Photo of Professor Caroline Dart

Professor Caroline Dart BSc, DPhil (Oxon)

Professor Molecular & Physiology Cell Signalling

    Publications

    Selected Publications

    1. Soluble adenylyl cyclase links Ca2+ entry to Ca2+/cAMP-response element binding protein (CREB) activation in vascular smooth muscle (Journal article - 2019)
    2. Calcium/calmodulin-dependent kinase 2 mediates Epac-induced spontaneous transient outward currents in rat vascular smooth muscle (Journal article - 2017)
    3. Exchange protein activated by cAMP (Epac) induces vascular relaxation by activating Ca2+-sensitive K+ channels in rat mesenteric artery (Journal article - 2013)
    4. Interaction with caveolin-1 modulates vascular ATP-sensitive potassium (K(ATP)) channel activity (Journal article - 2010)
    5. Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels (Journal article - 2004)

    2020

    Hypoxia and metabolic inhibitors alter the intracellular ATP:ADP ratio and membrane potential in human coronary artery smooth muscle cells. (Journal article)

    Yang, M., Dart, C., Kamishima, T., & Quayle, J. M. (2020). Hypoxia and metabolic inhibitors alter the intracellular ATP:ADP ratio and membrane potential in human coronary artery smooth muscle cells.. PeerJ, 8, e10344. doi:10.7717/peerj.10344

    DOI: 10.7717/peerj.10344

    Calcium Store-Operated Currents in Human Skin Cells (Conference Paper)

    Manning, D., Evans, R. L., & Dart, C. (2020). Calcium Store-Operated Currents in Human Skin Cells. In BIOPHYSICAL JOURNAL Vol. 118 (pp. 563A). Retrieved from http://gateway.webofknowledge.com/

    LQTS-Associated Mutants of Calmodulin Show Disrupted Interaction with L-Type Calcium Channels (Conference Paper)

    Gupta, N., McCormick, L. F., Haynes, L. P., Dart, C., & Helassa, N. (2020). LQTS-Associated Mutants of Calmodulin Show Disrupted Interaction with L-Type Calcium Channels. In BIOPHYSICAL JOURNAL Vol. 118 (pp. 405A). Retrieved from http://gateway.webofknowledge.com/

    Long-QT Syndrome-Associated Calmodulin Mutations and Their Interactions at the K(v)7.1 Potassium Channel (Conference Paper)

    McCormick, L. F., Gupta, N., Haynes, L. P., Antonyuk, S., Dart, C., & Helassa, N. (2020). Long-QT Syndrome-Associated Calmodulin Mutations and Their Interactions at the K(v)7.1 Potassium Channel. In BIOPHYSICAL JOURNAL Vol. 118 (pp. 404A). Retrieved from http://gateway.webofknowledge.com/

    Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data (Journal article)

    Celik, N., O’Brien, F., Brennan, S., Rainbow, R. D., Dart, C., Zheng, Y., . . . Barrett-Jolley, R. (2020). Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data. Communications Biology, 3, 1-10. doi:10.1038/s42003-019-0729-3

    DOI: 10.1038/s42003-019-0729-3

    2019

    Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data (Journal article)

    Celik, N., O’Brien, F., Brennan, S., Rainbow, R., Dart, C., Zheng, Y., . . . Barrett-Jolley, R. (n.d.). Deep-Channel uses deep neural networks to detect single-molecule events from patch-clamp data. BioRxiv. doi:10.1101/767418

    DOI: 10.1101/767418

    Soluble adenylyl cyclase links Ca2+ entry to Ca2+/cAMP-response element binding protein (CREB) activation in vascular smooth muscle (Journal article)

    Parker, T., Wang, K. -W., Manning, D., & Dart, C. (2019). Soluble adenylyl cyclase links Ca2+ entry to Ca2+/cAMP-response element binding protein (CREB) activation in vascular smooth muscle. Scientific Reports, 9. doi:10.1038/s41598-019-43821-3

    DOI: 10.1038/s41598-019-43821-3

    2017

    Calcium/calmodulin-dependent kinase 2 mediates Epac-induced spontaneous transient outward currents in rat vascular smooth muscle (Journal article)

    Humphries, E. S. A., Kamishima, T., Quayle, J. M., & Dart, C. (2017). Calcium/calmodulin-dependent kinase 2 mediates Epac-induced spontaneous transient outward currents in rat vascular smooth muscle. The Journal of Physiology, 595(18), 6147-6164. doi:10.1113/JP274754

    DOI: 10.1113/JP274754

    Bioenergetic profile of human coronary artery smooth muscle cells and effect of metabolic intervention (Journal article)

