Photo of Em P Mark Caddick

Em P Mark Caddick BSc. PhD.

Professor Biochemistry & Systems Biology

    Publications

    2021

    Histone mRNA is subject to 3 ' uridylation and re-adenylation in Aspergillus nidulans (Journal article)

    Mossanen-Parsi, A., Parisi, D., Browne-Marke, N., Bharudin, I., Connell, S. R., Mayans, O., . . . Caddick, M. X. (2021). Histone mRNA is subject to 3 ' uridylation and re-adenylation in Aspergillus nidulans. MOLECULAR MICROBIOLOGY, 115(2), 238-254. doi:10.1111/mmi.14613

    DOI: 10.1111/mmi.14613

    2020

    Growing a circular economy with fungal biotechnology: a white paper. (Journal article)

    Meyer, V., Basenko, E. Y., Benz, J. P., Braus, G. H., Caddick, M. X., Csukai, M., . . . Wösten, H. A. B. (2020). Growing a circular economy with fungal biotechnology: a white paper.. Fungal biology and biotechnology, 7, 5. doi:10.1186/s40694-020-00095-z

    DOI: 10.1186/s40694-020-00095-z

    2019

    High-Quality Draft Genome Sequence and Annotation of the Basidiomycete Yeast Sporisorium graminicola CBS10092, a Producer of Mannosylerythritol Lipids. (Journal article)

    Solano-González, S., Darby, A. C., Cossar, D., & Caddick, M. X. (2019). High-Quality Draft Genome Sequence and Annotation of the Basidiomycete Yeast Sporisorium graminicola CBS10092, a Producer of Mannosylerythritol Lipids.. Microbiology resource announcements, 8(42). doi:10.1128/mra.00479-19

    DOI: 10.1128/mra.00479-19

    Building a global alliance of biofoundries (vol 10, 2040, 2019) (Journal article)

    Hillson, N., Caddick, M., Cai, Y., Carrasco, J. A., Chang, M. W., Curach, N. C., . . . Freemont, P. S. (2019). Building a global alliance of biofoundries (vol 10, 2040, 2019). NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-019-10862-1

    DOI: 10.1038/s41467-019-10862-1

    Similarity Regression predicts evolution of transcription factor sequence specificity (Journal article)

    Lambert, S. A., Yang, A., Sasse, A., Cowley, G., Albu, M., Caddick, M. X., . . . Hughes, T. R. (2019). Similarity Regression predicts evolution of transcription factor sequence specificity. Nature Genetics, 51, 981-989. doi:10.1038/s41588-019-0411-1

    DOI: 10.1038/s41588-019-0411-1

    Building a global alliance of biofoundries (Journal article)

    Hillson, N., Caddick, M., Cai, Y., Carrasco, J. A., Chang, M. W., Curach, N. C., . . . Freemont, P. S. (2019). Building a global alliance of biofoundries. NATURE COMMUNICATIONS, 10. doi:10.1038/s41467-019-10079-2

    DOI: 10.1038/s41467-019-10079-2

    The role of the GATA transcription factor AreB in regulation of nitrogen and carbon metabolism in Aspergillus nidulans (Journal article)

    Caddick, M. X. (2019). The role of the GATA transcription factor AreB in regulation of nitrogen and carbon metabolism in Aspergillus nidulans. FEMS Microbiology Letters. doi:10.1093/femsle/fnz066

    DOI: 10.1093/femsle/fnz066

    The role of the GATA transcription factor AreB in regulation of nitrogen and carbon metabolism in Aspergillus nidulans. (Journal article)

    Chudzicka-Ormaniec, P., Macios, M., Koper, M., Weedall, G., Caddick, M., Weglenski, P., & Dzikowska, A. (2019). The role of the GATA transcription factor AreB in regulation of nitrogen and carbon metabolism in Aspergillus nidulans.. FEMS Microbiology Letters, 366(6). doi:10.1093/femsle/fnz066

    DOI: 10.1093/femsle/fnz066

    2017

    The Role of eIF6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-Expression Networks (Journal article)

    Clarke, K., Ricciardi, S., Pearson, T., Bharudin, I., Davidsen, P. K., Bonomo, M., . . . Falciani, F. (2017). The Role of eIF6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-Expression Networks. Cell Reports, 21(6), 1507-1520. doi:10.1016/j.celrep.2017.10.040

