Research outputs
Selected research outputs
- Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression (Journal article - 2022)
- The context-specific roles of urea cycle enzymes in tumorigenesis (Journal article - 2021)
- Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses (Journal article - 2021)
- Metabolic Drivers in Hereditary Cancer Syndromes (Book - 2020)
- Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells (Journal article - 2018)
- Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects (Journal article - 2017)
- Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition (Journal article - 2016)
- The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase (Journal article - 2013)
2025
A systematic review of omics discovery studies to identify pertinent metabolic pathways for locally advanced rectal cancer in response to neoadjuvant chemoradiotherapy.
Kler, A., Fok, M., Grundy, G. J., Sciacovelli, M., Dunn, W. B., & Vimalachandran, D. (2025). A systematic review of omics discovery studies to identify pertinent metabolic pathways for locally advanced rectal cancer in response to neoadjuvant chemoradiotherapy. . Metabolomics : Official journal of the Metabolomic Society, 21(5), 124. doi:10.1007/s11306-025-02319-y
2024
KRAS G12 mutant alleles differentially control glutamine metabolism via FOXO1
Corrigendum to "Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells" [Metabol. Eng. 45 (2018) 149-157].
Gonçalves, E., Sciacovelli, M., Costa, A. S. H., Tran, M. G. B., Johnson, T. I., Machado, D., . . . Saez-Rodriguez, J. (2024). Corrigendum to "Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells" [Metabol. Eng. 45 (2018) 149-157].. Metabolic engineering, 82, 297-298. doi:10.1016/j.ymben.2024.01.002
2023
FOXA2 controls the anti-oxidant response in FH-deficient cells
Rogerson, C., Sciacovelli, M., Maddalena, L. A., Pouikli, A., Segarra-Mondejar, M., Valcarcel-Jimenez, L., . . . Frezza, C. (2023). FOXA2 controls the anti-oxidant response in FH-deficient cells. CELL REPORTS, 42(7). doi:10.1016/j.celrep.2023.112751
2022
Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression
Sciacovelli, M., Dugourd, A., Jimenez, L. V., Yang, M., Nikitopoulou, E., Costa, A. S. H., . . . Frezza, C. (2022). Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression. NATURE COMMUNICATIONS, 13(1). doi:10.1038/s41467-022-35036-4
2021
The context-specific roles of urea cycle enzymes in tumorigenesis
Hajaj, E., Sciacovelli, M., Frezza, C., & Erez, A. (2021). The context-specific roles of urea cycle enzymes in tumorigenesis. MOLECULAR CELL, 81(18), 3749-3759. doi:10.1016/j.molcel.2021.08.005
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis
Bodineau, C., Tome, M., Courtois, S., Costa, A. S. H., Sciacovelli, M., Rousseau, B., . . . Duran, R. V. (2021). Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-25079-4
Low P66shc with High SerpinB3 Levels Favors Necroptosis and Better Survival in Hepatocellular Carcinoma
Fasolato, S., Ruvoletto, M., Nardo, G., Rasola, A., Sciacovelli, M., Zanus, G., . . . Pontisso, P. (2021). Low P66shc with High SerpinB3 Levels Favors Necroptosis and Better Survival in Hepatocellular Carcinoma. BIOLOGY-BASEL, 10(5). doi:10.3390/biology10050363
Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells
Sant'Anna-Silva, A. C. B., Perez-Valencia, J. A., Sciacovelli, M., Lalou, C., Sarlak, S., Tronci, L., . . . Klocker, H. (2021). Succinate Anaplerosis Has an Onco-Driving Potential in Prostate Cancer Cells. CANCERS, 13(7). doi:10.3390/cancers13071727
Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses
Dugourd, A., Kuppe, C., Sciacovelli, M., Gjerga, E., Gabor, A., Emdal, K. B., . . . Saez-Rodriguez, J. (2021). Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses. MOLECULAR SYSTEMS BIOLOGY, 17(1). doi:10.15252/msb.20209730
2020
Metabolic Drivers in Hereditary Cancer Syndromes
Sciacovelli, M., Schmidt, C., Maher, E. R., & Frezza, C. (2020). Metabolic Drivers in Hereditary Cancer Syndromes (Vol. 4). doi:10.1146/annurev-cancerbio-030419-033612
Fumarate hydratase in cancer: A multifaceted tumour suppressor
Schmidt, C., Sciacovelli, M., & Frezza, C. (2020). Fumarate hydratase in cancer: A multifaceted tumour suppressor. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 98, 15-25. doi:10.1016/j.semcdb.2019.05.002
2018
Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells
Goncalves, E., Sciacovelli, M., Costa, A. S. H., Tran, M. G. B., Johnson, T. I., Machado, D., . . . Saez-Rodriguez, J. (2018). Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells. METABOLIC ENGINEERING, 45, 149-157. doi:10.1016/j.ymben.2017.11.011
2017
Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
