.12197

DOI: 10.1111/ijpp.12197

Monocyte unresponsiveness and impaired IL1ß, TNFa and IL7 production are associated with a poor outcome in Malawian adults with pulmonary tuberculosis (Journal article)

Waitt, C. J., Banda, P., Glennie, S., Kampmann, B., Squire, S. B., Pirmohamed, M., & Heyderman, R. S. (2015). Monocyte unresponsiveness and impaired IL1ß, TNFa and IL7 production are associated with a poor outcome in Malawian adults with pulmonary tuberculosis. BMC Infectious Diseases, 15. doi:10.1186/s12879-015-1274-4

DOI: 10.1186/s12879-015-1274-4

ACUTE KIDNEY INJURY IN PAEDIATRIC ONCOLOGY PATIENTS RECEIVING CISPLATIN (Journal article)

Barton, C., Hawcutt, D., Pirmohamed, M., & Pizer, B. (2015). ACUTE KIDNEY INJURY IN PAEDIATRIC ONCOLOGY PATIENTS RECEIVING CISPLATIN. PEDIATRIC BLOOD & CANCER, 62, S302-S303. Retrieved from http://gateway.webofknowledge.com/

Development of interferon beta-neutralising antibodies in multiple sclerosis-a systematic review and meta-analysis (Journal article)

Govindappa, K., Sathish, J., Park, K., Kirkham, J., & Pirmohamed, M. (2015). Development of interferon beta-neutralising antibodies in multiple sclerosis-a systematic review and meta-analysis. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 71(11), 1287-1298. doi:10.1007/s00228-015-1921-0

DOI: 10.1007/s00228-015-1921-0

MARKERS OF TUBULAR RENAL INJURY IN CHILDREN WITH CANCER RECEIVING CISPLATIN AND/OR IFOSFAMIDE (Journal article)

Barton, C., Hawcutt, D., Pirmohamed, M., & Pizer, B. (2015). MARKERS OF TUBULAR RENAL INJURY IN CHILDREN WITH CANCER RECEIVING CISPLATIN AND/OR IFOSFAMIDE. PEDIATRIC BLOOD & CANCER, 62, S302. Retrieved from http://gateway.webofknowledge.com/

Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: patients' and physicians' preferences for testing and service delivery (Journal article)

Powell, G., Holmes, E. A. F., Plumpton, C. O., Ring, A., Baker, G. A., Jacoby, A., . . . Hughes, D. A. (2015). Pharmacogenetic testing prior to carbamazepine treatment of epilepsy: patients' and physicians' preferences for testing and service delivery. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 80(5), 1149-1159. doi:10.1111/bcp.12715

DOI: 10.1111/bcp.12715

Pharmacogenetics of Acute Coronary Syndrome (Conference Paper)

Yin, P., Jorgensen, A., Morris, A. P., Turner, R., Fitzgerald, R., Stables, R., . . . Pirmohamed, M. (2015). Pharmacogenetics of Acute Coronary Syndrome. In GENETIC EPIDEMIOLOGY Vol. 39 (pp. 596). Retrieved from http://gateway.webofknowledge.com/

In Vitro Priming of Naive T-cells with p-Phenylenediamine and Bandrowski's Base (Journal article)

Gibson, A., Kim, S. -H., Faulkner, L., Evely, J., Pirmohamed, M., Park, K. B., & Naisbitt, D. J. (2015). In Vitro Priming of Naive T-cells with p-Phenylenediamine and Bandrowski's Base. CHEMICAL RESEARCH IN TOXICOLOGY, 28(10), 2069-2077. doi:10.1021/acs.chemrestox.5b00294

DOI: 10.1021/acs.chemrestox.5b00294

Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of telmisartan as a strategy for the reduction of insulin resistance in HIVpositive individuals on combination antiretroviral therapy (Journal article)

Pushpakom, S., Taylor, C., Kolamunnage-Dona, R., Spowart, C., Vora, J., Garcia Finana, M., . . . Pirmohamed, M. (2015). Telmisartan and Insulin Resistance in HIV (TAILoR): protocol for a dose-ranging phase II randomised open-labelled trial of telmisartan as a strategy for the reduction of insulin resistance in HIVpositive individuals on combination antiretroviral therapy. BMJ Open, 5(10). doi:10.1136/bmjopen-2015-009566

DOI: 10.1136/bmjopen-2015-009566

Genotype-guided versus standard vitamin K antagonist dosing algorithms in patients initiating anticoagulation (Journal article)

Belley-Cote, E. P., Hanif, H., D'Aragon, F., Eikelboom, J. W., Anderson, J. L., Borgman, M., . . . Whitlock, R. P. (n.d.). Genotype-guided versus standard vitamin K antagonist dosing algorithms in patients initiating anticoagulation. THROMBOSIS AND HAEMOSTASIS, 114(4), 768-777. doi:10.1160/TH15-01-0071

DOI: 10.1160/TH15-01-0071

HLA-A*33:01 is strongly associated with drug-induced liver injury (DILI) due to terbinafine and several other unrelated compounds (Conference Paper)

Aithal, G. P., Nicoletti, P., Bjornsson, E., Lucena, M. I., Andrade, R. J., Grove, J., . . . Daly, A. K. (2015). HLA-A*33:01 is strongly associated with drug-induced liver injury (DILI) due to terbinafine and several other unrelated compounds. In HEPATOLOGY Vol. 62 (pp. 325A-326A). Retrieved from http://gateway.webofknowledge.com/

Prescribing in liver disease (Journal article)

Pirmohamed, M. (2015). Prescribing in liver disease. Medicine, 43(10), 577-580. doi:10.1016/j.mpmed.2015.07.015

DOI: 10.1016/j.mpmed.2015.07.015

Social media and pharmacovigilance: A review of the opportunities and challenges (Journal article)

Sloane, R., Osanlou, O., Lewis, D., Bollegala, D., Maskell, S., & Pirmohamed, M. (2015). Social media and pharmacovigilance: A review of the opportunities and challenges. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 80(4), 910-920. doi:10.1111/bcp.12717

DOI: 10.1111/bcp.12717

A comprehensive omics assessment of etanercept therapy for psoriasis (Conference Paper)

Foulkes, A., Rattray, N., Pirmohamed, M., Goodacre, R., Reynolds, N. J., Donaldson, M. J., . . . Warren, R. (2015). A comprehensive omics assessment of etanercept therapy for psoriasis. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 135 (pp. S32). Retrieved from http://gateway.webofknowledge.com/

Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate–induced liver injury (Journal article)

Kim, S. -H., Saide, K., Farrell, J., Faulkner, L., Tailor, A., Ogese, M., . . . Naisbitt, D. J. (2015). Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate–induced liver injury. Hepatology, 62(3), 887-899. doi:10.1002/hep.27912

DOI: 10.1002/hep.27912

Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses (Conference Paper)

Gibson, A., Faulkner, L., Ogese, M., Lichtenfels, M., Esser, P., Martin, S., . . . Naisbitt, D. (2015). Identifying and characterising the complexities of sulfamethoxazole-specific T-cell responses. In ALLERGY Vol. 70 (pp. 26). Retrieved from http://gateway.webofknowledge.com/

Copy number variation in exportin-4 (XPO4) gene and its association with histological severity of non-alcoholic fatty liver disease (Journal article)

Zain, S. M., Mohamed, Z., Pirmohamed, M., Tan, H. L., Alshawsh, M. A., Mahadeva, S., . . . Mohamed, R. (2015). Copy number variation in exportin-4 (XPO4) gene and its association with histological severity of non-alcoholic fatty liver disease. SCIENTIFIC REPORTS, 5. doi:10.1038/srep13306

DOI: 10.1038/srep13306

Pharmacotherapy for alcohol dependence: A stratified approach (Journal article)

Thompson, A., Owens, L., Pushpakom, S. P., Faizal, M., & Pirmohamed, M. (2015). Pharmacotherapy for alcohol dependence: A stratified approach. PHARMACOLOGY & THERAPEUTICS, 153, 10-24. doi:10.1016/j.pharmthera.2015.05.010

DOI: 10.1016/j.pharmthera.2015.05.010

HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis (Journal article)

Ogese, M. O., Saide, K., Faulkner, L., Whitaker, P., Peckham, D., Alfirevic, A., . . . Naisbitt, D. J. (2015). HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis. CLINICAL AND EXPERIMENTAL ALLERGY, 45(8), 1305-1316. doi:10.1111/cea.12546

DOI: 10.1111/cea.12546

Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality (Journal article)

Mirza, N., Appleton, R., Burn, S., Carr, D. F., Crooks, D., du Plessis, D., . . . Pirmohamed, M. (2015). Identifying the biological pathways underlying human focal epilepsy: from complexity to coherence to centrality. Human Molecular Genetics, 24(15), 4306-4316. doi:10.1093/hmg/ddv163

DOI: 10.1093/hmg/ddv163

New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity (Journal article)

Pirmohamed, M., Ostrov, D. A., & Park, B. K. (2015). New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 236-244. doi:10.1016/j.jaci.2015.06.022

DOI: 10.1016/j.jaci.2015.06.022

Promiscuous T-cell responses to drugs and drug-haptens (Journal article)

Yaseen, F. S., Saide, K., Kim, S. -H., Monshi, M., Tailor, A., Wood, S., . . . Naisbitt, D. J. (2015). Promiscuous T-cell responses to drugs and drug-haptens. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136(2), 474-+. doi:10.1016/j.jaci.2015.02.036

DOI: 10.1016/j.jaci.2015.02.036

Variation in warfarin prescribing and dosing in the UK: a national survey of anticoagulation clinics (Journal article)

Stewart, A., Ganguli, A., FitzGerald, R., & Pirmohamed, M. (2015). Variation in warfarin prescribing and dosing in the UK: a national survey of anticoagulation clinics. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 40(4), 466-471. doi:10.1111/jcpt.12291

DOI: 10.1111/jcpt.12291

A comprehensive omics assessment of etanercept therapy for psoriasis (Conference Paper)

Foulkes, A., Rattray, N. J. W., Correa, E., Trivedi, D. K., Carr, D. F., Maratou, K., . . . Warren, R. (2015). A comprehensive omics assessment of etanercept therapy for psoriasis. In BRITISH JOURNAL OF DERMATOLOGY Vol. 173 (pp. 12). Retrieved from http://gateway.webofknowledge.com/

Genome-wide association study of warfarin maintenance dose in a Brazilian sample (Journal article)

Parra, E. J., Botton, M. R., Perini, J. A., Krithika, S., Bourgeois, S., Johnson, T. A., . . . Suarez-Kurtz, G. (2015). Genome-wide association study of warfarin maintenance dose in a Brazilian sample. PHARMACOGENOMICS, 16(11), 1253-1263. doi:10.2217/pgs.15.73

DOI: 10.2217/pgs.15.73

Parsing interindividual drug variability: an emerging role for systems pharmacology (Journal article)

Turner, R. M., Park, B. K., & Pirmohamed, M. (2015). Parsing interindividual drug variability: an emerging role for systems pharmacology. WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE, 7(4), 221-241. doi:10.1002/wsbm.1302

DOI: 10.1002/wsbm.1302

Quality of life in patients with venous thromboembolism and atrial fibrillation treated with coumarin anticoagulants (Journal article)

Marvig, C. L., Verhoef, T. I., de Boer, A., Kamali, F., Redekop, K., Pirmohamed, M., . . . Consortium, E. U. -P. A. C. T. (2015). Quality of life in patients with venous thromboembolism and atrial fibrillation treated with coumarin anticoagulants. THROMBOSIS RESEARCH, 136(1), 69-75. doi:10.1016/j.thromres.2015.04.026

DOI: 10.1016/j.thromres.2015.04.026

Pharmacogenetic Markers of Drug Efficacy and Toxicity. (Journal article)

Yip, V., Hawcutt, D., & Pirmohamed, M. (2015). Pharmacogenetic Markers of Drug Efficacy and Toxicity.. Clinical pharmacology and therapeutics, 98(1), 61-70. doi:10.1002/cpt.135

DOI: 10.1002/cpt.135

Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review (Journal article)

Yip, V. L. M., Alfirevic, A., & Pirmohamed, M. (2015). Genetics of Immune-Mediated Adverse Drug Reactions: a Comprehensive and Clinical Review. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 48(2-3), 165-175. doi:10.1007/s12016-014-8418-y

DOI: 10.1007/s12016-014-8418-y

Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry (Journal article)

Alfirevic, A., Durocher, J., Elati, A., Leon, W., Dickens, D., Raedisch, S., . . . Winikoff, B. (2015). Misoprostol-induced fever and genetic polymorphisms in drug transporters SLCO1B1 and ABCC4 in women of Latin American and European ancestry. PHARMACOGENOMICS, 16(9), 919-928. doi:10.2217/pgs.15.53

DOI: 10.2217/pgs.15.53

ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults (Journal article)

Vijverberg, S. J. H., Koster, E. S., Tavendale, R., Leusink, M., Koenderman, L., Raaijmakers, J. A. M., . . . Maitland-van der Zee, A. H. (2015). ST13 polymorphisms and their effect on exacerbations in steroid-treated asthmatic children and young adults. Clinical and Experimental Allergy, 45(6), 1051-1059. doi:10.1111/cea.12492

DOI: 10.1111/cea.12492

Adrenal responses to a low-dose short synacthen test in children with asthma (Journal article)

Hawcutt, D. B., Jorgensen, A. L., Wallin, N., Thompson, B., Peak, M., Lacy, D., . . . Smyth, R. L. (2015). Adrenal responses to a low-dose short synacthen test in children with asthma. CLINICAL ENDOCRINOLOGY, 82(5), 648-656. doi:10.1111/cen.12655

DOI: 10.1111/cen.12655

BACLOFEN: MAINTENANCE OF ABSTINENCE IN ALCOHOL DEPENDENT PATIENTS ATTENDING LIVER CLINIC (Conference Paper)

Owens, L., Rose, A., Thompson, A., Pirmohamed, M., Gilmore, I., & Richardson, P. (2015). BACLOFEN: MAINTENANCE OF ABSTINENCE IN ALCOHOL DEPENDENT PATIENTS ATTENDING LIVER CLINIC. In JOURNAL OF HEPATOLOGY Vol. 62 (pp. S767). doi:10.1016/S0168-8278(15)31309-X

DOI: 10.1016/S0168-8278(15)31309-X

CSF:plasma HIV-1 RNA discordance > 0.5 log(10) is associated with raised inflammatory mediator profiles in CSF (Journal article)

Nightingale, S., Michael, B., King, S., Beloukas, A., Pirmohamed, M., Geretti, A. M., . . . Post, F. (2015). CSF:plasma HIV-1 RNA discordance > 0.5 log(10) is associated with raised inflammatory mediator profiles in CSF. HIV MEDICINE, 16, 7. Retrieved from http://gateway.webofknowledge.com/

Cost-effectiveness of screening for HLA -A *31:01 prior to initiation of carbamazepine in epilepsy (Journal article)

Plumpton, C. O., Yip, V. L. M., Alfirevic, A., Marson, A. G., Pirmohamed, M., & Hughes, D. A. (2015). Cost-effectiveness of screening for HLA -A *31:01 prior to initiation of carbamazepine in epilepsy. EPILEPSIA, 56(04), 556-563. doi:10.1111/epi.12937

DOI: 10.1111/epi.12937

HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis. (Journal article)

Cornejo Castro, E. M., Carr, D., Jorgensen, A., Alfirevic, A., & Pirmohamed, M. (2015). HLA-allelotype associations with nevirapine-induced hypersensitivity reactions and hepatotoxicity: a systematic review of the literature and meta-analysis.. Pharmacogenetics and genomics, 25(04), 186-198. doi:10.1097/FPC.0000000000000124

DOI: 10.1097/FPC.0000000000000124

ADRIC: Adverse Drug Reactions In Children – a programme of research using mixed methods (Journal article)

Smyth, R. L., Peak, M., Turner, M. A., Nunn, A. J., Williamson, P. R., Young, B., . . . Pirmohamed, M. (2015). ADRIC: Adverse Drug Reactions In Children – a programme of research using mixed methods.

Management of allergy to penicillins and other beta-lactams (Journal article)

Mirakian, R., Leech, S. C., Krishna, M. T., Richter, A. G., Huber, P. A. J., Farooque, S., . . . Nasser, S. M. (2015). Management of allergy to penicillins and other beta-lactams. CLINICAL AND EXPERIMENTAL ALLERGY, 45(2), 300-327. doi:10.1111/cea.12468

DOI: 10.1111/cea.12468

Personalized medicine approaches in epilepsy (Journal article)

Walker, L. E., Mirza, N., Yip, V. L. M., Marson, A. G., & Pirmohamed, M. (2015). Personalized medicine approaches in epilepsy. JOURNAL OF INTERNAL MEDICINE, 277(2), 218-234. doi:10.1111/joim.12322

DOI: 10.1111/joim.12322

Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury (Journal article)

Cross, M. J., Berridge, B. R., Clements, P. J. M., Cove-Smith, L., Force, T. L., Hoffmann, P., . . . Park, B. K. (2015). Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury. BRITISH JOURNAL OF PHARMACOLOGY, 172(4), 957-974. doi:10.1111/bph.12979

DOI: 10.1111/bph.12979

Nalmefene in Supporting Alcohol Reduction: Observations from a Clinical Cohort (Journal article)

Owens, L., Thompson, A., Pirmohamed, M., Gilmore, I., & Richardson, P. (2015). Nalmefene in Supporting Alcohol Reduction: Observations from a Clinical Cohort. Journal of Addiction Medicine and Therapy, 3(1).

A Duplication Copy Number Variation in the Exportin-4 (XPO4) is a Predictor for Histological Severity of Non-Alcoholic Fatty Liver Disease (Journal article)

Zain, S. M., Mohamed, Z., Pirmohamed, M., Tan, H. L., & Mohamed, R. (2015). A Duplication Copy Number Variation in the Exportin-4 (XPO4) is a Predictor for Histological Severity of Non-Alcoholic Fatty Liver Disease. PUBLIC HEALTH GENOMICS, 18, 27. Retrieved from http://gateway.webofknowledge.com/

Oral anticoagulation: a critique of recent advances and controversies (Journal article)

Pirmohamed, M., Kamali, F., Daly, A. K., & Wadelius, M. (2015). Oral anticoagulation: a critique of recent advances and controversies. TRENDS IN PHARMACOLOGICAL SCIENCES, 36(3), 153-163. doi:10.1016/j.tips.2015.01.003

DOI: 10.1016/j.tips.2015.01.003

Pharmacogenetics of Adverse Drug Reactions (Chapter)

Turner, R. M., & Pirmohamed, M. (2015). Pharmacogenetics of Adverse Drug Reactions. In Advances in Predictive, Preventive and Personalised Medicine (pp. 109-156). Springer International Publishing. doi:10.1007/978-3-319-15344-5_6

DOI: 10.1007/978-3-319-15344-5_6

Pharmacogenomics: The Hierarchy of Evidence (Journal article)

Pirmohamed, M. (2015). Pharmacogenomics: The Hierarchy of Evidence. PUBLIC HEALTH GENOMICS, 18, 2. Retrieved from http://gateway.webofknowledge.com/

The Influence of Pharmacogenetics on the Time to Acute Coronary Syndrome Recurrence in a UK Cohort Study (Conference Paper)

Yin, P., Jorgensen, A., Morris, A., Turner, R., Fitzgerald, R., Stables, R., . . . Pirmohamed, M. (2015). The Influence of Pharmacogenetics on the Time to Acute Coronary Syndrome Recurrence in a UK Cohort Study. In HUMAN HEREDITY Vol. 80 (pp. 123). Retrieved from http://gateway.webofknowledge.com/

2014

Clinical coding of prospectively identified paediatric adverse drug reactions – a retrospective review of patient records (Journal article)

Bellis, J. R., Kirkham, J. J., Nunn, A. J., & Pirmohamed, M. (2014). Clinical coding of prospectively identified paediatric adverse drug reactions – a retrospective review of patient records. BMC PHARMACOLOGY & TOXICOLOGY, 15. doi:10.1186/2050-6511-15-72

DOI: 10.1186/2050-6511-15-72

A Review of A Priori Regression Models for Warfarin Maintenance Dose Prediction (Journal article)

Francis, B., Lane, S., Pirmohamed, M., & Jorgensen, A. (2014). A Review of A Priori Regression Models for Warfarin Maintenance Dose Prediction. PLoS One, 9(12). doi:10.1371/journal.pone.0114896

DOI: 10.1371/journal.pone.0114896

Pharmacogenetics of warfarin in a paediatric population: time in therapeutic range, initial and stable dosing and adverse effects. (Journal article)

Hawcutt, D., Ghani, A., Sutton, L., Jorgensen, A., Zhang, E., Murray, M., . . . Pirmohamed, M. (2014). Pharmacogenetics of warfarin in a paediatric population: time in therapeutic range, initial and stable dosing and adverse effects.. The Pharmacogenomics Journal, 14(6), 542-548. doi:10.1038/tpj.2014.31

DOI: 10.1038/tpj.2014.31

CYP2B6 c.983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations (Journal article)

Carr, D. F., Chaponda, M., Cornejo Castro, E. M., Jorgensen, A. L., Khoo, S., Van Oosterhout, J. J., . . . Pirmohamed, M. (2014). CYP2B6 c.983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations. Journal of Antimicrobial Chemotherapy, 69(12), 3329-3334. doi:10.1093/jac/dku315

DOI: 10.1093/jac/dku315

Dual Glutathione-S-Transferase-theta 1 and -mu 1 Gene Deletions Determine Imatinib Failure in Chronic Myeloid Leukemia (Journal article)

Davies, A., Giannoudis, A., Zhang, J. E., Austin, G., Wang, L., Holyoake, T. L., . . . Clark, R. E. (2014). Dual Glutathione-S-Transferase-theta 1 and -mu 1 Gene Deletions Determine Imatinib Failure in Chronic Myeloid Leukemia. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(6), 694-703. doi:10.1038/clpt.2014.176

DOI: 10.1038/clpt.2014.176

Pharmacogenomic signatures of response to etanercept therapy for psoriasis (Conference Paper)

Foulkes, A. C., Carr, D. F., Al-Sharqi, A., Parslew, R., Pirmohamed, M., Reynolds, N. J., . . . Warren, R. B. (2014). Pharmacogenomic signatures of response to etanercept therapy for psoriasis. In BRITISH JOURNAL OF DERMATOLOGY Vol. 171 (pp. E114-E115). Retrieved from http://gateway.webofknowledge.com/

Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children (Journal article)

McWilliam, S. J., Antoine, D. J., Sabbisetti, V. S., Pearce, R. E., Jorgensen, A. L., Lin, Y., . . . Pirmohamed, M. (2014). Reference intervals for urinary renal injury biomarkers KIM-1 and NGAL in healthy children. Biomarkers in Medicine, 8(10), 1189-1197. doi:10.2217/bmm.14.36

DOI: 10.2217/bmm.14.36

Validation of a multigenic model to predict seizure control in newly treated epilepsy (Journal article)

Shazadi, K., Petrovski, P., Roten, A., Miller, H., Huggins, R. M., Brodie, M. J., . . . Sills, G. (2014). Validation of a multigenic model to predict seizure control in newly treated epilepsy. Epilepsy Research, 108(10), 1797-1805. doi:10.1016/j.eplepsyres.2014.08.022

DOI: 10.1016/j.eplepsyres.2014.08.022

Genotype-Guided Vitamin K Antagonist Dosing Algorithms Improve Time in Therapeutic Range: A Systematic Review and Meta-Analysis (Conference Paper)

BeIley-Cote, E. P., Hanif, H., D'Aragon, F., Eikelboom, J., Anderson, J. L., Borgman, M., . . . Whitlock, R. (2014). Genotype-Guided Vitamin K Antagonist Dosing Algorithms Improve Time in Therapeutic Range: A Systematic Review and Meta-Analysis. In CIRCULATION Vol. 130. Retrieved from http://gateway.webofknowledge.com/

Serum Mannose-Binding Lectin Concentration, but Not Genotype, Is Associated With Clostridium difficile Infection Recurrence: A Prospective Cohort Study (Journal article)

Swale, A., Miyajima, F., Kolamunnage-Dona, R., Roberts, P., Little, M., Beeching, N., . . . Pirmohamed, M. (2014). Serum Mannose-Binding Lectin Concentration, but Not Genotype, Is Associated With Clostridium difficile Infection Recurrence: A Prospective Cohort Study. Clinical Infectious Diseases, 59(10), 1429-1436. doi:10.1093/cid/ciu666

DOI: 10.1093/cid/ciu666

Through a Glass Darkly: Economics and Personalised Medicine (Journal article)

Haycox, A., Pirmohamed, M., McLeod, C., Houten, R., & Richards, S. (2014). Through a Glass Darkly: Economics and Personalised Medicine. PharmacoEconomics, 32(11), 1055-1061. doi:10.1007/s40273-014-0190-6

DOI: 10.1007/s40273-014-0190-6

A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine (Journal article)

Raedisch, S., Dickens, D., Lang, T., Bonnett, L., Arlanov, R., Johnson, M. R., . . . Pirmohamed, M. (2014). A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine. PHARMACOGENOMICS JOURNAL, 14(5), 481-487. doi:10.1038/tpj.2014.5

DOI: 10.1038/tpj.2014.5

Phenotype Standardization for Statin-Induced Myotoxicity (Journal article)

Alfirevic, A., Neely, D., Armitage, J., Chinoy, H., Cooper, R. G., Laaksonen, R., . . . Pirmohamed, M. (2014). Phenotype Standardization for Statin-Induced Myotoxicity. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(4), 470-476. doi:10.1038/clpt.2014.121

DOI: 10.1038/clpt.2014.121

Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System (Journal article)

Wadelius, M., Marshall, S. E., Islander, G., Nordang, L., Karawajczyk, M., Yue, Q. -Y., . . . Palmer, C. N. A. (2014). Phenotype Standardization of Angioedema in the Head and Neck Region Caused by Agents Acting on the Angiotensin System. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(4), 477-481. doi:10.1038/clpt.2014.138

DOI: 10.1038/clpt.2014.138

WHICH GENETIC PATHWAYS UNDERLIE PHARMACORESISTANT EPILEPSY? (Conference Paper)

Mirza, N., Jorgensen, A., Sills, G., Johnson, M., Pirmohamed, M., & Marson, T. (2014). WHICH GENETIC PATHWAYS UNDERLIE PHARMACORESISTANT EPILEPSY?. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 85. doi:10.1136/jnnp-2014-309236.6

DOI: 10.1136/jnnp-2014-309236.6

Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011 (Journal article)

Thomas, K. H., Martin, R. M., Potokar, J., Pirmohamed, M., & Gunnell, D. (2014). Reporting of drug induced depression and fatal and non-fatal suicidal behaviour in the UK from 1998 to 2011. BMC PHARMACOLOGY & TOXICOLOGY, 15. doi:10.1186/2050-6511-15-54

DOI: 10.1186/2050-6511-15-54

GATM gene variants and statin myopathy risk (Journal article)

Carr, D., Alfirevic, A., Johnson, R., Chinoy, H., van Staa, T., & Pirmohamed, M. (2014). GATM gene variants and statin myopathy risk. Nature, 513(7518). doi:10.1038/nature13628

DOI: 10.1038/nature13628

Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles (Journal article)

Goldstein, J. I., Jarskog, L. F., Hilliard, C., Alfirevic, A., Duncan, L., Fourches, D., . . . Sullivan, P. F. (2014). Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles. Nature Communications, 5. doi:10.1038/ncomms5757

DOI: 10.1038/ncomms5757

Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy (vol 96, pg 15, 2014) (Journal article)

Maitland-van der Zee, A. H., Daly, A. K., Kamali, F., Manolopoulous, V. G., Verhoef, T. I., Wadelius, M., . . . Pirmohamed, M. (2014). Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy (vol 96, pg 15, 2014). CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(3), 397. Retrieved from http://gateway.webofknowledge.com/

Personalized Pharmacogenomics: Predicting Efficacy and Adverse Drug Reactions (Journal article)

Pirmohamed, M. (2014). Personalized Pharmacogenomics: Predicting Efficacy and Adverse Drug Reactions. ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, VOL 15, 15, 349-370. doi:10.1146/annurev-genom-090413-025419

DOI: 10.1146/annurev-genom-090413-025419

Calprotectin and Lactoferrin Faecal Levels in Patients with Clostridium difficile Infection (CDI): A Prospective Cohort Study (Journal article)

Swale, A., Miyajima, F., Roberts, P., Hall, A., Little, M., Beadsworth, M., . . . Pirmohamed, M. (2014). Calprotectin and Lactoferrin Faecal Levels in Patients with Clostridium difficile Infection (CDI): A Prospective Cohort Study. PLoS One, 9(8). doi:10.1371/journal.pone.0106118

DOI: 10.1371/journal.pone.0106118

Predictors and outcomes of increases in creatine phosphokinase concentrations or rhabdomyolysis risk during statin treatment (Journal article)

van Staa, T. P., Carr, D. F., O'Meara, H., McCann, G., & Pirmohamed, M. (2014). Predictors and outcomes of increases in creatine phosphokinase concentrations or rhabdomyolysis risk during statin treatment. British Journal of Clinical Pharmacology, 78(3), 649-659. doi:10.1111/bcp.12367

DOI: 10.1111/bcp.12367

Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation. (Journal article)

Bedson, E., Bell, D., Carr, D., Carter, B., Hughes, D., Jorgensen, A., . . . Williams, N. (2014). Folate Augmentation of Treatment--Evaluation for Depression (FolATED): randomised trial and economic evaluation.. Health Technology Assessment, 18(48). doi:10.3310/hta18480

DOI: 10.3310/hta18480

Abs No: HLA-A*31:01 positive hypersensitive patient (Journal article)

Lichtenfels, M., Farrell, J., Ogese, M., Bell, C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). Abs No: HLA-A*31:01 positive hypersensitive patient. Clinical and translational allergy, 4(Suppl 3), P117. doi:10.1186/2045-7022-4-s3-p117

DOI: 10.1186/2045-7022-4-s3-p117

Antigen exposure required for T cell activation (Journal article)

Meng, X., Yaseen, F., Earnshaw, C., Jenkins, R., Peckham, D., Whitaker, P., . . . Park, K. (2014). Antigen exposure required for T cell activation. Clinical and translational allergy, 4(Suppl 3), P115. doi:10.1186/2045-7022-4-s3-p115

DOI: 10.1186/2045-7022-4-s3-p115

CYP2B618 is associated with nevirpine hypersensitivity independently of HLA-C04:01 in a Malawian HIV population (Journal article)

Carr, D., Chaponda, M., Castro, E. C., Jorgensen, A., Khoo, S., & Pirmohamed, M. (2014). CYP2B6*18 is associated with nevirpine hypersensitivity independently of HLA-C*04:01 in a Malawian HIV population. Clinical and translational allergy, 4(Suppl 3), P126. doi:10.1186/2045-7022-4-s3-p126

DOI: 10.1186/2045-7022-4-s3-p126

Characterization of amoxicillin and clavulanic-acid-responsive CD4+ And CD8+ T-cells in patients with co-amoxiclav-induced liver injury (Journal article)

Kim, S. -H., Saide, K., Yuan, Y., Daly, A., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. (2014). Characterization of amoxicillin and clavulanic-acid-responsive CD4+ And CD8+ T-cells in patients with co-amoxiclav-induced liver injury. Clinical and translational allergy, 4(Suppl 3), P42. doi:10.1186/2045-7022-4-s3-p42

DOI: 10.1186/2045-7022-4-s3-p42

Establishment of an HLA-typed cohort of 1000 healthy blood donors and use of a dendritic cell priming assay to prime naive T cells to structurally divergent drugs (Journal article)

Faulkner, L., Wood, S., Van Eker, D., Alfirevic, A., Pirmohamed, M., Naisbitt, D., & Park, K. (2014). Establishment of an HLA-typed cohort of 1000 healthy blood donors and use of a dendritic cell priming assay to prime naive T cells to structurally divergent drugs. Clinical and translational allergy, 4(Suppl 3), P112. doi:10.1186/2045-7022-4-s3-p112

DOI: 10.1186/2045-7022-4-s3-p112

Genome-wide association study of nevirapine hypersensitivity in a malawian HIV-infected population (Journal article)

Carr, D., Bourgeois, S., Chaponda, M., Castro, E. C., Deloukas, P., & Pirmohamed, M. (2014). Genome-wide association study of nevirapine hypersensitivity in a malawian HIV-infected population. Clinical and translational allergy, 4(Suppl 3), P125. doi:10.1186/2045-7022-4-s3-p125

DOI: 10.1186/2045-7022-4-s3-p125

HLA-DQ restricted activation of nitroso-sulfamethoxazole-specific CD4+ T-lymphocytes (Journal article)

Ogese, M., Saide, K., Whitaker, P., Peckham, D., Faulkner, L., Alfirevic, A., . . . Naisbitt, D. (2014). HLA-DQ restricted activation of nitroso-sulfamethoxazole-specific CD4+ T-lymphocytes. Clinical and translational allergy, 4(Suppl 3), P110. doi:10.1186/2045-7022-4-s3-p110

DOI: 10.1186/2045-7022-4-s3-p110

Identification of susceptible HLA class II co-amoxiclav genotypes based on the analysis of drug-specific T-cells from patients with liver injury (Journal article)

Saide, K., Kim, S. -H., Yuan, Y., Daly, A., Alfirevic, A., Pirmohamed, M., . . . Naisbitt, D. (2014). Identification of susceptible HLA class II co-amoxiclav genotypes based on the analysis of drug-specific T-cells from patients with liver injury. Clinical and translational allergy, 4(Suppl 3), O3. doi:10.1186/2045-7022-4-s3-o3

DOI: 10.1186/2045-7022-4-s3-o3

Skewing of the TCR V repertoire in SMX-NO specific T cell responses (Journal article)

Faulkner, L., Lichtenfels, M., Esser, P., Martin, S., Alfirevic, A., Pirmohamed, M., . . . Park, K. (2014). Skewing of the TCR V repertoire in SMX-NO specific T cell responses. Clinical and translational allergy, 4(Suppl 3), P114. doi:10.1186/2045-7022-4-s3-p114

DOI: 10.1186/2045-7022-4-s3-p114

Assessing the reliability of exome sequencing to detect the filaggrin null mutations R501X and 2282del4 (Conference Paper)

Thompson, B., Hawcutt, D., Carr, D., Bloch, K., Swale, A., Smyth, R., & Pirmohamed, M. (2014). Assessing the reliability of exome sequencing to detect the filaggrin null mutations R501X and 2282del4. In BRITISH JOURNAL OF DERMATOLOGY Vol. 171 (pp. 115-116). Retrieved from http://gateway.webofknowledge.com/

Dexamethasone and haemorrhage risk in paediatric tonsillectomy: a systematic review and meta-analysis (Journal article)

Bellis, J., Pirmohamed, M., Nunn, A. J., Loke, Y. K., De, S., Golder, S., & Kirkham, J. J. (2014). Dexamethasone and haemorrhage risk in paediatric tonsillectomy: a systematic review and meta-analysis. British Journal of Anaesthesia, 113(1), 23-42. doi:10.1093/bja/aeu152

DOI: 10.1093/bja/aeu152

Mechanisms of Adverse Drug Reactions (Chapter)

Pirmohamed, M. (n.d.). Mechanisms of Adverse Drug Reactions. In Mann's Pharmacovigilance (pp. 463-487). John Wiley & Sons, Ltd. doi:10.1002/9781118820186.ch30

DOI: 10.1002/9781118820186.ch30

Is the Interleukin 8 Promoter Polymorphism rs4073/–251T >A Associated With Clostridium difficile Infection? (Journal article)

Miyajima, F., Swale, A., Zhang, E., Alfirevic, A., Little, M., Beeching, N., . . . Pirmohamed, M. (2014). Is the Interleukin 8 Promoter Polymorphism rs4073/–251T >A Associated With Clostridium difficile Infection?. Clinical Infectious Disease, 58(12), e148-e151. doi:10.1093/cid/ciu152

DOI: 10.1093/cid/ciu152

Hemolytic anemia in two patients with glioblastoma multiforme: A possible interaction between vorinostat and dapsone (Journal article)

Lewis, J. A., Petty, W. J., Harmon, M., Peacock, J. E., Valente, K., Owen, J., . . . Lesser, G. J. (2015). Hemolytic anemia in two patients with glioblastoma multiforme: A possible interaction between vorinostat and dapsone. JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 21(3), 220-223. doi:10.1177/1078155214524085

DOI: 10.1177/1078155214524085

BACLOFEN AS AN ADJUNCT PHARMACOTHERAPY FOR THE MAINTENANCE OF ABSTINENCE IN ALCOHOL DEPENDENT PATIENTS WITH LIVER DISEASE (Conference Paper)

Owens, L., Richardson, P., Pirmohamed, M., & Rose, A. (2014). BACLOFEN AS AN ADJUNCT PHARMACOTHERAPY FOR THE MAINTENANCE OF ABSTINENCE IN ALCOHOL DEPENDENT PATIENTS WITH LIVER DISEASE. In GUT Vol. 63 (pp. A90-A91). doi:10.1136/gutjnl-2014-307263.192

DOI: 10.1136/gutjnl-2014-307263.192

IDENTIFYING THE CAUSES OF PHARMACORESISTANT EPILEPSY THROUGH A GENOME-WIDE ASSOCIATION STUDY WITH PATHWAY AND NETWORK ANALYSIS: FROM COMPLEXITY TO COHERENCE TO CENTRALITY (Conference Paper)

Mirza, N., Jorgensen, A., Sills, G., Johnson, M., Pirmohamed, M., & Marson, A. G. (2014). IDENTIFYING THE CAUSES OF PHARMACORESISTANT EPILEPSY THROUGH A GENOME-WIDE ASSOCIATION STUDY WITH PATHWAY AND NETWORK ANALYSIS: FROM COMPLEXITY TO COHERENCE TO CENTRALITY. In EPILEPSIA Vol. 55 (pp. 10). Retrieved from http://gateway.webofknowledge.com/

