Photo of Dr Massimiliano Stagi

Dr Massimiliano Stagi Dr.Rer.Nat (PhD)

Molecular & Physiology Cell Signalling

    Publications

    2021

    Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor (Journal article)

    Ponsford, A. H., Ryan, T. A., Raimondi, A., Cocucci, E., Wycislo, S. A., Fröhlich, F., . . . Stagi, M. (n.d.). Live imaging of intra-lysosome pH in cell lines and primary neuronal culture using a novel genetically encoded biosensor. Autophagy, 1-19. doi:10.1080/15548627.2020.1771858

    DOI: 10.1080/15548627.2020.1771858

    Multimodal Imaging of Synaptic Vesicles with a Single Probe (Journal article)

    An, S. J., Stagi, M., Gould, T. J., Wu, Y., Mlodzianoski, M., Strittmatter, S., . . . Zenisek, D. (n.d.). Multimodal Imaging of Synaptic Vesicles with a Single Probe. SSRN Electronic Journal. doi:10.2139/ssrn.3774447

    DOI: 10.2139/ssrn.3774447

    How mTORC1 makes sense of nutrients (Journal article)

    Luciani, A., & Stagi, M. (2021). How mTORC1 makes sense of nutrients. KIDNEY INTERNATIONAL, 99(2), 295-298. doi:10.1016/j.kint.2020.07.052

    DOI: 10.1016/j.kint.2020.07.052

    2019

    Lowe syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in Dictyostelium discoideum. (Journal article)

    Luscher, A., Fröhlich, F., Barisch, C., Littlewood, C., Metcalfe, J., Leuba, F., . . . Swan, L. E. (2019). Lowe syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in Dictyostelium discoideum.. Molecular biology of the cell, 30(17), 2268-2282. doi:10.1091/mbc.E18-08-0510

    DOI: 10.1091/mbc.E18-08-0510

    Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis (Journal article)

    Fernandez-Mosquera, L., Yambire, K. F., Renata, C., Pereyra, L., Pabis, K., Ponsford, A. H., . . . Raimundo, N. (2019). Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis. Autophagy, 15(9), 1572-1591. doi:10.1080/15548627.2019.1586256

    DOI: 10.1080/15548627.2019.1586256

    Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists (vol 26, pg 145, 2019) (Journal article)

    Gunther, E. C., Smith, L. M., Kostylev, M. A., Cox, T. O., Kaufman, A. C., Lee, S., . . . Strittmatter, S. M. (2019). Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists (vol 26, pg 145, 2019). CELL REPORTS, 26(5), 1368. doi:10.1016/j.celrep.2019.01.064

    DOI: 10.1016/j.celrep.2019.01.064

    2017

    Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice. (Journal article)

    Zoe Klein., Hideyuki Takahashi., Mengxiao Ma., Massimiliano Stagi., Melissa Zhou., TuKiet Lam., & Stephen M. Strittmatter. (2017). Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.. Neuron, 95(2), 281-296. doi:10.1016/j.neuron.2017.06.026

    DOI: 10.1016/j.neuron.2017.06.026

    Co-culture Synaptogenic Assay: A New Look at Fluorescence Reporters and Technological Devices. (Chapter)

    Perez de Arce, K., & Stagi, M. (2017). Co-culture Synaptogenic Assay: A New Look at Fluorescence Reporters and Technological Devices.. In Unknown Book (Vol. 1538, pp. 13-27). doi:10.1007/978-1-4939-6688-2_2

    DOI: 10.1007/978-1-4939-6688-2_2

    2015

    Low cost production of 3D-printed devices and electrostimulation chambers for the culture of primary neurons (Journal article)

    Wardyn, J., Sanderson, C., Swan, L., & Stagi, M. (2015). Low cost production of 3D-printed devices and electrostimulation chambers for the culture of primary neurons. Journal of Neuroscience Methods, 251, 17-23. doi:10.1016/j.jneumeth.2015.05.001

    DOI: 10.1016/j.jneumeth.2015.05.001

    Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury (Journal article)

    Zou, Y., Stagi, M., Wang, X., Yigitkanli, K., Siegel, C. S., Nakatsu, F., . . . Strittmatter, S. M. (2015). Gene-Silencing Screen for Mammalian Axon Regeneration Identifies Inpp5f (Sac2) as an Endogenous Suppressor of Repair after Spinal Cord Injury. The Journal of Neuroscience, 35(29), 10429-10439. doi:10.1523/JNEUROSCI.1718-15.2015

    DOI: 10.1523/JNEUROSCI.1718-15.2015

    2014

    Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B (Journal article)

    Stagi, M., Klein, Z. A., Gould, T. J., Bewersdorf, J., & Strittmatter, S. M. (2016). Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B. Molecular and Cellular Neuroscience, 61, 226-240. doi:10.1016/j.mcn.2014.07.006

    DOI: 10.1016/j.mcn.2014.07.006

    2013

    Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer A beta Oligomer Bound to Cellular Prion Protein (vol 79, pg 887, 2013) (Journal article)

    Um, J. W., Kaufman, A. C., Kostylev, M., Heiss, J. K., Stagi, M., Takahashi, H., . . . Strittmatter, S. M. (2013). Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer A beta Oligomer Bound to Cellular Prion Protein (vol 79, pg 887, 2013). NEURON, 80(2), 531. doi:10.1016/j.neuron.2013.10.001

    DOI: 10.1016/j.neuron.2013.10.001

    Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer A beta Oligomer Bound to Cellular Prion Protein (Journal article)

