Research outputs
Selected research outputs
- Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease (Journal article - 2020)
- Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling (Journal article - 2021)
- Probe Confined Dynamic Mapping for G Protein-Coupled Receptor Allosteric Site Prediction (Journal article - 2021)
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion (Journal article - 2023)
- A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR (Journal article - 2024)
- Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists (Journal article - 2024)
- Structural analysis of the human C5a-C5aR1 complex using cryo-electron microscopy. (Journal article - 2024)
- Elucidating the Activation Mechanism of the Proton-sensing GPR68 Receptor (Journal article - 2024)
2026
Structural and dynamic insights into agonist recognition and function of the thromboxane A2 receptor
Krawinski, P., Matzov, D., Ryder, A., Lal, K., Karlov, D. S., Chalhoub, G., . . . Shalev-Benami, M. (2026). Structural and dynamic insights into agonist recognition and function of the thromboxane A2 receptor. Nature Communications, 17(1). doi:10.1038/s41467-026-69844-9
Corrigendum to “Histamine H1 receptor: a potential therapeutic target for pancreatic ductal adenocarcinoma”
Salmerón, C., Bort, E. T., Sriram, K., Javadi-Paydar, M., Smitham, J. E., Pham, K., . . . Insel, P. A. (2026). Corrigendum to “Histamine H1 receptor: a potential therapeutic target for pancreatic ductal adenocarcinoma”. The Journal of Pharmacology and Experimental Therapeutics, 393(4), 104305. doi:10.1016/j.jpet.2026.104305
β-Arrestins and disease-linked variants: opportunities for targeted modulation
Hasinger, S., Fraunhofer, A., Hermes, J., McCormick, P. J., & Gruber, C. W. (2026). β-Arrestins and disease-linked variants: opportunities for targeted modulation. Trends in Pharmacological Sciences, 47(3), 290-308. doi:10.1016/j.tips.2026.01.004
A network-based atlas of human skeletal muscle aging
2025
MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor
Sohail, I., Laurin, S. -A., Kleinau, G., Chunilal, V., Morton, A., Brenlla, A., . . . Biebermann, H. (2025). MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor. Nature Communications, 16(1). doi:10.1038/s41467-025-63988-w
Metabolic dysfunction over a life course key to healthy ageing inequality
Littlewood, K., Gegic, J., Hickman, M., Henson, R. C. J., Bishop, J. R., Kershaw, T., . . . Xu, R. (2025). Metabolic dysfunction over a life course key to healthy ageing inequality. Aging Clinical and Experimental Research, 37(1). doi:10.1007/s40520-025-03034-3
Biodiversity2Drugs—Renaissance of exploring nature‐derived peptides for GPCR ligand discovery
Gruber, C. W., Beets, I., Boudreault, P., Bolzani, V. D. S., Carlsson, J., Fernandes, P. A., . . . Undheim, E. A. B. (2025). Biodiversity2Drugs—Renaissance of exploring nature‐derived peptides for GPCR ligand discovery. British Journal of Pharmacology, 182(16), 3691-3694. doi:10.1111/bph.70072
Histamine H1 Receptor: A potential therapeutic target for pancreatic ductal adenocarcinoma
Salmerón, C., Tomás Bort, E., Sriram, K., Javadi-Paydar, M., Smitham, J. E., Pham, K., . . . Insel, P. A. (2025). Histamine H1 Receptor: A potential therapeutic target for pancreatic ductal adenocarcinoma. The Journal of Pharmacology and Experimental Therapeutics, 392(5), 103573. doi:10.1016/j.jpet.2025.103573
Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM
Chen, H. -H., Highland, H. M., Frankel, E. G., Scartozzi, A. C., Zhang, X., Roshani, R., . . . Below, J. E. (2025). Multiomics reveal key inflammatory drivers of severe obesity: IL4R, LILRA5, and OSM. Cell Genomics, 5(3), 100784. doi:10.1016/j.xgen.2025.100784
Identification of a Cannabinoid Receptor 2 Allosteric Site Using Computational Modeling and Pharmacological Analysis
Farooq, Z., Delre, P., Iliadis, S., Mangiatordi, G. F., Contino, M., Howell, L. A., & McCormick, P. J. (2025). Identification of a Cannabinoid Receptor 2 Allosteric Site Using Computational Modeling and Pharmacological Analysis. ACS Pharmacology & Translational Science. doi:10.1021/acsptsci.4c00547
Pancreatic Ductal Adenocarcinoma, β-blockers, and Antihistamines: A Clinical Trial Is Needed
Baker, J. G., Sloan, E. K., Pfleger, K. D. G., McCormick, P. J., Salmerón, C., & Insel, P. A. (2025). Pancreatic Ductal Adenocarcinoma, β-blockers, and Antihistamines: A Clinical Trial Is Needed. Function, 6(1). doi:10.1093/function/zqae050
2024
A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR
Peri, L., Matzov, D., Huxley, D. R., Rainish, A., Fierro, F., Sapir, L., . . . Shalev-Benami, M. (2024). A bitter anti-inflammatory drug binds at two distinct sites of a human bitter taste GPCR. Nature Communications, 15(1). doi:10.1038/s41467-024-54157-6
Elucidating the Activation Mechanism of the Proton-sensing GPR68 Receptor
Matsingos, C., Howell, L. A., McCormick, P. J., & Fornili, A. (2024). Elucidating the Activation Mechanism of the Proton-sensing GPR68 Receptor. Journal of Molecular Biology, 436(16), 168688. doi:10.1016/j.jmb.2024.168688
Structural analysis of the human C5a-C5aR1 complex using cryo-electron microscopy.
