Research outputs
2026
Mucoadhesive nanofibers for ocular drug delivery: mechanisms, design strategies, and applications
Desai, N., Colley, H. E., Krishna, Y., Bosworth, L. A., & Kearns, V. R. (2026). Mucoadhesive nanofibers for ocular drug delivery: mechanisms, design strategies, and applications. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 16(4), 1096-1135. doi:10.1007/s13346-025-01894-w
Conjunctival Squamous Cell Carcinoma: A Clinical Review of Diagnostic Features, Genetics, Current Management and an Update on Targeted and Immunotherapies
Mir, M., Mudhar, H. S., Sagoo, M. S., Gichuhi, S., & Krishna, Y. (2026). Conjunctival Squamous Cell Carcinoma: A Clinical Review of Diagnostic Features, Genetics, Current Management and an Update on Targeted and Immunotherapies. Cancers, 18(6), 940. doi:10.3390/cancers18060940
Conjunctival Squamous Cell Carcinoma: A Clinical Review of Diagnostic Features, Genetics, Current Management and an Update on Targeted and Immunotherapies
2025
OP-4 Early intervention may reduce ultrastructural changes in descemet’s membrane in fuchs endothelial corneal dystrophy
Airaldi, M., Krishna, Y., Chen, X., Levis, H., Thaung, C., Zheng, Y., . . . Kaye, S. (2025). OP-4 Early intervention may reduce ultrastructural changes in descemet’s membrane in fuchs endothelial corneal dystrophy. In Proceedings of the Bowman Club Meeting 2025 (pp. A2.1-A2). BMJ Publishing Group Ltd. doi:10.1136/bmjoo-2025-bca.4
International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus.
Short, E., Huckstepp, R. T. R., Alavian, K., Amoaku, W. M. K., Barber, T. M., van Beek, E. J. R., . . . Bentley, B. L. (2025). International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus.. GeroScience. doi:10.1007/s11357-025-01509-9
Follicular Lymphoma Detected in a Patient Undergoing Mohs Surgery: A Case Report.
Defty, C., Krishna, Y., Khan, M. A. A., Sharma, N., & Tehrani, H. (2025). Follicular Lymphoma Detected in a Patient Undergoing Mohs Surgery: A Case Report.. Cureus, 17(1), e77583. doi:10.7759/cureus.77583
Orbital Kimura disease: maintenance therapy using mycophenolate mofetil
Fenech, M., Ajanaku, A., McCormick, A., Coupland, S. E., Krishna, Y., Sultan, Z., & Ghadiri, N. (2025). Orbital Kimura disease: maintenance therapy using mycophenolate mofetil. ORBIT-THE INTERNATIONAL JOURNAL ON ORBITAL DISORDERS-OCULOPLASTIC AND LACRIMAL SURGERY, 44(2), 215-222. doi:10.1080/01676830.2024.2358061
2024
Conjunctival Melanoma: A Clinical Review and Update (vol 16, 3121, 2024)
Butt, K., Hussain, R., Coupland, S. E., & Krishna, Y. (2024). Conjunctival Melanoma: A Clinical Review and Update (vol 16, 3121, 2024). CANCERS, 16(22). doi:10.3390/cancers16223721
Defining an ageing-related pathology, disease or syndrome: International Consensus Statement.
Short, E., ICCARP., Calimport, S., & Bentley, B. (2024). Defining an ageing-related pathology, disease or syndrome: International Consensus Statement.. GeroScience. doi:10.1007/s11357-024-01315-9
Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement.
