Dr Ed Yates BSc(hons) PGCert, PhD, MRSC, FHEA, FRSC

Lecturer Biochemistry, Cell and Systems Biology

+44 (0)151 795 4429
Work email E.A.Yates@liverpool.ac.uk

Publications

Filter the publication list

Filter list by type

Show all
Journal article
Conference paper
Chapter
Other

2023

Convenient syntheses of trans-resveratrol 3-O and 4′-O-β-<scp>d</scp>-glucuronides and a study of their aqueous stability (Journal article)

Fraser, M. K., Gorecka, A., Yates, E. A., Iggo, J. A., Baj, K., & Stachulski, A. V. (2023). Convenient syntheses of trans-resveratrol 3-O and 4′-O-β-<scp>d</scp>-glucuronides and a study of their aqueous stability. Organic Chemistry Frontiers. doi:10.1039/d3qo01736b

DOI: 10.1039/d3qo01736b

History and Prospects for the Sustainability and Circularity of the Windowpane Oyster Placuna placenta Fishery in the Philippines (Journal article)

Rustia, J. M., Antonino, J. P., Velasco, R. R., Lima, M. A., Yates, E. A., & Fernig, D. G. (2023). History and Prospects for the Sustainability and Circularity of the Windowpane Oyster Placuna placenta Fishery in the Philippines. Fishes, 8(10), 493. doi:10.3390/fishes8100493

DOI: 10.3390/fishes8100493

Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells. (Journal article)

Pagani, I., Ottoboni, L., Panina-Bordignon, P., Martino, G., Poli, G., Taylor, S., . . . Vicenzi, E. (2023). Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells.. Pharmaceuticals (Basel, Switzerland), 16(10), 1385. doi:10.3390/ph16101385

DOI: 10.3390/ph16101385

History and Prospects for Sustainability and Circularity of the Windowpane Oyster Placuna placenta Fishery in the Philippines (Preprint)

DOI: 10.20944/preprints202308.2168.v1

Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination (Journal article)

Lindsay, S. L., McCanney, G. A., Zhan, J., Scheld, M., Smith, R. S., Goodyear, C. S., . . . Barnett, S. C. (2023). Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination. GLIA. doi:10.1002/glia.24363

DOI: 10.1002/glia.24363

Heparin in Acid and Alkaline Environments—A Study of the Correlations between Hydrodynamic Properties and Desulphation (Journal article)

Kozlowski, A. M., Dinu, V., MacCalman, T., Smith, A. M., Roubroeks, J. P., Yates, E. A., . . . Morris, G. A. (n.d.). Heparin in Acid and Alkaline Environments—A Study of the Correlations between Hydrodynamic Properties and Desulphation. Polysaccharides, 4(2), 88-98. doi:10.3390/polysaccharides4020007

DOI: 10.3390/polysaccharides4020007

Monitoring the stability of heparin: NMR evidence for the rearrangement of sulfated iduronate in phosphate buffer (Journal article)

Kozlowski, A. M., Yates, E. A., Roubroeks, J. P., Tommeraas, K., Larsen, F. H., Smith, A. M., & Morris, G. A. (2023). Monitoring the stability of heparin: NMR evidence for the rearrangement of sulfated iduronate in phosphate buffer. CARBOHYDRATE POLYMERS, 308. doi:10.1016/j.carbpol.2023.120649

DOI: 10.1016/j.carbpol.2023.120649

Functions and specificity of bacterial carbohydrate sulfatases targeting host glycans (Journal article)

Luis, A. S., Yates, E. A., & Cartmell, A. (2023). Functions and specificity of bacterial carbohydrate sulfatases targeting host glycans. ESSAYS IN BIOCHEMISTRY, 67(3), 429-442. doi:10.1042/EBC20220120

DOI: 10.1042/EBC20220120

Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State (Journal article)

Devlin, A. J., Mycroft-West, C. J., Turnbull, J. E., de Lima, M. A., Guerrini, M., Yates, E. A., & Skidmore, M. A. (2023). Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State. ACS CENTRAL SCIENCE, 9(3), 381-392. doi:10.1021/acscentsci.2c01176

DOI: 10.1021/acscentsci.2c01176

High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts (Journal article)

Maciej-Hulme, M. L., Leprince, A. C. N., Lavin, A., Guimond, S. E., Turnbull, J. E., Pelletier, J., . . . Skidmore, M. A. (2023). High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. ANALYTICAL METHODS, 15(11), 1461-1469. doi:10.1039/d2ay01803a

DOI: 10.1039/d2ay01803a

Validation of Recombinant Heparan Sulphate Reagents for CNS Repair (Journal article)

Lindsay, S. L. L., Smith, R. S., Yates, E. A. A., Cartwright, C., Thacker, B. E. E., Turnbull, J. E. E., . . . Barnett, S. C. C. (2023). Validation of Recombinant Heparan Sulphate Reagents for CNS Repair. BIOLOGY-BASEL, 12(3). doi:10.3390/biology12030407

DOI: 10.3390/biology12030407

A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease 0-site amyloid precursor protein cleaving enzyme 1 (BACE-1) (Journal article)

Mycroft-West, C. J., Devlin, A. J., Cooper, L. C., Guimond, S. E., Procter, P., Miller, G. J., . . . Skidmore, M. A. (2023). A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease 0-site amyloid precursor protein cleaving enzyme 1 (BACE-1). CARBOHYDRATE RESEARCH, 525. doi:10.1016/j.carres.2023.108747

DOI: 10.1016/j.carres.2023.108747

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors (Journal article)

Gray, A. L., Karlsson, R., Roberts, A. R. E., Ridley, A. J. L., Pun, N., Khan, B., . . . Dyer, D. P. (2023). Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors. CELL REPORTS, 42(1). doi:10.1016/j.celrep.2022.111930

DOI: 10.1016/j.celrep.2022.111930

Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans (Journal article)

Parafioriti, M., Ni, M., Petitou, M., Mycroft-West, C. J., Rudd, T. R., Gandhi, N. S., . . . Elli, S. (2023). Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans. CHEMISTRY-A EUROPEAN JOURNAL, 29(1). doi:10.1002/chem.202202599

DOI: 10.1002/chem.202202599

2022

Heparin Protects Human Neural Progenitor Cells from Zika Virus-Induced Cell Death While Preserving Their Differentiation into Mature Neuroglial Cells (Journal article)

Pagani, I., Ottoboni, L., Podini, P., Ghezzi, S., Brambilla, E., Bezukladova, S., . . . Vicenzi, E. (2022). Heparin Protects Human Neural Progenitor Cells from Zika Virus-Induced Cell Death While Preserving Their Differentiation into Mature Neuroglial Cells. JOURNAL OF VIROLOGY, 96(19). doi:10.1128/jvi.01122-22

DOI: 10.1128/jvi.01122-22

Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota (vol 18, pg 841, 2022) (Journal article)

Luis, A. S., Basle, A., Byrne, D. P., Wright, G. S. A., London, J. A., Jin, C., . . . Cartmell, A. (2022). Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota (vol 18, pg 841, 2022). NATURE CHEMICAL BIOLOGY, 18(9), 1032. doi:10.1038/s41589-022-01132-1

DOI: 10.1038/s41589-022-01132-1

Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans (Preprint)

DOI: 10.26434/chemrxiv-2022-21brb-v2

Phosphorylation and sulfation share a common biosynthetic pathway, but extend biochemical and evolutionary diversity of biological macromolecules in distinct ways (Journal article)

Lima, M. A., Rudd, T. R., Fernig, D. G., & Yates, E. A. (2022). Phosphorylation and sulfation share a common biosynthetic pathway, but extend biochemical and evolutionary diversity of biological macromolecules in distinct ways. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 19(193). doi:10.1098/rsif.2022.0391

DOI: 10.1098/rsif.2022.0391

Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota (Journal article)

Luis, A. S., Basle, A., Byrne, D. P., Wright, G. S. A., London, J. A., Jin, C., . . . Cartmell, A. (2022). Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota. NATURE CHEMICAL BIOLOGY, 18(8), 841-+. doi:10.1038/s41589-022-01039-x

DOI: 10.1038/s41589-022-01039-x

Using NMR to Dissect the Chemical Space and O-Sulfation Effects within the O- and S-Glycoside Analogues of Heparan Sulfate (Journal article)

Meneghetti, M. C. Z., Naughton, L., O'Shea, C., Teki, D. S. E. K., Chagnault, V., Nader, H. B., . . . Lima, M. A. (2022). Using NMR to Dissect the Chemical Space and O-Sulfation Effects within the O- and S-Glycoside Analogues of Heparan Sulfate. ACS OMEGA. doi:10.1021/acsomega.2c02070

DOI: 10.1021/acsomega.2c02070

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread non-receptor mediated immune cell recruitment (Preprint)

DOI: 10.1101/2022.07.10.499282

Pentosan Polysulfate Inhibits Attachment and Infection by SARS-CoV-2 In Vitro: Insights into Structural Requirements for Binding (Journal article)

Bertini, S., Alekseeva, A., Elli, S., Pagani, I., Zanzoni, S., Eisele, G., . . . Guerrini, M. (2022). Pentosan Polysulfate Inhibits Attachment and Infection by SARS-CoV-2 In Vitro: Insights into Structural Requirements for Binding. THROMBOSIS AND HAEMOSTASIS, 122(06), 984-997. doi:10.1055/a-1807-0168

DOI: 10.1055/a-1807-0168

NMR spectroscopy and chemometric models to detect a specific non-porcine ruminant contaminant in pharmaceutical heparin. (Journal article)

Colombo, E., Mauri, L., Marinozzi, M., Rudd, T. R., Yates, E. A., Ballabio, D., & Guerrini, M. (2022). NMR spectroscopy and chemometric models to detect a specific non-porcine ruminant contaminant in pharmaceutical heparin.. Journal of pharmaceutical and biomedical analysis, 214, 114724. doi:10.1016/j.jpba.2022.114724

DOI: 10.1016/j.jpba.2022.114724

Initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans involves multiple binding modes (Preprint)

DOI: 10.26434/chemrxiv-2022-21brb

Analysis of protein-heparin interactions using a portable SPR instrument (Journal article)

Su, D., Li, Y., Yates, E. A., Skidmore, M. A., Lima, M. A., & Fernig, D. G. (n.d.). Analysis of protein-heparin interactions using a portable SPR instrument. PeerJ Analytical Chemistry, 4, e15. doi:10.7717/peerj-achem.15

DOI: 10.7717/peerj-achem.15

Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars (Journal article)

London, J. A., Taylor, S. L., Barsukov, I., Cartmell, A., & Yates, E. A. (2022). Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars. RSC ADVANCES, 12(18), 11075-11083. doi:10.1039/d2ra01463g

DOI: 10.1039/d2ra01463g

Structural variation in the linkage region of pharmaceutical heparin arising from oxidative treatments during manufacture. (Journal article)

Urso, E., Mantione, G., Sala, F., Yates, E. A., Guerrini, M., & Naggi, A. (2022). Structural variation in the linkage region of pharmaceutical heparin arising from oxidative treatments during manufacture.. Carbohydrate research, 514, 108540. doi:10.1016/j.carres.2022.108540

DOI: 10.1016/j.carres.2022.108540

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction (Journal article)

Guimond, S. E., Mycroft-West, C. J., Gandhi, N. S., Tree, J. A., Le, T. T., Spalluto, C. M., . . . Turnbull, J. E. (2022). Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction. ACS Central Science. doi:10.1021/acscentsci.1c01293

DOI: 10.1021/acscentsci.1c01293

Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars (Preprint)

DOI: 10.26434/chemrxiv-2022-94rpt

2021

Pentosan polysulfate inhibits attachment and infection by SARS-CoV-2 in vitro: insights into structural requirements for binding (Preprint)

DOI: 10.1101/2021.12.19.473359

Anion binding to a cationic europium(iii) probe enables the first real-time assay of heparan sulfotransferase activity (Journal article)

Wheeler, S., Breen, C., Li, Y., Hewitt, S. H., Robertson, E., Yates, E. A., . . . Butler, S. J. (2021). Anion binding to a cationic europium(iii) probe enables the first real-time assay of heparan sulfotransferase activity. ORGANIC & BIOMOLECULAR CHEMISTRY, 20(3), 596-605. doi:10.1039/d1ob02071d

DOI: 10.1039/d1ob02071d

Glycation of Host Proteins Increases Pathogenic Potential of Porphyromonas gingivalis (Journal article)

Smiga, M., Smalley, J. W., Slezak, P., Brown, J. L., Sieminska, K., Jenkins, R. E., . . . Olczak, T. (2021). Glycation of Host Proteins Increases Pathogenic Potential of Porphyromonas gingivalis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22(21). doi:10.3390/ijms222112084

DOI: 10.3390/ijms222112084

A single sulfatase is required to access colonic mucin by a gut bacterium (Journal article)

Luis, A. S., Jin, C., Pereira, G. V., Glowacki, R. W. P., Gugel, S. R., Singh, S., . . . Martens, E. C. (2021). A single sulfatase is required to access colonic mucin by a gut bacterium. NATURE, 598(7880), 332-+. doi:10.1038/s41586-021-03967-5

DOI: 10.1038/s41586-021-03967-5

Chemical Modification of Glycosaminoglycan Polysaccharides (Journal article)

Palhares, L. C. G. F., London, J. A., Kozlowski, A. M., Esposito, E., Chavante, S. F., Ni, M., & Yates, E. A. (2021). Chemical Modification of Glycosaminoglycan Polysaccharides. MOLECULES, 26(17). doi:10.3390/molecules26175211

DOI: 10.3390/molecules26175211

Endocytosis and the Participation of Glycosaminoglycans Are Important to the Mechanism of Cell Death Induced by β-Hairpin Antimicrobial Peptides (Journal article)

Buri, M. V., Sperandio, L. P., de Souza, K. F. S., Antunes, F., Rezende, M. M., Melo, C. M., . . . Paredes-Gamero, E. J. (2021). Endocytosis and the Participation of Glycosaminoglycans Are Important to the Mechanism of Cell Death Induced by β-Hairpin Antimicrobial Peptides. ACS APPLIED BIO MATERIALS, 4(8), 6488-6501. doi:10.1021/acsabm.1c00390

