Research outputs
Selected research outputs
- Redox changes in obesity, metabolic syndrome, and diabetes (Journal article - 2021)
- Adult stem cell maintenance and tissue regeneration around the clock: do impaired stem cell clocks drive age-associated tissue degeneration? (Journal article - 2018)
- N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene (Journal article - 2018)
- Comparing Circadian Dynamics in Primary Derived Stem Cells from Different Sources of Human Adult Tissue (Journal article - 2017)
- Cellular mechano-environment regulates the mammary circadian clock (Journal article - 2017)
- Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression (Journal article - 2016)
- The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis (Journal article - 2014)
- Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation (Journal article - 2011)
- The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation (Journal article - 2008)
- Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts (Journal article - 2007)
2025
Nrf2-driven redox coupling of tumour and associated adipose tissue during early tumour growth in an orthotopic breast cancer model.
Zakic, T., Jevtic, J., Vukobratovic, M., Djuric, S., Golic, I., Korac, A., . . . Korac, B. (2025). Nrf2-driven redox coupling of tumour and associated adipose tissue during early tumour growth in an orthotopic breast cancer model.. Free Radic Biol Med, 239, 63-79. doi:10.1016/j.freeradbiomed.2025.07.027
Long-term consequences of gestational protein restriction on skeletal muscle development in male offspring
Altinpinar, A. E., Kanakis, I., Ozanne, S. E., Pekovic-Vaughan, V., Goljanek-Whysall, K., & Vasilaki, A. (2025). Long-term consequences of gestational protein restriction on skeletal muscle development in male offspring. Free Radical Biology and Medicine, 233, S14. doi:10.1016/j.freeradbiomed.2025.05.055
Nrf2/AMPK axis is required for redox-mediated phase resetting of musculoskeletal clocks upon acute mechanical loading
Ersoy, U., Sibel, C., Winstanley-Zarach, P., Dikmen, T., Poulet, B., & Pekovic-Vaughan, V. (2025). Nrf2/AMPK axis is required for redox-mediated phase resetting of musculoskeletal clocks upon acute mechanical loading. Free Radical Biology and Medicine, 233, S75-S76. doi:10.1016/j.freeradbiomed.2025.05.266
A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts.
Thoma, A., Alomosh, R., Bond, H. L., Akter-Miah, T., Al-Shanti, N., Degens, H., . . . Lightfoot, A. P. (2025). A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts.. Journal of cellular physiology, 240(1), e31458. doi:10.1002/jcp.31458
2024
Mechanical stretch and chronotherapeutic techniques for progenitor cell transplantation and biomaterials
Rogers, E. H., Pekovic-Vaughan, V., & Hunt, J. A. (2024). Mechanical stretch and chronotherapeutic techniques for progenitor cell transplantation and biomaterials. BioMedicine, 8(3), 14. doi:10.37796/2211-8039.1584
Maternal Low-Protein Diet Impairs Skeletal Muscle Development, Inflammatory Responses, and Mitochondrial Function in Offspring: Long-Term Effects on Muscle Ageing
Altinpinar, A. E., Ersoy, U., Alameddine, M., Kanakis, I., Pekovic-Vaughan, V., Goljanek-Whysall, K., & Vasilaki, A. (2024). Maternal Low-Protein Diet Impairs Skeletal Muscle Development, Inflammatory Responses, and Mitochondrial Function in Offspring: Long-Term Effects on Muscle Ageing. Free Radical Biology and Medicine, 224, S104. doi:10.1016/j.freeradbiomed.2024.10.230
Redox and metabolic reprogramming in breast cancer and cancer-associated adipose tissue.
Zakic, T., Pekovic-Vaughan, V., Cvoro, A., Korac, A., Jankovic, A., & Korac, B. (2024). Redox and metabolic reprogramming in breast cancer and cancer-associated adipose tissue.. FEBS letters, 598(17), 2106-2134. doi:10.1002/1873-3468.14794
NRF2/AMPK AXIS IS REQUIRED FOR REDOX-MEDIATED PHASE RESETTING OF MUSCULOSKELETAL CLOCKS UPON ACUTE MECHANICAL LOADING
Ersoy, U., Winstanley-Zarach, P., Poulet, B., & Pekovic-Vaughan, V. (2024). NRF2/AMPK AXIS IS REQUIRED FOR REDOX-MEDIATED PHASE RESETTING OF MUSCULOSKELETAL CLOCKS UPON ACUTE MECHANICAL LOADING. RedoXplore, 1(1). doi:10.70200/rx202401038e
Lifelong effects of maternal low protein diet on skeletal muscle development and ageing in male offsprings
Altinpinar, A. E., Ersoy, U., Alameddine, M., Pekovic-Vaughan, V., Kanakis, I., Whysall, K. G., & Vasilaki, A. (2024). Lifelong effects of maternal low protein diet on skeletal muscle development and ageing in male offsprings. Free Radical Biology and Medicine, 218, 39. doi:10.1016/j.freeradbiomed.2024.04.142
The role of Nrf2 in redox coupling of tumor and adipose tissue in orthotopic breast cancer model
Zakic, T., Vukobratovic, M., Djuric, S., Korac, A., Pekovic-Vaughan, V., Jankovic, A., & Korac, B. (2024). The role of Nrf2 in redox coupling of tumor and adipose tissue in orthotopic breast cancer model. Free Radical Biology and Medicine, 218, 15-16. doi:10.1016/j.freeradbiomed.2024.04.060
Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.
