Photo of Dr James Hartwell

Dr James Hartwell Ph.D., B.Sc. (Hons)

Senior Lecturer in Plant Metabolism Biochemistry & Systems Biology

Publications

Selected Publications

  1. Engineering crassulacean acid metabolism to improve water-use efficiency (Journal article - 2014)
  2. Parallel Recruitment of Multiple Genes into C-4 Photosynthesis (Journal article - 2013)
  3. Adaptive Evolution of C-4 Photosynthesis through Recurrent Lateral Gene Transfer (Journal article - 2012)
  4. Exploiting the potential of plants with crassulacean acid metabolism for bioenergy production on marginal lands (Journal article - 2009)
  5. Conservation and divergence of circadian clock operation in a stress-inducible crassulacean acid metabolism species reveals clock compensation against stress (Journal article - 2005)

2021

Phosphorolytic degradation of leaf starch via plastidic a-glucan phosphorylase leads to optimised plant growth and water use efficiency over the diel phases of Crassulacean acid metabolism. (Journal article)

Ceusters, N., Ceusters, J., Hurtado-Castano, N., Dever, L. V., Boxall, S. F., Knerová, J., . . . Borland, A. M. (2021). Phosphorolytic degradation of leaf starch via plastidic a-glucan phosphorylase leads to optimised plant growth and water use efficiency over the diel phases of Crassulacean acid metabolism.. Journal of experimental botany. doi:10.1093/jxb/erab132

DOI: 10.1093/jxb/erab132

2020

Developing Portulaca oleracea as a model system for functional genomics analysis of C4/CAM photosynthesis (Journal article)

Callegari Ferrari, R., Pires Bittencourt, P., Yumi Nagumo, P., Silva Oliveira, W., Aurineide Rodrigues, M., Hartwell, J., & Freschi, L. (2020). Developing Portulaca oleracea as a model system for functional genomics analysis of C4/CAM photosynthesis. Functional Plant Biology. doi:10.1071/fp20202

DOI: 10.1071/fp20202

CAM guard cell anion channel activity follows transcript abundance and is suppressed by apoplastic malate. (Journal article)

Lefoulon, C., Boxall, S. F., Hartwell, J., & Blatt, M. R. (2020). Crassulacean acid metabolism guard cell anion channel activity follows transcript abundance and is suppressed by apoplastic malate. NEW PHYTOLOGIST, 227(6), 1847-1857. doi:10.1111/nph.16640

DOI: 10.1111/nph.16640

Exploring C-4-CAM plasticity within the Portulaca oleracea complex (Journal article)

Ferrari, R. C., Cruz, B. C., Gastaldi, V. D., Storl, T., Ferrari, E. C., Boxall, S. F., . . . Freschi, L. (2020). Exploring C-4-CAM plasticity within the Portulaca oleracea complex. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-71012-y

DOI: 10.1038/s41598-020-71012-y

Kalanchoe PPC1 Is Essential for Crassulacean Acid Metabolism and the Regulation of Core Circadian Clock and Guard Cell Signaling Genes([CC-BY]) (Journal article)

Boxall, S. F., Kadu, N., Dever, L. V., Knerova, J., Waller, J. L., Gould, P. J. D., & Hartwell, J. (2020). Kalanchoe PPC1 Is Essential for Crassulacean Acid Metabolism and the Regulation of Core Circadian Clock and Guard Cell Signaling Genes([CC-BY]). The Plant Cell, 32(4), 1136-1160. doi:10.1105/tpc.19.00481

DOI: 10.1105/tpc.19.00481

C4 and crassulacean acid metabolism within a single leaf: deciphering key components behind a rare photosynthetic adaptation. (Journal article)

Ferrari, R. C., Bittencourt, P. P., Rodrigues, M. A., Moreno-Villena, J. J., Alves, F. R. R., Gastaldi, V. D., . . . Freschi, L. (2020). C4 and crassulacean acid metabolism within a single leaf: deciphering key components behind a rare photosynthetic adaptation.. The New Phytologist, 225(4), 1699-1714. doi:10.1111/nph.16265

DOI: 10.1111/nph.16265

2019

Silencing PHOSPHOENOLPYRUVATE CARBOXYLASE1 in the Obligate Crassulacean Acid Metabolism Species Kalanchoë laxiflora causes Reversion to C3-like Metabolism and Amplifies Rhythmicity in a Subset of Core Circadian Clock Genes (Journal article)

Boxall, S., Kadu, N., Dever, L., Knerová, J., Waller, J., Gould, P., & Hartwell, J. (2019). Silencing PHOSPHOENOLPYRUVATE CARBOXYLASE1 in the Obligate Crassulacean Acid Metabolism Species Kalanchoë laxiflora causes Reversion to C3-like Metabolism and Amplifies Rhythmicity in a Subset of Core Circadian Clock Genes. doi:10.1101/684050