DOI: 10.1021/acsabm.1c00390

Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota (Preprint)

DOI: 10.21203/rs.3.rs-744774/v1

Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota (Preprint)

DOI: 10.1101/2021.07.23.453482

Heparin protects human neural progenitor cells from Zika Virus-induced cell death and preserves their differentiation into mature neural-glia cells (Preprint)

DOI: 10.1101/2021.05.05.442746

Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer's Disease β Secretase, BACE1 (Journal article)

Mycroft-West, C. J., Devlin, A. J., Cooper, L. C., Guimond, S. E., Procter, P., Guerrini, M., . . . Skidmore, M. A. (2021). Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer's Disease β Secretase, BACE1. MARINE DRUGS, 19(4). doi:10.3390/md19040203

DOI: 10.3390/md19040203

ER-Golgi dynamics of HS-modifying enzymes via vesicular trafficking is a critical prerequisite for the delineation of HS biosynthesis (Journal article)

Meneghetti, M. C. Z., Deboni, P., Palomino, C. M. V., Braga, L. P., Cavalheiro, R. P., Viana, G. M., . . . Lima, M. A. (2021). ER-Golgi dynamics of HS-modifying enzymes via vesicular trafficking is a critical prerequisite for the delineation of HS biosynthesis. CARBOHYDRATE POLYMERS, 255. doi:10.1016/j.carbpol.2020.117477

DOI: 10.1016/j.carbpol.2020.117477

Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity (Journal article)

Byrne, D. P., London, J. A., Eyers, P. A., Yates, E. A., & Cartmell, A. (2021). Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity. BIOCHEMICAL JOURNAL, 478(4), 735-748. doi:10.1042/BCJ20200952

DOI: 10.1042/BCJ20200952

Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity (vol 478, pg 735, 2021) (Journal article)

Byrne, D. P., London, J. A., Eyers, P. A., Yates, E. A., & Cartmell, A. (2021). Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity (vol 478, pg 735, 2021). BIOCHEMICAL JOURNAL, 478(1), 2537-2538. doi:10.1042/BCJ20200952_COR

DOI: 10.1042/BCJ20200952_COR

Hydrolytic Degradation of Heparin in Acidic Environments: Nuclear Magnetic Resonance Reveals Details of Selective Desulfation (Journal article)

Kozlowski, A. M., Yates, E. A., Roubroeks, J. P., Tommeraas, K., Smith, A. M., & Morris, G. A. (2021). Hydrolytic Degradation of Heparin in Acidic Environments: Nuclear Magnetic Resonance Reveals Details of Selective Desulfation. ACS APPLIED MATERIALS & INTERFACES, 13(4), 5551-5563. doi:10.1021/acsami.0c20198

DOI: 10.1021/acsami.0c20198

Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations (Journal article)

Tree, J. A., Turnbull, J. E., Buttigieg, K. R., Elmore, M. J., Coombes, N., Hogwood, J., . . . Carroll, M. W. (2021). Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations. BRITISH JOURNAL OF PHARMACOLOGY, 178(3), 626-635. doi:10.1111/bph.15304

DOI: 10.1111/bph.15304

A single bacterial sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium (Preprint)

DOI: 10.21203/rs.3.rs-113032/v1

A Review of the Distribution, Botany, Phytochemistry and Biological Activity of Dioscorine From Dioscorea hispida (Journal article)

Castillo, D. E., Fernig, D. G., Yates, E. A., & Payonga, A. P. (2021). A Review of the Distribution, Botany, Phytochemistry and Biological Activity of Dioscorine From Dioscorea hispida. PHILIPPINE JOURNAL OF CROP SCIENCE, 46(2). Retrieved from https://www.webofscience.com/

Synthesis and toxicity profile in 293 human embryonic kidney cells of the β D-glucuronide derivatives of ortho-, meta- and para-cresol (Journal article)

London, J. A., Wang, E. C. S., Barsukov, I. L., Yates, E. A., & Stachulski, A. V. (2021). Synthesis and toxicity profile in 293 human embryonic kidney cells of the β D-glucuronide derivatives of ortho-, meta- and para-cresol. CARBOHYDRATE RESEARCH, 499. doi:10.1016/j.carres.2020.108225

DOI: 10.1016/j.carres.2020.108225

2020

Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway (Journal article)

Wang, Z., Cheng, Z. -X., Abrams, S. T., Lin, Z. -Q., Yates, E. D., Yu, Q., . . . Wang, G. -Z. (2020). Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway. WORLD JOURNAL OF GASTROENTEROLOGY, 26(47), 7513-7527. doi:10.3748/wjg.v26.i47.7513

DOI: 10.3748/wjg.v26.i47.7513

Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity (Journal article)

Byrne, D., London, J., Eyers, P., Yates, E., & Cartmell, A. (2020). Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity. doi:10.1101/2020.12.01.406876

DOI: 10.1101/2020.12.01.406876

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin (Journal article)

Mycroft-West, C. J., Su, D., Pagani, I., Rudd, T. R., Elli, S., Gandhi, N. S., . . . Skidmore, M. A. (2020). Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin. THROMBOSIS AND HAEMOSTASIS, 120(12), 1700-1715. doi:10.1055/s-0040-1721319

DOI: 10.1055/s-0040-1721319

A single bacterial sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium (Preprint)

DOI: 10.1101/2020.11.20.392076

Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin (Journal article)

Townsend, D., Fullwood, N. J., Yates, E. A., & Middleton, D. A. (2020). Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin. BIOCHEMISTRY, 59(41), 4003-4014. doi:10.1021/acs.biochem.0c00443

DOI: 10.1021/acs.biochem.0c00443

Should We Be Worried About Clostridioides difficile During the SARS-CoV2 Pandemic? (Journal article)

Ferreira, E. D. O., Penna, B., & Yates, E. A. (2020). Should We Be Worried About Clostridioides difficile During the SARS-CoV2 Pandemic?. FRONTIERS IN MICROBIOLOGY, 11. doi:10.3389/fmicb.2020.581343

DOI: 10.3389/fmicb.2020.581343

Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway (Preprint)

DOI: 10.1101/2020.09.17.302240

Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (vol 11, 646, 2020) (Journal article)

Ndeh, D., Basle, A., Strahl, H., Yates, E. A., McClurgg, U. L., Henrissat, B., . . . Cartmell, A. (2020). Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (vol 11, 646, 2020). NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-18097-1

DOI: 10.1038/s41467-020-18097-1

Unfractionated heparin inhibits live wild-type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations. (Preprint)

DOI: 10.22541/au.159526747.71750127

Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain (Journal article)

Mycroft-West, C., Su, D., Li, Y., Guimond, S., Rudd, T., Elli, S., . . . Skidmore, M. (2020). Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain. doi:10.1101/2020.04.29.068767

DOI: 10.1101/2020.04.29.068767

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins (Journal article)

Mycroft-West, C., Su, D., Li, Y., Guimond, S., Rudd, T., Elli, S., . . . Skidmore, M. (2020). SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins. doi:10.1101/2020.04.29.068486

DOI: 10.1101/2020.04.29.068486

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin (Journal article)

Mycroft-West, C., Su, D., Pagani, I., Rudd, T., Elli, S., Guimond, S., . . . Skidmore, M. (2020). Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin. doi:10.1101/2020.04.28.066761

DOI: 10.1101/2020.04.28.066761

Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure (Journal article)

Sindrewicz, P., Yates, E. A., Turnbull, J. E., Lian, L. -Y., & Yu, L. -G. (2020). Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 523(2), 336-341. doi:10.1016/j.bbrc.2019.12.054

DOI: 10.1016/j.bbrc.2019.12.054

The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding (Journal article)

Mycroft-West, C., Su, D., Elli, S., Li, Y., Li, Y., Guimond, S., . . . Skidmore, M. (2020). The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding. doi:10.1101/2020.02.29.971093

DOI: 10.1101/2020.02.29.971093

Editorial: Heparan Sulfate Proteoglycans and Their Endogenous Modifying Enzymes: Cancer Players, Biomarkers and Therapeutic Targets (Journal article)

Lanzi, C., Yates, E. A., & Cassinelli, G. (2020). Editorial: Heparan Sulfate Proteoglycans and Their Endogenous Modifying Enzymes: Cancer Players, Biomarkers and Therapeutic Targets. FRONTIERS IN ONCOLOGY, 10. doi:10.3389/fonc.2020.00195

DOI: 10.3389/fonc.2020.00195

Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (Journal article)

Ndeh, D., Baslé, A., Strahl, H., Yates, E. A., McClurgg, U. L., Henrissat, B., . . . Cartmell, A. (2020). Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus. Nature Communications, 11. doi:10.1038/s41467-020-14509-4

DOI: 10.1038/s41467-020-14509-4

Heparan sulfate structure is influenced by the ER-Golgi dynamics of its modifying enzymes (Preprint)

DOI: 10.1101/2020.01.23.916940

High sensitivity (zeptomole) detection of BODIPY heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts (Journal article)

Maciej-Hulme, M., Leprince, A., Lavin, A., Guimond, S., Turnbull, J., Pelletier, J., . . . Skidmore, M. A. (2020). High sensitivity (zeptomole) detection of BODIPY heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts. doi:10.1101/2020.01.21.913954

DOI: 10.1101/2020.01.21.913954

SimpleDSFviewer: A tool to analyze and view differential scanning fluorimetry data for characterizing protein thermal stability and interactions (Journal article)

Sun, C., Li, Y., Yates, E. A., & Fernig, D. G. (2020). SimpleDSFviewer: A tool to analyze and view differential scanning fluorimetry data for characterizing protein thermal stability and interactions. PROTEIN SCIENCE, 29(1), 19-27. doi:10.1002/pro.3703

DOI: 10.1002/pro.3703

2019

A further unique chondroitin sulfate from the shrimp Litopenaeus vannamei with antithrombin activity that modulates acute inflammation (Journal article)

Palhares, L. C. G. F., Brito, A. S., de Lima, M. A., Nader, H. B., London, J. A., Barsukov, I. L., . . . Chavante, S. F. (2019). A further unique chondroitin sulfate from the shrimp Litopenaeus vannamei with antithrombin activity that modulates acute inflammation. CARBOHYDRATE POLYMERS, 222. doi:10.1016/j.carbpol.2019.115031

DOI: 10.1016/j.carbpol.2019.115031

Tools for the Quality Control of Pharmaceutical Heparin (Journal article)

Devlin, A., Mycroft-West, C., Procter, P., Cooper, L., Guimond, S., Lima, M., . . . Skidmore, M. (2019). Tools for the Quality Control of Pharmaceutical Heparin. MEDICINA-LITHUANIA, 55(10). doi:10.3390/medicina55100636

DOI: 10.3390/medicina55100636

The use of ATR-FTIR spectroscopy to characterise crude heparin samples by composition and structural features (Preprint)

DOI: 10.1101/744532

Multivariate analysis applied to complex biological medicines (Journal article)

Rudd, T. R., Mauri, L., Marinozzi, M., Stancanelli, E., Yates, E. A., Naggi, A., & Guerrini, M. (2019). Multivariate analysis applied to complex biological medicines. FARADAY DISCUSSIONS, 218, 303-316. doi:10.1039/c9fd00009g

DOI: 10.1039/c9fd00009g

Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions (Journal article)

Sindrewicz, P., Li, X., Yates, E. A., Turnbull, J. E., Lian, L. -Y., & Yu, L. -G. (2019). Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-47658-8

DOI: 10.1038/s41598-019-47658-8

Sulfated polysaccharides interact with fibroblast growth factors and protect from denaturation (Journal article)

Sun, C., Liu, M., Sun, P., Yang, M., Yates, E. A., Guo, Z., & Fernig, D. G. (2019). Sulfated polysaccharides interact with fibroblast growth factors and protect from denaturation. FEBS OPEN BIO, 9(8), 1477-1487. doi:10.1002/2211-5463.12696

DOI: 10.1002/2211-5463.12696

A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease (Journal article)

Mycroft-West, C. J., Cooper, L. C., Devlin, A. J., Procter, P., Guimond, S. E., Guerrini, M., . . . Skidmore, M. A. (2019). A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease. MARINE DRUGS, 17(5). doi:10.3390/md17050293

DOI: 10.3390/md17050293

Inhibition of BACE1, the beta-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus (Journal article)

Mycroft-West, C. J., Devlin, A. J., Cooper, L. C., Procter, P., Miller, G. J., Fernig, D. G., . . . Skidmore, M. A. (2019). Inhibition of BACE1, the beta-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus. NEURAL REGENERATION RESEARCH, 15(8), 1546-1553. doi:10.4103/1673-5374.274341

DOI: 10.4103/1673-5374.274341

A glycosaminoglycan extract from Portunus pelagicus inhibits BACE1, the β secretase implicated in Alzheimer’s disease (Preprint)

DOI: 10.1101/613695

Introduction to the Molecules Special Edition Entitled 'Heparan Sulfate and Heparin: Challenges and Controversies': Some Outstanding Questions in Heparan Sulfate and Heparin Research (Journal article)

Yates, E. A., Gallagher, J. T., & Guerrini, M. (2019). Introduction to the Molecules Special Edition Entitled 'Heparan Sulfate and Heparin: Challenges and Controversies': Some Outstanding Questions in Heparan Sulfate and Heparin Research. MOLECULES, 24(7). doi:10.3390/molecules24071399

DOI: 10.3390/molecules24071399

By-Products of Heparin Production Provide a Diverse Source of Heparin-like and Heparan Sulfate Glycosaminoglycans. (Journal article)

Taylor, S. L., Hogwood, J., Guo, W., Yates, E. A., & Turnbull, J. E. (2019). By-Products of Heparin Production Provide a Diverse Source of Heparin-like and Heparan Sulfate Glycosaminoglycans.. Scientific reports, 9(1), 2679. doi:10.1038/s41598-019-39093-6

DOI: 10.1038/s41598-019-39093-6

Low sulfated heparins target multiple proteins for central nervous system repair (Journal article)

McCanney, G. A., McGrath, M. A., Otto, T. D., Burchmore, R., Yates, E. A., Bavington, C. D., . . . Barnett, S. C. (2019). Low sulfated heparins target multiple proteins for central nervous system repair. GLIA, 67(4), 668-687. doi:10.1002/glia.23562

