Publications
2025
Dietary substances and their glucuronides: structures, occurrence and biological activity.
Stachulski, A. V., Yates, E. A., Teriosina, A., Hoyles, L., & McArthur, S. (2025). Dietary substances and their glucuronides: structures, occurrence and biological activity.. Natural product reports. doi:10.1039/d5np00002e
Detection of β-D-glucuronidase activity in environmental samples using 4-fluorophenyl β-D-glucuronide and <sup>19</sup>F NMR.
Teriosina, A., Barsukov, I. L., Cartmell, A., Powell, A. K., Stachulski, A. V., & Yates, E. A. (2025). Detection of β-D-glucuronidase activity in environmental samples using 4-fluorophenyl β-D-glucuronide and <sup>19</sup>F NMR.. Analytical methods : advancing methods and applications, 17(9), 2015-2020. doi:10.1039/d4ay01723d
Dynamic kinetic resolution-mediated synthesis of C-3 hydroxylated arginine derivatives.
Zheng, Y., Chen, Z., Clarkson, G. J., Marshall, S. A., Xiao, J., Schofield, C. J., . . . Stachulski, A. V. (2025). Dynamic kinetic resolution-mediated synthesis of C-3 hydroxylated arginine derivatives.. Royal Society open science, 12(2), 241607. doi:10.1098/rsos.241607
Synthetic β-<scp>d</scp>-Glucuronides: Substrates for Exploring Glucuronide Degradation by Human Gut Bacteria
Gorecka, A., Schacht, H., Fraser, M. K., Teriosina, A., London, J. A., Barsukov, I. L., . . . Yates, E. A. (2024). Synthetic β-<scp>d</scp>-Glucuronides: Substrates for Exploring Glucuronide Degradation by Human Gut Bacteria. ACS Omega. doi:10.1021/acsomega.4c09036
2024
Cerebrovascular damage caused by the gut microbe/host co-metabolite <i>p</i>-cresol sulfate is prevented by blockade of the EGF receptor.
Shah, S. N., Knausenberger, T. B. -A., Pontifex, M. G., Connell, E., Le Gall, G., Hardy, T. A. J., . . . McArthur, S. (2024). Cerebrovascular damage caused by the gut microbe/host co-metabolite <i>p</i>-cresol sulfate is prevented by blockade of the EGF receptor.. Gut microbes, 16(1), 2431651. doi:10.1080/19490976.2024.2431651
Convenient syntheses of 2-acylamino-4-halothiazoles and acylated derivatives using a versatile Boc-intermediate.
Pate, S., Taujanskas, J., Wells, R., Robertson, C. M., O'Neill, P. M., & Stachulski, A. V. (2024). Convenient syntheses of 2-acylamino-4-halothiazoles and acylated derivatives using a versatile Boc-intermediate.. RSC advances, 14(38), 27894-27903. doi:10.1039/d4ra04959d
Transacylation and hydrolysis of the acyl glucuronides of ibuprofen and its α-methyl-substituted analogues investigated by <sup>1</sup>H NMR spectroscopy and computational chemistry: Implications for drug design.
Richards, S. E., Bradshaw, P. R., Johnson, C. H., Stachulski, A. V., Athersuch, T. J., Nicholson, J. K., . . . Wilson, I. D. (2024). Transacylation and hydrolysis of the acyl glucuronides of ibuprofen and its α-methyl-substituted analogues investigated by <sup>1</sup>H NMR spectroscopy and computational chemistry: Implications for drug design.. Journal of pharmaceutical and biomedical analysis, 246, 116238. doi:10.1016/j.jpba.2024.116238
2023
Convenient syntheses of <i>trans</i>-resveratrol 3-<i>O</i> and 4′-<i>O</i>-β-<scp>d</scp>-glucuronides and a study of their aqueous stability
Fraser, M. K., Gorecka, A., Yates, E. A., Iggo, J. A., Baj, K., & Stachulski, A. V. (2023). Convenient syntheses of <i>trans</i>-resveratrol 3-<i>O</i> and 4′-<i>O</i>-β-<scp>d</scp>-glucuronides and a study of their aqueous stability. Organic Chemistry Frontiers. doi:10.1039/d3qo01736b
Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity.
Stachulski, A. V., Rossignol, J. -F., Pate, S., Taujanskas, J., Iggo, J. A., Aerts, R., . . . O'Neill, P. M. (2023). Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity.. ACS bio & med chem Au, 3(4), 327-334. doi:10.1021/acsbiomedchemau.2c00083
A host-gut microbial amino acid co-metabolite, <i>p</i>-cresol glucuronide, promotes blood-brain barrier integrity <i>in vivo</i>
Stachulski, A. V., Knausenberger, T. B. -A., Shah, S. N., Hoyles, L., & McArthur, S. (2023). A host-gut microbial amino acid co-metabolite, <i>p</i>-cresol glucuronide, promotes blood-brain barrier integrity <i>in vivo</i>. TISSUE BARRIERS, 11(1). doi:10.1080/21688370.2022.2073175
2022
Cerebrovascular damage caused by the gut microbe/host co-metabolite<i>p</i>-cresol sulfate is prevented by blockade of the EGF receptor
A host–gut microbial co-metabolite of aromatic amino acids, <i>p</i>-cresol glucuronide, promotes blood–brain barrier integrity <i>in vivo</i>
2021
Synthesis, antiviral activity, preliminary pharmacokinetics and structural parameters of thiazolide amine salts
Stachulski, A. V., Rossignol, J. -F., Pate, S., Taujanskas, J., Robertson, C. M., Aerts, R., . . . O'Neill, P. M. (2021). Synthesis, antiviral activity, preliminary pharmacokinetics and structural parameters of thiazolide amine salts. FUTURE MEDICINAL CHEMISTRY, 13(20). doi:10.4155/fmc-2021-0055
Discovery and Optimization of a 4-Aminopiperidine Scaffold for Inhibition of Hepatitis C Virus Assembly
Rolt, A., Talley, D. C., Park, S. B., Hu, Z., Dulcey, A., Ma, C., . . . Marugan, J. J. (2021). Discovery and Optimization of a 4-Aminopiperidine Scaffold for Inhibition of Hepatitis C Virus Assembly. JOURNAL OF MEDICINAL CHEMISTRY, 64(13), 9431-9443. doi:10.1021/acs.jmedchem.1c00696
Systemic efficacy on <i>Cryptosporidium parvum</i> infection of aminoxanide (RM-5061), a new amino-acid ester thiazolide prodrug of tizoxanide
Diawara, E. H., Francois, A., Stachulski, A. V., Razakandrainibe, R., Costa, D., Favennec, L., . . . Gargala, G. (2021). Systemic efficacy on <i>Cryptosporidium parvum</i> infection of aminoxanide (RM-5061), a new amino-acid ester thiazolide prodrug of tizoxanide. PARASITOLOGY, 148(8), 975-984. doi:10.1017/S0031182021000524
Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2?
