Research outputs
2026
Breast Cancer Disparities in African and African-Ancestry Populations: Genetics, Epigenetics, Structural Barriers and Technology-Enabled Solutions
Eze, C., Swadi, R., Ross, K., & Sharma, V. (2026). Breast Cancer Disparities in African and African-Ancestry Populations: Genetics, Epigenetics, Structural Barriers and Technology-Enabled Solutions. British Journal of Biomedical Science, 83. doi:10.3389/bjbs.2026.16013
Protocol for Establishing National Guidance for Idiopathic Granulomatous Mastitis (ENIGMA).
Shah, S., Argus, L., Johri, G., Ahari, D., Castelhano, R., Christoforidis, S., . . . North West Breast Research Collaborative. (2025). Protocol for Establishing National Guidance for Idiopathic Granulomatous Mastitis (ENIGMA).. BJS open, 10(1), zraf141. doi:10.1093/bjsopen/zraf141
The Application of Artificial Intelligence to Histopathology
Sharma, V. (2025). The Application of Artificial Intelligence to Histopathology. In Digital Healthcare and Artificial Intelligence (pp. 99-108). CRC Press. doi:10.1201/9781032709956-11
2025
Establishing National Guidance for Idiopathic Granulomatous Mastitis (ENIGMA): a scoping review of diagnostic practice.
Argus, L., Sharma, V., Darlow, C., Sethi, K., Lyburn, I., Sharma, N., . . . Kirwan, C. C. (2025). Establishing National Guidance for Idiopathic Granulomatous Mastitis (ENIGMA): a scoping review of diagnostic practice.. Journal of clinical pathology, jcp-2025-210394. doi:10.1136/jcp-2025-210394
The Liverpool Diagnostic Infrared Wand (LDIR wand): Imaging and Cancer Prognosis from the Same Technology
Sharma, V. (2025). The Liverpool Diagnostic Infrared Wand (LDIR wand): Imaging and Cancer Prognosis from the Same Technology. infocus Magazine, 4-8. doi:10.22443/rms.inf.1.305
Ki67 Spatial Hotspot Analysis Before and After Neoadjuvant Therapy Reveals Novel Predictive Information about the Evolution of Breast Tumours
Sharma, V. (n.d.). Ki67 Spatial Hotspot Analysis Before and After Neoadjuvant Therapy Reveals Novel Predictive Information about the Evolution of Breast Tumours.
2024
Abstract B012: Understanding the role of VISTA in regulating T cell function and the therapeutic potential of blocking VISTA in triple negative breast cancer
Abudula, M., Astuti, Y., Raymant, M. R., Sharma, V., Schmid, M., & Mielgo, A. (2024). Abstract B012: Understanding the role of VISTA in regulating T cell function and the therapeutic potential of blocking VISTA in triple negative breast cancer. Cancer Research, 84(22_Supplement), B012. doi:10.1158/1538-7445.tumbody-b012
ENO1 as a Biomarker of Breast Cancer Progression and Metastasis: A Bioinformatic Approach Using Available Databases
Giannoudis, A., Heath, A., & Sharma, V. (2024). ENO1 as a Biomarker of Breast Cancer Progression and Metastasis: A Bioinformatic Approach Using Available Databases. Breast Cancer: Basic and Clinical Research, 18. doi:10.1177/11782234241285648
Morphological and molecular changes of oestrogen receptor-positive breast cancer following bridging endocrine therapy: a United Kingdom multicentre study.