DOI: 10.1101/684050

2017

The Kalanchoe genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism (Journal article)

Yang, X., Hu, R., Yin, H., Jenkins, J., Shu, S., Tang, H., . . . Tuskan, G. A. (2017). The Kalanchoe genome provides insights into convergent evolution and building blocks of crassulacean acid metabolism. NATURE COMMUNICATIONS, 8. doi:10.1038/s41467-017-01491-7

DOI: 10.1038/s41467-017-01491-7

Phosphorylation of Phosphoenolpyruvate Carboxylase Is Essential for Maximal and Sustained Dark CO2 Fixation and Core Circadian Clock Operation in the Obligate Crassulacean Acid Metabolism Species Kalanchoe fedtschenkoi (Journal article)

Boxall, S. F., Dever, L. V., Knerova, J., Gould, P. D., & Hartwell, J. (2017). Phosphorylation of Phosphoenolpyruvate Carboxylase Is Essential for Maximal and Sustained Dark CO2 Fixation and Core Circadian Clock Operation in the Obligate Crassulacean Acid Metabolism Species Kalanchoe fedtschenkoi. PLANT CELL, 29(10), 2519-2536. doi:10.1105/tpc.17.00301

DOI: 10.1105/tpc.17.00301

2016

Emerging model systems for functional genomics analysis of Crassulacean acid metabolism (Journal article)

Hartwell, J., Dever, L. V., & Boxall, S. F. (2016). Emerging model systems for functional genomics analysis of Crassulacean acid metabolism. CURRENT OPINION IN PLANT BIOLOGY, 31, 100-108. doi:10.1016/j.pbi.2016.03.019

DOI: 10.1016/j.pbi.2016.03.019

2015

A comparison of high-throughput techniques for assaying circadian rhythms in plants (Journal article)

Tindall, A. J., Waller, J., Greenwood, M., Gould, P. D., Hartwell, J., & Hall, A. (2015). A comparison of high-throughput techniques for assaying circadian rhythms in plants. PLANT METHODS, 11. doi:10.1186/s13007-015-0071-9

DOI: 10.1186/s13007-015-0071-9

A roadmap for research on crassulacean acid metabolism (CAM) to enhance sustainable food and bioenergy production in a hotter, drier world (Journal article)

Yang, X., Cushman, J. C., Borland, A. M., Edwards, E. J., Wullschleger, S. D., Tuskan, G. A., . . . Holtum, J. A. M. (2015). A roadmap for research on crassulacean acid metabolism (CAM) to enhance sustainable food and bioenergy production in a hotter, drier world. NEW PHYTOLOGIST, 207(3), 491-504. doi:10.1111/nph.13393

DOI: 10.1111/nph.13393

Climate-resilient agroforestry: physiological responses to climate change and engineering of crassulacean acid metabolism (CAM) as a mitigation strategy (Journal article)

Borland, A. M., Wullschleger, S. D., Weston, D. J., Hartwell, J., Tuskan, G. A., Yang, X., & Cushman, J. C. (2015). Climate-resilient agroforestry: physiological responses to climate change and engineering of crassulacean acid metabolism (CAM) as a mitigation strategy. PLANT CELL AND ENVIRONMENT, 38(9), 1833-1849. doi:10.1111/pce.12479

DOI: 10.1111/pce.12479

Transgenic perturbation of the decarboxylation phase of Crassulacean acid metabolism alters physiology and metabolism but has only a small effect on growth (Journal article)

Dever, L., Boxall, S., Knerova, J., & Hartwell, J. (2015). Transgenic perturbation of the decarboxylation phase of Crassulacean acid metabolism alters physiology and metabolism but has only a small effect on growth. Plant Physiology, 167(1), 44-59. doi:10.1104/pp.114.251827

DOI: 10.1104/pp.114.251827

2014

Engineering crassulacean acid metabolism to improve water-use efficiency (Journal article)

Borland, A. M., Hartwell, J., Weston, D. J., Schlauch, K. A., Tschaplinski, T. J., Tuskan, G. A., . . . Cushman, J. C. (2014). Engineering crassulacean acid metabolism to improve water-use efficiency. TRENDS IN PLANT SCIENCE, 19(5), 327-338. doi:10.1016/j.tplants.2014.01.006

DOI: 10.1016/j.tplants.2014.01.006

2013

Parallel Recruitment of Multiple Genes into C-4 Photosynthesis (Journal article)