Conjunctival Melanoma: A Clinical Review and Update
Butt, K., Hussain, R., Coupland, S. E., & Krishna, Y. (2024). Conjunctival Melanoma: A Clinical Review and Update. CANCERS, 16(18). doi:10.3390/cancers16183121
Conjunctival Melanoma: A Clinical Review and Update
A MULTICENTRE STUDY VALIDATES THE WHO 2022 CLASSIFICATION FOR CONJUNCTIVAL MELANOCYTIC INTRAEPITHELIAL LESIONS WITH IMPROVED CLINICAL AND PROGNOSTIC INFORMATION
Krishna, Y., Mudhar, H., Mudhar, H., Cross, S., Auw-Haedrich, C., Barnhill, R., . . . Coupland, S. (2024). A MULTICENTRE STUDY VALIDATES THE WHO 2022 CLASSIFICATION FOR CONJUNCTIVAL MELANOCYTIC INTRAEPITHELIAL LESIONS WITH IMPROVED CLINICAL AND PROGNOSTIC INFORMATION. In EYE Vol. 38 (pp. 137). Retrieved from https://www.webofscience.com/
A Multicenter Study Validates the WHO 2022 Classification for Conjunctival Melanocytic Intraepithelial Lesions With Clinical and Prognostic Relevance
Mudhar, H. S., Krishna, Y., Cross, S., Auw-Haedrich, C., Barnhill, R., Cherepanoff, S., . . . Coupland, S. E. (2024). A Multicenter Study Validates the WHO 2022 Classification for Conjunctival Melanocytic Intraepithelial Lesions With Clinical and Prognostic Relevance. LABORATORY INVESTIGATION, 104(1). doi:10.1016/j.labinv.2023.100281
2023
Periocular Sebaceous Carcinoma: A Case Audit from the National Specialist Ophthalmic Pathology Service in Liverpool from 2009 to 2022 to Assess the Diagnostic Utility of PRAME Expression
Salleh, A. A., Krishna, Y., & Coupland, S. E. (2024). Periocular Sebaceous Carcinoma: A Case Audit from the National Specialist Ophthalmic Pathology Service in Liverpool from 2009 to 2022 to Assess the Diagnostic Utility of PRAME Expression. OCULAR ONCOLOGY AND PATHOLOGY, 10(1), 1-8. doi:10.1159/000535169
Tumor-associated retinal pigmentation (TARP) in choroidal melanoma
Wallace, A., Krishna, Y., Coupland, S. E., Heimann, H., Diafas, A., & Hussain, R. N. (2023). Tumor-associated retinal pigmentation (TARP) in choroidal melanoma. Ophthalmology. doi:10.1016/j.ophtha.2023.05.009
Low-Dose Propofol with Peribulbar Anaesthesia for Cataract Surgery
Ahmed, M., Krishna, Y., Popova, P., Herbert, R., Sidaras, G., Choudhary, A., & Kaye, S. B. B. (2023). Low-Dose Propofol with Peribulbar Anaesthesia for Cataract Surgery. JOURNAL OF CLINICAL MEDICINE, 12(7). doi:10.3390/jcm12072742
Ruthenium<SUP>106</SUP> plaque brachytherapy for uveal leiomyoma: a new approach to treatment?
Eibenberger, K., Hussain, R., Krishna, Y., Coupland, S. E., & Heimann, H. (2023). Ruthenium<SUP>106</SUP> plaque brachytherapy for uveal leiomyoma: a new approach to treatment?. EYE, 37(5), 1042-1044. doi:10.1038/s41433-022-02079-2
Diagnostic uncertainty following orbital injury from a grease gun
Jawad, M., Yamini, K., Sultan, Z., Coupland, S., Hsuan, J., & McCormick, A. (2021). Diagnostic uncertainty following orbital injury from a grease gun. Orbit, 1-5. doi:10.1080/01676830.2021.1992790
2022
A Retrospective Analysis of 10 Years of Liver Surveillance Undertaken in Uveal Melanoma Patients Treated at the Supraregional "Liverpool Ocular Oncology Centre", UK
Rola, A. C., Kalirai, H., Taktak, A. F. G., Eleuteri, A., Krishna, Y., Hussain, R., . . . Coupland, S. E. (2022). A Retrospective Analysis of 10 Years of Liver Surveillance Undertaken in Uveal Melanoma Patients Treated at the Supraregional "Liverpool Ocular Oncology Centre", UK. CANCERS, 14(9). doi:10.3390/cancers14092187
2020
Optic nerve head sarcoidosis mimicking an intraocular tumour, and occurring as the first manifestation of neuro-ocular sarcoidosis.