Miligy, I. M., Awasthi, R., Mir, Y., Khurana, A., Sharma, V., Chandaran, U., . . . Shaaban, A. M. (2024). Morphological and molecular changes of oestrogen receptor-positive breast cancer following bridging endocrine therapy: a United Kingdom multicentre study.. Histopathology, 85(3), 405-417. doi:10.1111/his.15238
Pathological Changes Following Neoadjuvant Endocrine Therapy (NAET): A Multicentre Study of 391 Breast Cancers
Miligy, I. M., Badr, N., Stevens, A., Spooner, D., Awasthi, R., Mir, Y., . . . Shaaban, A. M. (2024). Pathological Changes Following Neoadjuvant Endocrine Therapy (NAET): A Multicentre Study of 391 Breast Cancers. International Journal of Molecular Sciences, 25(13), 7381. doi:10.3390/ijms25137381
A Bioinformatic Characterisation of the Glyolytic Enzyme ENO1 as a Biomarker of Breast Cancer Progression
2023
The Current and Evolving Landscape of Breast Cancer Prediction and Prognosis
Sharma, V. (2023). The Current and Evolving Landscape of Breast Cancer Prediction and Prognosis. Medical Research Archives, 11(12). doi:10.18103/mra.v11i12.4912
ENO1 as a biomarker of breast cancer progression and metastasis – a bioinformatic approach
2022
Characterisation of the immune microenvironment of primary breast cancer and brain metastasis reveals depleted T-cell response associated to ARG2 expression
Giannoudis, A., Vareslija, D., Sharma, V., Zakaria, R., Platt-Higgins, A., Rudland, P. S., . . . Palmieri, C. (2022). Characterisation of the immune microenvironment of primary breast cancer and brain metastasis reveals depleted T-cell response associated to ARG2 expression. ESMO OPEN, 7(6). doi:10.1016/j.esmoop.2022.100636
The role of CPT1A as a biomarker of breast cancer progression: a bioinformatic approach
Das, M., Giannoudis, A., & Sharma, V. (2022). The role of CPT1A as a biomarker of breast cancer progression: a bioinformatic approach. SCIENTIFIC REPORTS, 12(1). doi:10.1038/s41598-022-20585-x
Control of Fatty Acid Oxidation by the Sympathetic Nervous System in the Diabetic Heart: Implications for Both Heart Failure and Cancer
Sharma, V., & McNeill, J. H. (2022). Control of Fatty Acid Oxidation by the Sympathetic Nervous System in the Diabetic Heart: Implications for Both Heart Failure and Cancer. In R. W. Sowadogo (Ed.), Current Innovations in Medicine and Medical Science Volume 2 (pp. 1-20). B P International.
The importance of ARG2 expression in the immune-depleted microenvironment of primary breast cancer and brain metastasis
Giannoudis, A., Vareslija, D., Sharma, V., Zakaria, R., Platt-Higgins, A., Rudland, P., . . . Palmieri, C. (2022). The importance of ARG2 expression in the immune-depleted microenvironment of primary breast cancer and brain metastasis. In ANNALS OF ONCOLOGY Vol. 33 (pp. S132). doi:10.1016/j.annonc.2022.03.035
The Role of CPT1A as a Biomarker of Breast Cancer Progression – A Bioinformatic Analysis
The Role of CPT1A as a Biomarker of Breast Cancer Progression – a Bioinformatic Analysis
2016
The Application of Chaos Theory and Fractal Mathematics to the Study of Cancer Evolution: Placing Metabolism and Immunity Centre Stage
Sharma, V. (2016). The Application of Chaos Theory and Fractal Mathematics to the Study of Cancer Evolution: Placing Metabolism and Immunity Centre Stage. Medical Research Archives, 4(6). doi:10.18103/mra.v4i6.717
2015
Fatal Kikuchi-like lymphadenitis associated with connective tissue disease: a report of two cases and review of the literature.
Sharma, V., & Rankin, R. (2015). Fatal Kikuchi-like lymphadenitis associated with connective tissue disease: a report of two cases and review of the literature.. SpringerPlus, 4, 167. doi:10.1186/s40064-015-0925-7
2014
Combined metoprolol and ascorbic acid treatment prevents intrinsic damage to the heart during diabetic cardiomyopathy.