    Yang, M., Chadwick, A., Dart, C., Kamishima, T., & Quayle, J. (2017). Bioenergetic profile of human coronary artery smooth muscle cells and effect of metabolic intervention. PLoS One, 12(5). doi:10.1371/journal.pone.0177951

    DOI: 10.1371/journal.pone.0177951

    2016

    Activation of calcium/calmodulin-dependent kinase 2 (CaMKII) mediates Epac-induced increases in spontaneous transient outward current in rat mesenteric artery smooth muscle (Conference Paper)

    Humphries, E. S. A., Kamishima, T., Quayle, J. M., & Dart, C. (2016). Activation of calcium/calmodulin-dependent kinase 2 (CaMKII) mediates Epac-induced increases in spontaneous transient outward current in rat mesenteric artery smooth muscle. In Proceedings of the Physiological Society Vol. PCB313. Dublin, Ireland.

    Epac-mediated Vasorelaxation: Epac Increases Spontaneous Transient Outward Current (STOC) In Mesenteric Artery Smooth Muscle Via Activation Of CAMKII (Conference Paper)

    Dart, C., & Humphries, E. S. A. (2016). Epac-mediated Vasorelaxation: Epac Increases Spontaneous Transient Outward Current (STOC) In Mesenteric Artery Smooth Muscle Via Activation Of CAMKII. In FASEB JOURNAL Vol. 30. Retrieved from http://gateway.webofknowledge.com/

    2015

    Caveolar disruption causes contraction of rat femoral arteries via reduced basal NO release and subsequent closure of BKCa channels (Journal article)

    Al-Brakati, A. Y., Kamishima, T., Dart, C., & Quayle, J. M. (2015). Caveolar disruption causes contraction of rat femoral arteries via reduced basal NO release and subsequent closure of BKCa channels. PEERJ, 3. doi:10.7717/peerj.966

    DOI: 10.7717/peerj.966

    Oxygen regulation of human coronary artery smooth muscle cell proliferation and migration (Conference Paper)

    Yang, M. M., Kamishima, T., Dart, C., & Quayle, J. M. (2015). Oxygen regulation of human coronary artery smooth muscle cell proliferation and migration. In Arteriosclerosis, Thrombosis, and Vascular Biology Vol. 35. San Francisco.

    The effects of hypoxia and metabolic inhibitors on cellular ATP and ATP/ADP ratio in human coronary artery smooth muscle cells (Conference Paper)

    Yang, M. M., Kamishima, T., Roberts, O. L. L., Dart, C., & Quayle, J. M. (2015). The effects of hypoxia and metabolic inhibitors on cellular ATP and ATP/ADP ratio in human coronary artery smooth muscle cells. In Arteriosclerosis Thrombosis and Vascular Biology Vol. 35. San Francisco: Lippincott Williams & Wilkins Ltd..

    TRPV4 and KCa functionally couple as osmosensors in the PVN (Journal article)

    Feetham, C., Nunn, N., Lewis, R., Dart, C., & Barrett-Jolley, R. (2015). TRPV4 and KCa functionally couple as osmosensors in the PVN. British Journal of Pharmacology, 172(7), 1753-1768. doi:10.1111/bph.13023

    DOI: 10.1111/bph.13023

    Neuronal and Cardiovascular Potassium Channels as Therapeutic Drug Targets: Promise and Pitfalls (Journal article)

    Humphries, E. S. A., & Dart, C. (2015). Neuronal and Cardiovascular Potassium Channels as Therapeutic Drug Targets: Promise and Pitfalls. JOURNAL OF BIOMOLECULAR SCREENING, 20(9), 1055-1073. doi:10.1177/1087057115601677

    DOI: 10.1177/1087057115601677

    2014

    cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP) (Journal article)

    Roberts, O. L., & Dart, C. (2014). cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP). BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 89-97. doi:10.1042/BST20130253

    DOI: 10.1042/BST20130253

    Caveolae as specialized lipid rafts: Diverse roles in the regulation of potassium channel signalling (Chapter)

    Byrne, D., & Dart, C. (2014). Caveolae as specialized lipid rafts: Diverse roles in the regulation of potassium channel signalling. In Lipid Rafts: Properties, Controversies and Roles in Signal Transduction (pp. 53-68).