Stachulski, A. V., Taujanskas, J., Pate, S. L., Rajoli, R. K. R., Aljayyoussi, G., Pennington, S. H., . . . O'Neill, P. M. (2021). Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2?. ACS INFECTIOUS DISEASES, 7(6), 1317-1331. doi:10.1021/acsinfecdis.0c00478
Synthesis and toxicity profile in 293 human embryonic kidney cells of the β D-glucuronide derivatives of <i>ortho</i>-<i>, meta</i>- and <i>para</i>-cresol
London, J. A., Wang, E. C. S., Barsukov, I. L., Yates, E. A., & Stachulski, A. V. (2021). Synthesis and toxicity profile in 293 human embryonic kidney cells of the β D-glucuronide derivatives of <i>ortho</i>-<i>, meta</i>- and <i>para</i>-cresol. CARBOHYDRATE RESEARCH, 499. doi:10.1016/j.carres.2020.108225
2020
Acyl glucuronide reactivity in perspective
Bradshaw, P. R., Athersuch, T. J., Stachulski, A. V., & Wilson, I. D. (2020). Acyl glucuronide reactivity in perspective. DRUG DISCOVERY TODAY, 25(9), 1639-1650. doi:10.1016/j.drudis.2020.07.009
Kinetic modelling of acyl glucuronide and glucoside reactivity and development of structure-property relationships.
Bradshaw, P. R., Richards, S. E., Wilson, I. D., Stachulski, A. V., Lindon, J. C., & Athersuch, T. J. (2020). Kinetic modelling of acyl glucuronide and glucoside reactivity and development of structure-property relationships.. Organic & biomolecular chemistry. doi:10.1039/c9ob02008j
2019
Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR
Rolt, A., O'Neill, P. M., Liang, T. J., & Stachulski, A. V. (2019). Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR. RSC ADVANCES, 9(69), 40336-40339. doi:10.1039/c9ra08256e
2018
Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus
Stachulski, A. V., Santoro, M. G., Piacentini, S., Belardo, G., La Frazia, S., Pidathala, C., . . . Rossignol, J. -F. (2018). Second-generation nitazoxanide derivatives: thiazolides are effective inhibitors of the influenza A virus. FUTURE MEDICINAL CHEMISTRY, 10(8), 851-862. doi:10.4155/fmc-2017-0217
2017
Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis.
Hong, W. D., Gibbons, P. D., Leung, S. C., Amewu, R., Stocks, P. A., Stachulski, A. V., . . . Nixon, G. L. (2017). Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis.. Journal of medicinal chemistry, 60(9), 3703-3726. doi:10.1021/acs.jmedchem.6b01718
Synthesis and pre-clinical studies of new amino-acid ester thiazolide prodrugs
Stachulski, A. V., Swift, K., Cooper, M., Reynolds, S., Norton, D., Slonecker, S. D., & Rossignol, J. -F. (2017). Synthesis and pre-clinical studies of new amino-acid ester thiazolide prodrugs. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 126, 154-159. doi:10.1016/j.ejmech.2016.09.080
2014
ChemInform Abstract: Convenient Syntheses of Halo‐Dibenz[b,f]azepines and Carbamazepine Analogues via N‐Arylindoles.
Elliott, E., Maggs, J. L., Park, B. K., O'Neill, P. M., & Stachulski, A. V. (2014). ChemInform Abstract: Convenient Syntheses of Halo‐Dibenz[b,f]azepines and Carbamazepine Analogues via N‐Arylindoles.. ChemInform, 45(17). doi:10.1002/chin.201417186
Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein
Monrad, R. N., Errey, J. C., Barry, C. S., Iqbal, M., Meng, X., Iddon, L., . . . Davis, B. G. (2014). Dissecting the reaction of Phase II metabolites of ibuprofen and other NSAIDS with human plasma protein. CHEMICAL SCIENCE, 5(10), 3789-3794. doi:10.1039/c4sc01329h
Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients
Hammond, T. G., Meng, X., Jenkins, R. E., Maggs, J. L., Castelazo, A. S., Regan, S. L., . . . Williams, D. P. (2014). Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from a Drug Acyl Glucuronide Metabolite: Multiple Albumin Adductions in Diclofenac Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 350(2), 387-402. doi:10.1124/jpet.114.215079
2013
Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles.
Elliott, E. -C., Maggs, J. L., Park, B. K., O'Neill, P. M., & Stachulski, A. V. (2013). Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles.. Organic & biomolecular chemistry, 11(48), 8426-8434. doi:10.1039/c3ob41252k
The Generation, Detection, and Effects of Reactive Drug Metabolites
Stachulski, A. V., Baillie, T. A., Park, B. K., Obach, R. S., Dalvie, D. K., Williams, D. P., . . . Lennard, M. S. (2013). The Generation, Detection, and Effects of Reactive Drug Metabolites. MEDICINAL RESEARCH REVIEWS, 33(5), 985-1080. doi:10.1002/med.21273
Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides.
Stachulski, A. V., & Meng, X. (2013). Glucuronides from metabolites to medicines: a survey of the in vivo generation, chemical synthesis and properties of glucuronides.. Natural product reports, 30(6), 806-848. doi:10.1039/c3np70003h
Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives
Farrell, J., Lichtenfels, M., Sullivan, A., Elliott, E. C., Alfirevic, A., Stachulski, A. V., . . . Park, B. K. (2013). Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 132(2), 493-495. doi:10.1016/j.jaci.2013.02.045
2012
Haloarene Derivatives of Carbamazepine with Reduced Bioactivation Liabilities: 2-Monohalo and 2,8-Dihalo Derivatives
Elliott, E. -C., Regan, S. L., Maggs, J. L., Bowkett, E. R., Parry, L. J., Williams, D. P., . . . Stachulski, A. V. (2012). Haloarene Derivatives of Carbamazepine with Reduced Bioactivation Liabilities: 2-Monohalo and 2,8-Dihalo Derivatives. JOURNAL OF MEDICINAL CHEMISTRY, 55(22), 9773-9784. doi:10.1021/jm301013n
ChemInform Abstract: Convenient Synthesis of Benzo‐Fluorinated Dibenz[b,f]azepines: Rearrangements of Isatins, Acridines, and Indoles.
