Research outputs
Selected research outputs
- Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells (Journal article - 2018)
- New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors (Journal article - 2018)
- Live and let die: insights into pseudoenzyme mechanisms from structure (Journal article - 2017)
- Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity (Journal article - 2020)
- Tracing the origin and evolution of pseudokinases across the tree of life (Journal article - 2019)
- Evolutionary and cellular analysis of the dark pseudokinase PSKH2 (Preprint - 2022)
- Mechanistic and evolutionary insights into isoform-specific 'supercharging' in DCLK family kinases. (Journal article - 2023)
- PSKH1 kinase activity is differentially modulated via allosteric binding of Ca<sup>2+</sup> sensor proteins. (Journal article - 2025)
- Searching for Sulfotyrosines (sY) in a HA(pY)STACK. (Journal article - 2025)
- Discovery of a Cushing’s syndrome protein kinase A mutant that biases signaling through type I AKAPs (Journal article - 2024)
2025
Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence.
Nolan, A., Foulkes, D. M., Fairweather, E. E., Alarcon, M. F., Linford, C., Sellin, A., . . . Wright, H. (2025). Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence.. Rheumatology (Oxford). doi:10.1093/rheumatology/keaf437
Applying a Conservation-Based Approach for Predicting Novel Phosphorylation Sites in Eukaryotes and Evaluating Their Functional Relevance.
Kalyuzhnyy, A., Eyers, P. A., Eyers, C. E., Deutsch, E. W., & Jones, A. R. (2025). Applying a Conservation-Based Approach for Predicting Novel Phosphorylation Sites in Eukaryotes and Evaluating Their Functional Relevance.. Journal of proteome research. doi:10.1021/acs.jproteome.5c00278
Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence
Pervanadate-induced oxidation relieves autoinhibition of SRC protein tyrosine kinase
Redox regulation and dynamic control of brain-selective kinases BRSK1/2 in the AMPK family through cysteine-based mechanisms
Bendzunas, G. N., Byrne, D. P., Shrestha, S., Daly, L. A., Oswald, S. O., Katiyar, S., . . . Kannan, N. (2025). Redox regulation and dynamic control of brain-selective kinases BRSK1/2 in the AMPK family through cysteine-based mechanisms. eLife, 13. doi:10.7554/elife.92536.4
Searching for Sulfotyrosines (sY) in a HA(pY)STACK.
Tzvetkov, J., Eyers, C. E., Eyers, P. A., Ramsbottom, K. A., Oswald, S. O., Harris, J. A., . . . Jones, A. R. (2025). Searching for Sulfotyrosines (sY) in a HA(pY)STACK.. Journal of proteome research. doi:10.1021/acs.jproteome.4c00907
PSKH1 kinase activity is differentially modulated via allosteric binding of Ca<sup>2+</sup> sensor proteins.
Horne, C. R., Dite, T. A., Young, S. N., Mather, L. J., Dagley, L. F., Johnson, J. L., . . . Murphy, J. M. (2025). PSKH1 kinase activity is differentially modulated via allosteric binding of Ca<sup>2+</sup> sensor proteins.. Proceedings of the National Academy of Sciences of the United States of America, 122(8), e2420961122. doi:10.1073/pnas.2420961122
The MYCN/Aurora-A complex is a cyclin activating kinase for CDK12
Applying a conservation-based approach for predicting novel phosphorylation sites in eukaryotes and evaluating their functional relevance
2024
PSKH1 kinase activity is differentially modulated via allosteric binding of Ca<sup>2+</sup>sensor proteins
RAF inhibitors activate the integrated stress response by direct activation of GCN2
Activation loop phosphorylation of Cdk11 is restrained by PNUTS-PP1 and regulates Cdk11 activity and function
Discovery of a Cushing’s syndrome protein kinase A mutant that biases signaling through type I AKAPs
Omar, M. H., Byrne, D. P., Shrestha, S., Lakey, T. M., Lee, K. -S., Lauer, S. M., . . . Scott, J. D. (2024). Discovery of a Cushing’s syndrome protein kinase A mutant that biases signaling through type I AKAPs. Science Advances, 10(8). doi:10.1126/sciadv.adl1258
2023
Custom Workflow for the Confident Identification of Sulfotyrosine-Containing Peptides and Their Discrimination from Phosphopeptides.
Daly, L. A., Byrne, D. P., Perkins, S., Brownridge, P. J., McDonnell, E., Jones, A. R., . . . Eyers, C. E. (2023). Custom Workflow for the Confident Identification of Sulfotyrosine-Containing Peptides and Their Discrimination from Phosphopeptides.. Journal of proteome research, 22(12), 3754-3772. doi:10.1021/acs.jproteome.3c00425
Mechanistic and evolutionary insights into isoform-specific 'supercharging' in DCLK family kinases.
