Research outputs
2026
Uncovering the multifaceted mechanism of action of a historical antimicrobial
2024
S42 Pseudomonas aeruginosa genetic variants associated with increased exacerbations in bronchiectasis
Hull, R. C., Harrington, N., Gilmour, A., Long, M. B., Stobo, J., Kottara, A., . . . Chalmers, J. D. (2024). S42 Pseudomonas aeruginosa genetic variants associated with increased exacerbations in bronchiectasis. In ‘Where the Wild Things Are’ – Infection and inflammation in bronchiectasis and NTM (pp. A35-A36). BMJ Publishing Group Ltd and British Thoracic Society. doi:10.1136/thorax-2024-btsabstracts.48
Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance
Shepherd, M. J., Fu, T., Harrington, N. E., Kottara, A., Cagney, K., Chalmers, J. D., . . . Brockhurst, M. A. (2024). Ecological and evolutionary mechanisms driving within-patient emergence of antimicrobial resistance. Nature Reviews Microbiology. doi:10.1038/s41579-024-01041-1
Global genomic diversity of Pseudomonas aeruginosa in bronchiectasis
Harrington, N. E., Kottara, A., Cagney, K., Shepherd, M. J., Grimsey, E. M., Fu, T., . . . Paterson, S. (2024). Global genomic diversity of Pseudomonas aeruginosa in bronchiectasis. Journal of Infection, 106275. doi:10.1016/j.jinf.2024.106275
2023
Combining SNAPs with antibiotics shows enhanced synergistic efficacy against <i>S. aureus</i> and <i>P. aeruginosa</i> biofilms
Maset, R. G., Hapeshi, A., Lapage, J., Harrington, N., Littler, J., Perrier, S., & Harrison, F. (2023). Combining SNAPs with antibiotics shows enhanced synergistic efficacy against <i>S. aureus</i> and <i>P. aeruginosa</i> biofilms. NPJ BIOFILMS AND MICROBIOMES, 9(1). doi:10.1038/s41522-023-00401-8
Combining SNAPs with antibiotics shows enhanced synergistic efficacy against S. <i>aureus</i> and P. <i>aeruginosa</i> biofilms (vol 9, 36, 2023)
Maset, R. G., Hapeshi, A., Lapage, J., Harrington, N., Littler, J., Perrier, S., & Harrison, F. (2023). Combining SNAPs with antibiotics shows enhanced synergistic efficacy against S. <i>aureus</i> and P. <i>aeruginosa</i> biofilms (vol 9, 36, 2023). NPJ BIOFILMS AND MICROBIOMES, 9(1). doi:10.1038/s41522-023-00407-2
2022
How long does it take to cue a <i>Pseudomonas aeruginosa</i> chronic infection phenotype in the lab? Insights from transcriptome analysis in a cystic fibrosis lung model
Transcriptome Analysis of <i>Pseudomonas aeruginosa</i> Biofilm Infection in an <i>Ex Vivo</i> Pig Model of the Cystic Fibrosis Lung
Harrington, N. E., Littler, J. L., & Harrison, F. (2022). Transcriptome Analysis of <i>Pseudomonas aeruginosa</i> Biofilm Infection in an <i>Ex Vivo</i> Pig Model of the Cystic Fibrosis Lung. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 88(3). doi:10.1128/aem.01789-21
2021
Transcriptome analysis of <i>Pseudomonas aeruginosa</i> biofilm infection in an <i>ex vivo</i> pig model of the cystic fibrosis lung
Antibiotic Efficacy Testing in an Ex vivo Model of <em>Pseudomonas aeruginosa</em> and <em>Staphylococcus aureus</em> Biofilms in the Cystic Fibrosis Lung
Harrington, N. E., Sweeney, E., Alav, I., Allen, F., Moat, J., & Harrison, F. (2021). Antibiotic Efficacy Testing in an Ex vivo Model of <em>Pseudomonas aeruginosa</em> and <em>Staphylococcus aureus</em> Biofilms in the Cystic Fibrosis Lung. Journal of Visualized Experiments, (167). doi:10.3791/62187-v
Antibiotic Efficacy Testing in an Ex vivo Model of <i>Pseudomonas aeruginosa</i> and S<i>taphylococcus aureus</i> Biofilms in the Cystic Fibrosis Lung
Harrington, N. E., Sweeney, E., Alav, I., Allen, F., Moat, J., & Harrison, F. (2021). Antibiotic Efficacy Testing in an Ex vivo Model of <i>Pseudomonas aeruginosa</i> and S<i>taphylococcus aureus</i> Biofilms in the Cystic Fibrosis Lung. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (167). doi:10.3791/62187
An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection
Sweeney, E., Harrington, N. E., Henriques, A. G. H., Hassan, M. M., Crealock-Ashurst, B., Smyth, A. R., . . . Harrison, F. (2021). An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic Staphylococcus aureus infection. MICROBIOLOGY-SGM, 167(1). doi:10.1099/mic.0.000987
2020
Building a better biofilm - Formation of <i>in vivo</i>-like biofilm structures by <i>Pseudomonas aeruginosa</i> in a porcine model of cystic fibrosis lung infection.
Harrington, N. E., Sweeney, E., & Harrison, F. (2020). Building a better biofilm - Formation of <i>in vivo</i>-like biofilm structures by <i>Pseudomonas aeruginosa</i> in a porcine model of cystic fibrosis lung infection.. Biofilm, 2, 100024. doi:10.1016/j.bioflm.2020.100024
Predicting antibiotic-associated virulence of <i>Pseudomonas aeruginosa</i> using an <i>ex-vivo</i> lung biofilm model
Predicting Antibiotic-Associated Virulence of<i>Pseudomonas aeruginosa</i>Using an<i>ex vivo</i>Lung Biofilm Model
Hassan, M. M., Harrington, N. E., Sweeney, E., & Harrison, F. (2020). Predicting Antibiotic-Associated Virulence of<i>Pseudomonas aeruginosa</i>Using an<i>ex vivo</i>Lung Biofilm Model. FRONTIERS IN MICROBIOLOGY, 11. doi:10.3389/fmicb.2020.568510