Research outputs
Selected research outputs
- A Systematic Evaluation of IgM and IgG Antibody Assay Accuracy in Diagnosing Acute Zika Virus Infection in Brazil: Lessons Relevant to Emerging Infections (Journal article - 2021)
- Aetiology and outcome of non-traumatic coma in African children: protocol for a systematic review and meta-analysis (Journal article - 2021)
- Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study (Journal article - 2021)
- Neurological disease in adults with Zika and chikungunya virus infection in Northeast Brazil: a prospective observational study (Journal article - 2020)
- Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study (Journal article - 2018)
- Rapid Accurate Identification of Tuberculous Meningitis Among South African Children Using a Novel Clinical Decision Tool (Journal article - 2018)
- In Enterovirus 71 Encephalitis With Cardio-Respiratory Compromise, Elevated Interleukin 1 , Interleukin 1 Receptor Antagonist, and Granulocyte Colony-Stimulating Factor Levels Are Markers of Poor Prognosis (Journal article - 2012)
- Dissecting interferon-induced transcriptional programs in human peripheral blood cells. (Journal article - 2010)
- Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria (Journal article - 2008)
- Genomewide Analysis of the Host Response to Malaria in Kenyan Children (Journal article - 2005)
2025
The aetiologies, mortality, and disability of non-traumatic coma in African children: a systematic review and meta-analysis
Ray, S. T. J., Fuller, C. E., Boubour, A., Tshimangani, T., Kafoteka, E., Muiruri-Liomba, A., . . . Griffiths, M. J. (2025). The aetiologies, mortality, and disability of non-traumatic coma in African children: a systematic review and meta-analysis. The Lancet Global Health, 13(6), e1043-e1056. doi:10.1016/s2214-109x(25)00055-5
2024
Correction: Aetiology and Potential Animal Exposure in Central Nervous System Infections in Vietnam
Brindle, H. E., Nadjm, B., Choisy, M., Christley, R., Griffiths, M., Baker, S., . . . van Doorn, H. R. (2024). Correction: Aetiology and Potential Animal Exposure in Central Nervous System Infections in Vietnam. EcoHealth, 21(2-4), 210-212. doi:10.1007/s10393-022-01618-3
Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain
Dunai, C., Hetherington, C., Boardman, S. A., Clark, J. J., Sharma, P., Subramaniam, K., . . . Michael, B. D. (2024). Pulmonary SARS-CoV-2 infection leads to para-infectious immune activation in the brain. Frontiers in Immunology, 15. doi:10.3389/fimmu.2024.1440324
Reducing epilepsy diagnostic and treatment gaps: Standardized paediatric epilepsy training courses for health care professionals
Gifford, A., Griffiths, M. J., Rodie, P., Wilmshurst, J., Ball, J., Dunkley, C., . . . Kirkpatrick, M. (2024). Reducing epilepsy diagnostic and treatment gaps: Standardized paediatric epilepsy training courses for health care professionals. Developmental Medicine & Child Neurology, 66(8), 1045-1052. doi:10.1111/dmcn.15864
Paediatric meningitis in the conjugate vaccine era and a novel clinical decision model to predict bacterial aetiology
Martin, N. G., Defres, S., Willis, L., Beckley, R., Hardwick, H., Coxon, A., . . . Pollard, A. J. (2024). Paediatric meningitis in the conjugate vaccine era and a novel clinical decision model to predict bacterial aetiology. Journal of Infection, 88(5), 106145. doi:10.1016/j.jinf.2024.106145
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2024). Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 15(1). doi:10.1038/s41467-024-47320-6
Health economic impact of early versus delayed treatment of herpes simplex virus encephalitis in the UK
2023
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 14(1). doi:10.1038/s41467-023-42320-4
Specialist healthcare services for concussion/mild traumatic brain injury in England: a consensus statement using modified Delphi methodology.
Karvandi, E., Helmy, A., Kolias, A. G., Belli, A., Ganau, M., Gomes, C., . . . Hutchinson, P. J. (2023). Specialist healthcare services for concussion/mild traumatic brain injury in England: a consensus statement using modified Delphi methodology.. BMJ open, 13(12), e077022. doi:10.1136/bmjopen-2023-077022
Clinical predictors of encephalitis in UK adults-A multi-centre prospective observational cohort study.
