Research outputs
Selected research outputs
- Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: A multi-center study (Journal article - 2018)
- A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity (Journal article - 2017)
- Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models (Journal article - 2024)
- A systems approach reveals species differences in hepatic stress response capacity (Journal article - 2023)
- Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication (Journal article - 2015)
- Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety (Journal article - 2026)
2026
Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety
Goldring, C. E., Russomanno, G., Pin, C., Trairatphisan, P., Beattie, K. A., Fisher, C. P., . . . Laplanche, L. (2026). Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety. NATURE REVIEWS DRUG DISCOVERY, 25(2), 138-153. doi:10.1038/s41573-025-01308-z
2025
Response to "Acetaminophen should be a critical reference hepatotoxin for evaluating human-relevant in vitro models"
Livoti, L. A., Sison-Young, R., Reddyhoff, D., Fisher, C. P., Gardner, I., Diaz-Nieto, R., . . . Copple, I. M. (2025). Response to "Acetaminophen should be a critical reference hepatotoxin for evaluating human-relevant in vitro models". TOXICOLOGICAL SCIENCES, 204(2), 253-254. doi:10.1093/toxsci/kfae164
2024
Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models
Livoti, L. A., Sison-Young, R., Reddyhoff, D., Fisher, C. P., Gardner, I., Diaz-Nieto, R., . . . Copple, I. M. (2024). Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models. Toxicological Sciences. doi:10.1093/toxsci/kfae133
2023
A systems approach reveals species differences in hepatic stress response capacity
Russomanno, G., Sison-Young, R., Livoti, L. A., Coghlan, H., Jenkins, R. E., Kunnen, S. J., . . . Copple, I. M. (2023). A systems approach reveals species differences in hepatic stress response capacity. TOXICOLOGICAL SCIENCES, 196(1), 112-125. doi:10.1093/toxsci/kfad085
Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System
Ali, S. -E., Meng, X., Kafu, L., Hammond, S., Zhao, Q., Ogese, M., . . . Naisbitt, D. J. (2023). Detection of Hepatic Drug Metabolite-Specific T-Cell Responses Using a Human Hepatocyte, Immune Cell Coculture System. CHEMICAL RESEARCH IN TOXICOLOGY, 36(3), 390-401. doi:10.1021/acs.chemrestox.2c00343
Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury
Ali, S. -E., Waddington, J. C., Lister, A., Sison-Young, R., Jones, R. P., Rehman, A. H., . . . Meng, X. (2023). Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury. TOXICOLOGICAL SCIENCES, 192(1), 106-116. doi:10.1093/toxsci/kfad015
2021
Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration
Chan, B. K. Y., Elmasry, M., Forootan, S. S., Russomanno, G., Bunday, T. M., Zhang, F., . . . Copple, I. M. (2021). Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration. HEPATOLOGY, 74(2), 973-986. doi:10.1002/hep.31859
2018
Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds
Oppelt, A., Kaschek, D., Huppelschoten, S., Sison-Young, R., Zhang, F., Buck-Wiese, M., . . . Klingmueuler, U. (2018). Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds. NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 4. doi:10.1038/s41540-018-0058-z
Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process
Dickens, D., Rädisch, S., Chiduza, G. N., Giannoudis, A., Cross, M. J., Malik, H., . . . Nies, A. T. (2018). Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process. Molecular Pharmaceutics, 15(8), 3557-3572. doi:10.1021/acs.molpharmaceut.8b00547
Expression and enzyme activity of cytochrome P450 enzymes CYP3A4 and CYP3A5 in human skin and tissue‐engineered skin equivalents
Smith, S., Colley, H., Sharma, P., Slowik, K., Sison-Young, R., Sneddon, A., . . . Murdoch, C. (2018). Expression and enzyme activity of cytochrome P450 enzymes CYP3A4 and CYP3A5 in human skin and tissue‐engineered skin equivalents. Experimental Dermatology, 27(5), 473-475. doi:10.1111/exd.13483
Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study
Bell, C. C., Dankers, A. C. A., Lauschke, V. M., Sison-Young, R., Jenkins, R., Rowe, C., . . . Ingelman-Sundberg, M. (2018). Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study. TOXICOLOGICAL SCIENCES, 162(2), 655-666. doi:10.1093/toxsci/kfx289
Innovative Organotypic In Vitro Models for Safety Assessment: Aligning with regulatory requirements and understanding models of the heart, skin and liver as paradigms
Park, B. K., & Goldring, C. (2018). Innovative Organotypic In Vitro Models for Safety Assessment: Aligning with regulatory requirements and understanding models of the heart, skin and liver as paradigms. Archives of Toxicology, 92(2), 557-569. doi:10.1007/s00204-018-2152-9
Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins
Rowe, C., Shaeri, M., Large, E., Cornforth, T., Robinson, A., Kostrzewski, T., . . . Hughes, D. (2018). Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins. TOXICOLOGY IN VITRO, 46, 29-38. doi:10.1016/j.tiv.2017.09.012
Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: A multi-center study
Bell, C., Dankers, A., Lauschke, V., Sison-Young, R., Jenkins, R., Rowe, C., . . . Ingelman-Sundberg, M. (2018). Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: A multi-center study. Toxicological Sciences. doi:10.1093/toxsci/kfx289
