Research outputs
Selected research outputs
- How are hydrogen peroxide messages relayed to affect cell signalling? (Journal article - 2024)
- Proteome-wide Tagging With Genetically Encoded Biosensors To Identify Highly Localised Oxidation Events (Journal article - 2023)
- Tolerance to nascent protein misfolding stress requires fine-tuning of the cAMP/PKA pathway (Journal article - 2021)
- Endoplasmic reticulum (ER) stress-induced reactive oxygen species (ROS) are detrimental for the fitness of a thioredoxin reductase mutant (Journal article - 2018)
- Unconventional Targeting of a Thiol Peroxidase to the Mitochondrial Intermembrane Space Facilitates Oxidative Protein Folding (Journal article - 2017)
2025
Utilising tethered biosensors to uncover intracellular redox heterogeneity
Kritsiligkou, P. (2025). Utilising tethered biosensors to uncover intracellular redox heterogeneity. Free Radical Biology and Medicine, 240, S67. doi:10.1016/j.freeradbiomed.2025.10.193
2024
Evidence-based sports supplements: A redox analysis.
Margaritelis, N. V., Cobley, J. N., Nastos, G. G., Papanikolaou, K., Bailey, S. J., Kritsiligkou, P., & Nikolaidis, M. G. (2024). Evidence-based sports supplements: A redox analysis.. Free radical biology & medicine, 224, 62-77. doi:10.1016/j.freeradbiomed.2024.08.012
How are hydrogen peroxide messages relayed to affect cell signalling?
Veal, E. A., & Kritsiligkou, P. (2024). How are hydrogen peroxide messages relayed to affect cell signalling?. CURRENT OPINION IN CHEMICAL BIOLOGY, 81. doi:10.1016/j.cbpa.2024.102496
2023
Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways
Denolly, S., Stukalov, A., Barayeu, U., Rosinski, A. N., Kritsiligkou, P., Joecks, S., . . . Bartenschlager, R. (2023). Zika virus remodelled ER membranes contain proviral factors involved in redox and methylation pathways. NATURE COMMUNICATIONS, 14(1). doi:10.1038/s41467-023-43665-6
From workout to molecular switches: How does skeletal muscle produce, sense, and transduce subcellular redox signals?
Henriquez-Olguin, C., Meneses-Valdes, R., Kritsiligkou, P., & Fuentes-Lemus, E. (2023). From workout to molecular switches: How does skeletal muscle produce, sense, and transduce subcellular redox signals?. FREE RADICAL BIOLOGY AND MEDICINE, 209, 355-365. doi:10.1016/j.freeradbiomed.2023.10.404
Proteome-wide Tagging With Genetically Encoded Biosensors To Identify Highly Localised Oxidation Events
Kritsiligkou, P., Bosch, K., & Dick, T. (2023). Proteome-wide Tagging With Genetically Encoded Biosensors To Identify Highly Localised Oxidation Events. Free Radical Biology and Medicine, 208, S21. doi:10.1016/j.freeradbiomed.2023.10.048
Paralogous translation factors target distinct mRNAs to differentially regulate tolerance to oxidative stress in yeast
Cunningham, J., Sfakianos, A. P., Kritsiligkou, P., Kershaw, C. J., Whitmarsh, A. J., Hubbard, S. J., . . . Grant, C. M. (2023). Paralogous translation factors target distinct mRNAs to differentially regulate tolerance to oxidative stress in yeast. NUCLEIC ACIDS RESEARCH, 51(16), 8820-8835. doi:10.1093/nar/gkad568
Proteome wide tagging to identify highly localised oxidation events
