Photo of Dr Jill Madine

Dr Jill Madine PhD

Research Fellow/Lecturer Biochemistry & Systems Biology

    Publications

    Selected Publications

    1. Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid (Journal article - 2015)
    2. Site-Specific Identification of an A ss Fibril-Heparin Interaction Site by Using Solid-State NMR Spectroscopy (Journal article - 2012)
    3. Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin (Journal article - 2010)
    4. Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR (Journal article - 2008)
    5. Cross-beta Spine Architecture of Fibrils Formed by the Amyloidogenic Segment NFGSVQFV of Medin from Solid-State NMR and X-ray Fiber Diffraction Measurements (Journal article - 2009)

    2020

    Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation (Journal article)

    Torpey, J. H., Meade, R. M., Mistry, R., Mason, J. M., & Madine, J. (2020). Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation. FRONTIERS IN NEUROSCIENCE, 14. doi:10.3389/fnins.2020.561462

    DOI: 10.3389/fnins.2020.561462

    Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice. (Journal article)

    Degenhardt, K., Wagner, J., Skodras, A., Candlish, M., Koppelmann, A. J., Wild, K., . . . Neher, J. J. (2020). Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice.. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.2011133117

    DOI: 10.1073/pnas.2011133117

    Cerebrovascular medin is associated with Alzheimer's disease and vascular dementia. (Journal article)

    Migrino, R. Q., Karamanova, N., Truran, S., Serrano, G. E., Davies, H. A., Madine, J., & Beach, T. G. (2020). Cerebrovascular medin is associated with Alzheimer's disease and vascular dementia.. Alzheimer's and Dementia, 12(1), e12072. doi:10.1002/dad2.12072

    DOI: 10.1002/dad2.12072

    Cyclophilin D binds to the acidic C-terminus region of alpha-Synuclein and affects its aggregation characteristics (Journal article)

    Torpey, J., Madine, J., Wood, A., & Lian, L. -Y. (2020). Cyclophilin D binds to the acidic C-terminus region of alpha-Synuclein and affects its aggregation characteristics. SCIENTIFIC REPORTS, 10(1). doi:10.1038/s41598-020-66200-9

    DOI: 10.1038/s41598-020-66200-9

    Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction (Journal article)

    Younger, S., Jang, H., Davies, H. A., Niemiec, M. J., Garcia, J. G. N., Nussinov, R., . . . Arce, F. T. (2020). Medin Oligomer Membrane Pore Formation: A Potential Mechanism of Vascular Dysfunction. BIOPHYSICAL JOURNAL, 118(11), 2769-2782. doi:10.1016/j.bpj.2020.04.026

    DOI: 10.1016/j.bpj.2020.04.026

    Endothelial Immune Activation by Medin: Potential Role in Cerebrovascular Disease and Reversal by Monosialoganglioside-Containing Nanoliposomes (Journal article)

    Karamanova, N., Truran, S., Serrano, G. E., Beach, T. G., Madine, J., Weissig, V., . . . Migrino, R. Q. (2020). Endothelial Immune Activation by Medin: Potential Role in Cerebrovascular Disease and Reversal by Monosialoganglioside-Containing Nanoliposomes. Journal of the American Heart Association, 9(2). doi:10.1161/JAHA.119.014810

    DOI: 10.1161/JAHA.119.014810

    2019

    Biochemical Characteristics of the Aortic True Lumen Wall, False Lumen Wall and Flap During the Acute Phases of Type A Aortic Dissection in Humans (Conference Paper)

    Harky, A., Chim, Y. H., Davies, H. A., Field, M., Nawaytou, O., Akhtar, R., & Madine, J. (2019). Biochemical Characteristics of the Aortic True Lumen Wall, False Lumen Wall and Flap During the Acute Phases of Type A Aortic Dissection in Humans. In CIRCULATION Vol. 140. Retrieved from http://gateway.webofknowledge.com/