Pharmacogenomics: Current State-of-the-Art (Journal article)

Carr, D. F., Alfirevic, A., & Pirmohamed, M. (2014). Pharmacogenomics: Current State-of-the-Art. GENES, 5(2), 430-443. doi:10.3390/genes5020430

DOI: 10.3390/genes5020430

Adverse Drug Reactions (Chapter)

Walker, L., Yip, V., & Pirmohamed, M. (2014). Adverse Drug Reactions. In Handbook of Pharmacogenomics and Stratified Medicine (pp. 405-435). Elsevier. doi:10.1016/b978-0-12-386882-4.00020-7

DOI: 10.1016/b978-0-12-386882-4.00020-7

Genotype-Guided Dosing of Vitamin K Antagonists (Journal article)

Daneshjou, R., Klein, T. E., & Altman, R. B. (2014). Genotype-Guided Dosing of Vitamin K Antagonists. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1762-1763. Retrieved from http://gateway.webofknowledge.com/

Genotype-Guided Dosing of Vitamin K Antagonists (Journal article)

Cavallari, L. H., Kittles, R. A., & Perera, M. A. (2014). Genotype-Guided Dosing of Vitamin K Antagonists. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1763. Retrieved from http://gateway.webofknowledge.com/

Genotype-Guided Dosing of Vitamin K Antagonists (Journal article)

Koller, E. A., Roche, J. C., & Rollins, J. A. (2014). Genotype-Guided Dosing of Vitamin K Antagonists. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1761. Retrieved from http://gateway.webofknowledge.com/

Genotype-Guided Dosing of Vitamin K Antagonists (Journal article)

Schwarz, U. I., Kim, R. B., & Tirona, R. G. (2014). Genotype-Guided Dosing of Vitamin K Antagonists. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1761-1762. Retrieved from http://gateway.webofknowledge.com/

Genotype-Guided Dosing of Vitamin K Antagonists (Journal article)

Pereira, N. L., Rihal, C. S., & Weinshilboum, R. M. (2014). Genotype-Guided Dosing of Vitamin K Antagonists. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1762. Retrieved from http://gateway.webofknowledge.com/

Genotype-Guided Dosing of Vitamin K Antagonists REPLY (Journal article)

Maitland-van der Zee, A. H., de Boer, A., Manolopoulos, V. G., & Grp, E. U. -P. A. C. T. (2014). Genotype-Guided Dosing of Vitamin K Antagonists REPLY. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1765-1766. Retrieved from http://gateway.webofknowledge.com/

Genotype-Guided Dosing of Vitamin K Antagonists REPLY (Journal article)

Kimmel, S. E., French, B., Geller, N. L., & Investigators, C. O. A. G. (2014). Genotype-Guided Dosing of Vitamin K Antagonists REPLY. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1763-1764. Retrieved from http://gateway.webofknowledge.com/

Genotype-Guided Dosing of Vitamin K Antagonists REPLY (Journal article)

Pirmohamed, M., Wadelius, M., Kamali, F., & Grp, E. U. -P. A. C. T. (2014). Genotype-Guided Dosing of Vitamin K Antagonists REPLY. NEW ENGLAND JOURNAL OF MEDICINE, 370(18), 1764-1765. Retrieved from http://gateway.webofknowledge.com/

Genotype-guided dosing of vitamin K antagonists. (Journal article)

Pereira, N. L., Rihal, C. S., & Weinshilboum, R. M. (2014). Genotype-guided dosing of vitamin K antagonists.. The New England journal of medicine, 370(18), 1762. doi:10.1056/nejmc1402521

DOI: 10.1056/nejmc1402521

Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality (Conference Paper)

Mirza, N., Sills, G., Jorgensen, A., Johnson, M., Pirmohamed, M., & Marson, A. G. (2014). Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality. In JOURNAL OF NEUROLOGY Vol. 261 (pp. S484-S485). Retrieved from http://gateway.webofknowledge.com/

Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality (Conference Paper)

Mirza, N., Sills, G., Jorgensen, A., Johnson, M., Pirmohamed, M., & Marson, A. G. (2014). Identifying the causes of pharmacoresistant epilepsy through a genome-wide association study with pathway and network analysis: from complexity to coherence to centrality. In EUROPEAN JOURNAL OF NEUROLOGY Vol. 21 (pp. 755). Retrieved from http://gateway.webofknowledge.com/

Electronic Health Records For Biological Sample Collection: Feasibility Study Of Statin-Induced Myopathy Using The Clinical Practice Research Datalink (Journal article)

O'Meara, H., Carr, D. F., Evely, J., Hobbs, M., McCann, G., Van Staa, T., & Pirmohamed, M. (2014). Electronic Health Records For Biological Sample Collection: Feasibility Study Of Statin-Induced Myopathy Using The Clinical Practice Research Datalink. British Journal of Clinical Pharmacology, 77(5), 831-838. doi:10.1111/bcp.12269

DOI: 10.1111/bcp.12269

F-19 NMR Reveals Multiple Conformations at the Dimer Interface of the Nonstructural Protein 1 Effector Domain from Influenza A Virus (Journal article)

Aramini, J. M., Hamilton, K., Ma, L. -C., Swapna, G. V. T., Leonard, P. G., Ladbury, J. E., . . . Montelione, G. T. (2014). F-19 NMR Reveals Multiple Conformations at the Dimer Interface of the Nonstructural Protein 1 Effector Domain from Influenza A Virus. STRUCTURE, 22(4), 515-525. doi:10.1016/j.str.2014.01.010

DOI: 10.1016/j.str.2014.01.010

In AF or VTE, warfarin dosing by genotype improved time in therapeutic range but not clinical outcomes (Journal article)

Pirmohamed, M., Burnside, G., & Eriksson, N. (2014). In AF or VTE, warfarin dosing by genotype improved time in therapeutic range but not clinical outcomes. ANNALS OF INTERNAL MEDICINE, 160(6). doi:10.7326/0003-4819-160-6-201403180-02009

DOI: 10.7326/0003-4819-160-6-201403180-02009

Cardiovascular Pharmacogenomics: Expectations and Practical Benefits (Journal article)

Turner, R. M., & Pirmohamed, M. (2014). Cardiovascular Pharmacogenomics: Expectations and Practical Benefits. CLINICAL PHARMACOLOGY & THERAPEUTICS, 95(3), 281-293. doi:10.1038/clpt.2013.234

DOI: 10.1038/clpt.2013.234

Covalent adduction of carbamazepine 10, 11-epoxide with human serum albumin and glutathione S-transferase pi: implications for carbamazepine hypersensitivity (Journal article)

Yip, V., Maggs, J., Meng, X., Marson, A., Park, K., & Pirmohamed, M. (2014). Covalent adduction of carbamazepine 10, 11-epoxide with human serum albumin and glutathione S-transferase pi: implications for carbamazepine hypersensitivity. LANCET, 383, 114. Retrieved from http://gateway.webofknowledge.com/

High mobility group box 1 in the inflammatory pathogenesis of epilepsy: profiling circulating levels after experimental and clinical seizures (Journal article)

Walker, L., Tse, K., Ricci, E., Thippeswamy, T., Sills, G. J., White, S. H., . . . Pirmohamed, M. (2014). High mobility group box 1 in the inflammatory pathogenesis of epilepsy: profiling circulating levels after experimental and clinical seizures. LANCET, 383, 105. Retrieved from http://gateway.webofknowledge.com/

Treatment of paracetamol overdose: room for improvement? (Journal article)

Park, K., Antoine, D. J., & Pirmohamed, M. (2014). Treatment of paracetamol overdose: room for improvement?. LANCET, 383(9918), 672-674. doi:10.1016/S0140-6736(13)62303-X

DOI: 10.1016/S0140-6736(13)62303-X

Adverse drug reactions and off-label and unlicensed medicines in children: a prospective cohort study of unplanned admissions to a paediatric hospital (Journal article)

Bellis, J. R., Kirkham, J. J., Nunn, A. J., & Pirmohamed, M. (2014). Adverse drug reactions and off-label and unlicensed medicines in children: a prospective cohort study of unplanned admissions to a paediatric hospital. British Journal of Clinical Pharmacology, 77(3), 545-553. doi:10.1111/bcp.12222

DOI: 10.1111/bcp.12222

HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient (Journal article)

Lichtenfels, M., Farrell, J., Ogese, M. O., Bell, C. C., Eckle, S., McCluskey, J., . . . Pirmohamed, M. (2014). HLA restriction of carbamazepine-specific T-cell clones from an HLA-A*31:01-positive hypersensitive patient. Chemical Research in Toxicology, 27(02), 175-177. doi:10.1021/tx400460w

DOI: 10.1021/tx400460w

Cost-effectiveness of pharmacogenetic guided warfarin therapy versus alternative anticoagulation in atrial fibrillation (Journal article)

Pink, J., Pirmohamed, M., Lane, S., & Hughes, D. A. (2014). Cost-effectiveness of pharmacogenetic guided warfarin therapy versus alternative anticoagulation in atrial fibrillation. Clinical Pharmacology and Therapeutics, 95(2), 199-207. doi:10.1038/clpt.2013.190

DOI: 10.1038/clpt.2013.190

Population Pharmacokinetic and Pharmacogenetic Analysis of Nevirapine in Hypersensitive and Tolerant HIV-Infected Patients from Malawi (Journal article)

Dickinson, L., Chaponda, M., Carr, D. F., van Oosterhout, J. J., Kumwenda, J., Lalloo, D. G., . . . Khoo, S. H. (2014). Population Pharmacokinetic and Pharmacogenetic Analysis of Nevirapine in Hypersensitive and Tolerant HIV-Infected Patients from Malawi. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 58(2), 706-712. doi:10.1128/AAC.02069-13

DOI: 10.1128/AAC.02069-13

Statins, Immunomodulation, and Infections: A Complex and Unresolved Relationship (Journal article)

Pirmohamed, M. (2014). Statins, Immunomodulation, and Infections: A Complex and Unresolved Relationship. CLINICAL INFECTIOUS DISEASES, 58(3), 357-358. doi:10.1093/cid/cit751

DOI: 10.1093/cid/cit751

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy (Journal article)

Speed, D., Hoggart, C., Petrovski, S., Tachmazidou, I., Coffey, A., Jorgensen, A., . . . Johnson, M. R. (2014). A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy. Human Molecular Genetics, 23(1), 247-258. doi:10.1093/hmg/ddt403

DOI: 10.1093/hmg/ddt403

A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy (Journal article)

DOI: 10.1093/hmg/ddt403

CLINICAL PHARMACOGENOMICS (Conference Paper)

Pirmohamed, M. (2014). CLINICAL PHARMACOGENOMICS. In DRUG METABOLISM REVIEWS Vol. 45 (pp. 4). Retrieved from http://gateway.webofknowledge.com/

Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing: 2014 Update (Journal article)

Martin, M. A., Hoffman, J. M., Freimuth, R. R., Klein, T. E., Dong, B. J., Pirmohamed, M., . . . Kroetz, D. L. (2014). Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing: 2014 Update. CLINICAL PHARMACOLOGY & THERAPEUTICS, 95(5), 499-500. doi:10.1038/clpt.2014.38

DOI: 10.1038/clpt.2014.38

Corrigendum: Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy (Journal article)

Corrigendum: Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy (2014). Clinical Pharmacology & Therapeutics, 96(3), 397. doi:10.1038/clpt.2014.142

DOI: 10.1038/clpt.2014.142

Development of predictive genetic tests for improving the safety of new medicines: the utilization of routinely collected electronic health records (Journal article)

Wing, K., Douglas, I., Bhaskaran, K., Klungel, O. H., Reynolds, R. F., Pirmohamed, M., . . . van Staa, T. P. (2014). Development of predictive genetic tests for improving the safety of new medicines: the utilization of routinely collected electronic health records. DRUG DISCOVERY TODAY, 19(4), 361-366. doi:10.1016/j.drudis.2013.11.003

DOI: 10.1016/j.drudis.2013.11.003

N-acetyltransferase 2 (NAT2) genotype as a risk factor for development of drug-induced liver injury relating to antituberculosis drug treatment in a mixed-ethnicity patient group (Journal article)

Ng, C. -S., Hasnat, A., Al Maruf, A., Ahmed, M. U., Pirmohamed, M., Day, C. P., . . . Daly, A. K. (2014). N-acetyltransferase 2 (NAT2) genotype as a risk factor for development of drug-induced liver injury relating to antituberculosis drug treatment in a mixed-ethnicity patient group. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 70(9), 1079-1086. doi:10.1007/s00228-014-1703-0

DOI: 10.1007/s00228-014-1703-0

Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy (Journal article)

Maitland-van der Zee, A. H., Daly, A. K., Kamali, F., Manolopoulous, V. G., Verhoef, T. I., Wadelius, M., . . . Grp, E. U. -P. A. C. T. S. (2014). Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy. CLINICAL PHARMACOLOGY & THERAPEUTICS, 96(1), 15-17. doi:10.1038/clpt.2014.44

DOI: 10.1038/clpt.2014.44

Pharmacogenetics in the treatment of chronic lymphocytic leukemia: what does the future hold? (Journal article)

Johnson, G. G., Carr, D. F., Pirmohamed, M., & Pettitt, A. R. (2014). Pharmacogenetics in the treatment of chronic lymphocytic leukemia: what does the future hold?. PHARMACOGENOMICS, 15(7), 897-900. doi:10.2217/pgs.14.60

DOI: 10.2217/pgs.14.60

Pharmacogenetics of antiepileptic drug-induced hypersensitivity (Journal article)

Bloch, K. M., Sills, G. J., Pirmohamed, M., & Alfirevic, A. (2014). Pharmacogenetics of antiepileptic drug-induced hypersensitivity. PHARMACOGENOMICS, 15(6), 857-868. doi:10.2217/PGS.14.65

DOI: 10.2217/PGS.14.65

Quantification of Urinary Mevalonic Acid as a Biomarker of HMG-CoA Reductase Activity by a Novel Translational LC-MS/MS Method (Journal article)

Rodrigues, A. V. M., Maggs, J. L., McWilliam, S. J., Pirmohamed, M., Coen, M., Wilson, I. D., . . . Antoine, D. J. (2014). Quantification of Urinary Mevalonic Acid as a Biomarker of HMG-CoA Reductase Activity by a Novel Translational LC-MS/MS Method. Bioanalysis, 6(7), 919-933. doi:10.4155/bio.13.350

DOI: 10.4155/bio.13.350

The clinical significance of ABCC3 as an imatinib transporter in chronic myeloid leukaemia (Journal article)

Giannoudis, A., Davies, A., Harris, B., Lucas, C., Pirmohamed, M., & Clark, R. (2014). The clinical significance of ABCC3 as an imatinib transporter in chronic myeloid leukaemia. Leukemia, 28(6), 1360-1363. doi:10.1038/leu.2014.38

DOI: 10.1038/leu.2014.38

The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials (Journal article)

The opportunities and challenges of pragmatic point-of-care randomised trials using routinely collected electronic records: evaluations of two exemplar trials (2014). HEALTH TECHNOLOGY ASSESSMENT, 18(43), 1-+. Retrieved from http://gateway.webofknowledge.com/

Thiopurine monitoring in children with inflammatory bowel disease: a systematic review (Journal article)

Konidari, A., Anagnostopoulos, A., Bonnett, L. J., Pirmohamed, M., & El-Matary, W. (2014). Thiopurine monitoring in children with inflammatory bowel disease: a systematic review. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 78(3), 467-476. doi:10.1111/bcp.12365

DOI: 10.1111/bcp.12365

2013

CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia (Journal article)

Johnson, G. G., Lin, K., Cox, T. F., Oates, M., Sibson, D. R., Eccles, R., . . . Pettitt, A. R. (2013). CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia. Blood, 122(26), 4253-4258. doi:10.1182/blood-2013-07-516666

DOI: 10.1182/blood-2013-07-516666

CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia (Journal article)

Johnson, G. G., Lin, K., Cox, T. F., Oates, M., Sibson, D. R., Eccles, R., . . . Pettitt, A. R. (2013). CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia. BLOOD, 122(26), 4253-4258. doi:10.1182/blood-2013-07-516666

DOI: 10.1182/blood-2013-07-516666

Genetic testing for prevention of severe drug-induced skin rash (Journal article)

Alfirevic, A., Pirmohamed, M., Marinovic, B., Jorgensen, A. L., & Harcourt-Smith, L. (n.d.). Genetic testing for prevention of severe drug-induced skin rash. Cochrane Database of Systematic Reviews. doi:10.1002/14651858.cd010891

DOI: 10.1002/14651858.cd010891

A Randomized Trial Comparing Genotype-Guided Dosing of Warfarin to Standard Dosing: The EU Pharmacogenetics of Anticoagulant Therapy (EU-PACT) Warfarin Study (Journal article)

Pirmohamed, M., Burnside, G., Stoddern, J., Prince, C., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial Comparing Genotype-Guided Dosing of Warfarin to Standard Dosing: The EU Pharmacogenetics of Anticoagulant Therapy (EU-PACT) Warfarin Study. CIRCULATION, 128(24), 2710-2711. Retrieved from http://gateway.webofknowledge.com/

A Randomized Trial of Genotype-Guided Dosing of Acenocoumarol and Phenprocoumon (Journal article)

Verhoef, T. I., Ragia, G., de Boer, A., Barallon, R., Kolovou, G., Kolovou, V., . . . Grp, E. U. -P. A. C. T. (2013). A Randomized Trial of Genotype-Guided Dosing of Acenocoumarol and Phenprocoumon. NEW ENGLAND JOURNAL OF MEDICINE, 369(24), 2304-2312. doi:10.1056/NEJMoa1311388

DOI: 10.1056/NEJMoa1311388

A Randomized Trial of Genotype-Guided Dosing of Warfarin (Journal article)

Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., . . . Grp, E. U. -P. A. C. T. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. NEW ENGLAND JOURNAL OF MEDICINE, 369(24), 2294-2303. doi:10.1056/NEJMoa1311386

DOI: 10.1056/NEJMoa1311386

A Randomized Trial of Genotype-Guided Dosing of Warfarin (Journal article)

Pirmohamed, M., Burnside, G., Eriksson, N., Jorgensen, A. L., Toh, C. H., Nicholson, T., . . . Wadelius, M. (2013). A Randomized Trial of Genotype-Guided Dosing of Warfarin. New England Journal of Medicine, 369(24), 2294-2303. doi:10.1056/nejmoa1311386

DOI: 10.1056/nejmoa1311386

SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink (Journal article)

Carr, D. F., O'Meara, H., Jorgensen, A. L., Campbell, J., Hobbs, M., McCann, G., . . . Pirmohamed, M. (2013). SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink. CLINICAL PHARMACOLOGY & THERAPEUTICS, 94(6), 695-701. doi:10.1038/clpt.2013.161

DOI: 10.1038/clpt.2013.161

Adverse drug reactions and off-label and unlicensed medicines in children: a nested case-control study of inpatients in a pediatric hospital (Journal article)

Bellis, J. R., Kirkham, J. J., Thiesen, S., Conroy, E. J., Bracken, L. E., Mannix, H. L., . . . Pirmohamed, M. (2013). Adverse drug reactions and off-label and unlicensed medicines in children: a nested case-control study of inpatients in a pediatric hospital. BMC MEDICINE, 11. doi:10.1186/1741-7015-11-238

DOI: 10.1186/1741-7015-11-238

Incidence, characteristics and risk factors of adverse drug reactions in hospitalized children - a prospective observational cohort study of 6,601 admissions (Journal article)

Thiesen, S., Conroy, E. J., Bellis, J. R., Bracken, L. E., Mannix, H. L., Bird, K. A., . . . Smyth, R. L. (2013). Incidence, characteristics and risk factors of adverse drug reactions in hospitalized children - a prospective observational cohort study of 6,601 admissions. BMC MEDICINE, 11. doi:10.1186/1741-7015-11-237

DOI: 10.1186/1741-7015-11-237

COST EFFECTIVENESS OF PHARMACOGENETIC SCREENING PRIOR TO INITIATION OF CARBAMAZEPINE TREATMENT FOR EPILEPSY (Conference Paper)

Plumpton, C. O., Yip, V., Alfirevic, A., Marson, A., Pirmohamed, M., & Hughes, D. A. (2013). COST EFFECTIVENESS OF PHARMACOGENETIC SCREENING PRIOR TO INITIATION OF CARBAMAZEPINE TREATMENT FOR EPILEPSY. In VALUE IN HEALTH Vol. 16 (pp. A624). doi:10.1016/j.jval.2013.08.1831

DOI: 10.1016/j.jval.2013.08.1831

Defining the role of MicroRNA-122 as a potential circulating biomarker for liver injury and disease (Journal article)

McWhirter, D., Lewis, P. S., Kitteringham, N., Antoine, D., Pirmohamed, M., Goldring, C., . . . Malik, H. (2013). Defining the role of MicroRNA-122 as a potential circulating biomarker for liver injury and disease. BRITISH JOURNAL OF SURGERY, 100, 15-16. Retrieved from http://gateway.webofknowledge.com/

Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Carbamazepine Dosing (Journal article)

Leckband, S. G., Kelsoe, J. R., Dunnenberger, H. M., Jr, G. A. L., Tran, E., Berger, R., . . . Pirmohamed, M. (2013). Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Carbamazepine Dosing. CLINICAL PHARMACOLOGY & THERAPEUTICS, 94(3), 324-328. doi:10.1038/clpt.2013.103

DOI: 10.1038/clpt.2013.103

Anticonvulsant Agents (Chapter)

Pirmohamed, M., & Leeder, J. S. (2013). Anticonvulsant Agents. In Drug-Induced Liver Disease (pp. 423-441). Elsevier. doi:10.1016/b978-0-12-387817-5.00024-8

DOI: 10.1016/b978-0-12-387817-5.00024-8

Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives (Journal article)

Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. Journal of Allergy and Clinical Immunology, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045

DOI: 10.1016/j.jaci.2013.02.045

Comparative Effectiveness of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in the Management of Patients With Nonvalvular Atrial Fibrillation (Journal article)

Pink, J., Pirmohamed, M., & Hughes, D. A. (2013). Comparative Effectiveness of Dabigatran, Rivaroxaban, Apixaban, and Warfarin in the Management of Patients With Nonvalvular Atrial Fibrillation. CLINICAL PHARMACOLOGY & THERAPEUTICS, 94(2), 269-276. doi:10.1038/clpt.2013.83

DOI: 10.1038/clpt.2013.83

Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFN beta interact with the endogenous cytokine and activate complement (Journal article)

Sethu, S., Govindappa, K., Quinn, P., Wadhwa, M., Stebbings, R., Boggild, M., . . . Sathish, J. (2013). Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFN beta interact with the endogenous cytokine and activate complement. CLINICAL IMMUNOLOGY, 148(2), 177-185. doi:10.1016/j.clim.2013.05.008

DOI: 10.1016/j.clim.2013.05.008

The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes (Journal article)

Behr, E. R., January, C., Schulze-Bahr, E., Grace, A. A., Kaeaeb, S., Fiszman, M., . . . Roden, D. (2013). The International Serious Adverse Events Consortium (iSAEC) phenotype standardization project for drug-induced torsades de pointes. EUROPEAN HEART JOURNAL, 34(26), 1958-1963. doi:10.1093/eurheartj/ehs172

DOI: 10.1093/eurheartj/ehs172

Immunomodulatory interventions for focal epilepsy syndromes (Journal article)

Walker, L., Pirmohamed, M., & Marson, A. G. (2013). Immunomodulatory interventions for focal epilepsy syndromes. COCHRANE DATABASE OF SYSTEMATIC REVIEWS, (6). doi:10.1002/14651858.CD009945.pub2

DOI: 10.1002/14651858.CD009945.pub2

beta-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis (Journal article)

Jenkins, R. E., Yaseen, F. S., Monshi, M. M., Whitaker, P., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2013). beta-Lactam Antibiotics Form Distinct Haptenic Structures on Albumin and Activate Drug-Specific T-Lymphocyte Responses in Multiallergic Patients with Cystic Fibrosis. CHEMICAL RESEARCH IN TOXICOLOGY, 26(6), 963-975. doi:10.1021/tx400124m

DOI: 10.1021/tx400124m

TRANSCRIPT LEVELS AND COPY NUMBER VARIATION OF THE ABCC3 EFFLUX TRANSPORTER CAN PREDICT CLINICAL OUTCOME IN IMATINIB-TREATED CHRONIC MYELOID LEUKAEMIA PATIENTS (Conference Paper)

Giannoudis, A., Davies, A., Harris, R., Lucas, C., Pirmohamed, M., & Clark, R. (2013). TRANSCRIPT LEVELS AND COPY NUMBER VARIATION OF THE ABCC3 EFFLUX TRANSPORTER CAN PREDICT CLINICAL OUTCOME IN IMATINIB-TREATED CHRONIC MYELOID LEUKAEMIA PATIENTS. In HAEMATOLOGICA Vol. 98 (pp. 400). Retrieved from http://gateway.webofknowledge.com/

ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein (Journal article)

Dickens, D., Owen, A., Alfirevic, A., & Pirmohamed, M. (2013). ABCB1 single nucleotide polymorphisms (1236C > T, 2677G > T, and 3435C > T) do not affect transport activity of human P-glycoprotein. PHARMACOGENETICS AND GENOMICS, 23(6), 314-323. doi:10.1097/FPC.0b013e328360d10c

DOI: 10.1097/FPC.0b013e328360d10c

Cost-effectiveness of pharmacogenetic-guided dosing of phenprocoumon in atrial fibrillation (Journal article)

Verhoef, T. I., Redekop, W. K., Veenstra, D. L., Thariani, R., Beltman, P. A., van Schie, R. M. F., . . . Grp, E. U. -P. A. C. T. (2013). Cost-effectiveness of pharmacogenetic-guided dosing of phenprocoumon in atrial fibrillation. PHARMACOGENOMICS, 14(8), 869-883. doi:10.2217/PGS.13.74

DOI: 10.2217/PGS.13.74

Expanding Role of Pharmacogenomics in the Management of Cardiovascular Disorders (Journal article)

Yip, V. L. M., & Pirmohamed, M. (2013). Expanding Role of Pharmacogenomics in the Management of Cardiovascular Disorders. AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 13(3), 151-162. doi:10.1007/s40256-013-0024-5

DOI: 10.1007/s40256-013-0024-5

Stroke Pharmacogenetics (Chapter)

Walker, L. E., Stewart, A., & Pirmohamed, M. (2013). Stroke Pharmacogenetics. In Stroke Genetics (pp. 223-297). Springer London. doi:10.1007/978-0-85729-209-4_14

DOI: 10.1007/978-0-85729-209-4_14

Transport of gabapentin by LAT1 (SLC7A5) (Journal article)

Dickens, D., Webb, S. D., Antonyuk, S., Giannoudis, A., Owen, A., Rädisch, S., . . . Pirmohamed, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). Biochemical Pharmacology, 85(11), 1672-1683. doi:10.1016/j.bcp.2013.03.022

DOI: 10.1016/j.bcp.2013.03.022

Transport of gabapentin by LAT1 (SLC7A5) (Journal article)

Dickens, D., Webb, S. D., Antonyuk, S., Giannoudis, A., Owen, A., Raedisch, S., . . . Pirmohamed, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). BIOCHEMICAL PHARMACOLOGY, 85(11), 1672-1683. doi:10.1016/j.bcp.2013.03.022

DOI: 10.1016/j.bcp.2013.03.022

A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp (Journal article)

Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp. PLOS ONE, 8(5). doi:10.1371/journal.pone.0064854

DOI: 10.1371/journal.pone.0064854

Variability of antibiotic prescribing in patients with chronic obstructive pulmonary disease exacerbations: a cohort study (Journal article)

Boggon, R., Hubbard, R., Smeeth, L., Gulliford, M., Cassell, J., Eaton, S., . . . van Staa, T. -P. (2013). Variability of antibiotic prescribing in patients with chronic obstructive pulmonary disease exacerbations: a cohort study. BMC PULMONARY MEDICINE, 13. doi:10.1186/1471-2466-13-32

DOI: 10.1186/1471-2466-13-32

T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms (Journal article)

Bell, C. C., Faulkner, L., Martinsson, K., Farrell, J., Alfirevic, A., Tugwood, J., . . . Park, B. K. (2013). T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms. Chemical Research in Toxicology, 26(5), 759-766. doi:10.1021/tx400060p

DOI: 10.1021/tx400060p

T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms (Journal article)

Bell, C. C., Faulkner, L., Martinsson, K., Farrell, J., Alfirevic, A., Tugwood, J., . . . Park, B. K. (2013). T-Cells from HLA-B*57:01+ Human Subjects Are Activated with Abacavir through Two Independent Pathways and Induce Cell Death by Multiple Mechanisms. CHEMICAL RESEARCH IN TOXICOLOGY, 26(5), 759-766. doi:10.1021/tx400060p

DOI: 10.1021/tx400060p

Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population (Journal article)

Carr, D. F., Chaponda, M., Jorgensen, A. L., Castro, E. C., van Oosterhout, J. J., Khoo, S. H., . . . Pirmohamed, M. (2013). Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population. CLINICAL INFECTIOUS DISEASES, 56(9), 1330-1339. doi:10.1093/cid/cit021

DOI: 10.1093/cid/cit021

Pharmacogenomics of anaphylaxis to neuromuscular blocking agents (Conference Paper)

Fisher, A., Leuwer, M., & Pirmohamed, M. (2013). Pharmacogenomics of anaphylaxis to neuromuscular blocking agents. In BRITISH JOURNAL OF ANAESTHESIA Vol. 110 (pp. 865). Retrieved from http://gateway.webofknowledge.com/

Response to "HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity" (Journal article)

Yip, V. L. M., Pirmohamed, M., & Alfirevic, A. (2013). Response to "HLA Allelic Variants and Carbamazepine-Induced Hypersensitivity". CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(5), 387. doi:10.1038/clpt.2013.5

DOI: 10.1038/clpt.2013.5

Response to "HLA allelic variants and carbamazepine-induced hypersensitivity". (Journal article)

Yip, V., Pirmohamed, M., & Alfirevic, A. (2013). Response to "HLA allelic variants and carbamazepine-induced hypersensitivity".. Clinical Pharmacology and Therapeutics, 93(5), 387.

Systematic review of pharmacogenomics in psoriasis (Conference Paper)

Foulkes, A. C., Jorgensen, A., Pirmohamed, M., Griffiths, C. E., & Warren, R. B. (2013). Systematic review of pharmacogenomics in psoriasis. In JOURNAL OF INVESTIGATIVE DERMATOLOGY Vol. 133 (pp. S88). Retrieved from http://gateway.webofknowledge.com/

Challenges and approaches for the development of safer immunomodulatory biologics (Journal article)

Sathish, J. G., Sethu, S., Bielsky, M. -C., de Haan, L., French, N. S., Govindappa, K., . . . Park, B. K. (2013). Challenges and approaches for the development of safer immunomodulatory biologics. NATURE REVIEWS DRUG DISCOVERY, 12(4), 306-324. doi:10.1038/nrd3974

DOI: 10.1038/nrd3974

LONG-TERM OUTCOMES OF PATIENTS WITH ALCOHOL-RELATED CIRRHOSIS ADMITTED TO A GENERAL INTENSIVE CARE UNIT AT A TERTIARY HOSPITAL IN THE UNITED KINGDOM (Conference Paper)

Musumba, C., Shaw, R., Gao, W., Richardson, P., & Hampshire, P. (2013). LONG-TERM OUTCOMES OF PATIENTS WITH ALCOHOL-RELATED CIRRHOSIS ADMITTED TO A GENERAL INTENSIVE CARE UNIT AT A TERTIARY HOSPITAL IN THE UNITED KINGDOM. In JOURNAL OF HEPATOLOGY Vol. 58 (pp. S224). doi:10.1016/S0168-8278(13)60550-4

DOI: 10.1016/S0168-8278(13)60550-4

Pharmacogenetic analysis of CYP2B6 in the LRF CLL4 trial: the*6 allelic variant is associated with inferior efficacy following fludarabine plus cyclophosphamide (Conference Paper)

Johnson, G. G., Lin, K., Cox, T., Oates, M., Sibson, D. R., Eccles, R., . . . Pettitt, A. R. (2013). Pharmacogenetic analysis of CYP2B6 in the LRF CLL4 trial: the*6 allelic variant is associated with inferior efficacy following fludarabine plus cyclophosphamide. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 161 (pp. 19). Retrieved from http://gateway.webofknowledge.com/

Role of IL18 in HIV lipodystrophy (Conference Paper)

Majid, R., Pushpakom, S., & Pirmohamed, M. (2013). Role of IL18 in HIV lipodystrophy. In HIV MEDICINE Vol. 14 (pp. 40). Retrieved from http://gateway.webofknowledge.com/

The hOCT1 substrate metformin does not alter imatinib, dasatinib or nilotinib uptake into CML cells at clinically relevant concentrations (Journal article)

Francis, S., Giannoudis, A., Pirmohamed, M., & Clark, R. E. (2013). The hOCT1 substrate metformin does not alter imatinib, dasatinib or nilotinib uptake into CML cells at clinically relevant concentrations. BRITISH JOURNAL OF HAEMATOLOGY, 161, 58-59. Retrieved from http://gateway.webofknowledge.com/

What can we learn from parents about enhancing participation in pharmacovigilance? (Journal article)

Arnott, J., Hesselgreaves, H., Nunn, A. J., Peak, M., Pirmohamed, M., Smyth, R. L., . . . Young, B. (2013). What can we learn from parents about enhancing participation in pharmacovigilance?. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 75(4), 1109-1117. doi:10.1111/j.1365-2125.2012.04441.x

DOI: 10.1111/j.1365-2125.2012.04441.x

Paediatric pharmacogenomics: an overview (Journal article)

Hawcutt, D. B., Thompson, B., Smyth, R. L., & Pirmohamed, M. (2013). Paediatric pharmacogenomics: an overview. Archives of Disease in Childhood, 98(3), 232-237. doi:10.1136/archdischild-2012-302852

DOI: 10.1136/archdischild-2012-302852

Paediatric pharmacogenomics: an overview (Journal article)

Hawcutt, D. B., Thompson, B., Smyth, R. L., & Pirmohamed, M. (2013). Paediatric pharmacogenomics: an overview. ARCHIVES OF DISEASE IN CHILDHOOD, 98(3), 232-237. doi:10.1136/archdischild-2012-302852

DOI: 10.1136/archdischild-2012-302852

DRUG-GRAPEFRUIT JUICE INTERACTIONS A more balanced approach to drug-grapefruit juice interactions Reply (Journal article)

Pirmohamed, M. (2013). DRUG-GRAPEFRUIT JUICE INTERACTIONS A more balanced approach to drug-grapefruit juice interactions Reply. BMJ-BRITISH MEDICAL JOURNAL, 346. doi:10.1136/bmj.f1078

DOI: 10.1136/bmj.f1078

CYP2C19*17 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease (Journal article)

Musumba, C. O., Jorgensen, A., Sutton, L., Van Eker, D., Zhang, E., O'Hara, N., . . . Pirmohamed, M. (2013). CYP2C19*17 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease. CLINICAL PHARMACOLOGY & THERAPEUTICS, 93(2), 195-203. doi:10.1038/clpt.2012.215

DOI: 10.1038/clpt.2012.215

Human Leukocyte Antigen (HLA)-B(star)57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury (Journal article)

Monshi, M. M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2013). Human Leukocyte Antigen (HLA)-B(star)57:01-Restricted Activation of Drug-Specific T Cells Provides the Immunological Basis for Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 57(2), 727-739. doi:10.1002/hep.26077

DOI: 10.1002/hep.26077

The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia (Journal article)

Giannoudis, A., Wang, L., Jorgensen, A. L., Xinarianos, G., Davies, A., Pushpakom, S., . . . Clark, R. E. (2013). The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia. BLOOD, 121(4), 628-637. doi:10.1182/blood-2012-01-405035

DOI: 10.1182/blood-2012-01-405035

Drug-grapefruit juice interactions (Journal article)

Pirmohamed, M. (2013). Drug-grapefruit juice interactions. BMJ-BRITISH MEDICAL JOURNAL, 346. doi:10.1136/bmj.f1

DOI: 10.1136/bmj.f1

A multi-system approach assessing the interaction of anticonvulsants with P-gp. (Journal article)

Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A multi-system approach assessing the interaction of anticonvulsants with P-gp.. PloS One, 8(5), e64854.

Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives (Journal article)

Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045

DOI: 10.1016/j.jaci.2013.02.045

Adherence and variability in warfarin dose requirements: assessment in a prospective cohort (Journal article)

Jorgensen, A. L., Hughes, D. A., Hanson, A., van Eker, D., Toh, C. H., Pirmohamed, M., & Williamson, P. R. (2013). Adherence and variability in warfarin dose requirements: assessment in a prospective cohort. PHARMACOGENOMICS, 14(2), 151-163. doi:10.2217/PGS.12.199

DOI: 10.2217/PGS.12.199

Emergence and global spread of epidemic healthcare-associated Clostridium difficile (Journal article)

He, M., Miyajima, F., Roberts, P., Ellison, L., Pickard, D. J., Martin, M. J., . . . Lawley, T. D. (2013). Emergence and global spread of epidemic healthcare-associated Clostridium difficile. NATURE GENETICS, 45(1), 109-U155. doi:10.1038/ng.2478

DOI: 10.1038/ng.2478

Paediatric use of mycophenolate mofetil (Journal article)

Downing, H. J., Pirmohamed, M., Beresford, M. W., & Smyth, R. L. (2013). Paediatric use of mycophenolate mofetil. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 75(1), 45-59. doi:10.1111/j.1365-2125.2012.04305.x

DOI: 10.1111/j.1365-2125.2012.04305.x

Paediatric use of mycophenolate mofetil (Journal article)

Downing, H. J., Pirmohamed, M., Beresford, M. W., & Smyth, R. L. (2013). Paediatric use of mycophenolate mofetil. British Journal of Clinical Pharmacology, 75(1), 45-59. doi:10.1111/j.1365-2125.2012.04305.x

DOI: 10.1111/j.1365-2125.2012.04305.x

Pharmacogenetic tests: the need for a level playing field (Journal article)

Pirmohamed, M., & Hughes, D. A. (2013). Pharmacogenetic tests: the need for a level playing field. NATURE REVIEWS DRUG DISCOVERY, 12(1), 3-4. doi:10.1038/nrd3921

DOI: 10.1038/nrd3921

RXR gene variants are associated with HIV lipodystrophy (Journal article)

Pushpakom, S. P., Owen, A., Back, D. J., & Pirmohamed, M. (2013). RXR gene variants are associated with HIV lipodystrophy. PHARMACOGENETICS AND GENOMICS, 23(8), 438-441. doi:10.1097/FPC.0b013e328362cfc6

DOI: 10.1097/FPC.0b013e328362cfc6

The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK (Journal article)

Alfirevic, A., Carr, D. F., Miyajima, F., Pushpakom, S., Sutton, L., Jorgensen, A. L., & Pirmohamed, M. (2013). The Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool, UK. PHARMACOGENOMICS, 14(8), 861-867. doi:10.2217/PGS.13.73

DOI: 10.2217/PGS.13.73

The hOCT1 single nucleotide polymorphisms M420del and M408V alter imatinib uptake and modify clinical outcome in imatinib treated chronic myeloid leukaemia (Journal article)

Giannoudis, A., Wang, L., Jorgensen, A. L., Xinarianos, G., Davies, A., Pushpakom, S., . . . Clark, R. E. (2013). The hOCT1 single nucleotide polymorphisms M420del and M408V alter imatinib uptake and modify clinical outcome in imatinib treated chronic myeloid leukaemia. Blood, 121, 628-637.

Transport of gabapentin by LAT1 (SLC7A5) (Journal article)

Dickens,, D., Webb,, S. D., Antonyuk,, S., Giannoudis,, A., Owen,, A., RÃ¤disch,, S., . . . Pirmohamed,, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). Biochemical Pharmacology, 85, 1672-1683.

2012

Improved Glycaemia Correlates with Liver Fat Reduction in Obese, Type 2 Diabetes, Patients Given Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists (Journal article)

Cuthbertson, D. J., Irwin, A., Gardner, C. J., Daousi, C., Purewal, T., Furlong, N., . . . Kemp, G. J. (2012). Improved Glycaemia Correlates with Liver Fat Reduction in Obese, Type 2 Diabetes, Patients Given Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists. PLOS ONE, 7(12). doi:10.1371/journal.pone.0050117

DOI: 10.1371/journal.pone.0050117

Adverse Drug Reactions Causing Admission to a Paediatric Hospital (Journal article)

Gallagher, R. M., Mason, J. R., Bird, K. A., Kirkham, J. J., Peak, M., Williamson, P. R., . . . Smyth, R. L. (2012). Adverse Drug Reactions Causing Admission to a Paediatric Hospital. PLOS ONE, 7(12). doi:10.1371/journal.pone.0050127

DOI: 10.1371/journal.pone.0050127

HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review (Journal article)

Yip, V. L., Marson, A. G., Jorgensen, A. L., Pirmohamed, M., & Alfirevic, A. (2012). HLA Genotype and Carbamazepine-Induced Cutaneous Adverse Drug Reactions: A Systematic Review. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(6), 757-765. doi:10.1038/clpt.2012.189

DOI: 10.1038/clpt.2012.189

HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review. (Journal article)

Yip, V., Marson, T., Jorgensen, A., Pirmohamed, M., & Alfirevic, A. (2012). HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review.. Clinical Pharmacology and Therapeutics, 92(6), 757-765.

Impact of the CYP4F2 p.V433M Polymorphism on Coumarin Dose Requirement: Systematic Review and Meta-Analysis (Journal article)

Danese, E., Montagnana, M., Johnson, J. A., Rettie, A. E., Zambon, C. F., Lubitz, S. A., . . . Fava, C. (2012). Impact of the CYP4F2 p.V433M Polymorphism on Coumarin Dose Requirement: Systematic Review and Meta-Analysis. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(6), 746-756. doi:10.1038/clpt.2012.184

DOI: 10.1038/clpt.2012.184

Long-term anticoagulant effects of CYP2C9 and VKORC1 genotypes in phenprocoumon users (Journal article)

Verhoef, T. I., Redekop, W. K., Hegazy, H., de Boer, A., Maitland-van der Zee, A. H., & Grp, E. U. -P. A. C. T. (2012). Long-term anticoagulant effects of CYP2C9 and VKORC1 genotypes in phenprocoumon users. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10(12), 2610-2612. doi:10.1111/jth.12007

DOI: 10.1111/jth.12007

VARIATION AT GLCCI1: ASSOCIATION WITH INCREASED STEROID DOSE BUT NOT ADRENAL SUPPRESSION IN ASTHMATIC CHILDREN (Journal article)

Thompson, B., Hawcutt, D. B., Carr, D. F., Jorgensen, A. L., Smyth, R. L., & Pirmohamed, M. (2012). VARIATION AT GLCCI1: ASSOCIATION WITH INCREASED STEROID DOSE BUT NOT ADRENAL SUPPRESSION IN ASTHMATIC CHILDREN. THORAX, 67, A17. doi:10.1136/thoraxjnl-2012-202678.037

DOI: 10.1136/thoraxjnl-2012-202678.037

Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity (Journal article)

Alfirevic, A., Park, B. K., Pirmohamed, M., & Naisbitt, D. J. (2012). Explanation for HLA-B*57:01-linked immune-mediated abacavir-induced hypersensitivity. PHARMACOGENOMICS, 13(14), 1567-1569. doi:10.2217/PGS.12.146

DOI: 10.2217/PGS.12.146

Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs (Journal article)

Urban, T. J., Shen, Y., Stolz, A., Chalasani, N., Fontana, R. J., Rochon, J., . . . Consort, I. S. A. E. (2012). Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs. PHARMACOGENETICS AND GENOMICS, 22(11), 784-795. doi:10.1097/FPC.0b013e3283589a76

DOI: 10.1097/FPC.0b013e3283589a76

Enhancing Communication about Paediatric Medicines: Lessons from a Qualitative Study of Parents' Experiences of Their Child's Suspected Adverse Drug Reaction (Journal article)

Arnott, J., Hesselgreaves, H., Nunn, A. J., Peak, M., Pirmohamed, M., Smyth, R. L., . . . Young, B. (2012). Enhancing Communication about Paediatric Medicines: Lessons from a Qualitative Study of Parents' Experiences of Their Child's Suspected Adverse Drug Reaction. PLOS ONE, 7(10). doi:10.1371/journal.pone.0046022

DOI: 10.1371/journal.pone.0046022

Immunogenicity to Biologics: Mechanisms, Prediction and Reduction (Journal article)

Sethu, S., Govindappa, K., Alhaidari, M., Pirmohamed, M., Park, K., & Sathish, J. (2012). Immunogenicity to Biologics: Mechanisms, Prediction and Reduction. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 60(5), 331-344. doi:10.1007/s00005-012-0189-7

DOI: 10.1007/s00005-012-0189-7

Characterisation of antidrug antibodies (ADA) against therapeutic interferon beta (Conference Paper)

Govindappa, K., Sethu, S., Wadwa, M., Stebbings, R., Kimber, I., Naisbitt, D. J., . . . Sathish, J. G. (2012). Characterisation of antidrug antibodies (ADA) against therapeutic interferon beta. In IMMUNOLOGY Vol. 137 (pp. 655-656). Retrieved from http://gateway.webofknowledge.com/

Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs (Journal article)

Verhoef, T. I., Redekop, W. K., van Schie, R. M. F., Bayat, S., Daly, A. K., Geitona, M., . . . Grp, E. U. -P. A. C. T. (2012). Cost-effectiveness of pharmacogenetics in anticoagulation: international differences in healthcare systems and costs. PHARMACOGENOMICS, 13(12), 1405-1417. doi:10.2217/PGS.12.124

DOI: 10.2217/PGS.12.124

INVESTIGATION OF ANTIEPILEPTIC DRUG TRANSPORT BY SOLUTE CARRIERS OATP1A2 AND MCT1 (Conference Paper)

Jones, H. L., Dickens, D., Owen, A., Pirmohamed, M., & Sills, G. J. (2012). INVESTIGATION OF ANTIEPILEPTIC DRUG TRANSPORT BY SOLUTE CARRIERS OATP1A2 AND MCT1. In EPILEPSIA Vol. 53 (pp. 101). Retrieved from http://gateway.webofknowledge.com/

Letter: are idiopathic (non-NSAID, non-Helicobacter pylori) ulcers really increasing? Authors' reply (Journal article)

Musumba, C., Hopkins, M., Pritchard, D. M., & Pirmohamed, M. (2012). Letter: are idiopathic (non-NSAID, non-Helicobacter pylori) ulcers really increasing? Authors' reply. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(6), 601-602. doi:10.1111/apt.12001

DOI: 10.1111/apt.12001

Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility (Journal article)

Alfirevic, A., & Pirmohamed, M. (2012). Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical Utility. CLINICAL PHARMACOLOGY & THERAPEUTICS, 92(3), 376-380. doi:10.1038/clpt.2012.107

DOI: 10.1038/clpt.2012.107

Influence of CYP2C9 and VKORC1 on Patient Response to Warfarin: A Systematic Review and Meta-Analysis (Journal article)

Jorgensen, A. L., FitzGerald, R. J., Oyee, J., Pirmohamed, M., & Williamson, P. R. (2012). Influence of CYP2C9 and VKORC1 on Patient Response to Warfarin: A Systematic Review and Meta-Analysis. PLOS ONE, 7(8). doi:10.1371/journal.pone.0044064

DOI: 10.1371/journal.pone.0044064

Mechanism-Based Urinary Biomarkers to Identify the Potential for Aminoglycoside-Induced Nephrotoxicity in Premature Neonates: A Proof-of-Concept Study (Journal article)

McWilliam, S. J., Antoine, D. J., Sabbisetti, V., Turner, M. A., Farragher, T., Bonventre, J. V., . . . Pirmohamed, M. (2012). Mechanism-Based Urinary Biomarkers to Identify the Potential for Aminoglycoside-Induced Nephrotoxicity in Premature Neonates: A Proof-of-Concept Study. PLOS ONE, 7(8). doi:10.1371/journal.pone.0043809

DOI: 10.1371/journal.pone.0043809

Pharmacogenetics of Adverse Drug Reactions (Chapter)

Daly, A. K., Armstrong, M., & Pirmohamed, M. (n.d.). Pharmacogenetics of Adverse Drug Reactions. In Pharmacogenetics and Individualized Therapy (pp. 295-321). John Wiley & Sons, Inc.. doi:10.1002/9781118116494.ch10

DOI: 10.1002/9781118116494.ch10

General pharmacology (Chapter)

Schachter, M., & Pirmohamed, M. (2012). General pharmacology. In Clinical Pharmacology (pp. 74-109). Elsevier. doi:10.1016/b978-0-7020-4084-9.00047-1

DOI: 10.1016/b978-0-7020-4084-9.00047-1

Commentary: changing aetiology of peptic ulcers - author's reply (Journal article)

Musumba, C., Pritchard, D. M., & Pirmohamed, M. (2012). Commentary: changing aetiology of peptic ulcers - author's reply. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(3), 292-293. doi:10.1111/j.1365-2036.2012.05176.x

DOI: 10.1111/j.1365-2036.2012.05176.x

CYP2C19*17 GAIN OF FUNCTION MUTATION IS ASSOCIATED WITH PEPTIC ULCER DISEASE (Journal article)

Musumba, C. O., Eker, D. V., Jorgensen, A., Pritchard, D. M., & Pirmohamed, M. (2012). CYP2C19*17 GAIN OF FUNCTION MUTATION IS ASSOCIATED WITH PEPTIC ULCER DISEASE. GUT, 61, A363. doi:10.1136/gutjnl-2012-302514d.165

DOI: 10.1136/gutjnl-2012-302514d.165

In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers (Journal article)

Alfirevic, A., Gonzalez-Galarza, F., Bell, C., Martinsson, K., Platt, V., Bretland, G., . . . Pirmohamed, M. (2012). In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers. GENOME MEDICINE, 4. doi:10.1186/gm350

DOI: 10.1186/gm350

Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis (Journal article)

El-Ghaiesh, S., Monshi, M. M., Whitaker, P., Jenkins, R., Meng, X., Farrell, J., . . . Naisbitt, D. J. (2012). Characterization of the Antigen Specificity of T-Cell Clones from Piperacillin-Hypersensitive Patients with Cystic Fibrosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 341(3), 597-610. doi:10.1124/jpet.111.190900

DOI: 10.1124/jpet.111.190900

An evaluation of gene-gene interaction between the CYP2C9 and VKORC1 genotypes affecting the anticoagulant effect of phenprocoumon and acenocoumarol (Journal article)

Van Schie, R. M. F., Babajeff, A. M. V., Schalekamp, T., Wessels, J. A. M., Le Cessie, S., De Boer, A., . . . Grp, E. U. -P. A. C. T. S. (2012). An evaluation of gene-gene interaction between the CYP2C9 and VKORC1 genotypes affecting the anticoagulant effect of phenprocoumon and acenocoumarol. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10(5), 767-772. doi:10.1111/j.1538-7836.2012.04694.x

DOI: 10.1111/j.1538-7836.2012.04694.x

CYP2C19*17 Gain of Function Mutation is Associated With the Development of Peptic Ulcer Disease (Conference Paper)

Musumba, C. O., Van Eker, D., Jorgensen, A. L., Zhang, E., O'Hara, N., Pritchard, M., & Pirmohamed, M. (2012). CYP2C19*17 Gain of Function Mutation is Associated With the Development of Peptic Ulcer Disease. In GASTROENTEROLOGY Vol. 142 (pp. S502). Retrieved from http://gateway.webofknowledge.com/

Genetics and the potential for predictive tests in adverse drug reactions. (Journal article)

Pirmohamed, M. (2012). Genetics and the potential for predictive tests in adverse drug reactions.. Chemical immunology and allergy, 97, 18-31. doi:10.1159/000335613

DOI: 10.1159/000335613

Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing (Journal article)

Martin, M. A., Klein, T. E., Dong, B. J., Pirmohamed, M., Haas, D. W., & Kroetz, D. L. (2012). Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing. CLINICAL PHARMACOLOGY & THERAPEUTICS, 91(4), 734-738. doi:10.1038/clpt.2011.355

DOI: 10.1038/clpt.2011.355

Genome-wide association study of serious blistering skin rash caused by drugs (Journal article)

Shen, Y., Nicoletti, P., Floratos, A., Pirmohamed, M., Molokhia, M., Geppetti, P., . . . Events, I. S. A. (2012). Genome-wide association study of serious blistering skin rash caused by drugs. PHARMACOGENOMICS JOURNAL, 12(2), 96-104. doi:10.1038/tpj.2010.84

DOI: 10.1038/tpj.2010.84

Long-term anticoagulant effects of the CYP2C9 and VKORC1 genotypes in acenocoumarol users (Journal article)

Verhoef, T. I., Redekop, W. K., Buikema, M. M., Schalekamp, T., van der Meer, F. J. M., Le Cessie, S., . . . Grp, E. U. -P. A. C. T. (2012). Long-term anticoagulant effects of the CYP2C9 and VKORC1 genotypes in acenocoumarol users. JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 10(4), 606-614. doi:10.1111/j.1538-7836.2012.04633.x

DOI: 10.1111/j.1538-7836.2012.04633.x

Lamotrigine is a substrate for OCT1 in brain endothelial cells (Journal article)

Dickens, D., Owen, A., Alfirevic, A., Giannoudis, A., Davies, A., Weksler, B., . . . Pirmohamed, M. (2012). Lamotrigine is a substrate for OCT1 in brain endothelial cells. BIOCHEMICAL PHARMACOLOGY, 83(6), 805-814. doi:10.1016/j.bcp.2011.12.032

DOI: 10.1016/j.bcp.2011.12.032

EXPLORING THE GENETIC BASIS OF PHARMACORESISTANCE IN EPILEPSY: AN INTEGRATIVE ANALYSIS OF LARGE-SCALE GENE EXPRESSION PROFILING STUDIES ON BRAIN TISSUE FROM EPILEPSY SURGERY (Journal article)

Mirza, N., Vasieva, O., Marson, A. G., & Pirmohamed, M. (2012). EXPLORING THE GENETIC BASIS OF PHARMACORESISTANCE IN EPILEPSY: AN INTEGRATIVE ANALYSIS OF LARGE-SCALE GENE EXPRESSION PROFILING STUDIES ON BRAIN TISSUE FROM EPILEPSY SURGERY. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 83(3). doi:10.1136/jnnp-2011-301993.94

DOI: 10.1136/jnnp-2011-301993.94

Release of intracellular calcium primes chronic myeloid leukaemia cells for tyrosine kinase inhibitor-induced apoptosis (Journal article)

Forchap, S. L., Pirmohamed, M., & Clark, R. E. (2012). Release of intracellular calcium primes chronic myeloid leukaemia cells for tyrosine kinase inhibitor-induced apoptosis. LEUKEMIA, 26(3), 490-498. doi:10.1038/leu.2011.231

DOI: 10.1038/leu.2011.231

Reported paediatric adverse drug reactions in the UK 2000-2009 (Journal article)

Hawcutt, D. B., Mainie, P., Riordan, A., Smyth, R. L., & Pirmohamed, M. (2012). Reported paediatric adverse drug reactions in the UK 2000-2009. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 73(3), 437-446. doi:10.1111/j.1365-2125.2011.04113.x

DOI: 10.1111/j.1365-2125.2011.04113.x

Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy (Journal article)

Horne, B. D., Lenzini, P. A., Wadelius, M., Jorgensen, A. L., Kimmel, S. E., Ridker, P. M., . . . Gage, B. F. (2012). Pharmacogenetic warfarin dose refinements remain significantly influenced by genetic factors after one week of therapy. THROMBOSIS AND HAEMOSTASIS, 107(2), 232-240. doi:10.1160/TH11-06-0388

DOI: 10.1160/TH11-06-0388

Pragmatic randomised trials using routine electronic health records: putting them to the test (Journal article)

van Staa, T. -P., Goldacre, B., Gulliford, M., Cassell, J., Pirmohamed, M., Taweel, A., . . . Smeeth, L. (2012). Pragmatic randomised trials using routine electronic health records: putting them to the test. BMJ-BRITISH MEDICAL JOURNAL, 344. doi:10.1136/bmj.e55

DOI: 10.1136/bmj.e55

Pharmacogenetics of Adverse Drug Reactions (Chapter)

Pushpakom, S. P., & Pirmohamed, M. (n.d.). Pharmacogenetics of Adverse Drug Reactions. In Stephens' Detection and Evaluation of Adverse Drug Reactions (pp. 121-156). John Wiley & Sons, Ltd. doi:10.1002/9780470975053.ch2

DOI: 10.1002/9780470975053.ch2

Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS (Journal article)

Liptrott, N. J., Pushpakom, S., Wyen, C., Fätkenheuer, G., Hoffmann, C., Mauss, S., . . . Owen, A. (2012). Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS. Pharmacogenetics and Genomics, 22(1), 10-19. doi:10.1097/fpc.0b013e32834dd82e

DOI: 10.1097/fpc.0b013e32834dd82e

Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS (Journal article)

Liptrott, N. J., Pushpakom, S., Wyen, C., Faetkenheuer, G., Hoffmann, C., Mauss, S., . . . AIDS, G. C. N. H. I. V. (2012). Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDS. PHARMACOGENETICS AND GENOMICS, 22(1), 10-19. doi:10.1097/FPC.0b013e32834dd82e

DOI: 10.1097/FPC.0b013e32834dd82e

HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury (Journal article)

Monshi, M., Faulkner, L., Gibson, A., Jenkins, R. E., Farrell, J., Earnshaw, C. J., . . . Naisbitt, D. J. (2012). HLA-B*57:01-restricted activation of drug-specific T-cells provides the immunological basis for flucloxacillin-induced liver injury. Hepatology.

Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: systematic review and meta-analysis (Journal article)

Danese, E., Montagnana, M., Johnson, J. A., Rettie, A. E., Zambon, C. F., Lubitz, S. A., . . . Fava, C. (2012). Impact of the CYP4F2 p.V433M polymorphism on coumarin dose requirement: systematic review and meta-analysis. Clin Pharmacol Ther, 92(6), 746-756. doi:10.1038/clpt.2012.184

DOI: 10.1038/clpt.2012.184

Off-label and unlicensed medicine use and adverse drug reactions in children: a narrative review of the literature (Journal article)

Mason, J., Pirmohamed, M., & Nunn, T. (2012). Off-label and unlicensed medicine use and adverse drug reactions in children: a narrative review of the literature. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 68(1), 21-28. doi:10.1007/s00228-011-1097-1

DOI: 10.1007/s00228-011-1097-1

Parents' experiences of adverse drug reations in children: qualitative study (Conference Paper)

Arnott, J., Turner, M. A., Hesselgreave, H., Nunn, A. J., Peak, M., Pirmohamed, M., . . . Young, B. (2012). Parents' experiences of adverse drug reations in children: qualitative study. In PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol. 21 (pp. 112). Retrieved from http://gateway.webofknowledge.com/

Pharmacogenetics for the prescriber (Journal article)

Pirmohamed, M. (2012). Pharmacogenetics for the prescriber. Medicine, 40(7), 362-365. doi:10.1016/j.mpmed.2012.04.005

DOI: 10.1016/j.mpmed.2012.04.005

Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal (Journal article)

Alfirevic, A., McCormack, M., Pirmohamed, M., & Cavalleri, G. L. (2012). Response 2 to pharmacogenetic screening to prevent carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome: a critical appraisal. BRITISH JOURNAL OF DERMATOLOGY, 166(1), 12-14. doi:10.1111/j.1365-2133.2011.10760.x

DOI: 10.1111/j.1365-2133.2011.10760.x

The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors (Journal article)

Lane, S., Al-Zubiedi, S., Hatch, E., Matthews, I., Jorgensen, A. L., Deloukas, P., . . . Pirmohamed, M. (2012). The population pharmacokinetics of R- and S-warfarin: effect of genetic and clinical factors. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 73(1), 66-76. doi:10.1111/j.1365-2125.2011.04051.x

DOI: 10.1111/j.1365-2125.2011.04051.x

The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010 (Journal article)

Musumba, C., Jorgensen, A., Sutton, L., Van Eker, D., Moorcroft, J., Hopkins, M., . . . Pirmohamed, M. (2012). The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 36(1), 48-56. doi:10.1111/j.1365-2036.2012.05118.x

DOI: 10.1111/j.1365-2036.2012.05118.x

2011

Establishment of an HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions (Journal article)

Bell, C., Martinsson, K., Faulkner, L., Alfirevic, A., French, N., Tugwood, J., . . . Park, B. K. (2011). Establishment of an HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions. TOXICOLOGY, 290(2-3), 132-133. doi:10.1016/j.tox.2011.09.057

DOI: 10.1016/j.tox.2011.09.057

Measurement of the urinary biomarker KIM-1 identifies the potential for aminoglycoside-induced nephrotoxicity in premature neonates (Conference Paper)

Antoine, D. J., McWilliam, S., Sabbisetti, V., Turner, M., Smyth, R., Pirmohamed, M., . . . Park, B. K. (2011). Measurement of the urinary biomarker KIM-1 identifies the potential for aminoglycoside-induced nephrotoxicity in premature neonates. In TOXICOLOGY Vol. 290 (pp. 107). doi:10.1016/j.tox.2011.09.015

DOI: 10.1016/j.tox.2011.09.015

Novel OCT1 and OCT2 genetic variations-Potential link to metformin associated vitamin B-12 deficiency during diabetes (Conference Paper)

Green, L. A., Antoine, D. J., Mills, T., Nicholls, G., Park, B. K., & Pirmohamed, M. (2011). Novel OCT1 and OCT2 genetic variations-Potential link to metformin associated vitamin B-12 deficiency during diabetes. In TOXICOLOGY Vol. 290 (pp. 143-144). doi:10.1016/j.tox.2011.09.074

DOI: 10.1016/j.tox.2011.09.074

Development and Inter-Rater Reliability of the Liverpool Adverse Drug Reaction Causality Assessment Tool (Journal article)

Gallagher, R. M., Kirkham, J. J., Mason, J. R., Bird, K. A., Williamson, P. R., Nunn, A. J., . . . Pirmohamed, M. (2011). Development and Inter-Rater Reliability of the Liverpool Adverse Drug Reaction Causality Assessment Tool. PLOS ONE, 6(12). doi:10.1371/journal.pone.0028096

DOI: 10.1371/journal.pone.0028096

DABIGATRAN V WARFARIN Authors' reply to Zermansky and Khatib (Journal article)

Hughes, D. A., Pink, J., Lane, S., & Pirmohamed, M. (2011). DABIGATRAN V WARFARIN Authors' reply to Zermansky and Khatib. BRITISH MEDICAL JOURNAL, 343. doi:10.1136/bmj.d7718

DOI: 10.1136/bmj.d7718

Exploring the genomic basis of pharmacoresistance in epilepsy: an integrative analysis of large-scale gene expression profiling studies on brain tissue from epilepsy surgery (Journal article)

Mirza, N., Vasieva, O., Marson, A. G., & Pirmohamed, M. (2011). Exploring the genomic basis of pharmacoresistance in epilepsy: an integrative analysis of large-scale gene expression profiling studies on brain tissue from epilepsy surgery. HUMAN MOLECULAR GENETICS, 20(22), 4381-4394. doi:10.1093/hmg/ddr365

DOI: 10.1093/hmg/ddr365

A Proposal for an Individualized Pharmacogenetics-Based Warfarin Initiation Dose Regimen for Patients Commencing Anticoagulation Therapy (Journal article)

Avery, P. J., Jorgensen, A., Hamberg, A., Wadelius, M., Pirmohamed, M., Kamali, F., & Grp, E. U. -P. A. C. T. S. (2011). A Proposal for an Individualized Pharmacogenetics-Based Warfarin Initiation Dose Regimen for Patients Commencing Anticoagulation Therapy. CLINICAL PHARMACOLOGY & THERAPEUTICS, 90(5), 701-706. doi:10.1038/clpt.2011.186

DOI: 10.1038/clpt.2011.186

Pharmacogenomics in neurology: Current state and future steps (Journal article)

Chan, A., Pirmohamed, M., & Comabella, M. (2011). Pharmacogenomics in neurology: Current state and future steps. ANNALS OF NEUROLOGY, 70(5), 684-697. doi:10.1002/ana.22502

DOI: 10.1002/ana.22502

URINARY KIM-1 AS A BIOMARKER OF AMINOGLYCOSIDE-INDUCED NEPHROTOXICITY IN PREMATURE NEONATES (Conference Paper)

McWilliam, S. J., Antoine, D. J., Turner, M., Sabbisetti, V., Bonventre, J. V., Park, B. K., . . . Pirmohamed, M. (2011). URINARY KIM-1 AS A BIOMARKER OF AMINOGLYCOSIDE-INDUCED NEPHROTOXICITY IN PREMATURE NEONATES. In PEDIATRIC RESEARCH Vol. 70 (pp. 107). doi:10.1038/pr.2011.332

DOI: 10.1038/pr.2011.332

Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses (Journal article)

Pink, J., Lane, S., Pirmohamed, M., & Hughes, D. A. (2011). Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses. BMJ-BRITISH MEDICAL JOURNAL, 343. doi:10.1136/bmj.d6333

DOI: 10.1136/bmj.d6333

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 Genotypes and Warfarin Dosing (Journal article)

Johnson, J. A., Gong, L., Whirl-Carrillo, M., Gage, B. F., Scott, S. A., Stein, C. M., . . . Altman, R. B. (2011). Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 Genotypes and Warfarin Dosing. CLINICAL PHARMACOLOGY & THERAPEUTICS, 90(4), 625-629. doi:10.1038/clpt.2011.185

DOI: 10.1038/clpt.2011.185

Pharmacogenetics: past, present and future (Journal article)

Pirmohamed, M. (2011). Pharmacogenetics: past, present and future. DRUG DISCOVERY TODAY, 16(19-20), 852-861. doi:10.1016/j.drudis.2011.08.006

DOI: 10.1016/j.drudis.2011.08.006

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)

Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871

DOI: 10.1124/jpet.111.183871

Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients (Journal article)

Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338(3), 841-849. doi:10.1124/jpet.111.183871

DOI: 10.1124/jpet.111.183871

Characterisation and Carriage Ratio of Clostridium difficile Strains Isolated from a Community-Dwelling Elderly Population in the United Kingdom (Journal article)

Miyajima, F., Roberts, P., Swale, A., Price, V., Jones, M., Horan, M., . . . Pirmohamed, M. (2011). Characterisation and Carriage Ratio of Clostridium difficile Strains Isolated from a Community-Dwelling Elderly Population in the United Kingdom. PLOS ONE, 6(8). doi:10.1371/journal.pone.0022804

DOI: 10.1371/journal.pone.0022804

Early Deaths During Tuberculosis Treatment Are Associated With Depressed Innate Responses, Bacterial Infection, and Tuberculosis Progression (Journal article)

Waitt, C. J., Banda, N. P. K., White, S. A., Kampmann, B., Kumwenda, J., Heyderman, R. S., . . . Squire, S. B. (2011). Early Deaths During Tuberculosis Treatment Are Associated With Depressed Innate Responses, Bacterial Infection, and Tuberculosis Progression. JOURNAL OF INFECTIOUS DISEASES, 204(3), 358-362. doi:10.1093/infdis/jir265

DOI: 10.1093/infdis/jir265

INFLUENCE OF A FUNCTIONAL SCN1A POLYMORPHISM ON MAXIMUM AND MAINTENANCE DOSES OF ANTIEPILEPTIC DRUGS IN NEWLY DIAGNOSED EPILEPSY (Conference Paper)

Shazadi, K., Sills, G. J., Pirmohamed, M., & Marson, A. G. (2011). INFLUENCE OF A FUNCTIONAL SCN1A POLYMORPHISM ON MAXIMUM AND MAINTENANCE DOSES OF ANTIEPILEPTIC DRUGS IN NEWLY DIAGNOSED EPILEPSY. In EPILEPSIA Vol. 52 (pp. 91-92). Retrieved from http://gateway.webofknowledge.com/

Loading and maintenance dose algorithms for phenprocoumon and acenocoumarol using patient characteristics and pharmacogenetic data (Journal article)

van Schie, R. M. F., Wessels, J. A. M., le Cessie, S., de Boer, A., Schalekamp, T., van der Meer, F. J. M., . . . Grp, E. U. -P. A. C. T. S. (2011). Loading and maintenance dose algorithms for phenprocoumon and acenocoumarol using patient characteristics and pharmacogenetic data. EUROPEAN HEART JOURNAL, 32(15), 1909-1917. doi:10.1093/eurheartj/ehr116

DOI: 10.1093/eurheartj/ehr116

STAtin-Induced Muscle Toxicity: Exploration Using the UK GEneral Practice Research Database - Recruitment (Conference Paper)

Campbell, J., van Staa, T. P., McCann, G., O'Meara, H., & Pirmohamed, M. (2011). STAtin-Induced Muscle Toxicity: Exploration Using the UK GEneral Practice Research Database - Recruitment. In PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol. 20 (pp. S183). Retrieved from http://gateway.webofknowledge.com/

VALIDATION OF THE AUSTRALIAN FIVE-SNP GENETIC CLASSIFIER OF EARLY TREATMENT OUTCOMES IN NEWLY DIAGNOSED EPILEPSY (Conference Paper)

Sills, G., Shazadi, K., Petrovski, S., O'Brien, T., Pirmohamed, M., & Marson, A. (2011). VALIDATION OF THE AUSTRALIAN FIVE-SNP GENETIC CLASSIFIER OF EARLY TREATMENT OUTCOMES IN NEWLY DIAGNOSED EPILEPSY. In EPILEPSIA Vol. 52 (pp. 92). Retrieved from http://gateway.webofknowledge.com/

A randomised controlled trial of extended brief intervention for alcohol dependent patients in an acute hospital setting (ADPAC) (Journal article)

Owens, L., Butcher, G., Gilmore, I., Kolamunnage-Dona, R., Oyee, J., Perkins, L., . . . Pirmohamed, M. (2011). A randomised controlled trial of extended brief intervention for alcohol dependent patients in an acute hospital setting (ADPAC). BMC PUBLIC HEALTH, 11. doi:10.1186/1471-2458-11-528

DOI: 10.1186/1471-2458-11-528

Brief Interventions in Dependent Drinkers: A Comparative Prospective Analysis in Two Hospitals (Journal article)

Cobain, K., Owens, L., Kolamunnage-Dona, R., Fitzgerald, R., Gilmore, I., & Pirmohamed, M. (2011). Brief Interventions in Dependent Drinkers: A Comparative Prospective Analysis in Two Hospitals. ALCOHOL AND ALCOHOLISM, 46(4), 434-440. doi:10.1093/alcalc/agr044

DOI: 10.1093/alcalc/agr044

Genetic Variants of ABCC10, a Novel Tenofovir Transporter, Are Associated With Kidney Tubular Dysfunction (Journal article)

Pushpakom, S. P., Liptrott, N. J., Rodríguez-Nóvoa, S., Labarga, P., Soriano, V., Albalater, M., . . . Owen, A. (2011). Genetic Variants of ABCC10, a Novel Tenofovir Transporter, Are Associated With Kidney Tubular Dysfunction. The Journal of Infectious Diseases, 204(1), 145-153. doi:10.1093/infdis/jir215

DOI: 10.1093/infdis/jir215

Genetic Variants of ABCC10, a Novel Tenofovir Transporter, Are Associated With Kidney Tubular Dysfunction (Journal article)

Pushpakom, S. P., Liptrott, N. J., Rodriguez-Novoa, S., Labarga, P., Soriano, V., Albalater, M., . . . Owen, A. (2011). Genetic Variants of ABCC10, a Novel Tenofovir Transporter, Are Associated With Kidney Tubular Dysfunction. JOURNAL OF INFECTIOUS DISEASES, 204(1), 145-153. doi:10.1093/infdis/jir215

DOI: 10.1093/infdis/jir215

Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis (Journal article)

Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass Spectrometric Characterization of Circulating and Functional Antigens Derived from Piperacillin in Patients with Cystic Fibrosis. JOURNAL OF IMMUNOLOGY, 187(1), 200-211. doi:10.4049/jimmunol.1100647

DOI: 10.4049/jimmunol.1100647

Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways (Journal article)

El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. -K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Trimethoprim Stimulates T-Cells through Metabolism-Dependent and -Independent Pathways. CHEMICAL RESEARCH IN TOXICOLOGY, 24(6), 791-793. doi:10.1021/tx2001256

DOI: 10.1021/tx2001256

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines? (Journal article)

Laverty, H. G., Benson, C., Cartwright, E. J., Cross, M. J., Garland, C., Hammond, T., . . . Valentin, J. P. (2011). How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?. BRITISH JOURNAL OF PHARMACOLOGY, 163(4), 675-693. doi:10.1111/j.1476-5381.2011.01255.x

DOI: 10.1111/j.1476-5381.2011.01255.x

Phenotype Standardization for Immune-Mediated Drug-Induced Skin Injury (Journal article)

Pirmohamed, M., Friedmann, P. S., Molokhia, M., Loke, Y. K., Smith, C., Phillips, E., . . . Shear, N. H. (2011). Phenotype Standardization for Immune-Mediated Drug-Induced Skin Injury. CLINICAL PHARMACOLOGY & THERAPEUTICS, 89(6), 896-901. doi:10.1038/clpt.2011.79

DOI: 10.1038/clpt.2011.79

The Phenotype Standardization Project: Improving Pharmacogenetic Studies of Serious Adverse Drug Reactions (Journal article)

Pirmohamed, M., Aithal, G. P., Behr, E., Daly, A., & Roden, D. (2011). The Phenotype Standardization Project: Improving Pharmacogenetic Studies of Serious Adverse Drug Reactions. CLINICAL PHARMACOLOGY & THERAPEUTICS, 89(6), 784-785. doi:10.1038/clpt.2011.30

DOI: 10.1038/clpt.2011.30

The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein (Journal article)

Vogler, M., Dickens, D., Dyer, M. J. S., Owen, A., Pirmohamed, M., & Cohen, G. M. (2011). The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 408(2), 344-349. doi:10.1016/j.bbrc.2011.04.043

DOI: 10.1016/j.bbrc.2011.04.043

Aspirin resistance: Effect of clinical, biochemical and genetic factors (Journal article)

FitzGerald, R., & Pirmohamed, M. (2011). Aspirin resistance: Effect of clinical, biochemical and genetic factors. PHARMACOLOGY & THERAPEUTICS, 130(2), 213-225. doi:10.1016/j.pharmthera.2011.01.011

DOI: 10.1016/j.pharmthera.2011.01.011

Changing Trends in Peptic Ulcer Disease: The Rise of NSAID-Induced and Fall of Helicobacter pylori-Induced Ulcers (Conference Paper)

Musumba, C. O., Van Eker, D., Jorgensen, A., Pritchard, M., & Pirmoltamed, M. (2011). Changing Trends in Peptic Ulcer Disease: The Rise of NSAID-Induced and Fall of Helicobacter pylori-Induced Ulcers. In GASTROENTEROLOGY Vol. 140 (pp. S176). Retrieved from http://gateway.webofknowledge.com/

Hypersensitivity reactions to HIV therapy (Journal article)

Chaponda, M., & Pirmohamed, M. (2011). Hypersensitivity reactions to HIV therapy. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 71(5), 659-671. doi:10.1111/j.1365-2125.2010.03784.x

DOI: 10.1111/j.1365-2125.2010.03784.x

Metabolic acidosis with topiramate and zonisamide (Journal article)

Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2011). Metabolic acidosis with topiramate and zonisamide. Pharmacogenetics and Genomics, 21(5), 297-302. doi:10.1097/fpc.0b013e3283441b95

DOI: 10.1097/fpc.0b013e3283441b95

Adverse drug reactions causing admission to a paediatric hospital: a pilot study (Journal article)

Gallagher, R. M., Bird, K. A., Mason, J. R., Peak, M., Williamson, P. R., Nunn, A. J., . . . Smyth, R. L. (2011). Adverse drug reactions causing admission to a paediatric hospital: a pilot study. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 36(2), 194-199. doi:10.1111/j.1365-2710.2010.01194.x

DOI: 10.1111/j.1365-2710.2010.01194.x

Adverse drug reactions causing admission to a paediatric hospital: a pilot study (Journal article)

Gallagher, R. M., Bird, K. A., Mason, J. R., Peak, M., Williamson, P. R., Nunn, A. J., . . . Smyth, R. L. (2011). Adverse drug reactions causing admission to a paediatric hospital: a pilot study. Journal of Clinical Pharmacy and Therapeutics, 36(2), 194-199. doi:10.1111/j.1365-2710.2010.01194.x

DOI: 10.1111/j.1365-2710.2010.01194.x

CHANGING TRENDS IN PEPTIC ULCER DISEASE: THE RISE OF NSAID-INDUCED AND FALL OF H PYLORI-INDUCED ULCERS (Conference Paper)

Musumba, C. O., Van Eker, D., Jorgensen, A., Pritchard, M., & Pirmohamed, M. (2011). CHANGING TRENDS IN PEPTIC ULCER DISEASE: THE RISE OF NSAID-INDUCED AND FALL OF H PYLORI-INDUCED ULCERS. In GUT Vol. 60. doi:10.1136/gut.2011.239301.219

DOI: 10.1136/gut.2011.239301.219

HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans (Journal article)

McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J. J., Kasperaviciute, D., Carrington, M., . . . Pirmohamed, M. (2011). HLA-A*3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans. NEW ENGLAND JOURNAL OF MEDICINE, 364(12), 1134-1143. doi:10.1056/NEJMoa1013297

DOI: 10.1056/NEJMoa1013297

Risk modeling strategies for pharmacogenetic studies (Journal article)

Jorgensen, A. L., & Pirmohamed, M. (2011). Risk modeling strategies for pharmacogenetic studies. PHARMACOGENOMICS, 12(3), 397-410. doi:10.2217/PGS.10.198

DOI: 10.2217/PGS.10.198

A randomised controlled trial of extended brief intervention for alcohol dependent patients in an acute hospital setting (ADPAC) (Journal article)

Adipogenic gene variants in patients with HIV-associated lipodystrophy (Journal article)

Pushpakom, S. P., Owen, A., Vilar, F. J., Castro, H., Dunn, D. T., Back, D. J., & Pirmohamed, M. (2011). Adipogenic gene variants in patients with HIV-associated lipodystrophy. PHARMACOGENETICS AND GENOMICS, 21(2), 76-83. doi:10.1097/FPC.0b013e328342a917

DOI: 10.1097/FPC.0b013e328342a917

An Investigation of Disagreement in Causality Assessment of Adverse Drug Reactions (Journal article)

Davies, E. C., Rowe, P. H., James, S., Nickless, G., Ganguli, A., Danjuma, M., . . . Pirmohamed, M. (2011). An Investigation of Disagreement in Causality Assessment of Adverse Drug Reactions. Pharmaceutical Medicine, 25(1), 17-24. doi:10.1007/bf03256843

DOI: 10.1007/bf03256843

Brief interventions in dependent drinkers: A comparative prospective analysis in two hospitals (Journal article)

Cobain, K., Owens, L., Fitzgerald, R., Gilmore, I., & Pirmohamed, M. (2011). Brief interventions in dependent drinkers: A comparative prospective analysis in two hospitals. Alcohol & Alcoholism, 46(6), 434-440.

Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology (Journal article)

Eschenhagen, T., Force, T., Ewer, M. S., de Keulenaer, G. W., Suter, T. M., Anker, S. D., . . . Shah, A. M. (2011). Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology. EUROPEAN JOURNAL OF HEART FAILURE, 13(1), 1-10. doi:10.1093/eurjhf/hfq213

DOI: 10.1093/eurjhf/hfq213

Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury (Journal article)

El-Ghaiesh, S., Sanderson, J. P., Farrell, J., Lavergne, S. N., Syn, W. -K., Pirmohamed, M., . . . Naisbitt, D. J. (2011). Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 128(3), 680-U368. doi:10.1016/j.jaci.2011.04.031

DOI: 10.1016/j.jaci.2011.04.031

Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: systematic review and meta-analyses (Journal article)

Fleeman, N., Dundar, Y., Dickson, R., Jorgensen, A., Pushpakom, S., McLeod, C., . . . Walley, T. (2011). Cytochrome P450 testing for prescribing antipsychotics in adults with schizophrenia: systematic review and meta-analyses. PHARMACOGENOMICS JOURNAL, 11(1), 1-14. doi:10.1038/tpj.2010.73

DOI: 10.1038/tpj.2010.73

Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis (Journal article)

Whitaker, P., Meng, X., Lavergne, S. N., El-Ghaiesh, S., Monshi, M., Earnshaw, C., . . . Park, B. K. (2011). Mass spectrometric characterization of circulating and functional antigens derived from piperacillin in patients with cystic fibrosis. J Immunol, 187(1), 200-211. doi:10.4049/jimmunol.1100647

DOI: 10.4049/jimmunol.1100647

Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors (Journal article)

Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2011). Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. PHARMACOGENETICS AND GENOMICS, 21(5), 297-302. doi:10.1097/FPC.0b013e3283441b95

DOI: 10.1097/FPC.0b013e3283441b95

Pharmacogenetics of adverse drug reactions (Chapter)

Pushpakom, S., & Pirmohamed, M. (2011). Pharmacogenetics of adverse drug reactions. In J. Talbott, & P. Waller (Eds.), Stephens' Detection of New Adverse Drug Reactions (pp. Not known). Malden, MA, USA: John Wiley & Sons.

Prescribing in liver disease (Journal article)

Pirmohamed, M. (2011). Prescribing in liver disease. Medicine, 39(9), 541-544. doi:10.1016/j.mpmed.2011.06.009

DOI: 10.1016/j.mpmed.2011.06.009

Randomised Evaluations of Accepted Choices in Treatment (REACT) trials: large-scale pragmatic trials within databases of routinely collected electronic healthcare records (Journal article)

van Staa, T. -P., Goldacre, B., Gulliford, M., Cassell, J., Pirmohamed, M., Taweel, A., . . . Smeeth, L. (2011). Randomised Evaluations of Accepted Choices in Treatment (REACT) trials: large-scale pragmatic trials within databases of routinely collected electronic healthcare records. Trials, 12(Suppl 1), A104.

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles (Journal article)

Lucena, M. I., Molokhia, M., Shen, Y., Urban, T. J., Aithal, G. P., Andrade, R. J., . . . SAEC, I. (2011). Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles. GASTROENTEROLOGY, 141(1), 338-347. doi:10.1053/j.gastro.2011.04.001

DOI: 10.1053/j.gastro.2011.04.001

2010

Drug Induced Hypersensitivity and the HLA Complex (Journal article)

Alfirevic, A., & Pirmohamed, M. (2010). Drug Induced Hypersensitivity and the HLA Complex. Pharmaceuticals (Basel, Switzerland), 4(1), 69-90.

Acceptance of Biomarker-Based Tests for Application in Clinical Practice: Criteria and Obstacles (Journal article)

Pirmohamed, M. (2010). Acceptance of Biomarker-Based Tests for Application in Clinical Practice: Criteria and Obstacles. CLINICAL PHARMACOLOGY & THERAPEUTICS, 88(6), 862-866. doi:10.1038/clpt.2010.245

DOI: 10.1038/clpt.2010.245

Characterization of piperacillin-specific T-cell clones from hypersensitive patients with cystic fibrosis (Conference Paper)

El-Ghaiesh, S., Monshi, M., Jenkins, R., Meng, X., French, N., Whitaker, P., . . . Naisbitt, D. (2010). Characterization of piperacillin-specific T-cell clones from hypersensitive patients with cystic fibrosis. In IMMUNOLOGY Vol. 131 (pp. 117). Retrieved from http://gateway.webofknowledge.com/

Establishment of a HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions (Conference Paper)

Bell, C., Martinsson, K., Faulkner, L., Alfirevic, A., French, N., Tugwood, J., . . . Park, B. K. (2010). Establishment of a HLA-typed cohort to elucidate the cellular and chemical basis of drug hypersensitivity reactions. In IMMUNOLOGY Vol. 131 (pp. 125). Retrieved from http://gateway.webofknowledge.com/

Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury (Journal article)

Donaldson, P. T., Daly, A. K., Henderson, J., Graham, J., Pirmohamed, M., Bernal, W., . . . Aithal, G. P. (2010). Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury. JOURNAL OF HEPATOLOGY, 53(6), 1049-1053. doi:10.1016/j.jhep.2010.05.033

DOI: 10.1016/j.jhep.2010.05.033

Involvement of drug-specific CD4(+) and CD8(+) T-cells in trimethoprim-mediated hepatitis (Conference Paper)

El-Ghaiesh, S., Lavergne, S., Farrell, J., Syn, W., Pirmohamed, M., Park, K., & Naisbitt, D. (2010). Involvement of drug-specific CD4(+) and CD8(+) T-cells in trimethoprim-mediated hepatitis. In IMMUNOLOGY Vol. 131 (pp. 120). Retrieved from http://gateway.webofknowledge.com/

Population pharmacokinetic and pharmacogenetic analysis of nevirapine in hypersensitive and tolerant HIV-infected patients from Malawi (Conference Paper)

Dickinson, L., Chaponda, M., Carr, D., van Oosterhout, J. J., Kumwenda, J., Lalloo, D. G., . . . Khoo, S. H. (2010). Population pharmacokinetic and pharmacogenetic analysis of nevirapine in hypersensitive and tolerant HIV-infected patients from Malawi. In Abstracts of the Tenth International Congress on Drug Therapy in HIV Infection Vol. 13 (pp. 181). Glasgow, UK: Journal of the International AIDS Society. doi:10.1186/1758-2652-13-S4-P181

DOI: 10.1186/1758-2652-13-S4-P181

Emergency re-admissions to hospital due to adverse drug reactions within 1 year of the index admission (Journal article)

Davies, E. C., Green, C. F., Mottram, D. R., Rowe, P. H., & Pirmohamed, M. (2010). Emergency re-admissions to hospital due to adverse drug reactions within 1 year of the index admission. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 70(5), 749-755. doi:10.1111/j.1365-2125.2010.03751.x

DOI: 10.1111/j.1365-2125.2010.03751.x

P13.04 Exploring the clinical utility of faecal biomarkers to investigate Clostridium difficile infection (CDI) (Journal article)

Swale, A., Miyajima, F., Farragher, T., Roberts, P., Little, M., Beeching, N. J., . . . Pirmohamed, M. (2010). P13.04 Exploring the clinical utility of faecal biomarkers to investigate Clostridium difficile infection (CDI). Journal of Hospital Infection, 76, S42. doi:10.1016/s0195-6701(10)60141-7

DOI: 10.1016/s0195-6701(10)60141-7

Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort (Journal article)

Carr, D. F., la Porte, C. J. L., Pirmohamed, M., Owen, A., & Cortes, C. P. (2010). Haplotype structure of CYP2B6 and association with plasma efavirenz concentrations in a Chilean HIV cohort. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 65(9), 1889-1893. doi:10.1093/jac/dkq260

DOI: 10.1093/jac/dkq260

CYP4F2 genotype-phenotype correlation in human liver (Conference Paper)

Zhang, J. E., Jorgensen, A., Kline, K., Alfirevic, A., Zanger, U., & Pirmohamed, M. (2010). CYP4F2 genotype-phenotype correlation in human liver. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 297-298). Retrieved from http://gateway.webofknowledge.com/

Carbamazepine-induced hypersensitivity in Caucasians and genetic variability in the major histocompatibility complex (Conference Paper)

Alfirevic, A., Bourgeois, S., Jorgensen, A., Steen, K., Weetman, D., Park, B. K., . . . Pirmohamed, M. (2010). Carbamazepine-induced hypersensitivity in Caucasians and genetic variability in the major histocompatibility complex. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 298). Retrieved from http://gateway.webofknowledge.com/

Genetic Risk Factors for ADRs (Conference Paper)

Pirmohamed, M. (2010). Genetic Risk Factors for ADRs. In DRUG METABOLISM REVIEWS Vol. 42 (pp. 2-3). Retrieved from http://gateway.webofknowledge.com/

Proposal of a pharmacogenetic-based dosing algorithm for the induction of warfarin anticoagulation therapy in patients with thromboembolic disease (Conference Paper)

Avery, P., Pirmohamed, M., Jorgensen, A., & Kamali, F. (2010). Proposal of a pharmacogenetic-based dosing algorithm for the induction of warfarin anticoagulation therapy in patients with thromboembolic disease. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 291). Retrieved from http://gateway.webofknowledge.com/

Recruitment Strategy for Genetic Data Collection: The UK General Practice Research Database (Conference Paper)

Setakis, E., de Vries, F., Pirmohamed, M., & van Staa, T. -P. (2010). Recruitment Strategy for Genetic Data Collection: The UK General Practice Research Database. In PHARMACOEPIDEMIOLOGY AND DRUG SAFETY Vol. 19 (pp. S37). Retrieved from http://gateway.webofknowledge.com/

VKORC1 and warfarin resistance (Conference Paper)

Zhang, J. E., Alfirevic, A., Carr, D., Spencer, K., Mountford, R., & Pirmohamed, M. (2010). VKORC1 and warfarin resistance. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 70 (pp. 297). Retrieved from http://gateway.webofknowledge.com/

A mechanistic investigation of the predisposing factors for idiosyncratic drug reactions. (Journal article)

Pirmohamed, M. (2010). A mechanistic investigation of the predisposing factors for idiosyncratic drug reactions..

A systematic review of cost effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives (Journal article)

Verhoef, T. I., Redekop, W. K., Darba, J., Geitona, M., Hughes, D. A., Siebert, U., . . . Grp, E. U. -P. A. C. T. (2010). A systematic review of cost effectiveness analyses of pharmacogenetic-guided dosing in treatment with coumarin derivatives. PHARMACOGENOMICS, 11(7), 989-1002. doi:10.2217/PGS.10.74

DOI: 10.2217/PGS.10.74

Interpreting adverse drug reaction (ADR) reports as hospital patient safety incidents (Journal article)

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2010). Interpreting adverse drug reaction (ADR) reports as hospital patient safety incidents. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 70(1), 102-108. doi:10.1111/j.1365-2125.2010.03671.x

DOI: 10.1111/j.1365-2125.2010.03671.x

Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (vol 38, pg 122, 2010) (Journal article)

Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (vol 38, pg 122, 2010). DRUG METABOLISM AND DISPOSITION, 38(7), 1259. doi:10.1124/dmd.38.7.1259

DOI: 10.1124/dmd.38.7.1259

CORRELATION OF HOCT1 M420DEL SNP WITH THE CLINICAL OUTCOME OF CHRONIC MYELOID LEUKAEMIA PATIENTS TREATED WITH IMATINIB (Journal article)

Giannoudis, A., Wang, L., Xynarianos, G., Liloglou, T., Austin, G., Clark, J., . . . Clark, R. (2010). CORRELATION OF HOCT1 M420DEL SNP WITH THE CLINICAL OUTCOME OF CHRONIC MYELOID LEUKAEMIA PATIENTS TREATED WITH IMATINIB. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 95, 341. Retrieved from http://gateway.webofknowledge.com/

GENETIC VARIABILITY IN DRUG METABOLISING ENZYMES AS DETERMINANT OF CARBAMAZEPINE DOSE REQUIREMENT IN NEWLY DIAGNOSED EPILEPSY (Conference Paper)

Shazadi, K., Sills, G. J., Alfirevic, A., Pirmohamed, M., & Marson, A. G. (2010). GENETIC VARIABILITY IN DRUG METABOLISING ENZYMES AS DETERMINANT OF CARBAMAZEPINE DOSE REQUIREMENT IN NEWLY DIAGNOSED EPILEPSY. In EPILEPSIA Vol. 51 (pp. 32). Retrieved from http://gateway.webofknowledge.com/

HOCT1 M420 DELETED TRANSCRIPT LEVELS PREDICT POOR CLINICAL OUTCOME FOR IMATINIB TREATED CML PATIENTS (Journal article)

Wang, L., Giannoudis, A., Austin, G., Liloglou, T., Xinarianos, G., Clark, J., . . . Clark, R. (2010). HOCT1 M420 DELETED TRANSCRIPT LEVELS PREDICT POOR CLINICAL OUTCOME FOR IMATINIB TREATED CML PATIENTS. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 95, 61. Retrieved from http://gateway.webofknowledge.com/

Simultaneous determination of nilotinib, imatinib and its main metabolite (CGP-74588) in human plasma by ultra-violet high performance liquid chromatography (Journal article)

Davies, A., Hayes, A. K., Knight, K., Watmough, S. J., Pirmohamed, M., & Clark, R. E. (2010). Simultaneous determination of nilotinib, imatinib and its main metabolite (CGP-74588) in human plasma by ultra-violet high performance liquid chromatography. LEUKEMIA RESEARCH, 34(6), 702-707. doi:10.1016/j.leukres.2009.11.009

DOI: 10.1016/j.leukres.2009.11.009

Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups (Journal article)

Limdi, N. A., Wadelius, M., Cavallari, L., Eriksson, N., Crawford, D. C., Lee, M. -T. M., . . . Cons, I. W. P. (2010). Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups. BLOOD, 115(18), 3827-3834. doi:10.1182/blood-2009-12-255992

DOI: 10.1182/blood-2009-12-255992

A Role for the Pregnane X Receptor in Flucloxacillin-Induced Liver Injury (Journal article)

Andrews, E., Armstrong, M., Tugwood, J., Swan, D., Glaves, P., Pirmohamed, M., . . . Daly, A. K. (2010). A Role for the Pregnane X Receptor in Flucloxacillin-Induced Liver Injury. HEPATOLOGY, 51(5), 1656-1664. doi:10.1002/hep.23549

DOI: 10.1002/hep.23549

Integration of Genetic, Clinical, and INR Data to Refine Warfarin Dosing (Journal article)

Lenzini, P., Wadelius, M., Kimmel, S., Anderson, J. L., Jorgensen, A. L., Pirmohamed, M., . . . Gage, B. F. (2010). Integration of Genetic, Clinical, and INR Data to Refine Warfarin Dosing. CLINICAL PHARMACOLOGY & THERAPEUTICS, 87(5), 572-578. doi:10.1038/clpt.2010.13

DOI: 10.1038/clpt.2010.13

Altered plasma levels of nevirapine after commencing rifampicin-containing TB regimens in Malawi (Conference Paper)

Chaponda, M., Nyirenda, W., Watson, V., White, S., Van Oosterhout, J., Lalloo, D., . . . Khoo, S. (2010). Altered plasma levels of nevirapine after commencing rifampicin-containing TB regimens in Malawi. In HIV MEDICINE Vol. 11 (pp. 6). Retrieved from http://gateway.webofknowledge.com/

Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future (Journal article)

Alfirevic, A., & Pirmohamed, M. (2010). Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future. PHARMACOGENOMICS, 11(4), 497-499. doi:10.2217/PGS.10.12

DOI: 10.2217/PGS.10.12

Pharmacogenomics: the importance of accurate phenotypes (Journal article)

Gurwitz, D., & Pirmohamed, M. (2010). Pharmacogenomics: the importance of accurate phenotypes. PHARMACOGENOMICS, 11(4), 469-470. doi:10.2217/PGS.10.41

DOI: 10.2217/PGS.10.41

Characterization of p-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein (Journal article)

Jenkinson, C., Jenkins, R. E., Aleksic, M., Pirmohamed, M., Naisbitt, D. J., & Park, B. K. (2010). Characterization of p-Phenylenediamine-Albumin Binding Sites and T-Cell Responses to Hapten-Modified Protein. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(3), 732-742. doi:10.1038/jid.2009.271

DOI: 10.1038/jid.2009.271

Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients (Journal article)

Adetunji, O. R., Blair, J. C., Javadpour, M., Alfirevic, A., Pirmohamed, M., & MacFarlane, I. A. (2010). Deletion of exon 3 in the growth hormone receptor gene in adults with growth hormone deficiency: comparison of symptomatic and asymptomatic patients. CLINICAL ENDOCRINOLOGY, 72(3), 422-423. doi:10.1111/j.1365-2265.2009.03638.x

DOI: 10.1111/j.1365-2265.2009.03638.x

Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells (Journal article)

Antoine, D. J., Srivastava, A., Pirmohamed, M., & Park, B. K. (2010). Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells. BIOCHEMICAL PHARMACOLOGY, 79(4), 647-654. doi:10.1016/j.bcp.2009.09.021

DOI: 10.1016/j.bcp.2009.09.021

Drug-drug interactions and adverse drug reactions: separating the wheat from the chaff (Journal article)

Pirmohamed, M. (2010). Drug-drug interactions and adverse drug reactions: separating the wheat from the chaff. WIENER KLINISCHE WOCHENSCHRIFT, 122(3-4), 62-64. doi:10.1007/s00508-010-1309-1

DOI: 10.1007/s00508-010-1309-1

Pharmacogenetics of idiosyncratic adverse drug reactions. (Journal article)

Pirmohamed, M. (2010). Pharmacogenetics of idiosyncratic adverse drug reactions.. Handbook of experimental pharmacology, (196), 477-491. doi:10.1007/978-3-642-00663-0_17

DOI: 10.1007/978-3-642-00663-0_17

Randomized Controlled Trial: Lisinopril Reduces Proteinuria, Ammonia, and Renal Polypeptide Tubular Catabolism in Patients With Chronic Allograft Nephropathy (Journal article)

Amara, A. B., Sharma, A., Alexander, J. L., Alfirevic, A., Mohiuddin, A., Pirmohamed, M., . . . Rustom, R. (2010). Randomized Controlled Trial: Lisinopril Reduces Proteinuria, Ammonia, and Renal Polypeptide Tubular Catabolism in Patients With Chronic Allograft Nephropathy. TRANSPLANTATION, 89(1), 104-114. doi:10.1097/TP.0b013e3181bf13d9

DOI: 10.1097/TP.0b013e3181bf13d9

Pharmacogenetics in reproductive and perinatal medicine (Journal article)

Alfirevic, A., Alfirevic, Z., & Pirmohamed, M. (2010). Pharmacogenetics in reproductive and perinatal medicine. PHARMACOGENOMICS, 11(1), 65-79. doi:10.2217/PGS.09.153

DOI: 10.2217/PGS.09.153

Drug allergy in lung disease (Chapter)

Ganguli, A., & Pirmohamed, M. (2010). Drug allergy in lung disease. In Drug-Induced and Iatrogenic Respiratory Disease (pp. 52-61).

Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future. (Journal article)

Alfirevic, A., & Pirmohamed, M. (2010). Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future.. Pharmacogenomics, 11(4), 497-499.

Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals (Journal article)

Coulter, E. M., Jenkinson, C., Farrell, J., Lavergne, S. N., Pease, C., White, A., . . . Naisbitt, D. J. (2010). Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130(1), 161-174. doi:10.1038/jid.2009.187

DOI: 10.1038/jid.2009.187

Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals (Journal article)

Coulter, E. M., Jenkinson, C., Farrell, J., Lavergne, S. N., Pease, C., White, A., . . . Naisbitt, D. J. (2010). Measurement of CD4+ and CD8+ T-Lymphocyte Cytokine Secretion and Gene Expression Changes in p-Phenylenediamine Allergic Patients and Tolerant Individuals. Journal of Investigative Dermatology, 130(1), 161-174. doi:10.1038/jid.2009.187

DOI: 10.1038/jid.2009.187

Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors. (Journal article)

Mirza, N. S., Alfirevic, A., Jorgensen, A., Marson, A. G., & Pirmohamed, M. (2010). Metabolic acidosis with topiramate and zonisamide: an assessment of its severity and predictors.. Pharmacogenetics and Genomics, 21(5), 297-302.

Pharmaceuticals - Special Issue on Personalised Medicine (Book)

Sills, G., & Pirmohamed, M. (Eds.) (2010). Pharmaceuticals - Special Issue on Personalised Medicine. Basel: MDPI. Retrieved from http://www.mdpi.com/journal/pharmaceuticals/sections/

Pharmacogenetics in reproductive and perinatal medicine (Journal article)

Alfirevic, A., Alfirevic, Z., & Pirmohamed, M. (2010). Pharmacogenetics in reproductive and perinatal medicine. Pharmacogenomics, 11(1), 65-79.

Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries (Journal article)

Srivastava, A., Lian, L. -Y., Maggs, J. L., Chaponda, M., Pirmohamed, M., Williams, D. P., & Park, B. K. (2010). Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries. DRUG METABOLISM AND DISPOSITION, 38(1), 122-132. doi:10.1124/dmd.109.028688

DOI: 10.1124/dmd.109.028688

The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes (Journal article)

Janneh, O., Owen, A., Bray, P. G., Back, D. J., & Pirmohamed, M. (2010). The accumulation and metabolism of zidovudine in 3T3-F442A pre-adipocytes. BRITISH JOURNAL OF PHARMACOLOGY, 159(2), 484-493. doi:10.1111/j.1476-5381.2009.00552.x

DOI: 10.1111/j.1476-5381.2009.00552.x

The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation (Journal article)

Fleeman, N., McLeod, C., Bagust, A., Beale, S., Boland, A., Dundar, Y., . . . Dickson, R. (2010). The clinical effectiveness and cost-effectiveness of testing for cytochrome P450 polymorphisms in patients with schizophrenia treated with antipsychotics: a systematic review and economic evaluation. HEALTH TECHNOLOGY ASSESSMENT, 14(3), 1-+. doi:10.3310/hta14030

DOI: 10.3310/hta14030

2009

Effects of genetic variation at the CYP219/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians (Journal article)

Janha, R. E., Sisay-Joof, F., Hamid-Adiamoh, M., Worwui, A., Chapman, H. L., Opara, H., . . . Walton, R. T. (2009). Effects of genetic variation at the CYP219/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians. PHARMACOGENOMICS, 10(9), 1423-1431. doi:10.2217/PGS.09.72

DOI: 10.2217/PGS.09.72

Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design (Journal article)

van Schie, R. M. F., Wadelius, M., Kamali, F., Daly, A. K., Manolopoulos, V. G., de Boer, A., . . . Maitland-van der Zee, A. -H. (2009). Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design. PHARMACOGENOMICS, 10(10), 1687-1695. doi:10.2217/PGS.09.125

DOI: 10.2217/PGS.09.125

The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy (Journal article)

Adetunji, O. R., MacFarlane, I. A., Javadpour, M., Alfirevic, A., Pirmohamed, M., & Blair, J. C. (2009). The d3/fl-GH receptor gene polymorphism does not influence quality of life and body composition in GH-deficient adults receiving GH replacement therapy. EUROPEAN JOURNAL OF ENDOCRINOLOGY, 161(4), 541-546. doi:10.1530/EJE-09-0405

DOI: 10.1530/EJE-09-0405

CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS (Conference Paper)

Mirza, N. S., Pirmohamed, M., & Marson, A. G. (2009). CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 80. doi:10.1136/jnnp.2009.191775i

DOI: 10.1136/jnnp.2009.191775i

Effect of topiramate on acid-base balance: extent, mechanism and effects (Journal article)

Mirza, N., Marson, A. G., & Pirmohamed, M. (2009). Effect of topiramate on acid-base balance: extent, mechanism and effects. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 68(5), 655-661. doi:10.1111/j.1365-2125.2009.03521.x

DOI: 10.1111/j.1365-2125.2009.03521.x

Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo (Journal article)

Jenkins, R. E., Meng, X., Elliott, V. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (2009). Characterisation of flucloxacillin and 5-hydroxymethyl flucloxacillin haptenated HSA in vitro and in vivo. PROTEOMICS CLINICAL APPLICATIONS, 3(6), 720-729. doi:10.1002/prca.200800222

DOI: 10.1002/prca.200800222

Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data (vol 360, pg 753, 2009) (Journal article)

Klein, T. E., Altman, R. B., Eriksson, N., Gage, B. F., Kimmel, S. E., Lee, M. T. M., . . . Shin, J. G. (2009). Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data (vol 360, pg 753, 2009). NEW ENGLAND JOURNAL OF MEDICINE, 361(16), 1613. Retrieved from http://gateway.webofknowledge.com/

CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS (Conference Paper)

Mirza, N., Marson, A., & Pirmohamed, M. (2009). CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS. In EPILEPSIA Vol. 50 (pp. 109). Retrieved from http://gateway.webofknowledge.com/

Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy (Journal article)

Zhang, J. E., Jorgensen, A. L., Alfirevic, A., Williamson, P. R., Toh, C. H., Park, B. K., & Pirmohamed, M. (2009). Effects of CYP4F2 genetic polymorphisms and haplotypes on clinical outcomes in patients initiated on warfarin therapy. PHARMACOGENETICS AND GENOMICS, 19(10), 781-789. doi:10.1097/FPC.0b013e3283311347

DOI: 10.1097/FPC.0b013e3283311347

Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study (Journal article)

Jorgensen, A. L., Al-Zubiedi, S., Zhang, J. E., Keniry, A., Hanson, A., Hughes, D. A., . . . Pirmohamed, M. (2009). Genetic and environmental factors determining clinical outcomes and cost of warfarin therapy: a prospective study. PHARMACOGENETICS AND GENOMICS, 19(10), 800-812. doi:10.1097/FPC.0b013e3283317ab5

DOI: 10.1097/FPC.0b013e3283317ab5

Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers (Journal article)

Musumba, C., Pritchard, D. M., & Pirmohamed, M. (2009). Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 30(6), 517-531. doi:10.1111/j.1365-2036.2009.04086.x

DOI: 10.1111/j.1365-2036.2009.04086.x

Inflammatory Stress and Idiosyncratic Hepatotoxicity: Hints from Animal Models (Journal article)

Deng, X., Luyendyk, J. P., Ganey, P. E., & Roth, R. A. (2009). Inflammatory Stress and Idiosyncratic Hepatotoxicity: Hints from Animal Models. Pharmacological Reviews, 61(3), 262-282. doi:10.1124/pr.109.001727

DOI: 10.1124/pr.109.001727

Spontaneous Hemothorax Following Anticoagulation with Low-Molecular-Weight Heparin (Journal article)

Ganguli, A., Walker, L., FitzGerald, R. J., & Pirmohamed, M. (2009). Spontaneous Hemothorax Following Anticoagulation with Low-Molecular-Weight Heparin. ANNALS OF PHARMACOTHERAPY, 43(9), 1528-1531. doi:10.1345/aph.1L542

DOI: 10.1345/aph.1L542

ANTICIPATING ADVERSE DRUG REACTIONS (Conference Paper)

Pirmohamed, M. (2009). ANTICIPATING ADVERSE DRUG REACTIONS. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 105 (pp. 3). Retrieved from http://gateway.webofknowledge.com/

Bioactivation of nevirapine: characterization and quantification of nevirapine mercapturate in human urine (Journal article)

Srivastava, A., Williams, D. P., Maggs, J. L., Lian, L. Y., Gardner, I., Chaponda, M., . . . Park, B. K. (2009). Bioactivation of nevirapine: characterization and quantification of nevirapine mercapturate in human urine. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 68(2), 276-277. Retrieved from http://gateway.webofknowledge.com/

CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS (Conference Paper)

Mirza, N., Marson, A. G., & Pirmohamed, M. (2009). CARBONIC ANHYDRASE INHIBITOR-INDUCED RENAL TUBULAR ACIDOSIS. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 105 (pp. 84). Retrieved from http://gateway.webofknowledge.com/

Clinical management of HIV-associated lipodystrophy (Journal article)

Pirmohamed, M. (2009). Clinical management of HIV-associated lipodystrophy. CURRENT OPINION IN LIPIDOLOGY, 20(4), 309-314. doi:10.1097/MOL.0b013e32832d3bb1

DOI: 10.1097/MOL.0b013e32832d3bb1

EMERGENCY READMISSIONS TO HOSPITAL DUE TO ADVERSE DRUG REACTIONS (ADRS): A RETROSPECTIVE STUDY (Conference Paper)

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2009). EMERGENCY READMISSIONS TO HOSPITAL DUE TO ADVERSE DRUG REACTIONS (ADRS): A RETROSPECTIVE STUDY. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 105 (pp. 34). Retrieved from http://gateway.webofknowledge.com/

Measurement of lymphocyte proliferation and cytokine secretion from para-phenylenediamine allergic patients and tolerant individuals (Conference Paper)

Jenkinson, C., Aleksic, M., Lavergne, S. N., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2009). Measurement of lymphocyte proliferation and cytokine secretion from para-phenylenediamine allergic patients and tolerant individuals. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 68 (pp. 280). Retrieved from http://gateway.webofknowledge.com/

Characterization and Quantification of Mercapturate and Glutathione Conjugates of Nevirapine (Conference Paper)

Srivastava, A., Williams, D. P., Maggs, J. L., Lian, L. -Y., Chaponda, M., Gardner, I., . . . Park, K. (2009). Characterization and Quantification of Mercapturate and Glutathione Conjugates of Nevirapine. In TOXICOLOGY Vol. 262 (pp. 6-7). doi:10.1016/j.tox.2009.04.051

DOI: 10.1016/j.tox.2009.04.051

Involvement of drug-specific CD4(+) and CD8(+) T-cells in trimethoprim-mediated hepatitis (Conference Paper)

El-Ghaiesh, S., Lavergne, S., Farell, J., Syn, W., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2009). Involvement of drug-specific CD4(+) and CD8(+) T-cells in trimethoprim-mediated hepatitis. In TOXICOLOGY Vol. 262 (pp. 12). doi:10.1016/j.tox.2009.04.010

DOI: 10.1016/j.tox.2009.04.010

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review (Journal article)

Carr, D. F., Whiteley, G., Alfirevic, A., Pirmohamed, M., & Team, F. S. (2009). Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review. PHARMACOGENOMICS JOURNAL, 9(5), 291-305. doi:10.1038/tpj.2009.29

DOI: 10.1038/tpj.2009.29

HLA-B(star)5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin (Journal article)

Daly, A. K., Donaldson, P. T., Bhatnagar, P., Shen, Y., Pe'er, I., Floratos, A., . . . Consortium, I. S. A. E. (2009). HLA-B(star)5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. NATURE GENETICS, 41(7), 816-U71. doi:10.1038/ng.379

DOI: 10.1038/ng.379

TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole (Journal article)

Alfirevic, A., Vilar, F. J., Alsbou, M., Jawaid, A., Thomson, W., Ollier, W. E. R., . . . Pirmohamed, M. (2009). TNF, LTA, HSPA1L and HLA-DR gene polymorphisms in HIV-positive patients with hypersensitivity to cotrimoxazole. PHARMACOGENOMICS, 10(4), 531-540. doi:10.2217/PGS.09.6

DOI: 10.2217/PGS.09.6

A STUDY OF PLASMA LEVELS OF IMATINIB AND ITS BIOACTIVE METABOLITE CGP-74588 REVEALS NO CORRELATION WITH SUBSEQUENT CLINICAL OUTCOME IN IMATINIB-TREATED CHRONIC MYELOID LEUKAEMIA (Conference Paper)

Davies, A., Hayes, A. K., Giannoudis, A., Lucas, C. M., Knight, K., Watmough, S. J., . . . Clark, R. E. (2009). A STUDY OF PLASMA LEVELS OF IMATINIB AND ITS BIOACTIVE METABOLITE CGP-74588 REVEALS NO CORRELATION WITH SUBSEQUENT CLINICAL OUTCOME IN IMATINIB-TREATED CHRONIC MYELOID LEUKAEMIA. In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL Vol. 94 (pp. 259). Retrieved from http://gateway.webofknowledge.com/

In Vivo and In Vitro Efficacy of Amodiaquine against Plasmodium falciparum in an Area of Continued Use of 4-Aminoquinolines in East Africa (Journal article)

Sasi, P., Abdulrahaman, A., Mwai, L., Muriithi, S., Straimer, J., Schieck, E., . . . Borrmann, S. (2009). In Vivo and In Vitro Efficacy of Amodiaquine against Plasmodium falciparum in an Area of Continued Use of 4-Aminoquinolines in East Africa. JOURNAL OF INFECTIOUS DISEASES, 199(11), 1575-1582. doi:10.1086/598862

DOI: 10.1086/598862

RELEASE OF INTRACELLULAR CALCIUM PRIMES CHRONIC MYELOID LEUKAEMIA CELLS FOR TYROSINE KINASE INHIBITOR -INDUCED APOPTOSIS (Conference Paper)

Forchap, S. L., Pirmohamed, M., & Clark, R. E. (2009). RELEASE OF INTRACELLULAR CALCIUM PRIMES CHRONIC MYELOID LEUKAEMIA CELLS FOR TYROSINE KINASE INHIBITOR -INDUCED APOPTOSIS. In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL Vol. 94 (pp. 257). Retrieved from http://gateway.webofknowledge.com/

IMPACT OF PHARMACOGENETICS ON THE COSTS OF MANAGING ADVERSE EVENTS WITH WARFARIN: A PROSPECTIVE ANALYSIS (Journal article)

Hughes, D. A., Al-Zubiedi, S., Hanson, A., Jorgensen, A., & Pirmohamed, M. (2009). IMPACT OF PHARMACOGENETICS ON THE COSTS OF MANAGING ADVERSE EVENTS WITH WARFARIN: A PROSPECTIVE ANALYSIS. VALUE IN HEALTH, 12(3), A3-A4. doi:10.1016/S1098-3015(10)73081-3

DOI: 10.1016/S1098-3015(10)73081-3

Erratum to: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial (Journal article)

Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Erratum to: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial. BMC Psychiatry, 9(1). doi:10.1186/1471-244x-9-14

DOI: 10.1186/1471-244x-9-14

Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial (vol 7, pg 65, 2008) (Journal article)

Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial (vol 7, pg 65, 2008). BMC PSYCHIATRY, 9. doi:10.1186/1471-244X-9-14

DOI: 10.1186/1471-244X-9-14

Adipogenic gene variants in patients with HIV-associated lipodystrophy (Conference Paper)

Pushpakom, S., Owen, A., Vilar, J., Back, D., & Pirmohamed, M. (2009). Adipogenic gene variants in patients with HIV-associated lipodystrophy. In HIV MEDICINE Vol. 10 (pp. 1). Retrieved from http://gateway.webofknowledge.com/

Nevirapine hypersensitivity in Malawi: a prospective cohort study (Conference Paper)

Chaponda, M., Khoo, S. H., Oosterhout, J. V., Kumwenda, J., Lalloo, D., & Pirmohamed, M. (2009). Nevirapine hypersensitivity in Malawi: a prospective cohort study. In HIV MEDICINE Vol. 10 (pp. 34-35). Retrieved from http://gateway.webofknowledge.com/

Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data (Journal article)

Klein, T. E., Altman, R. B., Eriksson, N., Gage, B. F., Kimmel, S. E., Lee, M. -T. M., . . . Cons, I. W. P. (2009). Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data. NEW ENGLAND JOURNAL OF MEDICINE, 360(8), 753-764. Retrieved from http://gateway.webofknowledge.com/

Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes (Journal article)

Davies, E. C., Green, C. F., Taylor, S., Williamson, P. R., Mottram, D. R., & Pirmohamed, M. (2009). Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes. PLOS ONE, 4(2). doi:10.1371/journal.pone.0004439

DOI: 10.1371/journal.pone.0004439

Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GA(2)LEN platform. The Galenda project (Journal article)

Bousquet, P. -J., Demoly, P., Romano, A., Aberer, W., Bircher, A., Blanca, M., . . . ENDA. (2009). Pharmacovigilance of drug allergy and hypersensitivity using the ENDA-DAHD database and the GA(2)LEN platform. The Galenda project. ALLERGY, 64(2), 194-203. doi:10.1111/j.1398-9995.2008.01944.x

DOI: 10.1111/j.1398-9995.2008.01944.x

Correction: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial (Journal article)

Roberts, S. H., Bedson, E., Hughes, D. A., Lloyd, K. R., Menkes, D. B., Moat, S. J., . . . Russell, I. T. (2009). Correction: Folate Augmentation of Treatment – Evaluation for Depression (FolATED): protocol of a randomised controlled trial. BMC psychiatry, 9, 14.

Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters (Journal article)

Davies, A., Jordanides, N. E., Giannoudis, A., Lucas, C. M., Hatziieremia, S., Harris, R. J., . . . Mountford, J. C. (2009). Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters. LEUKEMIA, 23(11), 1999-2006. doi:10.1038/leu.2009.166

DOI: 10.1038/leu.2009.166

The applications of pharmacogenetics to prescribing: what is currently practicable? (Journal article)

Pirmohamed, M. (2009). The applications of pharmacogenetics to prescribing: what is currently practicable?. CLINICAL MEDICINE, 9(5), 493-495. doi:10.7861/clinmedicine.9-5-493

DOI: 10.7861/clinmedicine.9-5-493

2008

Pharmacogenetics of adverse drug reactions: A pharmacovigilance perspective (Journal article)

Alfirevic, A., & Pirmohamed, M. (2008). Pharmacogenetics of adverse drug reactions: A pharmacovigilance perspective. Journal of Applied Therapeutic Research, 6(3), 3-8.

Genetic variants of hepatic transporters and susceptibility to drug induced liver injury (Conference Paper)

Bhatnagar, P., Day, C. P., Aithal, G., Pirmohamed, M., Bernal, W., & Daly, A. K. (2008). Genetic variants of hepatic transporters and susceptibility to drug induced liver injury. In TOXICOLOGY Vol. 253 (pp. 10). doi:10.1016/j.tox.2008.07.008

DOI: 10.1016/j.tox.2008.07.008

Nilotinib concentration in Cell Lines and CML CD34+Cells Is Not Mediated by Active Uptake or Efflux by Major Drug Transporters (Conference Paper)

Mountford, J., Davies, A., Jordanides, N. E., Giannoudis, A., Lucas, C. M., Hatziieremia, S., . . . Clark, R. E. (2008). Nilotinib concentration in Cell Lines and CML CD34+Cells Is Not Mediated by Active Uptake or Efflux by Major Drug Transporters. In BLOOD Vol. 112 (pp. 1100). Retrieved from http://gateway.webofknowledge.com/

Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia (Journal article)

Giannoudis, A., Davies, A., Lucas, C. M., Harris, R. J., Pirmohamed, M., & Clark, R. E. (2008). Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia. BLOOD, 112(8), 3348-3354. doi:10.1182/blood-2007-10-116236

DOI: 10.1182/blood-2007-10-116236

HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options (Journal article)

Mallewa, J. E., Wilkins, E., Vilar, J., Mallewa, M., Doran, D., Back, D., & Pirmohamed, M. (2008). HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 62(4), 648-660. doi:10.1093/jac/dkn251

DOI: 10.1093/jac/dkn251

FLUCLOXACILLIN-INDUCED LIVER INJURY: THE EXTENDED MHC 57.1 HAPLOTYPE AS A MAJOR RISK FACTOR (Conference Paper)

Donaldson, P. T., Bhatnagar, P., Graham, J., Henderson, J., Leathart, J. B., Pirmohamed, M., . . . Daly, A. K. (2008). FLUCLOXACILLIN-INDUCED LIVER INJURY: THE EXTENDED MHC 57.1 HAPLOTYPE AS A MAJOR RISK FACTOR. In HEPATOLOGY Vol. 48 (pp. 396A-397A). Retrieved from http://gateway.webofknowledge.com/

SUSCEPTIBILITY TO DRUG INDUCED LIVER INJURY DETERMINED BY HLA CLASS II GENOTYPE (Conference Paper)

Donaldson, P. T., Bhatnagar, P., Graham, J., Henderson, J., Leathart, J. B., Pirmohamed, M., . . . Day, C. P. (2008). SUSCEPTIBILITY TO DRUG INDUCED LIVER INJURY DETERMINED BY HLA CLASS II GENOTYPE. In HEPATOLOGY Vol. 48 (pp. 464A). Retrieved from http://gateway.webofknowledge.com/

The use of opioids and laxatives, and incidence of constipation, in patients requiring neck-of-femur (NOF) surgery: a pilot study (Journal article)

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2008). The use of opioids and laxatives, and incidence of constipation, in patients requiring neck-of-femur (NOF) surgery: a pilot study. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 33(5), 561-566. doi:10.1111/j.1365-2710.2008.00949.x

DOI: 10.1111/j.1365-2710.2008.00949.x

A prospective study to examine the use of opioids and laxatives, and the prevalence of constipation in patients requiring emergency neck of femur (NOF) surgery (Conference Paper)

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2008). A prospective study to examine the use of opioids and laxatives, and the prevalence of constipation in patients requiring emergency neck of femur (NOF) surgery. In PHARMACY WORLD & SCIENCE Vol. 30 (pp. 460-461). Retrieved from http://gateway.webofknowledge.com/

Adverse drug reactions in hospital inpatients: a prospective study (Conference Paper)

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2008). Adverse drug reactions in hospital inpatients: a prospective study. In PHARMACY WORLD & SCIENCE Vol. 30 (pp. 458-459). Retrieved from http://gateway.webofknowledge.com/

The burden of Adverse Drug Reactions (ADRs) on hospital inpatients - a pilot study (Conference Paper)

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2008). The burden of Adverse Drug Reactions (ADRs) on hospital inpatients - a pilot study. In PHARMACY WORLD & SCIENCE Vol. 30 (pp. 392-393). Retrieved from http://gateway.webofknowledge.com/

Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes (Journal article)

Jones, S. P., Waitt, C., Sutton, R., Back, D. J., & Pirmohamed, M. (2008). Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes. AIDS, 22(11), 1293-1298. doi:10.1097/QAD.0b013e3283021a4f

DOI: 10.1097/QAD.0b013e3283021a4f

Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes (Journal article)

DOI: 10.1097/qad.0b013e3283021a4f

Drug metabolism (Journal article)

Pirmohamed, M. (2008). Drug metabolism. Medicine, 36(7), 355-359. doi:10.1016/j.mpmed.2008.04.002

DOI: 10.1016/j.mpmed.2008.04.002

Comparison of the functional characteristics of allergic and tolerant patient lymphocytes stimulated with p-phenylenediamine and Bandrowski's base (Conference Paper)

Coulter, E. M., Pease, C. K., White, A., Lockley, D., Basketter, D., Williams, D. P., . . . Naisbitt, D. J. (2008). Comparison of the functional characteristics of allergic and tolerant patient lymphocytes stimulated with p-phenylenediamine and Bandrowski's base. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 982-984). Retrieved from http://gateway.webofknowledge.com/

MEASUREMENT OF IMATINIB AND ITS METABOLITE, CGP-74588, IN TREATED CHRONIC MYELOID LEUKAEMIA PATEINTS BY HPLC (Conference Paper)

Davies, A., Hayes, A., Knight, K., Watmough, S. J., Pirmohamed, M., & Clark, R. E. (2008). MEASUREMENT OF IMATINIB AND ITS METABOLITE, CGP-74588, IN TREATED CHRONIC MYELOID LEUKAEMIA PATEINTS BY HPLC. In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL Vol. 93 (pp. 52). Retrieved from http://gateway.webofknowledge.com/

Metabolic activation of nevirapine in human and rat systems (Conference Paper)

Srivastava, A., Maggs, J. L., Pirmohamed, M., Park, B. K., & Williams, D. P. (2008). Metabolic activation of nevirapine in human and rat systems. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 1001-1002). Retrieved from http://gateway.webofknowledge.com/

THE HUMAN ORGANIC CATION TRANSPORTER I HAS MINIMAL IMPACT IN THE UPTAKE OF DASATINIB INTO CHRONIC MYELOID LEUKAEMIA PRIMARY CELLS AND CELL LINES (Conference Paper)

Giannoudis, A., Lucas, C. M., Davies, A., Harris, R. J., Pirmohamed, M., & Clark, R. E. (2008). THE HUMAN ORGANIC CATION TRANSPORTER I HAS MINIMAL IMPACT IN THE UPTAKE OF DASATINIB INTO CHRONIC MYELOID LEUKAEMIA PRIMARY CELLS AND CELL LINES. In HAEMATOLOGICA-THE HEMATOLOGY JOURNAL Vol. 93 (pp. 312). Retrieved from http://gateway.webofknowledge.com/

The pharmacokinetic profile of warfarin: a systematic review (Conference Paper)

Al-Zubiedi, S., Hughes, D., & Pirmohamed, M. (2008). The pharmacokinetic profile of warfarin: a systematic review. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 1002-1003). Retrieved from http://gateway.webofknowledge.com/

p-Phenylenediamine-bound irreversibly to cysteine residues on human serum albumin activates T-cells from patients allergic to hair dye (Conference Paper)

Jenkinson, C., Jenkins, R. E., Pease, C. K., Kitteringham, N. R., Aleksic, M., Pirmohamed, M., . . . Naisbitt, D. J. (2008). p-Phenylenediamine-bound irreversibly to cysteine residues on human serum albumin activates T-cells from patients allergic to hair dye. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 65 (pp. 984). Retrieved from http://gateway.webofknowledge.com/

Important questions in Allergy: 1-drug allergy/hypersensitivity (Journal article)

Demoly, P., Pichler, W., Pirmohamed, M., & Romano, A. (2008). Important questions in Allergy: 1-drug allergy/hypersensitivity. ALLERGY, 63(5), 616-619. doi:10.1111/j.1398-9995.2008.01693.x

DOI: 10.1111/j.1398-9995.2008.01693.x

Interpreting adverse drug reaction reports as hospital patient safety incidents (Journal article)

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2008). Interpreting adverse drug reaction reports as hospital patient safety incidents. International Journal of Pharmacy Practice, 16(SUPPL. 1).

Dasatinib uptake into chronic myeloid leukaemia cells is independent of hOCT1 expression, in contrast to imatinib (Conference Paper)

Giannoudis, A., Davies, A., Lucas, C. M., Harris, R. J., Pirmohamed, M., & Clark, R. E. (2008). Dasatinib uptake into chronic myeloid leukaemia cells is independent of hOCT1 expression, in contrast to imatinib. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 141 (pp. 41). Retrieved from http://gateway.webofknowledge.com/

Development of an isocratic UV-HPLC method to measure imatinib and its metabolite, CGP-74 588, in chronic myeloid leukaemia (CML) patients (Conference Paper)

Davies, A., Hayes, A., Knight, K., Watmough, S. J., & Pirmohamed, M. (2008). Development of an isocratic UV-HPLC method to measure imatinib and its metabolite, CGP-74 588, in chronic myeloid leukaemia (CML) patients. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 141 (pp. 49-50). Retrieved from http://gateway.webofknowledge.com/

Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia (Journal article)

Clark, R. E., Davies, A., Pirmohamed, M., & Giannoudis, A. (2008). Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia. LEUKEMIA & LYMPHOMA, 49(4), 639-642. doi:10.1080/10428190701858823

DOI: 10.1080/10428190701858823

Unlike imatinib, nilotinib transport into chronic myeloid leukaemia cells is not dependent on hOCT1 expression (Conference Paper)

Davies, A., Giannoudis, A., Lucas, C. M., Harris, R. J., Manley, P. W., Pirmohamed, M., & Clark, R. E. (2008). Unlike imatinib, nilotinib transport into chronic myeloid leukaemia cells is not dependent on hOCT1 expression. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 141 (pp. 41-42). Retrieved from http://gateway.webofknowledge.com/

Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia (Journal article)

Wang, L., Giannoudis, A., Lane, S., Williamson, P., Pirmohamed, M., & Clark, R. E. (2008). Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia. CLINICAL PHARMACOLOGY & THERAPEUTICS, 83(2), 258-264. doi:10.1038/sj.clpt.6100268

DOI: 10.1038/sj.clpt.6100268

Activation of T-Cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base (Journal article)

Coulter, E. M., Jenkinson, C., Wu, Y., Farrell, J., Foster, B., Smith, A., . . . Naisbitt, D. J. (2008). Activation of T-Cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 128(4), 897-905. doi:10.1038/sj.jid.5701071

DOI: 10.1038/sj.jid.5701071

Adverse drug reactions and pharmacogenomics: recent advances (Journal article)

Alfirevic, A., & Pirmohamed, M. (2008). Adverse drug reactions and pharmacogenomics: recent advances. PERSONALIZED MEDICINE, 5(1), 11-23. doi:10.2217/17410541.5.1.11

DOI: 10.2217/17410541.5.1.11

Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia (Journal article)

Wang, L., Giannoudis, A., Lane, S., Williamson, P., Pirmohamed, M., & Clark, R. E. (2008). Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia. Clinical Pharmacology and Therapeutics, 83(2), 258-264. doi:10.1038/sj.clpt.6100268

DOI: 10.1038/sj.clpt.6100268

Paediatric Pharmacogenomics - Challenges and Opportunities. 2008; 2(1): 13-15 (Journal article)

Hawcutt, D. B., & Pirmohamed, M. (2008). Paediatric Pharmacogenomics - Challenges and Opportunities. 2008; 2(1): 13-15. European Paediatrics, 2(1), 13-15.

2007

Investigation into the multidimensional genetic basis of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (Journal article)

Pirmohamed, M., Arbuckle, J. B., Bowman, C. E., Brunner, M., Burns, D. K., Delrieu, O., . . . Stern, R. S. (2007). Investigation into the multidimensional genetic basis of drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis. PHARMACOGENOMICS, 8(12), 1661-1691. doi:10.2217/14622416.8.12.1661

DOI: 10.2217/14622416.8.12.1661

Tacrine-induced liver damage: an analysis of 19 candidate genes (Journal article)

Alfirevic, A., Mills, T., Carr, D., Barratt, B. J., Jawaid, A., Sherwood, J., . . . Pirmohamed, M. (2007). Tacrine-induced liver damage: an analysis of 19 candidate genes. PHARMACOGENETICS AND GENOMICS, 17(12), 1091-1100. doi:10.1097/FPC.0b013e3282f1f12b

DOI: 10.1097/FPC.0b013e3282f1f12b

The association between polymorphisms in RLIP76 and drug response in epilepsy (Journal article)

Leschziner, G. D., Jorgensen, A. L., Andrews, T., Williamson, P. R., Marson, A. G., Coffey, A. J., . . . Pirmohamed, M. (2007). The association between polymorphisms in RLIP76 and drug response in epilepsy. PHARMACOGENOMICS, 8(12), 1715-1722. doi:10.2217/14622416.8.12.1715

DOI: 10.2217/14622416.8.12.1715

Characterisation of nilotinib transport in chronic myeloid leukaemia cells (Conference Paper)

Davies, A., Giannoudis, A., Lucas, C. M., Harris, R. J., Manley, P. W., Pirmohamed, M., & Clark, R. E. (2007). Characterisation of nilotinib transport in chronic myeloid leukaemia cells. In BLOOD Vol. 110 (pp. 698A). Retrieved from http://gateway.webofknowledge.com/

Unlike imatinib, dasatinib uptake into chronic myeloid leukaemia cells is independent of hOCT1 expression (Conference Paper)

Giannoudis, A., Davies, A., Lucas, C. M., Harris, R. J., Pirmohamed, M., & Clark, R. E. (2007). Unlike imatinib, dasatinib uptake into chronic myeloid leukaemia cells is independent of hOCT1 expression. In BLOOD Vol. 110 (pp. 1013A-1014A). doi:10.1182/blood.V110.11.3458.3458

DOI: 10.1182/blood.V110.11.3458.3458

Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial (Journal article)

Roberts, S. H., Bedson, E., Hughes, D., Lloyd, K., Moat, S., Pirmohamed, M., . . . Russell, I. (2007). Folate Augmentation of Treatment-Evaluation for Depression (FolATED): protocol of a randomised controlled trial. BMC PSYCHIATRY, 7. doi:10.1186/1471-244X-7-65

DOI: 10.1186/1471-244X-7-65

Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity (Journal article)

Carr, D. F., Alfirevic, A., Tugwood, J. D., Barratt, B. J., Sherwood, J., Smith, J., . . . Park, B. K. (2007). Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity. PHARMACOGENETICS AND GENOMICS, 17(11), 961-972. doi:10.1097/FPC.0b013e3282f00919

DOI: 10.1097/FPC.0b013e3282f00919

Platelet inhibition and myocardial necrosis in elective coronary artery stenting (Conference Paper)

Wiper, A., Anantharanan, R., Schmitt, M., Brack, M., Chauhan, A., Eccleshall, S., . . . Roberts, D. H. (2007). Platelet inhibition and myocardial necrosis in elective coronary artery stenting. In AMERICAN JOURNAL OF CARDIOLOGY Vol. 100 (pp. 181L). Retrieved from http://gateway.webofknowledge.com/

Pharmacogenetics: current status, future challenges (Conference Paper)

Pirmohamed, M. (2007). Pharmacogenetics: current status, future challenges. In ACTA PAEDIATRICA Vol. 96 (pp. 166-167). Retrieved from http://gateway.webofknowledge.com/

Pharmacovigilance in developing countries - Requires collaboration between stakeholders to develop novel models of funding (Journal article)

Pirmohamed, M., Atuah, K. N., Dodoo, A. N. O., & Winstanley, P. (2007). Pharmacovigilance in developing countries - Requires collaboration between stakeholders to develop novel models of funding. BRITISH MEDICAL JOURNAL, 335(7618), 462. doi:10.1136/bmj.39323.586123.BE

DOI: 10.1136/bmj.39323.586123.BE

Platelet function and peri-procedural myocardial necrosis in elective Percutaneous Coronary Intervention (ePCI) (Conference Paper)

Wiper, A., Schmitt, M., Brack, M., Eccleshall, S., Goode, G., More, R., . . . Roberts, D. H. (2007). Platelet function and peri-procedural myocardial necrosis in elective Percutaneous Coronary Intervention (ePCI). In EUROPEAN HEART JOURNAL Vol. 28 (pp. 268). Retrieved from http://gateway.webofknowledge.com/

Current assessment of risk-benefit by regulators: Is it time to introduce decision analyses? (Journal article)

Hughes, D. A., Bayoumi, A. M., & Pirmohamed, M. (2007). Current assessment of risk-benefit by regulators: Is it time to introduce decision analyses?. CLINICAL PHARMACOLOGY & THERAPEUTICS, 82(2), 123-127. doi:10.1038/sj.clpt.6100240

DOI: 10.1038/sj.clpt.6100240

Current assessment of risk-benefit by regulators: is it time to introduce decision analyses? (Journal article)

Hughes, D. A., Bayoumi, A. M., & Pirmohamed, M. (2007). Current assessment of risk-benefit by regulators: is it time to introduce decision analyses?. Clinical pharmacology and therapeutics, 82(2), 123-127. doi:10.1038/sj.clpt.6100240

DOI: 10.1038/sj.clpt.6100240

Prediction of metabolic clearance: CYP2C9 genotyping in epileptic subjects receiving phenytoin (Conference Paper)

Horman, A. J., Sathasivam, S., Pirmohamed, M., Marson, A., Chadwick, D. W., & Watson, I. D. (2007). Prediction of metabolic clearance: CYP2C9 genotyping in epileptic subjects receiving phenytoin. In THERAPEUTIC DRUG MONITORING Vol. 29 (pp. 546). Retrieved from http://gateway.webofknowledge.com/

ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research (Journal article)

Leschziner, G. D., Andrew, T., Pirmohamed, M., & Johnson, M. R. (2007). ABCB1 genotype and PGP expression, function and therapeutic drug response: a critical review and recommendations for future research. PHARMACOGENOMICS JOURNAL, 7(3), 154-179. doi:10.1038/sj.tpj.6500413

DOI: 10.1038/sj.tpj.6500413

Genetics of epilepsy: Epilepsy Research Foundation Workshop Report - Abstracts (Journal article)

Sisodiya, S. (2007). Genetics of epilepsy: Epilepsy Research Foundation Workshop Report - Abstracts. EPILEPTIC DISORDERS, 9(2), 194-236. doi:10.1684/epd.2007.0107

DOI: 10.1684/epd.2007.0107

Metformin decreases serum B-12 concentrations in a dose-dependent fashion. Is there a case for routine monitoring? (Conference Paper)

Constable, S., Lane, S., Vora, J., Edwards, G., Williamson, P., & Pirmohamed, M. (2007). Metformin decreases serum B-12 concentrations in a dose-dependent fashion. Is there a case for routine monitoring?. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 63 (pp. 791). Retrieved from http://gateway.webofknowledge.com/

This is the drug for you, Madam! (Conference Paper)

Pirmohamed, M. (2007). This is the drug for you, Madam!. In Epileptic Disorders Vol. 9 (pp. 233-234).

HIV and Drug Hypersensitivity (Chapter)

Pirmohamed, M. (2007). HIV and Drug Hypersensitivity. In Drug Hypersensitivity (pp. 84-94). KARGER. doi:10.1159/000104192

DOI: 10.1159/000104192

Drug hypersensitivity reactions in patients with HIV disease. (Journal article)

Pirmohamed, M., Drummond, N. S., Naisbitt, D. J., & Park, B. K. (2007). Drug hypersensitivity reactions in patients with HIV disease.. Expert review of clinical immunology, 3(3), 395-410. doi:10.1586/1744666x.3.3.395

DOI: 10.1586/1744666x.3.3.395

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling (Journal article)

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Ashby, C. A., Tucker, M. J., Rieder, M. J., . . . Park, B. K. (2007). Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. JOURNAL OF IMMUNOLOGY, 178(9), 5533-5542. doi:10.4049/jimmunol.178.9.5533

DOI: 10.4049/jimmunol.178.9.5533

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling (Journal article)

An association study of common SNPs in SREBP-2 and SCAP genes with simvastatin response in Saudi patients (Conference Paper)

Alzahrani, S., Al-Najai, M., Al-Mohanna, F., Meyer, B., Al-Shaheed, M., Mohammed, G., . . . Dzimiri, N. (2007). An association study of common SNPs in SREBP-2 and SCAP genes with simvastatin response in Saudi patients. In FASEB JOURNAL Vol. 21 (pp. A182-A183). Retrieved from http://gateway.webofknowledge.com/

Generation and characterization of antigen-specific CD4(+), CD8(+), and CD4(+)CD8(+) T-cell clones from patients with carbamazopine hypersensitivity (Journal article)

Wu, Y., Farrell, J., Pirmohmed, M., Park, B. K., & Naisbitt, D. J. (2007). Generation and characterization of antigen-specific CD4(+), CD8(+), and CD4(+)CD8(+) T-cell clones from patients with carbamazopine hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 119(4), 973-981. doi:10.1016/j.jaci.2006.12.617

DOI: 10.1016/j.jaci.2006.12.617

Pharmacogenetics of warfarin: current status and future challenges (Journal article)

Wadelius, M., & Pirmohamed, M. (2007). Pharmacogenetics of warfarin: current status and future challenges. PHARMACOGENOMICS JOURNAL, 7(2), 99-111. doi:10.1038/sj.tpj.6500417

DOI: 10.1038/sj.tpj.6500417

Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach (Journal article)

Leschziner, G. D., Andrew, T., Leach, J. P., Chadwick, D., Coffey, A. J., Balding, D. J., . . . Johnson, M. R. (2007). Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach. PHARMACOGENETICS AND GENOMICS, 17(3), 217-220. doi:10.1097/01.fpc.0000230408.23146.b1

DOI: 10.1097/01.fpc.0000230408.23146.b1

Immunological principles of T-cell-mediated adverse drug reactions in skin (Journal article)

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2007). Immunological principles of T-cell-mediated adverse drug reactions in skin. EXPERT OPINION ON DRUG SAFETY, 6(2), 109-124. doi:10.1517/14740338.6.2.109

DOI: 10.1517/14740338.6.2.109

Immunological principles of T-cell-mediated adverse drug reactions in skin (Journal article)

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2007). Immunological principles of T-cell-mediated adverse drug reactions in skin. Expert Opinion on Drug Safety, 6(2), 109-124. doi:10.1517/14740338.6.2.109

DOI: 10.1517/14740338.6.2.109

Mechanisms of Adverse Drug Reactions (Chapter)

Pirmohamed, M., & Park, B. K. (n.d.). Mechanisms of Adverse Drug Reactions. In Pharmacovigilance (pp. 85-103). John Wiley & Sons, Ltd. doi:10.1002/9780470059210.ch8

DOI: 10.1002/9780470059210.ch8

Herbal medicines and acute medical emergency admissions to hospital (Journal article)

Constable, S., Ham, A., & Pirmohamed, M. (2007). Herbal medicines and acute medical emergency admissions to hospital. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 63(2), 247-248. doi:10.1111/j.1365-2125.2006.02817.x

DOI: 10.1111/j.1365-2125.2006.02817.x

Which drugs cause preventable admissions to hospital? A systematic review (Journal article)

Howard, R. L., Avery, A. J., Slavenburg, S., Royal, S., Pipe, G., Lucassen, P., & Pirmohamed, M. (2007). Which drugs cause preventable admissions to hospital? A systematic review. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 63(2), 136-147. doi:10.1111/j.1365-2125.2006.02698.x

DOI: 10.1111/j.1365-2125.2006.02698.x

Adverse drug reactions in hospitals: a narrative review. (Journal article)

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2007). Adverse drug reactions in hospitals: a narrative review.. Current drug safety, 2(1), 79-87. doi:10.2174/157488607779315507

DOI: 10.2174/157488607779315507

Anticonvulsant agents (Chapter)

Pirmohamed, M., & Leeder, S. J. (2007). Anticonvulsant agents. In Drug-Induced Liver Disease, Second Edition (pp. 485-505).

Common ABCB1 polymorphisms are not associated with multidrug resistance in (Journal article)

Leschziner, G. D., Andrew, T., Leach, J. P., Chadwick, D., Coffey, A. J., Balding, D. J., . . . Johnson, M. R. (2007). Common ABCB1 polymorphisms are not associated with multidrug resistance in. Pharmacogenet Genomics. 2007 217-20., 3(3), 217-220.

Prescribing in liver disease (Journal article)

Pirmohamed, M. (2007). Prescribing in liver disease. Medicine, 35(1), 31-34. doi:10.1053/j.mpmed.2006.10.009

DOI: 10.1053/j.mpmed.2006.10.009

Warfarin Pharmacogenetics (Journal article)

Hughes, D. A., & Pirmohamed, M. (2007). Warfarin Pharmacogenetics. PharmacoEconomics, 25(11), 899-902. doi:10.2165/00019053-200725110-00001

DOI: 10.2165/00019053-200725110-00001

Warfarin pharmacogenetics: Economic considerations (Journal article)

Hughes, D. A., & Pirmohamed, M. (2007). Warfarin pharmacogenetics: Economic considerations. PHARMACOECONOMICS, 25(11), 899-902. doi:10.2165/00019053-200725110-00001

DOI: 10.2165/00019053-200725110-00001

2006

ABCB1 polymorphisms and haplotype previously associated with drug resistant epilepsy have no effect on therapeutic or adverse drug response in a large prospective epilepsy cohort (Conference Paper)

Leschziner, G., Jorgensen, A., Andrew, T., Middleditch, C., Pirmohamed, M., Williamson, P., . . . Johnson, M. R. (2006). ABCB1 polymorphisms and haplotype previously associated with drug resistant epilepsy have no effect on therapeutic or adverse drug response in a large prospective epilepsy cohort. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 77 (pp. 1394). Retrieved from http://gateway.webofknowledge.com/

Clinical and functional evidence that drug transporter expression dictates the response to imatinib in chronic myeloid leukaemia. (Conference Paper)

Wang, L., Giannoudis, A., Lane, S., Williamson, P. R., Pirmohamed, M., & Clark, R. E. (2006). Clinical and functional evidence that drug transporter expression dictates the response to imatinib in chronic myeloid leukaemia.. In BLOOD Vol. 108 (pp. 608A-609A). doi:10.1182/blood.V108.11.2145.2145

DOI: 10.1182/blood.V108.11.2145.2145

Warfarin: almost 60 years old and still causing problems (Journal article)

Pirmohamed, M. (2006). Warfarin: almost 60 years old and still causing problems. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 62(5), 509-511. doi:10.1111/j.1365-2125.2006.02806.x

DOI: 10.1111/j.1365-2125.2006.02806.x

Pharmacogenetics of HIV therapy (Journal article)

Owen, A., Pirmohamed, M., Khoo, S. H., & Back, D. J. (2006). Pharmacogenetics of HIV therapy. PHARMACOGENETICS AND GENOMICS, 16(10), 693-703. doi:10.1097/01.fpc.0000236338.41799.57

DOI: 10.1097/01.fpc.0000236338.41799.57

HLA-B locus in Caucasian patients with carbamazepine hypersensitivity (Journal article)

Alfirevic, A., Jorgensen, A. L., Williamson, P. R., Chadwick, D. W., Park, B. K., & Pirmohamed, M. (2006). HLA-B locus in Caucasian patients with carbamazepine hypersensitivity. PHARMACOGENOMICS, 7(6), 813-818. doi:10.2217/14622416.7.6.813

DOI: 10.2217/14622416.7.6.813

Pharmacogenetics in clinical practice: considerations for testing (Journal article)

Constable, S., Johnson, M. R., & Pirmohamed, M. (2006). Pharmacogenetics in clinical practice: considerations for testing. EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 6(2), 193-205. doi:10.1586/14737159.6.2.193

DOI: 10.1586/14737159.6.2.193

Adverse drug reactions in hospital in-patients: a pilot study (Journal article)

Davies, E. C., Green, C. F., Mottram, D. R., & Pirmohamed, M. (2006). Adverse drug reactions in hospital in-patients: a pilot study. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 31(4), 335-341. doi:10.1111/j.1365-2710.2006.00744.x

DOI: 10.1111/j.1365-2710.2006.00744.x

Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study (Journal article)

Leschziner, G., Jorgensen, A. L., Andrew, T., Pirmohaomed, M., Williamson, P. R., Marson, A. G., . . . Johnson, M. R. (2006). Clinical factors and ABCB1 polymorphisms in prediction of antiepileptic drug response: a prospective cohort study. LANCET NEUROLOGY, 5(8), 668-676. doi:10.1016/S1474-4422(06)70500-2

DOI: 10.1016/S1474-4422(06)70500-2

Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements (Journal article)

Owen, A., Goldring, C., Morgan, P., Park, B. K., & Pirmohamed, M. (2006). Induction of P-glycoprotein in lymphocytes by carbamazepine and rifampicin: the role of nuclear hormone response elements. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 62(2), 237-242. doi:10.1111/j.1365-2125.2006.02587.x

DOI: 10.1111/j.1365-2125.2006.02587.x

Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan (Journal article)

Constable, S., Farrell, J., Naisbitt, D., King, C., Leonard, N., & Pirmohamed, M. (2006). Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan. BRITISH JOURNAL OF DERMATOLOGY, 155(2), 491-493. doi:10.1111/j.1365-2133.2006.07338.x

DOI: 10.1111/j.1365-2133.2006.07338.x

Activation of T cells by carbamazepine and carbamazepine metabolites (Journal article)

Wu, Y., Sanderson, J. P., Farrell, J., Drummond, N. S., Hanson, A., Bowkett, E., . . . Naisbitt, D. J. (2006). Activation of T cells by carbamazepine and carbamazepine metabolites. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 118(1), 233-241. doi:10.1016/j.jaci.2006.03.005

DOI: 10.1016/j.jaci.2006.03.005

Pharmacogenetics: theoretical background and practical problems (Conference Paper)

Pirmohamed, M. (2006). Pharmacogenetics: theoretical background and practical problems. In ACTA PHARMACOLOGICA SINICA Vol. 27 (pp. 46). Retrieved from http://gateway.webofknowledge.com/

Drug-specific T cells in an HIV-positive patient with nevirapine-induced hepatitis (Journal article)

Drummond, N. S., Vilar, F. J., Naisbitt, D. J., Hanson, A., Woods, A., Park, B. K., & Pirmohamed, M. (2006). Drug-specific T cells in an HIV-positive patient with nevirapine-induced hepatitis. ANTIVIRAL THERAPY, 11(3), 393-395. Retrieved from http://gateway.webofknowledge.com/

Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance (Journal article)

Leschziner, G., Zabaneh, D., Pirmohamed, M., Owen, A., Rogers, J., Coffey, A. J., . . . Johnson, M. R. (2006). Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance. PHARMACOGENETICS AND GENOMICS, 16(6), 439-450. doi:10.1097/01.fpc.0000197467.21964.67

DOI: 10.1097/01.fpc.0000197467.21964.67

The future prospects of pharmacogenetics in oral anticoagulation therapy (Journal article)

Kamali, F., & Pirmohamed, M. (2006). The future prospects of pharmacogenetics in oral anticoagulation therapy. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 61(6), 746-751. doi:10.1111/j.1365-2125.2006.02679.x

DOI: 10.1111/j.1365-2125.2006.02679.x

Antibiotic allergy (Journal article)

Eschenauer, G. A., Regal, R. E., & DePestel, D. D. (2006). Antibiotic allergy. NEW ENGLAND JOURNAL OF MEDICINE, 354(21), 2293-2294. Retrieved from http://gateway.webofknowledge.com/

Antibiotic allergy - Reply (Journal article)

Gruchalla, R. S., & Pirmohamed, M. (2006). Antibiotic allergy - Reply. NEW ENGLAND JOURNAL OF MEDICINE, 354(21), 2294. Retrieved from http://gateway.webofknowledge.com/

Stimulant medications and attention deficit-hyperactivity disorder. (Journal article)

Cohen, A. L., Jhung, M. A., & Budnitz, D. S. (2006). Stimulant medications and attention deficit-hyperactivity disorder.. The New England journal of medicine, 354(21), 2294-2295. doi:10.1056/nejmc060860

DOI: 10.1056/nejmc060860

Characterization of cytotoxic CD8+T-cells from carbamazepine hypersensitive patients (Conference Paper)

Wu, Y., Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2006). Characterization of cytotoxic CD8+T-cells from carbamazepine hypersensitive patients. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 632). Retrieved from http://gateway.webofknowledge.com/

Dendritic cell metabolism of sulfamethoxazole leads to increased CD40 expression: a key determinant of immunogenicity (Conference Paper)

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Drummond, N., Mathews, K. L., Pirmohamed, M., . . . Park, B. K. (2006). Dendritic cell metabolism of sulfamethoxazole leads to increased CD40 expression: a key determinant of immunogenicity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 645). Retrieved from http://gateway.webofknowledge.com/

Genetic analysis of tacrine-induced transaminitis (Conference Paper)

Alfirevic, A., Mills, T., Carr, D., Barratt, B. J., Pinel, T., Sherwood, J., . . . Pirmohamed, M. (2006). Genetic analysis of tacrine-induced transaminitis. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 61 (pp. 644). Retrieved from http://gateway.webofknowledge.com/

Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster (Journal article)

Alfirevic, A., Mills, T., Harrington, P., Pinel, T., Sherwood, J., Jawaid, A., . . . Pirmohamed, M. (2006). Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. PHARMACOGENETICS AND GENOMICS, 16(4), 287-296. doi:10.1097/01.fpc.0000189800.88596.7a

DOI: 10.1097/01.fpc.0000189800.88596.7a

Personalized medicine: decades away? (Journal article)

Lunshof, J. E., Pirmohamed, M., & Gurwitz, D. (2006). Personalized medicine: decades away?. PHARMACOGENOMICS, 7(2), 237-241. doi:10.2217/14622416.7.2.237

DOI: 10.2217/14622416.7.2.237

Antibiotic allergy (Journal article)

Gruchalla, R. S., & Pirmohamed, M. (2006). Antibiotic allergy. NEW ENGLAND JOURNAL OF MEDICINE, 354(6), 601-609. doi:10.1056/NEJMcp043986

DOI: 10.1056/NEJMcp043986

Genetic factors in the predisposition to drug-induced hypersensitivity reactions (Journal article)

Pirmohamed, M. (2006). Genetic factors in the predisposition to drug-induced hypersensitivity reactions. AAPS JOURNAL, 8(1), E20-E26. doi:10.1208/aapsj080103

DOI: 10.1208/aapsj080103

ACB1 polymorphisms and haplotype previously associated with drug-resistant epilepsy have no effect on therapeutic or adverse drug response in a large prospective cohort (Conference Paper)

Leschziner, G. D., Jorgensen, A., Andrew, T., Middleditch, C., Pirmohamed, M., Marson, T., . . . Johnson, M. R. (2006). ACB1 polymorphisms and haplotype previously associated with drug-resistant epilepsy have no effect on therapeutic or adverse drug response in a large prospective cohort. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 84). Retrieved from http://gateway.webofknowledge.com/

Adverse drug reactions (ADRS) in hospital in-patients: A prospective analysis of 3772 patients (Conference Paper)

Davies, E. C., Green, C. F., Mottram, D. M., & Pirmohamed, M. (2006). Adverse drug reactions (ADRS) in hospital in-patients: A prospective analysis of 3772 patients. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 179). Retrieved from http://gateway.webofknowledge.com/

Antecedent exercise improves glucose utilization in healthy volunteers treated with a single dose of protease inhibitor (Conference Paper)

Doran, D. A., Jones, S. P., Evans, L., Campbell, I. T., Stokes, D. J., Yates, A. P., . . . MacLaren, D. P. M. (2006). Antecedent exercise improves glucose utilization in healthy volunteers treated with a single dose of protease inhibitor. In ANTIVIRAL THERAPY Vol. 11 (pp. L36). Retrieved from http://gateway.webofknowledge.com/

Beyond registration - measuring the public-health potential of new treatments for malaria in Africa (Journal article)

Lang, T., Hughes, D., Kanyok, T., Kengeya-Kayondo, J., Marsh, V., Haaland, A., . . . Winstanley, P. (2006). Beyond registration - measuring the public-health potential of new treatments for malaria in Africa. LANCET INFECTIOUS DISEASES, 6(1), 46-52. doi:10.1016/S1473-3099(05)70326-1

DOI: 10.1016/S1473-3099(05)70326-1

CD36 in HIV-related lipodystrophy syndrome: Analysis of CD36 gene polymorphisms in lipodystrophy patients and CD36 receptor expression on peripheral blood mononuclear cells (Conference Paper)

Foster, J. A., Dunn, D., Back, D. J., & Pirmohamed, M. (2006). CD36 in HIV-related lipodystrophy syndrome: Analysis of CD36 gene polymorphisms in lipodystrophy patients and CD36 receptor expression on peripheral blood mononuclear cells. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 86-87). Retrieved from http://gateway.webofknowledge.com/

CTLA-4 and ICOS genes and carbamazepine-induced hypersensitivity (Conference Paper)

Zhang, J. E., Alfirevic, A., Malhotra, R., Park, B. K., & Pirmohamed, M. (2006). CTLA-4 and ICOS genes and carbamazepine-induced hypersensitivity. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 87-88). Retrieved from http://gateway.webofknowledge.com/

Chemical and molecular investigation of hazard associated with drug bioactivation (Conference Paper)

Drummond, N. S., Gardner, I., Jones, R., Wood, T., Naisbitt, D. J., Owen, A., . . . Park, B. K. (2006). Chemical and molecular investigation of hazard associated with drug bioactivation. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 180-181). Retrieved from http://gateway.webofknowledge.com/

Drug Hypersnesitivity Meeting, Liverpool, 2006 (Conference Paper)

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2006). Drug Hypersnesitivity Meeting, Liverpool, 2006. In 2nd International Drug Hypersnesitivity Meeting Vol. 38 (pp. 59). University Press: University Press.