Venkat, A., Watterson, G., Byrne, D. P., O'Boyle, B., Shrestha, S., Gravel, N., . . . Kannan, N. (2023). Mechanistic and evolutionary insights into isoform-specific 'supercharging' in DCLK family kinases.. eLife, 12, RP87958. doi:10.7554/elife.87958
18P AURKB inhibition radiosensitises NSCLC by altering mitotic fate
Egerton, K., Mitchell, T. A., Gravells, P., Katse, R., Fisher, M., Muthana, M., . . . Bryant, H. E. (2023). 18P AURKB inhibition radiosensitises NSCLC by altering mitotic fate. ESMO Open, 8(1), 101664. doi:10.1016/j.esmoop.2023.101664
A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms
Cao, M., Day, A. M., Galler, M., Latimer, H. R., Byrne, D. P., Foy, T. W., . . . Veal, E. A. (2023). A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms. MOLECULAR CELL, 83(17), 3140-+. doi:10.1016/j.molcel.2023.07.018
Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI
Omar, M. H., Kihiu, M., Byrne, D. P., Lee, K. -S., Lakey, T. M., Butcher, E., . . . Scott, J. D. (2023). Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI. BIOCHEMICAL JOURNAL, 480(12), 875-890. doi:10.1042/BCJ20230183
Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases
Venkat, A., Watterson, G., Byrne, D. P., O’Boyle, B., Shrestha, S., Gravel, N., . . . Kannan, N. (2023). Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases. doi:10.7554/elife.87958.1
ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1
Balmanno, K., Kidger, A. M., Byrne, D. P., Sale, M. J., Nassman, N., Eyers, P. A., & Cook, S. J. (2023). ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1. BIOCHEMICAL JOURNAL, 480(9), 587-605. doi:10.1042/BCJ20220598
Evolutionary and cellular analysis of the 'dark' pseudokinase PSKH2
Byrne, D. P., Shrestha, S., Daly, L. A., Marensi, V., Ramakrishnan, K., Eyers, C. E., . . . Eyers, P. A. (2023). Evolutionary and cellular analysis of the 'dark' pseudokinase PSKH2. BIOCHEMICAL JOURNAL, 480(2), 141-160. doi:10.1042/BCJ20220474
2022
A Peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms
Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota
Luis, A. S., Basle, A., Byrne, D. P., Wright, G. S. A., London, J. A., Jin, C., . . . Cartmell, A. (2022). Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota. NATURE CHEMICAL BIOLOGY, 18(8), 841-+. doi:10.1038/s41589-022-01039-x
Profiling the Human Phosphoproteome to Estimate the True Extent of Protein Phosphorylation
Kalyuzhnyy, A., Eyers, P. A., Eyers, C. E., Bowler-Barnett, E., Martin, M. J., Sun, Z., . . . Jones, A. R. (2022). Profiling the Human Phosphoproteome to Estimate the True Extent of Protein Phosphorylation. JOURNAL OF PROTEOME RESEARCH, 21(6), 1510-1524. doi:10.1021/acs.jproteome.2c00131
Catalytic degradation in pseudoenzymes
Eyers, P. (2022). Catalytic degradation in pseudoenzymes. The FASEB Journal, 36(S1). doi:10.1096/fasebj.2022.36.s1.0i116
Exploring the conformational landscape and stability of Aurora A using ion-mobility mass spectrometry and molecular modelling
Tomlinson, L. J., Batchelor, M., Sarsby, J., Byrne, D. P., Brownridge, P., Bayliss, R., . . . Eyers, C. E. (2022). Exploring the conformational landscape and stability of Aurora A using ion-mobility mass spectrometry and molecular modelling. Journal of the American Society for Mass Spectrometry. doi:10.1021/jasms.1c00271
Analysis of human Tribbles 2 (TRIB2) pseudokinase
Harris, J. A., Fairweather, E., Byrne, D. P., & Eyers, P. A. (2022). Analysis of human Tribbles 2 (TRIB2) pseudokinase. In PSEUDOKINASES (Vol. 667, pp. 79-99). doi:10.1016/bs.mie.2022.03.025
Biochemical Analysis of AKAP-Anchored PKA Signaling Complexes.
Byrne, D. P., Omar, M. H., Kennedy, E. J., Eyers, P. A., & Scott, J. D. (2022). Biochemical Analysis of AKAP-Anchored PKA Signaling Complexes.. Methods in molecular biology (Clifton, N.J.), 2483, 297-317. doi:10.1007/978-1-0716-2245-2_19
Computational tools and resources for pseudokinase research
O'Boyle, B., Shrestha, S., Kochut, K., Eyers, P. A., & Kannan, N. (2022). Computational tools and resources for pseudokinase research. In PSEUDOKINASES (Vol. 667, pp. 403-426). doi:10.1016/bs.mie.2022.03.040
2021
Displacement of PKA catalytic subunit from AKAP signaling islands drives pathology in Cushing’s syndrome
A single sulfatase is required to access colonic mucin by a gut bacterium
Luis, A. S., Jin, C., Pereira, G. V., Glowacki, R. W. P., Gugel, S. R., Singh, S., . . . Martens, E. C. (2021). A single sulfatase is required to access colonic mucin by a gut bacterium. NATURE, 598(7880), 332-+. doi:10.1038/s41586-021-03967-5
Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
Meyer, B., Chiaravalli, J., Gellenoncourt, S., Brownridge, P., Bryne, D. P., Daly, L. A., . . . Emmott, E. (2021). Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-25796-w
KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases.