Christin, P. -A., Boxall, S. F., Gregory, R., Edwards, E. J., Hartwell, J., & Osborne, C. P. (2013). Parallel Recruitment of Multiple Genes into C-4 Photosynthesis. GENOME BIOLOGY AND EVOLUTION, 5(11), 2174-2187. doi:10.1093/gbe/evt168

DOI: 10.1093/gbe/evt168

2012

Adaptive Evolution of C-4 Photosynthesis through Recurrent Lateral Gene Transfer (Journal article)

Christin, P. -A., Edwards, E. J., Besnard, G., Boxall, S. F., Gregory, R., Kellogg, E. A., . . . Osborne, C. P. (2012). Adaptive Evolution of C-4 Photosynthesis through Recurrent Lateral Gene Transfer. CURRENT BIOLOGY, 22(5), 445-449. doi:10.1016/j.cub.2012.01.054

DOI: 10.1016/j.cub.2012.01.054

2011

Proteomic and transcriptomic analysis reveals evidence for the basis of salt sensitivity in Thai jasmine rice (Oryza sativa L. cv. KDML 105) (Journal article)

Jankangram, W., Thammasirirak, S., Jones, M. G., Hartwell, J., & Theerakulpisut, P. (2011). Proteomic and transcriptomic analysis reveals evidence for the basis of salt sensitivity in Thai jasmine rice (Oryza sativa L. cv. KDML 105). AFRICAN JOURNAL OF BIOTECHNOLOGY, 10(72), 16157-16166. doi:10.5897/AJB11.1559

DOI: 10.5897/AJB11.1559

2010

The Origins of C-4 Grasslands: Integrating Evolutionary and Ecosystem Science (Journal article)

Edwards, E. J., Osborne, C. P., Stroemberg, C. A. E., Smith, S. A., Bond, W. J., Christin, P. -A., . . . Consortium, C. G. (2010). The Origins of C-4 Grasslands: Integrating Evolutionary and Ecosystem Science. SCIENCE, 328(5978), 587-591. doi:10.1126/science.1177216

DOI: 10.1126/science.1177216

Characterisation of the Circadian Clock in Barley and its Effect on Fitness and Yield (Journal article)

Cotter, S., Hall, A., Hartwell, J., & Salem, R. (2010). Characterisation of the Circadian Clock in Barley and its Effect on Fitness and Yield. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL, 46, S16. Retrieved from http://gateway.webofknowledge.com/

2009

Distinct patterns of control and expression amongst members of the PEP carboxylase kinase gene family in C-4 plants (vol 48, pg 43, 2006) (Journal article)

Shenton, M., Fontaine, V., Hartwell, J., Marsh, J. T., Jenkins, G. I., & Nimmo, H. G. (2009). Distinct patterns of control and expression amongst members of the PEP carboxylase kinase gene family in C-4 plants (vol 48, pg 43, 2006). PLANT JOURNAL, 59(1), 192. doi:10.1111/j.1365-313X.2009.03858.x

DOI: 10.1111/j.1365-313X.2009.03858.x

Exploiting the potential of plants with crassulacean acid metabolism for bioenergy production on marginal lands (Journal article)

Borland, A. M., Griffiths, H., Hartwell, J., & Smith, J. A. C. (2009). Exploiting the potential of plants with crassulacean acid metabolism for bioenergy production on marginal lands. JOURNAL OF EXPERIMENTAL BOTANY, 60(10), 2879-2896. doi:10.1093/jxb/erp118

DOI: 10.1093/jxb/erp118

Delayed fluorescence as a universal tool for the measurement of circadian rhythms in higher plants (Journal article)

Gould, P. D., Diaz, P., Hogben, C., Kusakina, J., Salem, R., Hartwell, J., & Hall, A. (2009). Delayed fluorescence as a universal tool for the measurement of circadian rhythms in higher plants. PLANT JOURNAL, 58(5), 893-901. doi:10.1111/j.1365-313X.2009.03819.x

DOI: 10.1111/j.1365-313X.2009.03819.x

Ecological implications of plants' ability to tell the time (Journal article)

Resco, V., Hartwell, J., & Hall, A. (2009). Ecological implications of plants' ability to tell the time. ECOLOGY LETTERS, 12(6), 583-592. doi:10.1111/j.1461-0248.2009.01295.x

DOI: 10.1111/j.1461-0248.2009.01295.x

2008

Investigating effects of temperature on the circadian clock in plants (Conference Paper)

Kusakina, J., Hartwell, J., & Hall, A. (2008). Investigating effects of temperature on the circadian clock in plants. In COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY Vol. 150 (pp. S154). doi:10.1016/j.cbpa.2008.04.397