DOI: 10.1002/glia.23562

Analysis of solid-state heparin samples by ATR-FTIR spectroscopy (Preprint)

DOI: 10.1101/538074

NMR in the Characterization of Complex Mixture Drugs (Chapter)

Guerrini, M., Rudd, T. R., & Yates, E. A. (2019). NMR in the Characterization of Complex Mixture Drugs. In R. Sasisekharan, S. L. Lee, A. Rosenberg, & L. A. Walker (Eds.), The Science and Regulations of Naturally Derived Complex Drugs (Vol. 32, pp. 115-137). Springer International Publishing. doi:10.1007/978-3-030-11751-1_7

DOI: 10.1007/978-3-030-11751-1_7

2018

Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease (Journal article)

Mycroft-West, C. J., Yates, E. A., & Skidmore, M. A. (2018). Marine glycosaminoglycan-like carbohydrates as potential drug candidates for infectious disease. BIOCHEMICAL SOCIETY TRANSACTIONS, 46, 919-929. doi:10.1042/BST20170404

DOI: 10.1042/BST20170404

New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors (Journal article)

Byrne, D. P., Li, Y., Ramakrishnan, K., Barsukov, I. L., Yates, E. A., Eyers, C. E., . . . Eyers, P. A. (2018). New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors. BIOCHEMICAL JOURNAL, 475(15), 2417-2433. doi:10.1042/BCJ20180265

DOI: 10.1042/BCJ20180265

Potential role for Streptococcus gordonii-derived hydrogen peroxide in heme acquisition by Porphyromonas gingivalis (Journal article)

Brown, J. L., Yates, E. A., Bielecki, M., Olczak, T., & Smalley, J. W. (2018). Potential role for Streptococcus gordonii-derived hydrogen peroxide in heme acquisition by Porphyromonas gingivalis. MOLECULAR ORAL MICROBIOLOGY, 33(4), 322-335. doi:10.1111/omi.12229

DOI: 10.1111/omi.12229

Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection (Journal article)

Vicenzi, E., Pagani, I., Ghezzi, S., Taylor, S. L., Rudd, T. R., Lima, M. A., . . . Yates, E. A. (2018). Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection. BIOCHEMICAL SOCIETY TRANSACTIONS, 46, 609-617. doi:10.1042/BST20170399

DOI: 10.1042/BST20170399

An Inexpensive, Pulsed, and Multiple Wavelength Bench-Top Light Source for Biological Spectroscopy (Journal article)

Holman, J., Skidmore, M., & Yates, E. (n.d.). An Inexpensive, Pulsed, and Multiple Wavelength Bench-Top Light Source for Biological Spectroscopy. Plasma, 1(1), 78-89. doi:10.3390/plasma1010008

DOI: 10.3390/plasma1010008

New tools for carbohydrate sulphation analysis: Heparan Sulphate 2-O-sulphotranserase (HS2ST) is a target for small molecule protein kinase inhibitors (Preprint)

DOI: 10.1101/296533

Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans (Journal article)

Rogerson, E., Pelletier, J., Acosta-Serrano, A., Rose, C., Taylor, S., Guimond, S., . . . Yates, E. (2018). Variations in the Peritrophic Matrix Composition of Heparan Sulphate from the Tsetse Fly, Glossina morsitans morsitans. PATHOGENS, 7(1). doi:10.3390/pathogens7010032

DOI: 10.3390/pathogens7010032

In vitro investigations on the effects of semi-synthetic, sulphated carbohydrates on the immune status of cultured common carp (Cyprinus carpio) leucocytes (Journal article)

Kareem, N., Yates, E., Skidmore, M., & Hoole, D. (2018). In vitro investigations on the effects of semi-synthetic, sulphated carbohydrates on the immune status of cultured common carp (Cyprinus carpio) leucocytes. FISH & SHELLFISH IMMUNOLOGY, 74, 213-222. doi:10.1016/j.fsi.2017.12.047

DOI: 10.1016/j.fsi.2017.12.047

2017

Coupling of vinculin to F-actin demands Syndecan-4 proteoglycan (Journal article)

Cavalheiro, R. P., Lima, M. A., Jarrouge-Boucas, T. R., Viana, G. M., Lopes, C. C., Coulson-Thomas, V. J., . . . Nader, H. B. (2017). Coupling of vinculin to F-actin demands Syndecan-4 proteoglycan. MATRIX BIOLOGY, 63, 23-37. doi:10.1016/j.matbio.2016.12.006

DOI: 10.1016/j.matbio.2016.12.006

Identification of Heparin Modifications and Polysaccharide Inhibitors of Plasmodium falciparum Merozoite Invasion That Have Potential for Novel Drug Development (Journal article)

Boyle, M. J., Skidmore, M., Dickerman, B., Cooper, L., Devlin, A., Yates, E., . . . Beeson, J. G. (2017). Identification of Heparin Modifications and Polysaccharide Inhibitors of Plasmodium falciparum Merozoite Invasion That Have Potential for Novel Drug Development. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 61(11). doi:10.1128/AAC.00709-17

DOI: 10.1128/AAC.00709-17

Terahertz: dictating the frequency of life. Do macromolecular vibrational modes impose thermal limitations on terrestrial life? (Journal article)

Hand, K., & Yates, E. (2017). Terahertz: dictating the frequency of life. Do macromolecular vibrational modes impose thermal limitations on terrestrial life?. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 14(136). doi:10.1098/rsif.2017.0673

DOI: 10.1098/rsif.2017.0673

A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence (Journal article)

Skidmore, M. A., Mustaffa, K. M. F., Cooper, L. C., Guimond, S. E., Yates, E. A., & Craig, A. G. (2017). A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence. PLOS ONE, 12(10). doi:10.1371/journal.pone.0186276

DOI: 10.1371/journal.pone.0186276

Insights into the role of 3-O-sulfotransferase in heparan sulfate biosynthesis (Journal article)

Zorel Meneghetti, M. C., Ferreira, T. G., Tashima, A. K., Chavante, S. F., Yates, E. A., Liu, J., . . . Lima, M. A. (2017). Insights into the role of 3-O-sulfotransferase in heparan sulfate biosynthesis. ORGANIC & BIOMOLECULAR CHEMISTRY, 15(32), 6792-6799. doi:10.1039/c7ob01533j

DOI: 10.1039/c7ob01533j

Molecular Origins of the Compatibility between Glycosaminoglycans and A beta 40 Amyloid Fibrils (Journal article)

Stewart, K. L., Hughes, E., Yates, E. A., Middleton, D. A., & Radford, S. E. (2017). Molecular Origins of the Compatibility between Glycosaminoglycans and A beta 40 Amyloid Fibrils. JOURNAL OF MOLECULAR BIOLOGY, 429(16), 2449-2462. doi:10.1016/j.jmb.2017.07.003

DOI: 10.1016/j.jmb.2017.07.003

19F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy (Journal article)

Lima, M. A., Cavalheiro, R. P., M Viana, G., Meneghetti, M. C. Z., Rudd, T. R., Skidmore, M. A., . . . Yates, E. A. (2017). 19F labelled glycosaminoglycan probes for solution NMR and non-linear (CARS) microscopy. Glycoconjugate Journal, 34, 405-410. doi:10.1007/s10719-016-9723-x

DOI: 10.1007/s10719-016-9723-x

New Methods for the Analysis of Heterogeneous Polysaccharides - Lessons Learned from the Heparin Crisis (Chapter)

Rudd, T. R., Yates, E. A., & Guerrini, M. (2017). New Methods for the Analysis of Heterogeneous Polysaccharides - Lessons Learned from the Heparin Crisis. In NMR IN GLYCOSCIENCE AND GLYCOTECHNOLOGY (Vol. 10, pp. 305-334). Retrieved from https://www.webofscience.com/

CHAPTER 14 New Methods for the Analysis of Heterogeneous Polysaccharides – Lessons Learned from the Heparin Crisis (Chapter)

Rudd, T. R., Yates, E. A., & Guerrini, M. (2017). CHAPTER 14 New Methods for the Analysis of Heterogeneous Polysaccharides – Lessons Learned from the Heparin Crisis. In NMR in Glycoscience and Glycotechnology (pp. 305-334). Royal Society of Chemistry (RSC). doi:10.1039/9781782623946-00305

DOI: 10.1039/9781782623946-00305

New Applications of Heparin and Other Glycosaminoglycans (Journal article)

Lima, M., Rudd, T., & Yates, E. (2017). New Applications of Heparin and Other Glycosaminoglycans. MOLECULES, 22(5). doi:10.3390/molecules22050749

DOI: 10.3390/molecules22050749

The nature of the conserved basic amino acid sequences found among 437 heparin binding proteins determined by network analysis. (Journal article)

Rudd, T. R., Preston, M. D., & Yates, E. A. (2017). The nature of the conserved basic amino acid sequences found among 437 heparin binding proteins determined by network analysis.. Molecular bioSystems, 13(5), 852-865. doi:10.1039/c6mb00857g

DOI: 10.1039/c6mb00857g

Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells (Journal article)

Ghezzi, S., Cooper, L., Rubio, A., Pagani, I., Capobianchi, M. R., Ippolito, G., . . . Vicenzi, E. (2017). Heparin prevents Zika virus induced-cytopathic effects in human neural progenitor cells. Antiviral Research, 140, 13-17. doi:10.1016/j.antiviral.2016.12.023

DOI: 10.1016/j.antiviral.2016.12.023

Investigating the relationship between temperature, conformation and calcium binding in heparin model oligosaccharides (Journal article)

Hughes, A., Meneghetti, M., Huang, T. -Y., Hung, S. -C., Elli, S., Guerrini, M., . . . Yates, E. (2017). Investigating the relationship between temperature, conformation and calcium binding in heparin model oligosaccharides. CARBOHYDRATE RESEARCH, 438, 58-64. doi:10.1016/j.carres.2016.12.002

DOI: 10.1016/j.carres.2016.12.002

2016

Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors (Journal article)

Macchi, E., Rudd, T. R., Raman, R., Sasisekharan, R., Yates, E. A., Naggi, A., . . . Elli, S. (2016). Nuclear Magnetic Resonance and Molecular Dynamics Simulation of the Interaction between Recognition Protein H7 of the Novel Influenza Virus H7N9 and Glycan Cell Surface Receptors. BIOCHEMISTRY, 55(48), 6605-6616. doi:10.1021/acs.biochem.6b00693

DOI: 10.1021/acs.biochem.6b00693

Heparan sulfate and heparin interactions with proteins (Journal article)

Yates, E. A., Meneghetti, M. C. Z., Hughes, A. J., Rudd, T. R., Nader, H. B., Powell, A. K., & Lima, M. A. (2016). Heparan sulfate and heparin interactions with proteins. Journal of the Royal Society Interface. doi:10.1098/rsif.2015.0589

DOI: 10.1098/rsif.2015.0589

Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity (Journal article)

Ahmed, Y. A., Yates, E. A., Moss, D. J., Loeven, M. A., Hussain, S. -A., Hohenester, E., . . . Powell, A. K. (2016). Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity. Molecular Biosystems, 12(10), 3166-3175. doi:10.1039/c6mb00432f

DOI: 10.1039/c6mb00432f

Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-beta Fibrils (Journal article)

Stewart, K. L., Hughes, E., Yates, E. A., Akien, G. R., Huang, T. -Y., Lima, M. A., . . . Middleton, D. A. (2016). Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-beta Fibrils. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138(27), 8328-8331. doi:10.1021/jacs.6b02816

DOI: 10.1021/jacs.6b02816

Recent innovations in the structural analysis of heparin. (Journal article)

Yates, E. A., & Rudd, T. R. (2016). Recent innovations in the structural analysis of heparin.. International journal of cardiology, 212 Suppl 1, S5-S9. doi:10.1016/s0167-5273(16)12002-9

DOI: 10.1016/s0167-5273(16)12002-9

JOHANN PETER GRIESS FRS (1829-88): VICTORIAN BREWER AND SYNTHETIC DYE CHEMIST (Journal article)

Yates, E., & Yates, A. (2016). JOHANN PETER GRIESS FRS (1829-88): VICTORIAN BREWER AND SYNTHETIC DYE CHEMIST. NOTES AND RECORDS-THE ROYAL SOCIETY JOURNAL OF THE HISTORY OF SCIENCE, 70(1), 65-81. doi:10.1098/rsnr.2015.0020

DOI: 10.1098/rsnr.2015.0020

Heparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification (Journal article)

Li, Y., Sun, C., Yates, E. A., Jiang, C., Wilkinson, M. C., & Fernig, D. G. (2016). Heparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification. Open Biology, 6(3). doi:10.1098/rsob.150275

DOI: 10.1098/rsob.150275

Recent innovations in the structural analysis of heparin (Journal article)

Yates, E. A., & Rudd, T. R. (2016). Recent innovations in the structural analysis of heparin. INTERNATIONAL JOURNAL OF CARDIOLOGY, 212, S5-S9. Retrieved from https://www.webofscience.com/

2015

SimpleDSFviewer: a tool to analyse and view differential scanning fluorimetry data for characterising protein thermal stability and interactions (Preprint)

DOI: 10.7287/peerj.preprints.1555

SimpleDSFviewer: a tool to analyse and view differential scanning fluorimetry data for characterising protein thermal stability and interactions (Preprint)

DOI: 10.7287/peerj.preprints.1555v1

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis (Journal article)

Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L. -Y., . . . Yu, L. -G. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. ONCOTARGET, 6(27), 23671-23687. doi:10.18632/oncotarget.4409

DOI: 10.18632/oncotarget.4409

Heparan sulfate and heparin interactions with proteins (Journal article)

Meneghetti, M. C. Z., Hughes, A. J., Rudd, T. R., Nader, H. B., Powell, A. K., Yates, E. A., & Lima, M. A. (2015). Heparan sulfate and heparin interactions with proteins. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 12(110). doi:10.1098/rsif.2015.0589

DOI: 10.1098/rsif.2015.0589

Differentiation of Generic Enoxaparins Marketed in the United States by Employing NMR and Multivariate Analysis (Journal article)

Guerrini, M., Rudd, T. R., Mauri, L., Macchi, E., Fareed, J., Yates, E. A., . . . Torri, G. (2015). Differentiation of Generic Enoxaparins Marketed in the United States by Employing NMR and Multivariate Analysis. ANALYTICAL CHEMISTRY, 87(16), 8275-8283. doi:10.1021/acs.analchem.5b01366

DOI: 10.1021/acs.analchem.5b01366

Heparan sulfate and heparin: Structure and function (Chapter)

Lima, M. A., Cavalheiro, R. P., Meneghetti, M. C. Z., Nobre, L. T. D. B., Viana, G. M., Yates, E. A., & Nader, H. B. (2015). Heparan sulfate and heparin: Structure and function. In Sulfated Polysaccharides (pp. 1-16).

Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding (Journal article)

Solari, V., Rudd, T. R., Guimond, S. E., Powell, A. K., Turnbull, J. E., & Yates, E. A. (2015). Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding. ORGANIC & BIOMOLECULAR CHEMISTRY, 13(21), 6066-6072. doi:10.1039/c5ob00564g

DOI: 10.1039/c5ob00564g

Inhibition of influenza H5N1 invasion by modified heparin derivatives (Journal article)

Skidmore, M. A., Kajaste-Rudnitski, A., Wells, N. M., Guimond, S. E., Rudd, T. R., Yates, E. A., & Vicenzi, E. (2015). Inhibition of influenza H5N1 invasion by modified heparin derivatives. MEDCHEMCOMM, 6(4), 640-646. doi:10.1039/c4md00516c

DOI: 10.1039/c4md00516c

Detection of interaction between protein trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism (Journal article)

Hughes, A. J., Rudd, T. R., Wright, G. S. A., Fernig, D. G., Siligardi, G., & Yates, E. A. (2015). Detection of interaction between protein trytophan residues and small or macromolecular ligands by synchrotron radiation magnetic circular dichroism. ANALYTICAL METHODS, 7(5), 1667-1671. doi:10.1039/c4ay02618g

DOI: 10.1039/c4ay02618g

Heparin derivatives for the targeting of multiple activities in the inflammatory response (Journal article)

Veraldi, N., Hughes, A. J., Rudd, T. R., Thomas, H. B., Edwards, S. W., Hadfield, L., . . . Yates, E. A. (2015). Heparin derivatives for the targeting of multiple activities in the inflammatory response. CARBOHYDRATE POLYMERS, 117, 400-407. doi:10.1016/j.carbpol.2014.09.079

DOI: 10.1016/j.carbpol.2014.09.079

Enhanced Tumorigenic Potential of Colorectal Cancer Cells by Extracellular Sulfatases (Journal article)

Vicente, C. M., Lima, M. A., Yates, E. A., Nader, H. B., & Toma, L. (2015). Enhanced Tumorigenic Potential of Colorectal Cancer Cells by Extracellular Sulfatases. MOLECULAR CANCER RESEARCH, 13(3), 510-523. doi:10.1158/1541-7786.MCR-14-0372

DOI: 10.1158/1541-7786.MCR-14-0372

Heparin derivatives for the targeting of multiple activities in the inflammatory response (Journal article)

Veraldi, N., Hughes, A. J., Rudd, T. R., Thomas, H. B., Edwards, S. W., Hadfield, L., . . . Yates, E. A. (2015). Heparin derivatives for the targeting of multiple activities in the inflammatory response. Carbohydrate Polymers, 117, 400-407. doi:10.1016/j.carbpol.2014.09.079

DOI: 10.1016/j.carbpol.2014.09.079

2014

MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival. (Journal article)

Solari, V., Borriello, L., Turcatel, G., Shimada, H., Sposto, R., Esteban Fernandz, G., . . . DeClerck, Y. A. (2014). MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival.. Cancer Research, 74(21), 5999-6009. doi:10.1158/0008-5472.CAN-13-2513

DOI: 10.1158/0008-5472.CAN-13-2513

MYCN-dependent expression of sulfatase2 regulates neuroblastoma cell survival (Journal article)

Solari, V., Borriello, L., Fernandez, G. E., Shimada, H., Sposto, R., Asgharzadeh, S., . . . Declerck, Y. A. (2014). MYCN-dependent expression of sulfatase2 regulates neuroblastoma cell survival. CANCER RESEARCH, 74(19). doi:10.1158/1538-7445.AM2014-3963

DOI: 10.1158/1538-7445.AM2014-3963

Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry (Journal article)

Nieves, D., Azmi, N., Xu, R., Levy, R., Yates, E., & Fernig, D. (2014). Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry. Chemical Communications, 50(86), 13157-13160. doi:10.1039/c4cc05909c

DOI: 10.1039/c4cc05909c

Insights into the human glycan receptor conformation of 1918 pandemic hemagglutinin-glycan complexes derived from nuclear magnetic resonance and molecular dynamics studies. (Journal article)

Elli, S., Macchi, E., Rudd, T. R., Rahman, R., Sassaki, G., Viswanathan, K., . . . Guerrini, M. (2014). Insights into the human glycan receptor conformation of 1918 pandemic hemagglutinin-glycan complexes derived from nuclear magnetic resonance and molecular dynamics studies.. Biochemistry, 53(25), 4122-4135. doi:10.1021/bi500338r

DOI: 10.1021/bi500338r

A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated D-glucosamine groups in an unusual trisaccharide sequence (Journal article)

Chavante, S. F., Brito, A. S., Lima, M., Yates, E., Nader, H., Guerrini, M., . . . Bisio, A. (2014). A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated D-glucosamine groups in an unusual trisaccharide sequence. CARBOHYDRATE RESEARCH, 390, 59-66. doi:10.1016/j.carres.2014.03.002

DOI: 10.1016/j.carres.2014.03.002

A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated d-glucosamine groups in an unusual trisaccharide sequence (Journal article)

Chavante, S. F., Brito, A. S., Lima, M., Yates, E., Nader, H., Guerrini, M., . . . Bisio, A. (2014). A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated d-glucosamine groups in an unusual trisaccharide sequence. Carbohydrate Research, 390, 59-66. doi:10.1016/j.carres:2014.03.002

DOI: 10.1016/j.carres:2014.03.002

A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential (Journal article)

Brito, A. S., Cavalcante, R. S., Palhares, L. C. G. F., Hughes, A. J., Andrade, G. P. V., Yates, E. A., . . . Chavante, S. F. (2014). A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential. Carbohydrate Polymers.

A non-hemorrhagic hybrid heparin/heparan sulfate with anticoagulant potential (Journal article)

DOI: 10.1016/j.carbpol.2013.08.063

Characterisation of the interaction of neuropilin-1 with heparin and a heparan sulfate mimetic library of heparin-derived sugars (Journal article)

Uniewicz, K. A., Ori, A., Ahmed, Y. A., Yates, E. A., & Fernig, D. G. (2014). Characterisation of the interaction of neuropilin-1 with heparin and a heparan sulfate mimetic library of heparin-derived sugars. PEERJ, 2. doi:10.7717/peerj.461

DOI: 10.7717/peerj.461

Dicroismo Circular (Chapter)

Lima, M. A., Yates, E. A., Tersariol, I. L. S., & Nader, H. B. (2014). Dicroismo Circular. In H. Verli (Ed.), Bioinformatica a Flexibilidade Molecular (pp. 219-228). Porto Alegre: Universidade Federal do Rio Grande do Sul.

Heparin Derivatives for the Targeting of Multiple Activities in the Inflammatory Response (Journal article)

Veraldi, N., Hughes, A. J., Rudd, T. R., Thomas, H. B., Edwards, S. W., Hadfield, L., . . . Yates, E. A. (2014). Heparin Derivatives for the Targeting of Multiple Activities in the Inflammatory Response. Carbohydrate Polymers.

MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival (Journal article)

Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry: A route to covalent nanoparticle-biomolecule conjugates. (Journal article)

Nieves, D. J., Azmi, N. S., Xu, R., LÃ©vy, R., Yates, E. A., & Fernig, D. G. (2014). Monovalent maleimide functionalization of gold nanoparticles via copper-free click chemistry: A route to covalent nanoparticle-biomolecule conjugates.. Chemical Communications (Cambridge).

On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca2+ (Journal article)

Cordula, C. R., Lima, M. A., Shinjo, S. K., Gesteira, T. F., Pol-Fachin, L., Coulson-Thomas, V. J., . . . Tersariol, I. L. S. (2014). On the catalytic mechanism of polysaccharide lyases: evidence of His and Tyr involvement in heparin lysis by heparinase I and the role of Ca2+. MOLECULAR BIOSYSTEMS, 10(1), 54-64. doi:10.1039/c3mb70370c

DOI: 10.1039/c3mb70370c

2013

Human (α2→6) and Avian (α2→3) Sialylated Receptors of Influenza A Virus Show Distinct Conformations and Dynamics in Solution (Journal article)

Sassaki, G. L., Elli, S., Rudd, T. R., Macchi, E., Yates, E. A., Naggi, A., . . . Guerrini, M. (2013). Human (α2→6) and Avian (α2→3) Sialylated Receptors of Influenza A Virus Show Distinct Conformations and Dynamics in Solution. BIOCHEMISTRY, 52(41), 7217-7230. doi:10.1021/bi400677n

DOI: 10.1021/bi400677n

Unravelling Structural Information from Complex Mixtures Utilizing Correlation Spectroscopy Applied to HSQC Spectra (Journal article)

Rudd, T. R., Macchi, E., Muzi, L., Ferro, M., Gaudesi, D., Torri, G., . . . Yates, E. A. (2013). Unravelling Structural Information from Complex Mixtures Utilizing Correlation Spectroscopy Applied to HSQC Spectra. ANALYTICAL CHEMISTRY, 85(15), 7487-7493. doi:10.1021/ac4014379

DOI: 10.1021/ac4014379

Analysis of the fibroblast growth factor receptor (FGFR) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network (Journal article)

Xu, R., Rudd, T. R., Hughes, A. J., Siligardi, G., Fernig, D. G., & Yates, E. A. (2013). Analysis of the fibroblast growth factor receptor (FGFR) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network. FEBS JOURNAL, 280(10), 2260-2270. doi:10.1111/febs.12201

DOI: 10.1111/febs.12201

Antithrombin stabilisation by sulfated carbohydrates correlates with anticoagulant activity (Journal article)

Lima, M. A., Hughes, A. J., Veraldi, N., Rudd, T. R., Hussain, R., Brito, A. S., . . . Yates, E. A. (2013). Antithrombin stabilisation by sulfated carbohydrates correlates with anticoagulant activity. MEDCHEMCOMM, 4(5), 870-873. doi:10.1039/c3md00048f

DOI: 10.1039/c3md00048f

Human (α2→6) and avian (α2→3) sialylated receptors of influenza A virus show distinct conformations and dynamics in solution (Journal article)

Sassaki, G., Elli, S., Rudd, T., Macchi, E., Yates, E., Naggi, A., . . . Guerrini, M. (2013). Human (α2→6) and avian (α2→3) sialylated receptors of influenza A virus show distinct conformations and dynamics in solution. Biochemistry, 52, 7217-7230. doi:10.1021/bi4000677n

DOI: 10.1021/bi4000677n

2012

Site-Specific Identification of an Aß Fibril-Heparin Interaction Site by Using Solid-State NMR Spectroscopy (Journal article)

Madine, J., Pandya, M. J., Hicks, M. R., Rodger, A., Yates, E. A., Radford, S. E., & Middleton, D. A. (2012). Site-Specific Identification of an Aß Fibril-Heparin Interaction Site by Using Solid-State NMR Spectroscopy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(52), 13140-13143. doi:10.1002/anie.201204459

DOI: 10.1002/anie.201204459

Site‐Specific Identification of an Aβ Fibril–Heparin Interaction Site by Using Solid‐State NMR Spectroscopy (Journal article)

Madine, J., Pandya, M. J., Hicks, M. R., Rodger, A., Yates, E. A., Radford, S. E., & Middleton, D. A. (2012). Site‐Specific Identification of an Aβ Fibril–Heparin Interaction Site by Using Solid‐State NMR Spectroscopy. Angewandte Chemie, 124(52), 13317-13320. doi:10.1002/ange.201204459

DOI: 10.1002/ange.201204459

Diversification of the Structural Determinants of Fibroblast Growth Factor-Heparin Interactions IMPLICATIONS FOR BINDING SPECIFICITY (Journal article)

Xu, R., Ori, A., Rudd, T. R., Uniewicz, K. A., Ahmed, Y. A., Guimond, S. E., . . . Fernig, D. G. (2012). Diversification of the Structural Determinants of Fibroblast Growth Factor-Heparin Interactions IMPLICATIONS FOR BINDING SPECIFICITY. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(47). doi:10.1074/jbc.M112.398826

DOI: 10.1074/jbc.M112.398826

A zinc complex of heparan sulfate destabilises lysozyme and alters its conformation (Journal article)

Hughes, A. J., Hussain, R., Cosentino, C., Guerrini, M., Siligardi, G., Yates, E. A., & Rudd, T. R. (2012). A zinc complex of heparan sulfate destabilises lysozyme and alters its conformation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 425(4), 794-799. doi:10.1016/j.bbrc.2012.07.154

DOI: 10.1016/j.bbrc.2012.07.154

How To Find a Needle (or Anything Else) in a Haystack: Two-Dimensional Correlation Spectroscopy-Filtering with Iterative Random Sampling Applied to Pharmaceutical Heparin (Journal article)

Rudd, T. R., Macchi, E., Gardini, C., Muzi, L., Guerrini, M., Yates, E. A., & Torri, G. (2012). How To Find a Needle (or Anything Else) in a Haystack: Two-Dimensional Correlation Spectroscopy-Filtering with Iterative Random Sampling Applied to Pharmaceutical Heparin. ANALYTICAL CHEMISTRY, 84(15), 6841-6847. doi:10.1021/ac301428d

DOI: 10.1021/ac301428d

Fundamental differences in model cell-surface polysaccharides revealed by complementary optical and spectroscopic techniques (Journal article)

Holder, G. M., Bowfield, A., Surman, M., Suepfle, M., Moss, D., Tucker, C., . . . Weightman, P. (2012). Fundamental differences in model cell-surface polysaccharides revealed by complementary optical and spectroscopic techniques. SOFT MATTER, 8(24), 6521-6527. doi:10.1039/c2sm25239b