    Verdict in the Smooth Muscle K-ATP Channel Case Guilty of Blood Pressure Control But Innocent of Sudden Death Phenotype (Journal article)

    Dart, C. (2014). Verdict in the Smooth Muscle K-ATP Channel Case Guilty of Blood Pressure Control But Innocent of Sudden Death Phenotype. HYPERTENSION, 64(3), 457-458. doi:10.1161/HYPERTENSIONAHA.114.03289

    DOI: 10.1161/HYPERTENSIONAHA.114.03289

    2013

    Exchange protein activated by cAMP (Epac) induces vascular relaxation by activating Ca2+-sensitive K+ channels in rat mesenteric artery (Journal article)

    Roberts, O. L., Kamishima, T., Barrett-Jolley, R., Quayle, J. M., & Dart, C. (2013). Exchange protein activated by cAMP (Epac) induces vascular relaxation by activating Ca2+-sensitive K+ channels in rat mesenteric artery. JOURNAL OF PHYSIOLOGY-LONDON, 591(20), 5107-5123. doi:10.1113/jphysiol.2013.262006

    DOI: 10.1113/jphysiol.2013.262006

    Human CRP Defends against the Toxicity of Circulating Histones (Journal article)

    Abrams, S. T., Zhang, N., Dart, C., Wang, S. S., Thachil, J., Guan, Y., . . . Toh, C. -H. (2013). Human CRP Defends against the Toxicity of Circulating Histones. JOURNAL OF IMMUNOLOGY, 191(5), 2495-2502. doi:10.4049/jimmunol.1203181

    DOI: 10.4049/jimmunol.1203181

    Effect of the Epac activator 8-pCPT-2 '-O-Me-cAMP (8-pCPT) on the expression pattern of VE-cadherin (VE-cad) & connexins (Cxs) in Human Coronary Artery Endothelial Cells (HCAECs) (Conference Paper)

    Quinn, R. E., Roberts, O., Kamishima, T., Dart, C., & Quayle, J. (2013). Effect of the Epac activator 8-pCPT-2 '-O-Me-cAMP (8-pCPT) on the expression pattern of VE-cadherin (VE-cad) & connexins (Cxs) in Human Coronary Artery Endothelial Cells (HCAECs). In FASEB JOURNAL Vol. 27. Retrieved from http://gateway.webofknowledge.com/

    Selective Activation of Epac Increases the Frequency of Submembrane Calcium Sparks in Mesenteric Smooth Muscle Cells (Conference Paper)

    Roberts, O. L., Kamishima, T., Barrett-Jolley, R., Quayle, J. M., & Dart, C. (2013). Selective Activation of Epac Increases the Frequency of Submembrane Calcium Sparks in Mesenteric Smooth Muscle Cells. In BIOPHYSICAL JOURNAL Vol. 104 (pp. 614A-615A). Retrieved from http://gateway.webofknowledge.com/

    Circulating Histones Are Mediators of Trauma-associated Lung Injury (Journal article)

    Abrams, S. T., Zhang, N., Manson, J., Liu, T., Dart, C., Baluwa, F., . . . Toh, C. -H. (2013). Circulating Histones Are Mediators of Trauma-associated Lung Injury. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 187(2), 160-169. doi:10.1164/rccm.201206-1037OC

    DOI: 10.1164/rccm.201206-1037OC

    Structural diversity of the cAMP-dependent protein kinase regulatory subunit in Caenorhabditis elegans (Journal article)

    Pastok, M. W., Prescott, M. C., Dart, C., Murray, P., Rees, H. H., & Fisher, M. J. (2013). Structural diversity of the cAMP-dependent protein kinase regulatory subunit in Caenorhabditis elegans. CELLULAR SIGNALLING, 25(1), 168-177. doi:10.1016/j.cellsig.2012.09.006

    DOI: 10.1016/j.cellsig.2012.09.006

    2012

    Potassium channels in articular chondrocytes (Journal article)

    Mobasheri, A., Lewis, R., Ferreira-Mendes, A., Rufino, A., Dart, C., & Barrett-Jolley, R. (2012). Potassium channels in articular chondrocytes. CHANNELS, 6(6), 416-425. doi:10.4161/chan.22340

    DOI: 10.4161/chan.22340

    Evaluating Caveolin Interactions: Do Proteins Interact with the Caveolin Scaffolding Domain through a Widespread Aromatic Residue-Rich Motif? (Journal article)

    Byrne, D. P., Dart, C., & Rigden, D. J. (2012). Evaluating Caveolin Interactions: Do Proteins Interact with the Caveolin Scaffolding Domain through a Widespread Aromatic Residue-Rich Motif?. PLOS ONE, 7(9). doi:10.1371/journal.pone.0044879

    DOI: 10.1371/journal.pone.0044879

    Selective block of KATP channels: why the anti-diabetic sulphonylureas and rosiglitazone have more in common than we thought (Journal article)

    Dart, C. (2012). Selective block of KATP channels: why the anti-diabetic sulphonylureas and rosiglitazone have more in common than we thought. BRITISH JOURNAL OF PHARMACOLOGY, 167(1), 23-25. doi:10.1111/j.1476-5381.2012.01990.x

