About
I joined the University of Liverpool in 2000 to begin a research career investigating the pathophysiology of chronic lymphocytic leukaemia. My group was the first to suggest a role for protein kinase CbetaII in the pathogenesis of CLL, and first to identify aberrant expression of Lck as a potential therapeutic target. My group pioneered understanding of B cell receptor signal pathway rewiring in CLL, and has developed novel techniques, such as Proximity Ligant AssaY for Rna (PLAYR), for mulitplex analysis of RNA expression in single cells using mass cytometry. Prior to Liverpool, I worked at the University of Ulm characterising the expression and function of protease activated receptors on monocytic cells, the University of Würzburg where I was first to demonstrate c-Raf-BRaf heterodimerisation, and I was a fellow of the Max-Planck-Society where my findings characterising the pro-inflammatory response of vascular endothelial cells to activated platelets have become citation classics. I gained my PhD from the University of Liverpool in 1994.