Defres, S., Tharmaratnam, K., Michael, B. D., Ellul, M., Davies, N. W. S., Easton, A., . . . Solomon, T. (2023). Clinical predictors of encephalitis in UK adults-A multi-centre prospective observational cohort study.. PloS one, 18(8), e0282645. doi:10.1371/journal.pone.0282645
The spatio-temporal distribution of acute encephalitis syndrome and its association with climate and landcover in Vietnam.
Brindle, H. E., Bastos, L. S., Christley, R., Contamin, L., Dang, L. H., Anh, D. D., . . . Choisy, M. (2023). The spatio-temporal distribution of acute encephalitis syndrome and its association with climate and landcover in Vietnam.. BMC infectious diseases, 23(1), 403. doi:10.1186/s12879-023-08300-1
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Factors affecting ventriculoperitoneal shunt revision: a post hoc analysis of the British Antibiotic and Silver Impregnated Catheter Shunt multicenter randomized controlled trial
Sunderland, G. J., Conroy, E. J., Nelson, A., Gamble, C., Jenkinson, M. D., Griffiths, M. J., & Mallucci, C. L. (2023). Factors affecting ventriculoperitoneal shunt revision: a post hoc analysis of the British Antibiotic and Silver Impregnated Catheter Shunt multicenter randomized controlled trial. Journal of Neurosurgery, 138(2), 483-493. doi:10.3171/2022.4.jns22572
2022
Aetiology and Potential Animal Exposure in Central Nervous System Infections in Vietnam
Brindle, H. E., Nadjm, B., Choisy, M., Christley, R., Griffiths, M., Baker, S., . . . van Doorn, H. R. (2022). Aetiology and Potential Animal Exposure in Central Nervous System Infections in Vietnam. EcoHealth, 19(4), 463-474. doi:10.1007/s10393-022-01611-w
Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses
Needham, E. J., Ren, A. L., Digby, R. J., Norton, E. J., Ebrahimi, S., Outtrim, J. G., . . . Elmer, A. (2022). Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses. Brain, 145(11), 4097-4107. doi:10.1093/brain/awac321
Progressive myelin oligodendrocyte glycoprotein-associated demyelination mimicking leukodystrophy
Gibbons, E., Whittam, D., Elhadd, K., Bhojak, M., Rathi, N., Avula, S., . . . Huda, S. (2022). Progressive myelin oligodendrocyte glycoprotein-associated demyelination mimicking leukodystrophy. MULTIPLE SCLEROSIS JOURNAL, 28(9), 1481-1484. doi:10.1177/13524585221090737
Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19.
Palmos, A. B., Millischer, V., Menon, D. K., Nicholson, T. R., Taams, L. S., Michael, B., . . . Breen, G. (2022). Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19.. PLoS genetics, 18(3), e1010042. doi:10.1371/journal.pgen.1010042
Challenges for nurses in caring for patients with acute encephalitis: lack of knowledge, time and rehabilitation
Gill, C., Griffiths, M., Easton, A., & Solomon, T. (2022). Challenges for nurses in caring for patients with acute encephalitis: lack of knowledge, time and rehabilitation. British Journal of Nursing, 31(1), 40-45. doi:10.12968/bjon.2022.31.1.40
Viral capture sequencing detects unexpected viruses in the cerebrospinal fluid of adults with meningitis
McGill, F., Tokarz, R., Thomson, E. C., Filipe, A., Sameroff, S., Jain, K., . . . Solomon, T. (2022). Viral capture sequencing detects unexpected viruses in the cerebrospinal fluid of adults with meningitis. Journal of Infection. doi:10.1016/j.jinf.2021.12.042
2021
A Systematic Evaluation of IgM and IgG Antibody Assay Accuracy in Diagnosing Acute Zika Virus Infection in Brazil: Lessons Relevant to Emerging Infections
Griffiths, M. (2021). A Systematic Evaluation of IgM and IgG Antibody Assay Accuracy in Diagnosing Acute Zika Virus Infection in Brazil: Lessons Relevant to Emerging Infections. Journal of Clinical Microbiology.
Aetiology and outcome of non-traumatic coma in African children: protocol for a systematic review and meta-analysis
Ray, S. T. J., Fuller, C., Boubour, A., Bonnett, L. J., Lalloo, D. G., Seydel, K. B., & Griffiths, M. J. (2021). Aetiology and outcome of non-traumatic coma in African children: protocol for a systematic review and meta-analysis. SYSTEMATIC REVIEWS, 10(1). doi:10.1186/s13643-021-01796-1
Screening for cerebrovascular disorder on the basis of family history in asymptomatic children
Millward, C. P., Van Tonder, L., Williams, D., Thornton, O., Foster, M., Griffiths, M., . . . Mallucci, C. (2021). Screening for cerebrovascular disorder on the basis of family history in asymptomatic children. BRITISH JOURNAL OF NEUROSURGERY, 35(5), 584-590. doi:10.1080/02688697.2021.1922607
Protocol for DexEnceph: a randomised controlled trial of dexamethasone therapy in adults with herpes simplex virus encephalitis.
