Research outputs
2026
Kirigami-Inspired Deployable Microneedle Robot With Enhanced Conformability for Targeted Oral Drug Delivery
Zhou, K., Sun, R., Zuo, Y., Peeler, D. J., Yeow, J., Xie, R., . . . Stevens, M. M. (2026). Kirigami-Inspired Deployable Microneedle Robot With Enhanced Conformability for Targeted Oral Drug Delivery. SMALL, 14 pages. doi:10.1002/smll.75632
Label-free biochemical imaging and time point analysis of neural organoids via deep learning-enhanced Raman microspectroscopy
Georgiev, D., Xie, R., Reumann, D., Zhao, X., Fernandez-Galiana, A., Barahona, M., & Stevens, M. M. (2026). Label-free biochemical imaging and time point analysis of neural organoids via deep learning-enhanced Raman microspectroscopy. SCIENCE ADVANCES, 12(33), 16 pages. doi:10.1126/sciadv.aec5080
Multistage microrobots with pH-responsive release of platelet membrane-coated nanoparticles
Sun, R., Kim, J., Leng, Y., Zuo, Y., Kim, J., Xie, R., . . . Stevens, M. M. (2026). Multistage microrobots with pH-responsive release of platelet membrane-coated nanoparticles. SCIENCE ADVANCES, 12(29), 13 pages. doi:10.1126/sciadv.aee6534
High-entropy nanozymes: a frontier toward next-generation high-performance nanozymes
He, M. -Q., Gong, Y., Wang, R., Liu, P., Fang, B., Li, Y., . . . Ai, Y. (2026). High-entropy nanozymes: a frontier toward next-generation high-performance nanozymes. MedMat, 3(1), 1-5. doi:10.1097/mm9.0000000000000042
An injectable soft implant for long-acting, reversible, ultra-stable release of therapeutics
When microfluidics meets pharmaceutical analysis
Ai, Y., Li, L., Xie, R., Wang, P., Guo, H., Ren, F., . . . Liang, Q. (2026). When microfluidics meets pharmaceutical analysis. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 194, 19 pages. doi:10.1016/j.trac.2025.118518
2025
Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis
Han, M., Lin, W., Cao, Y., Murray, P., Wilm, B., McWilliam, S. J., . . . Xie, R. (2025). Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis. ADVANCED HEALTHCARE MATERIALS, 14(31), 19 pages. doi:10.1002/adhm.202500550
35(+1) challenges in materials science being tackled by PIs under 35(ish) in 2025
Bismillah, A. N., Bismuto, A., Blakney, A., Callens, S., Calvino, C., Crespi, S., . . . Wells, C. (2025). 35(+1) challenges in materials science being tackled by PIs under 35(ish) in 2025. MATTER, 8(12), 7 pages. doi:10.1016/j.matt.2025.102565
MODELING MYOCARDIAL ISCHEMIA WITH VASCULARIZED HUMAN HEART-ON-A-CHIP TO ANALYZE NANOMEDICINE DELIVERY
Kim, J., Zhang, X., Wang, R., Najer, A., You, Q., Cammack-Najera, A., . . . M., M. (2025). MODELING MYOCARDIAL ISCHEMIA WITH VASCULARIZED HUMAN HEART-ON-A-CHIP TO ANALYZE NANOMEDICINE DELIVERY. In 2025 MicroTAS Book of Abstracts. Chemical and Biological Microsystems Society. doi:10.70477/biqh9706
Vascularized and Perfusable Human Heart-on-a-Chip Model Recapitulates Aspects of Myocardial Ischemia and Enables Analysis of Nanomedicine Delivery
Kim, J., Zhang, X., Wang, R., Najer, A., Lau, Q. Y., Cammack-Najera, A., . . . Stevens, M. M. (2025). Vascularized and Perfusable Human Heart-on-a-Chip Model Recapitulates Aspects of Myocardial Ischemia and Enables Analysis of Nanomedicine Delivery. ADVANCED MATERIALS, 37(41), 16 pages. doi:10.1002/adma.202418909
CETN3 deficiency induces microcephaly by disrupting neural stem/progenitor cell fate through impaired centrosome assembly and RNA splicing
Xu, J., Mao, X., Liu, Z., Jiang, N., Wong, X. E., Liu, D., . . . Bian, S. (2025). CETN3 deficiency induces microcephaly by disrupting neural stem/progenitor cell fate through impaired centrosome assembly and RNA splicing. EMBO MOLECULAR MEDICINE, 17(10), 2735-2761. doi:10.1038/s44321-025-00302-7
Label-free biochemical imaging and timepoint analysis of neural organoids via deep learning-enhanced Raman microspectroscopy
Permanent magnetic droplet-derived microrobots
Cao, Y., Xie, R., Schonhofer, P. W. A., Burdis, R., Wang, R., Sun, R., . . . Stevens, M. M. (2025). Permanent magnetic droplet-derived microrobots. SCIENCE ADVANCES, 11(28), 16 pages. doi:10.1126/sciadv.adw3172
Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity
Chambers, S. E. J., Guduric-Fuchs, J., Pedrini, E., Bertelli, P. M., Charoensuk, C., Peixoto, E., . . . Medina, R. J. (2025). Human endothelial colony forming cells (ECFCs) require endothelial protein C receptor (EPCR) for cell cycle progression and angiogenic activity. ANGIOGENESIS, 28(3), 17 pages. doi:10.1007/s10456-025-09982-8
2024
Hyperspectral unmixing for Raman spectroscopy via physics-constrained autoencoders
Georgiev, D., Fernandez-Galiana, A., Pedersen, S. V., Papadopoulos, G., Xie, R., Stevens, M. M., & Barahona, M. (2024). Hyperspectral unmixing for Raman spectroscopy via physics-constrained autoencoders. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 121(45), 11 pages. doi:10.1073/pnas.2407439121
A Facile Method to Quantify Synthetic Peptide Concentrations on Biomaterials
Wojciechowski, J. P., Benge, T., Chen, K., Echalier, C., Xie, R., & Stevens, M. M. (2024). A Facile Method to Quantify Synthetic Peptide Concentrations on Biomaterials. ACS APPLIED MATERIALS & INTERFACES, 16(37), 49880-49888. doi:10.1021/acsami.4c07164
Engineered Microfibers for Tissue Engineering
Su, R., Ai, Y., Wang, J., Wu, L., Sun, H., Ding, M., . . . Liang, Q. (2024). Engineered Microfibers for Tissue Engineering. ACS APPLIED BIO MATERIALS, 7(9), 5823-5840. doi:10.1021/acsabm.4c00615
RamanSPy: An Open-Source Python Package for Integrative Raman Spectroscopy Data Analysis
Georgiev, D., Pedersen, S. V., Xie, R., Fernandez-Galiana, A., Stevens, M. M., & Barahona, M. (2024). RamanSPy: An Open-Source Python Package for Integrative Raman Spectroscopy Data Analysis. ANALYTICAL CHEMISTRY, 96(21), 8492-8500. doi:10.1021/acs.analchem.4c00383
Hyperspectral unmixing for Raman spectroscopy via physics-constrained autoencoders
Magnetically driven formation of 3D freestanding soft bioscaffolds.
Xie, R., Cao, Y., Sun, R., Wang, R., Morgan, A., Kim, J., . . . Stevens, M. M. (2024). Magnetically driven formation of 3D freestanding soft bioscaffolds.. Science advances, 10(5), eadl1549. doi:10.1126/sciadv.adl1549
2023
Microfibrous Scaffolds Guide Stem Cell Lumenogenesis and Brain Organoid Engineering
Ritzau-Reid, K. I., Callens, S. J. P., Xie, R., Cihova, M., Reumann, D., Grigsby, C. L., . . . Stevens, M. M. (2023). Microfibrous Scaffolds Guide Stem Cell Lumenogenesis and Brain Organoid Engineering. ADVANCED MATERIALS, 35(41), 14 pages. doi:10.1002/adma.202300305
RamanSPy: An open-source Python package for integrative Raman spectroscopy data analysis
RamanSPy: An open-source Python package for integrative Raman spectroscopy data analysis
RamanSPy: An open-source Python package for integrative Raman spectroscopy data analysis
Assembly of Fillable Microrobotic Systems by Microfluidic Loading with Dip Sealing
Sun, R., Song, X., Zhou, K., Zuo, Y., Wang, R., Rifaie-Graham, O., . . . Stevens, M. M. (2023). Assembly of Fillable Microrobotic Systems by Microfluidic Loading with Dip Sealing. ADVANCED MATERIALS, 35(13), 14 pages. doi:10.1002/adma.202207791
Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models
Wu, L., Ai, Y., Xie, R., Xiong, J., Wang, Y., & Liang, Q. (2023). Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models. LAB ON A CHIP, 23(5), 1192-1212. doi:10.1039/d2lc00804a
2022
Puffball-Inspired Microrobotic Systems with Robust Payload, Strong Protection, and Targeted Locomotion for On-Demand Drug Delivery
Song, X., Sun, R., Wang, R., Zhou, K., Xie, R., Lin, J., . . . Stevens, M. M. (2022). Puffball-Inspired Microrobotic Systems with Robust Payload, Strong Protection, and Targeted Locomotion for On-Demand Drug Delivery. ADVANCED MATERIALS, 34(43), 14 pages. doi:10.1002/adma.202204791
Fabrication of Biomaterials and Biostructures Based On Microfluidic Manipulation
Zheng, W., Xie, R., Liang, X., & Liang, Q. (2022). Fabrication of Biomaterials and Biostructures Based On Microfluidic Manipulation. SMALL, 18(16), 25 pages. doi:10.1002/smll.202105867
2021
Nitrite-responsive hydrogel for long-term and smart control of cyanobacteria bloom
Xiong, J., Xie, R., Zhang, H., Gao, J., Wang, J., & Liang, Q. (2021). Nitrite-responsive hydrogel for long-term and smart control of cyanobacteria bloom. JOURNAL OF HAZARDOUS MATERIALS, 411, 9 pages. doi:10.1016/j.jhazmat.2021.125150
Composable microfluidic spinning platforms for facile production of biomimetic perfusable hydrogel microtubes