    Bicuspid valve aortopathy is associated with distinct patterns of matrix degradation (Journal article)

    Chim, Y. H., Davies, H., Mason, D., Nawaytou, O., Field, M., Madine, J., & Akhtar, R. (2019). Bicuspid valve aortopathy is associated with distinct patterns of matrix degradation. The Journal of Thoracic and Cardiovascular Surgery, 160(6), E239-E257. doi:10.1016/j.jtcvs.2019.08.094

    DOI: 10.1016/j.jtcvs.2019.08.094

    Idiopathic degenerative thoracic aneurysms are associated with increased aortic medial amyloid (Journal article)

    Davies, H. A., Caamano-Gutierrez, E., Chim, Y. H., Field, M., Nawaytou, O., Ressel, L., . . . Madine, J. (n.d.). Idiopathic degenerative thoracic aneurysms are associated with increased aortic medial amyloid. Amyloid: international journal of experimental and clinical investigation, 26(3), 148-155. doi:10.1080/13506129.2019.1625323

    DOI: 10.1080/13506129.2019.1625323

    Macro- and Micro-mechanical Properties of the Ovine Aorta: Correlation with Regional Variations in Collagen, Elastin and Glycosominoglycan Levels (Journal article)

    Panpho, P., Brendan, G., Chim, Y. H., Davies, H., Field, M., Madine, J., & Akhtar, R. (n.d.). Macro- and Micro-mechanical Properties of the Ovine Aorta: Correlation with Regional Variations in Collagen, Elastin and Glycosominoglycan Levels. Artery Research, 25(1-2), 27-36. doi:10.2991/artres.k.191114.003

    DOI: 10.2991/artres.k.191114.003

    Quality of Reporting in Human Aortic Tissue Research – A Systematic Review (Journal article)

    Chim, Y. -H., Caamaño-Gutiérrez, E., Birla, R., Madine, J., Field, M., Akhtar, R., & Davies, H. A. (n.d.). Quality of Reporting in Human Aortic Tissue Research – A Systematic Review. Artery Research. doi:10.2991/artres.k.191106.003

    DOI: 10.2991/artres.k.191106.003

    BAV AORTOPATHY EXHIBITS A UNIQUE PATTERN OF AORTIC DEGRADATION EVEN THOUGH THE CLINICAL RISK OF RUPTURE MIRRORS OTHER ANEURYSMS - A MICROMECHANICAL AND MICROSTRUCTURAL APPROACH (Conference Paper)

    Chim, Y. H., Davies, H., Field, M., Madine, J., & Akhtar, R. (2019). BAV AORTOPATHY EXHIBITS A UNIQUE PATTERN OF AORTIC DEGRADATION EVEN THOUGH THE CLINICAL RISK OF RUPTURE MIRRORS OTHER ANEURYSMS - A MICROMECHANICAL AND MICROSTRUCTURAL APPROACH. In HEART Vol. 105 (pp. A162). doi:10.1136/heartjnl-2019-BCS.196

    DOI: 10.1136/heartjnl-2019-BCS.196

    Cofactor-mediated amyloidogenesis (Journal article)

    Madine, J. (2019). Cofactor-mediated amyloidogenesis. BIOSCIENCE REPORTS, 39. doi:10.1042/BSR20190327

    DOI: 10.1042/BSR20190327

    Discerning How Vascular Inflammation Modulates Neuroinflammation Using Novel Vascular Brain Organ-On-A-Chip: Proof-of-Concept Study. (Conference Paper)

    Veldhuizen, J., Truran, S., Madine, J., Davies, H., Karamanova, N., Nikkhah, M., & Migrino, R. Q. (2019). Discerning How Vascular Inflammation Modulates Neuroinflammation Using Novel Vascular Brain Organ-On-A-Chip: Proof-of-Concept Study.. In STROKE Vol. 50. Retrieved from http://gateway.webofknowledge.com/