    DOI: 10.1111/j.1476-5381.2012.01990.x

    Indirect Channel Regulation by Cholesterol: The Role of Caveolae and Caveolins in Regulating KATP Channel Function (Chapter)

    Dart, C. (n.d.). Indirect Channel Regulation by Cholesterol: The Role of Caveolae and Caveolins in Regulating KATP Channel Function. In Cholesterol Regulation of Ion Channels and Receptors (pp. 161-179). John Wiley & Sons, Inc.. doi:10.1002/9781118342312.ch8

    DOI: 10.1002/9781118342312.ch8

    2011

    The Role of the Membrane Potential in Chondrocyte Volume Regulation (Journal article)

    Lewis, R., Asplin, K. E., Bruce, G., Dart, C., Mobasheri, A., & Barrett-Jolley, R. (2011). The Role of the Membrane Potential in Chondrocyte Volume Regulation. JOURNAL OF CELLULAR PHYSIOLOGY, 226(11), 2979-2986. doi:10.1002/jcp.22646

    DOI: 10.1002/jcp.22646

    Function and Pharmacology of Spinally-Projecting Sympathetic Pre-Autonomic Neurones in the Paraventricular Nucleus of the Hypothalamus (Journal article)

    Nunn, N., Womack, M., Dart, C., & Barrett-Jolley, R. (2011). Function and Pharmacology of Spinally-Projecting Sympathetic Pre-Autonomic Neurones in the Paraventricular Nucleus of the Hypothalamus. CURRENT NEUROPHARMACOLOGY, 9(2), 262-277. Retrieved from http://gateway.webofknowledge.com/

    2010

    Interaction with caveolin-1 modulates vascular ATP-sensitive potassium (K(ATP)) channel activity (Journal article)

    Davies, L. M., Purves, G. I., Barrett-Jolley, R., & Dart, C. (2010). Interaction with caveolin-1 modulates vascular ATP-sensitive potassium (K(ATP)) channel activity. JOURNAL OF PHYSIOLOGY-LONDON, 588(17), 3254-3265. doi:10.1113/jphysiol.2010.194779

    DOI: 10.1113/jphysiol.2010.194779

    Lipid microdomains and the regulation of ion channel function (Journal article)

    Dart, C. (2010). Lipid microdomains and the regulation of ion channel function. JOURNAL OF PHYSIOLOGY-LONDON, 588(17), 3169-3178. doi:10.1113/jphysiol.2010.191585

    DOI: 10.1113/jphysiol.2010.191585

    Caveolin-1 Inhibits Vascular K-ATP Channels by Modulating Channel Sensitivity to MgADP (Conference Paper)

    Davies, L. M., Purves, G. I., Barrett-Jolley, R., & Dart, C. (2010). Caveolin-1 Inhibits Vascular K-ATP Channels by Modulating Channel Sensitivity to MgADP. In BIOPHYSICAL JOURNAL Vol. 98 (pp. 698A). doi:10.1016/j.bpj.2009.12.3830

    DOI: 10.1016/j.bpj.2009.12.3830

    Epac-Mediated Mobilization of Intracellular Calcium in Vascular Myocytes and the Downstream Effects on Arterial K-ATP Channels (Conference Paper)

    Purves, G. I., Kamishima, T., Davies, L. M., Quayle, J. M., & Dart, C. (2010). Epac-Mediated Mobilization of Intracellular Calcium in Vascular Myocytes and the Downstream Effects on Arterial K-ATP Channels. In BIOPHYSICAL JOURNAL Vol. 98 (pp. 138A). doi:10.1016/j.bpj.2009.12.743

    DOI: 10.1016/j.bpj.2009.12.743

    2009

    Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels (Journal article)

    Purves, G. I., Kamishima, T., Davies, L. M., Quayle, J. M., & Dart, C. (2009). Exchange protein activated by cAMP (Epac) mediates cAMP-dependent but protein kinase A-insensitive modulation of vascular ATP-sensitive potassium channels. JOURNAL OF PHYSIOLOGY-LONDON, 587(14), 3639-3650. doi:10.1113/jphysiol.2009.173534

    DOI: 10.1113/jphysiol.2009.173534

    2008

    Lipid microdomains and k(+) channel compartmentation: detergent and non-detergent-based methods for the isolation and characterisation of cholesterol-enriched lipid rafts. (Journal article)

    Sampson, L. J., & Dart, C. (2008). Lipid microdomains and k(+) channel compartmentation: detergent and non-detergent-based methods for the isolation and characterisation of cholesterol-enriched lipid rafts.. Methods in molecular biology (Clifton, N.J.), 491, 91-101. doi:10.1007/978-1-59745-526-8_7