Dalby, M. J., Pekovic-Vaughan, V., Shanley, D. P., Swift, J., White, L. J., & Canty-Laird, E. G. (2024). Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.. BioEssays : news and reviews in molecular, cellular and developmental biology, 46(5), e2300223. doi:10.1002/bies.202300223
A combination of major histocompatibility complex (MHC) I overexpression and type I interferon induce mitochondrial dysfunction in human skeletal myoblasts
2023
ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING
Pekovic-Vaughan, V., Sutton, E., Carter, A., Fawcett, S., Moore, H., Sarumi, D., & Bou-Gharios, G. (2023). ANTIOXIDANT TRANSCRIPTION FACTOR NRF2 REGULATES SKELETAL MUSCLE HOMEOSTASIS THROUGH A CIRCADIAN MECHANISM THAT IS DISRUPTED WITH AGEING. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 201 (pp. 4). doi:10.1016/j.freeradbiomed.2023.03.042
THE DISCREPANCY BETWEEN MORPHOLOGICAL AND FUNCTIONAL ACTIVATION OF BROWN ADIPOSE TISSUE IN THE ABSENCE OF FUNCTIONAL NRF2
Zakic, T., Soskic, M. B., Stojanovic, S., Jankovic, A., Korac, A., Pekovic-Vaughan, V., & Korac, B. (2023). THE DISCREPANCY BETWEEN MORPHOLOGICAL AND FUNCTIONAL ACTIVATION OF BROWN ADIPOSE TISSUE IN THE ABSENCE OF FUNCTIONAL NRF2. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 201 (pp. 25). doi:10.1016/j.freeradbiomed.2023.03.109
Shorter sleep duration is associated with greater visceral fat mass in US adults: Findings from NHANES, 2011-2014.
Giannos, P., Prokopidis, K., Candow, D. G., Forbes, S. C., Celoch, K., Isanejad, M., . . . Scott, D. (2023). Shorter sleep duration is associated with greater visceral fat mass in US adults: Findings from NHANES, 2011-2014.. Sleep medicine, 105, 78-84. doi:10.1016/j.sleep.2023.03.013
2022
Redox-metabolic reprogramming of skin in mice lacking functional Nrf2 under basal conditions and cold acclimation
Zakic, T., Stojanovic, S., Jankovic, A., Korac, A., Pekovic-Vaughan, V., & Korac, B. (2022). Redox-metabolic reprogramming of skin in mice lacking functional Nrf2 under basal conditions and cold acclimation. BIOFACTORS. doi:10.1002/biof.1931
STRUCTURAL AND REDOX-METABOLIC REMODELLING OF BROWN ADIPOSE TISSUE IN MICE LACKING NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2 UNDER BASAL CONDITIONS AND COLD ACCLIMATION
Zakic, T., Ninkovic, A., Stojanovic, S., Soskic, M. B., Kalezic, A., Jankovic, A., . . . Korac, B. (2022). STRUCTURAL AND REDOX-METABOLIC REMODELLING OF BROWN ADIPOSE TISSUE IN MICE LACKING NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 2 UNDER BASAL CONDITIONS AND COLD ACCLIMATION. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 189 (pp. 5-6). Retrieved from https://www.webofscience.com/
2021
A novel role for an antioxidant transcription factor <i>Nrf2</i> as a transcriptional repressor of the circadian molecular clock
Sutton, E., Carter, A., Fawcett, S., Sarumi, D., Copple, I., & Pekovic-Vaughan, V. (2021). A novel role for an antioxidant transcription factor <i>Nrf2</i> as a transcriptional repressor of the circadian molecular clock. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177. doi:10.1016/j.freeradbiomed.2021.08.103
NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions
Sutton, E., Early, J., Hughes, A., Gall, L., Carter, A., Copple, I., . . . Pekovic-Vaughan, V. (2021). NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177. doi:10.1016/j.freeradbiomed.2021.08.042
Redox changes in obesity, metabolic syndrome, and diabetes
Korac, B., Kalezic, A., Pekovic-Vaughan, V., Korac, A., & Jankovic, A. (2021). Redox changes in obesity, metabolic syndrome, and diabetes. REDOX BIOLOGY, 42. doi:10.1016/j.redox.2021.101887
2019
Antioxidant transcription factor Nrf2 and the circadian molecular clock interact in a tissue-specific, bi-directional manner
Sutton, E., Carter, A., Early, J., Fawcett, S., Sarumi, D., Bechtold, D., & Pekovic-Vaughan, V. (2019). Antioxidant transcription factor Nrf2 and the circadian molecular clock interact in a tissue-specific, bi-directional manner. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 139 (pp. S52). Retrieved from https://www.webofscience.com/
The role of Cryptochrome1/2 proteins in the regulation of TGF-β1 signalling pathway and their implication in tissue fibrosis
Sarumi, D., Carter, A., Fawcett, S. A., Sutton, E., Van derhorst, G. T. J., Kearns, V., . . . Pekovic-Vaughan, V. (2019). The role of Cryptochrome1/2 proteins in the regulation of TGF-β1 signalling pathway and their implication in tissue fibrosis. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 100 (pp. A45). Retrieved from https://www.webofscience.com/
2018
Adult stem cell maintenance and tissue regeneration around the clock: do impaired stem cell clocks drive age-associated tissue degeneration?