Effect of carbamazepine on the expression of the HSP-70 genes in B cells from hypersensitive patients (Conference Paper)

Alsbou, M., Rice, A., Alfirevic, A., Park, K., & Pirmohamed, M. (2006). Effect of carbamazepine on the expression of the HSP-70 genes in B cells from hypersensitive patients. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 170-171). Retrieved from http://gateway.webofknowledge.com/

Exon resequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance (Journal article)

Leschziner, G. D., Zabaneh, D., Pirmohamed, M., Owen, A., Rogers, J., Coffey, A. J., . . . Johnson, M. R. (2006). Exon resequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance. Pharmacogenetics and Genomics, 16(6), 439-450.

Haplotype structure in abc transporter genes and association of genetic variation in ABCB1, ABCC1, ABCC2, ABCC5, and ABCB4 with epilepsy outcome (Conference Paper)

Leschziner, G. D., Pirmohamed, M., Williamson, P., Marson, A., Middleditch, C., Coffey, A. J., . . . Johnson, M. R. (2006). Haplotype structure in abc transporter genes and association of genetic variation in ABCB1, ABCC1, ABCC2, ABCC5, and ABCB4 with epilepsy outcome. In JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY Vol. 77 (pp. 127). Retrieved from http://gateway.webofknowledge.com/

Identification of IL-6 as a candidate gene in tacrine-induced hepatotoxicity: Association with elevated serum transaminases (Journal article)

Carr, D. F., Alfirevic, A., Sherwood, J., Tugwood, J. D., Park, B. K., & Pirmohamed, M. (2006). Identification of IL-6 as a candidate gene in tacrine-induced hepatotoxicity: Association with elevated serum transaminases. DRUG METABOLISM REVIEWS, 38, 54. Retrieved from http://gateway.webofknowledge.com/

Imatinib and human organic cation transporter 1 (hOCT1): Characterisation of transport in a stably transfected myeloid cell line, and relationship of hOCT1 expression to cytogenetic response (Conference Paper)

Wang, L., Giannoudis, A., Pirmohamed, M., & Clark, R. E. (2006). Imatinib and human organic cation transporter 1 (hOCT1): Characterisation of transport in a stably transfected myeloid cell line, and relationship of hOCT1 expression to cytogenetic response. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 118). Retrieved from http://gateway.webofknowledge.com/

Individual basis of susceptibility to ADRs (Conference Paper)

Pirmohamed, M. (2006). Individual basis of susceptibility to ADRs. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 36). Retrieved from http://gateway.webofknowledge.com/

Metabolism of sulphamethoxazole by dendritic cells: Implications for hypersensitivity (Conference Paper)

Sanderson, J. P., Naisbitt, D. J., Farrell, J., Drummond, N., Mathews, K. L., Pirmohamed, M., . . . Park, B. K. (2006). Metabolism of sulphamethoxazole by dendritic cells: Implications for hypersensitivity. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 182-183). Retrieved from http://gateway.webofknowledge.com/

Multidrug resistance 3 (MDR3) protein and tacrine-induced hepatotoxicity (Conference Paper)

Alfirevic, A., Carr, D. F., Mills, T., Hartkoorn, R., Owen, A., Tugwood, J. D., . . . Pirmohamed, M. (2006). Multidrug resistance 3 (MDR3) protein and tacrine-induced hepatotoxicity. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 173). Retrieved from http://gateway.webofknowledge.com/

Personalised medicine: decades away? (Conference Paper)

Gurwitz, D., Pirmohamed, M., & Lunshof, J. E. (2006). Personalised medicine: decades away?. In JOURNAL OF PHARMACY AND PHARMACOLOGY Vol. 58 (pp. A91). Retrieved from http://gateway.webofknowledge.com/

Pharmacogenetics and Metabolic Disease (Chapter)

Constable, S. A., & Pirmohamed, M. (2006). Pharmacogenetics and Metabolic Disease. In I. P. Hall, & M. Pirmohamed (Eds.), Pharmacogenetics (pp. 245-274). New York: Taylor and Francis.

Pharmacogenetics of Adverse Drug Reactions (Chapter)

Alfirevic, A., Park, B. K., & Pirmohamed, M. (2006). Pharmacogenetics of Adverse Drug Reactions. In I. Hall, & M. Pirmohamed (Eds.), Textbook of Pharmacogenetics (pp. in press). New York: Marcel Dekker.

Pharmacogenomics and herbal medicines (Conference Paper)

Pirmohamed, M. (2006). Pharmacogenomics and herbal medicines. In DRUG SAFETY Vol. 29 (pp. 356). Retrieved from http://gateway.webofknowledge.com/

Polymorphisms in the MHC region and co-trimoxazole hypersensitivity in HIV-positive patients (Conference Paper)

Alsbou, M., Alfirevic, A., Vilar, J., Park, K., & Pirmohamed, M. (2006). Polymorphisms in the MHC region and co-trimoxazole hypersensitivity in HIV-positive patients. In DRUG METABOLISM REVIEWS Vol. 38 (pp. 92). Retrieved from http://gateway.webofknowledge.com/

Single dose atazanavir boosted with ritonavir does not induce insulin resistance in healthy volunteers (Conference Paper)

Doran, D. A., Jones, S. P., Evans, L., Campbell, I. T., Stokes, D. J., Yates, A. P., . . . MacLaren, D. P. M. (2006). Single dose atazanavir boosted with ritonavir does not induce insulin resistance in healthy volunteers. In ANTIVIRAL THERAPY Vol. 11 (pp. L39-L40). Retrieved from http://gateway.webofknowledge.com/

Statins: pharmacology, current uses and widening potential (Journal article)

Constable, S., & Pirmohamed, M. (2006). Statins: pharmacology, current uses and widening potential. www.behindthemedicalheadlines.com. Retrieved from http://www.behindthemedicalheadlines.com/articles/statins.shtml

Textbook of Pharmacogenetics (Book)

Hall, I., & Pirmohamed, M. (Eds.) (2006). Textbook of Pharmacogenetics. New York: Marcel Dekker.

2005

Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudineand zidovudine-containing regimens (Journal article)

Jones, S. P., Qazi, N., Morelese, J., Lebrecht, D., Sutinen, J., Yki-Jarvinen, H., . . . Moyle, G. J. (2005). Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudineand zidovudine-containing regimens. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 40(5), 565-572. doi:10.1097/01.qai.0000187443.30838.3e

DOI: 10.1097/01.qai.0000187443.30838.3e

Haplotype analysis in ABC transporter genes and association of genetic variation in ABCB1, ABCC1, ABCC2, ABCC5 and ABCB4 with epilepsy outcome (Conference Paper)

Leschziner, G., Pirmohamed, M., Middleditch, C., Coffey, A., Bentley, D., & Johnson, M. R. (2005). Haplotype analysis in ABC transporter genes and association of genetic variation in ABCB1, ABCC1, ABCC2, ABCC5 and ABCB4 with epilepsy outcome. In JOURNAL OF THE NEUROLOGICAL SCIENCES Vol. 238 (pp. S131). Retrieved from http://gateway.webofknowledge.com/

Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine and zidovudine containing regimens (Journal article)

Jones, S. P., Qazi, N., Walker, U. A., Moyle, G., Back, D. J., & Pirmohamed, M. (2005). Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine and zidovudine containing regimens. TOXICOLOGY, 213(3), 265-266. Retrieved from http://gateway.webofknowledge.com/

Association between serious carbamazepine hypersensitivity reactions and the HSP70 gene cluster (Journal article)

Alfirevic, A., Mills, T., Harrington, P., Pinel, T., Sherwood, J., Jawaid, A., . . . Pirmohamed, M. (2005). Association between serious carbamazepine hypersensitivity reactions and the HSP70 gene cluster. TOXICOLOGY, 213(3), 264-265. Retrieved from http://gateway.webofknowledge.com/

Effect of nucleoside reverse transcriptase inhibitors and protease inhibitors on TNF-alpha and adiponectin mRNA expression in isolated subcutaneous and omental mature human adipocytes (Journal article)

Jones, S. P., Waitt, C. J., Back, D. J., & Pirmohamed, M. (2005). Effect of nucleoside reverse transcriptase inhibitors and protease inhibitors on TNF-alpha and adiponectin mRNA expression in isolated subcutaneous and omental mature human adipocytes. TOXICOLOGY, 213(3), 266. Retrieved from http://gateway.webofknowledge.com/

The quality of information on monitoring for haematological adverse drug reactions (Journal article)

Ferner, R. E., Coleman, J., Pirmohamed, M., Constable, S. A., & Rouse, A. (2005). The quality of information on monitoring for haematological adverse drug reactions. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 60(4), 448-451. doi:10.1111/j.1365-2125.2005.02440.x

DOI: 10.1111/j.1365-2125.2005.02440.x

The role of metabolic activation in drug-induced hepatotoxicity (Journal article)

Park, B. K., Kitteringham, N. R., Maggs, J. L., Pirmohamed, M., & Williams, D. P. (2005). The role of metabolic activation in drug-induced hepatotoxicity. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 45, 177-202. doi:10.1146/annurev.pharmtox.45.120403.100058

DOI: 10.1146/annurev.pharmtox.45.120403.100058

How do NHS general hospitals in England deal with patients with alcohol-related problems? A questionnaire survey (Journal article)

Owens, L., Gilmore, I. T., & Pirmohamed, M. (2005). How do NHS general hospitals in England deal with patients with alcohol-related problems? A questionnaire survey. ALCOHOL AND ALCOHOLISM, 40(5), 409-412. doi:10.1093/alcalc/agh184

DOI: 10.1093/alcalc/agh184

Investigation of toxic metabolites during drug development. (Journal article)

Park, K., Williams, D. P., Naisbitt, D. J., Kitteringham, N. R., & Pirmohamed, M. (2005). Investigation of toxic metabolites during drug development.. Toxicology and applied pharmacology, 207(2 Suppl), 425-434. doi:10.1016/j.taap.2005.02.029

DOI: 10.1016/j.taap.2005.02.029

Altered adipokine response in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors (Journal article)

Jones, S. P., Janneh, O., Back, D. J., & Pirmohamed, M. (2005). Altered adipokine response in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors. ANTIVIRAL THERAPY, 10(2), 207-213. Retrieved from http://gateway.webofknowledge.com/

Carbamazepine-induced acute liver failure as part of the DRESS syndrome (Journal article)

Syn, W. K., Naisbitt, D. J., Holt, A. P., Pirmohamed, M., & Mutimer, D. J. (2005). Carbamazepine-induced acute liver failure as part of the DRESS syndrome. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 59(8), 988-991. doi:10.1111/j.1368-5031.2005.00550.x

DOI: 10.1111/j.1368-5031.2005.00550.x

Imatinib and hOCT1: Implications for drug resistance and interactions - Reply (Journal article)

Pirmohamed, M., Wang, L. H., & Clark, R. E. (2005). Imatinib and hOCT1: Implications for drug resistance and interactions - Reply. BLOOD, 106(3), 1134. Retrieved from http://gateway.webofknowledge.com/

hOCT 1 and resistance to imatinib (Journal article)

Crossman, L. C., Druker, B. J., & Deininger, M. W. N. (2005). hOCT 1 and resistance to imatinib. BLOOD, 106(3), 1133-1134. doi:10.1182/blood-2005-02-0694

DOI: 10.1182/blood-2005-02-0694

Expression of the imatinib drug transporters hOCT1 and MDR1 levels determines imatinb response and development of BCR-ABL kinase mutations in chronic myeloid leukaemia (CML) (Journal article)

Clark, R. E., Knight, K., Lucas, C. M., Pirmohamed, M., & Wang, L. (2005). Expression of the imatinib drug transporters hOCT1 and MDR1 levels determines imatinb response and development of BCR-ABL kinase mutations in chronic myeloid leukaemia (CML). EXPERIMENTAL HEMATOLOGY, 33(7), 51-52. Retrieved from http://gateway.webofknowledge.com/

Characterization of the T-cell response in a patient with phenindione hypersensitivity (Journal article)

Naisbitt, D. J., Farrell, J., Chamberlain, P. J., Hopkins, J. E., Berry, N. G., Pirmohamed, M., & Park, B. K. (2005). Characterization of the T-cell response in a patient with phenindione hypersensitivity. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 313(3), 1058-1065. doi:10.1124/jpet.105.083758

DOI: 10.1124/jpet.105.083758

Drug-specific lymphocyte proliferation in an HIV-positive patient with nevirapine hepatitis (Journal article)

Drummond, N. S., Vilar, J., Naisbitt, D. J., Hanson, A., Park, B. K., & Pirmohamed, M. (2005). Drug-specific lymphocyte proliferation in an HIV-positive patient with nevirapine hepatitis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(5), 635-636. Retrieved from http://gateway.webofknowledge.com/

Effect of protease inhibitors on LDL receptor and IL-6 expression in lymphocytes and monocytes (Journal article)

Foster, J. A., Williams, D., Dunn, D., Back, D. J., & Pirmohamed, M. (2005). Effect of protease inhibitors on LDL receptor and IL-6 expression in lymphocytes and monocytes. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(5), 629-630. Retrieved from http://gateway.webofknowledge.com/

G-protein beta 3-subunit gene polymorphism and lymphocyte proliferation in carbamazepine hypersensitivity (Journal article)

Alfirevic, A., Naisbitt, D. J., Wu, Y., Farrell, J., Park, B. K., & Pirmohamed, M. (2005). G-protein beta 3-subunit gene polymorphism and lymphocyte proliferation in carbamazepine hypersensitivity. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(5), 645. Retrieved from http://gateway.webofknowledge.com/

Lack of association between serious carbamazepine hypersensitivity reactions and HLA-B in Caucasians (Journal article)

Alfirevic, A., Chadwick, D. W., Park, B. K., & Pirmohamed, M. (2005). Lack of association between serious carbamazepine hypersensitivity reactions and HLA-B in Caucasians. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(5), 641. Retrieved from http://gateway.webofknowledge.com/

Pharmacogenomics and antiviral drugs (Journal article)

Pirmohamed, M. (2005). Pharmacogenomics and antiviral drugs. CLINICA CHIMICA ACTA, 355, S22. Retrieved from http://gateway.webofknowledge.com/

Persistent neurocognitive impairments associated with severe falciparum malaria in Kenyan children (Journal article)

Carter, J. A., Mung'ala-Odera, V., Neville, B. G. R., Murira, G., Mturi, N., Musumba, C., & Newton, C. R. J. C. (2005). Persistent neurocognitive impairments associated with severe falciparum malaria in Kenyan children. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 76(4), 476-481. doi:10.1136/jnnp.2004.043893

DOI: 10.1136/jnnp.2004.043893

Relationship between the C3435T and G(2677)T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver (Journal article)

Owen, A., Goldring, C., Morgan, P., Chadwick, D., Park, B. K., & Pirmohamed, M. (2005). Relationship between the C3435T and G(2677)T(A) polymorphisms in the ABCB1 gene and P-glycoprotein expression in human liver. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 59(3), 365-370. doi:10.1111/j.1365-2125.2005.02229.x

DOI: 10.1111/j.1365-2125.2005.02229.x

Anticipating, investigating and managing the adverse effects of drugs (Journal article)

Pirmohamed, M. (2005). Anticipating, investigating and managing the adverse effects of drugs. CLINICAL MEDICINE, 5(1), 23-26. doi:10.7861/clinmedicine.5-1-23

DOI: 10.7861/clinmedicine.5-1-23

Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine- and zidovudine-containing regimens (Journal article)

Jones, S. P., Qazi, N., Morelese, J., Lebrecht, D., Sutinen, J., Yki-Jarvinen, H., . . . Moyle, G. J. (2005). Assessment of adipokine expression and mitochondrial toxicity in HIV patients with lipoatrophy on stavudine- and zidovudine-containing regimens. Journal of Acquired Immune Deficiency Syndromes, 40, 562-572.

Drug presentation to T cells (Journal article)

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2005). Drug presentation to T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 115(4), 876-877. doi:10.1016/j.jaci.2005.01.011

DOI: 10.1016/j.jaci.2005.01.011

Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes (Conference Paper)

Jones, S. P., Waitt, C., Back, D. J., & Pirmohamed, M. (2005). Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes. In ANTIVIRAL THERAPY Vol. 10 (pp. L21-L22). Retrieved from http://gateway.webofknowledge.com/

Pharmacogenetic origin of adverse drug reactions: A database study of CYP2C9 and CYP2D6-metabolised drugs (Journal article)

Alsbou, M., Dickinson, G. L., Tucker, G. T., Park, B. K., Rostami-Hodjegan, A., & Pirmohamed, M. (2005). Pharmacogenetic origin of adverse drug reactions: A database study of CYP2C9 and CYP2D6-metabolised drugs. DRUG METABOLISM REVIEWS, 37, 26-27. Retrieved from http://gateway.webofknowledge.com/

2004

Active transport of imatinib into and out of cells: implications for drug resistance (Journal article)

Thomas, J., Wang, L. H., Clark, R. E., & Pirmohamed, M. (2004). Active transport of imatinib into and out of cells: implications for drug resistance. BLOOD, 104(12), 3739-3745. doi:10.1182/blood-2003-12-4276

DOI: 10.1182/blood-2003-12-4276

Lipodystrophy in patients with HIV-1 infection: effect of stopping protease inhibitors on TNF-alpha and TNF-receptor levels, and on metabolic parameters (Journal article)

Maher, B., Lloyd, J., Wilkins, E. G. L., Fraser, W. D., Back, D., Park, B. K., & Pirmohamed, M. (2004). Lipodystrophy in patients with HIV-1 infection: effect of stopping protease inhibitors on TNF-alpha and TNF-receptor levels, and on metabolic parameters. ANTIVIRAL THERAPY, 9(6), 879-887. Retrieved from http://gateway.webofknowledge.com/

Mechanisms of insulin resistance in HIV-seronegative individuals acutely treated with ritonavir boosted indinavir and atazanavir regimens (Conference Paper)

Doran, D. A., Jones, S. P., Lagathu, C., Evans, L., Cambell, I. T., Stokes, D. J., . . . Maclaren, D. P. (2004). Mechanisms of insulin resistance in HIV-seronegative individuals acutely treated with ritonavir boosted indinavir and atazanavir regimens. In ANTIVIRAL THERAPY Vol. 9 (pp. L6). Retrieved from http://gateway.webofknowledge.com/

HLA-B*5701 and abacavir hypersensitivity (Journal article)

Watson, M. E., Pimenta, J. M., Spreen, W. R., & Hernandez, J. E. (2004). HLA-B*5701 and abacavir hypersensitivity. PHARMACOGENETICS, 14(11), 783-784. doi:10.1097/00008571-200411000-00011

DOI: 10.1097/00008571-200411000-00011

HLA-B*5701 and abacavir hypersensitivity - Reply (Journal article)

Hughes, D., Park, B. K., & Pirmohamed, M. (2004). HLA-B*5701 and abacavir hypersensitivity - Reply. PHARMACOGENETICS, 14(11), 784. doi:10.1097/00008571-200411000-00012

DOI: 10.1097/00008571-200411000-00012

The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease (Journal article)

Brind, A. M., Hurlstone, A., Edrisinghe, D., Gilmore, I., Fisher, N., Pirmohamed, M., & Fryer, A. A. (2004). The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease. ALCOHOL AND ALCOHOLISM, 39(6), 478-483. doi:10.1093/alcalc/agh105

DOI: 10.1093/alcalc/agh105

Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance (Journal article)

Sharma, R. A., Euden, S. A., Platton, S. L., Cooke, D. N., Shafayat, A., Hewitt, H. R., . . . Steward, W. P. (2004). Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance. CLINICAL CANCER RESEARCH, 10(20), 6847-6854. doi:10.1158/1078-0432.CCR-04-0744

DOI: 10.1158/1078-0432.CCR-04-0744

A method for the rapid depletion of albumin and immunoglobulin from human plasma (Journal article)

Greenough, C., Jenkins, R. E., Kitteringham, N. R., Pirmohamed, M., Park, B. K., & Pennington, S. R. (2004). A method for the rapid depletion of albumin and immunoglobulin from human plasma. PROTEOMICS, 4(10), 3107-3111. doi:10.1002/pmic.200300815

DOI: 10.1002/pmic.200300815

A proteomic investigation into the effect of paracetamol on human plasma proteins (Journal article)

Greenough, C. L., Jenkins, R. E., Kitteringham, N. R., Pirmohamed, M., Pennington, S. R., & Park, B. K. (2004). A proteomic investigation into the effect of paracetamol on human plasma proteins. TOXICOLOGY, 202(1-2), 96-97. Retrieved from http://gateway.webofknowledge.com/

Adverse drug reactions as cause of admission to hospital - Admissions to ear, nose, and throat departments were not mentioned - Reply (Journal article)

Pirmohamed, M., James, S., Meakin, S., & Green, C. (2004). Adverse drug reactions as cause of admission to hospital - Admissions to ear, nose, and throat departments were not mentioned - Reply. BMJ-BRITISH MEDICAL JOURNAL, 329(7463), 460. doi:10.1136/bmj.329.7463.460-a

DOI: 10.1136/bmj.329.7463.460-a

Adverse drug reactions as cause of admission to hospital - Alcohol and other non-prescribed drugs may have impact on adverse drug reactions (Journal article)

Williams, E. R. L., & Taylor, R. E. (2004). Adverse drug reactions as cause of admission to hospital - Alcohol and other non-prescribed drugs may have impact on adverse drug reactions. BRITISH MEDICAL JOURNAL, 329(7463), 459. doi:10.1136/bmj.329.7463.459

DOI: 10.1136/bmj.329.7463.459

Adverse drug reactions as cause of admission to hospital [2] (multiple letters) (Journal article)

Williams, E. R. L., Taylor, R. E., Saunders, D. J., Laws, M. B., Joseph, M., Calder, N. J., . . . Breckenridge, A. M. (2004). Adverse drug reactions as cause of admission to hospital [2] (multiple letters). British Medical Journal, 329(7463), 459-460.

Increased prevalence of epilepsy associated with severe falciparum malaria in children (Journal article)

Carter, J. A., Neville, B. G. R., White, S., Ross, A. J., Otieno, G., Mturi, N., . . . Newton, T. R. J. C. (2004). Increased prevalence of epilepsy associated with severe falciparum malaria in children. EPILEPSIA, 45(8), 978-981. doi:10.1111/j.0013-9580.2004.65103.x

DOI: 10.1111/j.0013-9580.2004.65103.x

Role of the immune system in idiosyncratic drug reactions (Conference Paper)

Pirmohamed, M. (2004). Role of the immune system in idiosyncratic drug reactions. In DRUG METABOLISM REVIEWS Vol. 36 (pp. 29). Retrieved from http://gateway.webofknowledge.com/

Clinical pharmacology - Special safety considerations in drug development and pharmacovigilance (Journal article)

Atuah, K. N., Hughes, D., & Pirmohamed, M. (2004). Clinical pharmacology - Special safety considerations in drug development and pharmacovigilance. DRUG SAFETY, 27(8), 535-554. doi:10.2165/00002018-200427080-00006

DOI: 10.2165/00002018-200427080-00006

Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients (Journal article)

Pirmohamed, M., James, S., Meakin, S., Green, C., Scott, A. K., Walley, T. J., . . . Breckenridge, A. M. (2004). Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients. BMJ-BRITISH MEDICAL JOURNAL, 329(7456), 15-19. doi:10.1136/bmj.329.7456.15

DOI: 10.1136/bmj.329.7456.15

Collecting and sharing information about harms - Appropriate strategies to communicate this information are essential (Journal article)

Pirmohamed, M., & Darbyshire, J. (2004). Collecting and sharing information about harms - Appropriate strategies to communicate this information are essential. BMJ-BRITISH MEDICAL JOURNAL, 329(7456), 6-7. doi:10.1136/bmj.329.7456.6

DOI: 10.1136/bmj.329.7456.6

Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity (Journal article)

Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity. PHARMACOGENETICS, 14(6), 335-342. doi:10.1097/00008571-200406000-00002

DOI: 10.1097/00008571-200406000-00002

Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity. (Journal article)

Hughes, D. A., Vilar, F. J., Ward, C. C., Alfirevic, A., Park, B. K., & Pirmohamed, M. (2004). Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.. Pharmacogenetics, 14(6), 335-342. doi:10.1097/00008571-200406000-00002

DOI: 10.1097/00008571-200406000-00002

Characterization of T-cell responses in phenindione hypersensitivity (Conference Paper)

Naisbitt, D. J., Farrell, J., Chamberlain, P. J., Park, B. K., & Pirmohamed, M. (2004). Characterization of T-cell responses in phenindione hypersensitivity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 675). Retrieved from http://gateway.webofknowledge.com/

Characterization of drug-specific CD4(+) T-cells expressing the skin homing receptor CCR10 in lamotrigine hypersensitivity (Conference Paper)

Farrell, J., Gibney, C. A., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2004). Characterization of drug-specific CD4(+) T-cells expressing the skin homing receptor CCR10 in lamotrigine hypersensitivity. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 690). Retrieved from http://gateway.webofknowledge.com/

Drug-specific proliferation of lymphocytes from patients hypersensitive to carbamazepine and oxcarbazepine: cross-reactivity and possible clinical implications (Conference Paper)

Wu, Y., Farrell, J., Pirmohamed, M., Park, B. K., & Naisbitt, D. J. (2004). Drug-specific proliferation of lymphocytes from patients hypersensitive to carbamazepine and oxcarbazepine: cross-reactivity and possible clinical implications. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 57 (pp. 683). Retrieved from http://gateway.webofknowledge.com/

Drugs and the retina. (Journal article)

Constable, S., & Pirmohamed, M. (2004). Drugs and the retina.. Expert opinion on drug safety, 3(3), 249-259. doi:10.1517/eods.3.3.249.31070

DOI: 10.1517/eods.3.3.249.31070

T-cell recognition of carbamazepine and carbamazepine metabolites (Journal article)

Naisbitt, D. J., Wu, Y., Farrell, J., O'Neill, P. M., Pirmohamed, M., & Park, B. K. (2004). T-cell recognition of carbamazepine and carbamazepine metabolites. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 57(5), 669. Retrieved from http://gateway.webofknowledge.com/

Influx and efflux of imatinib are mediated by active transport via drug transporter proteins (Conference Paper)

Thomas, J., Wang, L., Clark, R. E., & Pirmohamed, M. (2004). Influx and efflux of imatinib are mediated by active transport via drug transporter proteins. In BRITISH JOURNAL OF HAEMATOLOGY Vol. 125 (pp. 39). Retrieved from http://gateway.webofknowledge.com/

Whole-blood cultures from renal-transplant patients stimulated ex vivo show that the effects of cyclosporine on lymphocyte proliferation are related to P-glycoprotein expression (Journal article)

Singh, D., Alexander, J., Owen, A., Rustom, R., Bone, M., Hammad, A., . . . Pirmohamed, M. (2004). Whole-blood cultures from renal-transplant patients stimulated ex vivo show that the effects of cyclosporine on lymphocyte proliferation are related to P-glycoprotein expression. TRANSPLANTATION, 77(4), 557-561. doi:10.1097/01.TP.0000114594.21317.A5

DOI: 10.1097/01.TP.0000114594.21317.A5

The top 100 drug interactions. A Guide to Patient Management. 2003 Edition. (Journal article)

Pirmohamed, M. (2004). The top 100 drug interactions. A Guide to Patient Management. 2003 Edition.. Postgraduate medical journal, 80(940), 123.

Diagnosis of anticonvulsant hypersensitivity syndrome using an in vitro lymphocyte proliferation assay (Conference Paper)

Farrell, J., Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2004). Diagnosis of anticonvulsant hypersensitivity syndrome using an in vitro lymphocyte proliferation assay. In TOXICOLOGY Vol. 194 (pp. 255-256). Retrieved from http://gateway.webofknowledge.com/

Active transport of imatinib into and out of cells: implications for drug resistance (Journal article)

Thomas, J., Wang, L., Clark, R. E., & Pirmohamed, M. (2004). Active transport of imatinib into and out of cells: implications for drug resistance. Blood, 104(12), 3739-3745. doi:10.1182/blood-2003-12-4276

DOI: 10.1182/blood-2003-12-4276

Intravenous therapy (Journal article)

Waitt, C., Waitt, P., & Pirmohamed, M. (2004). Intravenous therapy. POSTGRADUATE MEDICAL JOURNAL, 80(939), 1-6. doi:10.1136/pmj.2003.010421

DOI: 10.1136/pmj.2003.010421

Intravenous therapy. (Journal article)

Waitt, C., Waitt, P., & Pirmohamed, M. (2004). Intravenous therapy.. Postgraduate medical journal, 80(939), 1-6. doi:10.1136/pmj.2003.010421

DOI: 10.1136/pmj.2003.010421

Reply (Journal article)

Hughes, D., Park, B. K., & Pirmohamed, M. (2004). Reply. Pharmacogenetics, 14(11), 784. doi:10.1097/00008571-200411000-00012

DOI: 10.1097/00008571-200411000-00012

2003

Drug point - Possible interaction between warfarin and cranberry juice (Journal article)

Suvarna, R., Pirmohamed, M., & Henderson, L. (2003). Drug point - Possible interaction between warfarin and cranberry juice. BRITISH MEDICAL JOURNAL, 327(7429), 1454. doi:10.1136/bmj.327.7429.1454

DOI: 10.1136/bmj.327.7429.1454

Monitoring drug treatment - Criteria used for screening tests should apply to monitoring (Journal article)

Pirmohamed, M., & Ferner, R. E. (2003). Monitoring drug treatment - Criteria used for screening tests should apply to monitoring. BRITISH MEDICAL JOURNAL, 327(7425), 1179-1181. doi:10.1136/bmj.327.7425.1179

DOI: 10.1136/bmj.327.7425.1179

Monitoring of long-term toxicities of HIV treatments: an international perspective (Journal article)

Bisson, G., Gross, R., Miller, V., Weller, I., Walker, A., & Grp, W. (2003). Monitoring of long-term toxicities of HIV treatments: an international perspective. AIDS, 17(17), 2407-2417. doi:10.1097/00002030-200311210-00002

DOI: 10.1097/00002030-200311210-00002

Active transport of imatinib into and out of cells: Implications for drug resistance. (Conference Paper)

Thomas, J., Wang, L. H., Clark, R. E., & Pirmohamed, M. (2003). Active transport of imatinib into and out of cells: Implications for drug resistance.. In BLOOD Vol. 102 (pp. 859A). Retrieved from http://gateway.webofknowledge.com/

Abacavir hypersensitivity: Is pre-prescription genotyping cost-effective? (Conference Paper)

Hughes, D. A., & Pirmohamed, M. (2003). Abacavir hypersensitivity: Is pre-prescription genotyping cost-effective?. In VALUE IN HEALTH Vol. 6 (pp. 749). doi:10.1016/S1098-3015(10)61908-0

DOI: 10.1016/S1098-3015(10)61908-0

The effects of cyclosporin on lymphocyte proliferation in renal transplant patients: Role of P-glycoprotein (Conference Paper)

Alexander, J. L., Singh, D., Owen, A., Rustom, R., Bone, J. M., Hammad, A., . . . Pirmohamed, M. (2003). The effects of cyclosporin on lymphocyte proliferation in renal transplant patients: Role of P-glycoprotein. In JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY Vol. 14 (pp. 180A). Retrieved from http://gateway.webofknowledge.com/

Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro (Journal article)

Williams, D. P., O'Donnell, C. J. L., Maggs, J. L., Leeder, J. S., Uetrecht, J., Pirmohamed, M., & Park, B. K. (2003). Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro. CHEMICAL RESEARCH IN TOXICOLOGY, 16(10), 1359-1364. doi:10.1021/tx034035z

DOI: 10.1021/tx034035z

Characterisation of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and man (Journal article)

Farrell, J., Naisbitt, D. J., Depta, J. P. H., Pichler, W. J., Pirmohamed, M., & Park, B. K. (2003). Characterisation of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and man. TOXICOLOGY, 192(1), 83-84. Retrieved from http://gateway.webofknowledge.com/

Cytochrome P450 enzyme polymorphisms and adverse drug reactions (Journal article)

Pirmohamed, M., & Park, B. K. (2003). Cytochrome P450 enzyme polymorphisms and adverse drug reactions. TOXICOLOGY, 192(1), 23-32. doi:10.1016/S0300-483X(03)00247-6

DOI: 10.1016/S0300-483X(03)00247-6

Hypersensitivity reactions to lamotrigine: Characterization of drug-specific T-cell clones (Conference Paper)

Naisbitt, D. J., Farrell, J., Wong, G., Dodd, C. C., Hopkins, J. E., Depta, J. P. H., . . . Park, B. K. (2003). Hypersensitivity reactions to lamotrigine: Characterization of drug-specific T-cell clones. In TOXICOLOGY Vol. 192 (pp. 82-83). Retrieved from http://gateway.webofknowledge.com/

Intracellular disposition and metabolic effects of zidovudine, stavudine and four protease inhibitors in cultured adipocytes (Journal article)

Janneh, O., Haggard, P., Tjia, J. F., Jones, S. P., Khoo, S. H., Maher, B., . . . Pirmohamed, M. (2003). Intracellular disposition and metabolic effects of zidovudine, stavudine and four protease inhibitors in cultured adipocytes. ANTIVIRAL THERAPY, 8(5), 417-426. Retrieved from http://gateway.webofknowledge.com/

P450 polymorphisms and adverse drug reactions (Conference Paper)

Pirmohamed, M. (2003). P450 polymorphisms and adverse drug reactions. In TOXICOLOGY Vol. 192 (pp. 55-56). Retrieved from http://gateway.webofknowledge.com/

The BPS web site for Continuing Professional Development in Clinical Pharmacology and Therapeutics (Journal article)

Mucklow, J., Baber, N., Maxwell, S., & Pirmohamed, M. (2003). The BPS web site for Continuing Professional Development in Clinical Pharmacology and Therapeutics. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 56(4), 349-350. doi:10.1046/j.1365-2125.2003.01971.x

DOI: 10.1046/j.1365-2125.2003.01971.x

Herbal medicines (Journal article)

Pirmohamed, M. (2003). Herbal medicines. POSTGRADUATE MEDICAL JOURNAL, 79(935), 489. doi:10.1136/pmj.79.935.489

DOI: 10.1136/pmj.79.935.489

Altered adipocytokine gene ex-pression in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors (Conference Paper)

Jones, S. P., Janneh, O., Back, D. J., & Pirmohamed, M. (2003). Altered adipocytokine gene ex-pression in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors. In ANTIVIRAL THERAPY Vol. 8 (pp. L11-L12). Retrieved from http://gateway.webofknowledge.com/

Heart Failure in Practice. (Journal article)

Pirmohamed, M. (2003). Heart Failure in Practice.. Postgraduate medical journal, 79(934), 487.