Elliott, E., Bowkett, E. R., Maggs, J. L., Bacsa, J., Park, B. K., Regan, S. L., . . . Stachulski, A. V. (2012). ChemInform Abstract: Convenient Synthesis of Benzo‐Fluorinated Dibenz[b,f]azepines: Rearrangements of Isatins, Acridines, and Indoles.. ChemInform, 43(7). doi:10.1002/chin.201207176
2011
Thiazolides as Novel Antiviral Agents. 2. Inhibition of Hepatitis C Virus Replication
Stachulski, A. V., Pidathala, C., Row, E. C., Sharma, R., Berry, N. G., Lawrenson, A. S., . . . Rossignol, J. -F. (2011). Thiazolides as Novel Antiviral Agents. 2. Inhibition of Hepatitis C Virus Replication. JOURNAL OF MEDICINAL CHEMISTRY, 54(24), 8670-8680. doi:10.1021/jm201264t
Convenient syntheses of benzo-fluorinated dibenz[b,f]azepines: rearrangements of isatins, acridines, and indoles.
Elliott, E. -C., Bowkett, E. R., Maggs, J. L., Bacsa, J., Park, B. K., Regan, S. L., . . . Stachulski, A. V. (2011). Convenient syntheses of benzo-fluorinated dibenz[b,f]azepines: rearrangements of isatins, acridines, and indoles.. Organic letters, 13(20), 5592-5595. doi:10.1021/ol202318w
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. The Journal of Pharmacology and Experimental Therapeutics, 338(3), 841-849. doi:10.1124/jpet.111.183871
Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients
Meng, X., Jenkins, R. E., Berry, N. G., Maggs, J. L., Farrell, J., Lane, C. S., . . . Park, B. K. (2011). Direct Evidence for the Formation of Diastereoisomeric Benzylpenicilloyl Haptens from Benzylpenicillin and Benzylpenicillenic Acid in Patients. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338(3), 841-849. doi:10.1124/jpet.111.183871
Thiazolides as Novel Antiviral Agents. 1. Inhibition of Hepatitis B Virus Replication
Stachulski, A. V., Pidathala, C., Row, E. C., Sharma, R., Berry, N. G., Iqbal, M., . . . Rossignol, J. -F. (2011). Thiazolides as Novel Antiviral Agents. 1. Inhibition of Hepatitis B Virus Replication. JOURNAL OF MEDICINAL CHEMISTRY, 54(12), 4119-4132. doi:10.1021/jm200153p
Chemistry and reactivity of acyl glucuronides.
Stachulski, A. V. (2011). Chemistry and reactivity of acyl glucuronides.. Current drug metabolism, 12(3), 215-221. doi:10.2174/138920011795101822
Recent Drug Discovery against <i>Cryptosporidium</i>
Rossignol, J., Semple, J. E., Stachulski, A. V., & Gargala, G. (2011). Recent Drug Discovery against <i>Cryptosporidium</i>. In Unknown Book (pp. 493-512). Wiley. doi:10.1002/9783527633883.ch27
Synthesis of a series of phenylacetic acid 1-β-<i>O</i>-acyl glucosides and comparison of their acyl migration and hydrolysis kinetics with the corresponding acyl glucuronides
Iddon, L., Richards, S. E., Johnson, C. H., Harding, J. R., Wilson, I. D., Nicholson, J. K., . . . Stachulski, A. V. (2011). Synthesis of a series of phenylacetic acid 1-β-<i>O</i>-acyl glucosides and comparison of their acyl migration and hydrolysis kinetics with the corresponding acyl glucuronides. ORGANIC & BIOMOLECULAR CHEMISTRY, 9(3), 926-934. doi:10.1039/c0ob00820f
Thiazolides as Novel Antiviral Agents. 1. Inhibition of Hepatitis B Virus Replication
Stachulski, A. V., Pidathala, C., Row, E. C., Sharma, R., Berry, N. G., Iqbal, M., . . . Rossignol, J. -F. (2011). Thiazolides as Novel Antiviral Agents. 1. Inhibition of Hepatitis B Virus Replication. Journal of Medicinal Chemistry,, 54, 4119-4132.
2010
The metabolism of carbamazepine in fresh rodent hepatocyte suspensions: The effect of bromine substitution on metabolism
Regan, S., Elliot, E., Maggs, J., Stachulski, A., Williams, D., & Park, K. (2010). The metabolism of carbamazepine in fresh rodent hepatocyte suspensions: The effect of bromine substitution on metabolism. In TOXICOLOGY Vol. 278 (pp. 358). doi:10.1016/j.tox.2010.08.109
High-performance liquid chromatography/mass spectrometric and proton nuclear magnetic resonance spectroscopic studies of the transacylation and hydrolysis of the acyl glucuronides of a series of phenylacetic acids in buffer and human plasma.
Karlsson, E. S., Johnson, C. H., Sarda, S., Iddon, L., Iqbal, M., Meng, X., . . . Lindon, J. C. (2010). High-performance liquid chromatography/mass spectrometric and proton nuclear magnetic resonance spectroscopic studies of the transacylation and hydrolysis of the acyl glucuronides of a series of phenylacetic acids in buffer and human plasma.. Rapid communications in mass spectrometry : RCM, 24(20), 3043-3051. doi:10.1002/rcm.4740
Corrigendum to “Syntheses of structurally diverse amino acids, including δ-hydroxylysine, using the acyl nitroso Diels–Alder reaction” [Tetrahedron Lett. 51 (2010) 2160]
Bollans, L., Bacsa, J., O’Farrell, D. J., Waterson, S., & Stachulski, A. V. (2010). Corrigendum to “Syntheses of structurally diverse amino acids, including δ-hydroxylysine, using the acyl nitroso Diels–Alder reaction” [Tetrahedron Lett. 51 (2010) 2160]. Tetrahedron Letters, 51(23), 3159. doi:10.1016/j.tetlet.2010.04.058
Synthesis, <i>in vitro</i> and <i>in vivo</i> antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared <i>via</i> thiol-olefin co-oxygenation (TOCO) of allylic alcohols
Amewu, R., Gibbons, P., Mukhtar, A., Stachulski, A. V., Ward, S. A., Hall, C., . . . O'Neill, P. M. (2010). Synthesis, <i>in vitro</i> and <i>in vivo</i> antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared <i>via</i> thiol-olefin co-oxygenation (TOCO) of allylic alcohols. ORGANIC & BIOMOLECULAR CHEMISTRY, 8(9), 2068-2077. doi:10.1039/b924319d
Syntheses of structurally diverse amino acids, including δ-hydroxylysine, using the acyl nitroso Diels–Alder reaction
Bollans, L., Bacsa, J., O’Farrell, D. A., Waterson, S., & Stachulski, A. V. (2010). Syntheses of structurally diverse amino acids, including δ-hydroxylysine, using the acyl nitroso Diels–Alder reaction. Tetrahedron Letters, 51(16), 2160-2163. doi:10.1016/j.tetlet.2010.02.076
Evaluation of new thiazolide/thiadiazolide derivatives reveals nitro group-independent efficacy against in vitro development of Cryptosporidium parvum.
