Research outputs
2025
Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches
Asiimwe, I. G., You, T., Carr, D. F., Pirmohamed, M., Davies, G., & Jorgensen, A. L. (2025). Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches. Clinical Pharmacology & Therapeutics. doi:10.1002/cpt.70171
Physiologically Based Pharmacokinetic Modelling of Serum 25-Hydroxyvitamin D Concentrations in Schoolchildren Receiving Weekly Oral Vitamin D<sub>3</sub> Supplementation
Muhamad, N., Walker, N., Middelkoop, K., Ganmaa, D., Martineau, A. R., & You, T. (2025). Physiologically Based Pharmacokinetic Modelling of Serum 25-Hydroxyvitamin D Concentrations in Schoolchildren Receiving Weekly Oral Vitamin D<sub>3</sub> Supplementation. NUTRIENTS, 17(19). doi:10.3390/nu17193028
Physiologically-Based Pharmacokinetic Modelling of Serum 25-Hydroxyvitamin D Concentrations in Schoolchildren Receiving Weekly Oral Vitamin D3 Supplementation
Inspecting Consistency Between US and European Vitamin D Guidelines Using Physiologically-Based Pharmacokinetics Modelling
2024
The pharmacokinetic differences between 10- and 15-μg daily vitamin D doses.
You, T., Muhamad, N., Jenner, J., & Huang, Z. (2024). The pharmacokinetic differences between 10- and 15-μg daily vitamin D doses.. British journal of clinical pharmacology. doi:10.1111/bcp.16146
2023
The Pharmacokinetics Difference between 10µg and 15µg Daily Vitamin D Doses
Modelling 25-hydroxyvitamin D responses to different recommended daily intakes of vitamin D
2022
Comparative assessment of viral dynamic models for SARS-CoV-2 for pharmacodynamic assessment in early treatment trials
Agyeman, A. A., You, T., Chan, P. L. S., Lonsdale, D. O., Hadjichrysanthou, C., Mahungu, T., . . . Standing, J. F. (2022). Comparative assessment of viral dynamic models for SARS-CoV-2 for pharmacodynamic assessment in early treatment trials. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 88(12), 5428-5433. doi:10.1111/bcp.15518
UK CTAP Briefing on Ivermectin.
Bonnet, M., Cave, A., Hofer, M., McConkey, G., Medcalf, N., Smith, S., . . . You, T. (2022). UK CTAP Briefing on Ivermectin. (DOI: 10.5281/zenodo.6011345.).
UK CTAP Briefing on Vitamin D. National Core Studies
Bonnet, M., Cave, A., Hofer, M., McConkey, G., Medcalf, N., Smith, S., . . . You, T. (2022). UK CTAP Briefing on Vitamin D. National Core Studies (DOI: 10.5281/zenodo.6011333.).
Choosing drugs for UK COVID-19 treatment trials COMMENT
Chinnery, P. F., Bonnet, M., Cave, A., Hofer, M. P., Lamb, A., McConkey, G. A., . . . You, T. (2022). Choosing drugs for UK COVID-19 treatment trials COMMENT. NATURE REVIEWS DRUG DISCOVERY, 21(2), 81-82. doi:10.1038/d41573-021-00203-7
2021
Personalise vitamin D<sub>3</sub> using physiologically based pharmacokinetic modelling
Huang, Z., & You, T. (2021). Personalise vitamin D<sub>3</sub> using physiologically based pharmacokinetic modelling. CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 10(7), 723-734. doi:10.1002/psp4.12640
2020
Personalise Dose Regimen of Vitamin D<sub>3</sub> Using Physiologically-Based Pharmacokinetic Modelling
2018
A mathematical model of antibody-dependent cellular cytotoxicity (ADCC)
Hoffman, F., Gavaghan, D., Osborne, J., Barrett, I. P., You, T., Ghadially, H., . . . Byrne, H. M. (2018). A mathematical model of antibody-dependent cellular cytotoxicity (ADCC). JOURNAL OF THEORETICAL BIOLOGY, 436, 39-50. doi:10.1016/j.jtbi.2017.09.031
2015
Investigating receptor enzyme activity using time-scale analysis
You, T., & Yue, H. (2015). Investigating receptor enzyme activity using time-scale analysis. IET SYSTEMS BIOLOGY, 9(6), 268-276. doi:10.1049/iet-syb.2015.0037
2014
Time scale analysis of receptor enzyme activity: Irreversible inhibition sometimes exhibits incubation-time independence
You, T., & Yue, H. (2014). Time scale analysis of receptor enzyme activity: Irreversible inhibition sometimes exhibits incubation-time independence. In 2014 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) (pp. 38-43). IEEE. doi:10.1109/bibm.2014.6999257
Mechanisms Underlying the Exquisite Sensitivity of Candida albicans to Combinatorial Cationic and Oxidative Stress That Enhances the Potent Fungicidal Activity of Phagocytes
Kaloriti, D., Jacobsen, M., Yin, Z., Patterson, M., Tillmann, A., Smith, D. A., . . . Brown, A. J. P. (2014). Mechanisms Underlying the Exquisite Sensitivity of Candida albicans to Combinatorial Cationic and Oxidative Stress That Enhances the Potent Fungicidal Activity of Phagocytes. MBIO, 5(4). doi:10.1128/mBio.01334-14
2013
Eukaryotic translation initiation factor interactions
You, T., Coghill, G., & Brown, A. (2013). Eukaryotic translation initiation factor interactions. In Encyclopedia of Systems Biology. Springer.