    DOI: 10.1016/j.celrep.2017.10.040

    Leaf LIMS: A Flexible Laboratory Information Management System with a Synthetic Biology Focus. (Journal article)

    Craig, T., Holland, R., D'Amore, R., Johnson, J. R., McCue, H. V., West, A., . . . Caddick, M. X. (2017). Leaf LIMS: A Flexible Laboratory Information Management System with a Synthetic Biology Focus.. ACS synthetic biology, 6(12), 2273-2280. doi:10.1021/acssynbio.7b00212

    DOI: 10.1021/acssynbio.7b00212

    2016

    Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper. (Journal article)

    Meyer, V., Andersen, M. R., Brakhage, A. A., Braus, G. H., Caddick, M. X., Cairns, T. C., . . . Head, R. M. (2016). Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper.. Fungal biology and biotechnology, 3, 6. doi:10.1186/s40694-016-0024-8

    DOI: 10.1186/s40694-016-0024-8

    2015

    3' end mRNA tagging: A novel quality control mechanism that coordinates mRNA translation and degradation (Journal article)

    Morozov, I., & Caddick, M. X. (2015). 3' end mRNA tagging: A novel quality control mechanism that coordinates mRNA translation and degradation. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 36, S29. Retrieved from http://gateway.webofknowledge.com/

    2013

    Transcriptome analysis of the filamentous fungus Aspergillus nidulans directed to the global identification of promoters. (Journal article)

    Sibthorp, C., Wu, H., Cowley, G., Wong, P. W. H., Palaima, P., Morozov, I. Y., . . . Caddick, M. X. (2013). Transcriptome analysis of the filamentous fungus Aspergillus nidulans directed to the global identification of promoters.. BMC genomics, 14, 847. doi:10.1186/1471-2164-14-847

    DOI: 10.1186/1471-2164-14-847

    RrmA regulates the stability of specific transcripts in response to both nitrogen source and oxidative stress (Journal article)

    Krol, K., Morozov, I. Y., Jones, M. G., Wyszomirski, T., Weglenski, P., Dzikowska, A., & Caddick, M. X. (2013). RrmA regulates the stability of specific transcripts in response to both nitrogen source and oxidative stress. Molecular Microbiology, 89(5), 975-988. doi:10.1111/mmi.12324

    DOI: 10.1111/mmi.12324

    Finding DNA Regulatory Motifs with Position-dependent Models (Journal article)

    Wu, H., Wong, P. W. H., Caddick, M. X., & Sibthorp, C. (2013). Finding DNA Regulatory Motifs with Position-dependent Models. Journal of Medical and Bioengineering (JoMB), 2(2), 103-109.

    2012

    mRNA 3 ' Tagging Is Induced by Nonsense-Mediated Decay and Promotes Ribosome Dissociation (Journal article)

    Morozov, I. Y., Jones, M. G., Gould, P. D., Crome, V., Wilson, J. B., Hall, A. J. W., . . . Caddick, M. X. (2012). mRNA 3 ' Tagging Is Induced by Nonsense-Mediated Decay and Promotes Ribosome Dissociation. MOLECULAR AND CELLULAR BIOLOGY, 32(13), 2585-2595. doi:10.1128/MCB.00316-12

    DOI: 10.1128/MCB.00316-12

    The GATA factors AREA and AREB together with the co-repressor NMRA, negatively regulate arginine catabolism in Aspergillus nidulans in response to nitrogen and carbon source (Journal article)

    Macios, M., Caddick, M. X., Weglenski, P., Scazzocchio, C., & Dzikowska, A. (2012). The GATA factors AREA and AREB together with the co-repressor NMRA, negatively regulate arginine catabolism in Aspergillus nidulans in response to nitrogen and carbon source. Fungal Genetics and Biology, 49(3), 189-198. doi:10.1016/j.fgb.2012.01.004

    DOI: 10.1016/j.fgb.2012.01.004

    Cytoplasmic mRNA 3' tagging in eukaryotes: Does it spell the end? (Journal article)

    Morozov, I. Y., & Caddick, M. (2012). Cytoplasmic mRNA 3' tagging in eukaryotes: Does it spell the end?. Unknown Journal, 1.

    2011

    Title: Characterisation of AnBEST1, a functional anion channel in the plasma membrane of the filamentous fungus, Aspergillus nidulans (Journal article)

    Roberts, S. K., Milnes, J., & Caddick, M. (2011). Title: Characterisation of AnBEST1, a functional anion channel in the plasma membrane of the filamentous fungus, Aspergillus nidulans. FUNGAL GENETICS AND BIOLOGY, 48(9), 928-938.