Gargala, G., Le Goff, L., Ballet, J. -J., Favennec, L., Stachulski, A. V., & Rossignol, J. -F. (2010). Evaluation of new thiazolide/thiadiazolide derivatives reveals nitro group-independent efficacy against in vitro development of Cryptosporidium parvum.. Antimicrobial agents and chemotherapy, 54(3), 1315-1318. doi:10.1128/aac.00614-09
Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.
Pacorel, B., Leung, S. C., Stachulski, A. V., Davies, J., Vivas, L., Lander, H., . . . O'Neill, P. M. (2010). Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.. Journal of medicinal chemistry, 53(2), 633-640. doi:10.1021/jm901216v
A convenient new synthesis of quaternary ammonium glucuronides of drug molecules
Iddon, L., Bragg, R. A., Harding, J. R., & Stachulski, A. V. (2010). A convenient new synthesis of quaternary ammonium glucuronides of drug molecules. Tetrahedron, 66(2), 537-541. doi:10.1016/j.tet.2009.10.113
Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides.
Johnson, C. H., Karlsson, E., Sarda, S., Iddon, L., Iqbal, M., Meng, X., . . . Lindon, J. C. (2010). Integrated HPLC-MS and (1)H-NMR spectroscopic studies on acyl migration reaction kinetics of model drug ester glucuronides.. Xenobiotica; the fate of foreign compounds in biological systems, 40(1), 9-23. doi:10.3109/00498250903348720
2009
Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases.
Heyes, D. J., Levy, C., Lafite, P., Roberts, I. S., Goldrick, M., Stachulski, A. V., . . . Leys, D. (2009). Structure-based mechanism of CMP-2-keto-3-deoxymanno-octulonic acid synthetase: convergent evolution of a sugar-activating enzyme with DNA/RNA polymerases.. The Journal of biological chemistry, 284(51), 35514-35523. doi:10.1074/jbc.m109.056630
ChemInform Abstract: Syntheses and Structures of Anomeric Quaternary Ammonium β‐Glucosides and Comments on the Anomeric C—N Bonds Lengths.
Iddon, L., Bragg, R. A., Harding, J. R., Pidathala, C., Bacsa, J., Kirby, A. J., & Stachulski, A. V. (2009). ChemInform Abstract: Syntheses and Structures of Anomeric Quaternary Ammonium β‐Glucosides and Comments on the Anomeric C—N Bonds Lengths.. ChemInform, 40(47). doi:10.1002/chin.200947178
The acyl nitroso Diels-Alder (ANDA) reaction of sorbate derivatives: an X-ray and <SUP>15</SUP>N NMR study with an application to amino-acid synthesis
Bollans, L., Bacsa, J., Iggo, J. A., Morris, G. A., & Stachulski, A. V. (2009). The acyl nitroso Diels-Alder (ANDA) reaction of sorbate derivatives: an X-ray and <SUP>15</SUP>N NMR study with an application to amino-acid synthesis. ORGANIC & BIOMOLECULAR CHEMISTRY, 7(21), 4531-4538. doi:10.1039/b912963d
Convenient syntheses of the in vivo carbohydrate metabolites of mycophenolic acid: reactivity of the acyl glucuronide
Jones, A. E., Wilson, H. K., Meath, P., Meng, X., Holt, D. W., Johnston, A., . . . Stachulski, A. V. (2009). Convenient syntheses of the in vivo carbohydrate metabolites of mycophenolic acid: reactivity of the acyl glucuronide. Tetrahedron Letters, 50(35), 4973-4977. doi:10.1016/j.tetlet.2009.06.060
Syntheses and structures of anomeric quaternary ammonium β-glucosides and comments on the anomeric C–N bond lengths
Iddon, L., Bragg, R. A., Harding, J. R., Pidathala, C., Bacsa, J., Kirby, A. J., & Stachulski, A. V. (2009). Syntheses and structures of anomeric quaternary ammonium β-glucosides and comments on the anomeric C–N bond lengths. Tetrahedron, 65(32), 6396-6402. doi:10.1016/j.tet.2009.05.086
Synthesis, transacylation kinetics and computational chemistry of a set of arylacetic acid 1β-<i>O</i>-acyl glucuronides
Berry, N. G., Iddon, L., Iqbal, M., Meng, X., Jayapal, P., Johnson, C. H., . . . Stachulski, A. V. (2009). Synthesis, transacylation kinetics and computational chemistry of a set of arylacetic acid 1β-<i>O</i>-acyl glucuronides. ORGANIC & BIOMOLECULAR CHEMISTRY, 7(12), 2525-2533. doi:10.1039/b822777b
In vitro efficacy of nitro- and halogeno-thiazolide/thiadiazolide derivatives against Sarcocystis neurona.
Gargala, G., Le Goff, L., Ballet, J. J., Favennec, L., Stachulski, A. V., & Rossignol, J. F. (2009). In vitro efficacy of nitro- and halogeno-thiazolide/thiadiazolide derivatives against Sarcocystis neurona.. Veterinary parasitology, 162(3-4), 230-235. doi:10.1016/j.vetpar.2009.03.022
2008
Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: application to acyl glucuronide intramolecular transacylation reactions.
Johnson, C. H., Athersuch, T. J., Wilson, I. D., Iddon, L., Meng, X., Stachulski, A. V., . . . Nicholson, J. K. (2008). Kinetic and J-resolved statistical total correlation NMR spectroscopy approaches to structural information recovery in complex reacting mixtures: application to acyl glucuronide intramolecular transacylation reactions.. Analytical chemistry, 80(13), 4886-4895. doi:10.1021/ac702614t
2007
Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis.
