This PhD project will focus on designing conceptually new metal-mediated selective C-H functionalisations of arenes without directing groups. This will be achieved by exploring the unique reactivity of transition metal complexes that coordinate arenes in a rare eta-4 mode. This coordination mode bends the aromatic ring and enables the arene to undergo a range of unconventional C-H (e. g. J. Am. Chem. Soc. 2022, 144, 11564) and C-C bond activations (e. g. J. Am. Chem. Soc. 2019, 141, 6048; Angew. Chem. Int. Ed. 2017, 56, 3266). These approaches have an excellent potential for the development of synthetically useful arene functionalisations. The project will involve synthetic and mechanistic studies, which will be supported by DFT computations in collaboration with our UoL colleagues.
Training
The successful applicant will receive training in modern analytical methods for characterisation of organic and organometallic compounds (NMR, MS, XRD, GC), the synthesis of organic/organometallic compounds using Schlenk and glovebox techniques, critical discussion of research results and reaction mechanisms, as well as research report writing and presenting. There will be an opportunity to participate in a student-led research seminar committee, inter-group problem solving sessions, and presentations. The knowledge and skills acquired will provide the candidate with a solid basis for candidate’s future academic or industrial career in organic chemistry and catalysis.