    DOI: 10.1007/978-1-59745-526-8_7

    2007

    Small-angle X-ray scattering and NMR studies of the conformation of the PDZ region of SAP97 and its interactions with Kir2.1 (Journal article)

    Goult, B. T., Rapley, J. D., Dart, C., Kitmitto, A., Grossmann, J. G., Leyland, M. L., & Lian, L. -Y. (2007). Small-angle X-ray scattering and NMR studies of the conformation of the PDZ region of SAP97 and its interactions with Kir2.1. BIOCHEMISTRY, 46(49), 14117-14128. doi:10.1021/bi701257z

    DOI: 10.1021/bi701257z

    Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels (Journal article)

    Sampson, L. J., Davies, L. M., Barrett-Jolley, R., Standen, N. B., & Dart, C. (2007). Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels. CARDIOVASCULAR RESEARCH, 76(1), 61-70. doi:10.1016/j.cardiores.2007.05.020

    DOI: 10.1016/j.cardiores.2007.05.020

    Vasoconstrictor-induced targeting of PKC lsozymes to smooth muscle caveolae (Conference Paper)

    Sampson, L. J., Standen, N. B., & Dart, C. (2007). Vasoconstrictor-induced targeting of PKC lsozymes to smooth muscle caveolae. In BIOPHYSICAL JOURNAL (pp. 131A). Retrieved from http://gateway.webofknowledge.com/

    2005

    The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death (Journal article)

    Cao, J., Viholainen, J. I., Dart, C., Warwick, H. K., Leyland, M. L., & Courtney, M. J. (2005). The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death. JOURNAL OF CELL BIOLOGY, 168(1), 117-126. doi:10.1083/jcb.200407024

    DOI: 10.1083/jcb.200407024

    Activated protein kinase C epsilon localises to smooth muscle caveolae (Conference Paper)

    Sampson, L. J., Davis, A. J., Standen, N. B., & Dart, C. (2005). Activated protein kinase C epsilon localises to smooth muscle caveolae. In BIOPHYSICAL JOURNAL Vol. 88 (pp. 626A). Retrieved from http://gateway.webofknowledge.com/

    Identification of a binding site for the kinase-anchoring protein, AKAP79 on the inwardly rectifying potassium channel, Kir2.1. (Conference Paper)

    Davis, A. J., & Dart, C. (2005). Identification of a binding site for the kinase-anchoring protein, AKAP79 on the inwardly rectifying potassium channel, Kir2.1.. In BIOPHYSICAL JOURNAL Vol. 88 (pp. 106A). Retrieved from http://gateway.webofknowledge.com/

    2004

    Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels (Journal article)

    Sampson, L. J., Hayabuchi, Y., Standen, N. B., & Dart, C. (2004). Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels. CIRCULATION RESEARCH, 95(10), 1012-1018. doi:10.1161/01.RES.0000148634.47095.ab

    DOI: 10.1161/01.RES.0000148634.47095.ab

    An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1 (Journal article)

    Leyland, M. L., & Dart, C. (2004). An alternatively spliced isoform of PSD-93/chapsyn 110 binds to the inwardly rectifying potassium channel, Kir2.1. JOURNAL OF BIOLOGICAL CHEMISTRY, 279(42), 43427-43436. doi:10.1074/jbc.M407575200

    DOI: 10.1074/jbc.M407575200

    2003

    Direct interaction between the actin-binding protein filamin-A and the inwardly rectifying potassium channel, Kir2.1 (Journal article)

    Sampson, L. J., Leyland, M. L., & Dart, C. (2003). Direct interaction between the actin-binding protein filamin-A and the inwardly rectifying potassium channel, Kir2.1. JOURNAL OF BIOLOGICAL CHEMISTRY, 278(43), 41988-41997. doi:10.1074/jbc.M307479200

    DOI: 10.1074/jbc.M307479200

    Binding of a novel alternatively spliced isoform of PSD-93 to the inwardly rectiftying potassium channel Kir2.1 (Journal article)

    Leyland, M. L., & Dart, C. (2003). Binding of a novel alternatively spliced isoform of PSD-93 to the inwardly rectiftying potassium channel Kir2.1. BIOPHYSICAL JOURNAL, 84(2), 223A. Retrieved from http://gateway.webofknowledge.com/

    Identification of filamin-A as an interacting partner of inwardly rectifying potassium channel, Kir2.1 (Journal article)

    Sampson, L. J., Dart, C., & Leyland, M. L. (2003). Identification of filamin-A as an interacting partner of inwardly rectifying potassium channel, Kir2.1. BIOPHYSICAL JOURNAL, 84(2), 223A. Retrieved from http://gateway.webofknowledge.com/