    2010

    The bZIP Transcription Factor MeaB Mediates Nitrogen Metabolite Repression at Specific Loci (Journal article)

    Wagner, D., Schmeinck, A., Mos, M., Morozov, I. Y., Caddick, M. X., & Tudzynski, B. (2010). The bZIP Transcription Factor MeaB Mediates Nitrogen Metabolite Repression at Specific Loci. Eukaryotic Cell, 9(10), 1588-1601. doi:10.1128/ec.00146-10

    DOI: 10.1128/ec.00146-10

    CUCU Modification of mRNA Promotes Decapping and Transcript Degradation in Aspergillus nidulans (Journal article)

    Morozov, I. Y., Jones, M. G., Razak, A. A., Rigden, D. J., & Caddick, M. X. (2010). CUCU Modification of mRNA Promotes Decapping and Transcript Degradation in Aspergillus nidulans. MOLECULAR AND CELLULAR BIOLOGY, 30(2), 460-469. doi:10.1128/MCB.00997-09

    DOI: 10.1128/MCB.00997-09

    Blue Skies, Green Fields (Journal article)

    Caddick, M. X. (2010). Blue Skies, Green Fields. Public Service Review: UK Science and Technology, 1, 72.

    Distinct roles for Caf1, Ccr4, Edc3 and CutA in the co-ordination of transcript deadenylation, decapping and P-body formation in Aspergillus nidulans (Journal article)

    Morozov, I. Y., Jones, M. G., Spiller, D. G., Rigden, D. J., Dattenboeck, C., Novotny, R., . . . Caddick, M. X. (2010). Distinct roles for Caf1, Ccr4, Edc3 and CutA in the co-ordination of transcript deadenylation, decapping and P-body formation in Aspergillus nidulans. MOLECULAR MICROBIOLOGY, 76(2), 503-516. doi:10.1111/j.1365-2958.2010.07118.x

    DOI: 10.1111/j.1365-2958.2010.07118.x

    The bZIP transcription factor meaB mediates nitrogen metabolite repression at specific loci (Journal article)

    Wagner, D., Schmeinck, A., Mos, M., Morozov, I. Y., Caddick, M. X., & Tudzynski, B. (2010). The bZIP transcription factor meaB mediates nitrogen metabolite repression at specific loci. Eukaryotic Cell, 9(10), 1588-1601. doi:10.1128/EC.00146-10

    DOI: 10.1128/EC.00146-10

    mRNA stability and its role in biomedical sciences (Journal article)

    Morozov, I., & Caddick, M. X. (2010). mRNA stability and its role in biomedical sciences. Int J Mol Med, 26, s24.

    2007

    Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88 (Journal article)

    Pel, H. J., de Winde, J. H., Archer, D. B., Dyer, P. S., Hofmann, G., Schaap, P. J., . . . Stam, H. (2007). Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88. Nature Biotechnology, 25(2), 221-231. doi:10.1038/nbt1282

    DOI: 10.1038/nbt1282

    Applications of inducible transcription in plant research and biotechnology. (Chapter)

    Tomsett, A. B., Tregova, A., & Caddick, M. X. (2007). Applications of inducible transcription in plant research and biotechnology.. In K. D. Grasser (Ed.), In: Regulation of Transcription in Plants (Vol. 29, pp. 309-328). Oxford: Blackwells.

    Gene regulation (Chapter)

    Caddick, M. X., & Dobson, C. (2007). Gene regulation. In G. Goldman, & S. Osmani (Eds.), The Aspergilli: Genomics, Medical Applications, Biotechnology, and Research Methods. (pp. 153-161). New York: CRC Press.