Whitfield, T., Fernandez, C., Davies, K., Defres, S., Griffiths, M., Hooper, C., . . . Solomon, T. (2021). Protocol for DexEnceph: a randomised controlled trial of dexamethasone therapy in adults with herpes simplex virus encephalitis.. BMJ open, 11(7), e041808. doi:10.1136/bmjopen-2020-041808
Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study
Ray, S. T. J., Abdel-Mannan, O., Sa, M., Fuller, C., Wood, G. K., Pysden, K., . . . Kneen, R. (2021). Neurological manifestations of SARS-CoV-2 infection in hospitalised children and adolescents in the UK: a prospective national cohort study. LANCET CHILD & ADOLESCENT HEALTH, 5(9), 631-641. doi:10.1016/S2352-4642(21)00193-0
Treatment of myelin oligodendrocyte glycoprotein immunoglobulin G–associated disease
Healy, S., Elhadd, K. T., Gibbons, E., Whittam, D., Griffiths, M., Jacob, A., & Huda, S. (2021). Treatment of myelin oligodendrocyte glycoprotein immunoglobulin G–associated disease. Clinical and Experimental Neuroimmunology, 12(1), 22-41. doi:10.1111/cen3.12630
Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study
Leonhard, S. E., Halstead, S., Lant, S. B., Militão de Albuquerque, M. D. F. P., de Brito, C. A. A., de Albuquerque, L. B. B., . . . Brito Ferreira, M. L. (2021). Guillain-Barré syndrome during the Zika virus outbreak in Northeast Brazil: An observational cohort study. Journal of the Neurological Sciences, 420, 117272. doi:10.1016/j.jns.2020.117272
Neurological and Psychiatric Manifestations of COVID-19 in UK Children: A Prospective National Cohort Study
Ray, S. T. J., Abdel-Mannan, O., Sa, M., Fuller, C., Wood, G. K., Psyden, K., . . . Group, C. S. (n.d.). Neurological and Psychiatric Manifestations of COVID-19 in UK Children: A Prospective National Cohort Study. SSRN Electronic Journal. doi:10.2139/ssrn.3844784
2020
TREM-1 activation is a potential key regulator in driving severe pathogenesis of enterovirus A71 infection
Amrun, S. N., Tan, J. J. L., Rickett, N. Y., Cox, J. A., Lee, B., Griffiths, M. J., . . . Ng, L. F. P. (2020). TREM-1 activation is a potential key regulator in driving severe pathogenesis of enterovirus A71 infection. Scientific Reports, 10(1). doi:10.1038/s41598-020-60761-5
A systematic evaluation of IgM and IgG antibody assay accuracy in diagnosing acute Zika Virus infection in Brazil; lessons relevant to emerging infections
Aetiology and Outcome of Non-Traumatic Coma in African Children: Protocol for a Systematic Review and Meta-Analysis
Neurological disease in adults with Zika and chikungunya virus infection in Northeast Brazil: a prospective observational study
Brito Ferreira, M. L., Militão de Albuquerque, M. D. F. P., de Brito, C. A. A., de Oliveira França, R. F., Porto Moreira, Á. J., de Morais Machado, M. Í., . . . Solomon, T. (2020). Neurological disease in adults with Zika and chikungunya virus infection in Northeast Brazil: a prospective observational study. The Lancet Neurology, 19(10), 826-839. doi:10.1016/s1474-4422(20)30232-5
Methods of inactivation of SARS-CoV-2 for downstream biological assays.
Patterson, E. I., Prince, T., Anderson, E. R., Casas-Sanchez, A., Smith, S. L., Cansado-Utrilla, C., . . . Hughes, G. L. (2020). Methods of inactivation of SARS-CoV-2 for downstream biological assays.. The Journal of infectious diseases. doi:10.1093/infdis/jiaa507
Neuropsychological and psychiatric outcomes in encephalitis: A multi-centre case-control study.