Kritsiligkou, P., Bosch, K., & Dick, T. P. (2023). Proteome wide tagging to identify highly localised oxidation events. Free Radical Biology and Medicine, 201, 32. doi:10.1016/j.freeradbiomed.2023.03.132
Methionine Sulfoxide Reductases Suppress the Formation of the [<i>PSI</i><SUP>+</SUP>] Prion and Protein Aggregation in Yeast
Schepers, J., Carter, Z., Kritsiligkou, P., & Grant, C. M. (2023). Methionine Sulfoxide Reductases Suppress the Formation of the [<i>PSI</i><SUP>+</SUP>] Prion and Protein Aggregation in Yeast. ANTIOXIDANTS, 12(2). doi:10.3390/antiox12020401
Proteome-wide tagging with an H2O2 biosensor reveals highly localized and dynamic redox microenvironments
Kritsiligkou, P., Bosch, K., Shen, T. K., Meurer, M., Knop, M., & Dick, T. P. (2023). Proteome-wide tagging with an H2O2 biosensor reveals highly localized and dynamic redox microenvironments. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 120(48). doi:10.1073/pnas.2314043120
2022
Molecular determinants of dynamic protein-protein interactions in the functional cycle of the membrane protein DsbD
2021
A comparison of Prx- and OxyR-based H<sub>2</sub>O<sub>2</sub> probes expressed in <i>S. cerevisiae</i>
Kritsiligkou, P., Shen, T. K., & Dick, T. P. (2021). A comparison of Prx- and OxyR-based H<sub>2</sub>O<sub>2</sub> probes expressed in <i>S. cerevisiae</i>. JOURNAL OF BIOLOGICAL CHEMISTRY, 297(1). doi:10.1016/j.jbc.2021.100866
Towards inclusive funding practices for early career researchers
de Winde, C. M., Sarabipour, S., Carignano, H., Davla, S., Eccles, D., Hainer, S. J., . . . Ólafsdóttir, H. F. (2021). Towards inclusive funding practices for early career researchers. Journal of Science Policy & Governance, 18(01). doi:10.38126/jspg180105
Tolerance to nascent protein misfolding stress requires fine-tuning of the cAMP/PKA pathway
Kritsiligkou, P., Nowicki-Osuch, K., Carter, Z., Kershaw, C. J., Creamer, D. R., Weids, A. J., & Grant, C. M. (2021). Tolerance to nascent protein misfolding stress requires fine-tuning of the cAMP/PKA pathway. JOURNAL OF BIOLOGICAL CHEMISTRY, 296. doi:10.1016/j.jbc.2021.100690
2018
Loss of mRNA surveillance pathways results in widespread protein aggregation
Jamar, N. H., Kritsiligkou, P., & Grant, C. M. (2018). Loss of mRNA surveillance pathways results in widespread protein aggregation. SCIENTIFIC REPORTS, 8. doi:10.1038/s41598-018-22183-2
The mTOR-S6 kinase pathway promotes stress granule assembly
Sfakianos, A. P., Mellor, L. E., Pang, Y. F., Kritsiligkou, P., Needs, H., Abou-Hamdan, H., . . . Whitmarsh, A. J. (2018). The mTOR-S6 kinase pathway promotes stress granule assembly. CELL DEATH AND DIFFERENTIATION, 25(10), 1766-1780. doi:10.1038/s41418-018-0076-9
Endoplasmic reticulum (ER) stress-induced reactive oxygen species (ROS) are detrimental for the fitness of a thioredoxin reductase mutant
Kritsiligkou, P., Rand, J. D., Weids, A. J., Wang, X., Kershaw, C. J., & Grant, C. M. (2018). Endoplasmic reticulum (ER) stress-induced reactive oxygen species (ROS) are detrimental for the fitness of a thioredoxin reductase mutant. JOURNAL OF BIOLOGICAL CHEMISTRY, 293(31), 11984-11995. doi:10.1074/jbc.RA118.001824
2017
The non-stop decay mRNA surveillance pathway is required for oxidative stress tolerance
