Research outputs
Selected research outputs
- Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer (Journal article - 2018)
- Blockade of MIF-CD74 signalling on macrophages and dendritic cells restores the anti-tumour immune response against metastatic melanoma. (Journal article - 2018)
- Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors (Journal article - 2016)
- Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis (Journal article - 2016)
- Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer (Journal article - 2018)
- Blockade of Stromal Gas6 Alters Cancer Cell Plasticity, Activates NK Cells, and Inhibits Pancreatic Cancer Metastasis. (Journal article - 2020)
- Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis (Journal article - 2022)
- Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis (Journal article - 2024)
- Mesothelin secretion by pancreatic cancer cells co-opts macrophages and promotes metastasis (Journal article - 2024)
- Macrophages suppress CD8 + T cell cytotoxic function in triple negative breast cancer via VISTA (Journal article - 2025)
2025
Macrophages suppress CD8 + T cell cytotoxic function in triple negative breast cancer via VISTA
Mielgo Iza, A. (2025). Macrophages suppress CD8 + T cell cytotoxic function in triple negative breast cancer via VISTA. British Journal of Cancer. doi:10.1038/s41416-025-03013-5
2024
Expression of versican isoforms V0/V1 by pancreatic cancer associated fibroblasts increases fibroblast proliferation
Elhashani, S., Glenn, M., Raymant, M., Schmid, M. C., & Mielgo, A. (2024). Expression of versican isoforms V0/V1 by pancreatic cancer associated fibroblasts increases fibroblast proliferation. PANCREATOLOGY, 24(5), 719-731. doi:10.1016/j.pan.2024.04.008
Robust and consistent biomarker candidates identification by a machine learning approach applied to pancreatic ductal adenocarcinoma metastasis.
Mahawan, T., Luckett, T., Mielgo Iza, A., Pornputtapong, N., & Caamaño Gutiérrez, E. (2024). Robust and consistent biomarker candidates identification by a machine learning approach applied to pancreatic ductal adenocarcinoma metastasis.. BMC medical informatics and decision making, 24(Suppl 4), 175. doi:10.1186/s12911-024-02578-0
Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis
Astuti, Y., Raymant, M., Quaranta, V., Clarke, K., Abudula, M., Smith, O., . . . Schmid, M. C. (2024). Efferocytosis reprograms the tumor microenvironment to promote pancreatic cancer liver metastasis. NATURE CANCER, 5(5). doi:10.1038/s43018-024-00731-2
Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer.
Raymant, M., Astuti, Y., Alvaro-Espinosa, L., Green, D., Quaranta, V., Bellomo, G., . . . Schmid, M. C. (2024). Macrophage-fibroblast JAK/STAT dependent crosstalk promotes liver metastatic outgrowth in pancreatic cancer.. Nature communications, 15(1), 3593. doi:10.1038/s41467-024-47949-3
Inhibition of insulin-like growth factors increases production of CXCL9/10 by macrophages and fibroblasts and facilitates CD8+ cytotoxic T cell recruitment to pancreatic tumours
Freeman, P., Bellomo, G., Ireland, L., Abudula, M., Luckett, T., Oberst, M., . . . Mielgo, A. (2024). Inhibition of insulin-like growth factors increases production of CXCL9/10 by macrophages and fibroblasts and facilitates CD8+ cytotoxic T cell recruitment to pancreatic tumours. Frontiers in Immunology, 15. doi:10.3389/fimmu.2024.1382538
Mesothelin secretion by pancreatic cancer cells co-opts macrophages and promotes metastasis
Mielgo Iza, A. (2024). Mesothelin secretion by pancreatic cancer cells co-opts macrophages and promotes metastasis. Cancer Research. doi:10.1158/0008-5472.CAN-23-1542
2023
PINCER (A Platform Study for solId orgaN CancERs): an agile pan-network platform study to deliver high-quality translational research
Jones, R. P., Mielgo, A., Schmid, M., Bury, D., Andrews, T., Burdak-Rothkamm, S., . . . Vimalachandran, D. (2023). PINCER (A Platform Study for solId orgaN CancERs): an agile pan-network platform study to deliver high-quality translational research. BRITISH JOURNAL OF SURGERY. doi:10.1093/bjs/znad097
2022
Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis
Bellomo, G., Rainer, C., Quaranta, V., Astuti, Y., Raymant, M., Boyd, E., . . . Schmid, M. C. (2022). Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis. Gut. doi:10.1136/gutjnl-2021-325272
2020
Cancer-Associated Fibroblast Mediated Inhibition of CD8+ Cytotoxic T Cell Accumulation in Tumours: Mechanisms and Therapeutic Opportunities
Freeman, P., & Mielgo, A. (2020). Cancer-Associated Fibroblast Mediated Inhibition of CD8+ Cytotoxic T Cell Accumulation in Tumours: Mechanisms and Therapeutic Opportunities. Cancers, 12(9), 2687. doi:10.3390/cancers12092687
Blockade of Stromal Gas6 Alters Cancer Cell Plasticity, Activates NK Cells, and Inhibits Pancreatic Cancer Metastasis.