Tyrakis, P. A., Yurkovich, M. E., Sciacovelli, M., Papachristou, E. K., Bridges, H. R., Gaude, E., . . . Frezza, C. (2017). Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects. CELL REPORTS, 21(4), 1036-1047. doi:10.1016/j.celrep.2017.09.092
Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer
Sciacovelli, M., & Frezza, C. (2017). Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer. FEBS JOURNAL, 284(19), 3132-3144. doi:10.1111/febs.14090
Mutations in mitochondrial DNA causing tubulointerstitial kidney disease
Connor, T. M., Hoer, S., Mallett, A., Gale, D. P., Gomez-Duran, A., Posse, V., . . . Maxwell, P. H. (2017). Mutations in mitochondrial DNA causing tubulointerstitial kidney disease. PLOS GENETICS, 13(3). doi:10.1371/journal.pgen.1006620
Fumarate drives EMT in renal cancer
Sciacovelli, M., & Frezza, C. (2017). Fumarate drives EMT in renal cancer. CELL DEATH AND DIFFERENTIATION, 24(1), 1-2. doi:10.1038/cdd.2016.137
2016
Oncometabolites: Unconventional triggers of oncogenic signalling cascades
Sciacovelli, M., & Frezza, C. (2016). Oncometabolites: Unconventional triggers of oncogenic signalling cascades. FREE RADICAL BIOLOGY AND MEDICINE, 100, 175-181. doi:10.1016/j.freeradbiomed.2016.04.025
Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
Sciacovelli, M., Goncalves, E., Johnson, T. I., Zecchini, V. R., da Costa, A. S. H., Gaude, E., . . . Frezza, C. (2016). Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition. NATURE, 537(7621), 544-+. doi:10.1038/nature19353
2015
Fumarate induces redox-dependent senescence by modifying glutathione metabolism
Zheng, L., Cardaci, S., Jerby, L., MacKenzie, E. D., Sciacovelli, M., Johnson, T. I., . . . Gottlieb, E. (2015). Fumarate induces redox-dependent senescence by modifying glutathione metabolism. NATURE COMMUNICATIONS, 6. doi:10.1038/ncomms7001
2014
Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells
Guzzo, G., Sciacovelli, M., Bernardi, P., & Rasola, A. (2014). Inhibition of succinate dehydrogenase by the mitochondrial chaperone TRAP1 has anti-oxidant and anti-apoptotic effects on tumor cells. ONCOTARGET, 5(23), 11897-11908. doi:10.18632/oncotarget.2472
Germline <i>FH</i> Mutations Presenting With Pheochromocytoma
Clark, G. R., Sciacovelli, M., Gaude, E., Walsh, D. M., Kirby, G., Simpson, M. A., . . . Maher, E. R. (2014). Germline <i>FH</i> Mutations Presenting With Pheochromocytoma. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 99(10), E2046-E2050. doi:10.1210/jc.2014-1659
SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I
Ciscato, F., Sciacovelli, M., Villano, G., Turato, C., Bernardi, P., Rasola, A., & Pontisso, P. (2014). SERPINB3 protects from oxidative damage by chemotherapeutics through inhibition of mitochondrial respiratory complex I. ONCOTARGET, 5(9), 2418-2427. doi:10.18632/oncotarget.1411
The Metabolic Alterations of Cancer Cells
Sciacovelli, M., Gaude, E., Hilvo, M., & Frezza, C. (2014). The Metabolic Alterations of Cancer Cells. In CONCEPTUAL BACKGROUND AND BIOENERGETIC/MITOCHONDRIAL ASPECTS OF ONCOMETABOLISM (Vol. 542, pp. 1-23). doi:10.1016/B978-0-12-416618-9.00001-7
2013
The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase
Sciacovelli, M., Guzzo, G., Morello, V., Frezza, C., Zheng, L., Nannini, N., . . . Rasola, A. (2013). The Mitochondrial Chaperone TRAP1 Promotes Neoplastic Growth by Inhibiting Succinate Dehydrogenase. CELL METABOLISM, 17(6), 988-999. doi:10.1016/j.cmet.2013.04.019
2012
Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death.
Chiara, F., Gambalunga, A., Sciacovelli, M., Nicolli, A., Ronconi, L., Fregona, D., . . . Trevisan, A. (2012). Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death.. Cell death & disease, 3, e444. doi:10.1038/cddis.2012.184
2011
Antamanide, a Derivative of <i>Amanita phalloides</i>, Is a Novel Inhibitor of the Mitochondrial Permeability Transition Pore
Azzolin, L., Antolini, N., Calderan, A., Ruzza, P., Sciacovelli, M., Marin, O., . . . Rasola, A. (2011). Antamanide, a Derivative of <i>Amanita phalloides</i>, Is a Novel Inhibitor of the Mitochondrial Permeability Transition Pore. PLOS ONE, 6(1). doi:10.1371/journal.pone.0016280
2010
Signal transduction to the permeability transition pore
Rasola, A., Sciacovelli, M., Pantic, B., & Bernardi, P. (2010). Signal transduction to the permeability transition pore. FEBS LETTERS, 584(10), 1989-1996. doi:10.1016/j.febslet.2010.02.022
Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition
Rasola, A., Sciacovelli, M., Chiara, F., Pantic, B., Brusilow, W. S., & Bernardi, P. (2010). Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(2), 726-731. doi:10.1073/pnas.0912742107