Photo of Dr Ed Yates

Dr Ed Yates BSc(hons) PGCert, PhD, MRSC, FHEA, FRSC

Lecturer Biochemistry & Systems Biology

    Research

    Research Interest 1

    Glycosaminoglycan structure function relationships.
    Protein-sugar interactions and spectroscopic methods for their study.
    Carbohydrate chemistry.
    Microbial-sugar interactions and their inhibition.

    Research Grants

    An enzymatic approach to the understanding, design and formation of novel polysaccharides with potential industrial applications

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2018 - January 2019

    Improved functional materials for wound dressings from seaweeds

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    August 2018 - January 2019

    Analysis of Mucin Interactions

    UNILEVER PLC (UK)

    October 2017 - December 2017

    Identification and evaluation of algal sulphatransferases for enzymatic polysaccharide modifications

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2017 - December 2017

    Investigating the potential of non-heparin anticoagulant agents with antithrombin.

    WELLCOME TRUST (UK)

    June 2016 - July 2016

    3-O-sulfated heparan sulfate translocation in altered membrane biology: A new strategy for early population screening and halting Alzheimer’s neurodegeneration (ArrestAD)

    EUROPEAN COMMISSION

    January 2017 - May 2022

    Generation of oligosaccharides from branched marine glycosaminoglycan – fucosylated chondroitin sulfate

    IBCARB (UK)

    September 2015 - November 2015

    Polysaccharide analysis

    SHANDONG CHENZHONG BIOPHARMACEUTICAL CO LTD (CHINA)

    November 2016 - March 2017

    Characterisation of polysaccharides derived from seaweeds, along with a preliminary assessment of their potential for development of nutriceutical, healthcare and functional food and beverage products.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2015 - December 2015

    New tools and resources to evaluate biological sulphation

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    October 2016 - March 2018

    Bench Fees Ahmed Alzahrani

    MINISTRY OF HEALTH (SAUDI ARABIA)

    September 2015 - August 2016

    Exploiting saccharide microarrays: towards glycomic studies of heparan sulphate-protein interactions.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    February 2004 - January 2007

    Novel semi-synthetic carbohydrates as potential therapeutics for severe malaria.

    MEDICAL RESEARCH COUNCIL (MRC)

    March 2008 - August 2012

    Carbohydrate isoelectric focusing: A new tool for the unprecedented separation of complex glycosaminoglycan structures.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    October 2008 - September 2009

    Spectroscopic Analysis of Protein-Polysaccharide Complexes

    DIAMOND LIGHT SOURCE LTD (UK)

    October 2010 - September 2014

    Chemical intervention in heparan sulphate-dependent growth factor signalling systems using engineered heparin saccharides.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    February 2006 - March 2009

    CIC biomaGUNE studentship

    CIC BIOMAGUNE (SPAIN)

    January 2012 - December 2015

    Spectroscopic tools for improved protein secondary structure analysis in protein-heparan sulfate complexes

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2006 - October 2007

    Interaction of heparan sulfate with the protease beta-secretase: a novel mechanism for regulation of APP processing.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    July 2004 - December 2007

    Chemically modified low molecular weight heparins as potent disruptors of rosetting in severe malaria

    WELLCOME TRUST (UK)

    October 2010 - September 2011

    Molecular function in post-genome biology (MOLFUN).

    EUROPEAN COMMISSION

    October 2006 - September 2010

    Highly sensitive, rapid and high throughput sequecen analysis of glycosaminoglycans

    WELLCOME TRUST (UK)

    August 2007 - January 2010

    Evaluation of optimised heparins as novel therapeutics for alzheimers disease.

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    May 2006 - August 2007

    University of Liverpool Institutional Discipline Bridging.

    MEDICAL RESEARCH COUNCIL (MRC)

    October 2003 - October 2006

    Structures of signalling and inhibitory complexes

    ROYAL SOCIETY (CHARITABLE)

    April 2008 - March 2010

    CASE: Detecting structural changes in protein:polysaccharide complexes: an enabling technology

    M I ENGINEERING (UK)

    January 2011 - December 2014

    Compatibility rules for glycosaminoglycan-amyloid interactions

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    May 2014 - April 2017

    Research Collaborations

    Marcelo Lima and Helena Nader

    External: University of São Paulo

    Dr Robert Lauder

    External: The University of Lancaster

    to conduct solution conformation and spectroscopic studies of macromolecules

    DR J Shute

    External: The University of Portsmouth

    exploring the potential of modified heparin polysaccharides to promote DNase activity in cystic fibrosis patients

    Dr J Smalley

    Internal

    analysis of LPS carbohydrates

    Prof R Nichols

    Internal

    spectroscopic investigations of protein sugar interactions

    Dr M Horsburgh

    Internal

    carbohydrate interactions with Staph aureus bacteria and role in adhesion and infection

    Drs M Guerrini, A.Naggi and G.Torri

    External: Ronzoni Institute for Chemical and Biochemical Research, Milan

    NMR structural studies of poly- and oligosaccharides and their conformation and interactions with cations

    Dr M Goldner

    External: University of Laval, Quebec

    Relationship between environmental conditions and attachment of B fragilis to ECM components

    Prof DG Fernig

    Internal

    spectroscopic studies of protein-sugar interactions

    nanoparticles

    Dr EO Ferreira and Prof R Domingues

    External: Federal University of Rio de Janeiro (UFRJ)

    Investigating the interaction of anaerobic pathogenic bacteria (esp B fragilis, C dificile) with components of the host extracellular matrix and the effect of environmental pH and Eh