    Um, J. W., Kaufman, A. C., Kostylev, M., Heiss, J. K., Stagi, M., Takahashi, H., . . . Strittmatter, S. M. (2013). Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer A beta Oligomer Bound to Cellular Prion Protein. NEURON, 79(5), 887-902. doi:10.1016/j.neuron.2013.06.036

    DOI: 10.1016/j.neuron.2013.06.036

    2012

    Alzheimer amyloid-beta oligomer bound to postsynaptic prion protein activates Fyn to impair neurons (Journal article)

    Um, J. W., Nygaard, H. B., Heiss, J. K., Kostylev, M. A., Stagi, M., Vortmeyer, A., . . . Strittmatter, S. M. (2012). Alzheimer amyloid-beta oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. NATURE NEUROSCIENCE, 15(9), 1227-1U85. doi:10.1038/nn.3178

    DOI: 10.1038/nn.3178

    2011

    Lateral assembly of the immunoglobulin protein SynCAM 1 controls its adhesive function and instructs synapse formation (Journal article)

    Fogel, A. I., Stagi, M., de Arce, K. P., & Biederer, T. (2011). Lateral assembly of the immunoglobulin protein SynCAM 1 controls its adhesive function and instructs synapse formation. EMBO JOURNAL, 30(23), 4728-4738. doi:10.1038/emboj.2011.336

    DOI: 10.1038/emboj.2011.336

    2010

    SynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones (Journal article)

    Stagi, M., Fogel, A. I., & Biederer, T. (2010). SynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(16), 7568-7573. doi:10.1073/pnas.0911798107

    DOI: 10.1073/pnas.0911798107

    2008

    SynCAM complexes encode synaptic adhesion to organize nascent synapses (Conference Paper)

    Fogel, A. I., Stagi, M., Krupp, A., Stein, V., & Biederer, T. (2008). SynCAM complexes encode synaptic adhesion to organize nascent synapses. In INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE Vol. 26 (pp. 840). doi:10.1016/j.ijdevneu.2008.09.045

    DOI: 10.1016/j.ijdevneu.2008.09.045

    Signaling by synaptogenic molecules (Journal article)

    Biederer, T., & Stagi, M. (2008). Signaling by synaptogenic molecules. CURRENT OPINION IN NEUROBIOLOGY, 18(3), 261-269. doi:10.1016/j.conb.2008.07.014

    DOI: 10.1016/j.conb.2008.07.014

    2007

    SynCAMs organize synapses through heterophilic adhesion (Journal article)

    Fogel, A. I., Akins, M. R., Krupp, A. J., Stagi, M., Stein, V., & Biederer, T. (2007). SynCAMs organize synapses through heterophilic adhesion. JOURNAL OF NEUROSCIENCE, 27(46), 12516-12530. doi:10.1523/JNEUROSCI.2739-07.2007

    DOI: 10.1523/JNEUROSCI.2739-07.2007

    Tissue debris clearance by TREM2-transduced myeloid precursors in experimental autoimmune encephalomyelitis (Conference Paper)

    Takahashi, K., Prinz, M., Stagi, M., Chechneva, O., & Neumann, H. (2007). Tissue debris clearance by TREM2-transduced myeloid precursors in experimental autoimmune encephalomyelitis. In EUROPEAN JOURNAL OF NEUROLOGY Vol. 14 (pp. 130). Retrieved from http://gateway.webofknowledge.com/

    TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis (Journal article)

    Takahashi, K., Prinz, M., Stagi, M., Chechneva, O., & Neumann, H. (2007). TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLOS MEDICINE, 4(4), 675-689. doi:10.1371/journal.pmed.0040124

    DOI: 10.1371/journal.pmed.0040124

    2006

    Unloading kinesin transported cargoes from the tubulin track via the inflammatory c-Jun N-terminal kinase pathway (Journal article)

    Stagi, M., Gorlovoy, P., Larionov, S., Takahashi, K., & Neumann, H. (2006). Unloading kinesin transported cargoes from the tubulin track via the inflammatory c-Jun N-terminal kinase pathway. FASEB JOURNAL, 20(14), 2573-+. doi:10.1096/fj.06-6679fje

    DOI: 10.1096/fj.06-6679fje

    2005

    LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide (Journal article)

    Liu, Y., Walter, S., Stagi, M., Cherny, D., Letiembre, M., Schulz-Schaeffer, W., . . . Fassbender, K. (2005). LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide. BRAIN, 128, 1778-1789. doi:10.1093/brain/awh531

    DOI: 10.1093/brain/awh531

    Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide (Journal article)

    Stagi, M., Dittrich, P. S., Frank, N., Iliev, A. I., Schwille, P., & Neumann, H. (2005). Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide. JOURNAL OF NEUROSCIENCE, 25(2), 352-362. doi:10.1523/JNEUROSCI.3887-04.2005

    DOI: 10.1523/JNEUROSCI.3887-04.2005

    2004

    Effect of inflammatory mediators on axonal transport of synaptic vesicle proteins (Conference Paper)

    Stagi, M., Frank, N., & Neumann, H. (2004). Effect of inflammatory mediators on axonal transport of synaptic vesicle proteins. In JOURNAL OF NEUROIMMUNOLOGY Vol. 154 (pp. 168). Retrieved from http://gateway.webofknowledge.com/

    2003

    Effect of inflammatory mediators on axonal transport of synaptic vesicle proteins (Conference Paper)

    Stagi, M., Frank, N., & Neumann, H. (2003). Effect of inflammatory mediators on axonal transport of synaptic vesicle proteins. In GLIA (pp. 43). Retrieved from http://gateway.webofknowledge.com/