Mode of uptake, accumulation and intracellular disposition of zidovudine in cultured 3T3-F442A preadiplocytes (Conference Paper)

Janneh, O., Bray, P. G., Owen, A., Back, D. J., & Pirmohamed, M. (2003). Mode of uptake, accumulation and intracellular disposition of zidovudine in cultured 3T3-F442A preadiplocytes. In ANTIVIRAL THERAPY Vol. 8 (pp. L24-L25). Retrieved from http://gateway.webofknowledge.com/

Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-Cell responses in animals and humans (Journal article)

Farrell, J., Naisbitt, D. J., Drummond, N. S., Depta, J. P. H., Vilar, F. J., Pirmohamed, M., & Park, B. K. (2003). Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-Cell responses in animals and humans. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 306(1), 229-237. doi:10.1124/jpet.103.050112

DOI: 10.1124/jpet.103.050112

The role of polymorphism in manganese superoxide dismutase in susceptibility to alcoholic liver disease (Journal article)

Brind, A., Fryer, A., Hurlstone, A., Fisher, N., & Pirmohamed, M. (2003). The role of polymorphism in manganese superoxide dismutase in susceptibility to alcoholic liver disease. GASTROENTEROLOGY, 124(7), 2000-2002. doi:10.1016/S0016-5085(03)00574-2

DOI: 10.1016/S0016-5085(03)00574-2

Characterization of drug-specific T cells in lamotrigine hypersensitivity (Journal article)

Naisbitt, D. J., Farrell, J., Wong, G., Depta, J. P. H., Dodd, C. C., Hopkins, J. E., . . . Park, B. K. (2003). Characterization of drug-specific T cells in lamotrigine hypersensitivity. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 111(6), 1393-1403. doi:10.1067/mai.2003.1507

DOI: 10.1067/mai.2003.1507

Adverse drug reactions: back to the future (Journal article)

Pirmohamed, M., & Park, B. K. (2003). Adverse drug reactions: back to the future. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 55(5), 486-492. doi:10.1046/j.1365-2125.2003.01847.x

DOI: 10.1046/j.1365-2125.2003.01847.x

Reporting of adverse drug reactions by nurses (Journal article)

Morrison-Griffiths, S., Walley, T. J., Park, B. K., Breckenridge, A. M., & Pirmohamed, M. (2003). Reporting of adverse drug reactions by nurses. LANCET, 361(9366), 1347-1348. doi:10.1016/S0140-6736(03)13043-7

DOI: 10.1016/S0140-6736(03)13043-7

Abacavir hypersensitivity in human immunodeficiency virus-positive patients: demonstration of the presence of drug-specific lymphocyte proliferation in vitro (Conference Paper)

Dodd, C. C., Naisbitt, D. J., Vilar, F. J., Gordon, S. F., Maggs, J. L., Park, B. K., & Pirmohamed, M. (2003). Abacavir hypersensitivity in human immunodeficiency virus-positive patients: demonstration of the presence of drug-specific lymphocyte proliferation in vitro. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 55 (pp. 421). Retrieved from http://gateway.webofknowledge.com/

Erratum (Journal article)

Erratum (2003). British Journal of Clinical Pharmacology, 55(4), 417. doi:10.1046/j.1365-2125.2003.01815.x

DOI: 10.1046/j.1365-2125.2003.01815.x

NF kappa B in human neutrophils: relationship between apoptosis and glutathione concentrations (Conference Paper)

Hanrahan, N. J., O'Donnell, C., Williams, D. P., Pirmohamed, M., & Park, B. K. (2003). NF kappa B in human neutrophils: relationship between apoptosis and glutathione concentrations. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 55 (pp. 441). Retrieved from http://gateway.webofknowledge.com/

Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity (vol 55, pg 158, 2002) (Journal article)

Alfirevic, A., Stalford, A. C., Vilar, F. J., Wilkins, E. G. L., Park, B. K., & Pirmohamed, M. (2003). Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity (vol 55, pg 158, 2002). BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 55(4), 417. Retrieved from http://gateway.webofknowledge.com/

Transcription factor regulation and gene expression in response to the antipsychotic, clozapine (Journal article)

Williams, D. P., O'Donnell, C., Randle, L. E., Goldring, C. E. P., Garcia-Allen, C., Johnston, G., . . . Park, B. K. (2003). Transcription factor regulation and gene expression in response to the antipsychotic, clozapine. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 55(4), 446. Retrieved from http://gateway.webofknowledge.com/

Characterization of lamotrigine-specific T cells from hypersensitive patients. (Conference Paper)

Naisbitt, D. J., Farrell, J., Hopkins, J. E., Wong, G., Pichler, W. J., Pirmohamed, M., & Park, K. (2003). Characterization of lamotrigine-specific T cells from hypersensitive patients.. In TOXICOLOGICAL SCIENCES Vol. 72 (pp. 52). Retrieved from http://gateway.webofknowledge.com/

Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones (Journal article)

Naisbitt, D. J., Britschgi, M., Wong, G., Farrell, J., Depta, J. P. H., Chadwick, D. W., . . . Park, B. K. (2003). Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drug-specific T cell clones. MOLECULAR PHARMACOLOGY, 63(3), 732-741. doi:10.1124/mol.63.3.732

DOI: 10.1124/mol.63.3.732

Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity (Journal article)

Alfirevic, A., Stalford, A. C., Vilar, F. J., Wilkins, E. G. L., Park, B. K., & Pirmohamed, M. (2003). Slow acetylator phenotype and genotype in HIV-positive patients with sulphamethoxazole hypersensitivity. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 55(2), 158-165. doi:10.1046/j.1365-2125.2003.01754.x

DOI: 10.1046/j.1365-2125.2003.01754.x

Cerebral malaria - Optimising management (Journal article)

Mturi, N., Musumba, C. O., Wamola, B. M., Ogutu, B. R., & Newton, C. R. J. C. (2003). Cerebral malaria - Optimising management. CNS DRUGS, 17(3), 153-165. doi:10.2165/00023210-200317030-00002

DOI: 10.2165/00023210-200317030-00002

Drug-induced apoptosis: Clinical significance (Conference Paper)

Pirmohamed, M. (2003). Drug-induced apoptosis: Clinical significance. In DRUG METABOLISM REVIEWS Vol. 35 (pp. 24). Retrieved from http://gateway.webofknowledge.com/

Immunopharmacology of hypersensitivity reactions to drugs (Journal article)

Naisbitt, D. J., Pirmohamed, M., & Park, B. K. (2003). Immunopharmacology of hypersensitivity reactions to drugs. CURRENT ALLERGY AND ASTHMA REPORTS, 3(1), 22-29. doi:10.1007/s11882-003-0006-9

DOI: 10.1007/s11882-003-0006-9

Intracellular disposition and metabolic effects of zidovudine, stavudine and four protease inhibitors in cultured adipocytes (Journal article)

Janneh, O., Hoggard, P. G., Tjia, J. F., Jones, S. P., Khoo, S. H., Maher, B., . . . Pirmohamed, M. (2003). Intracellular disposition and metabolic effects of zidovudine, stavudine and four protease inhibitors in cultured adipocytes. Antivir Ther, 8(5), 417-426. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/14640389

Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system. (Journal article)

Vilar, F. J., Naisbitt, D. J., Park, B. K., & Pirmohamed, M. (2003). Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system.. Journal of HIV therapy, 8(2), 42-47.

2002

The danger hypothesis - potential role in idiosyncratic drug reactions (Journal article)

Pirmohamed, M., Naisbitt, D. J., Gordon, F., & Park, B. K. (2002). The danger hypothesis - potential role in idiosyncratic drug reactions. TOXICOLOGY, 181, 55-63. doi:10.1016/S0300-483X(02)00255-X

DOI: 10.1016/S0300-483X(02)00255-X

TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy (Journal article)

Maher, B., Alfirevic, A., Vilar, F. J., Wilkins, E. G. L., Park, B. K., & Pirmohamed, M. (2002). TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy. AIDS, 16(15), 2013-2018. doi:10.1097/00002030-200210180-00005

DOI: 10.1097/00002030-200210180-00005

Altered TNF-alpha and IL-6 levels and the antiadipogenic effects of antiretrovirals on cultured adipocytes: possible mechanisms for their role in lipodystrophy in HIV-infected patients (Conference Paper)

Jones, S. P., Janneh, O., Maher, B., Khoo, S., Back, D. J., & Pirmohamed, M. (2002). Altered TNF-alpha and IL-6 levels and the antiadipogenic effects of antiretrovirals on cultured adipocytes: possible mechanisms for their role in lipodystrophy in HIV-infected patients. In ANTIVIRAL THERAPY Vol. 7 (pp. L2). Retrieved from http://gateway.webofknowledge.com/

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation (Journal article)

Naisbitt, D. J., Farrell, J., Gordon, S. F., Maggs, J. L., Burkhart, C., Pichler, W. J., . . . Park, B. K. (2002). Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation. MOLECULAR PHARMACOLOGY, 62(3), 628-637. doi:10.1124/mol.62.3.628

DOI: 10.1124/mol.62.3.628

Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases (Journal article)

Ilett, K. F., Ethell, B. T., Maggs, J. L., Davis, T. M. E., Batty, K. T., Burchell, B., . . . Edwards, G. (2002). Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases. DRUG METABOLISM AND DISPOSITION, 30(9), 1005-1012. doi:10.1124/dmd.30.9.1005

DOI: 10.1124/dmd.30.9.1005

Intracellular disposition of zidovudine, stavudine and protease inhibitors and their metabolic effects in cultured adipocytes (Conference Paper)

Janneh, O., Hoggard, P. G., Sales, S. D., Jones, S. P., Tjia, J. F., Khoo, S. H., . . . Pirmohamed, M. (2002). Intracellular disposition of zidovudine, stavudine and protease inhibitors and their metabolic effects in cultured adipocytes. In ANTIVIRAL THERAPY Vol. 7 (pp. L1-L2). Retrieved from http://gateway.webofknowledge.com/

Prospective survey for the burden of alcohol-related admissions to an inner-city intensive care unit (Conference Paper)

Owens, L., Pirmohamed, M., & Mostafa, S. (2002). Prospective survey for the burden of alcohol-related admissions to an inner-city intensive care unit. In INTENSIVE CARE MEDICINE Vol. 28 (pp. S160). Retrieved from http://gateway.webofknowledge.com/

Are chemically reactive metabolites responsible for adverse reactions to drugs? (Journal article)

Williams, D. P., Kitteringham, N. R., Naisbitt, D. J., Pirmohamed, M., Smith, D. A., & Park, B. K. (2002). Are chemically reactive metabolites responsible for adverse reactions to drugs?. Current drug metabolism, 3(4), 351-366. doi:10.2174/1389200023337423

DOI: 10.2174/1389200023337423

Best evidence and the clinical decision making process (Journal article)

Pirmohamed, M. (2002). Best evidence and the clinical decision making process. POSTGRADUATE MEDICAL JOURNAL, 78(919), 316. doi:10.1136/pmj.78.919.316

DOI: 10.1136/pmj.78.919.316

Absence of correlation between C3435T polymorphism in the MDRI gene and expression of P-glycoprotein in human liver (Conference Paper)

Owen, A., Goldring, C., Morgan, P., Park, B. K., & Pirmohamed, M. (2002). Absence of correlation between C3435T polymorphism in the MDRI gene and expression of P-glycoprotein in human liver. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 420P). Retrieved from http://gateway.webofknowledge.com/

Anticonvulsant hypersensitivity syndrome: Methodology to investigate the role of metabolism and processing of carbamazepine to T-cells (Conference Paper)

Naisbitt, D. J., Depta, J., Wong, G., Farrell, J., Chadwick, D. W., Pichler, W. J., . . . Park, B. K. (2002). Anticonvulsant hypersensitivity syndrome: Methodology to investigate the role of metabolism and processing of carbamazepine to T-cells. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 443P). Retrieved from http://gateway.webofknowledge.com/

Anticonvulsant hypersensitivity syndrome: characterization of the phenotype and cytokine profile of carabamazepine-specific T-cell clones (Conference Paper)

Naisbitt, D. J., Britschgi, M., Wong, G., Farrell, J., Chadwick, D. W., Pichler, W. J., . . . Park, B. K. (2002). Anticonvulsant hypersensitivity syndrome: characterization of the phenotype and cytokine profile of carabamazepine-specific T-cell clones. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 418P-419P). Retrieved from http://gateway.webofknowledge.com/

Clozapine metabolism and redox regulation of transcription factors in human neutrophils (Conference Paper)

O'Donnell, C., Williams, D. P., Pirmohamed, M., Uetrecht, J. P., & Park, B. K. (2002). Clozapine metabolism and redox regulation of transcription factors in human neutrophils. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 419P-420P). Retrieved from http://gateway.webofknowledge.com/

MHC-restricted and processing dependent presentation of drug metabolite-modified cellular proteins to T-cells in the rat (Conference Paper)

Farrell, J., Gordon, S. F., Naisbitt, D. J., Gallimore, A., Burkhart, C., Pichler, W. J., . . . Park, B. K. (2002). MHC-restricted and processing dependent presentation of drug metabolite-modified cellular proteins to T-cells in the rat. In BRITISH JOURNAL OF CLINICAL PHARMACOLOGY Vol. 53 (pp. 442P). Retrieved from http://gateway.webofknowledge.com/

Anticonvulsant agents (Chapter)

Leeder, J. S., & Pirmohamed, M. (2002). Anticonvulsant agents. In Drug-Induced Liver Disease (pp. 425-447).

Are chemically reactive metabolites responsible for adverse reactions to drugs? (Journal article)

Pre-registration nurse education in pharmacology: is it adequate for the roles that nurses are expected to fulfil? (Journal article)

Morrison-Griffiths, S., Snowden, M. A., & Pirmohamed, M. (2002). Pre-registration nurse education in pharmacology: is it adequate for the roles that nurses are expected to fulfil?. NURSE EDUCATION TODAY, 22(6), 447-456. doi:10.1054/nedt.2002.0756

DOI: 10.1054/nedt.2002.0756

TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy (Journal article)

Maher, B., Alfirevic, A., Vilar, F. J., Wilkins, E. G., Park, B. K., & Pirmohamed, M. (2002). TNF-alpha promoter region gene polymorphisms in HIV-positive patients with lipodystrophy. AIDS, 16(15), 2013-2018. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/12370499

2001

Polymorphisms in the TNF-alpha and TNF-receptor genes in patients with coronary artery disease (Journal article)

Allen, R. A., Lee, E. M., Roberts, D. H., Park, B. K., & Pirmohamed, M. (2001). Polymorphisms in the TNF-alpha and TNF-receptor genes in patients with coronary artery disease. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 31(10), 843-851. doi:10.1046/j.1365-2362.2001.00907.x

DOI: 10.1046/j.1365-2362.2001.00907.x

Clozapine undergoes organ-specific bioactivation and protein binding: Toxicological implications (Conference Paper)

O'Donnell, C., Williams, D., Pirmohamed, M., & Park, B. K. (2001). Clozapine undergoes organ-specific bioactivation and protein binding: Toxicological implications. In TOXICOLOGY Vol. 168 (pp. 132-133). Retrieved from http://gateway.webofknowledge.com/

Short-term exercise training improves body composition and hyperlipidaemia in HIV-positive individuals with lipodystrophy (Journal article)

Jones, S. P., Doran, D. A., Leat, P. B., Maher, B., & Pirmohamed, M. (2001). Short-term exercise training improves body composition and hyperlipidaemia in HIV-positive individuals with lipodystrophy. AIDS, 15(15), 2049-2051. doi:10.1097/00002030-200110190-00021

DOI: 10.1097/00002030-200110190-00021

Pharmacogenetics and pharmacogenomics (Journal article)

Pirmohamed, M. (2001). Pharmacogenetics and pharmacogenomics. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 52(4), 345-347. doi:10.1046/j.0306-5251.2001.01498.x

DOI: 10.1046/j.0306-5251.2001.01498.x

The burden of alcohol on an inner-city intensive care unit in the UK (Journal article)

Owens, L., Mostafa, S. M., Gilmore, I. T., Murthy, B. V., & Pirmohamed, M. (2001). The burden of alcohol on an inner-city intensive care unit in the UK. INTENSIVE CARE MEDICINE, 27, S153. Retrieved from http://gateway.webofknowledge.com/

LC determination of carbamazepine in murine brain (Journal article)

Owen, A., Tettey, J. N., Morgan, P., Pirmohamed, M., & Park, B. K. (2001). LC determination of carbamazepine in murine brain. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 26(4), 573-577. doi:10.1016/S0731-7085(01)00477-0

DOI: 10.1016/S0731-7085(01)00477-0

Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo (Journal article)

Tettey, J. N., Maggs, J. L., Rapeport, W. G., Pirmohamed, M., & Park, B. K. (2001). Enzyme-induction dependent bioactivation of troglitazone and troglitazone quinone in vivo. CHEMICAL RESEARCH IN TOXICOLOGY, 14(8), 965-974. doi:10.1021/tx0001981

DOI: 10.1021/tx0001981

Genetic determinants of dose optimisation: molecular biology in the prevention of drug toxicity (Conference Paper)

Pirmohamed, M., & Park, B. K. (2001). Genetic determinants of dose optimisation: molecular biology in the prevention of drug toxicity. In OPTIMAL DOSE IDENTIFICATION Vol. 1220 (pp. 187-202). doi:10.1016/S0531-5131(01)00297-7

DOI: 10.1016/S0531-5131(01)00297-7

HIV and drug allergy (Journal article)

Pirmohamed, M., & Park, B. K. (2001). HIV and drug allergy. Current Opinion in Allergy and Clinical Immunology, 1(4), 311-316. doi:10.1097/01.all.0000011032.69243.10

DOI: 10.1097/01.all.0000011032.69243.10

Optimal dose identification: Predicting a safe dose in man from animal studies (Conference Paper)

Park, B. K., Kitteringham, N. R., Maggs, J. L., Boocock, D., White, I., Elsby, R., & Pirmohamed, M. (2001). Optimal dose identification: Predicting a safe dose in man from animal studies. In OPTIMAL DOSE IDENTIFICATION Vol. 1220 (pp. 13-25). doi:10.1016/S0531-5131(01)00283-7

DOI: 10.1016/S0531-5131(01)00283-7

Reactive metabolites and their role in drug reactions (Journal article)

Naisbitt, D. J., Williams, D. P., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (2001). Reactive metabolites and their role in drug reactions. Current Opinion in Allergy and Clinical Immunology, 1(4), 317-325. doi:10.1097/01.all.0000011033.64625.5a

DOI: 10.1097/01.all.0000011033.64625.5a

Drug metabolism and drug toxicity (Journal article)

Park, B. K., Kitteringham, N. R., Kenny, J. R., & Pirmohamed, M. (2001). Drug metabolism and drug toxicity. InflammoPharmacology, 9(1-2), 183-199. doi:10.1163/156856001300248461

DOI: 10.1163/156856001300248461

The danger hypothesis: inflammation and idiosyncratic toxicity (Conference Paper)

Pirmohamed, M., Naisbitt, D. J., & Park, B. K. (2001). The danger hypothesis: inflammation and idiosyncratic toxicity. In TOXICOLOGY Vol. 164 (pp. 5). Retrieved from http://gateway.webofknowledge.com/

Elevated pyrimidopurinone-deoxyguanosine adducts in adenomas of Apc(Min) mice and suppression by dietary curcumin (Conference Paper)

Sharma, R. A., Perkins, S., Singh, R., Steward, W. P., & Gescher, A. (2001). Elevated pyrimidopurinone-deoxyguanosine adducts in adenomas of Apc(Min) mice and suppression by dietary curcumin. In BRITISH JOURNAL OF CANCER Vol. 85 (pp. 40). Retrieved from http://gateway.webofknowledge.com/

Pilot study of Curcuma extract in patients: Safety and biological activity (Conference Paper)

Sharma, R. A., McLelland, H. R., Ireson, C. R., Jones, D. J. L., Hill, K. A., Euden, S. A., . . . Steward, W. P. (2001). Pilot study of Curcuma extract in patients: Safety and biological activity. In BRITISH JOURNAL OF CANCER Vol. 85 (pp. 40). Retrieved from http://gateway.webofknowledge.com/

Genetic susceptibility to adverse drug reactions (Journal article)

Pirmohamed, M., & Park, B. K. (2001). Genetic susceptibility to adverse drug reactions. TRENDS IN PHARMACOLOGICAL SCIENCES, 22(6), 298-305. doi:10.1016/S0165-6147(00)01717-X

DOI: 10.1016/S0165-6147(00)01717-X

Carbamazepine is not a substrate for P-glycoprotein (Journal article)

Owen, A., Pirmohamed, M., Tettey, J. N., Morgan, P., Chadwick, D., & Park, B. K. (2001). Carbamazepine is not a substrate for P-glycoprotein. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 51(4), 345-349. doi:10.1046/j.1365-2125.2001.01359.x

DOI: 10.1046/j.1365-2125.2001.01359.x

TNF alpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients (Journal article)

Pirmohamed, M., Lin, K., Chadwick, D., & Park, B. K. (2001). TNF alpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients. NEUROLOGY, 56(7), 890-896. doi:10.1212/WNL.56.7.890

DOI: 10.1212/WNL.56.7.890

TNFa promoter region gene polymorphisms in carbamazepine-hypersensitive patients (Journal article)

Pirmohamed, M., Lin, K., Chadwick, D., & Park, B. K. (2001). TNFa promoter region gene polymorphisms in carbamazepine-hypersensitive patients. Neurology, 56(7), 890-896. doi:10.1212/WNL.56.7.890

DOI: 10.1212/WNL.56.7.890

Interleukin-10 promoter region polymorphisms and alcoholic liver disease (Conference Paper)

Newberry, H., Edirisinghe, D., Fisher, N., Gilmore, I. T., Adams, D., Park, B. K., & Pirmohamed, M. (2001). Interleukin-10 promoter region polymorphisms and alcoholic liver disease. In GASTROENTEROLOGY Vol. 120 (pp. A543). Retrieved from http://gateway.webofknowledge.com/

TNF-alpha promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis (Conference Paper)

Ahdulrazeg, E. S. M., Alfirevic, A., Gilmore, I. T., Sutton, R., Greenhalf, W., Neoptolemas, J., . . . Pirmohamed, M. (2001). TNF-alpha promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis. In GASTROENTEROLOGY Vol. 120 (pp. A32-A33). Retrieved from http://gateway.webofknowledge.com/

Toxicogenetics in drug development (Journal article)

Park, B. K., & Pirmohamed, M. (2001). Toxicogenetics in drug development. TOXICOLOGY LETTERS, 120(1-3), 281-291. doi:10.1016/S0378-4274(01)00280-6

DOI: 10.1016/S0378-4274(01)00280-6

Attitudes and knowledge of hospital pharmacists to adverse drug reaction reporting (Journal article)

Green, C. F., Mottram, D. R., Rowe, P. H., & Pirmohamed, M. (2001). Attitudes and knowledge of hospital pharmacists to adverse drug reaction reporting. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 51(1), 81-86. doi:10.1046/j.1365-2125.2001.01306.x

DOI: 10.1046/j.1365-2125.2001.01306.x

Metabolic activation in drug allergies (Journal article)

Park, B. K., Naisbitt, D. J., Gordon, S. F., Kitteringham, N. R., & Pirmohamed, M. (2001). Metabolic activation in drug allergies. TOXICOLOGY, 158(1-2), 11-23. doi:10.1016/S0300-483X(00)00397-8

DOI: 10.1016/S0300-483X(00)00397-8

Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo (Journal article)

Naisbitt, D. J., Gordon, S. F., Pirmohamed, M., Burkhart, C., Cribb, A. E., Pichler, W. J., & Park, B. K. (2001). Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo. BRITISH JOURNAL OF PHARMACOLOGY, 133(2), 295-305. doi:10.1038/sj.bjp.0704074

DOI: 10.1038/sj.bjp.0704074

HIV and drug allergy (Journal article)

Pirmohamed, M., & Park, B. K. (2001). HIV and drug allergy. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 1(4), 311-316. doi:10.1097/00130832-200108000-00006

DOI: 10.1097/00130832-200108000-00006

Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer (Journal article)

Sharma, R. A., McLelland, H. R., Hill, K. A., Ireson, C. R., Euden, S. A., Manson, M. M., . . . Steward, W. P. (2001). Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. CLINICAL CANCER RESEARCH, 7(7), 1894-1900. Retrieved from http://gateway.webofknowledge.com/

Reactive metabolites and their role in drug reactions (Journal article)

Naisbitt, D. J., Williams, D. P., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (2001). Reactive metabolites and their role in drug reactions. CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, 1(4), 317-325. Retrieved from http://gateway.webofknowledge.com/

TNF-alpha promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis (Other)

Ahdulrazeg, E. S. M., Alfirevic, A., Gilmore, I. T., Sutton, R., Greenhalf, W., Neoptolemas, J., . . . Pirmohamed, M. (2001). TNF-alpha promoter region gene polymorphisms in patients with alcohol-induced chronic pancreatitis. In Gastroenterology (Vol. 120, Iss. 5, pp. 167). [Paper].

The pharmacogenomics of HIV therapy. (Journal article)

Pirmohamed, M., & Back, D. J. (2001). The pharmacogenomics of HIV therapy.. The pharmacogenomics journal, 1(4), 243-253. doi:10.1038/sj.tpj.6500069

DOI: 10.1038/sj.tpj.6500069

2000

Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity (Journal article)

Pirmohamed, M., Alfirevic, A., Vilar, J., Stalford, A., Wilkins, E. G. L., Sim, E., & Park, B. K. (2000). Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity. PHARMACOGENETICS, 10(8), 705-713. doi:10.1097/00008571-200011000-00005

DOI: 10.1097/00008571-200011000-00005

Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection (Journal article)

Naisbitt, D. J., Vilar, F. J., Stalford, A. C., Wilkins, E. G. L., Pirmohamed, M., & Park, B. K. (2000). Plasma cysteine deficiency and decreased reduction of nitrososulfamethoxazole with HIV infection. AIDS RESEARCH AND HUMAN RETROVIRUSES, 16(18), 1929-1938. doi:10.1089/088922200750054657

DOI: 10.1089/088922200750054657

Adverse drug reactions as a cause of admission to an acute medical assessment unit: a pilot study (Journal article)

Green, C. F., Mottram, D. R., Rowe, P. H., & Pirmohamed, M. (2000). Adverse drug reactions as a cause of admission to an acute medical assessment unit: a pilot study. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 25(5), 355-361. doi:10.1046/j.1365-2710.2000.00298.x

DOI: 10.1046/j.1365-2710.2000.00298.x

Advances in molecular toxicology-towards understanding idiosyncratic drug toxicity (Journal article)

Park, B. K., Kitteringham, N. R., Powell, H., & Pirmohamed, M. (2000). Advances in molecular toxicology-towards understanding idiosyncratic drug toxicity. TOXICOLOGY, 153(1-3), 39-60. doi:10.1016/S0300-483X(00)00303-6

DOI: 10.1016/S0300-483X(00)00303-6

Metabolism of lamotrigine to a reactive arene oxide intermediate (Journal article)

Maggs, J. L., Naisbitt, D. J., Tettey, J. N. A., Pirmohamed, M., & Park, B. K. (2000). Metabolism of lamotrigine to a reactive arene oxide intermediate. CHEMICAL RESEARCH IN TOXICOLOGY, 13(11), 1075-1081. doi:10.1021/tx0000825

DOI: 10.1021/tx0000825

Clinicians' attitudes to reporting adverse drug reactions (Conference Paper)

Tyrer, F., Breckenridge, A., Pirmohamed, M., Babiker, A., Hooker, M., Swart, A. M., . . . Darbyshire, J. (2000). Clinicians' attitudes to reporting adverse drug reactions. In AIDS Vol. 14 (pp. S65). Retrieved from http://gateway.webofknowledge.com/

Decreased activity of the enzyme CYP2C9 does not protect against sulphonamide hypersensitivity in HIV positive patients (Conference Paper)

Stalford, A. C., Vilar, F. J., Alfirevic, A., Wilkins, E. G. L., Pirmohamed, M., & Park, B. K. (2000). Decreased activity of the enzyme CYP2C9 does not protect against sulphonamide hypersensitivity in HIV positive patients. In AIDS Vol. 14 (pp. S97). Retrieved from http://gateway.webofknowledge.com/

Lipodystrophy in patients with HIV-1 infection: effect of stopping protease inhibitors on TNF-receptor levels, insulin resistance, and lipid profile (Conference Paper)

Maher, B., Lloyd, J., Wilkins, E. G. L., Fraser, W. D., Back, D. J., Park, B. K., & Pirmohamed, M. (2000). Lipodystrophy in patients with HIV-1 infection: effect of stopping protease inhibitors on TNF-receptor levels, insulin resistance, and lipid profile. In AIDS Vol. 14 (pp. S56). Retrieved from http://gateway.webofknowledge.com/

Commentary - bisphosphonates and calcium homoeostasis (Journal article)

Pirmohamed, M. (2000). Commentary - bisphosphonates and calcium homoeostasis. POSTGRADUATE MEDICAL JOURNAL, 76(897), 418-419. doi:10.1136/pmj.76.897.418

DOI: 10.1136/pmj.76.897.418

Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine (Journal article)

Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Uetrecht, J. P., & Park, B. K. (2000). Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine. MOLECULAR PHARMACOLOGY, 58(1), 207-216. doi:10.1124/mol.58.1.207

DOI: 10.1124/mol.58.1.207

Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4(+) T cells from allergic individuals (Journal article)

Schnyder, B., Burkhart, C., Schnyder-Frutig, K., von Greyerz, S., Naisbitt, D. J., Pirmohamed, M., . . . Pichler, W. J. (2000). Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4(+) T cells from allergic individuals. JOURNAL OF IMMUNOLOGY, 164(12), 6647-6654. doi:10.4049/jimmunol.164.12.6647

DOI: 10.4049/jimmunol.164.12.6647

General practice nurses' knowledge of alcohol use and misuse: A questionnaire survey (Journal article)

Owens, L., Gilmore, I. T., & Pirmohamed, M. (2000). General practice nurses' knowledge of alcohol use and misuse: A questionnaire survey. ALCOHOL AND ALCOHOLISM, 35(3), 259-262. doi:10.1093/alcalc/35.3.259

DOI: 10.1093/alcalc/35.3.259

Alcohol abuse and the burden on the NHS - time for action (Journal article)

Pirmohamed, M., & Gilmore, I. T. (2000). Alcohol abuse and the burden on the NHS - time for action. JOURNAL OF THE ROYAL COLLEGE OF PHYSICIANS OF LONDON, 34(2), 161-162. Retrieved from http://gateway.webofknowledge.com/

A simple sore throat? (Journal article)

Maher, B., Carey, P., & Pirmohamed, M. (2000). A simple sore throat?. HOSPITAL MEDICINE, 61(6), 435. doi:10.12968/hosp.2000.61.6.1364

DOI: 10.12968/hosp.2000.61.6.1364

Hepatocellular response to chemical stress in CD-1 mice: Induction of early genes and gamma-glutamylcysteine synthetase (Journal article)

Kitteringham, N. R., Powell, H., Clement, Y. N., Dodd, C. C., Tettey, J. N. A., Pirmohamed, M., . . . Park, B. K. (2000). Hepatocellular response to chemical stress in CD-1 mice: Induction of early genes and gamma-glutamylcysteine synthetase. HEPATOLOGY, 32(2), 321-333. doi:10.1053/jhep.2000.9602

DOI: 10.1053/jhep.2000.9602

Immunological principles of adverse drug reactions - The initiation and propagation of immune responses elicited by drug treatment (Journal article)

Naisbitt, D. J., Gordon, S. F., Pirmohamed, M., & Park, B. K. (2000). Immunological principles of adverse drug reactions - The initiation and propagation of immune responses elicited by drug treatment. DRUG SAFETY, 23(6), 483-507. doi:10.2165/00002018-200023060-00002

DOI: 10.2165/00002018-200023060-00002

Is carbamezapine a substrate for P-glycoprotein? (Conference Paper)

Owen, A., Pirmohamed, M., Tettey, J., Morgan, P., Chadwick, D., & Park, B. K. (2000). Is carbamezapine a substrate for P-glycoprotein?. In British Journal of Clinical Pharmacology Vol. 50 (pp. 387).

Specialist nurse reporting of adverse drug reactions. (Journal article)

Morrison-Griffiths, S., & Pirmohamed, M. (2000). Specialist nurse reporting of adverse drug reactions.. Professional nurse (London, England), 15(5), 300-304.

The burden of alcohol misuse on an inner-city general hospital (Journal article)

Pirmohamed, M., Brown, C., Owens, L., Luke, C., Gilmore, I. T., Breckenridge, A. M., & Park, B. K. (2000). The burden of alcohol misuse on an inner-city general hospital. QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS, 93(5), 291-295. doi:10.1093/qjmed/93.5.291

DOI: 10.1093/qjmed/93.5.291

1999

Adverse drug reaction of the month - Haemolytic anaemia associated with indinavir (Journal article)

Morrison-Griffiths, S., Newman, M., O'Mahony, C., & Pirmohamed, M. (1999). Adverse drug reaction of the month - Haemolytic anaemia associated with indinavir. POSTGRADUATE MEDICAL JOURNAL, 75(883), 313-315. doi:10.1136/pgmj.75.883.313

DOI: 10.1136/pgmj.75.883.313

Haemolytic anaemia associated with indinavir. (Journal article)

Morrison-Griffiths, S., Newman, M., O'Mahony, C., & Pirmohamed, M. (1999). Haemolytic anaemia associated with indinavir.. Postgraduate medical journal, 75(883), 313-315. doi:10.1136/pgmj.75.883.313

DOI: 10.1136/pgmj.75.883.313

Adverse drug reactions: role of enzyme inhibition and induction (Conference Paper)

Pirmohamed, M., & Park, B. K. (1999). Adverse drug reactions: role of enzyme inhibition and induction. In VARIABILITY IN HUMAN DRUG RESPONSE Vol. 8 (pp. 41-53). Retrieved from http://gateway.webofknowledge.com/

Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity (Journal article)

Naisbitt, D. J., Hough, S. J., Gill, H. J., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (1999). Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity. BRITISH JOURNAL OF PHARMACOLOGY, 126(6), 1393-1407. doi:10.1038/sj.bjp.0702453

DOI: 10.1038/sj.bjp.0702453

Communication regarding adverse drug reactions between secondary and primary care: a postal questionnaire survey of general practitioners (Journal article)

Green, C. F., Mottram, D. R., Pirmohamed, M., Horner, R., & Rowe, P. H. (1999). Communication regarding adverse drug reactions between secondary and primary care: a postal questionnaire survey of general practitioners. JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 24(2), 133-139. doi:10.1046/j.1365-2710.1999.00210.x

DOI: 10.1046/j.1365-2710.1999.00210.x

The adverse effects of drugs (Journal article)

Pirmohamed, M., & Park, B. K. (1999). The adverse effects of drugs. HOSPITAL MEDICINE, 60(5), 348-352. doi:10.12968/hosp.1999.60.5.1114

DOI: 10.12968/hosp.1999.60.5.1114

The effect of genetic polymorphisms in CYP2C9 on sulphamethoxazole N-hydroxylation (Journal article)

Gill, H. J., Tjia, J. F., Kitteringham, N. R., Pirmohamed, M., Back, D. J., & Park, B. K. (1999). The effect of genetic polymorphisms in CYP2C9 on sulphamethoxazole N-hydroxylation. PHARMACOGENETICS, 9(1), 43-53. doi:10.1097/00008571-199902000-00007

DOI: 10.1097/00008571-199902000-00007

1998

Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs (Journal article)

Naisbitt, D. J., Williams, D. P., O'Neill, P. M., Maggs, J. L., Willock, D. J., Pirmohamed, M., & Park, B. K. (1998). Metabolism-dependent neutrophil cytotoxicity of amodiaquine: A comparison with pyronaridine and related antimalarial drugs. CHEMICAL RESEARCH IN TOXICOLOGY, 11(12), 1586-1595. doi:10.1021/tx980148k

DOI: 10.1021/tx980148k

Safety assessment of peroxide antimalarials: clinical and chemical perspectives (Journal article)

Park, B. K., O'Neill, P. M., Maggs, J. L., & Pirmohamed, M. (1998). Safety assessment of peroxide antimalarials: clinical and chemical perspectives. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 46(6), 521-529. doi:10.1046/j.1365-2125.1998.00838.x

DOI: 10.1046/j.1365-2125.1998.00838.x

Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype (Journal article)

Powell, H., Kitteringham, N. R., Pirmohamed, M., Smith, D. A., & Park, B. K. (1998). Expression of cytochrome P4502E1 in human liver: assessment by mRNA, genotype and phenotype. PHARMACOGENETICS, 8(5), 411-421. doi:10.1097/00008571-199810000-00006

DOI: 10.1097/00008571-199810000-00006

Role of drug disposition in drug hypersensitivity: A chemical, molecular, and clinical perspective (Journal article)

Park, B. E., Pirmohamed, M., & Kitteringham, N. R. (1998). Role of drug disposition in drug hypersensitivity: A chemical, molecular, and clinical perspective. CHEMICAL RESEARCH IN TOXICOLOGY, 11(9), 969-988. doi:10.1021/tx980058f

DOI: 10.1021/tx980058f

No association between tacrine transaminitis and the glutathione transferase theta genotype in patients with Alzheimer's disease (Journal article)

De Sousa, M., Pirmohamed, M., Kitteringham, N. R., Woolf, T., & Park, B. K. (1998). No association between tacrine transaminitis and the glutathione transferase theta genotype in patients with Alzheimer's disease. PHARMACOGENETICS, 8(4), 353-355. Retrieved from http://gateway.webofknowledge.com/

Fortnightly review - Adverse drug reactions (Journal article)

Pirmohamed, M., Breckenridge, A. M., Kitteringham, N. R., & Park, B. K. (1998). Fortnightly review - Adverse drug reactions. BRITISH MEDICAL JOURNAL, 316(7140), 1295-1298. doi:10.1136/bmj.316.7140.1295

DOI: 10.1136/bmj.316.7140.1295

Risperidone-induced photosensitivity (Journal article)

Almond, D. S., Rhodes, L. E., & Pirmohamed, M. (1998). Risperidone-induced photosensitivity. POSTGRADUATE MEDICAL JOURNAL, 74(870), 252-253. doi:10.1136/pgmj.74.870.252

DOI: 10.1136/pgmj.74.870.252

Reporting of adverse drug reactions: practice in the UK. (Journal article)

Morrison-Griffiths, S., Pirmohamed, M., & Walley, T. (1998). Reporting of adverse drug reactions: practice in the UK.. Nursing times, 94(10), 52-54.