2017
Donor-Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells (vol 6, 1751, 2017)
Heslop, J. A., Kia, R., Pridgeon, C. S., Sison-Young, R. L., Liloglou, T., Elmasry, M., . . . Park, B. K. (2017). Donor-Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells (vol 6, 1751, 2017). STEM CELLS TRANSLATIONAL MEDICINE, 6(8). Retrieved from https://www.webofscience.com/
Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development
Goldring, C., Weaver, R., Kramer, B., Klingmueller, U., Oppelt, A., Van der Water, B., . . . Park, B. K. (2017). Drug-Induced Liver Injury: Mechanism-Informed Prediction in Drug Development. In COMPREHENSIVE MEDICINAL CHEMISTRY III, VOL 4: EXPERIMENTAL ADME AND TOXICOLOGY (pp. 217-238). doi:10.1016/B978-0-12-409547-2.12384-4
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
Sison-Young, R. L., Lauschke, V. M., Johann, E., Alexandre, E., Antherieu, S., Aerts, H., . . . Park, B. K. (2017). A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. Archives of Toxicology, 91(3), 1385-1400. doi:10.1007/s00204-016-1745-4
Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile
Heslop, J. A., Rowe, C., Walsh, J., Sison-Young, R., Jenkins, R., Kamalian, L., . . . Kevin Park, B. (2017). Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile. Archives of Toxicology, 91(1), 439-452. doi:10.1007/s00204-016-1694-y
2016
Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation
Lauschke, V. M., Vorrink, S. U., Moro, S. M. L., Rezayee, F., Nordling, A., Hendriks, D. F. G., . . . Ingelman-Sundberg, M. (2016). Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation. HEPATOLOGY, 64(5), 1743-1756. doi:10.1002/hep.28780
Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats
Richert, L., Baze, A., Parmentier, C., Gerets, H. H. J., Sison-Young, R., Dorau, M., . . . Williams, D. P. (2016). Cytotoxicity evaluation using cryopreserved primary human hepatocytes in various culture formats. TOXICOLOGY LETTERS, 258, 207-215. doi:10.1016/j.toxlet.2016.06.1127
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
Bell, C. C., Hendriks, D. F. G., Moro, S. M. L., Ellis, E., Walsh, J., Renblom, A., . . . Ingelman-Sundberg, M. (2016). Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Scientific Reports, 6. doi:10.1038/srep25187
2015
Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication
Sison-Young, R. L. C., Mitsa, D., Jenkins, R. E., Mottram, D., Alexandre, E., Richert, L., . . . Park, B. K. (2015). Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication. TOXICOLOGICAL SCIENCES, 147(2), 412-424. doi:10.1093/toxsci/kfv136
Mechanism-Based Markers of Drug-Induced Liver Injury to Improve the Physiological Relevance and Predictivity of <i>In Vitro</i> Models
Goldring, C., Norris, A., Kitteringham, N., Aleo, M. D., Antoine, D. J., Heslop, J., . . . Park, B. K. (2015). Mechanism-Based Markers of Drug-Induced Liver Injury to Improve the Physiological Relevance and Predictivity of <i>In Vitro</i> Models. Applied In Vitro Toxicology, 1(3), 175-186. doi:10.1089/aivt.2015.0001
Glutathione metabolism in the HaCaT cell line as a model for the detoxification of the model sensitisers 2,4-dinitrohalobenzenes in human skin
Jacquoilleot, S., Sheffield, D., Olayanju, A., Sison-Young, R., Kitteringham, N. R., Naisbitt, D. J., & Aleksic, M. (2015). Glutathione metabolism in the HaCaT cell line as a model for the detoxification of the model sensitisers 2,4-dinitrohalobenzenes in human skin. TOXICOLOGY LETTERS, 237(1), 11-20. doi:10.1016/j.toxlet.2015.05.016
MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity
Kia, R., Kelly, L., Sison-Young, R. L. C., Zhang, F., Pridgeon, C. S., Heslop, J. A., . . . Park, B. K. (2015). MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity. Toxicological sciences : an official journal of the Society of Toxicology, 144(01), 173-185. doi:10.1093/toxsci/kfu269
Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes
Baxter, M., Withey, S., Harrison, S., Segeritz, C. -P., Zhang, F., Atkinson-Dell, R., . . . Hanley, N. A. (2015). Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes. Journal of Hepatology, 62(3), 581-589. doi:10.1016/j.jhep.2014.10.016
Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.
Olayanju, A., Copple, I., Bryan, H. K., Edge, G. T., Sison-Young, R., Wong, M. W., . . . Park, K. (2015). Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.. Free Radical Biology & Medicine, 78, 202-212.
2013
Safety pharmacology - Current and emerging concepts
Hamdam, J., Sethu, S., Smith, T., Alfirevic, A., Alhaidari, M., Atkinson, J., . . . Goldring, C. (2013). Safety pharmacology - Current and emerging concepts. TOXICOLOGY AND APPLIED PHARMACOLOGY, 273(2), 229-241. doi:10.1016/j.taap.2013.04.039
2012
Human pluripotent stem cells for modeling toxicity.
Sison-Young, R. L. C., Kia, R., Heslop, J., Kelly, L., Rowe, C., Cross, M. J., . . . Goldring, C. E. P. (2012). Human pluripotent stem cells for modeling toxicity.. Advances in pharmacology (San Diego, Calif.), 63, 207-256. doi:10.1016/b978-0-12-398339-8.00006-9
2010
Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver
Kitteringham, N. R., Abdullah, A., Walsh, J., Randle, L., Jenkins, R. E., Sison, R., . . . Park, B. K. (2010). Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. JOURNAL OF PROTEOMICS, 73(8), 1612-1631. doi:10.1016/j.jprot.2010.03.018