Huang, L. -C., Taujale, R., Gravel, N., Venkat, A., Yeung, W., Byrne, D. P., . . . Kannan, N. (2021). KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases.. BMC bioinformatics, 22(1), 446. doi:10.1186/s12859-021-04358-3
Sulfated host glycan recognition by carbohydrate sulfatases of the human gut microbiota
KinOrtho: a method for mapping human kinase orthologs across the tree of life and illuminating understudied kinases
Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity
Byrne, D. P., London, J. A., Eyers, P. A., Yates, E. A., & Cartmell, A. (2021). Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity. BIOCHEMICAL JOURNAL, 478(4), 735-748. doi:10.1042/BCJ20200952
Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity (vol 478, pg 735, 2021)
Byrne, D. P., London, J. A., Eyers, P. A., Yates, E. A., & Cartmell, A. (2021). Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity (vol 478, pg 735, 2021). BIOCHEMICAL JOURNAL, 478(1), 2537-2538. doi:10.1042/BCJ20200952_COR
A single bacterial sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium
2020
Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity
Byrne, D., London, J., Eyers, P., Yates, E., & Cartmell, A. (2020). Mobility shift-based electrophoresis coupled with fluorescent detection enables real-time enzyme analysis of carbohydrate sulfatase activity. doi:10.1101/2020.12.01.406876
A single bacterial sulfatase is required for metabolism of colonic mucin<i>O</i>-glycans and intestinal colonization by a symbiotic human gut bacterium
Marveling at the Incredible ULK4
Eyers, P. A. (2020). Marveling at the Incredible ULK4. STRUCTURE, 28(11), 1181-1183. doi:10.1016/j.str.2020.10.005
Cataloguing the dead: breathing new life into pseudokinase research
Shrestha, S., Byrne, D. P., Harris, J. A., Kannan, N., & Eyers, P. A. (2020). Cataloguing the dead: breathing new life into pseudokinase research. FEBS JOURNAL, 287(19), 4150-4169. doi:10.1111/febs.15246
A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily
Shrestha, S., Katiyar, S., Sanz-Rodriguez, C. E., Kemppinen, N. R., Kim, H. W., Kadirvelraj, R., . . . Kannan, N. (2020). A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily. Science Signaling, 13(639). doi:10.1126/scisignal.aax6313
Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity
Byrne, D. P., Shrestha, S., Galler, M., Cao, M., Daly, L. A., Campbell, A. E., . . . Eyers, P. A. (2020). Aurora A regulation by reversible cysteine oxidation reveals evolutionarily conserved redox control of Ser/Thr protein kinase activity. Science Signaling, 13(639). doi:10.1126/scisignal.aax2713
Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics
Byrne, D. P., Clarke, C. J., Brownridge, P. J., Kalyuzhnyy, A., Perkins, S., Campbell, A., . . . Eyers, C. E. (2020). Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics. The Biochemical journal, 477(13), 2451-2475. doi:10.1042/bcj20200309
Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signaling networks using SILAC-based phosphoproteomics
A novel redox-active switch in Fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily
Analysis of 1-and 3-Phosphohistidine (pHis) Protein Modification Using Model Enzymes Expressed in Bacteria
Coldron, A. K. M. C., Byrne, D. P., & Eyers, P. A. (2020). Analysis of 1-and 3-Phosphohistidine (pHis) Protein Modification Using Model Enzymes Expressed in Bacteria. HISTIDINE PHOSPHORYLATION, 2077, 63-81. doi:10.1007/978-1-4939-9884-5_5
Covalent Aurora A regulation by the metabolic integrator coenzyme A
Tsuchiya, Y., Byrne, D. P., Burgess, S. G., Bormann, J., Bakovic, J., Huang, Y., . . . Gout, I. (2020). Covalent Aurora A regulation by the metabolic integrator coenzyme A. REDOX BIOLOGY, 28. doi:10.1016/j.redox.2019.101318
Determination of Phosphohistidine Stoichiometry in Histidine Kinases by Intact Mass Spectrometry
Tomlinson, L. J., Coldron, A. K. M. C., Eyers, P. A., & Eyers, C. E. (2020). Determination of Phosphohistidine Stoichiometry in Histidine Kinases by Intact Mass Spectrometry. HISTIDINE PHOSPHORYLATION, 2077, 83-91. doi:10.1007/978-1-4939-9884-5_6
2019
Strong anion exchange-mediated phosphoproteomics reveals extensive human non-canonical phosphorylation
Hardman, G., Perkins, S., Brownridge, P., Clarke, C., Byrne, D., Campbell, A., . . . Eyers, C. (2019). Strong anion exchange-mediated phosphoproteomics reveals extensive human non-canonical phosphorylation. The EMBO Journal, 38(21). doi:10.15252/embj.2018100847
Structure-Based Design of Nucleoside-Derived Analogues as Sulfotransferase Inhibitors
Kershaw, N., Byrne, D., Parsons, H., Berry, N., Fernig, D., Eyers, P., & Cosstick, R. (2019). Structure-Based Design of Nucleoside-Derived Analogues as Sulfotransferase Inhibitors. RSC Advances: an international journal to further the chemical sciences. doi:10.1039/C9RA07567D
Emerging concepts in pseudoenzyme classification, evolution, and signaling
Ribeiro, A. J. M., Das, S., Dawson, N., Zaru, R., Orchard, S., Thornton, J. M., . . . Eyers, P. A. (2019). Emerging concepts in pseudoenzyme classification, evolution, and signaling. SCIENCE SIGNALING, 12(594). doi:10.1126/scisignal.aat9797
Metabolic control of BRISC-SHMT2 assembly regulates immune signalling
Walden, M., Tian, L., Ross, R. L., Sykora, U. M., Byrne, D. P., Hesketh, E. L., . . . Zeqiraj, E. (2019). Metabolic control of BRISC-SHMT2 assembly regulates immune signalling. NATURE, 570(7760), 194-+. doi:10.1038/s41586-019-1232-1
BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-X-L