Harris, L., Griem, J., Gummery, A., Marsh, L., Defres, S., Bhojak, M., . . . ENCEPH UK study group. (2020). Neuropsychological and psychiatric outcomes in encephalitis: A multi-centre case-control study.. PloS one, 15(3), e0230436. doi:10.1371/journal.pone.0230436
Aetiology and outcome of non-traumatic coma in African children: protocol for a systematic review and meta-analysis
Ray, S., Fuller, C., Boubour, A., Bonnett, L., Seydel, K., & Griffiths, M. (2020). Aetiology and outcome of non-traumatic coma in African children: protocol for a systematic review and meta-analysis. doi:10.21203/rs.3.rs-17729/v1
58. Acute Bacterial Meningitis
Griffiths, M. J., Carrol, E., & Ghadasan, R. (2020). 58. Acute Bacterial Meningitis. In Hunter's Tropical Medicine and Emerging Infectious Disease. Elsevier.
Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT
Mallucci, C. L., Jenkinson, M. D., Conroy, E. J., Hartley, J. C., Brown, M., Moitt, T., . . . Gamble, C. (2020). Silver-impregnated, antibiotic-impregnated or non-impregnated ventriculoperitoneal shunts to prevent shunt infection: the BASICS three-arm RCT. Health Technology Assessment, 24(17), 1-114. doi:10.3310/hta24170
2019
BACTERIAL MENINGITIS IN MALAWIAN CHILDREN, 2000-2018
Nielsen, M., Ray, S. T. J., Kawaza, K., Denis, B., Gordon, S. B., Griffiths, M. J., . . . Tam, P. -Y. I. (2019). BACTERIAL MENINGITIS IN MALAWIAN CHILDREN, 2000-2018. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 101 (pp. 146). Retrieved from https://www.webofscience.com/
Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation
Mallucci, C. L., Jenkinson, M. D., Conroy, E. J., Hartley, J. C., Brown, M., Dalton, J., . . . Gamble, C. (2019). Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation. Lancet, 394(10208), 1530-1539. doi:10.1016/S0140-6736(19)31603-4
Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study
Solomon, T. (2019). Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study. PLoS One.
Targeted metagenomic sequencing enhances the identification of pathogens associated with acute infection
Goh, C., Golubchik, T., Ansari, M. A., de Cesare, M., Trebes, A., Elliott, I., . . . Bowden, R. (2019). Targeted metagenomic sequencing enhances the identification of pathogens associated with acute infection. doi:10.1101/716902
TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection
Amrun, S. N., Tan, J. J. L., Rickett, N. Y., Cox, J. A., Lee, B., Griffiths, M. J., . . . Ng, L. F. P. (2019). TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection. doi:10.1101/682914
P96 Screening for cerebrovascular pathology on the basis of positive family history in the paediatric population
Millward, C. P., Tonder, L. V., Foster, M., Williams, D., Griffiths, M., Kneen, R., . . . Mallucci, C. (2019). P96 Screening for cerebrovascular pathology on the basis of positive family history in the paediatric population. In Journal of Neurology, Neurosurgery & Psychiatry Vol. 90 (pp. e47.3-e47). BMJ. doi:10.1136/jnnp-2019-abn.153
HIV is associated with endothelial activation despite ART, in a sub-Saharan African setting
Kamtchum-Tatuene, J., Mwandumba, H., Al-Bayati, Z., Flatley, J., Griffiths, M., Solomon, T., & Benjamin, L. (2019). HIV is associated with endothelial activation despite ART, in a sub-Saharan African setting. Neurology Neuroimmunology & Neuroinflammation, 6(2). doi:10.1212/nxi.0000000000000531
141 Systematic cerebrospinal fluid testing improves pathogen detection among childhood central nervous system infections in Yogyakarta, Indonesia
Griffiths, M. J., Aifa, B., Prince, T., & Solomon, T. (2019). 141 Systematic cerebrospinal fluid testing improves pathogen detection among childhood central nervous system infections in Yogyakarta, Indonesia. In Developmental Medicine and Child Neurology Vol. 61 (pp. 15-112). LIverpool: Wiley-Blackwell.
150 Diverse intra‐cranial imaging abnormalities identified in Malawian children with febrile coma
Griffiths, M. J., Ray, S., & Fuller, C. (2019). 150 Diverse intra‐cranial imaging abnormalities identified in Malawian children with febrile coma. In Developmental Medicine and Child Neurology Vol. 61 (pp. 15-112). Liverpool: Wiley-Blackwell.