Saran, V., Sharma, V., Wambolt, R., Yuen, V. G., Allard, M., & McNeill, J. H. (2014). Combined metoprolol and ascorbic acid treatment prevents intrinsic damage to the heart during diabetic cardiomyopathy.. Canadian journal of physiology and pharmacology, 92(10), 827-837. doi:10.1139/cjpp-2014-0078
Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes
Sharma, V., & McNeill, J. H. (2014). Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes. In Cardiac Energy Metabolism in Health and Disease (pp. 131-153). Springer New York. doi:10.1007/978-1-4939-1227-8_9
Metabolic and Contractile Remodelling in the Diabetic Heart: An Evolutionary Perspective
Sharma, V., & McNeill, J. H. (2014). Metabolic and Contractile Remodelling in the Diabetic Heart: An Evolutionary Perspective. In DIABETIC CARDIOMYOPATHY: BIOCHEMICAL AND MOLECULAR MECHANISMS (Vol. 9, pp. 27-40). doi:10.1007/978-1-4614-9317-4_2
2013
A new approach for measuring the work and quality of histopathology reporting
Sharma, V., Davey, J. G. N., Humphreys, C., & Johnston, P. W. (2013). A new approach for measuring the work and quality of histopathology reporting. HISTOPATHOLOGY, 63(1), 130-136. doi:10.1111/his.12144
Mortality in a teaching hospital during junior doctor changeover: a regional and national comparison
Sharma, V., Proctor, I., & Winstanley, A. (2013). Mortality in a teaching hospital during junior doctor changeover: a regional and national comparison. BRITISH JOURNAL OF HOSPITAL MEDICINE, 74(3), 167-169. doi:10.12968/hmed.2013.74.3.167
2012
Does smoking kill? A study of death certification and smoking
Proctor, I., Sharma, V., KhoshZaban, M., & Winstanley, A. (2012). Does smoking kill? A study of death certification and smoking. JOURNAL OF CLINICAL PATHOLOGY, 65(2), 129-132. doi:10.1136/jclinpath-2011-200299
Explanatory models are needed to integrate RCT and observational data with the patient's unique biology
Sharma, V., & Minhas, R. (2012). Explanatory models are needed to integrate RCT and observational data with the patient's unique biology. JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 105(1), 11-24. doi:10.1258/jrsm.2011.110236
2011
Parallel effects of β-adrenoceptor blockade on cardiac function and fatty acid oxidation in the diabetic heart: Confronting the maze.
Sharma, V., & McNeill, J. H. (2011). Parallel effects of β-adrenoceptor blockade on cardiac function and fatty acid oxidation in the diabetic heart: Confronting the maze.. World journal of cardiology, 3(9), 281-302. doi:10.4330/wjc.v3.i9.281
Cardiac Dysfunction and Metabolism: Unravelling the Molecular Cross-Talk
Sharma, V., & McNeill, J. H. (2011). Cardiac Dysfunction and Metabolism: Unravelling the Molecular Cross-Talk. In MOLECULAR DEFECTS IN CARDIOVASCULAR DISEASE (pp. 109-125). doi:10.1007/978-1-4419-7130-2_9
β-receptor antagonist treatment prevents activation of cell death signaling in the diabetic heart independent of its metabolic actions
Sharma, V., Sharma, A., Saran, V., Bernatchez, P. N., Allard, M. F., & McNeill, J. H. (2011). β-receptor antagonist treatment prevents activation of cell death signaling in the diabetic heart independent of its metabolic actions. EUROPEAN JOURNAL OF PHARMACOLOGY, 657(1-3), 117-125. doi:10.1016/j.ejphar.2011.01.044
2010
Functional effects of protein kinases and peroxynitrite on cardiac carnitine palmitoyltransferase-1 in isolated mitochondria
Sharma, V., Abraham, T., So, A., Allard, M. F., & McNeill, J. H. (2010). Functional effects of protein kinases and peroxynitrite on cardiac carnitine palmitoyltransferase-1 in isolated mitochondria. MOLECULAR AND CELLULAR BIOCHEMISTRY, 337(1-2), 223-237. doi:10.1007/s11010-009-0303-2
Modulation of Cardiac Metabolism by Beta‐Blockers During Diabetes: A Role in Apoptosis Signaling
Saran, V. V. V., Sharma, V., Yuen, V., Allard, M. F., & McNeill, J. H. (2010). Modulation of Cardiac Metabolism by Beta‐Blockers During Diabetes: A Role in Apoptosis Signaling. The FASEB Journal, 24(S1). doi:10.1096/fasebj.24.1_supplement.lb411
2009
Deterministic chaos and fractal complexity in the dynamics of cardiovascular behavior: perspectives on a new frontier.
Sharma, V., & Sharma, V. (2009). Deterministic chaos and fractal complexity in the dynamics of cardiovascular behavior: perspectives on a new frontier.. The open cardiovascular medicine journal, 3, 110-123. doi:10.2174/1874192400903010110
Stimulation of cardiac fatty acid oxidation by leptin is mediated by a nitric oxide-p38 MAPK-dependent mechanism
Sharma, V., Mustafa, S., Patel, N., Wambolt, R., Allard, M. F., & McNeill, J. H. (2009). Stimulation of cardiac fatty acid oxidation by leptin is mediated by a nitric oxide-p38 MAPK-dependent mechanism. EUROPEAN JOURNAL OF PHARMACOLOGY, 617(1-3), 113-117. doi:10.1016/j.ejphar.2009.06.037
To scale or not to scale: the principles of dose extrapolation
Sharma, V., & McNeill, J. H. (2009). To scale or not to scale: the principles of dose extrapolation. BRITISH JOURNAL OF PHARMACOLOGY, 157(6), 907-921. doi:10.1111/j.1476-5381.2009.00267.x
Insulin resistance and endothelial dysfunction: Are epoxyeicosatrienoic acids the link?
