Research outputs
2026
Translating in vitro buccal permeation to in vivo and whole‑body exposure using in silico cell‑based and physiologically-based pharmacokinetic modelling
Edwards, S. M., Harding, A. L., Leedale, J. A., Webb, S. D., Colley, H. E., Byers, R. A., . . . Murdoch, C. (2026). Translating in vitro buccal permeation to in vivo and whole‑body exposure using in silico cell‑based and physiologically-based pharmacokinetic modelling. International Journal of Pharmaceutics, 126701. doi:10.1016/j.ijpharm.2026.126701
2024
An advanced in silico model of the oral mucosa reveals the impact of extracellular spaces on chemical permeation
Edwards, S. M., Harding, A. L., Leedale, J. A., Webb, S. D., Colley, H. E., Murdoch, C., & Bearon, R. N. (2024). An advanced in silico model of the oral mucosa reveals the impact of extracellular spaces on chemical permeation. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 666. doi:10.1016/j.ijpharm.2024.124827
Highly porous polycaprolactone microspheres for skeletal repair promote a mature bone cell phenotype <i>in vitro</i>
Paterson, T. E., Owen, R., Sherborne, C., Bahmaee, H., Harding, A. L., Green, N. H., . . . Claeyssens, F. (2024). Highly porous polycaprolactone microspheres for skeletal repair promote a mature bone cell phenotype <i>in vitro</i>. JOURNAL OF MATERIALS CHEMISTRY B, 12(45), 11746-11758. doi:10.1039/d4tb01532k
Feeder-free culture of human pluripotent stem cells drives MDM4-mediated gain of chromosome 1q
Stavish, D., Price, C. J., Gelezauskaite, G., Alsehli, H., Leonhard, K. A., Taapken, S. M., . . . Barbaric, I. (2024). Feeder-free culture of human pluripotent stem cells drives MDM4-mediated gain of chromosome 1q. STEM CELL REPORTS, 19(8), 1217-1232. doi:10.1016/j.stemcr.2024.06.003
2023
c-Src activation as a potential marker of chemical-induced skin irritation using tissue-engineered skin equivalents
Harding, A. L., Colley, H. E., Vazquez, I. B., Danby, S., Hasan, M. Z., Nakanishi, H., . . . Murdoch, C. (2023). c-Src activation as a potential marker of chemical-induced skin irritation using tissue-engineered skin equivalents. EXPERIMENTAL DERMATOLOGY, 32(2), 220-225. doi:10.1111/exd.14719
2022
The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1
Waters, E., Wilkinson, K. A., Harding, A. L., Carmichael, R. E., Robinson, D., Colley, H. E., & Guo, C. (2022). The SUMO protease SENP3 regulates mitochondrial autophagy mediated by Fis1. EMBO REPORTS, 23(2). doi:10.15252/embr.201948754
2021
Determination of Chemical Irritation Potential Using a Defined Gene Signature Set on Tissue-Engineered Human Skin Equivalents
Harding, A. L., Murdoch, C., Danby, S., Hasan, M. Z., Nakanishi, H., Furuno, T., . . . Colley, H. E. (2021). Determination of Chemical Irritation Potential Using a Defined Gene Signature Set on Tissue-Engineered Human Skin Equivalents. JID INNOVATIONS, 1(2). doi:10.1016/j.xjidi.2021.100011
2020
Multiscale modelling of drug transport and metabolism in liver spheroids
Leedale, J. A., Kyffin, J., Harding, A., Colley, H., Murdoch, C., Sharma, P., . . . Bearon, R. (2020). Multiscale modelling of drug transport and metabolism in liver spheroids. Interface Focus, 10(2). doi:10.1098/rsfs.2019.0041
2019
Characterisation of a functional rat hepatocyte spheroid model
Kyffin, J. A., Sharma, P., Leedale, J., Colley, H. E., Murdoch, C., Harding, A. L., . . . Webb, S. D. (2019). Characterisation of a functional rat hepatocyte spheroid model. TOXICOLOGY IN VITRO, 55, 160-172. doi:10.1016/j.tiv.2018.12.014