Photo of Prof Pat Eyers

Prof Pat Eyers BSc/PhD

Professor of Cell Signalling Biochemistry

    About

    Personal Statement

    Pat is Professor of Cell Signalling in the Department of Biochemistry, Institute of Integrative Biology at the University of Liverpool, where he runs a multidisciplinary lab. He obtained an undergraduate degree in Biochemistry at the University of Bristol, and completed his PhD with Sir Philip Cohen at the University of Dundee. After 4 years of postdoctoral research in the USA with Jim Maller, he set up his laboratory in the UK with an MRC Career Development Fellowship in 2005. His interests include all aspects of protein phosphorylation and sulfation, analysis of protein kinase and sulfotransferase regulation, pseudokinases and pseudoenzymes and kinome-wide mechanisms of acquired drug resistance in cells. He teaches medical biochemistry and cell signalling, running modules explaining the biochemical mechanisms underpinning cell communication.

    A 20 year timeline of research highlights:

    1) New paradigms for redox regulation of human protein kinases (2018-)
    2) Targeting pseudokinases with clinically-approved drugs in cancer cells (2018-)
    3) Analysis of sulfotransferases: sulfoproteomics and regulation of sulfation by small molecules (2017-)
    4) Kinome-wide responses to drugs in human breast, lung and uveal cancer models (2017-)
    5) Drug-resistant Aurora, Polo-like and Mps1 kinases for compound target-validation (2010/11/17)

    6) Conserved rate-limiting roles for PKA, PLK4 and TPX2 in the cell cycle (2005/2008/2017/2018)
    7) Purification and characterisation of TPX2, a physiological activator of Aurora A (2003)
    8) Cellular ‘target-validation’ of p38 MAPK inhibitors using chemical genetics (2000)
    9) First description of paradoxical activation of RAF kinases by chemical RAF inhibitors (1999)
    10) Co-discovery of the 'gatekeeper' residue in Ser/Thr kinases (1998)




    Awards or Honours

    • Pseudoenzymes 2016: from signalling mechanisms to disease (Biochemical Society Focussed Meeting, 2016)
    • Liverpool Enzyme Assay and Screening Facility (Department of Biochemistry, University of Liverpool, 2015)

    Funded Fellowships

    • MRC Career Development Fellowship (Medical Research Council (MRC), 2006)

    Other Personal Distinctions

    • BBSRC Pool of Experts Panel D (BBSRC, 2017)