Mustafa, S., Sharma, V., & McNeill, J. H. (2009). Insulin resistance and endothelial dysfunction: Are epoxyeicosatrienoic acids the link?. EXPERIMENTAL & CLINICAL CARDIOLOGY, 14(2), E41-E50. Retrieved from https://www.webofscience.com/
Metabolic and structural remodeling of heart‐derived H9c2 cells by AMPK activation
Dai, J. M., Saeedi, R., Sharma, V., Saran, V., Parsons, H., Dyck, J., & Allard, M. (2009). Metabolic and structural remodeling of heart‐derived H9c2 cells by AMPK activation. The FASEB Journal, 23(S1). doi:10.1096/fasebj.23.1_supplement.577.9
Metoprolol represses PGC1α-mediated carnitine palmitoyltransferase-1B expression in the diabetic heart
Sharma, V., Dhillon, P., Parsons, H., Allard, M. F., & McNeill, J. H. (2009). Metoprolol represses PGC1α-mediated carnitine palmitoyltransferase-1B expression in the diabetic heart. EUROPEAN JOURNAL OF PHARMACOLOGY, 607(1-3), 156-166. doi:10.1016/j.ejphar.2009.02.016
2008
Metoprolol increases the expression of β<sub>3</sub>-adrenoceptors in the diabetic heart:: Effects on nitric oxide signaling and forkhead transcription factor-3
Sharma, V., Parsons, H., Allard, M. F., & McNeill, J. H. (2008). Metoprolol increases the expression of β<sub>3</sub>-adrenoceptors in the diabetic heart:: Effects on nitric oxide signaling and forkhead transcription factor-3. EUROPEAN JOURNAL OF PHARMACOLOGY, 595(1-3), 44-51. doi:10.1016/j.ejphar.2008.07.042
Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms
Saeedi, R., Parsons, H. L., Wambolt, R. B., Paulson, K., Sharma, V., Dyck, J. R. B., . . . Allard, M. F. (2008). Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 294(6), H2497-H2506. doi:10.1152/ajpheart.00873.2007
Metoprolol improves cardiac function and modulates cardiac metabolism in the streptozotocin-diabetic rat
Sharma, V., Dhillon, P., Wambolt, R., Parsons, H., Brownsey, R., Allard, M. F., & McNeill, J. H. (2008). Metoprolol improves cardiac function and modulates cardiac metabolism in the streptozotocin-diabetic rat. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 294(4), H1609-H1620. doi:10.1152/ajpheart.00949.2007
Phosphorylation of carnitine palmitoyltransferase‐1 in heart mitochondria
Sharma, V., Parsons, H., Allard, M. F., & McNeill, J. H. (2008). Phosphorylation of carnitine palmitoyltransferase‐1 in heart mitochondria. The FASEB Journal, 22(S1). doi:10.1096/fasebj.22.1_supplement.1129.20
2007
An appraisal of trauma in the elderly
Sharma, O. P., Oswanski, M. F., Sharma, V., Stringfellow, K., & Raj, S. S. (2007). An appraisal of trauma in the elderly. AMERICAN SURGEON, 73(4), 354-358. Retrieved from https://www.webofscience.com/
AMPK control of myocardial fatty acid metabolism fluctuates with the intensity of insulin-deficient diabetes
Kewalramani, G., An, D., Kim, M. S., Ghosh, S., Qi, D., Abrahani, A., . . . Rodrigues, B. (2007). AMPK control of myocardial fatty acid metabolism fluctuates with the intensity of insulin-deficient diabetes. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 42(2), 333-342. doi:10.1016/j.yjmcc.2006.11.010
Modulation of CPT-1 activity and sensitivity by metoprolol
Sharma, V., Wambolt, R., Parsons, H., Allard, M. F., & McNeill, J. H. (2007). Modulation of CPT-1 activity and sensitivity by metoprolol. FASEB JOURNAL, 21(6), A801. Retrieved from https://www.webofscience.com/
2006
<i>N</i>-acetylcysteine attenuates TNF-α-induced human vascular endothelial cell apoptosis and restores eNOS expression
Xia, Z., Liu, M., Wu, Y., Sharma, V., Luo, T., Ouyang, J., & McNeill, J. H. (2006). <i>N</i>-acetylcysteine attenuates TNF-α-induced human vascular endothelial cell apoptosis and restores eNOS expression. EUROPEAN JOURNAL OF PHARMACOLOGY, 550(1-3), 134-142. doi:10.1016/j.ejphar.2006.08.044
The Metabolic Syndrome: Revisiting the Concept, the Diagnosis and the Treatment (Part-II)
Sharma, V., & McNeill, J. H. (Eds.) (2006). The Metabolic Syndrome: Revisiting the Concept, the Diagnosis and the Treatment (Part-II) (Vol. 4).