Meng, X., Maggs, J. L., Pryde, D. C., Planken, S., Jenkins, R. E., Peakman, T. M., . . . Stachulski, A. V. (2007). Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: synthesis, reactivity, and mechanistic analysis.. Journal of medicinal chemistry, 50(24), 6165-6176. doi:10.1021/jm0706766
NMR spectroscopic studies on the in vitro acyl glucuronide migration kinetics of lbuprofen ((±)-(R,S)-2-(4-Isobutylphenyl) propanoic acid), its metabolites, and analogues
Johnson, C. H., Wilson, I. D., Harding, J. R., Stachulski, A. V., Iddon, L., Nicholson, J. K., & Lindon, J. C. (2007). NMR spectroscopic studies on the in vitro acyl glucuronide migration kinetics of lbuprofen ((±)-(R,S)-2-(4-Isobutylphenyl) propanoic acid), its metabolites, and analogues. ANALYTICAL CHEMISTRY, 79(22), 8720-8727. doi:10.1021/ac071368i
Efficient synthesis of 1β-O-acyl glucuronides via selective acylation of allyl or benzyl d-glucuronate
Bowkett, E. R., Harding, J. R., Maggs, J. L., Park, B. K., Perrie, J. A., & Stachulski, A. V. (2007). Efficient synthesis of 1β-O-acyl glucuronides via selective acylation of allyl or benzyl d-glucuronate. Tetrahedron, 63(32), 7596-7605. doi:10.1016/j.tet.2007.05.050
Design and Synthesis of Orally Active Dispiro 1,2,4,5‐Tetraoxanes; Synthetic Antimalarials with Superior Activity to Artemisinin.
Amewu, R., Stachulski, A. V., Ward, S. A., Berry, N. G., Bray, P. G., Davies, J., . . . O'Neill, P. M. (2007). Design and Synthesis of Orally Active Dispiro 1,2,4,5‐Tetraoxanes; Synthetic Antimalarials with Superior Activity to Artemisinin.. ChemInform, 38(13). doi:10.1002/chin.200713173
Convenient syntheses of deoxypyranose sugars from glucuronolactone
Stanford (nee Sinnott), D., & Stachulski, A. V. (2007). Convenient syntheses of deoxypyranose sugars from glucuronolactone. Tetrahedron Letters, 48(13), 2361-2364. doi:10.1016/j.tetlet.2007.01.127
Synthesis of 1,2,4‐Trioxepanes via Application of Thiol‐Olefin Co‐Oxygenation Methodology.
Amewu, R., Stachulski, A. V., Berry, N. G., Ward, S. A., Davies, J., Labat, G., . . . O'Neill, P. M. (2007). Synthesis of 1,2,4‐Trioxepanes via Application of Thiol‐Olefin Co‐Oxygenation Methodology.. ChemInform, 38(11). doi:10.1002/chin.200711148
Back matter
Back matter (2007). Organic & Biomolecular Chemistry, 5(4), 708. doi:10.1039/b701157c
Investigation of the immunogenicity of diclofenac and diclofenac metabolites
Naisbitt, D. J., Sanderson, L. S., Meng, X., Stachulski, A. V., Clarke, S. E., & Park, B. K. (2007). Investigation of the immunogenicity of diclofenac and diclofenac metabolites. TOXICOLOGY LETTERS, 168(1), 45-50. doi:10.1016/j.toxlet.2006.10.014
The chemistry and biological activity of acyl glucuronides.
Stachulski, A. V. (2007). The chemistry and biological activity of acyl glucuronides.. Current opinion in drug discovery & development, 10(1), 58-66.
2006
Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin
Amewu, R., Stachulski, A. V., Ward, S. A., Berry, N. G., Bray, P. G., Davies, J., . . . O'Neill, P. M. (2006). Design and synthesis of orally active dispiro 1,2,4,5-tetraoxanes; synthetic antimalarials with superior activity to artemisinin. ORGANIC & BIOMOLECULAR CHEMISTRY, 4(24), 4431-4436. doi:10.1039/b613565j
Synthesis of 1,2,4-trioxepanes via application of thiol-olefin Co-oxygenation methodology
Amewu, R., Stachulski, A. V., Berry, N. G., Ward, S. A., Davies, J., Labat, G., . . . O'Neill, P. M. (2006). Synthesis of 1,2,4-trioxepanes via application of thiol-olefin Co-oxygenation methodology. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(23), 6124-6130. doi:10.1016/j.bmcl.2006.08.098
Acyl glucuronides: Biological activity, chemical reactivity, and chemical synthesis
Stachulski, A. V., Harding, J. R., Lindon, J. C., Maggs, J. L., Park, B. K., & Wilson, I. D. (2006). Acyl glucuronides: Biological activity, chemical reactivity, and chemical synthesis. JOURNAL OF MEDICINAL CHEMISTRY, 49(24), 6931-6945. doi:10.1021/jm060599z
Activation of T cells by carbamazepine and carbamazepine metabolites
Wu, Y., Sanderson, J. P., Farrell, J., Drummond, N. S., Hanson, A., Bowkett, E., . . . Naisbitt, D. J. (2006). Activation of T cells by carbamazepine and carbamazepine metabolites. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 118(1), 233-241. doi:10.1016/j.jaci.2006.03.005
Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4.
Row, E. C., Brown, S. A., Stachulski, A. V., & Lennard, M. S. (2006). Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4.. Bioorganic & medicinal chemistry, 14(11), 3865-3871. doi:10.1016/j.bmc.2006.01.046
Design, synthesis and evaluation of furanocoumarin monomers as inhibitors of CYP3A4.
Row, E. C., Brown, S. A., Stachulski, A. V., & Lennard, M. S. (2006). Design, synthesis and evaluation of furanocoumarin monomers as inhibitors of CYP3A4.. Organic & biomolecular chemistry, 4(8), 1604-1610. doi:10.1039/b601096b
Identification of isoflavone derivatives as effective anticryptosporidial agents in vitro and in vivo
Stachulski, A. V., Berry, N. G., Low, A. C. L., Moores, S. L., Row, E., Warhurst, D. C., . . . Rossignol, J. F. (2006). Identification of isoflavone derivatives as effective anticryptosporidial agents in vitro and in vivo. JOURNAL OF MEDICINAL CHEMISTRY, 49(4), 1450-1454. doi:10.1021/jm050973f
Development of novel furanocoumarin dimers as potent and selective inhibitors of CYP3A4.