DOI: 10.1039/c2sm25239b

A highly efficient tree structure for the biosynthesis of heparan sulfate accounts for the commonly observed disaccharides and suggests a mechanism for domain synthesis (Journal article)

Rudd, T. R., & Yates, E. A. (2012). A highly efficient tree structure for the biosynthesis of heparan sulfate accounts for the commonly observed disaccharides and suggests a mechanism for domain synthesis. MOLECULAR BIOSYSTEMS, 8(5), 1499-1506. doi:10.1039/c2mb25019e

DOI: 10.1039/c2mb25019e

Following Protein-Glycosaminoglycan Polysaccharide Interactions with Differential Scanning Fluorimetry (Journal article)

Uniewicz, K. A., Ori, A., Rudd, T. R., Guerrini, M., Wilkinson, M. C., Fernig, D. G., & Yates, E. A. (2012). Following Protein-Glycosaminoglycan Polysaccharide Interactions with Differential Scanning Fluorimetry. PROTEOGLYCANS: METHODS AND PROTOCOLS, 836, 171-182. doi:10.1007/978-1-61779-498-8_12

DOI: 10.1007/978-1-61779-498-8_12

Clostridium difficile: a problem of concern in developed countries and still a mystery in Latin America (Journal article)

Balassiano, I. T., Yates, E. A., Domingues, R. M. C. P., & Ferreira, E. O. (2012). Clostridium difficile: a problem of concern in developed countries and still a mystery in Latin America. JOURNAL OF MEDICAL MICROBIOLOGY, 61(2), 169-179. doi:10.1099/jmm.0.037077-0

DOI: 10.1099/jmm.0.037077-0

Following Protein-Glycosaminoglycan Polysaccharide Interactions with Differential Scanning Fluorimetry (Chapter)

Uniewicz, K. A., Ori, A., Rudd, T. R., Guerrini, M., Wilkinson, M. C., Fernig, D. G., & Yates, E. A. (2012). Following Protein-Glycosaminoglycan Polysaccharide Interactions with Differential Scanning Fluorimetry. In F. Redini, & J. M. Walker (Eds.), Proteoglycans: methods and Protocols (pp. 171-182). New York: Humana Press, Springer.

Heparan sulphate, its derivatives and analogues share structural characteristics that can be exploited, particularly in inhibiting microbial attachment (Journal article)

Rudd, T. R., Hughes, A., Holman, J., de Oliveira Ferreira, E., Cavalcante Pilotto Domingues, R. M., & Yates, E. A. (2012). Heparan sulphate, its derivatives and analogues share structural characteristics that can be exploited, particularly in inhibiting microbial attachment. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 45(5), 386-391. doi:10.1590/S0100-879X2012007500048

DOI: 10.1590/S0100-879X2012007500048

Ordering and motional characteristics of extracellular matrix polysaccharides revealed by complementary optical and spectroscopic techniques (Journal article)

Holder, G. M., Bowfield, A., Surman, M., Suepfle, M., Moss, D., Rudd, T. R., . . . Weightman, P. (2012). Ordering and motional characteristics of extracellular matrix polysaccharides revealed by complementary optical and spectroscopic techniques. Soft Matter, 8, 6521.

Pinpointing the Abeta fibril-glycosaminoglycan interaction site using linear dichroism and solid state NMR (Journal article)

Madine, J., Pandya, M. J., Hicks, M. R., Rodger, A., Yates, E. A., Radford, S. E., & Middleton, D. A. (2012). Pinpointing the Abeta fibril-glycosaminoglycan interaction site using linear dichroism and solid state NMR. Angewandte Chemie.

2011

Low molecular weight heparins: Structural differentiation by spectroscopic and multivariate approaches (Journal article)

Lima, M. A., de Farias, E. H. C., Rudd, T. R., Ebner, L. F., Gesteira, T. F., Mendes, A., . . . Nader, H. B. (2011). Low molecular weight heparins: Structural differentiation by spectroscopic and multivariate approaches. CARBOHYDRATE POLYMERS, 85(4), 903-909. doi:10.1016/j.carbpol.2011.04.021

DOI: 10.1016/j.carbpol.2011.04.021

A robust method to quantify low molecular weight contaminants in heparin: detection of tris(2-n-butoxyethyl) phosphate (Journal article)

Sassaki, G. L., Riter, D. S., Santana Filho, A. P., Guerrini, M., Lima, M. A., Cosentino, C., . . . Iacomini, M. (2011). A robust method to quantify low molecular weight contaminants in heparin: detection of tris(2-n-butoxyethyl) phosphate. ANALYST, 136(11), 2330-2338. doi:10.1039/c0an01010c

DOI: 10.1039/c0an01010c

Construction and use of a library of bona fide heparins employing 1H NMR and multivariate analysis (Journal article)

Rudd, T. R., Gaudesi, D., Skidmore, M. A., Ferro, M., Guerrini, M., Mulloy, B., . . . Yates, E. A. (2011). Construction and use of a library of bona fide heparins employing 1H NMR and multivariate analysis. ANALYST, 136(7), 1380-1389. doi:10.1039/c0an00834f

DOI: 10.1039/c0an00834f

High-sensitivity visualisation of contaminants in heparin samples by spectral filtering of 1H NMR spectra (Journal article)

Rudd, T. R., Gaudesi, D., Lima, M. A., Skidmore, M. A., Mulloy, B., Torri, G., . . . Yates, E. A. (2011). High-sensitivity visualisation of contaminants in heparin samples by spectral filtering of 1H NMR spectra. ANALYST, 136(7), 1390-1398. doi:10.1039/c0an00835d

DOI: 10.1039/c0an00835d

Anaerobe/aerobe environmental flux determines protein expression profiles of Bacteroides fragilis, a redox pathogen (Journal article)

Ferreira, E. D. O., Yates, E., Jourlin, M., Liu, J., Pilotto Domingues, R. M. C., & Goldner, M. (2011). Anaerobe/aerobe environmental flux determines protein expression profiles of Bacteroides fragilis, a redox pathogen. ANAEROBE, 17(1), 4-14. doi:10.1016/j.anaerobe.2010.09.004

DOI: 10.1016/j.anaerobe.2010.09.004

A New Approach for Heparin Standardization: Combination of Scanning UV Spectroscopy, Nuclear Magnetic Resonance and Principal Component Analysis (Journal article)

Lima, M. A., Rudd, T. R., de Farias, E. H. C., Ebner, L. F., Gesteira, T. F., de Souza, L. M., . . . Nader, H. B. (2011). A New Approach for Heparin Standardization: Combination of Scanning UV Spectroscopy, Nuclear Magnetic Resonance and Principal Component Analysis. PLOS ONE, 6(1). doi:10.1371/journal.pone.0015970

DOI: 10.1371/journal.pone.0015970

Construction and use of a library of bona fide heparins employing 1H NMR and multivariate analysis. (Journal article)

Rudd, T. R., Gaudesi, D., Skidmore, M. A., Ferro, M., Guerrini, M., Mulloy, B., . . . Yates, E. A. (2011). Construction and use of a library of bona fide heparins employing 1H NMR and multivariate analysis.. Analyst. doi:10.0139/c0an00834f

DOI: 10.0139/c0an00834f

2010

Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships (Journal article)

Rudd, T. R., Uniewicz, K. A., Ori, A., Guimond, S. E., Skidmore, M. A., Gaudesi, D., . . . Yates, E. A. (2010). Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships. ORGANIC & BIOMOLECULAR CHEMISTRY, 8(23), 5390-5397. doi:10.1039/c0ob00246a

DOI: 10.1039/c0ob00246a

Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection (Journal article)

Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, A. F., Yates, E. A., & Turnbull, J. E. (2010). Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection. Nature Protocols, 5(12), 1983-1992. doi:10.1038/nprot.2010.145

DOI: 10.1038/nprot.2010.145

Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection (Journal article)

Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, A. F., Yates, E. A., & Turnbull, J. E. (2010). Disaccharide compositional analysis of heparan sulfate and heparin polysaccharides using UV or high-sensitivity fluorescence (BODIPY) detection. NATURE PROTOCOLS, 5(12), 1983-1992. doi:10.1038/nprot.2010.145

DOI: 10.1038/nprot.2010.145

The conformation and structure of GAGs: recent progress and perspectives (Journal article)

Rudd, T. R., Skidmore, M. A., Guerrini, M., Hricovini, M., Powell, A. K., Siligardi, G., & Yates, E. A. (2010). The conformation and structure of GAGs: recent progress and perspectives. CURRENT OPINION IN STRUCTURAL BIOLOGY, 20(5), 567-574. doi:10.1016/j.sbi.2010.08.004

DOI: 10.1016/j.sbi.2010.08.004

The latent ampholytic nature of glycosaminoglycan (GAG) oligosaccharides facilitates their separation by isoelectric focusing (Journal article)

Holman, J., Skidmore, M. A., Rudd, T. R., & Yates, E. A. (2010). The latent ampholytic nature of glycosaminoglycan (GAG) oligosaccharides facilitates their separation by isoelectric focusing. ANALYTICAL METHODS, 2(10), 1550-1554. doi:10.1039/c0ay00340a

DOI: 10.1039/c0ay00340a

Determining the anti-coagulant-independent anti-cancer effects of heparin (Journal article)

Solari, V., Jesudason, E. C., Turnbull, J. E., & Yates, E. A. (2010). Determining the anti-coagulant-independent anti-cancer effects of heparin. BRITISH JOURNAL OF CANCER, 103(4), 593-594. doi:10.1038/sj.bjc.6605808

DOI: 10.1038/sj.bjc.6605808

Determining the anti-coagulant-independent anti-cancer effects of heparin (Journal article)

Solari, V., Jesudason, E. C., Turnbull, J. E., & Yates, E. A. (2010). Determining the anti-coagulant-independent anti-cancer effects of heparin. British Journal of Cancer, 103(4), 593-594. doi:10.1038/sj.bjc.6605808

DOI: 10.1038/sj.bjc.6605808

Raman and Raman optical activity of glycosaminoglycans (Journal article)

Rudd, T. R., Hussain, R., Siligardi, G., & Yates, E. A. (2010). Raman and Raman optical activity of glycosaminoglycans. CHEMICAL COMMUNICATIONS, 46(23), 4124-4126. doi:10.1039/c001535k

DOI: 10.1039/c001535k

Conformational degeneracy restricts the effective information content of heparan sulfate (Journal article)

Rudd, T. R., & Yates, E. A. (2010). Conformational degeneracy restricts the effective information content of heparan sulfate. MOLECULAR BIOSYSTEMS, 6(5), 902-908. doi:10.1039/b923519a

DOI: 10.1039/b923519a

Differential Scanning Fluorimetry Measurement of Protein Stability Changes upon Binding to Glycosaminoglycans: A Screening Test for Binding Specificity (Journal article)

Uniewicz, K. A., Ori, A., Xu, R., Ahmed, Y., Wilkinson, M. C., Fernig, D. G., & Yates, E. A. (2010). Differential Scanning Fluorimetry Measurement of Protein Stability Changes upon Binding to Glycosaminoglycans: A Screening Test for Binding Specificity. ANALYTICAL CHEMISTRY, 82(9), 3796-3802. doi:10.1021/ac100188x

DOI: 10.1021/ac100188x

Generating heparan sulfate saccharide libraries for glycomics applications (Journal article)

Powell, A. K., Ahmed, Y. A., Yates, E. A., & Turnbull, J. E. (2010). Generating heparan sulfate saccharide libraries for glycomics applications. Nature Protocols, 5(5), 821-833. doi:10.1038/nprot.2010.17

DOI: 10.1038/nprot.2010.17

Generating heparan sulfate saccharide libraries for glycomics applications (Journal article)

Powell, A. K., Ahmed, Y. A., Yates, E. A., & Turnbull, J. E. (2010). Generating heparan sulfate saccharide libraries for glycomics applications. NATURE PROTOCOLS, 5(5), 821-833. doi:10.1038/nprot.2010.17

DOI: 10.1038/nprot.2010.17

'Differential Scanning Fluorimetry measurement of protein stability changes upon binding to glycosaminoglycans: a rapid screening test for binding specificity' (Journal article)

Uniewicz, K. A., Ori, A., Xu, R., Ahmed, Y., Fernig, D. G., & Yates, E. A. (2010). 'Differential Scanning Fluorimetry measurement of protein stability changes upon binding to glycosaminoglycans: a rapid screening test for binding specificity'. Analytical Chemistry, 82, 3796-3802.

A key biological signalling system promises new routes to intervention in medically important processes (Report)

Rudd, T. R., Skidmore, M. A., Guimond, S. E., Xu, R., Hussain, R., Fernig, D. G., . . . Yates, E. A. (2010). A key biological signalling system promises new routes to intervention in medically important processes. Didcot, Oxfordshire: Diamond light Source Ltd.,.

Carbohydrate composition analysis of heparin and heparan sulphate derived polymers (Journal article)

Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, A. F., Yates, E. A., & Turnbull, J. E. (2010). Carbohydrate composition analysis of heparin and heparan sulphate derived polymers. Nature Protocols.

Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships (Journal article)

Rudd, T. R., Uniewicz, K. A., Ori, A., Guimond, S. E., Skidmore, M. A., Gaudesi, D., . . . Yates, E. A. (2010). Comparable stabilisation, structural changes and activities can be induced in FGF by a variety of HS and non-GAG analogues: implications for sequence-activity relationships. Organic & Biomolecular Chemistry, 8(23), 5390. doi:10.1039/c0ob00246a

DOI: 10.1039/c0ob00246a

Disaccharide compositional analysis of HS and heparin polysaccharides using UV and high sensitivity fluorescence analysis (Journal article)

Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, F., Yates, E. A., & Turnbull, J. E. (2010). Disaccharide compositional analysis of HS and heparin polysaccharides using UV and high sensitivity fluorescence analysis. Nature Protocols.

Generating heparan sulfate saccharide libraries for glycomics screening (Journal article)

Powell, A. K., Ahmed, Y. A., Yates, E. A., & Turnbull, J. E. (2010). Generating heparan sulfate saccharide libraries for glycomics screening. Nature protocols, 5, 829.