Xie, R., Liang, Z., Ai, Y., Zheng, W., Xiong, J., Xu, P., . . . Liang, Q. (2021). Composable microfluidic spinning platforms for facile production of biomimetic perfusable hydrogel microtubes. NATURE PROTOCOLS, 16(2), 35 pages. doi:10.1038/s41596-020-00442-9
2020
Nitrite-Responsive Hydrogel: Smart Drug Release Depending on the Severity of the Nitric Oxide-Related Disease
Xiong, J., Xie, R., Wang, Y., Wang, C., Ai, Y., Zheng, W., . . . Liang, Q. (2020). Nitrite-Responsive Hydrogel: Smart Drug Release Depending on the Severity of the Nitric Oxide-Related Disease. ACS APPLIED MATERIALS & INTERFACES, 12(46), 51185-51197. doi:10.1021/acsami.0c13688
h-FIBER: Microfluidic Topographical Hollow Fiber for Studies of Glomerular Filtration Barrier
Xie, R., Korolj, A., Liu, C., Song, X., Lu, R. X. Z., Zhang, B., . . . Radisic, M. (2020). h-FIBER: Microfluidic Topographical Hollow Fiber for Studies of Glomerular Filtration Barrier. ACS CENTRAL SCIENCE, 6(6), 903-912. doi:10.1021/acscentsci.9b01097
Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues
Xie, R., Zheng, W., Guan, L., Ai, Y., & Liang, Q. (2020). Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues. SMALL, 16(15), 17 pages. doi:10.1002/smll.201902838
Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells
Ai, Y., Xie, R., Xiong, J., & Liang, Q. (2020). Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells. SMALL, 16(9), 24 pages. doi:10.1002/smll.201903940
2019
Recent progress in lab-on-a-chip for pharmaceutical analysis and pharmacological/toxicological test
Ai, Y., Zhang, F., Wang, C., Xie, R., & Liang, Q. (2019). Recent progress in lab-on-a-chip for pharmaceutical analysis and pharmacological/toxicological test. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 117, 215-230. doi:10.1016/j.trac.2019.06.026
Microfluidic fabrication of water-in-water droplets encapsulated in hydrogel microfibers
Liu, C., Zheng, W., Xie, R., Liu, Y., Liang, Z., Luo, G., . . . Liang, Q. (2019). Microfluidic fabrication of water-in-water droplets encapsulated in hydrogel microfibers. CHINESE CHEMICAL LETTERS, 30(2), 457-460. doi:10.1016/j.cclet.2018.09.010
Hydrogel microfibers with perfusable folded channels for tissue constructs with folded morphology (vol 8, pg 23475, 2018)
Liu, Y., Xu, P., Liang, Z., Xie, R., Ding, M., Liu, H., & Liang, Q. (2019). Hydrogel microfibers with perfusable folded channels for tissue constructs with folded morphology (vol 8, pg 23475, 2018). RSC ADVANCES, 9(19), 10625. doi:10.1039/c9ra90025j
2018
Microfabrication of AngioChip, a biodegradable polymer scaffold with microfluidic vasculature
Zhang, B., Lai, B. F. L., Xie, R., Huyer, L. D., Montgomery, M., & Radisic, M. (2018). Microfabrication of AngioChip, a biodegradable polymer scaffold with microfluidic vasculature. NATURE PROTOCOLS, 13(8), 1793-1813. doi:10.1038/s41596-018-0015-8
Necklace-Like Microfibers with Variable Knots and Perfusable Channels Fabricated by an Oil-Free Microfluidic Spinning Process
Xie, R., Xu, P., Liu, Y., Li, L., Luo, G., Ding, M., & Liang, Q. (2018). Necklace-Like Microfibers with Variable Knots and Perfusable Channels Fabricated by an Oil-Free Microfluidic Spinning Process. ADVANCED MATERIALS, 30(14), 6 pages. doi:10.1002/adma.201705082
Hydrogel microfibers with perfusable folded channels for tissue constructs with folded morphology
Liu, Y., Xu, P., Liang, Z., Xie, R., Ding, M., Liu, H., & Liang, Q. (2018). Hydrogel microfibers with perfusable folded channels for tissue constructs with folded morphology. RSC ADVANCES, 8(42), 23475-23480. doi:10.1039/c8ra04192j
2017
Bioinspired Microfibers with Embedded Perfusable Helical Channels
Xu, P., Xie, R., Liu, Y., Luo, G., Ding, M., & Liang, Q. (2017). Bioinspired Microfibers with Embedded Perfusable Helical Channels. ADVANCED MATERIALS, 29(34), 7 pages. doi:10.1002/adma.201701664
Microfibers: Bioinspired Microfibers with Embedded Perfusable Helical Channels (Adv. Mater. 34/2017)
Xu, P., Xie, R., Liu, Y., Luo, G., Ding, M., & Liang, Q. (2017). Microfibers: Bioinspired Microfibers with Embedded Perfusable Helical Channels (Adv. Mater. 34/2017). Advanced Materials, 29(34). doi:10.1002/adma.201770243