The etiology of hypertension in the metabolic syndrome part four: the systemic perspective--the role of the neuroendocrine and immune systems, and the challenge of integration.
Sharma, V., & McNeill, J. H. (2006). The etiology of hypertension in the metabolic syndrome part four: the systemic perspective--the role of the neuroendocrine and immune systems, and the challenge of integration.. Current vascular pharmacology, 4(4), 349-381. doi:10.2174/157016106778521599
The etiology of hypertension in the metabolic syndrome part one: an introduction to the history, the concept and the models.
Sharma, V., & McNeill, J. H. (2006). The etiology of hypertension in the metabolic syndrome part one: an introduction to the history, the concept and the models.. Current vascular pharmacology, 4(4), 293-304. doi:10.2174/157016106778521616
The etiology of hypertension in the metabolic syndrome part three: the regulation and dysregulation of blood pressure.
Sharma, V., & McNeill, J. H. (2006). The etiology of hypertension in the metabolic syndrome part three: the regulation and dysregulation of blood pressure.. Current vascular pharmacology, 4(4), 321-348. doi:10.2174/157016106778521643
The etiology of hypertension in the metabolic syndrome part two: the gene-environment interaction.
Sharma, V., & McNeill, J. H. (2006). The etiology of hypertension in the metabolic syndrome part two: the gene-environment interaction.. Current vascular pharmacology, 4(4), 305-320. doi:10.2174/157016106778521661
Metabolic Syndrome: Revisiting the Concept, the Diagnosis and the Treatment (Part-I)
Sharma, V., & McNeill, J. H. (Eds.) (2006). Metabolic Syndrome: Revisiting the Concept, the Diagnosis and the Treatment (Part-I) (Vol. 4).
Diabetic cardiomyopathy: Where are we 40 years later?
Sharma, V., & McNeill, J. H. (2006). Diabetic cardiomyopathy: Where are we 40 years later?. CANADIAN JOURNAL OF CARDIOLOGY, 22(4), 305-308. doi:10.1016/S0828-282X(06)70914-X
2005
N-acetylcysteine dose-dependently reduces TNF-α cellular toxicity
Ouyang, J., Xia, Z., Luo, T., Liu, M., Sharma, V., & McNeill, J. H. (2005). N-acetylcysteine dose-dependently reduces TNF-α cellular toxicity. Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 52(S1), A212. doi:10.1007/bf03023250
Vanadium complexes with mixed <i>O</i>,<i>S</i> anionic ligands derived from maltol: Synthesis, characterization, and biological studies
Monga, V., Thompson, K. H., Yuen, V. G., Sharma, V., Patrick, B. O., McNeill, J. H., & Orvig, C. (2005). Vanadium complexes with mixed <i>O</i>,<i>S</i> anionic ligands derived from maltol: Synthesis, characterization, and biological studies. INORGANIC CHEMISTRY, 44(8), 2678-2688. doi:10.1021/ic0486926
The emerging roles of leptin and ghrelin in cardiovascular physiology and pathophysiology.
Sharma, V., & McNeill, J. H. (2005). The emerging roles of leptin and ghrelin in cardiovascular physiology and pathophysiology.. Current vascular pharmacology, 3(2), 169-180. doi:10.2174/1570161053586868
2002
Vanadium increases GLUT4 in diabetic rat skeletal muscle
Mohammad, A., Sharma, V., & McNeill, J. H. (2002). Vanadium increases GLUT4 in diabetic rat skeletal muscle. MOLECULAR AND CELLULAR BIOCHEMISTRY, 233(1-2), 139-143. doi:10.1023/A:1015558328757