    2006

    Nonsense-Mediated mRNA Decay Mutation in Aspergillus nidulans (Journal article)

    Morozov, I. Y., Negrete-Urtasun, S., Tilburn, J., Jansen, C. A., Caddick, M. X., & Arst, H. N. (2006). Nonsense-Mediated mRNA Decay Mutation in Aspergillus nidulans. Eukaryotic Cell, 5(11), 1838-1846. doi:10.1128/ec.00220-06

    DOI: 10.1128/ec.00220-06

    Opposing signals differentially regulate transcript stability inAspergillus nidulans (Journal article)

    Caddick, M. X., Jones, M. G., van Tonder, J. M., Le Cordier, H., Narendja, F., Strauss, J., & Morozov, I. Y. (2006). Opposing signals differentially regulate transcript stability inAspergillus nidulans. Molecular Microbiology, 62(2), 509-519. doi:10.1111/j.1365-2958.2006.05383.x

    DOI: 10.1111/j.1365-2958.2006.05383.x

    Gene regulation inAspergillus: From genetics to genomics (Journal article)

    Caddick, M. X., Dobson, C., Morozov, I. Y., & Jones, M. G. (2006). Gene regulation inAspergillus: From genetics to genomics. Medical Mycology, 44(s1), 13-16. doi:10.1080/13693780600835781

    DOI: 10.1080/13693780600835781

    The GATA factor AreA regulates localization andin vivobinding site occupancy of the nitrate activator NirA (Journal article)

    Berger, H., Pachlinger, R., Morozov, I., Goller, S., Narendja, F., Caddick, M., & Strauss, J. (2006). The GATA factor AreA regulates localization andin vivobinding site occupancy of the nitrate activator NirA. Molecular Microbiology, 59(2), 433-446. doi:10.1111/j.1365-2958.2005.04957.x

    DOI: 10.1111/j.1365-2958.2005.04957.x

    2005

    Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae (Journal article)

    Galagan, J. E., Calvo, S. E., Cuomo, C., Ma, L. -J., Wortman, J. R., Batzoglou, S., . . . Birren, B. W. (2005). Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature, 438(7071), 1105-1115. doi:10.1038/nature04341

    DOI: 10.1038/nature04341

    Genetic Analysis of the TOR Pathway in Aspergillus nidulans (Journal article)

    Fitzgibbon, G. J., Morozov, I. Y., Jones, M. G., & Caddick, M. X. (2005). Genetic Analysis of the TOR Pathway in Aspergillus nidulans. Eukaryotic Cell, 4(9), 1595-1598. doi:10.1128/ec.4.9.1595-1598.2005

    DOI: 10.1128/ec.4.9.1595-1598.2005

    The alc-GR System. A Modified alc Gene Switch Designed for Use in Plant Tissue Culture (Journal article)

    Roberts, G. R., Garoosi, G. A., Koroleva, O., Ito, M., Laufs, P., Leader, D. J., . . . Tomsett, A. B. (2005). The alc-GR System. A Modified alc Gene Switch Designed for Use in Plant Tissue Culture. Plant Physiology, 138(3), 1259-1267. doi:10.1104/pp.105.059659

    DOI: 10.1104/pp.105.059659

    Characterization of the ethanol-inducible alc gene expression system in tomato (Journal article)

    Garoosi, G. A., Salter, M. G., Caddick, M. X., & Tomsett, A. B. (2005). Characterization of the ethanol-inducible alc gene expression system in tomato. Journal of Experimental Botany, 56(416), 1635-1642. doi:10.1093/jxb/eri159

    DOI: 10.1093/jxb/eri159

    2004

    Nitrogen regulation in mycelial fungi. (Chapter)

    Caddick, M. X. (2004). Nitrogen regulation in mycelial fungi.. In R. Brambl, & G. A. Marzluf (Eds.), The Mycota III, Biochemistry and Molecular Biology (Vol. III, pp. 349-368). Berlin-Heidelberg: Springer-Verlag.

    2003

    A polyketide synthase gene required for ochratoxin A biosynthesis in Aspergillus ochraceus (Journal article)

    O'Callaghan, J., Caddick, M. X., & Dobson, A. D. W. (2003). A polyketide synthase gene required for ochratoxin A biosynthesis in Aspergillus ochraceus. Microbiology, 149(12), 3485-3491. doi:10.1099/mic.0.26619-0

    DOI: 10.1099/mic.0.26619-0

    Re: Watts et al. Proteins 2002;48:161-168 (Journal article)

    Arst, H. N., Nicholas, H. B., & Caddick, M. X. (2003). Re: Watts et al. Proteins 2002;48:161-168. Proteins: Structure, Function, and Genetics, 52(2), 125-128. doi:10.1002/prot.10447

    DOI: 10.1002/prot.10447

    Differential expression of cold- and diet-specific genes encoding two carp liver delta 9-acyl-CoA desaturase isoforms. (Journal article)