Rogers, E. H., Hunt, J. A., & Pekovic-Vaughan, V. (2018). Adult stem cell maintenance and tissue regeneration around the clock: do impaired stem cell clocks drive age-associated tissue degeneration?. BIOGERONTOLOGY, 19(6), 497-517. doi:10.1007/s10522-018-9772-6
Mechanical stretch and chronotherapeutic techniques for progenitor cell transplantation and biomaterials
Rogers, E. H., Pekovic-Vaughan, V., & Hunt, J. A. (2018). Mechanical stretch and chronotherapeutic techniques for progenitor cell transplantation and biomaterials. BIOMEDICINE-TAIWAN, 8(3), 3-12. doi:10.1051/bmdcn/2018080314
N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene
Rodriguez, B. M., Khouzami, L., Decostre, V., Varnous, S., Pekovic-Vaughan, V., Hutchison, C. J., . . . Muchir, A. (2018). N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene. Human Molecular Genetics, 27(19), 3353-3360. doi:10.1093/hmg/ddy243
A novel role for fibrillin 1 in the regulation of clock gene transcription and circadian rhythmicity through the TGF b pathway
Fawcett, S. A., & Pekovic-Vaughan, V. (2018). A novel role for fibrillin 1 in the regulation of clock gene transcription and circadian rhythmicity through the TGF b pathway. In Matrix biology Europe. Manchester.
Cellular mechano-environment regulates the mammary circadian clock
Yang, N., Williams, J., Pekovic-Vaughan, V., Wang, P., Olabi, S., McConnell, J., . . . Meng, Q. J. (2018). Cellular mechano-environment regulates the mammary circadian clock. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 99 (pp. A67). Retrieved from https://www.webofscience.com/
2017
Comparing Circadian Dynamics in Primary Derived Stem Cells from Different Sources of Human Adult Tissue
Rogers, E. H., Fawcett, S. A., Pekovic-Vaughan, V., & Hunt, J. A. (2017). Comparing Circadian Dynamics in Primary Derived Stem Cells from Different Sources of Human Adult Tissue. STEM CELLS INTERNATIONAL, 2017, 13 pages. doi:10.1155/2017/2057168
NRF2/KEAP1-mediated antioxidant defence pathway regulates skeletal muscle circadian clock function
Horton, N. S., Copple, I. M., Vasilaki, A., Jackson, M. J., McArdle, A., & Pekovic-Vaughan, V. (2017). NRF2/KEAP1-mediated antioxidant defence pathway regulates skeletal muscle circadian clock function. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 108 (pp. S48). doi:10.1016/j.freeradbiomed.2017.04.174
Cellular mechano-environment regulates the mammary circadian clock
Yang, N., Williams, J., Pekovic-Vaughan, V., Wang, P., Olabi, S., McConnell, J., . . . Meng, Q. -J. (2017). Cellular mechano-environment regulates the mammary circadian clock. Nature Communications, 8. doi:10.1038/ncomms14287
Ageing-induced osteoarthritis in nrf2 knockout mice
Lyon, M., Pekovic-Vaughan, V., & Poulet, B. (2017). Ageing-induced osteoarthritis in nrf2 knockout mice. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 98 (pp. A4). Retrieved from https://www.webofscience.com/
2016
Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression
Goljanek-Whysall, K., Iwanejko, L. A., Vasilaki, A., Pekovic-Vaughan, V., & McDonagh, B. (2016). Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression. MAMMALIAN GENOME, 27(7-8), 341-357. doi:10.1007/s00335-016-9643-x
Antioxidant transcription factor Nrf2 mediates diurnal control of cutaneous wound repair by a redox mechanism that declines with ageing
Pekovic-Vaughan, V., Carter, A., Marr, N., Roskell, C., Clegg, P., Jackson, M., & Bou-Gharios, G. (2016). Antioxidant transcription factor Nrf2 mediates diurnal control of cutaneous wound repair by a redox mechanism that declines with ageing. Free Radical Biology and Medicine, 96, S40. doi:10.1016/j.freeradbiomed.2016.04.081
Pharmacological manipulation of Nrf2/Keap1-mediated antioxidant defence pathway regulates the circadian clock