    2002

    Interaction between inwardly rectifying potassium channel, Kir 2.1, and synapse-associated protein-97 in the porcine coronary artery (Journal article)

    Sampson, L. J., Dart, C., & Leyland, M. L. (2002). Interaction between inwardly rectifying potassium channel, Kir 2.1, and synapse-associated protein-97 in the porcine coronary artery. JOURNAL OF PHYSIOLOGY-LONDON, 544, 25P. Retrieved from http://gateway.webofknowledge.com/

    Effects of cortisol on neuronal excitability (Journal article)

    Zaki, A., Dart, C., & Barrett-Jolley, R. (2002). Effects of cortisol on neuronal excitability. BIOPHYSICAL JOURNAL, 82(1), 626A. Retrieved from http://gateway.webofknowledge.com/

    2001

    Evidence for involvement of A-kinase anchoring protein in activation of rat arterial K(ATP) channels by protein kinase A. (Journal article)

    Hayabuchi, Y., Dart, C., & Standen, N. B. (2001). Evidence for involvement of A-kinase anchoring protein in activation of rat arterial K(ATP) channels by protein kinase A.. J Physiol, 536(Pt 2), 421-427. doi:10.1111/j.1469-7793.2001.0421c.xd

    DOI: 10.1111/j.1469-7793.2001.0421c.xd

    Evidence for involvement of A-kinase anchoring protein in activation of rat arterial K-ATP channels by protein kinase A (Journal article)

    Hayabuchi, Y., Dart, C., & Standen, N. B. (2001). Evidence for involvement of A-kinase anchoring protein in activation of rat arterial K-ATP channels by protein kinase A. JOURNAL OF PHYSIOLOGY-LONDON, 536(2), 421-427. doi:10.1111/j.1469-7793.2001.0421c.xd

    DOI: 10.1111/j.1469-7793.2001.0421c.xd

    Targeting of an a kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1 (Journal article)

    Dart, C., & Leyland, M. L. (2001). Targeting of an a kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1. JOURNAL OF BIOLOGICAL CHEMISTRY, 276(23), 20499-20505. doi:10.1074/jbc.M101425200

    DOI: 10.1074/jbc.M101425200

    Targeting of an A-kinase anchoring protein, AKAP79, to an inwardly rectifying potassium channel, murine Kir2.1 (Journal article)

    Dart, C., & Leyland, M. L. (2001). Targeting of an A-kinase anchoring protein, AKAP79, to an inwardly rectifying potassium channel, murine Kir2.1. JOURNAL OF PHYSIOLOGY-LONDON, 533, 112P. Retrieved from http://gateway.webofknowledge.com/

    2000

    Studies of structure and function in inward rectifier potassium channels (Journal article)

    Abrams, C. J., Ashmole, I., Brammar, W. J., Conley, E. C., Dart, C., Davies, N. W., . . . Stanfield, P. R. (2000). Studies of structure and function in inward rectifier potassium channels. JOURNAL OF PHYSIOLOGY-LONDON, 523, 4S-5S. Retrieved from http://gateway.webofknowledge.com/

    Modelling the block of IRK1 channels by silver ions. (Conference Paper)

    Barrett-Jolley, R., & Dart, C. (2000). Modelling the block of IRK1 channels by silver ions.. In BIOPHYSICAL JOURNAL Vol. 78 (pp. 350A). Retrieved from http://gateway.webofknowledge.com/

    1999

    Direct block of native and cloned (Kir2.1) inward rectifier K+ channels by chloroethylclonidine (Journal article)

    Barrett-Jolley, R., Dart, C., & Standen, N. B. (1999). Direct block of native and cloned (Kir2.1) inward rectifier K+ channels by chloroethylclonidine. BRITISH JOURNAL OF PHARMACOLOGY, 128(3), 760-766. doi:10.1038/sj.bjp.0702819

    DOI: 10.1038/sj.bjp.0702819

    The possible role of a disulphide bond in forming functional Kir2.1 potassium channels (Journal article)

    Leyland, M. L., Dart, C., Spencer, P. J., Sutcliffe, M. J., & Stanfield, P. R. (1999). The possible role of a disulphide bond in forming functional Kir2.1 potassium channels. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 438(6), 778-781. doi:10.1007/s004240051106

    DOI: 10.1007/s004240051106

    Topology of the pore region of an inward rectifier K+ channel, Kir2.1 (Conference Paper)