    Polley, S. D., Tiku, P. E., Trueman, R. T., Caddick, M. X., Morozov, I. Y., & Cossins, A. R. (2003). Differential expression of cold- and diet-specific genes encoding two carp liver delta 9-acyl-CoA desaturase isoforms.. American journal of physiology. Regulatory, integrative and comparative physiology, 284(1), R41-R50. doi:10.1152/ajpregu.00263.2002

    DOI: 10.1152/ajpregu.00263.2002

    2002

    The role of desaturases in cold-induced lipid restructuring (Journal article)

    Cossins, A. R., Murray, P. A., Gracey, A. Y., Logue, J., Polley, S., Caddick, M., . . . Maclean, N. (2002). The role of desaturases in cold-induced lipid restructuring. BIOCHEMICAL SOCIETY TRANSACTIONS, 30, 1082-1086. doi:10.1042/bst0301082

    DOI: 10.1042/bst0301082

    The role of desaturases in cold-induced lipid restructuring (Journal article)

    Cossins, A. R., Murray, P. A., Gracey, A. Y., Logue, J., Polley, S., Caddick, M., . . . Maclean, N. (2002). The role of desaturases in cold-induced lipid restructuring. BIOCHEMICAL SOCIETY TRANSACTIONS, 30, 1082-1086 Part 6.

    2001

    The Aspergillus nidulans GATA transcription factor gene areB encodes at least three proteins and features three classes of mutation (Journal article)

    Conlon, H., Zadra, I., Haas, H., Arst, H. N., Jones, M. G., & Caddick, M. X. (2001). The Aspergillus nidulans GATA transcription factor gene areB encodes at least three proteins and features three classes of mutation. Molecular Microbiology, 40(2), 361-375. doi:10.1046/j.1365-2958.2001.02399.x

    DOI: 10.1046/j.1365-2958.2001.02399.x

    Characterization of nitrogen metabolite signalling in Aspergillus via the regulated degradation of areA mRNA (Journal article)

    Morozov, I. Y., Galbis-Martinez, M., Jones, M. G., & Caddick, M. X. (2001). Characterization of nitrogen metabolite signalling in Aspergillus via the regulated degradation of areA mRNA. Mol. Microbiol, 42(1), 269-277.

    Characterization of nitrogen metabolite signalling in Aspergillus via the regulated degradation of areA mRNA (Journal article)

    Morozov, I. Y., Galbis-Martinez, M., Jones, M. G., & Caddick, M. X. (n.d.). Characterization of nitrogen metabolite signalling in Aspergillus via the regulated degradation of areA mRNA. Molecular Microbiology, 42(1), 269-277. doi:10.1046/j.1365-2958.2001.02636.x

    DOI: 10.1046/j.1365-2958.2001.02636.x

    Characterization of the ethanol-inducible alc gene-expression system in Arabidopsis thaliana (Journal article)

    Roslan, H. A., Salter, M. G., Wood, C. D., White, M. R. H., Croft, K. P., Robson, F., . . . Caddick, M. X. (2001). Characterization of the ethanol-inducible alc gene-expression system in Arabidopsis thaliana. Plant Journal, 28(2), 225-235.

    Evaluating low level sequence identities - Are Aspergillus QUTA and AROM homologous? (Journal article)

    Nicholas, H. B., Arst, H. N., & Caddick, M. X. (2001). Evaluating low level sequence identities - Are Aspergillus QUTA and AROM homologous?. European Journal Of Biochemistry, 268(2), 414-419.

    The Aspergillus nidulans GATA transcription factor gene areB encodes at least three proteins and features three classes of mutation (Journal article)

    Conlon, H., Zadra, I., Haas, H., Arst, H. N., Jones, M. G., & Caddick, M. X. (2001). The Aspergillus nidulans GATA transcription factor gene areB encodes at least three proteins and features three classes of mutation. Molecular Microbiology, 40(2), 361-375.

    2000

    Thermal thresholds of lipid restructuring and Delta(9)-desaturase expression in the liver of carp (Cyprinus carpio L.) (Journal article)

    Trueman, R. J., Tiku, P. E., Caddick, M. X., & Cossins, A. R. (2000). Thermal thresholds of lipid restructuring and Delta(9)-desaturase expression in the liver of carp (Cyprinus carpio L.). JOURNAL OF EXPERIMENTAL BIOLOGY, 203(3), 641-650. Retrieved from http://gateway.webofknowledge.com/