Research outputs
2025
Proteomics- and BRET- screens identify SPRY2 as a Ras effector that impacts its membrane organization.
Pavic, K., Hood, F. E., Duval, C. J., Manoharan, G. B., Laurini, C., Siddiqui, F. A., . . . Abankwa, D. K. (2025). Proteomics- and BRET- screens identify SPRY2 as a Ras effector that impacts its membrane organization.. iScience, 28(12), 113974. doi:10.1016/j.isci.2025.113974
2023
Ras protein abundance correlates with Ras isoform mutation patterns in cancer
Hood, F. E., Sahraoui, Y. M., Jenkins, R. E., & Prior, I. A. (2023). Ras protein abundance correlates with Ras isoform mutation patterns in cancer. ONCOGENE, 42(15), 1224-1232. doi:10.1038/s41388-023-02638-1
2021
Absolute Quantitation of GTPase Protein Abundance
Hood, F. E., Sahraoui, Y. M., Jenkins, R. E., & Prior, I. (2021). Absolute Quantitation of GTPase Protein Abundance. RAS ACTIVITY AND SIGNALING, 2262, 65-90. doi:10.1007/978-1-0716-1190-6_4
2020
The Frequency of Ras Mutations in Cancer
Prior, I. A., Hood, F. E., & Hartley, J. L. (2020). The Frequency of Ras Mutations in Cancer. Cancer Research, 80(14), 2969-2974. doi:10.1158/0008-5472.CAN-19-3682
2019
Isoform-specific Ras signaling is growth factor dependent
Hood, F. E., Klinger, B., Newlaczyl, A. U., Sieber, A., Dorel, M., Oliver, S. P., . . . Prior, I. A. (2019). Isoform-specific Ras signaling is growth factor dependent. Molecular biology of the cell, 30(9), 1108-1117. doi:10.1091/mbc.e18-10-0676
2018
New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome
Wilson, L. J., Linley, A., Hammond, D. E., Hood, F. E., Coulson, J. M., MacEwan, D. J., . . . Prior, I. A. (2018). New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome. CANCER RESEARCH, 78(1), 15-29. doi:10.1158/0008-5472.CAN-17-2291
2017
Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS
Narvaez, A. J., Ber, S., Crooks, A., Emery, A., Hardwick, B., Almeida, E. G., . . . Venkitaraman, A. R. (2017). Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS. CELL CHEMICAL BIOLOGY, 24(8), 1017-1028.E7. doi:10.1016/j.chembiol.2017.07.009
2015
The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle
Nixon, F. M., Gutierrez-Caballero, C., Hood, F. E., Booth, D. G., Prior, I. A., & Royle, S. J. (2015). The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle. ELIFE, 4. doi:10.7554/eLife.07635
Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression
O'Regan, L., Sampson, J., Richards, M. W., Knebel, A., Roth, D., Hood, F. E., . . . Fry, A. M. (2015). Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression. JOURNAL OF CELL BIOLOGY, 209(3), 349-358. doi:10.1083/jcb.201409151
2014
Decoding RAS isoform and codon-specific signalling
Newlaczyl, A. U., Hood, F. E., Coulson, J. M., & Prior, I. A. (2014). Decoding RAS isoform and codon-specific signalling. BIOCHEMICAL SOCIETY TRANSACTIONS, 42, 742-746. doi:10.1042/BST20140057
2013
Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding.
Hood, F. E., Williams, S. J., Burgess, S. G., Richards, M. W., Roth, D., Straube, A., . . . Royle, S. J. (2013). Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding.. The Journal of cell biology, 202(3), 463-478. doi:10.1083/jcb.201211127
2011
Aurora A kinase activity is required for localization of TACC3/ch-TOG/clathrin inter-microtubule bridges
Cheeseman, L. P., Booth, D. G., Hood, F. E., Prior, I. A., & Royle, S. J. (2011). Aurora A kinase activity is required for localization of TACC3/ch-TOG/clathrin inter-microtubule bridges. Communicative & Integrative Biology, 4(4), 409-412. doi:10.4161/cib.15250
Aurora A kinase activity is required for localization of TACC3/ch-TOG/clathrin inter-microtubule bridges.
Cheeseman, L. P., Booth, D. G., Hood, F. E., Prior, I. A., & Royle, S. J. (2011). Aurora A kinase activity is required for localization of TACC3/ch-TOG/clathrin inter-microtubule bridges.. Communicative & integrative biology, 4(4), 409-412. doi:10.4161/cib.15250
A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging
Booth, D. G., Hood, F. E., Prior, I. A., & Royle, S. J. (2011). A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging. EMBO JOURNAL, 30(5), 906-919. doi:10.1038/emboj.2011.15
Pulling it together: The mitotic function of TACC3.
Hood, F. E., & Royle, S. J. (2011). Pulling it together: The mitotic function of TACC3.. Bioarchitecture, 1(3), 105-109. doi:10.4161/bioa.1.3.16518
Pulling it together: the role of TACC3 in mitosis
Hood, F. E., & Royle, S. J. (2011). Pulling it together: the role of TACC3 in mitosis. BioArchitecture, 1(3), 105-109.
2010
The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells.
Hitakomate, E., Hood, F. E., Sanderson, H. S., & Clarke, P. R. (2010). The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells.. BMC cell biology, 11, 43. doi:10.1186/1471-2121-11-43
2009
Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.
Hood, F. E., & Royle, S. J. (2009). Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.. Journal of cell science, 122(Pt 13), 2185-2190. doi:10.1242/jcs.046177
2007
RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation.
Hood, F. E., & Clarke, P. R. (2007). RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation.. Journal of cell science, 120(Pt 19), 3436-3445. doi:10.1242/jcs.009092
Differential Interactions of Human RCC1 Isoforms and their Regulation by Phoshorylation
Hood, F. E. (2007). Differential Interactions of Human RCC1 Isoforms and their Regulation by Phoshorylation. (PhD Thesis, The University of Dundee).
2004
Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis.
Hutchins, J. R. A., Moore, W. J., Hood, F. E., Wilson, J. S. J., Andrews, P. D., Swedlow, J. R., & Clarke, P. R. (2004). Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis.. Current biology : CB, 14(12), 1099-1104. doi:10.1016/j.cub.2004.05.021