    Endothelial Cell Proinflammatory Priming by Amyloidogenic Medin via NF[kappa]B and Inflammasome Pathways and Reversal by Monosialoganglioside Nanoliposomes (Conference Paper)

    Karamanova, N., Truran, S., Madine, J., Davies, H., Zhang, W., Franco, D., . . . Migrino, R. Q. (2019). Endothelial Cell Proinflammatory Priming by Amyloidogenic Medin via NF[kappa]B and Inflammasome Pathways and Reversal by Monosialoganglioside Nanoliposomes. In STROKE Vol. 50. Retrieved from http://gateway.webofknowledge.com/

    Elastic, Viscoelastic and Dissection Resistance Properties of the Ovine Aorta: Correlation with Regional Variations in Collagen, Elastin and Glycosominoglycan Levels (Journal article)

    Panpho, P., Al-Matari, M., Field, M., Madine, J., & Akhtar, R. (2019). Elastic, Viscoelastic and Dissection Resistance Properties of the Ovine Aorta: Correlation with Regional Variations in Collagen, Elastin and Glycosominoglycan Levels.

    2018

    Isolation and purification of recombinant immunoglobulin light chain variable domains from the periplasmic space of Escherichia coli (Journal article)

    Hand, K., Wilkinson, M., & Madine, J. (2018). Isolation and purification of recombinant immunoglobulin light chain variable domains from the periplasmic space of Escherichia coli. PLoS One, 13(10). doi:10.1371/journal.pone.0206167

    DOI: 10.1371/journal.pone.0206167

    Peripheral Adipose Arteriole Dilator Response to Amyloid Proteins and Palmitic Acid Recapitulates Central Leptomeningeal Arteriole Response: Validation of a Novel Human Tissue Model (Conference Paper)

    Truran, S., Karamanova, N., Serrano, G., Madine, J., Davies, H., Beach, T., & Migrino, R. Q. (2018). Peripheral Adipose Arteriole Dilator Response to Amyloid Proteins and Palmitic Acid Recapitulates Central Leptomeningeal Arteriole Response: Validation of a Novel Human Tissue Model. In FASEB JOURNAL Vol. 32. Retrieved from http://gateway.webofknowledge.com/

    Human cerebral collateral arteriole function in subjects with normal cognition, mild cognitive impairment, and dementia (Journal article)

    Migrino, R. Q., Truran, S., Karamanova, N., Davies, H., Madine, J., Reaven, P., & Beach, T. G. (2018). Human cerebral collateral arteriole function in subjects with normal cognition, mild cognitive impairment, and dementia. American Journal of Physiology: Heart and Circulatory Physiology, 315(2), H284-H290. doi:10.1152/ajpheart.00206.2018

    DOI: 10.1152/ajpheart.00206.2018

    Insights into the Origin of Distinct Medin Fibril Morphologies Induced by Incubation Conditions and Seeding (Journal article)

    Davies, H., Lee, C. F., Miller, L., Liu, L., & Madine, J. (2018). Insights into the Origin of Distinct Medin FibrilMorphologies Induced by Incubation Conditionsand Seeding. International Journal of Molecular Sciences, 19(5), 1-15. doi:10.3390/ijms19051357

    DOI: 10.3390/ijms19051357

    Amyloidogenic Medin Impairs Endothelial Cell Autophagy and Viability that is Reversed by Monosialoganglioside Nanoliposomes (Conference Paper)

    Karamanova, N., Truran, S., Weissig, V., Madine, J., Davies, H., Guzman-Villanueva, D., & Migrino, R. (2018). Amyloidogenic Medin Impairs Endothelial Cell Autophagy and Viability that is Reversed by Monosialoganglioside Nanoliposomes. In FASEB JOURNAL Vol. 32. Retrieved from http://gateway.webofknowledge.com/

    Monitoring Native and Aggregate Structure of Amino Acids and Human Insulin with Blue Autofluorescence (Conference Paper)