DOI: 10.1016/j.cbpa.2008.04.397

Molecular dissection of the circadian clock output pathway that mediates the temporal coordination of Crassulacean acid metabolism (Conference Paper)

Meszter, R., Boxall, S., Jones, M., & Hartwell, J. (2008). Molecular dissection of the circadian clock output pathway that mediates the temporal coordination of Crassulacean acid metabolism. In COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY Vol. 150 (pp. S153). doi:10.1016/j.cbpa.2008.04.394

DOI: 10.1016/j.cbpa.2008.04.394

The critical role of the Arabidopsis circadian clock at high temperature (Thesis / Dissertation)

Costa, N., Hartwell, J., & Hall, A. (2008). The critical role of the Arabidopsis circadian clock at high temperature. Retrieved from http://gateway.webofknowledge.com/

DOI: 10.1016/j.cbpa.2008.04.396

2007

The Circadian Clock in CAM Plants (Chapter)

Hartwell, J. (n.d.). The Circadian Clock in CAM Plants. In Endogenous Plant Rhythms (pp. 211-236). Blackwell Publishing Ltd. doi:10.1002/9780470988527.ch9

DOI: 10.1002/9780470988527.ch9

2006

Distinct patterns of control and expression amongst members of the PEP carboxylase kinase gene family in C-4 plants (Journal article)

Shenton, M., Fontaine, V., Hartwell, J., Marsh, J. T., Jenkins, G. I., & Nimmo, H. G. (2006). Distinct patterns of control and expression amongst members of the PEP carboxylase kinase gene family in C-4 plants. PLANT JOURNAL, 48(1), 45-53. doi:10.1111/j.1365-313X.2006.02850.x

DOI: 10.1111/j.1365-313X.2006.02850.x

Circadian control of isoprene emissions from oil palm (Elaeis guineensis) (Journal article)

Wilkinson, M. J., Owen, S. M., Possell, M., Hartwell, J., Gould, P., Hall, A., . . . Hewitt, C. N. (2006). Circadian control of isoprene emissions from oil palm (Elaeis guineensis). PLANT JOURNAL, 47(6), 960-968. doi:10.1111/j.1365-313X.2006.02847.x

DOI: 10.1111/j.1365-313X.2006.02847.x

2005

Conservation and divergence of circadian clock operation in a stress-inducible crassulacean acid metabolism species reveals clock compensation against stress (Journal article)

Boxall, S. F., Foster, J. M., Bohnert, H. J., Cushman, J. C., Nimmo, H. G., & Hartwell, J. (2005). Conservation and divergence of circadian clock operation in a stress-inducible crassulacean acid metabolism species reveals clock compensation against stress. PLANT PHYSIOLOGY, 137(3), 969-982. doi:10.1104/pp.104.054577

DOI: 10.1104/pp.104.054577

The co-ordination of central plant metabolism by the circadian clock. (Journal article)

Hartwell, J. (2005). The co-ordination of central plant metabolism by the circadian clock.. Biochemical Society transactions, 33(Pt 5), 945-948. doi:10.1042/bst20050945

DOI: 10.1042/bst20050945

2003

Structure and expression of phosphoenolpyruvate carboxylase kinase genes in solanaceae. A novel gene exhibits alternative splicing (Journal article)

Marsh, J. T., Sullivan, S., Hartwell, J., & Nimmo, H. O. (2003). Structure and expression of phosphoenolpyruvate carboxylase kinase genes in solanaceae. A novel gene exhibits alternative splicing. PLANT PHYSIOLOGY, 133(4), 2021-2028. doi:10.1104/pp.103.030775

DOI: 10.1104/pp.103.030775

2002

Probing the circadian control of phosphoenolpyruvate carboxylase kinase expression in Kalanchoe fedtschenkoi (Journal article)

Hartwell, J., Nimmo, G. A., Wilkins, M. B., Jenkins, G. I., & Nimmo, H. G. (2002). Probing the circadian control of phosphoenolpyruvate carboxylase kinase expression in Kalanchoe fedtschenkoi. FUNCTIONAL PLANT BIOLOGY, 29(6), 663-668. doi:10.1071/PP01208

DOI: 10.1071/PP01208

Arabidopsis thaliana contains two phosphoenolpyruvate carboxylase kinase genes with different expression patterns (Journal article)

Fontaine, V., Hartwell, J., Jenkins, G. I., & Nimmo, H. G. (2002). Arabidopsis thaliana contains two phosphoenolpyruvate carboxylase kinase genes with different expression patterns. PLANT CELL AND ENVIRONMENT, 25(1), 115-122. doi:10.1046/j.0016-8025.2001.00805.x