Ireland, L., Luckett, T., Schmid, M. C., & Mielgo, A. (2020). Blockade of Stromal Gas6 Alters Cancer Cell Plasticity, Activates NK Cells, and Inhibits Pancreatic Cancer Metastasis.. Frontiers in Immunology, 11. doi:10.3389/fimmu.2020.00297
2019
Blockade of stromal Gas6 alters cancer cell plasticity, activates NK cells and inhibits pancreatic cancer metastasis
Ireland, L., Luckett, T., Schmid, M. C., & Mielgo, A. (2019). Blockade of stromal Gas6 alters cancer cell plasticity, activates NK cells and inhibits pancreatic cancer metastasis. doi:10.1101/732149
2018
Macrophages and Fibroblasts, Key Players in Cancer Chemoresistance
Ireland, L. V., & Mielgo, A. (2018). Macrophages and Fibroblasts, Key Players in Cancer Chemoresistance. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 6. doi:10.3389/fcell.2018.00131
Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer
Quaranta, V., Rainer, C., Nielsen, S., Raymant, M., Ahmed, M., Engle, D., . . . Schmid, M. C. (2018). Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer. Cancer Research, 78(15), 4253-4269. doi:10.1158/0008-5472.CAN-17-3876
Blockade of MIF-CD74 signalling on macrophages and dendritic cells restores the anti-tumour immune response against metastatic melanoma.
Figueiredo, C., Azevedo, R., Mousdell, S., Resende-Lara, P., Ireland, L., Santos, A., . . . Mielgo Iza, A. (2018). Blockade of MIF-CD74 signalling on macrophages and dendritic cells restores the anti-tumour immune response against metastatic melanoma.. Frontiers in Immunology, 9. doi:10.3389/fimmu.2018.01132
Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer
Ireland, L., Santos, A., Campbell, F., Figueiredo, C., Hammond, D., Ellies, L. G., . . . Mielgo Iza, A. (2018). Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer. Oncogene, 37(15), 2022-2036. doi:10.1038/s41388-017-0115-x
2017
Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer
Ireland, L., Santos, A., Campbell, F., Figueiredo, C., Ellies, L., Weyer-Czernilofsky, U., . . . Mielgo, A. (2017). Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer. doi:10.1101/165068
2016
Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors
Ireland, L., Santos, A., Ahmed, M. S., Rainer, C., Nielsen, S. R., Quaranta, V., . . . Mielgo, A. (2016). Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors. Cancer Research, 76(23), 6851-6863. doi:10.1158/0008-5472.CAN-16-1201
Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis
Schmid, M. C., Nielsen, S. R., Quaranta, V., Rainer, C., Mielgo, A., Emeagi, P., . . . Engle, D. (2016). Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Nature Cell Biology, 18(5), 549-560. doi:10.1038/ncb3340
2015
Kinase-independent role for CRAF-driving tumour radioresistance via CHK2
Advani, S. J., Camargo, M. F., Seguin, L., Mielgo, A., Anand, S., Hicks, A. M., . . . Cheresh, D. A. (2015). Kinase-independent role for CRAF-driving tumour radioresistance via CHK2. Nature Communications, 6. doi:10.1038/ncomms9154
2014
An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.
Seguin, L., Kato, S., Franovic, A., Camargo, M. F., Lesperance, J., Elliott, K. C., . . . Cheresh, D. A. (2014). An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.. Nature Cell Biology, 16(5), 457-468. doi:10.1038/ncb2953
2013
Impact of tumour associated macrophages in pancreatic cancer
Mielgo, A., & Schmid, M. C. (2013). Impact of tumour associated macrophages in pancreatic cancer. BMB REPORTS, 46(3), 131-138. doi:10.5483/BMBRep.2013.46.3.036
2012
Caspase-8 isoform 6 promotes death effector filament formation independent of microtubules.
Yuan, R. T., Young, S., Liang, J., Schmid, M. C., Mielgo, A., & Stupack, D. G. (2012). Caspase-8 isoform 6 promotes death effector filament formation independent of microtubules.. Apoptosis..
2011
A MEK-independent role for CRAF in mitosis and tumor progression
Mielgo, A., Seguin, L., Huang, M., Camargo, M. F., Anand, S., Franovic, A., . . . Cheresh, D. A. (2011). A MEK-independent role for CRAF in mitosis and tumor progression. NATURE MEDICINE, 17(12), 1641-U156. doi:10.1038/nm.2464
Activated Src kinase accelerates KrasG12D-dependent pancreatic neoplasia and promotes oncogenic addiction.