    Cumberbatch, N., Madine, J., & Arnolds, H. (2018). Monitoring Native and Aggregate Structure of Amino Acids and Human Insulin with Blue Autofluorescence. In BIOPHYSICAL JOURNAL Vol. 114 (pp. 172A). doi:10.1016/j.bpj.2017.11.959

    Comparison of Ex-vivo Human Leptomeningeal Arteriole Function in Cognitively Normal and Dementia Disorders From Rapid Autopsy Brain Donors (Conference Paper)

    Madrigal, C., Truran, S., Karamanova, N., Serrano, G., Madine, J., Davies, H., . . . Migrino, R. Q. (2018). Comparison of Ex-vivo Human Leptomeningeal Arteriole Function in Cognitively Normal and Dementia Disorders From Rapid Autopsy Brain Donors. In STROKE Vol. 49. Retrieved from http://gateway.webofknowledge.com/

    2017

    Medin Amyloid Protein-Induced Human Leptomeningeal Arteriole Endothelial Dysfunction and Pro-Inflammatory Signaling are Reversed by Monosialoganglioside Nanoliposomes (Conference Paper)

    Truran, S., Karamanova, N., Madine, J., Davies, H., Guzman-Villanueva, D., Serrano, G., . . . Migrino, R. Q. (2017). Medin Amyloid Protein-Induced Human Leptomeningeal Arteriole Endothelial Dysfunction and Pro-Inflammatory Signaling are Reversed by Monosialoganglioside Nanoliposomes. In CIRCULATION Vol. 136. Retrieved from http://gateway.webofknowledge.com/

    Medin Amyloid, but Not beta-amyloid, Induces Pro-Inflammatory Signaling in Endothelial Cells That is Synergistic With Palmitic Acid (Conference Paper)

    Karamanova, N., Truran, S., Madine, J., Davies, H., Anderson, J., Franco, D. A., . . . Migrino, R. Q. (2017). Medin Amyloid, but Not beta-amyloid, Induces Pro-Inflammatory Signaling in Endothelial Cells That is Synergistic With Palmitic Acid. In CIRCULATION Vol. 136. Retrieved from http://gateway.webofknowledge.com/

    Using an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein (Journal article)

    Phelan, M. M., Caamaño-Gutiérrez, E., Gant, M. S., Grosman, R. X., & Madine, J. (2017). Using an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein. Metabolomics, 13(12). doi:10.1007/s11306-017-1289-5

    DOI: 10.1007/s11306-017-1289-5

    Effect of amino acid mutations on the conformational dynamics of amyloidogenic immunoglobulin light-chains: A combined NMR and in silico study (Journal article)

    Mukherjee, S., Pondaven, S. P., Hand, K., Madine, J., & Jaroniec, C. P. (2017). Effect of amino acid mutations on the conformational dynamics of amyloidogenic immunoglobulin light-chains: A combined NMR and in silico study. Scientific Reports, 7. doi:10.1038/s41598-017-10906-w

    DOI: 10.1038/s41598-017-10906-w

    Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation through the Receptor for Advanced Glycation Endproducts (Journal article)

    Migrino, M., Davies, H. A., Truran, S., Karamanova, N., Franco, D. A., Beach, T. G., . . . Madine, J. (2017). Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation through the Receptor for Advanced Glycation Endproducts. Cardiovascular Research, 113(11), 1389-1402. doi:10.1093/cvr/cvx135

    DOI: 10.1093/cvr/cvx135

    Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation Through the Receptor for Advanced Glycation Endproducts (Conference Paper)

    Migrino, R. Q., Davies, H., Truran, S., Karamanova, N., Franco, D. A., Serrano, G., . . . Madine, J. (2017). Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation Through the Receptor for Advanced Glycation Endproducts. In FASEB JOURNAL Vol. 31. Retrieved from http://gateway.webofknowledge.com/