3 The pharmacology of the cytochrome P450 enzyme system (Journal article)

Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (1998). 3 The pharmacology of the cytochrome P450 enzyme system. Baillière's Clinical Anaesthesiology, 12(2), 191-211. doi:10.1016/s0950-3501(98)80028-7

DOI: 10.1016/s0950-3501(98)80028-7

Polymorphisms in the interleukin I cytokine gene family are not involved in adverse reactions to carbamazepine or tacrine. (Conference Paper)

Kitteringham, N. R., Pirmohamed, M., Wakil, L., Woolf, T., & Park, B. K. (1998). Polymorphisms in the interleukin I cytokine gene family are not involved in adverse reactions to carbamazepine or tacrine.. In NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY Vol. 358 (pp. R432). Retrieved from http://gateway.webofknowledge.com/

1997

Chapter 37 Idiosyncratic drug reactions (Journal article)

Pirmohamed, M., & Park, B. K. (1997). Chapter 37 Idiosyncratic drug reactions. Unknown Journal, 737-761. doi:10.1016/s1569-2582(97)80098-0

DOI: 10.1016/s1569-2582(97)80098-0

Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis (Journal article)

Williams, D. P., Pirmohamed, M., Naisbitt, D. J., Maggs, J. L., & Park, B. K. (1997). Neutrophil cytotoxicity of the chemically reactive metabolite(s) of clozapine: Possible role in agranulocytosis. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 283(3), 1375-1382. Retrieved from http://gateway.webofknowledge.com/

Polymorphism in gene for microsomal epoxide hydrolase and lung disease (multiple letters) [7] (Journal article)

Pirmohamed, M., Kitteringham, N. R., Park, B. K., Smith, C. A. D., Harrison, D. J., Paolini, M., & Chieco, P. (1997). Polymorphism in gene for microsomal epoxide hydrolase and lung disease (multiple letters) [7]. Lancet, 350(9090), 1553-1554. doi:10.1016/s0140-6736(05)63988-8

DOI: 10.1016/s0140-6736(05)63988-8

Polymorphism in gene for microsomal epoxide hydrolase and lung disease (Journal article)

Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (1997). Polymorphism in gene for microsomal epoxide hydrolase and lung disease. LANCET, 350(9090), 1553. doi:10.1016/S0140-6736(05)63988-8

DOI: 10.1016/S0140-6736(05)63988-8

Comparison of the metabolism and toxicity of dapsone in rat, mouse and man (Journal article)

Tingle, M. D., Mahmud, R., Maggs, J. L., Pirmohamed, M., & Park, B. K. (1997). Comparison of the metabolism and toxicity of dapsone in rat, mouse and man. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 283(2), 817-823. Retrieved from http://gateway.webofknowledge.com/

The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat (Journal article)

Gill, H. J., Hough, S. J., Naisbitt, D. J., Maggs, J. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (1997). The relationship between the disposition and immunogenicity of sulfamethoxazole in the rat. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 282(2), 795-801. Retrieved from http://gateway.webofknowledge.com/

Hepatitis B vaccine and neurotoxicity (Journal article)

Pirmohamed, M., & Winstanley, P. (1997). Hepatitis B vaccine and neurotoxicity. POSTGRADUATE MEDICAL JOURNAL, 73(861), 462-463. doi:10.1136/pgmj.73.861.462

DOI: 10.1136/pgmj.73.861.462

Characterisation of the toxic metabolite(s) of naphthalene (vol 114, pg 233, 1996) (Journal article)

Wilson, A. S., Davis, C. D., Williams, D. P., Buckpitt, A. R., Pirmohamed, M., & Park, B. K. (1997). Characterisation of the toxic metabolite(s) of naphthalene (vol 114, pg 233, 1996). TOXICOLOGY, 120(1), 75. Retrieved from http://gateway.webofknowledge.com/

Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design (Journal article)

Naisbitt, D. J., Ruscoe, J. E., Williams, D., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1997). Disposition of amodiaquine and related antimalarial agents in human neutrophils: Implications for drug design. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 280(2), 884-893. Retrieved from http://gateway.webofknowledge.com/

Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography mass spectrometry (Journal article)

Maggs, J. L., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (1997). Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography mass spectrometry. DRUG METABOLISM AND DISPOSITION, 25(3), 275-280. Retrieved from http://gateway.webofknowledge.com/

Antiprotozoal drugs (Journal article)

Pirmohamed, M., & Winstanley, P. A. (1997). Antiprotozoal drugs. Unknown Journal, 257-268. doi:10.1016/s0378-6080(05)80390-3

DOI: 10.1016/s0378-6080(05)80390-3

Corrigendum (Journal article)

Corrigendum (1997). Toxicology, 120(1), 75. doi:10.1016/s0300-483x(96)03644-x

DOI: 10.1016/s0300-483x(96)03644-x

Mechanism of clozapine-induced agranulocytosis - Current status of research and implications for drug development (Journal article)

Pirmohamed, M., & Park, K. (1997). Mechanism of clozapine-induced agranulocytosis - Current status of research and implications for drug development. CNS DRUGS, 7(2), 139-158. doi:10.2165/00023210-199707020-00005

DOI: 10.2165/00023210-199707020-00005

Nurses' confidence in caring for patients with alcohol-related problems. (Journal article)

Brown, C., Pirmohamed, M., & Park, B. K. (1997). Nurses' confidence in caring for patients with alcohol-related problems.. Professional nurse (London, England), 13(2), 83-86.

1996

Characterisation of the toxic metabolite(s) of naphthalene (Journal article)

Wilson, A. S., Davis, C. D., Williams, D. P., Buckpitt, A. R., Pirmohamed, M., & Park, B. K. (1996). Characterisation of the toxic metabolite(s) of naphthalene. TOXICOLOGY, 114(3), 233-242. doi:10.1016/S0300-483X(96)03515-9

DOI: 10.1016/S0300-483X(96)03515-9

Bioactivation of carbamazepine in the rat in vivo (Journal article)

Madden, S., Maggs, J. L., Kitteringham, N. R., Pirmohamed, M., & Park, B. K. (1996). Bioactivation of carbamazepine in the rat in vivo. British Journal of Clinical Pharmacology, 41(5).

Glutathione S-transferase T1 polymorphism and susceptibility to carbamazepine hypersensitivity (Journal article)

Allott, R. L., Pirmohamed, M., Kitteringham, N. R., & Park, B. K. (1996). Glutathione S-transferase T1 polymorphism and susceptibility to carbamazepine hypersensitivity. British Journal of Clinical Pharmacology, 41(5).

Investigation of the role of the TNF alpha gene polymorphism in alcoholic liver disease (ALD). (Conference Paper)

Allott, R. L., Quest, L. J., Pirmohamed, M., Kitteringham, N. R., Gilmore, I. T., & Park, B. K. (1996). Investigation of the role of the TNF alpha gene polymorphism in alcoholic liver disease (ALD).. In HEPATOLOGY Vol. 24 (pp. 1266). Retrieved from http://gateway.webofknowledge.com/

Relevance of induction of human drug-metabolizing enzymes: Pharmacological and toxicological implications (vol 41, pg 477, 1996) (Journal article)

Park, B. K., Kitteringham, N. R., Pirmohamed, M., & Tucker, G. T. (1996). Relevance of induction of human drug-metabolizing enzymes: Pharmacological and toxicological implications (vol 41, pg 477, 1996). BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 42(4), U1. Retrieved from http://gateway.webofknowledge.com/

Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: Studies, with cis-stilbene oxide, carbamazepine 10,11-epoxide and naphthalene (Journal article)

Kitteringham, N. R., Davis, C., Howard, N., Pirmohamed, M., & Park, B. K. (1996). Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: Studies, with cis-stilbene oxide, carbamazepine 10,11-epoxide and naphthalene. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 278(3), 1018-1027. Retrieved from http://gateway.webofknowledge.com/

Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity. (Journal article)

Naisbitt, D. J., ONeill, P. M., Pirmohamed, M., & Park, B. K. (1996). Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity.. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 6(13), 1511-1516. doi:10.1016/S0960-894X(96)00260-0

DOI: 10.1016/S0960-894X(96)00260-0

Lack of association between schizophrenia and the CYP2D6 gene polymorphisms (Journal article)

Pirmohamed, M., Wild, M. J., Kitteringham, N. R., OBrien, K., Buchan, I. E., Back, D. J., & Park, B. K. (1996). Lack of association between schizophrenia and the CYP2D6 gene polymorphisms. AMERICAN JOURNAL OF MEDICAL GENETICS, 67(2), 236-237. doi:10.1002/ajmg.1320670205

DOI: 10.1002/ajmg.1320670205

Hydralazine-induced lupus: Yet another autoantibody! Triplex-DNA stabilization by hydrazazine and the presence of anti-(triplex DNA) antibodies in patients treated with hydralazine - Comment (Journal article)

Pirmohamed, M. (1996). Hydralazine-induced lupus: Yet another autoantibody! Triplex-DNA stabilization by hydrazazine and the presence of anti-(triplex DNA) antibodies in patients treated with hydralazine - Comment. HUMAN & EXPERIMENTAL TOXICOLOGY, 15(4), 361-362. doi:10.1177/096032719601500413

DOI: 10.1177/096032719601500413

Hydralazine-induced lupus: yet another autoantibody! (Journal article)

Pirmohamed, M. (1996). Hydralazine-induced lupus: yet another autoantibody!. Human & experimental toxicology, 15(4), 361-362. doi:10.1177/096032719601500413

DOI: 10.1177/096032719601500413

Idiosyncratic drug reactions - Metabolic bioactivation as a pathogenic mechanism (Journal article)

Pirmohamed, M., Madden, S., & Park, B. K. (1996). Idiosyncratic drug reactions - Metabolic bioactivation as a pathogenic mechanism. CLINICAL PHARMACOKINETICS, 31(3), 215-230. doi:10.2165/00003088-199631030-00005

DOI: 10.2165/00003088-199631030-00005

Intracellular glutathione in the peripheral blood cells of HIV-infected patients: Failure to show a deficiency (Journal article)

Pirmohamed, M., Williams, D., Tingle, M. D., Barry, M., Khoo, S. H., OMahony, C., . . . Park, B. K. (1996). Intracellular glutathione in the peripheral blood cells of HIV-infected patients: Failure to show a deficiency. AIDS, 10(5), 501-507. doi:10.1097/00002030-199605000-00008

DOI: 10.1097/00002030-199605000-00008

Relevance of induction of human drug-metabolizing enzymes: Pharmacological and toxicological implications (Journal article)

Park, B. K., Kitteringham, N. R., Pirmohamed, M., & Tucker, G. T. (1996). Relevance of induction of human drug-metabolizing enzymes: Pharmacological and toxicological implications. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 41(6), 477-491. doi:10.1046/j.1365-2125.1996.03482.x

DOI: 10.1046/j.1365-2125.1996.03482.x

The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole (Journal article)

Gill, H. J., Maggs, J. L., Madden, S., Pirmohamed, M., & Park, K. (1996). The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 42(3), 347-353. doi:10.1046/j.1365-2125.1996.40110.x

DOI: 10.1046/j.1365-2125.1996.40110.x

Toxicology elsewhere (Journal article)

Pirmohamed, M. (1996). Toxicology elsewhere. Human & Experimental Toxicology, 15(4), 361-362. doi:10.1177/096032719601500413

DOI: 10.1177/096032719601500413

1995

The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man (Journal article)

Maggs, J. L., Williams, D., Pirmohamed, M., & Park, B. K. (1995). The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 275(3), 1463-1475. Retrieved from http://gateway.webofknowledge.com/

GENETIC-ANALYSIS OF MICROSOMAL EPOXIDE HYDROLASE IN PATIENTS WITH CARBAMAZEPINE HYPERSENSITIVITY (Journal article)

GREEN, V. J., PIRMOHAMED, M., KITTERINGHAM, N. R., GAEDIGK, A., GRANT, D. M., BOXER, M., . . . PARK, B. K. (1995). GENETIC-ANALYSIS OF MICROSOMAL EPOXIDE HYDROLASE IN PATIENTS WITH CARBAMAZEPINE HYPERSENSITIVITY. BIOCHEMICAL PHARMACOLOGY, 50(9), 1353-1359. doi:10.1016/0006-2952(95)02009-8

DOI: 10.1016/0006-2952(95)02009-8

KINETIC-PARAMETERS OF LYMPHOCYTE MICROSOMAL EPOXIDE HYDROLASE IN CARBAMAZEPINE HYPERSENSITIVE PATIENTS - ASSESSMENT BY RADIOMETRIC HPLC (Journal article)

DAVIS, C. D., PIRMOHAMED, M., KITTERINGHAM, N. R., ALLOTT, R. L., SMITH, D., & PARK, B. K. (1995). KINETIC-PARAMETERS OF LYMPHOCYTE MICROSOMAL EPOXIDE HYDROLASE IN CARBAMAZEPINE HYPERSENSITIVE PATIENTS - ASSESSMENT BY RADIOMETRIC HPLC. BIOCHEMICAL PHARMACOLOGY, 50(9), 1361-1366. doi:10.1016/0006-2952(95)02008-X

DOI: 10.1016/0006-2952(95)02008-X

Antiprotozoal drugs (Journal article)

Pirmohamed, M., & Winstanley, P. A. (1995). Antiprotozoal drugs. Unknown Journal, 262-272. doi:10.1016/s0378-6080(05)80153-9

DOI: 10.1016/s0378-6080(05)80153-9

Conference reports - Therapeutics 1995 - Abstracts (Journal article)

Pirmohamed, M., & Martin, U. (1995). Conference reports - Therapeutics 1995 - Abstracts. JOURNAL OF THE ROYAL COLLEGE OF PHYSICIANS OF LONDON, 29(6), 530-534. Retrieved from http://gateway.webofknowledge.com/

GLUTATHIONE-S-TRANSFERASE-MU GENOTYPE (GSTM1-ASTERISK-0) IN ALZHEIMERS PATIENTS WITH TACRINE TRANSAMINITIS (Journal article)

GREEN, V. J., PIRMOHAMED, M., KITTERINGHAM, N. R., KNAPP, M. J., & PARK, B. K. (1995). GLUTATHIONE-S-TRANSFERASE-MU GENOTYPE (GSTM1-ASTERISK-0) IN ALZHEIMERS PATIENTS WITH TACRINE TRANSAMINITIS. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 39(4), 411-415. doi:10.1111/j.1365-2125.1995.tb04470.x

DOI: 10.1111/j.1365-2125.1995.tb04470.x

Genetic polymorphism of cytochrome P4502E1 and risk of alcoholic liver disease in Caucasians (Journal article)

Pirmohamed, M., Kitteringham, N. R., Quest, L. J., Allott, R. L., Green, V. J., Gilmore, I. T., & Park, B. K. (1995). Genetic polymorphism of cytochrome P4502E1 and risk of alcoholic liver disease in Caucasians. PHARMACOGENETICS, 5(6), 351-357. doi:10.1097/00008571-199512000-00003

DOI: 10.1097/00008571-199512000-00003

METABOLISM AND BIOACTIVATION OF CLOZAPINE BY HUMAN LIVER IN-VITRO (Journal article)

PIRMOHAMED, M., WILLIAMS, D., MADDEN, S., TEMPLETON, E., & PARK, B. K. (1995). METABOLISM AND BIOACTIVATION OF CLOZAPINE BY HUMAN LIVER IN-VITRO. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 272(3), 984-990. Retrieved from http://gateway.webofknowledge.com/

Metabolism and bioactivation of clozapine by human liver in vitro. (Journal article)

Pirmohamed, M., Williams, D., Madden, S., Templeton, E., & Park, B. K. (1995). Metabolism and bioactivation of clozapine by human liver in vitro.. J Pharmacol Exp Ther., 3(273), 984-990.

The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity (Journal article)

Park, B. K., Pirmohamed, M., & Kitteringham, N. R. (1995). The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity. PHARMACOLOGY & THERAPEUTICS, 68(3), 385-424. doi:10.1016/0163-7258(95)02013-6

DOI: 10.1016/0163-7258(95)02013-6

Therapeutics 1995. (Journal article)

Pirmohamed, M., & Martin, U. (1995). Therapeutics 1995.. Journal of the Royal College of Physicians of London, 29(6), 530-534.

1994

ASSOCIATION BETWEEN CYTOCHROME-P450-2E1 (CYP2E1) RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM AND ALCOHOLIC LIVER-DISEASE IN CAUCASIANS (Conference Paper)

PIRMOHAMED, M., QUEST, L. J., KITTERINGHAM, N. R., ALLOTT, R. A., GILMORE, I. T., & PARK, B. K. (1994). ASSOCIATION BETWEEN CYTOCHROME-P450-2E1 (CYP2E1) RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM AND ALCOHOLIC LIVER-DISEASE IN CAUCASIANS. In HEPATOLOGY Vol. 20 (pp. A317). Retrieved from http://gateway.webofknowledge.com/

INVESTIGATION OF MECHANISMS IN TOXIC EPIDERMAL NECROLYSIS INDUCED BY CARBAMAZEPINE (Journal article)

FRIEDMANN, P. S., STRICKLAND, I., PIRMOHAMED, M., & PARK, B. K. (1994). INVESTIGATION OF MECHANISMS IN TOXIC EPIDERMAL NECROLYSIS INDUCED BY CARBAMAZEPINE. ARCHIVES OF DERMATOLOGY, 130(5), 598-604. doi:10.1001/archderm.130.5.598

DOI: 10.1001/archderm.130.5.598

Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine. (Journal article)

Friedmann, P. S., Strickland, I., Pirmohamed, M., & Park, B. K. (1994). Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine.. Archives of dermatology, 130(5), 598-604. doi:10.1001/archderm.1994.01690050066011

DOI: 10.1001/archderm.1994.01690050066011

Antiprotozoal drugs (Journal article)

Pirmohamed, M., & Winstanley, P. A. (1994). Antiprotozoal drugs. Unknown Journal, 286-298. doi:10.1016/s0378-6080(05)80273-9

DOI: 10.1016/s0378-6080(05)80273-9

BIOACTIVATION AND BIOINACTIVATION OF DRUGS AND DRUG METABOLITES - RELEVANCE TO ADVERSE DRUG-REACTIONS (Journal article)

PARK, B. K., PIRMOHAMED, M., TINGLE, M. D., MADDEN, S., & KITTERINGHAM, N. R. (1994). BIOACTIVATION AND BIOINACTIVATION OF DRUGS AND DRUG METABOLITES - RELEVANCE TO ADVERSE DRUG-REACTIONS. TOXICOLOGY IN VITRO, 8(4), 613-621. doi:10.1016/0887-2333(94)90029-9

DOI: 10.1016/0887-2333(94)90029-9

LYMPHOCYTE MICROSOMAL EPOXIDE HYDROLASE IN PATIENTS ON CARBAMAZEPINE THERAPY (Journal article)

PIRMOHAMED, M., ALLOTT, R., GREEN, V. J., KITTERINGHAM, N. R., CHADWICK, D., & PARK, B. K. (1994). LYMPHOCYTE MICROSOMAL EPOXIDE HYDROLASE IN PATIENTS ON CARBAMAZEPINE THERAPY. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 37(6), 577-581. doi:10.1111/j.1365-2125.1994.tb04307.x

DOI: 10.1111/j.1365-2125.1994.tb04307.x

THE ROLE OF ACTIVE METABOLITES IN DRUG TOXICITY (Journal article)

PIRMOHAMED, M., KITTERINGHAM, N. R., & PARK, B. K. (1994). THE ROLE OF ACTIVE METABOLITES IN DRUG TOXICITY. DRUG SAFETY, 11(2), 114-144. doi:10.2165/00002018-199411020-00006

DOI: 10.2165/00002018-199411020-00006

1993

AN INVESTIGATION OF THE FORMATION OF CYTOTOXIC, GENOTOXIC, PROTEIN-REACTIVE AND STABLE METABOLITES FROM NAPHTHALENE BY HUMAN LIVER-MICROSOMES (Journal article)

TINGLE, M. D., PIRMOHAMED, M., TEMPLETON, E., WILSON, A. S., MADDEN, S., KITTERINGHAM, N. R., & PARK, B. K. (1993). AN INVESTIGATION OF THE FORMATION OF CYTOTOXIC, GENOTOXIC, PROTEIN-REACTIVE AND STABLE METABOLITES FROM NAPHTHALENE BY HUMAN LIVER-MICROSOMES. BIOCHEMICAL PHARMACOLOGY, 46(9), 1529-1538. doi:10.1016/0006-2952(93)90319-R

DOI: 10.1016/0006-2952(93)90319-R

INTERACTION OF METOPROLOL AND FLUOXETINE (Journal article)

WALLEY, T., PIRMOHAMED, M., PROUDLOVE, C., & MAXWELL, D. (1993). INTERACTION OF METOPROLOL AND FLUOXETINE. LANCET, 341(8850), 967-968. doi:10.1016/0140-6736(93)91265-N

DOI: 10.1016/0140-6736(93)91265-N

LACK OF INTERACTION BETWEEN SULFASALAZINE AND CIMETIDINE IN PATIENTS WITH RHEUMATOID-ARTHRITIS (Journal article)

PIRMOHAMED, M., COLEMAN, M. D., GALVANI, D., BUCKNALL, R. C., BRECKENRIDGE, A. M., & PARK, B. K. (1993). LACK OF INTERACTION BETWEEN SULFASALAZINE AND CIMETIDINE IN PATIENTS WITH RHEUMATOID-ARTHRITIS. BRITISH JOURNAL OF RHEUMATOLOGY, 32(3), 222-226. Retrieved from http://gateway.webofknowledge.com/

Antiprotozoal drugs (Journal article)

Pirmohamed, M., & Winstanley, P. A. (1993). Antiprotozoal drugs. Unknown Journal, 325-336. doi:10.1016/s0378-6080(05)80212-0

DOI: 10.1016/s0378-6080(05)80212-0

PREDICTION OF IDIOSYNCRATIC DRUG REACTIONS (Journal article)

Pirmohamed, M., & Park, B. K. (1993). PREDICTION OF IDIOSYNCRATIC DRUG REACTIONS. Adverse Drug Reaction Bulletin, 163(1), 615. doi:10.1097/00012995-199312000-00001

DOI: 10.1097/00012995-199312000-00001

1992

THE EFFECT OF ENZYME-INDUCTION ON THE CYTOCHROME-P450-MEDIATED BIOACTIVATION OF CARBAMAZEPINE BY MOUSE-LIVER MICROSOMES (Journal article)

PIRMOHAMED, M., KITTERINGHAM, N. R., BRECKENRIDGE, A. M., & PARK, B. K. (1992). THE EFFECT OF ENZYME-INDUCTION ON THE CYTOCHROME-P450-MEDIATED BIOACTIVATION OF CARBAMAZEPINE BY MOUSE-LIVER MICROSOMES. BIOCHEMICAL PHARMACOLOGY, 44(12), 2307-2314. doi:10.1016/0006-2952(92)90674-8

DOI: 10.1016/0006-2952(92)90674-8

AN INVESTIGATION OF THE FORMATION OF CYTOTOXIC, PROTEIN-REACTIVE AND STABLE METABOLITES FROM CARBAMAZEPINE INVITRO (Journal article)

PIRMOHAMED, M., KITTERINGHAM, N. R., GUENTHNER, T. M., BRECKENRIDGE, A. M., & PARK, B. K. (1992). AN INVESTIGATION OF THE FORMATION OF CYTOTOXIC, PROTEIN-REACTIVE AND STABLE METABOLITES FROM CARBAMAZEPINE INVITRO. BIOCHEMICAL PHARMACOLOGY, 43(8), 1675-1682. doi:10.1016/0006-2952(92)90696-G

DOI: 10.1016/0006-2952(92)90696-G

Bioactivation of lofepramine to a cytotoxic metabolite by human and mouse liver microsomes (Conference Paper)

Pirmohamed, M., Templeton, E., Breckenridge, A. M., & Park, B. K. (1992). Bioactivation of lofepramine to a cytotoxic metabolite by human and mouse liver microsomes. In British Journal of Clinical Pharmacology Vol. 33.

DETECTION OF AN AUTOANTIBODY DIRECTED AGAINST HUMAN LIVER MICROSOMAL PROTEIN IN A PATIENT WITH CARBAMAZEPINE HYPERSENSITIVITY (Journal article)

PIRMOHAMED, M., KITTERINGHAM, N. R., BRECKENRIDGE, A. M., & PARK, B. K. (1992). DETECTION OF AN AUTOANTIBODY DIRECTED AGAINST HUMAN LIVER MICROSOMAL PROTEIN IN A PATIENT WITH CARBAMAZEPINE HYPERSENSITIVITY. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 33(2), 183-186. doi:10.1111/j.1365-2125.1992.tb04022.x

DOI: 10.1111/j.1365-2125.1992.tb04022.x

IDIOSYNCRATIC DRUG-REACTIONS - A MECHANISTIC EVALUATION OF RISK-FACTORS (Journal article)

PARK, B. K., PIRMOHAMED, M., & KITTERINGHAM, N. R. (1992). IDIOSYNCRATIC DRUG-REACTIONS - A MECHANISTIC EVALUATION OF RISK-FACTORS. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 34(5), 377-395. doi:10.1111/j.1365-2125.1992.tb05647.x

DOI: 10.1111/j.1365-2125.1992.tb05647.x

IDIOSYNCRATIC REACTIONS TO ANTIDEPRESSANTS - A REVIEW OF THE POSSIBLE MECHANISMS AND PREDISPOSING FACTORS (Journal article)

PIRMOHAMED, M., KITTERINGHAM, N. R., & PARK, B. K. (1992). IDIOSYNCRATIC REACTIONS TO ANTIDEPRESSANTS - A REVIEW OF THE POSSIBLE MECHANISMS AND PREDISPOSING FACTORS. PHARMACOLOGY & THERAPEUTICS, 53(1), 105-125. doi:10.1016/0163-7258(92)90046-3

DOI: 10.1016/0163-7258(92)90046-3

In vitro bioactivation of clozapine to a chemically reactive metabolite by human and mouse liver microsomes (Conference Paper)

Pirmohamed, M., Templeton, E., Breckenridge, A. M., & Park, B. K. (1992). In vitro bioactivation of clozapine to a chemically reactive metabolite by human and mouse liver microsomes. In British Journal of Clinical Pharmacology Vol. 34.

1991

CARBAMAZEPINE-HYPERSENSITIVITY - ASSESSMENT OF CLINICAL AND INVITRO CHEMICAL CROSS-REACTIVITY WITH PHENYTOIN AND OXCARBAZEPINE (Journal article)

PIRMOHAMED, M., GRAHAM, A., ROBERTS, P., SMITH, D., CHADWICK, D., BRECKENRIDGE, A. M., & PARK, B. K. (1991). CARBAMAZEPINE-HYPERSENSITIVITY - ASSESSMENT OF CLINICAL AND INVITRO CHEMICAL CROSS-REACTIVITY WITH PHENYTOIN AND OXCARBAZEPINE. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 32(6), 741-749. Retrieved from http://gateway.webofknowledge.com/

ANALYSIS OF MICROSOMAL EPOXIDE HYDROLASE LEVELS IN HUMAN TISSUES USING MONOCLONAL-ANTIBODIES (Conference Paper)

GUENTHNER, T. M., KUK, J., NGUYEN, M., WHEELER, C., & PIRMOHAMED, M. (1991). ANALYSIS OF MICROSOMAL EPOXIDE HYDROLASE LEVELS IN HUMAN TISSUES USING MONOCLONAL-ANTIBODIES. In FASEB JOURNAL Vol. 5 (pp. A1570). Retrieved from http://gateway.webofknowledge.com/

DIRECT AND METABOLISM-DEPENDENT TOXICITY OF SULFASALAZINE AND ITS PRINCIPAL METABOLITES TOWARDS HUMAN ERYTHROCYTES AND LEUKOCYTES (Journal article)

PIRMOHAMED, M., COLEMAN, M. D., HUSSAIN, F., BRECKENRIDGE, A. M., & PARK, B. K. (1991). DIRECT AND METABOLISM-DEPENDENT TOXICITY OF SULFASALAZINE AND ITS PRINCIPAL METABOLITES TOWARDS HUMAN ERYTHROCYTES AND LEUKOCYTES. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 32(3), 303-310. doi:10.1111/j.1365-2125.1991.tb03903.x

DOI: 10.1111/j.1365-2125.1991.tb03903.x

Use of an in vitro lymphocyte cytotoxicity assay to assess the effects of carbamazepine (CBZ), phenytoin (DPH) and oxcarbazepine (OXCZ) in carbamazepine-hypersensitive patients (Conference Paper)

Pirmohamed, M., Graham, A., Roberts, P., Smith, D., Chadwick, D. C., Breckenridge, A. M., & Park, B. K. (1991). Use of an in vitro lymphocyte cytotoxicity assay to assess the effects of carbamazepine (CBZ), phenytoin (DPH) and oxcarbazepine (OXCZ) in carbamazepine-hypersensitive patients. In British Journal of Clinical Pharmacology Vol. 31.

1990

PRESCRIBING IN EPILEPSY (Journal article)

PIRMOHAMED, M. (1990). PRESCRIBING IN EPILEPSY. PRACTITIONER, 234(1497), 1070-1072. Retrieved from http://gateway.webofknowledge.com/

1989

USE OF ADRENAL ARTERIAL EMBOLIZATION IN SEVERE ACTH-DEPENDENT CUSHINGS-SYNDROME (Journal article)

BLUNT, S. B., PIRMOHAMED, M., CHATTERJEE, V. K. K., BURRIN, J. M., ALLISON, D. J., & JOPLIN, G. F. (1989). USE OF ADRENAL ARTERIAL EMBOLIZATION IN SEVERE ACTH-DEPENDENT CUSHINGS-SYNDROME. POSTGRADUATE MEDICAL JOURNAL, 65(766), 575-579. doi:10.1136/pgmj.65.766.575

DOI: 10.1136/pgmj.65.766.575

Publications

2022

Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials (Journal article)

Factors Affecting Patient and Physician Engagement in Remote Health Care for Heart Failure: Systematic Review. (Journal article)

Ethnic Diversity and Warfarin Pharmacogenomics (Journal article)

Pharmacogenomics: Relevance and opportunities for clinical pharmacology (Journal article)

Similarity and Consistency Assessment of Three Major Online Drug-Drug Interaction Resources (Journal article)

DEVELOPMENT OF THE ANTICHOLINERGIC MEDICATION INDEX (ACMI) (Conference Paper)

T CELL-MEDIATED HYPERSENSITIVITY TO LUMACAFTOR AND IVACAFTOR IN CYSTIC FIBROSIS (Journal article)

A reference set of clinically relevant adverse drug-drug interactions (Journal article)

Checkpoint Inhibition Reduces the Threshold for Drug-Specific T-Cell Priming and Increases the Incidence of Sulfasalazine Hypersensitivity (Journal article)

A population study of clinically actionable genetic variation affecting drug response from the Middle East (Journal article)

Cardiovascular drugs and COVID-19 clinical outcomes: a systematic review and meta-analysis of randomized controlled trials (Journal article)

Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01. (Journal article)

A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers (Journal article)

Vitamin D, vitamin D-binding protein, free vitamin D and COVID-19 mortality in hospitalized patients (Journal article)

Challenges in cardiovascular pharmacogenomics implementation: a viewpoint from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy (Journal article)

Chromosomal Region 11p14.1 is Associated with Pharmacokinetics and Pharmacodynamics of Bisoprolol (Journal article)

Emerging technologies and their impact on regulatory science (Journal article)

Pharmacogenomics of Drug Hypersensitivity (Journal article)

Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm (Journal article)

2021

Plasma Methylmalonic Acid Concentration in Folic Acid-Supplemented Depressed Patients with Low or Marginal Vitamin B-12: A Randomized Trial (Journal article)

Genome-Wide association between EYA1 and Aspirin-induced peptic ulceration (Journal article)

Clinical and pharmacogenetic determinants of tenofovir-induced renal toxicity in HIV positive patients in Zambia (Conference Paper)

Development of an Adverse Event Reporting Button for a Veterinary Practice Management System (Conference Paper)

SJS/TEN 2019: From science to translation (vol 98, pg 2, 2020) (Journal article)

High-mobility group box 1 as a predictive biomarker for drug-resistant epilepsy: A proof-of-concept study (Journal article)

Roadmap to 2030 for Drug Evaluation in Older Adults (Journal article)

Assessing the impact of alcohol consumption on the genetic contribution to mean corpuscular volume (Journal article)

Corrigendum to ‘SJS/TEN 2019: From science to translation’ [J. Dermatol. Sci. 98/1 (2020) 2–12] (Journal article)

Developing and Validating a Clinical Warfarin Dose-Initiation Model for Black-African Patients in South Africa and Uganda (vol 109, pg 1564, 2021) (Journal article)

Factors Affecting Patient and Physician Engagement in Remote Health Care for Heart Failure: Systematic Review (Preprint) (Journal article)

HLA Allele-Restricted Immune-Mediated Adverse Drug Reactions: Framework for Genetic Prediction. (Journal article)

Improving anticoagulation in sub-Saharan Africa: What are the challenges and how can we overcome them? (Journal article)

Identification of ROBO2 as a Potential Locus Associated with Inhaled Corticosteroid Response in Childhood Asthma (Journal article)

AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter (Journal article)

Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01 (Journal article)

Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity (Journal article)

Cardiovascular drugs and COVID-19 clinical outcomes: A living systematic review and meta-analysis (Journal article)

Developing and Validating a Clinical Warfarin Dose-Initiation Model for Black-African Patients in South Africa and Uganda (Journal article)

Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine (Journal article)

The Interface of Therapeutics and Genomics in Cardiovascular Medicine (Journal article)

T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab (Journal article)

HLA-B*13:01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients (Journal article)

Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort (Journal article)

Genome-wide Association Study and Meta-analysis on Alcohol-Associated Liver Cirrhosis Identifies Genetic Risk Factors (Journal article)

Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use (Journal article)

Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing HLA-B*13:01 (Journal article)

HLA-DQB1 6672G > C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry (Journal article)

T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses (Journal article)

Combined analysis of transcriptomic and genetic data for the identification of loci involved in glucocorticosteroid response in asthma (Journal article)

Genetic risk factors in drug-induced liver injury due to isoniazid-containing anti-tuberculosis drug regimens. (Journal article)

Warfarin dosing algorithms: A systematic review (Journal article)

HLA Class-II. Restricted CD8(+) T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients (Journal article)

Anticoagulation in sub-Saharan Africa: Are Direct Oral Anticoagulants the answer? A review of lessons learnt from warfarin (Journal article)

A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COVID-19 (SARS-COV-2) treatments (Journal article)

Cutaneous expression of matrix metalloproteinase 9 in SJS/TEN: Putative role in the pathogenesis of epidermal detachment and possible therapeutic target (Conference Paper)

Dimethyl fumarate induced lymphopenia in multiple sclerosis: A review of the literature (Journal article)

Cardiovascular drugs and COVID-19 clinical outcomes: a living systematic review and meta-analysis (Journal article)

The role of pharmacogenomics in contemporary cardiovascular therapy: a position statement from the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy (Journal article)

Associations between occupation and heavy alcohol consumption in UK adults aged 40-69 years: a cross-sectional study using the UK Biobank (Journal article)

Inflammatory Bowel Disease: A Personalized Approach. (Journal article)

Pharmacogenomics of anticancer drugs: Personalising the choice and dose to manage drug response (Journal article)

Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex (Journal article)

Probenecid increases the concentration of 7-chlorokynurenic acid derived from the prodrug 4-chlorokynurenine within the prefrontal cortex (Conference Paper)

Sequential Association Rule Mining Revisited: A Study Directed at Relational Pattern Mining for Multi-morbidity (Conference Paper)

2020

Multimorbidity, polypharmacy, and drug-drug-gene interactions following a non-ST elevation acute coronary syndrome: analysis of a multicentre observational study (Journal article)

Examining the uptake of predictive BRCA testing in the UK; findings and implications (Journal article)

Monitoring indirect impact of COVID-19 pandemic on services for cardiovascular diseases in the UK (Journal article)

Pharmacogenomics for Primary Care: An Overview (Journal article)

Alcohol-related brain injury: An unrecognized problem in acute medicine (Journal article)

Characterization of Clozapine-Responsive Human T Cells (Journal article)

HLA DaB1*15:01-DQB1*06:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts (Journal article)

Pharmacogenomics in the UK National Health Service: opportunities and challenges (Journal article)

A Review of the Important Role of CYP2D6 in Pharmacogenomics (Journal article)

Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation (Journal article)

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation (Conference Paper)

Precision medicine in drug safety (Journal article)

HLA DaB115:01-DQB106:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts (Journal article)