The conformation and structure of GAGs: recent progress and perspectives (Journal article)

Rudd, T. R., Skidmore, M. A., Guerrini, M., Hricovini, M., Powell, A. K., Guimoind, S. E., & Yates, E. A. (2010). The conformation and structure of GAGs: recent progress and perspectives. Current Opinion in Structural Biology.

2009

Labelling heparan sulphate saccharides with chromophore, fluorescence and mass tags for HPLC and MS separations. (Journal article)

Skidmore, M., Atrih, A., Yates, E., & Turnbull, J. E. (2009). Labelling heparan sulphate saccharides with chromophore, fluorescence and mass tags for HPLC and MS separations.. Methods in molecular biology (Clifton, N.J.), 534, 157-169. doi:10.1007/978-1-59745-022-5_12

DOI: 10.1007/978-1-59745-022-5_12

Spectroscopic and Theoretical Approaches for the Determination of Heparin Saccharide Structure and the Study of Protein-Glycosaminoglycan Complexes in Solution (Journal article)

Rudd, T. R., Yates, E. A., & Hricovini, M. (2009). Spectroscopic and Theoretical Approaches for the Determination of Heparin Saccharide Structure and the Study of Protein-Glycosaminoglycan Complexes in Solution. CURRENT MEDICINAL CHEMISTRY, 16(35), 4750-4766. doi:10.2174/092986709789878193

DOI: 10.2174/092986709789878193

The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids (Journal article)

Rudd, T. R., Skidmore, M. A., Guimond, S. E., Holman, J., Turnbull, J. E., Lauder, R. M., . . . Yates, E. A. (2009). The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. THROMBOSIS AND HAEMOSTASIS, 102(5), 874-878. doi:10.1160/TH08-12-0797

DOI: 10.1160/TH08-12-0797

The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids (Journal article)

Guimond, S., Holman, J., Turnbull, J., Lauder, R., Fernig, D., Rudd, T., . . . Yates, E. (2009). The potential for circular dichroism as an additional facile and sensitive method of monitoring low-molecular-weight heparins and heparinoids. Thrombosis and Haemostasis, 102(11), 874-878. doi:10.1160/th08-12-0797

DOI: 10.1160/th08-12-0797

Rapid Purification and High Sensitivity Analysis of Heparan Sulfate from Cells and Tissues TOWARD GLYCOMICS PROFILING (Journal article)

Guimond, S. E., Puvirajesinghe, T. M., Skidmore, M. A., Kalus, I., Dierks, T., Yates, E. A., & Turnbull, J. E. (2009). Rapid Purification and High Sensitivity Analysis of Heparan Sulfate from Cells and Tissues TOWARD GLYCOMICS PROFILING. JOURNAL OF BIOLOGICAL CHEMISTRY, 284(38), 25714-25722. doi:10.1074/jbc.M109.032755

DOI: 10.1074/jbc.M109.032755

Cations Modulate Polysaccharide Structure To Determine FGF-FGFR Signaling: A Comparison of Signaling and Inhibitory Polysaccharide Interactions with FGF-1 in Solution (Journal article)

Guimond, S. E., Rudd, T. R., Skidmore, M. A., Ori, A., Gaudesi, D., Cosentino, C., . . . Yates, E. A. (2009). Cations Modulate Polysaccharide Structure To Determine FGF-FGFR Signaling: A Comparison of Signaling and Inhibitory Polysaccharide Interactions with FGF-1 in Solution. BIOCHEMISTRY, 48(22), 4772-4779. doi:10.1021/bi802318z

DOI: 10.1021/bi802318z

Exploiting a 13C-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils (Journal article)

Madine, J., Clayton, J. C., Yates, E. A., & Middleton, D. A. (2009). Exploiting a 13C-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils. ORGANIC & BIOMOLECULAR CHEMISTRY, 7(11), 2414-2420. doi:10.1039/b820808e

DOI: 10.1039/b820808e

Glycosaminoglycan origin and structure revealed by multivariate analysis of NMR and CD spectra (Journal article)

Rudd, T. R., Skidmore, M. A., Guimond, S. E., Cosentino, C., Torri, G., Fernig, D. G., . . . Yates, E. A. (2009). Glycosaminoglycan origin and structure revealed by multivariate analysis of NMR and CD spectra. GLYCOBIOLOGY, 19(1), 52-67. doi:10.1093/glycob/cwn103

DOI: 10.1093/glycob/cwn103

Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling (Journal article)

Guimond, S. E., Puvirajesinghe, T. M., Skidmore, M. A., Kalus, I., Dierks, T., Yates, E. A., & Turnbull, J. E. (2009). Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling. Journal of Biological Chemistry.

2008

Software Tool for the Structural Determination of Glycosaminoglycans by Mass Spectrometry (Journal article)

Tissot, B., Ceroni, A., Powell, A. K., Morris, H. R., Yates, E. A., Turnbull, J. E., . . . Haslam, S. M. (2008). Software Tool for the Structural Determination of Glycosaminoglycans by Mass Spectrometry. ANALYTICAL CHEMISTRY, 80(23), 9204-9212. doi:10.1021/ac8013753

DOI: 10.1021/ac8013753

Site-specific interactions of copper(II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques (Journal article)

Rudd, T. R., Skidmore, M. A., Guimond, S. E., Guerrini, M., Cosentino, C., Edge, R., . . . Yates, E. A. (2008). Site-specific interactions of copper(II) ions with heparin revealed with complementary (SRCD, NMR, FTIR and EPR) spectroscopic techniques. CARBOHYDRATE RESEARCH, 343(12), 2184-2193. doi:10.1016/j.carres.2007.12.019

DOI: 10.1016/j.carres.2007.12.019

The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation (Journal article)

Skidmore, M. A., Guimond, S. E., Rudd, T. R., Fernig, D. G., Turnbull, J. E., & Yates, E. A. (2008). The activities of heparan sulfate and its analogue heparin are dictated by biosynthesis, sequence, and conformation. CONNECTIVE TISSUE RESEARCH, 49(3-4), 140-144. doi:10.1080/03008200802148595

DOI: 10.1080/03008200802148595

Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation (Journal article)

Patel, V. N., Likar, K. M., Zisman-Rozen, S., Cowherd, S. N., Lassiter, K. S., Sher, I., . . . Hoffman, M. P. (2008). Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(14), 9308-9317. doi:10.1074/jbc.M709995200

DOI: 10.1074/jbc.M709995200

Disruption of rosetting in Plasmodium falciparum malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities (Journal article)

Skidmore, M. A., Dumax-Vorzet, A. F., Guimond, S. E., Rudd, T. R., Edwards, E. A., Turnbull, J. E., . . . Yates, E. A. (2008). Disruption of rosetting in Plasmodium falciparum malaria with chemically modified heparin and low molecular weight derivatives possessing reduced anticoagulant and other serine protease inhibition activities. JOURNAL OF MEDICINAL CHEMISTRY, 51(5), 1453-1458. doi:10.1021/jm701337t

DOI: 10.1021/jm701337t

Engineered heparins:: Novel β-secretase inhibitors as potential Alzheimer's disease therapeutics (Journal article)

Patey, S. J., Edwards, E. A., Yates, E. A., & Turnbull, J. E. (2008). Engineered heparins:: Novel β-secretase inhibitors as potential Alzheimer's disease therapeutics. NEURODEGENERATIVE DISEASES, 5(3-4), 197-199. doi:10.1159/000113701

DOI: 10.1159/000113701

Selective detection of protein secondary structural changes in solution protein-polysaccharide complexes using vibrational circular dichroism (VCD) (Journal article)

Rudd, T. R., Nichols, R. J., & Yates, E. A. (2008). Selective detection of protein secondary structural changes in solution protein-polysaccharide complexes using vibrational circular dichroism (VCD). JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(7), 2138-+. doi:10.1021/ja077675n

DOI: 10.1021/ja077675n

The redox potential interferes with the expression of laminin binding molecules in Bacteroides fragilis (Journal article)

de Oliveira Ferreira, E., Yates, E. A., Goldner, M., Vommaro, R. C., Costa e Silva Filho, F., Petropolis, D. B., & Pilotto Domingues, R. M. C. (2008). The redox potential interferes with the expression of laminin binding molecules in Bacteroides fragilis. MEMORIAS DO INSTITUTO OSWALDO CRUZ, 103(7), 683-689. Retrieved from https://www.webofscience.com/

2007

Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives (Journal article)

Rudd, T. R., Guimond, S. E., Skidmore, M. A., Duchesne, L., Guerrini, M., Torri, G., . . . Yates, E. A. (2007). Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives. GLYCOBIOLOGY, 17(9), 983-993. doi:10.1093/glycob/cwm062

DOI: 10.1093/glycob/cwm062

Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives. (Journal article)

Rudd, T. R., Guimond, S. E., Skidmore, M. A., Duchesne, L., Guerrini, M., Torri, G., . . . Yates, E. A. (2007). Influence of substitution pattern and cation binding on conformation and activity in heparin derivatives.. Glycobiology, 17(9), 983-993. doi:10.1093/glycob/cwm062

DOI: 10.1093/glycob/cwm062

Site-specific interactions of copper (II) ions with heparin revealed with complementary (Journal article)

Rudd, T. R., Skidmore, M. A., Guimond, S. E., Guerrini, M., Cosentino, C., Edge, R., . . . Yates, E. A. (2007). Site-specific interactions of copper (II) ions with heparin revealed with complementary. Carbohydrate Research. Retrieved from doi:10.1016/j.carres.2007.12.0

2006

High sensitivity separation and detection of heparan sulfate disaccharides (Journal article)

Skidmore, M. A., Guimond, S. E., Dumax-Vorzet, A. F., Atrih, A., Yates, E. A., & Turnbull, J. E. (2006). High sensitivity separation and detection of heparan sulfate disaccharides. JOURNAL OF CHROMATOGRAPHY A, 1135(1), 52-56. doi:10.1016/j.chroma.2006.09.064

DOI: 10.1016/j.chroma.2006.09.064

Heparin derivatives as inhibitors of BACE-1, the Alzheimer's β-secretase, with reduced activity against factor Xa and other proteases (Journal article)

Patey, S. J., Edwards, E. A., Yates, E. A., & Turnbull, J. E. (2006). Heparin derivatives as inhibitors of BACE-1, the Alzheimer's β-secretase, with reduced activity against factor Xa and other proteases. JOURNAL OF MEDICINAL CHEMISTRY, 49(20), 6129-6132. doi:10.1021/jm051221o

DOI: 10.1021/jm051221o

Engineered bio-active polysaccharides from heparin (Journal article)

Guimond, S. E., Turnbull, J. E., & Yates, E. A. (2006). Engineered bio-active polysaccharides from heparin. MACROMOLECULAR BIOSCIENCE, 6(8), 681-686. doi:10.1002/mabi.200600042

DOI: 10.1002/mabi.200600042

P4–250: Assessment of heparan–mimetics as novel Alzheimer therapeutics (Journal article)

Talbot, C. J., Hazeel, C., Patey, S., Yates, E., & Turnbull, J. (2006). P4–250: Assessment of heparan–mimetics as novel Alzheimer therapeutics. Alzheimer's & Dementia, 2(3S_Part_19). doi:10.1016/j.jalz.2006.05.1989

DOI: 10.1016/j.jalz.2006.05.1989

P4–304: Novel beta–secretase inhibitors: Development of heparin analogues as Alzheimer's therapeutics (Journal article)

Patey, S. J., Yates, E. A., Edwards, E. A., Hazeel, C., Talbot, C., & Turnbull, J. E. (2006). P4–304: Novel beta–secretase inhibitors: Development of heparin analogues as Alzheimer's therapeutics. Alzheimer's & Dementia, 2(3S_Part_20). doi:10.1016/j.jalz.2006.05.2045

DOI: 10.1016/j.jalz.2006.05.2045

Protein-GAG interactions: new surface-based techniques, spectroscopies and nanotechnology probes (Conference Paper)

Yates, E. A., Terry, C. J., Rees, C., Rudd, T. R., Duchesne, L., Skidmore, M. A., . . . Fernig, D. G. (2006). Protein-GAG interactions: new surface-based techniques, spectroscopies and nanotechnology probes. In BIOCHEMICAL SOCIETY TRANSACTIONS Vol. 34 (pp. 427-430). doi:10.1042/BST0340427

DOI: 10.1042/BST0340427

Heparin derivatives as inhibitors of BACE-1, the Alzheimer's beta-secretase with reduced activity against factor Xa and other proteases (Journal article)

Patey, S. J., Edwards, E. A., Yates, E. A., & Turnbull, J. E. (2006). Heparin derivatives as inhibitors of BACE-1, the Alzheimer's beta-secretase with reduced activity against factor Xa and other proteases. Journal of medicinal chemistry, in pre.

Oligosaccharides as novel agents for treating Alzheimer's disease (Journal article)

Turnbull, J. E., Patey, S. J., & Yates, E. A. (2006). Oligosaccharides as novel agents for treating Alzheimer's disease. Unknown Journal, UK Pat.

Role of heparan sulphates in neuronal stem cell differentiation (Journal article)

Turnbull, J. E., Hemers, E., Limaye, P., Burrell, H., Drummond, K., Wells, N., . . . Murray, P. (2006). Role of heparan sulphates in neuronal stem cell differentiation. Endocrine Abstracts, 11, S38.

Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Consideartions for Surface Immobilisation of HS/Heparin Saccharides and Monitoring their Interactions with Binding Proteins (Chapter)

Rudd, T. R., Skidmore, M. A., & Yates, E. A. (2006). Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Consideartions for Surface Immobilisation of HS/Heparin Saccharides and Monitoring their Interactions with Binding Proteins. In H. Garg, R. Linhardt, & C. Hales (Eds.), Chemistry and biology of heparin and heparan sulfate (pp. Chapter 12). Oxford: Elsevier.