Yang, T., Li, J., Cheng, X., Lu, Q., Farooq, Z., Fu, Y., . . . Zhang, J. (2024). Structural analysis of the human C5a-C5aR1 complex using cryo-electron microscopy.. Journal of structural biology, 108117. doi:10.1016/j.jsb.2024.108117
Correction to: A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes
Cristóvão-Ferreira, S., Navarro, G., Brugarolas, M., Pérez-Capote, K., Vaz, S. H., Fattorini, G., . . . Sebastião, A. M. (2024). Correction to: A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes. Purinergic Signalling, 20(3), 315-316. doi:10.1007/s11302-024-10012-3
Cryo-EM structure of human HCN3 channel and its regulation by cAMP
Yu, B., Lu, Q., Li, J., Cheng, X., Hu, H., Li, Y., . . . Zhang, J. (2024). Cryo-EM structure of human HCN3 channel and its regulation by cAMP. Journal of Biological Chemistry, 300(6), 107288. doi:10.1016/j.jbc.2024.107288
Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists
Kosar, M., Sarott, R. C., Sykes, D. A., Viray, A. E. G., Vitale, R. M., Tomašević, N., . . . Carreira, E. M. (2024). Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists. ACS Central Science, 10(5), 956-968. doi:10.1021/acscentsci.3c01461
MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor
Intracellular binding pocket revealed in the human bitter taste receptor TAS2R14
A potent neutralizing nanobody targeting a unique epitope on the receptor-binding domain of SARS-CoV-2 spike protein
Zhang, Y., Wang, D., Xiang, Q., Hu, X., Zhang, Y., Wu, L., . . . Li, J. (2024). A potent neutralizing nanobody targeting a unique epitope on the receptor-binding domain of SARS-CoV-2 spike protein. Virology, 589, 109925. doi:10.1016/j.virol.2023.109925
2023
Elucidating the activation mechanism of the proton-sensing GPR68 receptor
Gain-of-function mutation F278C in MC2R results in reduced beta-1-arrestin recruitment and increased cAMP implicating impairment of S280 phosphorylation
Popat, D., Xu, R., McCormick, P., & Chan, L. (2023). Gain-of-function mutation F278C in MC2R results in reduced beta-1-arrestin recruitment and increased cAMP implicating impairment of S280 phosphorylation. Endocrine Abstracts. doi:10.1530/endoabs.94.oc5.2
Luteinising hormone receptor signalling is reliant on formation of distinct multi-receptor complexes
Walker, A., Hopkins, T., Howell, L., Farooq, Z., McCormick, P., Jonas, K., & Hanyaloglu, A. (2023). Luteinising hormone receptor signalling is reliant on formation of distinct multi-receptor complexes. Endocrine Abstracts. doi:10.1530/endoabs.94.oc4.5
Flipping the GPCR Switch: Structure–Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists
Development of Melanocortin 4 Receptor Agonists by Exploiting Animal-Derived Macrocyclic, Disulfide-Rich Peptide Scaffolds
Muratspahić, E., Aslanoglou, D., White, A. M., Draxler, C., Kozisek, X., Farooq, Z., . . . Gruber, C. W. (2023). Development of Melanocortin 4 Receptor Agonists by Exploiting Animal-Derived Macrocyclic, Disulfide-Rich Peptide Scaffolds. ACS Pharmacology & Translational Science, 6(10), 1373-1381. doi:10.1021/acsptsci.3c00090
The Batten disease protein CLN3 is important for stress granules dynamics and translational activity
Relton, E. L., Roth, N. J., Yasa, S., Kaleem, A., Hermey, G., Minnis, C. J., . . . Locker, N. (2023). The Batten disease protein CLN3 is important for stress granules dynamics and translational activity. Journal of Biological Chemistry, 299(5), 104649. doi:10.1016/j.jbc.2023.104649
Characterization of dominant-negative growth hormone receptor variants reveals a potential therapeutic target for short stature
Andrews, A., Cottrell, E., Maharaj, A., Ladha, T., Williams, J., Schilbach, K., . . . Storr, H. L. (2023). Characterization of dominant-negative growth hormone receptor variants reveals a potential therapeutic target for short stature. European Journal of Endocrinology, 188(4), 353-365. doi:10.1093/ejendo/lvad039
Wnt signalling in the articular cartilage: A matter of balance
Gill, A. K., McCormick, P. J., Sochart, D., & Nalesso, G. (2023). Wnt signalling in the articular cartilage: A matter of balance. International Journal of Experimental Pathology, 104(2), 56-63. doi:10.1111/iep.12472
Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
Tomas Bort, E., Joseph, M. D., Wang, Q., Carter, E. P., Roth, N. J., Gibson, J., . . . Grose, R. P. (2023). Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion. eLife, 12. doi:10.7554/elife.86971
Understanding Probe Dependency of an Allosteric Site at the Dopamine D2 Receptor
Abstract P322: Transcriptomic Analysis of Severe Obesity Identifies Novel Genes in Hispanic/Latino Populations With a High Burden of Disease
Sharma, P., Chen, H. -H., Zhu, W., Polikowsky, H. G., Mccormick, P., Karastergiou, K., . . . Below, J. (2023). Abstract P322: Transcriptomic Analysis of Severe Obesity Identifies Novel Genes in Hispanic/Latino Populations With a High Burden of Disease. Circulation, 147(Suppl_1). doi:10.1161/circ.147.suppl_1.p322
2022
Extracellular ATP drives pancreatic cancer cell invasion via purinergic receptor-integrin interactions
Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor
Hu, X., Lin, C., Xu, Q., Zhou, X., Zeng, P., McCormick, P. J., . . . Zhang, J. (2022). Structural Basis for the Inhibition of Coronaviral Main Proteases by a Benzothiazole-Based Inhibitor. Viruses, 14(9), 2075. doi:10.3390/v14092075
Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814
Li, J., Lin, C., Zhou, X., Zhong, F., Zeng, P., McCormick, P. J., . . . Zhang, J. (2022). Structural Basis of Main Proteases of Coronavirus Bound to Drug Candidate PF-07304814. Journal of Molecular Biology, 434(16), 167706. doi:10.1016/j.jmb.2022.167706
Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine
Aslanoglou, D., Bertera, S., Friggeri, L., Sánchez-Soto, M., Lee, J., Xue, X., . . . Freyberg, Z. (2022). Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine. iScience, 25(8), 104771. doi:10.1016/j.isci.2022.104771
Probing GPCR Dimerization Using Peptides
Farooq, Z., Howell, L. A., & McCormick, P. J. (2022). Probing GPCR Dimerization Using Peptides. Frontiers in Endocrinology, 13. doi:10.3389/fendo.2022.843770
The Batten disease protein CLN3 is important for stress granules dynamics and translational activity
Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe
Gazzi, T., Brennecke, B., Atz, K., Korn, C., Sykes, D., Forn-Cuni, G., . . . Nazaré, M. (2022). Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe. Chemical Science, 13(19), 5539-5545. doi:10.1039/d1sc06659e
Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332
Li, J., Lin, C., Zhou, X., Zhong, F., Zeng, P., Yang, Y., . . . Zhang, J. (2022). Structural Basis of the Main Proteases of Coronavirus Bound to Drug Candidate PF-07321332. Journal of Virology, 96(8). doi:10.1128/jvi.02013-21
Cryo-EM structure of mouse TRPML2 in lipid nanodiscs
Song, X., Li, J., Tian, M., Zhu, H., Hu, X., Zhang, Y., . . . Zhang, J. (2022). Cryo-EM structure of mouse TRPML2 in lipid nanodiscs. Journal of Biological Chemistry, 298(2), 101487. doi:10.1016/j.jbc.2021.101487
Palmitoylation and G-protein coupled receptors
Palmitoylation and G-protein coupled receptors (2022). In Progress in Molecular Biology and Translational Science (pp. 195-211). Elsevier. doi:10.1016/bs.pmbts.2022.09.002
Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus
Zhang, Y., Gao, H., Hu, X., Wang, Q., Zhong, F., Zhou, X., . . . Li, J. (2022). Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus. Journal of Virology, 96(1). doi:10.1128/jvi.01253-21
2021
Probe Confined Dynamic Mapping for G Protein-Coupled Receptor Allosteric Site Prediction
Ciancetta, A., Gill, A. K., Ding, T., Karlov, D. S., Chalhoub, G., McCormick, P. J., & Tikhonova, I. G. (2021). Probe Confined Dynamic Mapping for G Protein-Coupled Receptor Allosteric Site Prediction. ACS Central Science, 7(11), 1847-1862. doi:10.1021/acscentsci.1c00802
Structural basis of main proteases of coronavirus bound to drug candidate PF-07321332
Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization
Joseph, M. D., Tomas Bort, E., Grose, R. P., McCormick, P. J., & Simoncelli, S. (2021). Quantitative Super-Resolution Imaging for the Analysis of GPCR Oligomerization. Biomolecules, 11(10), 1503. doi:10.3390/biom11101503
Identification of BiP as a CB<sub>1</sub> Receptor-Interacting Protein That Fine-Tunes Cannabinoid Signaling in the Mouse Brain
Costas-Insua, C., Moreno, E., Maroto, I. B., Ruiz-Calvo, A., Bajo-Grañeras, R., Martín-Gutiérrez, D., . . . Guzmán, M. (2021). Identification of BiP as a CB<sub>1</sub> Receptor-Interacting Protein That Fine-Tunes Cannabinoid Signaling in the Mouse Brain. The Journal of Neuroscience, 41(38), 7924-7941. doi:10.1523/jneurosci.0821-21.2021
Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signalling
H, I., O, D., F, F., V, C., AK, G., NJ, R., . . . M, S. -B. (2021). Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signalling. Yearbook of Paediatric Endocrinology. doi:10.1530/ey.18.11.2
To eat or not to eat: cryo-EM structure of melanocortin receptor 4 reveals mechanism of a 'hunger switch' initiating satiety signalling
Degtjarik, O., Israeli, H., Chan, L. F., Ben-Zvi, D., Niv, M. Y., McCormick, P. J., & Shalev-Benami, M. (2021). To eat or not to eat: cryo-EM structure of melanocortin receptor 4 reveals mechanism of a 'hunger switch' initiating satiety signalling. In Acta Crystallographica Section A Foundations and Advances Vol. 77 (pp. C480). International Union of Crystallography (IUCr). doi:10.1107/s0108767321092060
Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling
Israeli, H., Degtjarik, O., Fierro, F., Chunilal, V., Gill, A. K., Roth, N. J., . . . Shalev-Benami, M. (2021). Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling. Science, 372(6544), 808-814. doi:10.1126/science.abf7958
Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode
Li, J., Zhou, X., Zhang, Y., Zhong, F., Lin, C., McCormick, P. J., . . . Zhang, J. (2021). Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode. Science Bulletin, 66(7), 661-663. doi:10.1016/j.scib.2020.10.018
Structure of SARS-CoV-2 main protease in the apo state
Zhou, X., Zhong, F., Lin, C., Hu, X., Zhang, Y., Xiong, B., . . . Zhang, J. (2021). Structure of SARS-CoV-2 main protease in the apo state. Science China Life Sciences, 64(4), 656-659. doi:10.1007/s11427-020-1791-3
Novel dominant negative GH receptor variants provide important insights into GH receptor physiology
Andrews, A., Cottrell, E., Maharaj, A., Ladha, T., Williams, J., Metherell, L. A., . . . Storr, H. L. (2021). Novel dominant negative GH receptor variants provide important insights into GH receptor physiology. In Endocrine Abstracts. Bioscientifica. doi:10.1530/endoabs.78.oc6.1
2020
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells
Sarott, R. C., Westphal, M. V., Pfaff, P., Korn, C., Sykes, D. A., Gazzi, T., . . . Carreira, E. M. (2020). Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells. Journal of the American Chemical Society, 142(40), 16953-16964. doi:10.1021/jacs.0c05587
Crystal structure of SARS-CoV-2 main protease in complex with a Chinese herb inhibitor shikonin
Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease
Moreno-Delgado, D., Puigdellívol, M., Moreno, E., Rodríguez-Ruiz, M., Botta, J., Gasperini, P., . . . McCormick, P. J. (2020). Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease. eLife, 9. doi:10.7554/elife.51093
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells
Development of High-Specificity Fluorescent Probes to Enable Cannabinoid Type 2 Receptor Studies in Living Cells
Editorial: The Canonical and Non-Canonical Endocannabinoid System as a Target in Cancer and Acute and Chronic Pain
Contino, M., & McCormick, P. J. (2020). Editorial: The Canonical and Non-Canonical Endocannabinoid System as a Target in Cancer and Acute and Chronic Pain. Frontiers in Pharmacology, 11. doi:10.3389/fphar.2020.00312
Is the sigma-1 receptor a potential pharmacological target for cardiac pathologies? A systematic review
Lewis, R., Li, J., McCormick, P. J., L-H Huang, C., & Jeevaratnam, K. (2020). Is the sigma-1 receptor a potential pharmacological target for cardiac pathologies? A systematic review. IJC Heart & Vasculature, 26, 100449. doi:10.1016/j.ijcha.2019.100449
Continuing challenges in targeting oligomeric GPCR-based drugs
Continuing challenges in targeting oligomeric GPCR-based drugs (2020). In Progress in Molecular Biology and Translational Science (pp. 213-245). Elsevier. doi:10.1016/bs.pmbts.2019.11.009
2019
Site‐Specific Encoding of Photoactivity in Antibodies Enables Light‐Mediated Antibody–Antigen Binding on Live Cells
Bridge, T., Shaikh, S. A., Thomas, P., Botta, J., McCormick, P. J., & Sachdeva, A. (2019). Site‐Specific Encoding of Photoactivity in Antibodies Enables Light‐Mediated Antibody–Antigen Binding on Live Cells. Angewandte Chemie International Edition, 58(50), 17986-17993. doi:10.1002/anie.201908655
Site‐Specific Encoding of Photoactivity in Antibodies Enables Light‐Mediated Antibody–Antigen Binding on Live Cells
Bridge, T., Shaikh, S. A., Thomas, P., Botta, J., McCormick, P. J., & Sachdeva, A. (2019). Site‐Specific Encoding of Photoactivity in Antibodies Enables Light‐Mediated Antibody–Antigen Binding on Live Cells. Angewandte Chemie, 131(50), 18154-18161. doi:10.1002/ange.201908655
Drug Derived Fluorescent Probes for the Specific Visualization of Cannabinoid Type 2 Receptor - A Toolbox Approach
Highly Specific, Fluorescent Cannabinoid Type 2 Receptor Probes Enable Applications in Microscopy, Flow Cytometry and FRET-based Binding Assays
Modulation of dopamine D <sub>1</sub> receptors via histamine H <sub>3</sub> receptors is a novel therapeutic target for Huntington’s disease
Design and development of stapled transmembrane peptides that disrupt the activity of G-protein–coupled receptor oligomers
Botta, J., Bibic, L., Killoran, P., McCormick, P. J., & Howell, L. A. (2019). Design and development of stapled transmembrane peptides that disrupt the activity of G-protein–coupled receptor oligomers. Journal of Biological Chemistry, 294(45), 16587-16603. doi:10.1074/jbc.ra119.009160
Therapeutic targeting of HER2–CB <sub>2</sub> R heteromers in HER2-positive breast cancer
Blasco-Benito, S., Moreno, E., Seijo-Vila, M., Tundidor, I., Andradas, C., Caffarel, M. M., . . . Sánchez, C. (2019). Therapeutic targeting of HER2–CB <sub>2</sub> R heteromers in HER2-positive breast cancer. Proceedings of the National Academy of Sciences, 116(9), 3863-3872. doi:10.1073/pnas.1815034116
Correction for Blasco-Benito et al., Therapeutic targeting of HER2–CB2R heteromers in HER2-positive breast cancer
Correction for Blasco-Benito et al., Therapeutic targeting of HER2–CB2R heteromers in HER2-positive breast cancer (2019). Proceedings of the National Academy of Sciences, 116(13), 6505. doi:10.1073/pnas.1903209116
2018
Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences
Aringhieri, S., Carli, M., Kolachalam, S., Verdesca, V., Cini, E., Rossi, M., . . . Scarselli, M. (2018). Molecular targets of atypical antipsychotics: From mechanism of action to clinical differences. Pharmacology & Therapeutics, 192, 20-41. doi:10.1016/j.pharmthera.2018.06.012
Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum
Moreno, E., Chiarlone, A., Medrano, M., Puigdellívol, M., Bibic, L., Howell, L. A., . . . Guzmán, M. (2018). Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum. Neuropsychopharmacology, 43(5), 964-977. doi:10.1038/npp.2017.12
Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain
Navarro, G., Cordomí, A., Brugarolas, M., Moreno, E., Aguinaga, D., Pérez-Benito, L., . . . Franco, R. (2018). Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain. BMC Biology, 16(1). doi:10.1186/s12915-018-0491-x
2017
A Positive Allosteric Modulator of the Serotonin 5-HT<sub>2C</sub>Receptor for Obesity
García-Cárceles, J., Decara, J. M., Vázquez-Villa, H., Rodríguez, R., Codesido, E., Cruces, J., . . . López-Rodríguez, M. L. (2017). A Positive Allosteric Modulator of the Serotonin 5-HT<sub>2C</sub>Receptor for Obesity. Journal of Medicinal Chemistry, 60(23), 9575-9584. doi:10.1021/acs.jmedchem.7b00994
In vivo monitoring of the recruitment and activation of AP-1 by Arf1
Sauvageau, E., McCormick, P. J., & Lefrancois, S. (2017). In vivo monitoring of the recruitment and activation of AP-1 by Arf1. Scientific Reports, 7(1). doi:10.1038/s41598-017-07493-1
Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor
Fahradpour, M., Keov, P., Tognola, C., Perez-Santamarina, E., McCormick, P. J., Ghassempour, A., & Gruber, C. W. (2017). Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor. Frontiers in Pharmacology, 8. doi:10.3389/fphar.2017.00616
Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer’s Disease
Rodríguez-Ruiz, M., Moreno, E., Moreno-Delgado, D., Navarro, G., Mallol, J., Cortés, A., . . . Franco, R. (2017). Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer’s Disease. Molecular Neurobiology, 54(6), 4537-4550. doi:10.1007/s12035-016-9995-y