Row, E., Brown, S. A., Stachulski, A. V., & Lennard, M. S. (2006). Development of novel furanocoumarin dimers as potent and selective inhibitors of CYP3A4.. Drug metabolism and disposition: the biological fate of chemicals, 34(2), 324-330. doi:10.1124/dmd.105.007294
Corrigendum to “New stable anomeric hydroperoxides derived from 2-deoxy-sugars; enantioselective epoxidation of 2-methyl-1,4-naphthoquinone”
Kośnik, W., Stachulski, A. V., & Chmielewski, M. (2006). Corrigendum to “New stable anomeric hydroperoxides derived from 2-deoxy-sugars; enantioselective epoxidation of 2-methyl-1,4-naphthoquinone”. Tetrahedron: Asymmetry, 17(2), 313. doi:10.1016/j.tetasy.2005.12.002
2005
In vitro efficacies of nitazoxanide and other thiazolides against <i>Neospora caninum</i> tachyzoites reveal antiparasitic activity independent of the nitro group
Esposito, M., Stettler, R., Moores, S. L., Pidathala, C., Müller, N., Stachulski, A., . . . Hemphill, A. (2005). In vitro efficacies of nitazoxanide and other thiazolides against <i>Neospora caninum</i> tachyzoites reveal antiparasitic activity independent of the nitro group. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 49(9), 3715-3723. doi:10.1128/AAC.49.9.3715-3723.2005
Effective synthesis of 1beta-acyl glucuronides by selective acylation.
Perrie, J. A., Harding, J. R., Holt, D. W., Johnston, A., Meath, P., & Stachulski, A. V. (2005). Effective synthesis of 1beta-acyl glucuronides by selective acylation.. Organic letters, 7(13), 2591-2594. doi:10.1021/ol0507165
New stable anomeric hydroperoxides derived from 2-deoxysugars; enantioselective epoxidation of 2-methyl-1,4-naphthoquinone
Kośnik, W., Stachulski, A. V., & Chmielewski, M. (2005). New stable anomeric hydroperoxides derived from 2-deoxysugars; enantioselective epoxidation of 2-methyl-1,4-naphthoquinone. Tetrahedron: Asymmetry, 16(11), 1975-1981. doi:10.1016/j.tetasy.2005.04.009
Glucuronidation of steroidal alcohols using iodosugar and imidate donors.
Harding, J. R., King, C. D., Perrie, J. A., Sinnott, D., & Stachulski, A. V. (2005). Glucuronidation of steroidal alcohols using iodosugar and imidate donors.. Organic & biomolecular chemistry, 3(8), 1501-1507. doi:10.1039/b412217h
The design and synthesis of novel anomeric hydroperoxides: influence of the carbohydrate residue in the enantioselective epoxidation of quinones
Bundu, A., Berry, N. G., Gill, C. D., Dxyer, C. L., Stachulski, A. V., Taylor, R. J. K., & Whittall, J. (2005). The design and synthesis of novel anomeric hydroperoxides: influence of the carbohydrate residue in the enantioselective epoxidation of quinones. TETRAHEDRON-ASYMMETRY, 16(1), 283-293. doi:10.1016/j.tetasy.2004.11.015
2004
Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac.
Kenny, J. R., Maggs, J. L., Meng, X., Sinnott, D., Clarke, S. E., Park, B. K., & Stachulski, A. V. (2004). Syntheses and characterization of the acyl glucuronide and hydroxy metabolites of diclofenac.. Journal of medicinal chemistry, 47(11), 2816-2825. doi:10.1021/jm030891w
An unsaturated peptidomimetic assembly derived from a carbohydrate.
Chung, Y. -K., Claridge, T. D. W., Fleet, G. W. J., Johnson, S. W., Jones, J. H., Lumbard, K. W., & Stachulski, A. V. (2004). An unsaturated peptidomimetic assembly derived from a carbohydrate.. Journal of peptide science : an official publication of the European Peptide Society, 10(1), 1-7. doi:10.1002/psc.488
2003
Glycosidation with a disarmed glycosyl iodide: promotion and scope.
Perrie, J. A., Harding, J. R., King, C., Sinnott, D., & Stachulski, A. V. (2003). Glycosidation with a disarmed glycosyl iodide: promotion and scope.. Organic letters, 5(24), 4545-4548. doi:10.1021/ol035475k
Preparation, X-ray structure and reactivity of a stable glycosyl iodide.
Bickley, J., Cottrell, J. A., Ferguson, J. R., Field, R. A., Harding, J. R., Hughes, D. L., . . . Stachulski, A. V. (2003). Preparation, X-ray structure and reactivity of a stable glycosyl iodide.. Chemical communications (Cambridge, England), (11), 1266-1267. doi:10.1039/b302629a
Structure-activity relationships of some opiate glycosides.
Stachulski, A. V., Scheinmann, F., Ferguson, J. R., Law, J. L., Lumbard, K. W., Hopkins, P., . . . Joel, S. P. (2003). Structure-activity relationships of some opiate glycosides.. Bioorganic & medicinal chemistry letters, 13(6), 1207-1214. doi:10.1016/s0960-894x(03)00056-8
Chemical Synthesis, Protein Reactivity and in vitro Cytotoxicity of Diclofenac Acyl Glucuronide'
Kenny, J. R., Stachulski, A. V., Maggs, J. L., Harrell, A. W., Clarke, S. E., & Park, B. K. (2003). Chemical Synthesis, Protein Reactivity and in vitro Cytotoxicity of Diclofenac Acyl Glucuronide'. Toxicolog, 192(1), 70.
2002
Synthesis of morphine‐[<i>N</i>‐methyl‐<sup>14</sup>C]‐6‐<i>β</i>‐<scp>D</scp>‐glucuronide
Ferguson, J. R., Hollis, S. J., Johnston, G. A., Lumbard, K. W., & Stachulski, A. V. (2002). Synthesis of morphine‐[<i>N</i>‐methyl‐<sup>14</sup>C]‐6‐<i>β</i>‐<scp>D</scp>‐glucuronide. Journal of Labelled Compounds and Radiopharmaceuticals, 45(2), 107-113. doi:10.1002/jlcr.540
2001
Erratum: Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin - Synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues (Journal of the Chemical Society. Perkin Transactions 1 (2001) (2682))
O'Neill, P. M., Pugh, M., Stachulski, A. V., Ward, S. A., Davies, J., & Park, B. K. (2001). Erratum: Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin - Synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues (Journal of the Chemical Society. Perkin Transactions 1 (2001) (2682)). Journal of the Chemical Society Perkin Transactions 1, (23), 3214.
