Research outputs
2026
Cell-matrix mechanosensing and cellular metabolic demand are linked through SKT and mTORC2
Talin-tensin3 interactions regulate fibrillar adhesion formation and tensin3 phase separation
Li, X., Konstantinou, R., Meena, V. K., Notash, S., Khalil, K., Whalley, T., . . . Ballestrem, C. (2025). Talin-tensin3 interactions regulate fibrillar adhesion formation and tensin3 phase separation. JOURNAL OF CELL BIOLOGY, 225(1). doi:10.1083/jcb.202503155
2024
Colorectal carcinoma progression is not influenced by the pseudokinase PEAK1
Zuidema, A., Atherton, P., van der Poel, S., Kreft, M., Song, J. -Y., Bierbooms, M., . . . Sonnenberg, A. (2024). Colorectal carcinoma progression is not influenced by the pseudokinase PEAK1. SCIENTIFIC REPORTS, 14(1). doi:10.1038/s41598-024-78776-7
Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility
Wang, W., Atherton, P., Kreft, M., te Molder, L., van der Poel, S., Hoekman, L., . . . Sonnenberg, A. (2024). Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility. JOURNAL OF CELL SCIENCE, 137(9). doi:10.1242/jcs.262116
Caskin2 is a novel talin and Abi1-binding protein that promotes cell motility
2022
Tensin3 interaction with talin drives the formation of fibronectin-associated fibrillar adhesions
Atherton, P., Konstantinou, R., Neo, S. P., Wang, E., Balloi, E., Ptushkina, M., . . . Ballestrem, C. (2022). Tensin3 interaction with talin drives the formation of fibronectin-associated fibrillar adhesions. JOURNAL OF CELL BIOLOGY, 221(10). doi:10.1083/jcb.202107022
PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins
Zuidema, A., Atherton, P., Kreft, M., Hoekman, L., Bleijerveld, O. B., Nagaraj, N., . . . Sonnenberg, A. (2022). PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins. JOURNAL OF CELL BIOLOGY, 221(8). doi:10.1083/jcb.202108027
2021
Vinculin is required for neuronal mechanosensing but not for axon outgrowth
Wang, D. -Y., Melero, C., Albaraky, A., Atherton, P., Jansen, K. A., Dimitracopoulos, A., . . . Ballestrem, C. (2021). Vinculin is required for neuronal mechanosensing but not for axon outgrowth. EXPERIMENTAL CELL RESEARCH, 407(2). doi:10.1016/j.yexcr.2021.112805
Tensin3 interaction with talin drives formation of fibronectin-associated fibrillar adhesions
2020
Relief of talin autoinhibition triggers a force-independent association with vinculin
Atherton, P., Lausecker, F., Carisey, A., Gilmore, A., Critchley, D., Barsukov, I., & Ballestrem, C. (2020). Relief of talin autoinhibition triggers a force-independent association with vinculin. JOURNAL OF CELL BIOLOGY, 219(1). doi:10.1083/jcb.201903134
2019
Light-Induced Molecular Adsorption of Proteins Using the PRIMO System for Micro-Patterning to Study Cell Responses to Extracellular Matrix Proteins
Melero, C., Kolmogorova, A., Atherton, P., Derby, B., Reid, A., Jansen, K., & Ballestrem, C. (2019). Light-Induced Molecular Adsorption of Proteins Using the PRIMO System for Micro-Patterning to Study Cell Responses to Extracellular Matrix Proteins. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (152). doi:10.3791/60092
Force-independent interactions of talin and vinculin govern integrin-mediated mechanotransduction
GAS2-like 1 coordinates cell division through its association with end-binding proteins
Nazgiewicz, A., Atherton, P., & Ballestrem, C. (2019). GAS2-like 1 coordinates cell division through its association with end-binding proteins. SCIENTIFIC REPORTS, 9. doi:10.1038/s41598-019-42242-6
2018
Co-ordination of mechanotransduction by talin and vinculin
Atherton, P., Lausecker, F., Barsukov, I., Critchley, D., & Ballestrem, C. (2018). Co-ordination of mechanotransduction by talin and vinculin. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A21). Retrieved from https://www.webofscience.com/
2017
Mechanotransduction at the cell-matrix interface
Jansen, K. A., Atherton, P., & Ballestrem, C. (2017). Mechanotransduction at the cell-matrix interface. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 71, 75-83. doi:10.1016/j.semcdb.2017.07.027
Low-intensity pulsed ultrasound promotes cell motility through vinculin-controlled Rac1 GTPase activity
Atherton, P., Lausecker, F., Harrison, A., & Ballestrem, C. (2017). Low-intensity pulsed ultrasound promotes cell motility through vinculin-controlled Rac1 GTPase activity. JOURNAL OF CELL SCIENCE, 130(14), 2277-2291. doi:10.1242/jcs.192781
Distinct focal adhesion protein modules control different aspects of mechanotransduction
Stutchbury, B., Atherton, P., Tsang, R., Wang, D. -Y., & Ballestrem, C. (2017). Distinct focal adhesion protein modules control different aspects of mechanotransduction. JOURNAL OF CELL SCIENCE, 130(9), 1612-1624. doi:10.1242/jcs.195362
Talin gets SHANKed in the fight for integrin activation
Atherton, P., & Ballestrem, C. (2017). Talin gets SHANKed in the fight for integrin activation. NATURE CELL BIOLOGY, 19(4), 265-267. doi:10.1038/ncb3501
2016
Mechanosensitive components of integrin adhesions: Role of vinculin
Atherton, P., Stutchbury, B., Jethwa, D., & Ballestrem, C. (2016). Mechanosensitive components of integrin adhesions: Role of vinculin. EXPERIMENTAL CELL RESEARCH, 343(1), 21-27. doi:10.1016/j.yexcr.2015.11.017
2015
Vinculin controls talin engagement with the actomyosin machinery.
Atherton, P., Stutchbury, B., Wang, D. -Y., Jethwa, D., Tsang, R., Meiler-Rodriguez, E., . . . Ballestrem, C. (2015). Vinculin controls talin engagement with the actomyosin machinery.. Nature communications, 6. doi:10.1038/ncomms10038