DOI: 10.1046/j.0016-8025.2001.00805.x

2001

PEP carboxylase kinase is a novel protein kinase controlled at the level of expression (Journal article)

Nimmo, H. G., Fontaine, V., Hartwell, J., Jenkins, G. I., Nimmo, G. A., & Wilkins, M. B. (2001). PEP carboxylase kinase is a novel protein kinase controlled at the level of expression. NEW PHYTOLOGIST, 151(1), 91-97. doi:10.1046/j.1469-8137.2001.00155.x

DOI: 10.1046/j.1469-8137.2001.00155.x

1999

Metabolite control overrides circadian regulation of phosphoenolpyruvate carboxylase kinase and CO2 fixation in Crassulacean acid metabolism (Journal article)

Borland, A. M., Hartwell, J., Jenkins, G. I., Wilkins, M. B., & Nimmo, H. G. (1999). Metabolite control overrides circadian regulation of phosphoenolpyruvate carboxylase kinase and CO2 fixation in Crassulacean acid metabolism. PLANT PHYSIOLOGY, 121(3), 889-896. doi:10.1104/pp.121.3.889

DOI: 10.1104/pp.121.3.889

Phosphoenolpyruvate carboxylase kinase is a novel protein kinase regulated at the level of expression (Journal article)

Hartwell, J., Gill, A., Nimmo, G. A., Wilkins, M. B., Jenkins, G. I., & Nimmo, H. G. (1999). Phosphoenolpyruvate carboxylase kinase is a novel protein kinase regulated at the level of expression. The Plant Journal, 20(3), 333-342. doi:10.1046/j.1365-313x.1999.00609.x

DOI: 10.1046/j.1365-313x.1999.00609.x

Phosphoenolpyruvate carboxylase kinase is a novel protein kinase regulated at the level of expression (Journal article)

Hartwell, J., Gill, A., Nimmo, G. A., Wilkins, M. B., Jenkins, G. L., & Nimmo, H. G. (1999). Phosphoenolpyruvate carboxylase kinase is a novel protein kinase regulated at the level of expression. PLANT JOURNAL, 20(3), 333-342. doi:10.1046/j.1365-313X.1999.t01-1-00609.x

DOI: 10.1046/j.1365-313X.1999.t01-1-00609.x

The light induction of maize phosphoenolpyruvate carboxylase kinase translatable mRNA requires transcription but not translation (Journal article)

Hartwell, J., Jenkins, G. I., Wilkins, M. B., & Nimmo, H. G. (1999). The light induction of maize phosphoenolpyruvate carboxylase kinase translatable mRNA requires transcription but not translation. PLANT CELL AND ENVIRONMENT, 22(7), 883-889. doi:10.1046/j.1365-3040.1999.00455.x

DOI: 10.1046/j.1365-3040.1999.00455.x

1996

Higher plant phosphoenolpyruvate carboxylase kinase is regulated at the level of translatable mRNA in response to light or a circadian rhythm (Journal article)

Hartwell, J., Smith, L. H., Wilkins, M. B., Jenkins, G. I., & Nimmo, H. G. (1996). Higher plant phosphoenolpyruvate carboxylase kinase is regulated at the level of translatable mRNA in response to light or a circadian rhythm. PLANT JOURNAL, 10(6), 1071-1078. doi:10.1046/j.1365-313X.1996.10061071.x

DOI: 10.1046/j.1365-313X.1996.10061071.x

Recycling of carbon in the oxidative pentose phosphate pathway in non-photosynthetic plastids (Journal article)

Hartwell, J., Bowsher, C. G., & Emes, M. J. (1996). Recycling of carbon in the oxidative pentose phosphate pathway in non-photosynthetic plastids. PLANTA, 200(1), 107-112. Retrieved from http://gateway.webofknowledge.com/

1995

Molecular phylogenetics of Lilianae (Chapter)

Chase, M. W., Duvall, M. R., Hills, H. G., Conran, J. G., Cox, A. V., Eguiarte, L. E., . . . Hoot, S. (1995). Molecular phylogenetics of Lilianae. In P. J. Rudall, P. J. Cribb, D. F. Cutler, & C. J. Humphries (Eds.), Monocotyledons: systematics and evolution (pp. 109-137). London, UK: Royal Botanics Gardens, Kew.

Undated

Functional genomics of Crassulacean acid metabolism in the monocot biomass feedstock crop Agave sisalana (Thesis / Dissertation)

Bupphada, P. (n.d.). Functional genomics of Crassulacean acid metabolism in the monocot biomass feedstock crop Agave sisalana. (PhD Thesis, University of Liverpool).