Krishna, Y., Christou, L., Khzouz, J., Hussain, R., Heimann, H., & Coupland, S. E. (2020). Optic nerve head sarcoidosis mimicking an intraocular tumour, and occurring as the first manifestation of neuro-ocular sarcoidosis.. American journal of ophthalmology case reports, 20, 100988. doi:10.1016/j.ajoc.2020.100988
Transcriptome Profiling Reveals New Insights into the Immune Microenvironment and Upregulation of Novel Biomarkers in Metastatic Uveal Melanoma
Krishna, Y., Acha-Sagredo, A., Sabat-Pospiech, D., Kipling, N., Clarke, K., Figueiredo, C. R., . . . Coupland, S. E. (2020). Transcriptome Profiling Reveals New Insights into the Immune Microenvironment and Upregulation of Novel Biomarkers in Metastatic Uveal Melanoma. CANCERS, 12(10). doi:10.3390/cancers12102832
An Unusual Case of Hyperkeratosis
Krishna, Y., White, J., Sinha, T., & Bakshi, A. (2019). An Unusual Case of Hyperkeratosis. In JOURNAL OF PATHOLOGY Vol. 249 (pp. S51). Retrieved from https://www.webofscience.com/
Optic Nerve Sarcoidosis Presenting as a 'Tumour' at the Optic Disc
Krishna, Y., Khzouz, J., Heimann, H., & Coupland, S. (2019). Optic Nerve Sarcoidosis Presenting as a 'Tumour' at the Optic Disc. In JOURNAL OF PATHOLOGY Vol. 249 (pp. S18). Retrieved from https://www.webofscience.com/
Primary sinonasal neuroendocrine carcinoma invading the orbit
Krishna, Y., McCormick, A., & Coupland, S. E. (2020). Primary sinonasal neuroendocrine carcinoma invading the orbit. Diagnostic Histopathology, 26(4), 188-191. doi:10.1016/j.mpdhp.2020.01.006
Hyperkeratosis lenticularis perstans (Flegel disease)
Krishna, Y., White, J., Sinha, T., & Bakshi, A. (2020). Hyperkeratosis lenticularis perstans (Flegel disease). Diagnostic Histopathology, 26(3), 143-146. doi:10.1016/j.mpdhp.2019.12.006
2018
Dermal chondroid syringoma
Krishna, Y., & Meara, N. (2018). Dermal chondroid syringoma. Diagnostic Histopathology, 24(5), 189-190. doi:10.1016/j.mpdhp.2018.03.003
Inflammatory cell infiltrates in metastatic uveal melanoma
Krishna, Y., McCarthy, C., Kalirai, H., & Coupland, S. (2018). Inflammatory cell infiltrates in metastatic uveal melanoma. European Journal of Surgical Oncology, 44, S6. doi:10.1016/j.ejso.2018.01.239
Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma
Farquhar, N., Thornton, S., Coupland, S. E., Coulson, J., Sacco, J. J., Krishna, Y., . . . Kalirai, H. (2018). Patterns of BAP1 protein expression provide insights into prognostic significance and the biology of uveal melanoma. The Journal of Pathology: Clinical Research, 4(1), 26-38. doi:10.1002/cjp2.86
2017
1111. Inflammatory cell infiltrates in metastatic uveal melanoma
Krishna, Y., McCarthy, C., Kalirai, H., & Coupland, S. (2017). 1111. Inflammatory cell infiltrates in metastatic uveal melanoma. European Journal of Surgical Oncology, 43(11), 2206. doi:10.1016/j.ejso.2017.10.083
Chronic Lymphocytic Leukaemia/Small-Cell Lymphocytic Lymphoma of the Lacrimal Sac: A Case Series
Krishna, Y., Irion, L. D., Karim, S., Dharmsena, A., McCormick, A., & Coupland, S. E. (2017). Chronic Lymphocytic Leukaemia/Small-Cell Lymphocytic Lymphoma of the Lacrimal Sac: A Case Series. OCULAR ONCOLOGY AND PATHOLOGY, 3(3), 224-228. doi:10.1159/000455148
Inflammatory cell infiltrates in advanced metastatic uveal melanoma
Krishna, Y., McCarthy, C., Kalirai, H., & Coupland, S. E. (2017). Inflammatory cell infiltrates in advanced metastatic uveal melanoma. HUMAN PATHOLOGY, 66, 159-166. doi:10.1016/j.humpath.2017.06.005
Recurrent chordoma with orbital and eyelid invasion
Krishna, Y., Qureshi, S., McCormick, A., & Coupland, S. E. (2017). Recurrent chordoma with orbital and eyelid invasion. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 255(7), 1443-1446. doi:10.1007/s00417-017-3646-5
Lacrimal Sac Tumors--A Review.