2005

Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Considerations for Surface Immobilisation of HS/Heparin Saccharides and Monitoring Their Interactions with Binding Proteins (Chapter)

Rudd, T., Skidmore, M. A., & Yates, E. A. (2005). Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Considerations for Surface Immobilisation of HS/Heparin Saccharides and Monitoring Their Interactions with Binding Proteins. In Chemistry and Biology of Heparin and Heparan Sulfate (pp. 345-366). Elsevier. doi:10.1016/b978-008044859-6/50013-7

DOI: 10.1016/b978-008044859-6/50013-7

Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein (Conference Paper)

Patey, S. J., Yates, E. A., & Turnbull, J. E. (2005). Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein. In S. J. Patey, E. A. yates, & J. E. Turnbull (Eds.), Biochemical Society Transactions Vol. 33 (pp. 1116-1118). X: Biochemical Society.

Novel heparan sulphate analogues:: inhibition of β-secretase cleavage of amyloid precursor protein (Journal article)

Patey, S. J., Yates, E. A., & Turnbull, J. E. (2005). Novel heparan sulphate analogues:: inhibition of β-secretase cleavage of amyloid precursor protein. BIOCHEMICAL SOCIETY TRANSACTIONS, 33, 1116-1118. doi:10.1042/BST0331116

DOI: 10.1042/BST0331116

Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein. (Conference Paper)

Patey, S. J., Yates, E. A., & Turnbull, J. E. (2005). Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein.. In Biochemical Society transactions Vol. 33 (pp. 1116-1118). doi:10.1042/bst20051116

DOI: 10.1042/bst20051116

Chapter 12 Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Considerations for Surface Immobilisation of HS/Heparin Saccharides and Monitoring Their Interactions with Binding Proteins (Chapter)

Rudd, T., Skidmore, M. A., & Yates, E. A. (2005). Chapter 12 Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Considerations for Surface Immobilisation of HS/Heparin Saccharides and Monitoring Their Interactions with Binding Proteins. In Chemistry and Biology of Heparin and Heparan Sulfate (pp. 345-366). Elsevier. doi:10.1016/b978-008044859-6/50013-7

DOI: 10.1016/b978-008044859-6/50013-7

Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Considerations for Surface Immobilisation of HS/Heparin Saccharides and Monitoring their Interactions with Binding Proteins (Chapter)

Rudd, T. R., Skidmore, M. A., & Yates, E. A. (2005). Surface-Based Studies of Heparin/Heparan Sulfate-Protein Interactions: Considerations for Surface Immobilisation of HS/Heparin Saccharides and Monitoring their Interactions with Binding Proteins. In H. G. Garg, R. J. Linhardt, & C. A. Hales (Eds.), Chemistry and Biology of Heparin and Heparan sulfate (pp. 1). New York: Elsevier.

2004

Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces (Journal article)

Skidmore, M. A., Patey, S. J., Thanh, N. T. K., Fernig, D. G., Turnbull, J. E., & Yates, E. A. (2004). Attachment of glycosaminoglycan oligosaccharides to thiol-derivatised gold surfaces. CHEMICAL COMMUNICATIONS, (23), 2700-2701. doi:10.1039/b411726c

DOI: 10.1039/b411726c

Highly diverse heparan sulfate analogue libraries: a novel resource for bioactivity screening of proteins (Journal article)

Guimond, S. E., Patey, S. J., Yates, E. A., & Turnbull, J. E. (2004). Highly diverse heparan sulfate analogue libraries: a novel resource for bioactivity screening of proteins. International Journal of Experimental Pathology, 85(4). doi:10.1111/j.0959-9673.2004.0390w.x

DOI: 10.1111/j.0959-9673.2004.0390w.x

Role of heparan sulfate in embryoid body formation (Journal article)

Drummond, K. J., Yates, E. A., Murray, P. A., & Turnbull, J. E. (2004). Role of heparan sulfate in embryoid body formation. International Journal of Experimental Pathology, 85(4). doi:10.1111/j.0959-9673.2004.0390t.x

DOI: 10.1111/j.0959-9673.2004.0390t.x

Interactions of heparin/heparan sulfate with proteins: Appraisal of structural factors and epxerimental approaches (Journal article)

Powell, A. K., Yates, E. A., Fernig, D. G., & Turnbull, J. E. (2004). Interactions of heparin/heparan sulfate with proteins: Appraisal of structural factors and epxerimental approaches. GLYCOBIOLOGY, 14(4), 17R-30R. doi:10.1093/glycob/cwh051

DOI: 10.1093/glycob/cwh051

Saccharide Libraries and Arrays (Patent)

Turnbull, J., Yates, E., & Powell, A. (2004). Saccharide Libraries and Arrays.

Highly Diverse Heparan Sulfate Analogue Libraries: Providing Access to Expanded Areas of Sequence Space for Bioactivity Screening (Journal article)

Yates, E. A., Guimond, S. E., & Turnbull, J. E. (2004). Highly Diverse Heparan Sulfate Analogue Libraries: Providing Access to Expanded Areas of Sequence Space for Bioactivity Screening. Journal of Medicinal Chemistry, 47(1), 277-280. doi:10.1021/jm0309755

DOI: 10.1021/jm0309755

Highly diverse heparan sulfate analogue libraries: Providing access to expanded areas of sequence space for bioactivity screening (Journal article)

Yates, E. A., Guimond, S. E., & Turnbull, J. E. (2004). Highly diverse heparan sulfate analogue libraries: Providing access to expanded areas of sequence space for bioactivity screening. JOURNAL OF MEDICINAL CHEMISTRY, 47(1), 277-280. doi:10.1021/jm0309755

DOI: 10.1021/jm0309755

2003

Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase (Journal article)

Scholefield, Z., Yates, E. A., Wayne, G., Amour, A., McDowell, W., & Turnbull, J. E. (2003). Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase. JOURNAL OF CELL BIOLOGY, 163(1), 97-107. doi:10.1083/jcb.200303059

DOI: 10.1083/jcb.200303059

Microwave enhanced reaction of carbohydrates with amino-derivatised labels and glass surfaces (Journal article)

Yates, E. A., Jones, M. O., Clarke, C. E., Powell, A. K., Johnson, S. R., Porch, A., . . . Turnbull, J. E. (2003). Microwave enhanced reaction of carbohydrates with amino-derivatised labels and glass surfaces. JOURNAL OF MATERIALS CHEMISTRY, 13(9), 2061-2063. doi:10.1039/b305248f

DOI: 10.1039/b305248f

Structural determinants of heparan sulphate modulation of GDNF signalling (Journal article)

Davies, J. A., Yates, E. A., & Turnbull, J. E. (2003). Structural determinants of heparan sulphate modulation of GDNF signalling. GROWTH FACTORS, 21(3-4), 109-119. doi:10.1080/08977190310001621005

DOI: 10.1080/08977190310001621005

Lactate carbon does not enter the sugars of lipopolysaccharide when gonococci are grown in a medium containing glucose and lactate: implications in vivo (Journal article)

Yates, E. A., & Smith, H. (2003). Lactate carbon does not enter the sugars of lipopolysaccharide when gonococci are grown in a medium containing glucose and lactate: implications in vivo. FEMS MICROBIOLOGY LETTERS, 218(2), 245-250. doi:10.1016/S0378-1097(02)011370

DOI: 10.1016/S0378-1097(02)011370

2002

N-acylhomoserine Lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa (Journal article)

Yates, E. A., Philipp, B., Buckley, C., Atkinson, S., Chhabra, S. R., Sockett, R. E., . . . Williams, P. (2002). N-acylhomoserine Lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa. INFECTION AND IMMUNITY, 70(10), 5635-5646. doi:10.1128/IAI.70.10.5635-5646.2002

DOI: 10.1128/IAI.70.10.5635-5646.2002

Heparan sulphate binds the aspartic protease β-Secretase and regulates cleavage of APP (Journal article)

Scholefield, Z., Wayne, G., Amour, A., Yates, E., McDowell, B., & Turnbull, J. (2002). Heparan sulphate binds the aspartic protease β-Secretase and regulates cleavage of APP. Biochemical Society Transactions, 30(3), A69. doi:10.1042/bst030a069c

DOI: 10.1042/bst030a069c

Heparan sulphate binds the aspartic protease β-secretase and regulates cleavage of APP (Journal article)

Scholefield, Z., Wayne, G., Amour, A., Yates, E., McDowell, B., & Turnbull, J. (2002). Heparan sulphate binds the aspartic protease β-secretase and regulates cleavage of APP. Biochemical Society Transactions, 30(3), A78. doi:10.1042/bst030a078c

DOI: 10.1042/bst030a078c

Saccharide Libraries (Journal article)

Turnbull, J. E., Powell, A., & Yates, E. A. (2002). Saccharide Libraries. Patent, UK Pat.

Specific heparan sulfate structures involved in retinal axon targeting (Journal article)

Irie, A., Yates, E. A., Turnbull, J. E., & Holt, C. E. (2002). Specific heparan sulfate structures involved in retinal axon targeting. DEVELOPMENT, 129(1), 61-70. Retrieved from https://www.webofscience.com/

2001

Lactate stimulation of gonococcal metabolism in media containing glucose: Mechanism, impact on pathogenicity, and wider implications for other pathogens (Journal article)

Smith, H., Yates, E. A., Cole, J. A., & Parsons, N. J. (2001). Lactate stimulation of gonococcal metabolism in media containing glucose: Mechanism, impact on pathogenicity, and wider implications for other pathogens. INFECTION AND IMMUNITY, 69(11), 6565-6572. doi:10.1128/IAI.69.11.6565-6572.2001

DOI: 10.1128/IAI.69.11.6565-6572.2001

Electrophoretic sequencing of heparin/heparan sulfate oligosaccharides using a highly sensitive fluorescent end label (Journal article)

Drummond, K. J., Yates, E. A., & Turnbull, J. E. (2001). Electrophoretic sequencing of heparin/heparan sulfate oligosaccharides using a highly sensitive fluorescent end label. PROTEOMICS, 1(2), 304-310. doi:3.3.CO;2-2">10.1002/1615-9861(200102)1:2<304::AID-PROT304>3.3.CO;2-2

DOI: 10.1002/1615-9861(200102)1:2<304::AID-PROT304>3.3.CO;2-2

Electrophoretic sequencing of heparin/heparan sulfate oligosaccharides using a highly sensitive fluorescent end label (Journal article)

Drummond, K. J., Yates, E. A., & Turnbull, J. E. (2001). Electrophoretic sequencing of heparin/heparan sulfate oligosaccharides using a highly sensitive fluorescent end label. PROTEOMICS, 1(2), 304-310. doi:3.0.co;2-b">10.1002/1615-9861(200102)1:2<304::aid-prot304>3.0.co;2-b

DOI: 10.1002/1615-9861(200102)1:2<304::aid-prot304>3.0.co;2-b

2000

Effect of substitution pattern on 1H, 13C NMR chemical shifts and 1JCH coupling constants in heparin derivatives (Journal article)

Yates, E. A., Santini, F., De Cristofano, B., Payre, N., Cosentino, C., Guerrini, M., . . . Hricovini, M. (2000). Effect of substitution pattern on 1H, 13C NMR chemical shifts and 1JCH coupling constants in heparin derivatives. CARBOHYDRATE RESEARCH, 329(1), 239-247. doi:10.1016/S0008-6215(00)00144-0

DOI: 10.1016/S0008-6215(00)00144-0

In a medium containing glucose, lactate carbon is incorporated by gonococci predominantly into fatty acids and glucose carbon incorporation is increased (Journal article)

Yates, E. A., Gao, L., Woodcock, N., Parsons, N., Cole, J., & Smith, H. (2000). In a medium containing glucose, lactate carbon is incorporated by gonococci predominantly into fatty acids and glucose carbon incorporation is increased. Int.J.Med.Microbiol.,, 290, 627-639.

In a medium containing glucose, lactate carbon is incorporated by gonococci predominantly into fatty acids and glucose carbon incorporation is increased: implications regarding lactate stimulation of metabolism (Journal article)

Yates, E., Gao, L. H., Woodcock, N., Parsons, N., Cole, J., & Smith, H. (2000). In a medium containing glucose, lactate carbon is incorporated by gonococci predominantly into fatty acids and glucose carbon incorporation is increased: implications regarding lactate stimulation of metabolism. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 290(7), 627-639. Retrieved from https://www.webofscience.com/

1999

Introduction of a nitrogen heterocycle into sulphated chitosan oligomers (Journal article)

Santini, F., Crini, G., Cosentino, C., Sturiale, L., & Yates, E. A. (1999). Introduction of a nitrogen heterocycle into sulphated chitosan oligomers. JOURNAL OF CARBOHYDRATE CHEMISTRY, 18(1), 105-111. doi:10.1080/07328309908543983

DOI: 10.1080/07328309908543983

1997

Modifications under basic conditions of the minor sequences of heparin containing 2,3 or 2,3,6 sulfated D-glucosamine residues (Journal article)

Santini, F., Bisio, A., Guerrini, M., & Yates, E. A. (1997). Modifications under basic conditions of the minor sequences of heparin containing 2,3 or 2,3,6 sulfated D-glucosamine residues. CARBOHYDRATE RESEARCH, 302(1-2), 103-108. doi:10.1016/S0008-6215(97)00111-0

DOI: 10.1016/S0008-6215(97)00111-0

Evidence for a heparin derivative containing an N-sulfated aziridine ring that retains high anti-factor Xa activity (Journal article)

Yates, E. A., Santini, F., Bisio, A., & Cosentino, C. (1997). Evidence for a heparin derivative containing an N-sulfated aziridine ring that retains high anti-factor Xa activity. CARBOHYDRATE RESEARCH, 298(4), 335-340. doi:10.1016/S0008-6215(96)00327-8

DOI: 10.1016/S0008-6215(96)00327-8

A heparin derivative containing an unusual N-sulphated aziridine group retains high anti factor-Xa activity (Journal article)

Yates, E. A., Santini, F., Bisio, A., & Cosentino, C. (1997). A heparin derivative containing an unusual N-sulphated aziridine group retains high anti factor-Xa activity. Carbohydr.Res.,, 335-340.

1996

1H and 13C NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives. (Journal article)

Yates, E. A., Santini, F., Guerrini, M., Naggi, A., Torri, G., & Casu, B. (1996). 1H and 13C NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives.. Carbohydrate research, 294, 15-27. doi:10.1016/s0008-6215(96)90611-4

DOI: 10.1016/s0008-6215(96)90611-4

1-H and 13-C NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives (Journal article)

Yates, E. A., Santini, F., Guerrini, M., Naggi, A., Torri, G., & Casu, B. (1996). 1-H and 13-C NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives. Carbohydr. Res.,, 294, 15-27.