Greaves, G., Milani, M., Butterworth, M., Carter, R. J., Byrne, D. P., Eyers, P. A., . . . Varadarajan, S. (2019). BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-X-L. CELL DEATH AND DIFFERENTIATION, 26(6), 1037-1047. doi:10.1038/s41418-018-0183-7
Tracing the origin and evolution of pseudokinases across the tree of life
Kwon, A., Scott, S., Taujale, R., Yeung, W., Kochut, K. J., Eyers, P. A., & Kannan, N. (2019). Tracing the origin and evolution of pseudokinases across the tree of life. SCIENCE SIGNALING, 12(578). doi:10.1126/scisignal.aav3810
Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer
Cui, B., Eyers, P. A., Dobens, L. L., Tan, N. S., Mace, P. D., Link, W. A., . . . Hu, Z. (2019). Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer. ACTA PHARMACEUTICA SINICA B, 9(2), 443-454. doi:10.1016/j.apsb.2018.12.007
Towards 20,20-difluorinated bryostatin: synthesis and biological evaluation of C17,C27-fragments
Mears, P. R., Hoekman, S., Rye, C. E., Bailey, F. P., Byrne, D. P., Eyers, P. A., & Thomas, E. J. (2019). Towards 20,20-difluorinated bryostatin: synthesis and biological evaluation of C17,C27-fragments. ORGANIC & BIOMOLECULAR CHEMISTRY, 17(6), 1487-1505. doi:10.1039/c8ob03152e
DNA Binding and Phosphorylation Regulate the Core Structure of the NF-B p50 Transcription Factor
Vonderach, M., Byrne, D. P., Barran, P. E., Eyers, P. A., & Eyers, C. E. (2019). DNA Binding and Phosphorylation Regulate the Core Structure of the NF-B p50 Transcription Factor. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 30(1), 128-138. doi:10.1007/s13361-018-1984-0
2018
Drug repurposing: progress, challenges and recommendations
Pushpakom, S., Iorio, F., Eyers, P. A., Escott, K. J., Hopper, S., Wells, A., . . . Pirmohamed, M. (2019). Drug repurposing: progress, challenges and recommendations. NATURE REVIEWS DRUG DISCOVERY, 18(1), 41-58. doi:10.1038/nrd.2018.168
A new consensus for evaluating CDKL5/STK9-dependent signalling mechanisms
Eyers, P. A. (2018). A new consensus for evaluating CDKL5/STK9-dependent signalling mechanisms. EMBO JOURNAL, 37(24). doi:10.15252/embj.2018100848
Covalent Aurora A regulation by the metabolic integrator coenzyme A
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells
Foulkes, D. M., Byrne, D. P., Yeung, W., Shrestha, S., Bailey, F. P., Ferries, S., . . . Eyers, P. A. (2018). Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells. SCIENCE SIGNALING, 11(549), 14 pages. doi:10.1126/scisignal.aat7951
New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors
Byrne, D. P., Li, Y., Ramakrishnan, K., Barsukov, I. L., Yates, E. A., Eyers, C. E., . . . Eyers, P. A. (2018). New tools for carbohydrate sulfation analysis: heparan sulfate 2-O-sulfotransferase (HS2ST) is a target for small-molecule protein kinase inhibitors. BIOCHEMICAL JOURNAL, 475(15), 2417-2433. doi:10.1042/BCJ20180265
New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors
Byrne, D. P., Li, Y., Ngamlert, P., Ramakrishnan, K., Eyers, C. E., Wells, C., . . . Eyers, P. A. (2018). New tools for evaluating protein tyrosine sulfation: tyrosylprotein sulfotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors. BIOCHEMICAL JOURNAL, 475(15), 2435-2455. doi:10.1042/BCJ20180266
PO-061 BCL-2 family of proteins, BCL-XL and MCL-1, regulate apoptosis and cancer cell survival by different mechanisms
Greaves, G., Milani, M., Byrne, D., Carter, R., Butterworth, M., Luo, X., . . . Varadarajan, S. (2018). PO-061 BCL-2 family of proteins, BCL-XL and MCL-1, regulate apoptosis and cancer cell survival by different mechanisms. ESMO Open, 3, A44-A45. doi:10.1136/esmoopen-2018-eacr25.105
Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint
Combes, G., Barysz, H., Garand, C., Braga, L. G., Alharbi, I., Thebault, P., . . . Elowe, S. (2018). Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint. CURRENT BIOLOGY, 28(6), 872-883. doi:10.1016/j.cub.2018.02.002
Autophosphorylation is a mechanism of inhibition in twitchin kinase
Williams, R., Franke, B., Wilkinson, M., Fleming, J., Rigden, D. J., Benian, G., . . . Mayans, O. (2018). Autophosphorylation is a mechanism of inhibition in twitchin kinase. Journal of Molecular Biology, 430(6), 793-805. doi:10.1016/j.jmb.2018.01.020
Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2
O'Connor, C., Yalla, K., Salomé, M., Moka, H. A., Castañeda, E. G., Eyers, P. A., & Keeshan, K. (2018). Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2.. Oncotarget, 9(19), 14977-14992. doi:10.18632/oncotarget.24525
Kinome‐wide transcriptional profiling of uveal melanoma reveals new vulnerabilities to targeted therapeutics
Bailey, F. P., Clarke, K., Kalirai, H., Kenyani, J., Shahidipour, H., Falciani, F., . . . Eyers, P. A. (2018). Kinome‐wide transcriptional profiling of uveal melanoma reveals new vulnerabilities to targeted therapeutics. Pigment Cell and Melanoma Research, 31(2), 253-266. doi:10.1111/pcmr.12650
Understanding protein-drug interactions using ion mobility-mass spectrometry
Eyers, C. E., Vonderach, M., Ferries, S., Jeacock, K., & Eyers, P. A. (2018). Understanding protein-drug interactions using ion mobility-mass spectrometry. CURRENT OPINION IN CHEMICAL BIOLOGY, 42, 167-176. doi:10.1016/j.cbpa.2017.12.013
Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease
Eyers, P. A. (2018). Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease. BIOCHEMICAL JOURNAL, 475, 185-189. doi:10.1042/BCJ20170870
New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome
