Photo of Prof Pat Eyers

Prof Pat Eyers BSc/PhD

Professor of Cell Signalling Biochemistry

    Research

    Cell Signalling, Protein phosphorylation, sulfation and chemical biology
    Tribbles pseudokinases come of age
    Tribbles pseudokinases come of age

    • Chemical Biology, protein kinase regulation, kinase and sulfotransferase inhibitors: resistance and escape mechanisms in human cancer cells and identification of new and ‘re-purpoused’ small molecule inhibitors to target unstudied and ‘drug-resistant' kinases
    • Liverpool Enzyme Screening and Assay Facility; Academic Lead and Director: screening of protein kinases and small molecule modulators using microfluidic-based technology. In collaboration with academia and pharmaceutical companies
    • Molecular analysis of human protein pseudokinases and members of the 'dark' kinome, which contains many new drug targets. Employing chemical genetics to uncover the effects of small molecules on (pseudo)kinase function in vitro and in vivo
    • Protein Kinase Biophysics: NMR, Ion Mobility and cryo-EM analysis of differentially activated and drug-resistant Mps1, Aurora A and pseudokinase proteins in complex with regulators and ligands. Design of new reporter assays to measure ligand occupancy
    • Transcriptional Kinome-wide analysis of cellular signalling networks in human cancer cells. In particular, kinome 'rewiring' in response to clinical compounds

    Protein and glycan sulfation
    Back-to-back papers analysing sulfation mechanisms
    Back-to-back papers analysing sulfation mechanisms

    We are investigating how sulfation-dependent signalling occurs in vertebrate cells, and how this controls a number of key intracellular and extracellular signalling events.

    Research Grants

    Non-canonical protein phosphorylation in human cancer cells

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

    June 2018 - January 2021

    Studentship for Emma Fairweather

    ASTRAZENECA LIMITED (UK)

    October 2017 - March 2021

    Understanding the complexity of post-translation modifications by enhancing UK capability for top-down proteomics

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC), KEELE UNIVERSITY (UK), UNIVERSITY OF LEEDS (UK)

    June 2017 - June 2018

    3-O-sulfated heparan sulfate translocation in altered membrane biology: A new strategy for early population screening and halting Alzheimer’s neurodegeneration (ArrestAD)

    EUROPEAN COMMISSION

    January 2017 - December 2020

    Therapeutic relevance of crosstalk in the Aurora A and PLK4 signalling modules

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

    October 2017 - September 2020

    Increasing Industry Engagement and Open Innovation in Health and Life Sciences - Proximity to Discovery Award

    MEDICAL RESEARCH COUNCIL (MRC)

    March 2016 - August 2017

    New tools and resources to evaluate biological sulphation

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    October 2016 - March 2018

    A streamlined approach for the analysis of drug-resistant protein kinase alleles

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

    January 2016 - December 2017

    Investigating in vivo resistance mechanisms to MEK inhibitors in uveal melanoma to enable novel combinatorial therapies.

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

    March 2016 - May 2019

    Role of serine protease activity in the pathogenesis of muscular dystrophy

    MUSCULAR DYSTROPHY ASSOCIATION USA)

    September 2015 - January 2019

    Application of advanced MS instrumentation to protein ligand binding and PTM characterisation

    BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL (BBSRC)

    January 2015 - January 2016

    Kinome-wide analysis of KRASand MYC driven cancer cell models exposed to clinical kinase and bromodomain inhibitors

    NORTH WEST CANCER RESEARCH INCORPORATING CLATTERBRIDGE CANCER RESEARCH (UK)

    September 2014 - August 2017