    Dart, C., Leyland, M. L., Spencer, P. J., Stanfield, P. R., & Sutcliffe, M. J. (1999). Topology of the pore region of an inward rectifier K+ channel, Kir2.1. In MOLECULAR AND FUNCTIONAL DIVERSITY OF ION CHANNELS AND RECEPTORS Vol. 868 (pp. 414-417). doi:10.1111/j.1749-6632.1999.tb11303.x

    DOI: 10.1111/j.1749-6632.1999.tb11303.x

    1998

    The dependence of Ag+ block of a potassium channel, murine Kir2.1, on a cysteine residue in the selectivity filter (Journal article)

    Dart, C., Leyland, M. L., Barrett-Jolley, R., Shelton, P. A., Spencer, P. J., Conley, E. C., . . . Stanfield, P. R. (1998). The dependence of Ag+ block of a potassium channel, murine Kir2.1, on a cysteine residue in the selectivity filter. JOURNAL OF PHYSIOLOGY-LONDON, 511(1), 15-24. doi:10.1111/j.1469-7793.1998.015bi.x

    DOI: 10.1111/j.1469-7793.1998.015bi.x

    The selectivity filter of a potassium channel, murine Kir2.1, investigated using scanning cysteine mutagenesis (Journal article)

    Dart, C., Leyland, M. L., Spencer, P. J., Stanfield, P. R., & Sutcliffe, M. J. (1998). The selectivity filter of a potassium channel, murine Kir2.1, investigated using scanning cysteine mutagenesis. JOURNAL OF PHYSIOLOGY-LONDON, 511(1), 25-32. doi:10.1111/j.1469-7793.1998.025bi.x

    DOI: 10.1111/j.1469-7793.1998.025bi.x

    1997

    Possible topology of the H5 region of an inward rectifier K+ channel, murine IRK1. (Journal article)

    Dart, C., Leyland, M. L., Spencer, P. J., Conley, E. C., Stanfield, P. R., & Sutcliffe, M. J. (1997). Possible topology of the H5 region of an inward rectifier K+ channel, murine IRK1.. JOURNAL OF PHYSIOLOGY-LONDON, 504P, P155. Retrieved from http://gateway.webofknowledge.com/

    Block of inward rectifier IRK1 by sulfhydryl-specific reagents (Conference Paper)

    Dart, C., Leyland, M. L., BarrettJolley, R., & Stanfield, P. R. (1997). Block of inward rectifier IRK1 by sulfhydryl-specific reagents. In BIOPHYSICAL JOURNAL Vol. 72 (pp. WPO33). Retrieved from http://gateway.webofknowledge.com/

    Single subunit mutations of the murine K+ channel IRK1 (Journal article)

    Leyland, M. L., Shelton, P. A., Dart, C., Conley, E. C., & Stanfield, P. R. (1997). Single subunit mutations of the murine K+ channel IRK1. JOURNAL OF PHYSIOLOGY-LONDON, 499P, P125-P126. Retrieved from http://gateway.webofknowledge.com/

    1996

    The use of the rat LAP LCR and promoter for the high-level constitutive expression of K+ channel cDNAs in a rat liver cell line (Journal article)

    Shelton, P. A., & Dart, C. (1996). The use of the rat LAP LCR and promoter for the high-level constitutive expression of K+ channel cDNAs in a rat liver cell line. FEBS LETTERS, 391(3), 282-286. doi:10.1016/0014-5793(96)00755-7

    DOI: 10.1016/0014-5793(96)00755-7

    The properties and distribution of inward rectifier potassium currents in pig coronary arterial smooth muscle (Journal article)

    Quayle, J. M., Dart, C., & Standen, N. B. (1996). The properties and distribution of inward rectifier potassium currents in pig coronary arterial smooth muscle. JOURNAL OF PHYSIOLOGY-LONDON, 494(3), 715-726. doi:10.1113/jphysiol.1996.sp021527

    DOI: 10.1113/jphysiol.1996.sp021527

    The role of potassium channels in t lymphocytes (Journal article)

    Badlev, S., Dart, C., Conley, E., & Brammar, W. (1996). The role of potassium channels in t lymphocytes. Biochemical Society Transactions, 24(4).