A new serotonin 5-HT6 receptor antagonist with procognitive activity – Importance of a halogen bond interaction to stabilize the binding
González-Vera, J. A., Medina, R. A., Martín-Fontecha, M., Gonzalez, A., de la Fuente, T., Vázquez-Villa, H., . . . López-Rodríguez, M. L. (2017). A new serotonin 5-HT6 receptor antagonist with procognitive activity – Importance of a halogen bond interaction to stabilize the binding. Scientific Reports, 7(1). doi:10.1038/srep41293
Erratum
Erratum (2017). International Journal of Neuropsychopharmacology, 20(1), 94. doi:10.1093/ijnp/pyw104
Heteromers Form Novel Signaling Complexes
McCormick, P. J., & Botta, J. (2017). Heteromers Form Novel Signaling Complexes. In G-Protein-Coupled Receptor Dimers (pp. 467-475). Springer International Publishing. doi:10.1007/978-3-319-60174-8_19
Long-Lasting Impairment of mGluR<sub>5</sub>-Activated Intracellular Pathways in the Striatum After Withdrawal of Cocaine Self-Administration
Hoffmann, H. M., Crouzin, N., Moreno, E., Raivio, N., Fuentes, S., McCormick, P. J., . . . Vignes, M. (2016). Long-Lasting Impairment of mGluR<sub>5</sub>-Activated Intracellular Pathways in the Striatum After Withdrawal of Cocaine Self-Administration. International Journal of Neuropsychopharmacology, pyw086. doi:10.1093/ijnp/pyw086
2016
The insulin‐like growth factor I receptor regulates glucose transport by astrocytes
Hernandez‐Garzón, E., Fernandez, A. M., Perez‐Alvarez, A., Genis, L., Bascuñana, P., Fernandez de la Rosa, R., . . . Torres Aleman, I. (2016). The insulin‐like growth factor I receptor regulates glucose transport by astrocytes. Glia, 64(11), 1962-1971. doi:10.1002/glia.23035
Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure
Busnelli, M., Kleinau, G., Muttenthaler, M., Stoev, S., Manning, M., Bibic, L., . . . Chini, B. (2016). Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure. Journal of Medicinal Chemistry, 59(15), 7152-7166. doi:10.1021/acs.jmedchem.6b00564
Abstract 3288: The chemokine receptor CXCR4 and the cannabinoid receptor CB2R form heterodimers in non-Hodgkin lymphoma (NHL) and solid tumors leading to functional crosstalk
Guerrero, M., Griera, R., Perez, M., Roué, G., Bosch, J., McCormick, P. J., . . . Perez-Galan, P. (2016). Abstract 3288: The chemokine receptor CXCR4 and the cannabinoid receptor CB2R form heterodimers in non-Hodgkin lymphoma (NHL) and solid tumors leading to functional crosstalk. In Cancer Research Vol. 76 (pp. 3288). American Association for Cancer Research (AACR). doi:10.1158/1538-7445.am2016-3288
A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons
Navarro, G., Aguinaga, D., Angelats, E., Medrano, M., Moreno, E., Mallol, J., . . . Ferré, S. (2016). A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons. Journal of Biological Chemistry, 291(25), 13048-13062. doi:10.1074/jbc.m116.715144
Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs
Navarro, G., Cordomí, A., Zelman-Femiak, M., Brugarolas, M., Moreno, E., Aguinaga, D., . . . Franco, R. (2016). Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs. BMC Biology, 14(1). doi:10.1186/s12915-016-0247-4
Revealing G‐protein‐coupled receptor oligomerization at the single‐molecule level through a nanoscopic lens: methods, dynamics and biological function
Scarselli, M., Annibale, P., McCormick, P. J., Kolachalam, S., Aringhieri, S., Radenovic, A., . . . Maggio, R. (2016). Revealing G‐protein‐coupled receptor oligomerization at the single‐molecule level through a nanoscopic lens: methods, dynamics and biological function. The FEBS Journal, 283(7), 1197-1217. doi:10.1111/febs.13577
Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1
Naval-Macabuhay, I., Casanova, V., Navarro, G., García, F., León, A., Miralles, L., . . . Climent, N. (2016). Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1. Journal of Leukocyte Biology, 99(2), 349-359. doi:10.1189/jlb.3a1214-580rr
2015
Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling
Marada, S., Navarro, G., Truong, A., Stewart, D. P., Arensdorf, A. M., Nachtergaele, S., . . . Ogden, S. K. (2015). Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling. PLOS Genetics, 11(8), e1005473. doi:10.1371/journal.pgen.1005473
INSULIN GROWTH FACTOR I AND ITS RECEPTOR ARE ANTAGONISTIC MODULATORS OF GLUCOSE HANDLING BY ASTROCYTES
Role of Cannabinoid Receptor CB2 in HER2 Pro-oncogenic Signaling in Breast Cancer
Pérez-Gómez, E., Andradas, C., Blasco-Benito, S., Caffarel, M. M., García-Taboada, E., Villa-Morales, M., . . . Sánchez, C. (2015). Role of Cannabinoid Receptor CB2 in HER2 Pro-oncogenic Signaling in Breast Cancer. JNCI: Journal of the National Cancer Institute, 107(6). doi:10.1093/jnci/djv077
Orexin–Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine
Navarro, G., Quiroz, C., Moreno-Delgado, D., Sierakowiak, A., McDowell, K., Moreno, E., . . . McCormick, P. J. (2015). Orexin–Corticotropin-Releasing Factor Receptor Heteromers in the Ventral Tegmental Area as Targets for Cocaine. The Journal of Neuroscience, 35(17), 6639-6653. doi:10.1523/jneurosci.4364-14.2015
Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors
Viñals, X., Moreno, E., Lanfumey, L., Cordomí, A., Pastor, A., de La Torre, R., . . . Robledo, P. (2015). Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors. PLOS Biology, 13(7), e1002194. doi:10.1371/journal.pbio.1002194
2014
Intracellular Calcium Levels Determine Differential Modulation of Allosteric Interactions within G Protein-Coupled Receptor Heteromers