Putative metabolites of fulvestrant, an estrogen receptor downregulator. Improved glucuronidation using trichloroacetimidates
Ferguson, J. R., Harding, J. R., Killick, D. A., Lumbard, K. W., Scheinmann, F., & Stachulski, A. V. (2001). Putative metabolites of fulvestrant, an estrogen receptor downregulator. Improved glucuronidation using trichloroacetimidates. Journal of the Chemical Society, Perkin Transactions 1, (22), 3037-3041. doi:10.1039/b105397n
Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin: synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues
O'Neill, P. M., Pugh, M., Stachulski, A. V., Ward, S. A., Davies, J., & Park, B. K. (2001). Optimisation of the allylsilane approach to C-10 deoxo carba analogues of dihydroartemisinin: synthesis and in vitro antimalarial activity of new, metabolically stable C-10 analogues. Journal of the Chemical Society, Perkin Transactions 1, (20), 2682-2689. doi:10.1039/b104340b
Glucuronidation of alcohols using the bromosugar–iodonium reagent method
Stachulski, A. V. (2001). Glucuronidation of alcohols using the bromosugar–iodonium reagent method. Tetrahedron Letters, 42(37), 6611-6613. doi:10.1016/s0040-4039(01)01333-8
Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite.
O'Neill, P. M., Scheinmann, F., Stachulski, A. V., Maggs, J. L., & Park, B. K. (2001). Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite.. Journal of medicinal chemistry, 44(9), 1467-1470. doi:10.1021/jm001061a
Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.
O'Neill, P. M., Miller, A., Bishop, L. P., Hindley, S., Maggs, J. L., Ward, S. A., . . . Park, B. K. (2001). Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.. Journal of medicinal chemistry, 44(1), 58-68. doi:10.1021/jm000987f
The Synthesis of the Glucuronide Metabolite of UK-157,147 Using Immobilised Uridine 5′-Diphosphoglucuronyl Transferase and Traditional Organic Chemistry Techniques (Imidate Method)
Webster, R., Beaumont, K., Ritzau, M., & Stachulski, A. V. (2001). The Synthesis of the Glucuronide Metabolite of UK-157,147 Using Immobilised Uridine 5′-Diphosphoglucuronyl Transferase and Traditional Organic Chemistry Techniques (Imidate Method). Biocatalysis and Biotransformation, 19(1), 69-83. doi:10.3109/10242420109103517
2000
The enzymatic glucuronidation of 3-O-protected morphine—a new route to 7,8-dihydromorphine-6-glucuronide
Jenkins, G. N., Stachulski, A. V., Scheinmann, F., & Turner, N. J. (2000). The enzymatic glucuronidation of 3-O-protected morphine—a new route to 7,8-dihydromorphine-6-glucuronide. Tetrahedron: Asymmetry, 11(2), 413-416. doi:10.1016/s0957-4166(99)00582-0
Glucuronide and sulfate conjugates of ICI 182,780, a pure anti-estrogenic steroid. Order of addition, catalysis and substitution effects in glucuronidation
Ferguson, J. R., Harding, J. R., Lumbard, K. W., Scheinmann, F., & Stachulski, A. V. (2000). Glucuronide and sulfate conjugates of ICI 182,780, a pure anti-estrogenic steroid. Order of addition, catalysis and substitution effects in glucuronidation. Tetrahedron Letters, 41(3), 389-392. doi:10.1016/s0040-4039(99)02067-5
Drug Metabolism: The Body's Defense against Chemical Attack
Lennard, M. S., & Stachulski, A. V. (2000). Drug Metabolism: The Body's Defense against Chemical Attack. Journal of Chemical Education, 77(3), 349. doi:10.1021/ed077p349
1999
Application of the TMSOTfAgClO4 activator system to the synthesis of novel, potent, C-10 phenoxy derivatives of dihydroartemisinin
O'Neill, P. M., Miller, A., Ward, S. A., Park, B. K., Scheinmann, F., & Stachulski, A. V. (1999). Application of the TMSOTfAgClO4 activator system to the synthesis of novel, potent, C-10 phenoxy derivatives of dihydroartemisinin. Tetrahedron Letters, 40(51), 9129-9132. doi:10.1016/s0040-4039(99)01891-2
Syntheses and Antibacterial Activities of Tizoxanide, an N-(Nitrothiazolyl)salicylamide, and its O-Aryl Glucuronide
Rossignol, J. -F., & Stachulski, A. V. (1999). Syntheses and Antibacterial Activities of Tizoxanide, an N-(Nitrothiazolyl)salicylamide, and its O-Aryl Glucuronide. Journal of Chemical Research, (1), 44-45. doi:10.1039/a806676k
1998
The synthesis of O-glucuronides.
Stachulski, A. V., & Jenkins, G. N. (1998). The synthesis of O-glucuronides.. Natural product reports, 15(2), 173-186. doi:10.1039/a815173y
1997
Intermediates for Glucuronide Synthesis: 7-Hydroxycoumarin Glucuronide
Brown, R. T., Scheinmann, F., & Stachulski, A. V. (1997). Intermediates for Glucuronide Synthesis: 7-Hydroxycoumarin Glucuronide. Journal of Chemical Research Part S, (10), 370-371.
1996
Stereochemical and NMR Reassignment of 6-Norlysergic Acid Diethylamide and 6-Nor-6-allyllysergic Acid Diethylamide
Stachulski, A. V., Nichols, D. E., & Scheinmann, F. (1996). Stereochemical and NMR Reassignment of 6-Norlysergic Acid Diethylamide and 6-Nor-6-allyllysergic Acid Diethylamide. Journal of Chemical Research Part S, (1), 30-31.
1995
Efficient new syntheses of (+)- and (-)-anatoxin-a. Revised configuration of resolved 9-methyl-9-azabicyclo[4.2.1]nonan-2-one
Ferguson, J. R., Lumbard, K. W., Scheinmann, F., Stachulski, A. V., Stjernlöf, P., & Sundell, S. (1995). Efficient new syntheses of (+)- and (-)-anatoxin-a. Revised configuration of resolved 9-methyl-9-azabicyclo[4.2.1]nonan-2-one. Tetrahedron Letters, 36(48), 8867-8870. doi:10.1016/0040-4039(95)01842-6
1993
Stereoselective synthesis of BRL 56173, a bicyclic acrylic penicillin highly stable to beta-lactamases.