    1995

    ACTIVATION OF ATP-DEPENDENT K+ CHANNELS BY HYPOXIA IN SMOOTH-MUSCLE CELLS ISOLATED FROM THE PIG CORONARY-ARTERY (Journal article)

    DART, C., & STANDEN, N. B. (1995). ACTIVATION OF ATP-DEPENDENT K+ CHANNELS BY HYPOXIA IN SMOOTH-MUSCLE CELLS ISOLATED FROM THE PIG CORONARY-ARTERY. JOURNAL OF PHYSIOLOGY-LONDON, 483(1), 29-39. doi:10.1113/jphysiol.1995.sp020565

    DOI: 10.1113/jphysiol.1995.sp020565

    1994

    HYPOXIA INDUCES A POTASSIUM CURRENT IN SMOOTH-MUSCLE CELLS ISOLATED FROM THE PORCINE CORONARY-ARTERY (Journal article)

    DART, C., & STANDEN, N. B. (1994). HYPOXIA INDUCES A POTASSIUM CURRENT IN SMOOTH-MUSCLE CELLS ISOLATED FROM THE PORCINE CORONARY-ARTERY. JOURNAL OF PHYSIOLOGY-LONDON, 477P, P85-P86. Retrieved from http://gateway.webofknowledge.com/

    Adenosine activates potassium channels in porcine coronary arterial myocytes (Conference Paper)

    DART, C., & STANDEN, N. B. (1994). Adenosine activates potassium channels in porcine coronary arterial myocytes. In RESISTANCE ARTERIES (pp. 115-123). Retrieved from http://gateway.webofknowledge.com/

    1993

    ADENOSINE-ACTIVATED POTASSIUM CURRENT IN SMOOTH-MUSCLE CELLS ISOLATED FROM THE PIG CORONARY-ARTERY (Journal article)

    DART, C., & STANDEN, N. B. (1993). ADENOSINE-ACTIVATED POTASSIUM CURRENT IN SMOOTH-MUSCLE CELLS ISOLATED FROM THE PIG CORONARY-ARTERY. JOURNAL OF PHYSIOLOGY-LONDON, 471, 767-786. doi:10.1113/jphysiol.1993.sp019927

    DOI: 10.1113/jphysiol.1993.sp019927

    THE POTASSIUM CURRENT ACTIVATED BY ADENOSINE IN ISOLATED CORONARY ARTERIAL MYOCYTES OF THE PIG (Journal article)

    DART, C., & STANDEN, N. B. (1993). THE POTASSIUM CURRENT ACTIVATED BY ADENOSINE IN ISOLATED CORONARY ARTERIAL MYOCYTES OF THE PIG. JOURNAL OF PHYSIOLOGY-LONDON, 467, P270. Retrieved from http://gateway.webofknowledge.com/

    WHOLE CELL K+ CURRENT ACTIVATED BY LEMAKALIM IN ISOLATED MYOCYTES FROM RABBIT PULMONARY-ARTERY - ESTIMATE OF UNITARY CONDUCTANCE AND DENSITY BY NOISE-ANALYSIS (Journal article)

    LANGTON, P. D., CLAPP, L. H., DART, C., GURNEY, A. M., & STANDEN, N. B. (1993). WHOLE CELL K+ CURRENT ACTIVATED BY LEMAKALIM IN ISOLATED MYOCYTES FROM RABBIT PULMONARY-ARTERY - ESTIMATE OF UNITARY CONDUCTANCE AND DENSITY BY NOISE-ANALYSIS. JOURNAL OF PHYSIOLOGY-LONDON, 459, P254. Retrieved from http://gateway.webofknowledge.com/

    1992

    NA(+)-HCO3- SYMPORT IN THE SHEEP CARDIAC PURKINJE-FIBER (Journal article)

    DART, C., & VAUGHANJONES, R. D. (1992). NA(+)-HCO3- SYMPORT IN THE SHEEP CARDIAC PURKINJE-FIBER. JOURNAL OF PHYSIOLOGY-LONDON, 451, 365-385. doi:10.1113/jphysiol.1992.sp019169

    DOI: 10.1113/jphysiol.1992.sp019169

    EVIDENCE FOR A NA+-CL--H+-HCO3- EXCHANGE SYSTEM IN THE MAMMALIAN LENS (Journal article)

    DUNCAN, G., DART, C., CROGHAN, P. C., & GANDOLFI, S. A. (1992). EVIDENCE FOR A NA+-CL--H+-HCO3- EXCHANGE SYSTEM IN THE MAMMALIAN LENS. EXPERIMENTAL EYE RESEARCH, 54(6), 941-946. doi:10.1016/0014-4835(92)90158-O

    DOI: 10.1016/0014-4835(92)90158-O

    1990

    A HCO3-DEPENDENT MECHANISM REGULATES PHI FROM AN ACID LOAD IN ISOLATED SHEEP CARDIAC PURKINJE-FIBERS (Conference Paper)

    DART, C., & VAUGHANJONES, R. D. (1990). A HCO3-DEPENDENT MECHANISM REGULATES PHI FROM AN ACID LOAD IN ISOLATED SHEEP CARDIAC PURKINJE-FIBERS. In JOURNAL OF PHYSIOLOGY-LONDON Vol. 430 (pp. P74). Retrieved from http://gateway.webofknowledge.com/