    Probing Medin Monomer Structure and its Amyloid Nucleation Using 13C-Direct Detection NMR in Combination with Structural Bioinformatics (Journal article)

    Davies, H. A., Rigden, D. J., Phelan, M. M., & Madine, J. (2017). Probing Medin Monomer Structure and its Amyloid Nucleation Using 13C-Direct Detection NMR in Combination with Structural Bioinformatics. Scientific Reports, 7. doi:10.1038/srep45224

    DOI: 10.1038/srep45224

    Heparin and methionine oxidation promote the formation of apolipoprotein A-I amyloid comprising a-helical and ß-sheet structures. (Journal article)

    Townsend, D., Hughes, E., Hussain, R., Siligardi, G., Baldock, S. J., Madine, J., & Middleton, D. A. (2017). Heparin and methionine oxidation promote the formation of apolipoprotein A-I amyloid comprising a-helical and ß-sheet structures.. Biochemistry, 56(11), 1632-1644. doi:10.1021/acs.biochem.6b01120

    DOI: 10.1021/acs.biochem.6b01120

    2016

    HUMAN MICROVASCULAR ENDOTHELIAL DYSFUNCTION INDUCED BY AMYLOIDOGENIC MEDIN PROTEIN (Conference Paper)

    Migrino, R. Q., Truran, S., Karamanova, N., Franco, D., Davies, H. A., Burciu, C., & Madine, J. (2016). HUMAN MICROVASCULAR ENDOTHELIAL DYSFUNCTION INDUCED BY AMYLOIDOGENIC MEDIN PROTEIN. In JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Vol. 67 (pp. 2310). doi:10.1016/S0735-1097(16)32311-7

    H-1, N-15 and C-13 assignment of the amyloidogenic protein medin using fast-pulsing NMR techniques (Journal article)

    Davies, H. A., Phelan, M. M., & Madine, J. (2016). H-1, N-15 and C-13 assignment of the amyloidogenic protein medin using fast-pulsing NMR techniques. BIOMOLECULAR NMR ASSIGNMENTS, 10(1), 75-77. doi:10.1007/s12104-015-9641-z

    DOI: 10.1007/s12104-015-9641-z

    Nanoliposomes protect against human arteriole endothelial dysfunction induced by beta-amyloid peptide (Journal article)

    Truran, S., Weissig, V., Madine, J., Davies, H. A., Guzman-Villanueva, D., Franco, D. A., . . . Migrino, R. Q. (2016). Nanoliposomes protect against human arteriole endothelial dysfunction induced by beta-amyloid peptide. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 36(2), 405-412. doi:10.1177/0271678X15610134

    DOI: 10.1177/0271678X15610134

    2015

    Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid (Journal article)

    Davies, H., Phelan, M., Wilkinson, M., Migrino, R., Truran, S., Franco, D. A., . . . Madine, J. (2015). Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid. Biophysical Journal, 109(11), 2363-2370. doi:10.1016/j.bpj.2015.10.034

    DOI: 10.1016/j.bpj.2015.10.034

    beta-amyloid Peptide-Induced Human Arteriole Endothelial Dysfunction is Attenuated by Nanoliposomes (Conference Paper)

    Guzman-Villanueva, D., Madine, J., Truran, S., Davies, H., Burciu, C., Franco, D., . . . Migrino, R. (2015). beta-amyloid Peptide-Induced Human Arteriole Endothelial Dysfunction is Attenuated by Nanoliposomes. In FASEB JOURNAL Vol. 29. Retrieved from http://gateway.webofknowledge.com/

    Comparison with amyloid-beta reveal an aspartate residue that stabilizes fibrils of the aortic amyloid polypeptide medin (Journal article)

    Davies, H., Madine, J., & Middleton, D. (2015). Comparison with amyloid-beta reveal an aspartate residue that stabilizes fibrils of the aortic amyloid polypeptide medin. The Journal of Biological Chemistry, 290, 7791-7803. doi:10.1074/jbc.M114.602177