Wilson, L. J., Linley, A., Hammond, D. E., Hood, F. E., Coulson, J. M., MacEwan, D. J., . . . Prior, I. A. (2018). New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome. CANCER RESEARCH, 78(1), 15-29. doi:10.1158/0008-5472.CAN-17-2291
2017
Live and let die: insights into pseudoenzyme mechanisms from structure
Murphy, J. M., Mace, P. D., & Eyers, P. A. (2017). Live and let die: insights into pseudoenzyme mechanisms from structure. CURRENT OPINION IN STRUCTURAL BIOLOGY, 47, 95-104. doi:10.1016/j.sbi.2017.07.004
Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes
Bury, L., Coelho, P. A., Simeone, A., Ferries, S., Eyers, C. E., Eyers, P. A., . . . Glover, D. M. (2017). Plk4 and Aurora A cooperate in the initiation of acentriolar spindle assembly in mammalian oocytes. JOURNAL OF CELL BIOLOGY, 216(11), 3571-3590. doi:10.1083/jcb.201606077
Evaluation of Parameters for Confident Phosphorylation Site Localization using an Orbitrap Fusion Tribrid Mass Spectrometer
Ferries., Perkins, S., Brownridge., Campbell, A., Eyers, P., Jones, A., & Eyers, C. E. (2017). Evaluation of Parameters for Confident Phosphorylation Site Localization using an Orbitrap Fusion Tribrid Mass Spectrometer. Journal of Proteome Research, 16(9), 3448-3459. doi:10.1021/acs.jproteome.7b00337
Local protein kinase A action proceeds through intact holoenzymes
Smith, F. D., Esseltine, J. L., Nygren, P. J., Veesler, D., Byrne, D. P., Vonderach, M., . . . Scott, J. D. (2017). Local protein kinase A action proceeds through intact holoenzymes. Science, 356(6344), 1288-1293. doi:10.1126/science.aaj1669
Bio-Zombie: the rise of pseudoenzymes in biology
Murphy, J. M., Farhan, H., & Eyers, P. A. (2017). Bio-Zombie: the rise of pseudoenzymes in biology. BIOCHEMICAL SOCIETY TRANSACTIONS, 45, 537-544. doi:10.1042/BST20160400
Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease.
Eyers, P. A., Keeshan, K., & Kannan, N. (2017). Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease. TRENDS IN CELL BIOLOGY, 27(4), 284-298. doi:10.1016/j.tcb.2016.11.002
Pseudokinases: update on their functions and evaluation as new drug targets
Byrne, D. P., Foulkes, D. M., & Eyers, P. A. (2017). Pseudokinases: update on their functions and evaluation as new drug targets. FUTURE MEDICINAL CHEMISTRY, 9(2), 245-265. doi:10.4155/fmc-2016-0207
DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis
Milani, M., Byrne, D. P., Greaves, G., Butterworth, M., Cohen, G. M., Eyers, P. A., & Varadarajan, S. (2018). DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis. Cell Death and Disease, 8. doi:10.1038/cddis.2016.485
The response of uveal melanoma (UM) cells to Bromodomain and Extra Terminal (BET) inhibitors
Bailey, F. P., Kalirai, H., Shahidipour, H., Clarke, K., Coupland, S. E., & Eyers, P. A. (2017). The response of uveal melanoma (UM) cells to Bromodomain and Extra Terminal (BET) inhibitors. In INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE Vol. 58. Retrieved from https://www.webofscience.com/
2016
Mitotic phosphotyrosine network analysis reveals that tyrosine phosphorylation regulates Polo-like kinase 1 (PLK1)
Caron, D., Byrne, D. P., Thebault, P., Soulet, D., Landry, C. R., Eyers, P. A., & Elowe, S. (2016). Mitotic phosphotyrosine network analysis reveals that tyrosine phosphorylation regulates Polo-like kinase 1 (PLK1). SCIENCE SIGNALING, 9(458). doi:10.1126/scisignal.aah3525
KinView: A visual comparative sequence analysis tool for integrated kinome research
Skimming, D., Dastgheib, S., Baffi, T., Byrne, D., Ferries, S., Scott, S., . . . Kannan, N. (2016). KinView: A visual comparative sequence analysis tool for integrated kinome research. Molecular BioSystems, (12), 3651-3665. doi:10.1039/C6MB00466K
The evolving world of pseudoenzymes: proteins, prejudice and zombies
Eyers, P. A., & Murphy, J. M. (2016). The evolving world of pseudoenzymes: proteins, prejudice and zombies. BMC BIOLOGY, 14. doi:10.1186/s12915-016-0322-x
Human CDK18 promotes replication stress signaling and genome stability
Barone, G., Staples, C., Ganesh, A., Patterson, K., Byrne, D., Myers, K., . . . Collis, S. (2016). Human CDK18 promotes replication stress signaling and genome stability. Nucleic Acids Research, 44(18), 8772-8785. doi:10.1093/nar/gkw615
cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry
Byrne, D. P., Vonderach, M., Ferries, S., Brownridge, P. J., Eyers, C. E., & Eyers, P. A. (2016). cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry. BIOCHEMICAL JOURNAL, 473, 3159-3175. doi:10.1042/BCJ20160648
'Up with the LRRK': a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement
Eyers, P. A. (2016). 'Up with the LRRK': a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement. BIOCHEMICAL JOURNAL, 473, 2757-2762. doi:10.1042/BCJ20160671C
The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth
Bago, R., Sommer, E., Castel, P., Crafter, C., Bailey, F. P., Shpiro, N., . . . Alessi, D. R. (2016). The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth. EMBO JOURNAL, 35(17), 1902-1922. doi:10.15252/embj.201693929
Human TRIB2 Oscillates during the Cell Cycle and Promotes Ubiquitination and Degradation of CDC25C
Liang, K. L., Paredes, R., Carmody, R., Eyers, P. A., Meyer, S., McCarthy, T. V., & Keeshan, K. (2016). Human TRIB2 Oscillates during the Cell Cycle and Promotes Ubiquitination and Degradation of CDC25C. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 17(9). doi:10.3390/ijms17091378
Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.