Characterization of carbohydrate structural features recognized by anti-arabinogalactan-protein monoclonal antibodies (Journal article)

Yates, E. A., Valdor, J. F., Haslam, S. M., Morris, H. R., Dell, A., Mackie, W., & Knox, J. P. (1996). Characterization of carbohydrate structural features recognized by anti-arabinogalactan-protein monoclonal antibodies. GLYCOBIOLOGY, 6(2), 131-139. doi:10.1093/glycob/6.2.131

DOI: 10.1093/glycob/6.2.131

H-1 and C-13 NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives (Journal article)

Yates, E. A., Santini, F., Guerrini, M., Naggi, A., Torri, G., & Casu, B. (1996). H-1 and C-13 NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives. CARBOHYDRATE RESEARCH, 294, 15-27. Retrieved from https://www.webofscience.com/

Immunochemical comparison of membrane-associated and secreted arabinogalactan-proteins in rice and carrot (Journal article)

Smallwood, M., Yates, E. A., Willats, W. G. T., Martin, H., & Knox, J. P. (1996). Immunochemical comparison of membrane-associated and secreted arabinogalactan-proteins in rice and carrot. PLANTA, 198(3), 452-459. doi:10.1007/BF00620063

DOI: 10.1007/BF00620063

1995

ChemInform Abstract: Structural Studies of O‐Sulfated D‐Glucosamines. The Crystal and Molecular Structures of 2‐Amino‐2‐deoxy‐α/β‐D‐glucopyranose 3‐Sulfate (Free Acid) and 2‐Amino‐2‐deoxy‐β‐D‐glucopyranose 6‐ Sulfate (Free Base). (Journal article)

MACKIE, W., YATES, E. A., & LAMBA, D. (1995). ChemInform Abstract: Structural Studies of O‐Sulfated D‐Glucosamines. The Crystal and Molecular Structures of 2‐Amino‐2‐deoxy‐α/β‐D‐glucopyranose 3‐Sulfate (Free Acid) and 2‐Amino‐2‐deoxy‐β‐D‐glucopyranose 6‐ Sulfate (Free Base).. ChemInform, 26(21). doi:10.1002/chin.199521251

DOI: 10.1002/chin.199521251

STRUCTURAL STUDIES OF O-SULFATED D-GLUCOSAMINES - THE CRYSTAL AND MOLECULAR-STRUCTURES OF 2-AMINO-2-DEOXY-ALPHA/BETA-D-GLUCOPYRANOSE 3-SULFATE (FREE ACID) AND 2-AMINO-2-DEOXY-BETA-D-GLUCOPYRANOSE 6-SULFATE (FREE-BASE) (Journal article)

MACKIE, W., YATES, E. A., & LAMBA, D. (1995). STRUCTURAL STUDIES OF O-SULFATED D-GLUCOSAMINES - THE CRYSTAL AND MOLECULAR-STRUCTURES OF 2-AMINO-2-DEOXY-ALPHA/BETA-D-GLUCOPYRANOSE 3-SULFATE (FREE ACID) AND 2-AMINO-2-DEOXY-BETA-D-GLUCOPYRANOSE 6-SULFATE (FREE-BASE). CARBOHYDRATE RESEARCH, 266(1), 65-74. doi:10.1016/0008-6215(94)00248-E

DOI: 10.1016/0008-6215(94)00248-E

THE CRYSTAL AND MOLECULAR-STRUCTURE OF 2-SULFAMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSE SODIUM SALT-CENTER-DOT-2H(2)O (GLUCOSAMINE 2-SULFATE) (Journal article)

YATES, E. A., MACKIE, W., & LAMBA, D. (1995). THE CRYSTAL AND MOLECULAR-STRUCTURE OF 2-SULFAMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSE SODIUM SALT-CENTER-DOT-2H(2)O (GLUCOSAMINE 2-SULFATE). INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 17(3-4), 219-226. doi:10.1016/0141-8130(95)92689-N

DOI: 10.1016/0141-8130(95)92689-N

The crystal and molecular structure of 2-deoxy-2-amino-alpha D-glucopyranose (sodium sulphate) 2H2O (Journal article)

Yates, E. A., Lamba, D., & Mackie, W. (1995). The crystal and molecular structure of 2-deoxy-2-amino-alpha D-glucopyranose (sodium sulphate) 2H2O. Int. J. Biol. Macromol.,, 17, 219-226.

The crystal and molecular structures of 2-amino- alpha/beta D-glucopyranose 3-sulphate free acid and 2-amino-2-deoxy-beta-D-glucopyranose 6-sulphate free base (Journal article)

Mackie, W., Yates, E. A., & Lamba, D. (1995). The crystal and molecular structures of 2-amino- alpha/beta D-glucopyranose 3-sulphate free acid and 2-amino-2-deoxy-beta-D-glucopyranose 6-sulphate free base. Carbohydrate Research, 266, 65-74.

1994

INVESTIGATIONS INTO THE OCCURRENCE OF PLANT-CELL SURFACE EPITOPES IN EXUDATE GUMS (Journal article)

YATES, E. A., & KNOX, J. P. (1994). INVESTIGATIONS INTO THE OCCURRENCE OF PLANT-CELL SURFACE EPITOPES IN EXUDATE GUMS. CARBOHYDRATE POLYMERS, 24(4), 281-286. doi:10.1016/0144-8617(94)90072-8

DOI: 10.1016/0144-8617(94)90072-8

1993

SYNTHESIS AND X-RAY CRYSTALLOGRAPHIC STRUCTURE DETERMINATION OF METHYL ALPHA-D-GALACTOPYRANOSIDE 2,6-BIS(SODIUM SULFATE).2H2O (Journal article)

LAMBA, D., MACKIE, W., RASHID, A., SHELDRICK, B., & YATES, E. A. (1993). SYNTHESIS AND X-RAY CRYSTALLOGRAPHIC STRUCTURE DETERMINATION OF METHYL ALPHA-D-GALACTOPYRANOSIDE 2,6-BIS(SODIUM SULFATE).2H2O. CARBOHYDRATE RESEARCH, 241, 89-98. doi:10.1016/0008-6215(93)80098-Y

DOI: 10.1016/0008-6215(93)80098-Y

Synthetic and structural studies of sulphated carbohydrates (Thesis / Dissertation)

Yates, E. A. (1993). Synthetic and structural studies of sulphated carbohydrates. (PhD Thesis, The University of Leeds).

Publications

2023

Convenient syntheses of <i>trans</i>-resveratrol 3-<i>O</i> and 4′-<i>O</i>-β-<scp>d</scp>-glucuronides and a study of their aqueous stability (Journal article)

History and Prospects for the Sustainability and Circularity of the Windowpane Oyster Placuna placenta Fishery in the Philippines (Journal article)

Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells. (Journal article)

History and Prospects for Sustainability and Circularity of the Windowpane Oyster Placuna placenta Fishery in the Philippines (Preprint)

Low sulfated heparan sulfate mimetic differentially affects repair in immune-mediated and toxin-induced experimental models of demyelination (Journal article)

Heparin in Acid and Alkaline Environments—A Study of the Correlations between Hydrodynamic Properties and Desulphation (Journal article)

Monitoring the stability of heparin: NMR evidence for the rearrangement of sulfated iduronate in phosphate buffer (Journal article)

Functions and specificity of bacterial carbohydrate sulfatases targeting host glycans (Journal article)

Analysis of Heparin Samples by Attenuated Total Reflectance Fourier-Transform Infrared Spectroscopy in the Solid State (Journal article)

High sensitivity (zeptomole) detection of BODIPY-labelled heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts (Journal article)

Validation of Recombinant Heparan Sulphate Reagents for CNS Repair (Journal article)

A sulphated glycosaminoglycan extract from<i> Placopecten</i><i> magellanicus</i> inhibits the Alzheimer's disease 0-site amyloid precursor protein cleaving enzyme 1 (BACE-1) (Journal article)

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors (Journal article)

Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans (Journal article)

2022

Heparin Protects Human Neural Progenitor Cells from Zika Virus-Induced Cell Death While Preserving Their Differentiation into Mature Neuroglial Cells (Journal article)

Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota (vol 18, pg 841, 2022) (Journal article)

Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans (Preprint)

Phosphorylation and sulfation share a common biosynthetic pathway, but extend biochemical and evolutionary diversity of biological macromolecules in distinct ways (Journal article)

Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota (Journal article)

Using NMR to Dissect the Chemical Space and O-Sulfation Effects within the <i>O</i>- and <i>S</i>-Glycoside Analogues of Heparan Sulfate (Journal article)

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread non-receptor mediated immune cell recruitment (Preprint)

Pentosan Polysulfate Inhibits Attachment and Infection by SARS-CoV-2 In Vitro: Insights into Structural Requirements for Binding (Journal article)

NMR spectroscopy and chemometric models to detect a specific non-porcine ruminant contaminant in pharmaceutical heparin. (Journal article)

Initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans involves multiple binding modes (Preprint)

Analysis of protein-heparin interactions using a portable SPR instrument (Journal article)

Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars (Journal article)

Structural variation in the linkage region of pharmaceutical heparin arising from oxidative treatments during manufacture. (Journal article)

Synthetic Heparan Sulfate Mimetic Pixatimod (PG545) Potently Inhibits SARS-CoV-2 by Disrupting the Spike–ACE2 Interaction (Journal article)

Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars (Preprint)

2021

Pentosan polysulfate inhibits attachment and infection by SARS-CoV-2 <i>in vitro</i>: insights into structural requirements for binding (Preprint)

Anion binding to a cationic europium(iii) probe enables the first real-time assay of heparan sulfotransferase activity (Journal article)

Glycation of Host Proteins Increases Pathogenic Potential of <i>Porphyromonas gingivalis</i> (Journal article)

A single sulfatase is required to access colonic mucin by a gut bacterium (Journal article)

Chemical Modification of Glycosaminoglycan Polysaccharides (Journal article)

Endocytosis and the Participation of Glycosaminoglycans Are Important to the Mechanism of Cell Death Induced by β-Hairpin Antimicrobial Peptides (Journal article)

Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota (Preprint)

Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota (Preprint)

Heparin protects human neural progenitor cells from Zika Virus-induced cell death and preserves their differentiation into mature neural-glia cells (Preprint)

Glycosaminoglycans from <i>Litopenaeus vannamei</i> Inhibit the Alzheimer's Disease β Secretase, BACE1 (Journal article)

ER-Golgi dynamics of HS-modifying enzymes via vesicular trafficking is a critical prerequisite for the delineation of HS biosynthesis (Journal article)

Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity (Journal article)

Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity (vol 478, pg 735, 2021) (Journal article)

Hydrolytic Degradation of Heparin in Acidic Environments: Nuclear Magnetic Resonance Reveals Details of Selective Desulfation (Journal article)

Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations (Journal article)

A single bacterial sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium (Preprint)

A Review of the Distribution, Botany, Phytochemistry and Biological Activity of Dioscorine From <i>Dioscorea hispida</i> (Journal article)

Synthesis and toxicity profile in 293 human embryonic kidney cells of the β D-glucuronide derivatives of <i>ortho</i>-<i>, meta</i>- and <i>para</i>-cresol (Journal article)

2020

Extracellular histones stimulate collagen expression <i>in vitro</i> and promote liver fibrogenesis in a mouse model <i>via </i>the TLR4-MyD88 signaling pathway (Journal article)

Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity (Journal article)

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin (Journal article)

A single bacterial sulfatase is required for metabolism of colonic mucin <i>O</i>-glycans and intestinal colonization by a symbiotic human gut bacterium (Preprint)

Aggregation Kinetics and Filament Structure of a Tau Fragment Are Influenced by the Sulfation Pattern of the Cofactor Heparin (Journal article)

Should We Be Worried About <i>Clostridioides difficile</i> During the SARS-CoV2 Pandemic? (Journal article)

Extracellular histones stimulate collagen expression and potentially promote liver fibrogenesis via TLR4-MyD88 signalling pathway (Preprint)

Metabolism of multiple glycosaminoglycans by <i>Bacteroides thetaiotaomicron</i> is orchestrated by a versatile core genetic locus (vol 11, 646, 2020) (Journal article)

Unfractionated heparin inhibits live wild-type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations. (Preprint)

Glycosaminoglycans induce conformational change in the SARS-CoV-2 Spike S1 Receptor Binding Domain (Journal article)

SARS-CoV-2 Spike S1 Receptor Binding Domain undergoes Conformational Change upon Interaction with Low Molecular Weight Heparins (Journal article)

Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin (Journal article)

Interaction with the heparin-derived binding inhibitors destabilizes galectin-3 protein structure (Journal article)

The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding (Journal article)

Editorial: Heparan Sulfate Proteoglycans and Their Endogenous Modifying Enzymes: Cancer Players, Biomarkers and Therapeutic Targets (Journal article)

Metabolism of multiple glycosaminoglycans by Bacteroides thetaiotaomicron is orchestrated by a versatile core genetic locus (Journal article)

Heparan sulfate structure is influenced by the ER-Golgi dynamics of its modifying enzymes (Preprint)

High sensitivity (zeptomole) detection of BODIPY heparan sulfate (HS) disaccharides by ion-paired RP-HPLC and LIF detection enables analysis of HS from mosquito midguts (Journal article)

SimpleDSFviewer: A tool to analyze and view differential scanning fluorimetry data for characterizing protein thermal stability and interactions (Journal article)

2019

A further unique chondroitin sulfate from the shrimp <i>Litopenaeus vannamei</i> with antithrombin activity that modulates acute inflammation (Journal article)

Tools for the Quality Control of Pharmaceutical Heparin (Journal article)

The use of ATR-FTIR spectroscopy to characterise crude heparin samples by composition and structural features (Preprint)

Multivariate analysis applied to complex biological medicines (Journal article)

Intrinsic tryptophan fluorescence spectroscopy reliably determines galectin-ligand interactions (Journal article)

Sulfated polysaccharides interact with fibroblast growth factors and protect from denaturation (Journal article)

A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease (Journal article)

Inhibition of BACE1, the beta-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus (Journal article)