    DOI: 10.1074/jbc.M114.602177

    2013

    Heparin Promotes the Rapid Fibrillization of a Peptide with Low Intrinsic Amyloidogenicity (Journal article)

    Madine, J., Davies, H. A., Hughes, E., & Middleton, D. A. (2013). Heparin Promotes the Rapid Fibrillization of a Peptide with Low Intrinsic Amyloidogenicity. BIOCHEMISTRY, 52(50), 8984-8992. doi:10.1021/bi401231u

    DOI: 10.1021/bi401231u

    Insights into the Molecular Architecture of a Peptide Nanotube Using FTIR and Solid-State NMR Spectroscopic Measurements on an Aligned Sample (Journal article)

    Middleton, D. A., Madine, J., Castelletto, V., & Hamley, I. W. (2013). Insights into the Molecular Architecture of a Peptide Nanotube Using FTIR and Solid-State NMR Spectroscopic Measurements on an Aligned Sample. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(40), 10537-10540. doi:10.1002/anie.201301960

    DOI: 10.1002/anie.201301960

    2012

    Site-Specific Identification of an A ss Fibril-Heparin Interaction Site by Using Solid-State NMR Spectroscopy (Journal article)

    Madine, J., Pandya, M. J., Hicks, M. R., Rodger, A., Yates, E. A., Radford, S. E., & Middleton, D. A. (2012). Site-Specific Identification of an A ss Fibril-Heparin Interaction Site by Using Solid-State NMR Spectroscopy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(52), 13140-13143. doi:10.1002/anie.201204459

    DOI: 10.1002/anie.201204459

    Insights into the aggregation pathway of a-synuclein (Chapter)

    Madine, J. (2012). Insights into the aggregation pathway of a-synuclein. In Amyloids: Composition, Functions and Pathology (pp. 149-162).

    Fibrils and nanotubes assembled from a modified amyloid-beta peptide fragment differ in the packing of the same beta-sheet building blocks (Journal article)

    Madine, J., Davies, H. A., Shaw, C., Hamley, I. W., & Middleton, D. A. (2012). Fibrils and nanotubes assembled from a modified amyloid-beta peptide fragment differ in the packing of the same beta-sheet building blocks. CHEMICAL COMMUNICATIONS, 48(24), 2976-2978. doi:10.1039/c2cc17118j

    DOI: 10.1039/c2cc17118j

    Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin (Journal article)

    Davies, H. A., Madine, J., & Middleton, D. A. (2012). Solid-state NMR reveals differences in the packing arrangements of peptide aggregates derived from the aortic amyloid polypeptide medin. JOURNAL OF PEPTIDE SCIENCE, 18(1), 65-72. doi:10.1002/psc.1418

    DOI: 10.1002/psc.1418

    2011

    Insights into the aggregation pathway of a-synuclein (Chapter)

    Madine, J. (2011). Insights into the aggregation pathway of a-synuclein. In Amyloids: Composition, Functions and Pathology (pp. in press). New York: Nova Science Publishers.

    2010

    Measurement of multiple torsional angles from one-dimensional solid-state NMR spectra: application to the conformational analysis of a ligand in its biological receptor site (Journal article)

    Edwards, R., Madine, J., Fielding, L., & Middleton, D. A. (2010). Measurement of multiple torsional angles from one-dimensional solid-state NMR spectra: application to the conformational analysis of a ligand in its biological receptor site. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 12(42), 13999-14008. doi:10.1039/c0cp00326c

    DOI: 10.1039/c0cp00326c

    Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin (Journal article)

    Madine, J., & Middleton, D. A. (2010). Comparison of aggregation enhancement and inhibition as strategies for reducing the cytotoxicity of the aortic amyloid polypeptide medin. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 39(9), 1281-1288. doi:10.1007/s00249-010-0581-3