Translational control of GCN4
You, T., Coghill, G., & Brown, A. (2013). Translational control of GCN4. In Encyclopedia of Systems Biology. Springer.
2012
Combinatorial stresses kill pathogenic <i>Candida</i> species
Kaloriti, D., Tillmann, A., Cook, E., Jacobsen, M., You, T., Lenardon, M., . . . Brown, A. J. P. (2012). Combinatorial stresses kill pathogenic <i>Candida</i> species. MEDICAL MYCOLOGY, 50(7), 699-709. doi:10.3109/13693786.2012.672770
A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi.
You, T., Ingram, P., Jacobsen, M. D., Cook, E., McDonagh, A., Thorne, T., . . . Brown, A. J. P. (2012). A systems biology analysis of long and short-term memories of osmotic stress adaptation in fungi.. BMC research notes, 5, 258. doi:10.1186/1756-0500-5-258
2011
Analysing <i>GCN4</i> translational control in yeast by stochastic chemical kinetics modelling and simulation
You, T., Stansfield, I., Romano, M. C., Brown, A. J. P., & Coghill, G. M. (2011). Analysing <i>GCN4</i> translational control in yeast by stochastic chemical kinetics modelling and simulation. BMC SYSTEMS BIOLOGY, 5. doi:10.1186/1752-0509-5-131
2010
A quantitative model for mRNA translation in <i>Saccharomyces cerevisiae</i>
You, T., Coghill, G. M., & Brown, A. J. P. (2010). A quantitative model for mRNA translation in <i>Saccharomyces cerevisiae</i>. YEAST, 27(10), 785-800. doi:10.1002/yea.1770
2009
Modelling and Simulation of Amino Acid Starvation Responses in Yeast Saccharomyces cerevisiae
You, T. (2009, May 23). Modelling and Simulation of Amino Acid Starvation Responses in Yeast Saccharomyces cerevisiae.
2007
A Quantitative Model for the Translational Control of Gcn4 in Yeast
You, T., Coghill, G., & Brown, A. (2007). A Quantitative Model for the Translational Control of Gcn4 in Yeast. In Proceedings of the FOSBE 2007. University of Stuttgart: Fraunhofer IRB Verlag.
2006
Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways - Mechanism of tumorigenesis
Bi, X., Lin, Q., Foo, T. W., Joshi, S., You, T., Shen, H. -M., . . . Hew, C. -L. (2006). Proteomic analysis of colorectal cancer reveals alterations in metabolic pathways - Mechanism of tumorigenesis. MOLECULAR & CELLULAR PROTEOMICS, 5(6), 1119-1130. doi:10.1074/mcp.M500432-MCP200
SPLASH: Systematic proteomics laboratory analysis and storage hub
Lo, S. L., You, T., Lin, Q., Joshi, S. B., Chung, M. C. M., & Hew, C. L. (2006). SPLASH: Systematic proteomics laboratory analysis and storage hub. PROTEOMICS, 6(6), 1758-1769. doi:10.1002/pmic.200500378