Krishna, Y., & Coupland, S. E. (2017). Lacrimal Sac Tumors--A Review.. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.), 6(2), 173-178. doi:10.22608/apo.201713
2016
Diffuse Histiocytic Sarcoma Involving the Choroid
Krishna, Y., Araujo, I., Warrier, S., Heimann, H., & Coupland, S. E. (2016). Diffuse Histiocytic Sarcoma Involving the Choroid. JAMA OPHTHALMOLOGY, 134(10), 1198-1200. doi:10.1001/jamaophthalmol.2016.2867
Genetic Variants of the <i>BTNL2</i> Gene in Uveal Melanoma
Coupland, S. E., & Krishna, Y. (2016). Genetic Variants of the <i>BTNL2</i> Gene in Uveal Melanoma. JAMA OPHTHALMOLOGY, 134(10), 1133-1134. doi:10.1001/jamaophthalmol.2016.2940
Inflammatory cell infiltrates in metastatic uveal melanoma
Krishna, Y., McCarthy, C., Kalirai, H., & Coupland, S. (2016). Inflammatory cell infiltrates in metastatic uveal melanoma. In ACTA OPHTHALMOLOGICA Vol. 94. doi:10.1111/j.1755-3768.2016.0521
Genetic findings in treatment-naive and proton-beam-radiated iris melanomas
Krishna, Y., Kalirai, H., Thornton, S., Damato, B. E., Heimann, H., & Coupland, S. E. (2016). Genetic findings in treatment-naive and proton-beam-radiated iris melanomas. BRITISH JOURNAL OF OPHTHALMOLOGY, 100(7), 1012-1016. doi:10.1136/bjophthalmol-2015-308301
2015
Transplant Rejection Following Endothelial Keratoplasty and Penetrating Keratoplasty in the United Kingdom: Incidence and Survival
Figueiredo, G. S. M., Jones, M. N. A., Krishna, Y., Figueiredo, F. C. D., Larkin, D. F. P., & Kaye, S. B. (2015). Transplant Rejection Following Endothelial Keratoplasty and Penetrating Keratoplasty in the United Kingdom: Incidence and Survival. AMERICAN JOURNAL OF OPHTHALMOLOGY, 160(3), 416-421. doi:10.1016/j.ajo.2015.06.012
2013
Novel Heavy Tamponade for Vitreoretinal Surgery
Williams, R. L., Kearns, V. R., Lo, A. C., Day, M., Garvey, M. J., Krishna, Y., . . . Wong, D. (2013). Novel Heavy Tamponade for Vitreoretinal Surgery. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 54(12), 7284-7292. doi:10.1167/iovs.13-11876
2012
Plasma polymer coatings to aid retinal pigment epithelial growth for transplantation in the treatment of age related macular degeneration
Kearns, V., Mistry, A., Mason, S., Krishna, Y., Sheridan, C., Short, R., & Williams, R. L. (2012). Plasma polymer coatings to aid retinal pigment epithelial growth for transplantation in the treatment of age related macular degeneration. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 23(8), 2013-2021. doi:10.1007/s10856-012-4675-6
2011
Expanded polytetrafluoroethylene as a substrate for retinal pigment epithelial cell growth and transplantation in age-related macular degeneration
Krishna, Y., Sheridan, C., Kent, D., Kearns, V., Grierson, I., & Williams, R. (2011). Expanded polytetrafluoroethylene as a substrate for retinal pigment epithelial cell growth and transplantation in age-related macular degeneration. BRITISH JOURNAL OF OPHTHALMOLOGY, 95(4), 569-573. doi:10.1136/bjo.2009.169953
2007
Transplantation in the treatment of age-related macular degeneration: past, present and future directions
Sheridan, C., Krishna, Y., Williams, R., Mason, S., Wong, D., Heimann, H., . . . Grierson, I. (2007). Transplantation in the treatment of age-related macular degeneration: past, present and future directions. Expert Review of Ophthalmology, 2(3), 497-511. doi:10.1586/17469899.2.3.497
Polydimethylsiloxane as a substrate for retinal pigment epithelial cell growth
Krishna, Y., Sheridan, C. M., Kent, D. L., Grierson, I., & Williams, R. L. (2007). Polydimethylsiloxane as a substrate for retinal pigment epithelial cell growth. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 80A(3), 669-678. doi:10.1002/jbm.a.30953
2005
Polyurethanes as potential substrates for sub-retinal retinal pigment epithelial cell transplantation
Williams, R. L., Krishna, Y., Dixon, S., Haridas, A., Grierson, I., & Sheridan, C. (2005). Polyurethanes as potential substrates for sub-retinal retinal pigment epithelial cell transplantation. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 16(12), 1087-1092. doi:10.1007/s10856-005-4710-y
Patient attitudes to receiving copies of outpatient clinic letters from the ocular oncologist to the referring ophthalmologist and GP
Krishna, Y., & Damato, B. E. (2005). Patient attitudes to receiving copies of outpatient clinic letters from the ocular oncologist to the referring ophthalmologist and GP. EYE, 19(11), 1200-1204. doi:10.1038/sj.eye.6701740