    DOI: 10.1007/s00249-010-0581-3

    2009

    Evaluation of beta-Alanine- and GABA-Substituted Peptides as Inhibitors of Disease-Linked Protein Aggregation (Journal article)

    Madine, J., Wang, X., Brown, D. R., & Middleton, D. A. (2009). Evaluation of beta-Alanine- and GABA-Substituted Peptides as Inhibitors of Disease-Linked Protein Aggregation. CHEMBIOCHEM, 10(12), 1982-1987. doi:10.1002/cbic.200900219

    DOI: 10.1002/cbic.200900219

    Inhibitors of protein aggregation and toxicity (Journal article)

    Amijee, H., Madine, J., Middleton, D. A., & Doig, A. J. (2009). Inhibitors of protein aggregation and toxicity. BIOCHEMICAL SOCIETY TRANSACTIONS, 37, 692-696. doi:10.1042/BST0370692

    DOI: 10.1042/BST0370692

    TARGETING alpha-SYNUCLEIN AGGREGATION FOR PARKINSON'S DISEASE TREATMENT (Journal article)

    Madine, J., & Middleton, D. A. (2009). TARGETING alpha-SYNUCLEIN AGGREGATION FOR PARKINSON'S DISEASE TREATMENT. DRUGS OF THE FUTURE, 34(8), 655-663. doi:10.1358/dof.2009.034.08.1391472

    DOI: 10.1358/dof.2009.034.08.1391472

    Exploiting a C-13-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils (Journal article)

    Madine, J., Clayton, J. C., Yates, E. A., & Middleton, D. A. (2009). Exploiting a C-13-labelled heparin analogue for in situ solid-state NMR investigations of peptide-glycan interactions within amyloid fibrils. ORGANIC & BIOMOLECULAR CHEMISTRY, 7(11), 2414-2420. doi:10.1039/b820808e

    DOI: 10.1039/b820808e

    Cross-beta Spine Architecture of Fibrils Formed by the Amyloidogenic Segment NFGSVQFV of Medin from Solid-State NMR and X-ray Fiber Diffraction Measurements (Journal article)

    Madine, J., Copland, A., Serpell, L. C., & Middleton, D. A. (2009). Cross-beta Spine Architecture of Fibrils Formed by the Amyloidogenic Segment NFGSVQFV of Medin from Solid-State NMR and X-ray Fiber Diffraction Measurements. BIOCHEMISTRY, 48(14), 3089-3099. doi:10.1021/bi802164e

    DOI: 10.1021/bi802164e

    Targeting alpha-synuclein aggregation for Parkinson's disease treatement (Journal article)

    Madine, J., & Middleton, D. A. (2009). Targeting alpha-synuclein aggregation for Parkinson's disease treatement. Drugs of the Future, 34(8), 655. doi:10.1358/dof.2009.034.08.1391472

    DOI: 10.1358/dof.2009.034.08.1391472

    2008

    Structural Insights into the Polymorphism of Amyloid-Like Fibrils Formed by Region 20-29 of Amylin Revealed by Solid-State NMR and X-ray Fiber Diffraction (Journal article)

    Madine, J., Jack, E., Stockley, P. G., Radford, S. E., Serpell, L. C., & Middleton, D. A. (2008). Structural Insights into the Polymorphism of Amyloid-Like Fibrils Formed by Region 20-29 of Amylin Revealed by Solid-State NMR and X-ray Fiber Diffraction. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(45), 14990-15001. doi:10.1021/ja802483d

    DOI: 10.1021/ja802483d

    The effects of -synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy (Journal article)

    Madine, J., Hughes, E., Doig, A. J., & Middleton, D. A. (2008). The effects of -synuclein on phospholipid vesicle integrity: a study using 31P NMR and electron microscopy. MOLECULAR MEMBRANE BIOLOGY, 25(6-7), 518-527. doi:10.1080/09687680802467977

    DOI: 10.1080/09687680802467977

    Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR (Journal article)

    Madine, J., Doig, A. J., & Middleton, D. A. (2008). Design of an N-methylated peptide inhibitor of alpha-synuclein aggregation guided by solid-state NMR. J. Am. Chem. Soc., 130(7873-7).