Mohanty, S., Oruganty, K., Kwon, A., Byrne, D., Ferries, S., Ruan, Z., . . . Kannan, N. (2016). Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization.. PLoS Genetics, 12(2). doi:10.1371/journal.pgen.1005885
2015
TRIBBLES: A Twist in the Pseudokinase Tail
Eyers, P. A. (2015). TRIBBLES: A Twist in the Pseudokinase Tail. STRUCTURE, 23(11), 1974-1976. doi:10.1016/j.str.2015.10.003
Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes centrin 2 function
Sawant, D. B., Majumder, S., Perkins, J. L., Yang, C. -H., Eyers, P. A., & Fisk, H. A. (2015). Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes centrin 2 function. MOLECULAR BIOLOGY OF THE CELL, 26(21), 3741-3753. doi:10.1091/mbc.E14-07-1248
Tribbles pseudokinases: novel targets for chemical biology and drug discovery?
Foulkes, D. M., Byrne, D. P., Bailey, F. P., & Eyers, P. A. (2015). Tribbles pseudokinases: novel targets for chemical biology and drug discovery?. BIOCHEMICAL SOCIETY TRANSACTIONS, 43, 1095-1103. doi:10.1042/BST20150109
TD-60 links RalA GTPase function to the CPC in mitosis
Papini, D., Langemeyer, L., Abad, M. A., Kerr, A., Samejima, I., Eyers, P. A., . . . Earnshaw, W. C. (2015). TD-60 links RalA GTPase function to the CPC in mitosis. NATURE COMMUNICATIONS, 6. doi:10.1038/ncomms8678
The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner
Bailey, F., Byrne, D., Oruganty, K., Eyers, C., Novotny, C. J., Shokat, K. M., . . . Eyers, P. (2015). The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner. Biochemical Journal, 467(1), 47-62. doi:10.1042/BJ20141441
2) Going for broke: targeting the human cancer pseudokinome.
Bailey, F. P., Byrne, D. P., McSkimming, D., Kannan, N., & Eyers, P. A. (2015). 2) Going for broke: targeting the human cancer pseudokinome.. The Biochemical journal, 466(1), 201. doi:10.1042/bj4660201v
Going for broke: targeting the human cancer pseudokinome
Bailey, F. P., Byrne, D. P., McSkimming, D., Kannan, N., & Eyers, P. A. (2015). Going for broke: targeting the human cancer pseudokinome. BIOCHEMICAL JOURNAL, 465, 195-211. doi:10.1042/BJ20141060
Going for broke: targeting the human cancer pseudokinome (vol 465, pg 195, 2015)
Bailey, F. P., Byrne, D. P., McSkimming, D., Kannan, N., & Eyers, P. A. (2015). Going for broke: targeting the human cancer pseudokinome (vol 465, pg 195, 2015). BIOCHEMICAL JOURNAL, 466, 201. Retrieved from https://www.webofscience.com/
2014
DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B.
Zuazua-Villar, P., Rodriguez, R., Gagou, M. E., Eyers, P., & Meuth, M. (2014). DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B.. Cell Death and Disease, 5. doi:10.1038/cddis.2014.231
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.