Atkins, R. J., Ponsford, R. J., & Stachulski, A. V. (1993). Stereoselective synthesis of BRL 56173, a bicyclic acrylic penicillin highly stable to beta-lactamases.. The Journal of antibiotics, 46(2), 362-365. doi:10.7164/antibiotics.46.362
Synthesis and structure-activity relationships of some 6 beta-acrylamido penicillins.
Anderson, R. K., Chapman, P. C., Cosham, S. C., Davies, J. S., Grinter, T. J., Harris, M. A., . . . Smith, C. F. (1993). Synthesis and structure-activity relationships of some 6 beta-acrylamido penicillins.. The Journal of antibiotics, 46(2), 331-342. doi:10.7164/antibiotics.46.331
1991
Further synthetic studies in penicillin C(6)-substitution including the versatile 6α-succinimidooxy leaving group
Milner, P. H., & Stachulski, A. V. (1991). Further synthetic studies in penicillin C(6)-substitution including the versatile 6α-succinimidooxy leaving group. J. Chem. Soc., Perkin Trans. 1, (10), 2343-2352. doi:10.1039/p19910002343
Synthesis of O-vinyl oximes and derived penicillins using organoselenium intermediates
Stachulski, A. V. (1991). Synthesis of O-vinyl oximes and derived penicillins using organoselenium intermediates. Journal of the Chemical Society, Perkin Transactions 1, (12), 3065. doi:10.1039/p19910003065
1990
Aqueous and anhydrous degradations of 6α-formamidopenicillins
Cutmore, E. A., Guest, A. W., Hatto, J. D. I., Moores, C. J., Smale, T. C., Stachulski, A. V., & Tyler, J. W. (1990). Aqueous and anhydrous degradations of 6α-formamidopenicillins. Journal of the Chemical Society Perkin Transactions 1, (4), 847-853.
Structure-activity relationships of some arylglycine analogues and catechol isosteres of BRL 36650, a 6 alpha-formamido penicillin.
Best, D. J., Burton, G., Davies, D. T., Elder, J. S., Smale, T. C., Southgate, R., . . . Knott, S. J. (1990). Structure-activity relationships of some arylglycine analogues and catechol isosteres of BRL 36650, a 6 alpha-formamido penicillin.. The Journal of antibiotics, 43(5), 574-577. doi:10.7164/antibiotics.43.574
1988
Acetonitrile: an excellent solvent for the 1,1-dichloromethylenation of certain ketones
Burton, G., Elder, J. S., Fell, S. C. M., & Stachulski, A. V. (1988). Acetonitrile: an excellent solvent for the 1,1-dichloromethylenation of certain ketones. Tetrahedron Letters, 29(24), 3003-3006. doi:10.1016/0040-4039(88)85072-x
1987
Degradation of BRL 36650, a 6α-formamido penicillin: C(5)–C(6) bond cleavage
Cutmore, E. A., Guest, A. W., Hatto, J. D. I., Smale, T. C., Stachulski, A. V., & Tyler, J. W. (1987). Degradation of BRL 36650, a 6α-formamido penicillin: C(5)–C(6) bond cleavage. J. Chem. Soc., Chem. Commun., (1), 21-23. doi:10.1039/c39870000021
1986
Penicillin C-6 substitution using the versatile 6α-succinimido-oxy leaving group
Stachulski, A. V. (1986). Penicillin C-6 substitution using the versatile 6α-succinimido-oxy leaving group. J. Chem. Soc., Chem. Commun., (5), 401-402. doi:10.1039/c39860000401
Structure-activity relationships of some 6 alpha-formamido penicillins.
Guest, A. W., Harrington, F. P., Milner, P. H., Ponsford, R. J., Smale, T. C., Stachulski, A. V., . . . Slocombe, B. (1986). Structure-activity relationships of some 6 alpha-formamido penicillins.. The Journal of antibiotics, 39(10), 1498-1501. doi:10.7164/antibiotics.39.1498
1985
Penicillin C-6 substitution: a novel oxygen-bridged dimer
Stachulski, A. V. (1985). Penicillin C-6 substitution: a novel oxygen-bridged dimer. Tetrahedron Letters, 26(15), 1883-1884. doi:10.1016/s0040-4039(00)94764-6
1984
6α(7α)-Formamido penicillins and cephalosporins
Milner, P. H., Guest, A. W., Harrington, F. P., Ponsford, R. J., Smale, T. C., & Stachulski, A. V. (1984). 6α(7α)-Formamido penicillins and cephalosporins. J. Chem. Soc., Chem. Commun., (20), 1335-1336. doi:10.1039/c39840001335
The chemistry of some 2-aminothiazol-4-ylacetic acid derivatives and the synthesis of derived penicillins
Hardy, K. D., Harrington, F. P., & Stachulski, A. V. (1984). The chemistry of some 2-aminothiazol-4-ylacetic acid derivatives and the synthesis of derived penicillins. Journal of the Chemical Society, Perkin Transactions 1, 1227. doi:10.1039/p19840001227
1983
Biosynthesis. Part 26. Synthetic studies on structural modification of late biosynthetic precursors for colchicine
Battersby, A. R., McDonald, E., & Stachulski, A. V. (1983). Biosynthesis. Part 26. Synthetic studies on structural modification of late biosynthetic precursors for colchicine. Journal of the Chemical Society, Perkin Transactions 1, 3053. doi:10.1039/p19830003053
1982
Oxidation of benzyloxycarbonyl threonine and serine methyl esters to an oxamate derivative
Stachulski, A. V. (1982). Oxidation of benzyloxycarbonyl threonine and serine methyl esters to an oxamate derivative. Tetrahedron Letters, 23(37), 3789-3790. doi:10.1016/s0040-4039(00)87707-2
1979
Synthesis and biological activities of [7-(azetidine-2-carboxylic acid)]-oxytocin and -lysine-vasopressin.
Barber, M., Jones, J. H., Stachulski, A. V., Bisset, G. W., Chowdrey, H. S., & Hudson, A. L. (1979). Synthesis and biological activities of [7-(azetidine-2-carboxylic acid)]-oxytocin and -lysine-vasopressin.. International journal of peptide and protein research, 14(3), 247-261. doi:10.1111/j.1399-3011.1979.tb01931.x
The use of the N(π)-phenacyl group for the protection of the histidine side chain in peptide synthesis
Fletcher, A. R., Jones, J. H., Ramage, W. I., & Stachulski, A. V. (1979). The use of the N(π)-phenacyl group for the protection of the histidine side chain in peptide synthesis. J. Chem. Soc., Perkin Trans. 1, (0), 2261-2267. doi:10.1039/p19790002261