Horton, N., Copple, I., Park, K., Jackson, M., McArdle, A., & Pekovic-Vaughan, V. (2016). Pharmacological manipulation of Nrf2/Keap1-mediated antioxidant defence pathway regulates the circadian clock. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 96 (pp. S38-S39). doi:10.1016/j.freeradbiomed.2016.04.077
An ageing matrix weakens the breast circadian clock
Williams, J. L., Yang, N., Pekovic-Vaughan, V., Wang, P., McConnell, J., Olabi, S., . . . Meng, Q. J. (2016). An ageing matrix weakens the breast circadian clock. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A2-A3). Retrieved from https://www.webofscience.com/
Nuclear lamins as mediators of mechano-transduction pathways regulating the temporal activation of circadian clock genes in skeletal muscle cells in response to mechanical cues
Roskell, C., Goldberg, M., Shanley, D., Clegg, P., & Pekovic-Vaughan, V. (2016). Nuclear lamins as mediators of mechano-transduction pathways regulating the temporal activation of circadian clock genes in skeletal muscle cells in response to mechanical cues. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A19-A20). Retrieved from https://www.webofscience.com/
Tissue mechanics control the robustness of the circadian clock
Yang, N., Williams, J., Pekovic-Vaughan, V., Gossan, N., Hughes, A., Cheung, J., . . . Meng, Q. J. (2016). Tissue mechanics control the robustness of the circadian clock. In INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY Vol. 97 (pp. A3). Retrieved from https://www.webofscience.com/
2014
The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis
Pekovic-Vaughan, V., Gibbs, J., Yoshitane, H., Yang, N., Pathiranage, D., Guo, B., . . . Meng, Q. -J. (2014). The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes and Development, 28(6), 548-560. doi:10.1101/gad.237081.113
2011
Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation
Pekovic, V., Gibbs-Seymour, I., Markiewicz, E., Alzoghaibi, F., Benham, A. M., Edwards, R., . . . Hutchison, C. J. (2011). Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation. AGING CELL, 10(6), 1067-1079. doi:10.1111/j.1474-9726.2011.00750.x
A Flow Cytometry-Based Screen of Nuclear Envelope Transmembrane Proteins Identifies NET4/Tmem53 as Involved in Stress-Dependent Cell Cycle Withdrawal
Korfali, N., Srsen, V., Waterfall, M., Batrakou, D. G., Pekovic, V., Hutchison, C. J., & Schirmer, E. C. (2011). A Flow Cytometry-Based Screen of Nuclear Envelope Transmembrane Proteins Identifies NET4/Tmem53 as Involved in Stress-Dependent Cell Cycle Withdrawal. PLOS ONE, 6(4). doi:10.1371/journal.pone.0018762
2009
A-type lamins, disease and ageing: a stress-induced relationship?
Pekovic, V., & Hutchison, C. J. (2009). A-type lamins, disease and ageing: a stress-induced relationship?. In Unknown Book (Vol. 62, pp. 139-170).
2008
The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation
Ojeh, N., Pekovic, V., Jahoda, C., & Maatta, A. (2008). The MAGUK-family protein CASK is targeted to nuclei of the basal epidermis and controls keratinocyte proliferation. JOURNAL OF CELL SCIENCE, 121(16), 2705-2717. doi:10.1242/jcs.025643
Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches
Pekovic, V., & Hutchison, C. J. (2008). Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches. JOURNAL OF ANATOMY, 213(1), 5-25. doi:10.1111/j.1469-7580.2008.00928.x
2007
Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts
Pekovic, V., Harborth, J., Broers, J. L. V., Ramaekers, F. C. S., van Engelen, B., Lammens, M., . . . Markiewicz, E. (2007). Nucleoplasmic LAP2α-lamin A complexes are required to maintain a proliferative state in human fibroblasts. JOURNAL OF CELL BIOLOGY, 176(2), 163-172. doi:10.1083/jcb.200606139