Jamar, N. H., Kritsiligkou, P., & Grant, C. M. (2017). The non-stop decay mRNA surveillance pathway is required for oxidative stress tolerance. NUCLEIC ACIDS RESEARCH, 45(11), 6881-6893. doi:10.1093/nar/gkx306
Unconventional Targeting of a Thiol Peroxidase to the Mitochondrial Intermembrane Space Facilitates Oxidative Protein Folding
Kritsiligkou, P., Chatzi, A., Charalampous, G., Mironov, A. J., Grant, C. M., & Tokatlidis, K. (2017). Unconventional Targeting of a Thiol Peroxidase to the Mitochondrial Intermembrane Space Facilitates Oxidative Protein Folding. CELL REPORTS, 18(11), 2729-2741. doi:10.1016/j.celrep.2017.02.053
ER stress causes widespread protein aggregation and prion formation
Hamdan, N., Kritsiligkou, P., & Grant, C. M. (2017). ER stress causes widespread protein aggregation and prion formation. JOURNAL OF CELL BIOLOGY, 216(8), 2295-2304. doi:10.1083/jcb.201612165
2014
An Extended Active-site Motif Controls the Reactivity of the Thioredoxin Fold
Mavridou, D. A. I., Saridakis, E., Kritsiligkou, P., Mozley, E. C., Ferguson, S. J., & Redfield, C. (2014). An Extended Active-site Motif Controls the Reactivity of the Thioredoxin Fold. JOURNAL OF BIOLOGICAL CHEMISTRY, 289(12), 8681-8696. doi:10.1074/jbc.M113.513457
2013
Amputation-induced reactive oxygen species are required for successful <i>Xenopus</i> tadpole tail regeneration
Love, N. R., Chen, Y., Ishibashi, S., Kritsiligkou, P., Lea, R., Koh, Y., . . . Amaya, E. (2013). Amputation-induced reactive oxygen species are required for successful <i>Xenopus</i> tadpole tail regeneration. NATURE CELL BIOLOGY, 15(2), 222-228. doi:10.1038/ncb2659
Oxidation of the Yeast Mitochondrial Thioredoxin Promotes Cell Death
Greetham, D., Kritsiligkou, P., Watkins, R. H., Carter, Z., Parkin, J., & Grant, C. M. (2013). Oxidation of the Yeast Mitochondrial Thioredoxin Promotes Cell Death. ANTIOXIDANTS & REDOX SIGNALING, 18(4), 376-385. doi:10.1089/ars.2012.4597
2012
Targeting and Maturation of Erv1/ALR in the Mitochondrial Intermembrane Space
Kallergi, E., Andreadaki, M., Kritsiligkou, P., Katrakili, N., Pozidis, C., Tokatlidis, K., . . . Peruzzini, R. (2012). Targeting and Maturation of Erv1/ALR in the Mitochondrial Intermembrane Space. ACS CHEMICAL BIOLOGY, 7(4), 707-714. doi:10.1021/cb200485b
2011
Cytochrome c biogenesis System I
Stevens, J. M., Mavridou, D. A. I., Hamer, R., Kritsiligkou, P., Goddard, A. D., & Ferguson, S. J. (2011). Cytochrome c biogenesis System I. FEBS JOURNAL, 278(22), 4170-4178. doi:10.1111/j.1742-4658.2011.08376.x
Reduced nDsbD sheds light on protein-protein interactions in disulfide cascades
Saridakis, E., Mavridou, D. A. I., Kritsiligkou, P., Goddard, A. D., Stevens, J. M., Ferguson, S. J., & Redfield, C. (2011). Reduced nDsbD sheds light on protein-protein interactions in disulfide cascades. Acta Crystallographica Section A Foundations of Crystallography, 67(a1), C350. doi:10.1107/s0108767311091197
Oxidation State-dependent Protein-Protein Interactions in Disulfide Cascades
Mavridou, D. A. I., Saridakis, E., Kritsiligkou, P., Goddard, A. D., Stevens, J. M., Ferguson, S. J., & Redfield, C. (2011). Oxidation State-dependent Protein-Protein Interactions in Disulfide Cascades. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(28), 24943-24956. doi:10.1074/jbc.M111.236141