Navarro, G., Aguinaga, D., Moreno, E., Hradsky, J., Reddy, P. P., Cortés, A., . . . Ferré, S. (2014). Intracellular Calcium Levels Determine Differential Modulation of Allosteric Interactions within G Protein-Coupled Receptor Heteromers. Chemistry & Biology, 21(11), 1546-1556. doi:10.1016/j.chembiol.2014.10.004
Functional Selectivity of Allosteric Interactions within G Protein–Coupled Receptor Oligomers: The Dopamine D1-D3 Receptor Heterotetramer
Guitart, X., Navarro, G., Moreno, E., Yano, H., Cai, N. -S., Sánchez-Soto, M., . . . Ferré, S. (2014). Functional Selectivity of Allosteric Interactions within G Protein–Coupled Receptor Oligomers: The Dopamine D1-D3 Receptor Heterotetramer. Molecular Pharmacology, 86(4), 417-429. doi:10.1124/mol.114.093096
M17 Targeting Dopamine D1-histamine H3 Receptor Heteromers As A Therapeutical Strategy To Prevent Cognitive Deficits And Neurodegeneration In Huntington's Disease
Canadell, M., Moreno-Delgado, D., Rodriguez-Ruiz, M., Moreno, E., Botta, J., Gasperini, P., . . . Gines, S. (2014). M17 Targeting Dopamine D1-histamine H3 Receptor Heteromers As A Therapeutical Strategy To Prevent Cognitive Deficits And Neurodegeneration In Huntington's Disease. In Journal of Neurology, Neurosurgery & Psychiatry Vol. 85 (pp. A100). BMJ. doi:10.1136/jnnp-2014-309032.289
Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling
Moreno, E., Andradas, C., Medrano, M., Caffarel, M. M., Pérez-Gómez, E., Blasco-Benito, S., . . . Sánchez, C. (2014). Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling. Journal of Biological Chemistry, 289(32), 21960-21972. doi:10.1074/jbc.m114.561761
Telomerase Variant A279T Induces Telomere Dysfunction and Inhibits Non-Canonical Telomerase Activity in Esophageal Carcinomas
Zhang, Y., Calado, R., Rao, M., Hong, J. A., Meeker, A. K., Dumitriu, B., . . . Schrump, D. S. (2014). Telomerase Variant A279T Induces Telomere Dysfunction and Inhibits Non-Canonical Telomerase Activity in Esophageal Carcinomas. PLoS ONE, 9(7), e101010. doi:10.1371/journal.pone.0101010
l-DOPA-treatment in primates disrupts the expression of A2A adenosine–CB1 cannabinoid–D2 dopamine receptor heteromers in the caudate nucleus
Bonaventura, J., Rico, A. J., Moreno, E., Sierra, S., Sánchez, M., Luquin, N., . . . Franco, R. (2014). l-DOPA-treatment in primates disrupts the expression of A2A adenosine–CB1 cannabinoid–D2 dopamine receptor heteromers in the caudate nucleus. Neuropharmacology, 79, 90-100. doi:10.1016/j.neuropharm.2013.10.036
Cocaine Disrupts Histamine H<sub>3</sub>Receptor Modulation of Dopamine D<sub>1</sub>Receptor Signaling: σ<sub>1</sub>-D<sub>1</sub>-H<sub>3</sub>Receptor Complexes as Key Targets for Reducing Cocaine's Effects
Moreno, E., Moreno-Delgado, D., Navarro, G., Hoffmann, H. M., Fuentes, S., Rosell-Vilar, S., . . . McCormick, P. J. (2014). Cocaine Disrupts Histamine H<sub>3</sub>Receptor Modulation of Dopamine D<sub>1</sub>Receptor Signaling: σ<sub>1</sub>-D<sub>1</sub>-H<sub>3</sub>Receptor Complexes as Key Targets for Reducing Cocaine's Effects. The Journal of Neuroscience, 34(10), 3545-3558. doi:10.1523/jneurosci.4147-13.2014
l-DOPA disrupts adenosine A2A–cannabinoid CB1–dopamine D2 receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies
Pinna, A., Bonaventura, J., Farré, D., Sánchez, M., Simola, N., Mallol, J., . . . Franco, R. (2014). l-DOPA disrupts adenosine A2A–cannabinoid CB1–dopamine D2 receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies. Experimental Neurology, 253, 180-191. doi:10.1016/j.expneurol.2013.12.021
Allosteric communication between Gi and Gs in the adenosine A1-A<sub>2A</sub> receptor tetrameric complex
Franco, R., Cordomi, A., Zelman-Femiak, M., Brugarolas, M., Moreno, E., Cortes, A., . . . Navarro, G. (2014). Allosteric communication between Gi and Gs in the adenosine A1-A<sub>2A</sub> receptor tetrameric complex. In PURINERGIC SIGNALLING Vol. 10 (pp. 738). Retrieved from https://www.webofscience.com/
Evidence for adenosine A<sub>1</sub>-A<sub>2A</sub> receptor heteromers in neurons and astrocytes
Navarro, G., Cordom, A., Zelman-Femiak, M., Brugarolas, M., Aguinaga, D., Medrano, M., . . . Franco, R. (2014). Evidence for adenosine A<sub>1</sub>-A<sub>2A</sub> receptor heteromers in neurons and astrocytes. In PURINERGIC SIGNALLING Vol. 10 (pp. 738). Retrieved from https://www.webofscience.com/
INVESTIGATION OF THE DIMERIZATION INTERFACE OF THE SEROTONIN 5-HT<sub>2A</sub> RECEPTOR BY COMPUTATIONAL AND EXPERIMENTAL APPROACHES
de la Fuente Gonzalez, R. A., Garcia Silva, A., Moreno Guillen, E., McCormick, P. J., Marti Solano, M., Cadavid, T. M. I., . . . Castro Perez, M. (2014). INVESTIGATION OF THE DIMERIZATION INTERFACE OF THE SEROTONIN 5-HT<sub>2A</sub> RECEPTOR BY COMPUTATIONAL AND EXPERIMENTAL APPROACHES. In BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Vol. 115 (pp. 49). Retrieved from https://www.webofscience.com/
2013
Homodimerization of adenosine A1 receptors in brain cortex explains the biphasic effects of caffeine
Gracia, E., Moreno, E., Cortés, A., Lluís, C., Mallol, J., McCormick, P. J., . . . Casadó, V. (2013). Homodimerization of adenosine A1 receptors in brain cortex explains the biphasic effects of caffeine. Neuropharmacology, 71, 56-69. doi:10.1016/j.neuropharm.2013.03.005
Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers
Navarro, G., Moreno, E., Bonaventura, J., Brugarolas, M., Farré, D., Aguinaga, D., . . . McCormick, P. J. (2013). Cocaine Inhibits Dopamine D2 Receptor Signaling via Sigma-1-D2 Receptor Heteromers. PLoS ONE, 8(4), e61245. doi:10.1371/journal.pone.0061245
The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors
Gracia, E., Farré, D., Cortés, A., Ferrer‐Costa, C., Orozco, M., Mallol, J., . . . Casadó, V. (2013). The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors. The FASEB Journal, 27(3), 1048-1061. doi:10.1096/fj.12-212621
Retraction: Cristóvão-Ferreira et al., Modulation of GABA Transport by Adenosine A <sub>1</sub> R–A <sub>2A</sub> R Heteromers, Which Are Coupled to Both G <sub>s</sub> - and G <sub>i/o</sub> -Proteins
Retraction: Cristóvão-Ferreira et al., Modulation of GABA Transport by Adenosine A <sub>1</sub> R–A <sub>2A</sub> R Heteromers, Which Are Coupled to Both G <sub>s</sub> - and G <sub>i/o</sub> -Proteins (2013). The Journal of Neuroscience, 33(3), 1292.2-1292. doi:10.1523/jneurosci.5705-12.2013
A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes
Cristóvão-Ferreira, S., Navarro, G., Brugarolas, M., Pérez-Capote, K., Vaz, S. H., Fattorini, G., . . . Sebastião, A. M. (2013). A1R–A2AR heteromers coupled to Gs and Gi/0 proteins modulate GABA transport into astrocytes. Purinergic Signalling, 9(3), 433-449. doi:10.1007/s11302-013-9364-5
Challenges in the Development of Heteromer-GPCR-Based Drugs
Franco, R., Martínez-Pinilla, E., Ricobaraza, A., & McCormick, P. J. (2013). Challenges in the Development of Heteromer-GPCR-Based Drugs. In Progress in Molecular Biology and Translational Science (pp. 143-162). Elsevier. doi:10.1016/b978-0-12-386931-9.00006-4
Detection of Receptor Heteromers Involving Dopamine Receptors by the Sequential BRET-FRET Technology
Navarro, G., McCormick, P. J., Mallol, J., Lluís, C., Franco, R., Cortés, A., . . . Ferré, S. (2013). Detection of Receptor Heteromers Involving Dopamine Receptors by the Sequential BRET-FRET Technology. Unknown Journal, 95-105. doi:10.1007/978-1-62703-251-3_7
2012
Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected Individuals
Casanova, V., Naval-Macabuhay, I., Massanella, M., Rodríguez-García, M., Blanco, J., Gatell, J. M., . . . McCormick, P. J. (2012). Adenosine Deaminase Enhances the Immunogenicity of Human Dendritic Cells from Healthy and HIV-Infected Individuals. PLoS ONE, 7(12), e51287. doi:10.1371/journal.pone.0051287
Loading dendritic cells from HIV-1 infected patients with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses
Climent, N., Munier, S., Piqué, N., García, F., Pavot, V., León, A., . . . Gallart, T. (2012). Loading dendritic cells from HIV-1 infected patients with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses. In Retrovirology Vol. 9. Springer Science and Business Media LLC. doi:10.1186/1742-4690-9-s2-p247
Unmasking adenosine 2A receptors (A2ARs) in monkey basal ganglia output neurons using cholera toxin subunit B (CTB)
Luquin, N., Sierra, S., Rico, A. J., Gómez-Bautista, V., Roda, E., Conte-Perales, L., . . . Lanciego, J. L. (2012). Unmasking adenosine 2A receptors (A2ARs) in monkey basal ganglia output neurons using cholera toxin subunit B (CTB). Neurobiology of Disease, 47(3), 347-357. doi:10.1016/j.nbd.2012.05.006
Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain
Callén, L., Moreno, E., Barroso-Chinea, P., Moreno-Delgado, D., Cortés, A., Mallol, J., . . . McCormick, P. J. (2012). Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain. Journal of Biological Chemistry, 287(25), 20851-20865. doi:10.1074/jbc.m111.335273
Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain
González, S., Rangel-Barajas, C., Peper, M., Lorenzo, R., Moreno, E., Ciruela, F., . . . Ferré, S. (2012). Dopamine D4 receptor, but not the ADHD-associated D4.7 variant, forms functional heteromers with the dopamine D2S receptor in the brain. Molecular Psychiatry, 17(6), 650-662. doi:10.1038/mp.2011.93
NCS-1 associates with adenosine A2A receptors and modulates receptor function
Navarro, G., Hradsky, J., Lluís, C., Casadó, V., McCormick, P. J., Kreutz, M. R., & Mikhaylova, M. (2012). NCS-1 associates with adenosine A2A receptors and modulates receptor function. Frontiers in Molecular Neuroscience, 5. doi:10.3389/fnmol.2012.00053
Kaposi Sarcoma Herpesvirus Promotes Endothelial-to-Mesenchymal Transition through Notch-Dependent Signaling
Gasperini, P., Espigol-Frigole, G., McCormick, P. J., Salvucci, O., Maric, D., Uldrick, T. S., . . . Tosato, G. (2012). Kaposi Sarcoma Herpesvirus Promotes Endothelial-to-Mesenchymal Transition through Notch-Dependent Signaling. Cancer Research, 72(5), 1157-1169. doi:10.1158/0008-5472.can-11-3067
Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland
González, S., Moreno-Delgado, D., Moreno, E., Pérez-Capote, K., Franco, R., Mallol, J., . . . McCormick, P. J. (2012). Circadian-Related Heteromerization of Adrenergic and Dopamine D4 Receptors Modulates Melatonin Synthesis and Release in the Pineal Gland. PLoS Biology, 10(6), e1001347. doi:10.1371/journal.pbio.1001347
2011
Post-translational Membrane Insertion of Tail-anchored Transmembrane EF-hand Ca2+ Sensor Calneurons Requires the TRC40/Asna1 Protein Chaperone
Hradsky, J., Raghuram, V., Reddy, P. P., Navarro, G., Hupe, M., Casado, V., . . . Mikhaylova, M. (2011). Post-translational Membrane Insertion of Tail-anchored Transmembrane EF-hand Ca2+ Sensor Calneurons Requires the TRC40/Asna1 Protein Chaperone. Journal of Biological Chemistry, 286(42), 36762-36776. doi:10.1074/jbc.m111.280339
Dopamine–Galanin Receptor Heteromers Modulate Cholinergic Neurotransmission in the Rat Ventral Hippocampus
Moreno, E., Vaz, S. H., Cai, N. -S., Ferrada, C., Quiroz, C., Barodia, S. K., . . . Ferré, S. (2011). Dopamine–Galanin Receptor Heteromers Modulate Cholinergic Neurotransmission in the Rat Ventral Hippocampus. The Journal of Neuroscience, 31(20), 7412-7423. doi:10.1523/jneurosci.0191-11.2011
Biotin Ergopeptide Probes for Dopamine Receptors