Murphy, J. M., Zhang, Q., Young, S. N., Reese, M. L., Bailey, F., Eyers, P., . . . Lucet, I. S. (2014). A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.. The Biochemical Journal, 457(2), 323-334. doi:10.1042/BJ20131174
Day of the dead: pseudokinases and pseudophosphatases in physiology and disease
Reiterer, V., Eyers, P. A., & Farhan, H. (2014). Day of the dead: pseudokinases and pseudophosphatases in physiology and disease. TRENDS IN CELL BIOLOGY, 24(9), 489-505. doi:10.1016/j.tcb.2014.03.008
The Resistance Tetrad: Amino Acid Hotspots for Kinome-Wide Exploitation of Drug-Resistant Protein Kinase Alleles
Bailey, F. P., Andreev, V. I., & Eyers, P. A. (2014). The Resistance Tetrad: Amino Acid Hotspots for Kinome-Wide Exploitation of Drug-Resistant Protein Kinase Alleles. PROTEIN KINASE INHIBITORS IN RESEARCH AND MEDICINE, 548, 117-146. doi:10.1016/B978-0-12-397918-6.00005-7
2013
Elucidation and Therapeutic Targeting Of The Molecular Mechanism Of TRIB2-Mediated Acute Myeloid Leukaemia
Lohan, F., Forde, C., Salome, M., O'Connor, C., Bailey, F., Cahill, M. R., . . . Keeshan, K. (2013). Elucidation and Therapeutic Targeting Of The Molecular Mechanism Of TRIB2-Mediated Acute Myeloid Leukaemia. Blood, 122(21), 3792. doi:10.1182/blood.v122.21.3792.3792
Elucidation and Therapeutic Targeting Of The Molecular Mechanism Of TRIB2-Mediated Acute Myeloid Leukaemia
Lohan, F., Forde, C., Salome, M., O'Connor, C., Bailey, F., Cahill, M. R., . . . Keeshan, K. (2013). Elucidation and Therapeutic Targeting Of The Molecular Mechanism Of TRIB2-Mediated Acute Myeloid Leukaemia. Blood, 122(21), 3799. doi:10.1182/blood.v122.21.3799.3799
Dawn of the dead: protein pseudokinases signal new adventures in cell biology.
Eyers, P. A., & Murphy, J. M. (2013). Dawn of the dead: protein pseudokinases signal new adventures in cell biology.. Biochemical Society transactions, 41(4), 969-974. doi:10.1042/bst20130115
Rheostat-ing mitosis.
Eyers, P. A. (2013). Rheostat-ing mitosis.. Chemistry & biology, 20(2), 142-143. doi:10.1016/j.chembiol.2013.02.001
A robust methodology to subclassify pseudokinases based on their nucleotide binding properties
Murphy, J. E. A. (2013). A robust methodology to subclassify pseudokinases based on their nucleotide binding properties. Biochemical Journal. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/24107129
Getting to grips with drug-resistance in the human protein kinase superfamily
Eyers, P. A. (2013). Getting to grips with drug-resistance in the human protein kinase superfamily. European Pharmaceutical Review, 18, 49-54.
2012
A framework for identification of actionable cancer genome dependencies in small cell lung cancer.
Sos, M. L., Dietlein, F., Peifer, M., Schöttle, J., Balke-Want, H., Müller, C., . . . Thomas, R. K. (2012). A framework for identification of actionable cancer genome dependencies in small cell lung cancer.. Proceedings of the National Academy of Sciences of the United States of America, 109(42), 17034-17039. doi:10.1073/pnas.1207310109
2011
Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.
Hégarat, N., Smith, E., Nayak, G., Takeda, S., Eyers, P. A., & Hochegger, H. (2011). Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.. The Journal of cell biology, 195(7), 1103-1113. doi:10.1083/jcb.201105058
Protein kinase A is central for forward transport of two-pore domain potassium channels K2P3.1 and K2P9.1.
Mant, A., Elliott, D., Eyers, P. A., & O'Kelly, I. M. (2011). Protein kinase A is central for forward transport of two-pore domain potassium channels K2P3.1 and K2P9.1.. The Journal of biological chemistry, 286(16), 14110-14119. doi:10.1074/jbc.m110.190702
Aurora A and Aurora B jointly coordinate chromosome segregation
Hegarat, N., Smith, E., Nayak, G., Takeda, S., Eyers, P. A., & Hochegger, H. (2011). Aurora A and Aurora B jointly coordinate chromosome segregation. J Cell Biol, 195, 1103-1113.
Phosphorylation by Protein Kinase A (PKA) enables forward transport of K2P3.1 and K2P9.1, two pore domain potassium channels
Mant, A., Elliott, D., Eyers, P., & O'Kelly, I. M. (2011). Phosphorylation by Protein Kinase A (PKA) enables forward transport of K2P3.1 and K2P9.1, two pore domain potassium channels. J Biol Chem, 286, 14110-14119.
2010
Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237.
Sloane, D. A., Trikic, M. Z., Chu, M. L. H., Lamers, M. B. A. C., Mason, C. S., Mueller, I., . . . Eyers, P. A. (2010). Drug-resistant aurora A mutants for cellular target validation of the small molecule kinase inhibitors MLN8054 and MLN8237.. ACS chemical biology, 5(6), 563-576. doi:10.1021/cb100053q
Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.
Chu, M. L. H., Lang, Z., Chavas, L. M. G., Neres, J., Fedorova, O. S., Tabernero, L., . . . Eyers, P. A. (2010). Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes.. Biochemistry, 49(8), 1689-1701. doi:10.1021/bi901970c
2009
Rigorous determination of the stoichiometry of protein phosphorylation using mass spectrometry
Johnson, H., Eyers, C. E., Eyers, P. A., Beynon, R. J., & Gaskell, S. J. (2009). Rigorous determination of the stoichiometry of protein phosphorylation using mass spectrometry. Journal of the American Society for Mass Spectrometry, 20(12), 2211-2220. doi:10.1016/j.jasms.2009.08.009
Discovery and exploitation of inhibitor-resistant aurora and polo kinase mutants for the analysis of mitotic networks.
