Research
Detect disease early
• Lung Cancer Screening
Identify and validate blood borne multi-omics biomarkers to predict people at high risk of developing lung cancer or patients with undiagnosed disease.
Collaborators: Prof John Field, Dr Michael Davies and Prof Ruwanthi Kolamunnage-Dona
Deliver the right drug to the right patients at the right dose
• Pharmacokinetics of vitamin D in healthy adults and children
We developed the world's first accurate PBPK model for serum pharmacokinetics profile of vitamin D3 and its active metabolite in healthy adults for an extremely wide range of doses of vitamin D3.
Here is a summary and a blog post of the project.
You may use the simulator to simulate vitamin D in a healthy adult based on this model
Model and data on GitHub
We refined the model to predict pharmacokinetics in adults considering body weight. We have further developed an accurate model that can predict changes in serum 25-hydroxyvitamin D in healthy children for up to 3 years. This is the longest time course we know to-date.
Collaborator: Prof Adrian Martineau (QMUL), Prof Keren Middelkoop (Cape Town) and Dr Davaasambuu Ganmaa (Harvard)
• Vitamin D in pancreatic cancer
Modelling the pharmacological effects of vitamin D with a goal of developing an adjuvant therapy to improve patient outcomes
Collaborators: Prof Bill Greenhalf and Prof Dan Palmer
• Multimorbidity and Polypharmacy
Dose adjustment for polypharmacy treatments with model-based pharmacology analysis
Collaborators: Prof Sir Munir Pirmohamad and Dr Meng Xiaoli
• UNITE4TB
Support the early phase clinical trials of novel anti-tuberculosis drugs for drug-resistant tuberculosis on a worldwide platform
Collaborators: Prof Gerry Davies, Prof Andrea Jorgenson, Dr Dan Carr, Prof Elin Svensson (Uppsala), Dr Raman Sharma (GSK)
• Cancer Patient Stratification
AI has been successfully applied to generate accurate image-based consensus molecular subtyping for colorectal cancer. To improve patient outcomes, we are combining this with machine learning (genome-wide network-based modelling for patient stratification) and PK/PD modelling to predict tumour evolution in patients.
Collaborators: Prof Andy Jones and Prof Tim Maughan
• Nrf2 Modelling
Use of a systems toxicology approach to understand the role of liver metabolism and stress responses in drug toxicity
Previous collaborators: Prof Ian Copple, Dr Ciarán Fisher (GSK) and Dr Jon Lyon (GSK)
Find new cures to deadly diseases
• Antifungal Drug Discovery
A systems biology analysis of thioredoxin reductase inhibition to support discovery of a novel antifungal treatment
Collaborators: Prof Elaine Bignell (Exeter) and Prof Janet Quinn (Newcastle)
Discovery of novel antifungal drugs using in silico screening and AI
Collaborator: Prof Chen Haifeng (Shanghai Jiao Tong)
• Long-acting Injectables Development
I am part of the HALo project - the UK National Hub for Advanced Long-acting Therapeutics.
Collaborators: Prof Steve Rannard and Prof Andrew Owen
Research grants
Academia and Industry United Innovation and Treatment for Tuberculosis ( UNITE4TB)
EUROPEAN COMMISSION
June 2021 - May 2028
National Hub for Advanced Long-acting Therapeutics (HALo)
ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL
November 2024 - October 2030
Multiomic Lung Cancer Early Detection
CANCER RESEARCH UK (UK)
November 2024 - October 2025