Shields, D. J., Murphy, E., Desgrosellier, J. S., Mielgo, A., Barnes, L., Lesperance, J., . . . Cheresh., D. A. (2011). Activated Src kinase accelerates KrasG12D-dependent pancreatic neoplasia and promotes oncogenic addiction.. Oncogene.
2010
Rab5 Mediates Caspase-8-promoted Cell Motility and Metastasis
Torres, V. A., Mielgo, A., Barbero, S., Hsiao, R., Wilkins, J. A., & Stupack, D. G. (2010). Rab5 Mediates Caspase-8-promoted Cell Motility and Metastasis. MOLECULAR BIOLOGY OF THE CELL, 21(2), 369-376. doi:10.1091/mbc.E09-09-0769
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments
Tanjoni, I., Walsh, C., Uryu, S., Mielgo, A., Tomar, A., Nam, J. -O., . . . Schlaepfer, D. (2010). PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol. Ther.
Proc. Natl. Acad. Sci.
Shields, D. J., Niessen, S., Murphy, E., Mielgo, A., Barnes, L., Lesperance, J., . . . Cheresh., D. A. (2010). Proc. Natl. Acad. Sci..
2009
The Death Effector Domains of Caspase-8 Induce Terminal Differentiation
Mielgo, A., Torres, V. A., Schmid, M. C., Graf, R., Zeitlin, S. G., Lee, P., . . . Stupack, D. G. (2009). The Death Effector Domains of Caspase-8 Induce Terminal Differentiation. PLOS ONE, 4(11). doi:10.1371/journal.pone.0007879
Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules
Mielgo, A., Torres, V. A., Clair, K., Barbero, S., & Stupack, D. G. (2009). Paclitaxel promotes a caspase 8-mediated apoptosis through death effector domain association with microtubules. ONCOGENE, 28(40), 3551-3562. doi:10.1038/onc.2009.210
Caspase-8 Association with the Focal Adhesion Complex Promotes Tumor Cell Migration and Metastasis
Barbero, S., Mielgo, A., Torres, V., Teitz, T., Shields, D. J., Mikolon, D., . . . Stupack, D. G. (2009). Caspase-8 Association with the Focal Adhesion Complex Promotes Tumor Cell Migration and Metastasis. CANCER RESEARCH, 69(9), 3755-3763. doi:10.1158/0008-5472.CAN-08-3937
2008
Caspase 8 Promotes Peripheral Localization and Activation of Rab5
Torres, V. A., Mielgo, A., Barila, D., Anderson, D. H., & Stupack, D. (2008). Caspase 8 Promotes Peripheral Localization and Activation of Rab5. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(52), 36280-36289. doi:10.1074/jbc.M805878200
Identification of a critical tyrosine residue in caspase 8 that promotes cell migration
Barbero, S., Barila, D., Mielgo, A., Stagni, V., Clair, K., & Stupack, D. (2008). Identification of a critical tyrosine residue in caspase 8 that promotes cell migration. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(19), 13031-13034. doi:10.1074/jbc.M800549200
The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8
Wrasidlo, W., Mielgo, A., Torres, V. A., Barbero, S., Stoletov, K., Suyama, T. L., . . . Stupack, D. G. (2008). The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(7), 2313-2318. doi:10.1073/pnas.0712198105
Apoptosis and pathogenesis of melanoma and non-melanoma skin cancer.
Erb, P., Ji, J., Kump, E., Mielgo, A., & Wernli, M. (2008). Apoptosis and pathogenesis of melanoma and non-melanoma skin cancer.. Adv. Exp. Med. Biol..
Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility.
Wu, L., Bernard-Trifilo, J. A., lim, Y., Lim, S. -T., Mitra, S. K., Uryu, S., . . . Schlaepfer, D. D. (2008). Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility.. Oncogene.
2007
The CD44 standard/ezrin complex regulates Fas-mediated apoptosis in Jurkat cells
Mielgo, A., Brondani, V., Landmann, L., Glaser-Ruhm, A., Erb, P., Stupack, D., & Guenthert, U. (2007). The CD44 standard/ezrin complex regulates Fas-mediated apoptosis in Jurkat cells. APOPTOSIS, 12(11), 2051-2061. doi:10.1007/s10495-007-0115-3
2006
A novel antiapoptotic mechanism based on interference of Fas signaling by CD44 variant isoforms
Mielgo, A., van Driel, M., Bloem, A., Landmann, L., & Günthert, U. (2006). A novel antiapoptotic mechanism based on interference of Fas signaling by CD44 variant isoforms. CELL DEATH AND DIFFERENTIATION, 13(3), 465-477. doi:10.1038/sj.cdd.4401763
2005
Fas-ligand gene silencing in basal cell carcinoma tissue with small interfering RNA.
Ji, J., Wernly, M., Mielgo, A., Buechner, S. A., & Erb., P. (2005). Fas-ligand gene silencing in basal cell carcinoma tissue with small interfering RNA.. Gene Therapy.