Vendrell, M., Molero, A., González, S., Pérez-Capote, K., Lluis, C., McCormick, P. J., . . . Royo, M. (2011). Biotin Ergopeptide Probes for Dopamine Receptors. Journal of Medicinal Chemistry, 54(4), 1080-1090. doi:10.1021/jm101566d
Dopamine D1-histamine H3 Receptor Heteromers Provide a Selective Link to MAPK Signaling in GABAergic Neurons of the Direct Striatal Pathway
Moreno, E., Hoffmann, H., Gonzalez-Sepúlveda, M., Navarro, G., Casadó, V., Cortés, A., . . . Franco, R. (2011). Dopamine D1-histamine H3 Receptor Heteromers Provide a Selective Link to MAPK Signaling in GABAergic Neurons of the Direct Striatal Pathway. Journal of Biological Chemistry, 286(7), 5846-5854. doi:10.1074/jbc.m110.161489
Modulation of GABA Transport by Adenosine A <sub>1</sub> R–A <sub>2A</sub> R Heteromers, Which Are Coupled to Both G <sub>s</sub> - and G <sub>i/o</sub> -Proteins
Cristóvão-Ferreira, S., Navarro, G., Brugarolas, M., Pérez-Capote, K., Vaz, S. H., Fattorini, G., . . . Sebastião, A. M. (2011). Modulation of GABA Transport by Adenosine A <sub>1</sub> R–A <sub>2A</sub> R Heteromers, Which Are Coupled to Both G <sub>s</sub> - and G <sub>i/o</sub> -Proteins. The Journal of Neuroscience, 31(44), 15629-15639. doi:10.1523/jneurosci.2526-11.2011
2010
Direct involvement of σ-1 receptors in the dopamine D <sub>1</sub> receptor-mediated effects of cocaine
Navarro, G., Moreno, E., Aymerich, M., Marcellino, D., McCormick, P. J., Mallol, J., . . . Franco, R. (2010). Direct involvement of σ-1 receptors in the dopamine D <sub>1</sub> receptor-mediated effects of cocaine. Proceedings of the National Academy of Sciences, 107(43), 18676-18681. doi:10.1073/pnas.1008911107
The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1
de la Luz Sierra, M., Sakakibara, S., Gasperini, P., Salvucci, O., Jiang, K., McCormick, P. J., . . . Tosato, G. (2010). The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1. Blood, 115(19), 3970-3979. doi:10.1182/blood-2009-10-246967
2009
Impaired Recruitment of Grk6 and β-Arrestin2 Causes Delayed Internalization and Desensitization of a WHIM Syndrome-Associated CXCR4 Mutant Receptor
McCormick, P. J., Segarra, M., Gasperini, P., Gulino, A. V., & Tosato, G. (2009). Impaired Recruitment of Grk6 and β-Arrestin2 Causes Delayed Internalization and Desensitization of a WHIM Syndrome-Associated CXCR4 Mutant Receptor. PLoS ONE, 4(12), e8102. doi:10.1371/journal.pone.0008102
2008
Palmitoylation Controls Recycling in Lysosomal Sorting and Trafficking
McCormick, P. J., Dumaresq‐Doiron, K., Pluviose, A., Pichette, V., Tosato, G., & Lefrancois, S. (2008). Palmitoylation Controls Recycling in Lysosomal Sorting and Trafficking. Traffic, 9(11), 1984-1997. doi:10.1111/j.1600-0854.2008.00814.x
Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth
Segarra, M., Williams, C. K., Sierra, M. D. L. L., Bernardo, M., McCormick, P. J., Maric, D., . . . Tosato, G. (2008). Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth. Blood, 112(5), 1904-1911. doi:10.1182/blood-2007-11-126045
CD1a and MHC Class I Follow a Similar Endocytic Recycling Pathway
Barral, D. C., Cavallari, M., McCormick, P. J., Garg, S., Magee, A. I., Bonifacino, J. S., . . . Brenner, M. B. (2008). CD1a and MHC Class I Follow a Similar Endocytic Recycling Pathway. Traffic, 9(9), 1446-1457. doi:10.1111/j.1600-0854.2008.00781.x
2007
The Arf GEF GBF1 Is Required for GGA Recruitment to Golgi Membranes
Lefrançois, S., & McCormick, P. J. (2007). The Arf GEF GBF1 Is Required for GGA Recruitment to Golgi Membranes. Traffic, 8(10), 1440-1451. doi:10.1111/j.1600-0854.2007.00623.x
Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells
De La Luz Sierra, M., Gasperini, P., McCormick, P. J., Zhu, J., & Tosato, G. (2007). Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells. Blood, 110(7), 2276-2285. doi:10.1182/blood-2007-03-081448
Sec61α and TRAM are Sequentially Adjacent to a Nascent Viral Membrane Protein during its ER Integration
Saurí, A., McCormick, P. J., Johnson, A. E., & Mingarro, I. (2007). Sec61α and TRAM are Sequentially Adjacent to a Nascent Viral Membrane Protein during its ER Integration. Journal of Molecular Biology, 366(2), 366-374. doi:10.1016/j.jmb.2006.11.052
2006
EphB2 and EphB4 receptors forward signaling promotes SDF-1–induced endothelial cell chemotaxis and branching remodeling
Salvucci, O., de la Luz Sierra, M., Martina, J. A., McCormick, P. J., & Tosato, G. (2006). EphB2 and EphB4 receptors forward signaling promotes SDF-1–induced endothelial cell chemotaxis and branching remodeling. Blood, 108(9), 2914-2922. doi:10.1182/blood-2006-05-023341
2005
Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments
McCormick, P. J., Martina, J. A., & Bonifacino, J. S. (2005). Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments. Proceedings of the National Academy of Sciences, 102(22), 7910-7915. doi:10.1073/pnas.0502206102
2004
Nascent Membrane and Secretory Proteins Differ in FRET-Detected Folding Far inside the Ribosome and in Their Exposure to Ribosomal Proteins
Woolhead, C. A., McCormick, P. J., & Johnson, A. E. (2004). Nascent Membrane and Secretory Proteins Differ in FRET-Detected Folding Far inside the Ribosome and in Their Exposure to Ribosomal Proteins. Cell, 116(5), 725-736. doi:10.1016/s0092-8674(04)00169-2
2003
Cotranslational Protein Integration into the ER Membrane Is Mediated by the Binding of Nascent Chains to Translocon Proteins
McCormick, P. J., Miao, Y., Shao, Y., Lin, J., & Johnson, A. E. (2003). Cotranslational Protein Integration into the ER Membrane Is Mediated by the Binding of Nascent Chains to Translocon Proteins. Molecular Cell, 12(2), 329-341. doi:10.1016/s1097-2765(03)00304-6