Scutt, P. J., Chu, M. L. H., Sloane, D. A., Cherry, M., Bignell, C. R., Williams, D. H., & Eyers, P. A. (2009). Discovery and exploitation of inhibitor-resistant aurora and polo kinase mutants for the analysis of mitotic networks.. The Journal of biological chemistry, 284(23), 15880-15893. doi:10.1074/jbc.m109.005694
Survivin(g) phosphorylation?
Eyers, P. (2009). Survivin(g) phosphorylation?. Cell cycle (Georgetown, Tex.), 8(2), 183-184. doi:10.4161/cc.8.2.7828
Phosphoregulation of human Mps1 kinase.
Tyler, R. K., Chu, M. L. H., Johnson, H., McKenzie, E. A., Gaskell, S. J., & Eyers, P. A. (2009). Phosphoregulation of human Mps1 kinase.. The Biochemical journal, 417(1), 173-181. doi:10.1042/bj20081310
2008
Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125.
Chu, M. L. H., Chavas, L. M. G., Douglas, K. T., Eyers, P. A., & Tabernero, L. (2008). Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125.. The Journal of biological chemistry, 283(31), 21495-21500. doi:10.1074/jbc.m803026200
Spindle pole regulation by a discrete Eg5-interacting domain in TPX2.
Eckerdt, F., Eyers, P. A., Lewellyn, A. L., Prigent, C., & Maller, J. L. (2008). Spindle pole regulation by a discrete Eg5-interacting domain in TPX2.. Current biology : CB, 18(7), 519-525. doi:10.1016/j.cub.2008.02.077
2007
VX-680 inhibits Aurora A and Aurora B kinase activity in human cells.
Tyler, R. K., Shpiro, N., Marquez, R., & Eyers, P. A. (2007). VX-680 inhibits Aurora A and Aurora B kinase activity in human cells.. Cell cycle (Georgetown, Tex.), 6(22), 2846-2854. doi:10.4161/cc.6.22.4940
2006
Validating Aurora B as an anti-cancer drug target.
Girdler, F., Gascoigne, K. E., Eyers, P. A., Hartmuth, S., Crafter, C., Foote, K. M., . . . Taylor, S. S. (2006). Validating Aurora B as an anti-cancer drug target.. Journal of cell science, 119(Pt 17), 3664-3675. doi:10.1242/jcs.03145
2005
Reduction of insulin-stimulated glucose uptake in L6 myotubes by the protein kinase inhibitor SB203580 is independent of p38MAPK activity.
Antonescu, C. N., Huang, C., Niu, W., Liu, Z., Eyers, P. A., Heidenreich, K. A., . . . Klip, A. (2005). Reduction of insulin-stimulated glucose uptake in L6 myotubes by the protein kinase inhibitor SB203580 is independent of p38MAPK activity.. Endocrinology, 146(9), 3773-3781. doi:10.1210/en.2005-0404
Regulation of the G(2)/M transition in Xenopus oocytes by the cAMP-dependent protein kinase.
Eyers, P. A., Liu, J., Hayashi, N. R., Lewellyn, A. L., Gautier, J., & Maller, J. L. (2005). Regulation of the G(2)/M transition in Xenopus oocytes by the cAMP-dependent protein kinase.. The Journal of biological chemistry, 280(26), 24339-24346. doi:10.1074/jbc.m412442200
The Aurora A and Aurora B protein kinases: a single amino acid difference controls intrinsic activity and activation by TPX2.
Eyers, P. A., Churchill, M. E. A., & Maller, J. L. (2005). The Aurora A and Aurora B protein kinases: a single amino acid difference controls intrinsic activity and activation by TPX2.. Cell cycle (Georgetown, Tex.), 4(6), 784-789. doi:10.4161/cc.4.6.1693
2004
Regulation of Xenopus Aurora A activation by TPX2.
Eyers, P. A., & Maller, J. L. (2004). Regulation of Xenopus Aurora A activation by TPX2.. The Journal of biological chemistry, 279(10), 9008-9015. doi:10.1074/jbc.m312424200
2003
Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest.
Tunquist, B. J., Eyers, P. A., Chen, L. G., Lewellyn, A. L., & Maller, J. L. (2003). Spindle checkpoint proteins Mad1 and Mad2 are required for cytostatic factor-mediated metaphase arrest.. The Journal of cell biology, 163(6), 1231-1242. doi:10.1083/jcb.200306153
Regulating the regulators: Aurora A activation and mitosis.
Eyers, P. A., & Maller, J. L. (2003). Regulating the regulators: Aurora A activation and mitosis.. Cell cycle (Georgetown, Tex.), 2(4), 287-289.
A novel mechanism for activation of the protein kinase Aurora A.
Eyers, P. A., Erikson, E., Chen, L. G., & Maller, J. L. (2003). A novel mechanism for activation of the protein kinase Aurora A.. Current biology : CB, 13(8), 691-697. doi:10.1016/s0960-9822(03)00166-0
Identification of novel phosphorylation sites on <i>Xenopus laevis</i> aurora A and analysis of phosphopeptide enrichment by immobilized metal-affinity chromatography
Haydon, C. E., Eyers, P. A., Aveline-Wolf, L. D., Resing, K. A., Maller, J. L., & Ahn, N. G. (2003). Identification of novel phosphorylation sites on <i>Xenopus laevis</i> aurora A and analysis of phosphopeptide enrichment by immobilized metal-affinity chromatography. MOLECULAR & CELLULAR PROTEOMICS, 2(10), 1055-1067. doi:10.1074/mcp.M300054-MCP200