    Membrane interactions of peptides representing the polybasic regions of three Rho GTPases are sensitive to the distribution of arginine and lysine residues (Journal article)

    Jack, E. R., Madine, J., Lian, L. -Y., & Middleton, D. A. (2008). Membrane interactions of peptides representing the polybasic regions of three Rho GTPases are sensitive to the distribution of arginine and lysine residues. MOLECULAR MEMBRANE BIOLOGY, 25(1), 14-22. doi:10.1080/09687680701494007

    DOI: 10.1080/09687680701494007

    2006

    An NMR strategy for obtaining multiple conformational constraints for N-15-C-13 spin-pair labelled organic solids (Journal article)

    Madine, J., & Middleton, D. A. (2006). An NMR strategy for obtaining multiple conformational constraints for N-15-C-13 spin-pair labelled organic solids. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 8(44), 5223-5228. doi:10.1039/b610014g

    DOI: 10.1039/b610014g

    A study of the regional effects of alpha-synuclein on the organization and stability of phospholipid bilayers (Journal article)

    Madine, J., Doig, A. J., & Middleton, D. A. (2006). A study of the regional effects of alpha-synuclein on the organization and stability of phospholipid bilayers. BIOCHEMISTRY, 45(18), 5783-5792. doi:10.1021/bi052151q

    DOI: 10.1021/bi052151q

    2005

    Studies of the aggregation of an amyloidogenic alpha-synuclein peptide fragment (Journal article)

    Madine, J., Doig, A. J., Kitmitto, A., & Middleton, D. A. (2005). Studies of the aggregation of an amyloidogenic alpha-synuclein peptide fragment. BIOCHEMICAL SOCIETY TRANSACTIONS, 33, 1113-1115. doi:10.1042/BST0331113

    DOI: 10.1042/BST0331113

    Studies of the aggregation of an amyloidogenic alpha-synuclein peptide fragment. (Journal article)

    Madine, J., Doig, A. J., Kitmitto, A., & Middleton, D. A. (2005). Studies of the aggregation of an amyloidogenic alpha-synuclein peptide fragment.. Biochemical Society transactions, 33(Pt 5), 1113-1115. doi:10.1042/bst20051113

    DOI: 10.1042/bst20051113

    2004

    The aggregation and membrane-binding properties of an alpha-synuclein peptide fragment (Journal article)

    Madine, J., Doig, A. J., & Middleton, D. A. (2004). The aggregation and membrane-binding properties of an alpha-synuclein peptide fragment. BIOCHEMICAL SOCIETY TRANSACTIONS, 32, 1127-1129. doi:10.1042/BST0321127

    DOI: 10.1042/BST0321127

    Screening molecular associations with lipid membranes using natural abundance 13C cross-polarization magic-angle spinning NMR and principal component analysis. (Journal article)

    Middleton, D. A., Hughes, E., & Madine, J. (2004). Screening molecular associations with lipid membranes using natural abundance 13C cross-polarization magic-angle spinning NMR and principal component analysis.. Journal of the American Chemical Society, 126(31), 9478-9479. doi:10.1021/ja048226f

    DOI: 10.1021/ja048226f

    Screening molecular associations with lipid membranes using natural abundance C-13 cross-polarization magic-angle spinning NMR and principal component analysis (Journal article)

    Middleton, D. A., Hughes, E., & Madine, J. (2004). Screening molecular associations with lipid membranes using natural abundance C-13 cross-polarization magic-angle spinning NMR and principal component analysis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 126(31), 9478-9479. doi:10.1021/ja048226f

    DOI: 10.1021/ja048226f