159 The benefit of workshops for families with children with congenital Zika syndrome in Brazil
Griffiths, M. J., Medialdea‐Carrera, R., & Beets, K. (2019). 159 The benefit of workshops for families with children with congenital Zika syndrome in Brazil. In Developmental Medicine and Child Neurology Vol. 61 (pp. 15-112). Liverpool: Wiley-Blackwell.
Oral Session 3 Thursday 24th January 2019 - Improving the diagnosis of neurosurgical CSF infections
Griffiths, M. J., Van Tonder, L., Prince, T., Solomon, T., & Mallucci, C. (2019). Oral Session 3 Thursday 24th January 2019 - Improving the diagnosis of neurosurgical CSF infections. In Developmental Medicine and Child Neurology Vol. 61 (pp. 4-15). Liverpool: Wiley-Blackwell.
Low population Japanese encephalitis virus (JEV) seroprevalence in Udayapur district, Nepal, three years after a JE vaccination programme: a case for further catch up campaigns?
Turtle, L. C. W. (2019). Low population Japanese encephalitis virus (JEV) seroprevalence in Udayapur district, Nepal, three years after a JE vaccination programme: a case for further catch up campaigns?. PLoS Neglected Tropical Diseases, 13. doi:10.1371/journal.pntd.0007269
THE ETIOLOGY, NEUROIMAGING AND NEURODEVELOPMENTAL OUTCOME OF SEVERE FEBRILE ENCEPHALOPATHY IN MALAWIAN CHILDREN
Ray, S. T. J., Fuller, C., Stockdale, E., Dwivedi, R., Chetcuti, K., Moxon, C., . . . Seydel, K. B. (2019). THE ETIOLOGY, NEUROIMAGING AND NEURODEVELOPMENTAL OUTCOME OF SEVERE FEBRILE ENCEPHALOPATHY IN MALAWIAN CHILDREN. In AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE Vol. 101 (pp. 342). Retrieved from https://www.webofscience.com/
The Transcriptional and Protein Profile From Human Infected Neuroprogenitor Cells Is Strongly Correlated to Zika Virus Microcephaly Cytokines Phenotype Evidencing a Persistent Inflammation in the CNS
Lima, M. C., Mendonça, L. R. D., Rezende, A. M., Carrera, R. M., Aníbal-Silva, C. E., Demers, M., . . . Franca, R. F. O. (2019). The Transcriptional and Protein Profile From Human Infected Neuroprogenitor Cells Is Strongly Correlated to Zika Virus Microcephaly Cytokines Phenotype Evidencing a Persistent Inflammation in the CNS. Frontiers in Immunology, 10. doi:10.3389/fimmu.2019.01928
2018
A pragmatic cluster randomised controlled trial of a tailored intervention to improve the initial management of suspected encephalitis
Backman, R., Foy, R., Diggle, P. J., Kneen, R., Easton, A., Defres, S., . . . Comm, E. N. C. E. P. H. U. K. P. S. (2018). A pragmatic cluster randomised controlled trial of a tailored intervention to improve the initial management of suspected encephalitis. PLoS One, 13(12). doi:10.1371/journal.pone.0202257
The role of SIGLEC-1 in flavivirus infections
Prince, T. A. C., Medialdea Carrera, R., Rainbow, L., Solomon, T., Blake, N., & Griffiths, M. J. (2018). The role of SIGLEC-1 in flavivirus infections. In Encephalitis Society Conference. London.
Response
Griffiths, M. J., McGill, F., & Solomon, T. (2018). Response. Clinical Medicine, 18(4), 352. doi:10.7861/clinmedicine.18-4-352
Response.
Griffiths, M. J., McGill, F., & Solomon, T. (2018). Response.. Clinical medicine (London, England), 18(4), 352. doi:10.7861/clinmedicine.18-4-352
Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study
McGill, F. J., Griffiths, M., Bonnett, L., Geretti, A., Michael, B., Beeching, N., . . . Solomon, T. (2018). Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study. Lancet Infectious Diseases, 18(9), 992-1003. doi:10.1016/S1473-3099(18)30245-7
Response
Ellul, M., Griffiths, M., Mcgill, F., & Solomon, T. (2018). Response. Clinical Medicine, 18(3), 269-270. doi:10.7861/clinmedicine.18-3-269a
DETECTION OF BACTERIAL INFECTIONS
Griffiths, M. J. (2018, April 12). PCT/GB2019/051048, DETECTION OF BACTERIAL INFECTIONS. International.
Management of acute meningitis
Griffiths, M. J., McGill, F., & Solomon, T. (2018). Management of acute meningitis. Clinical Medicine, 18(2), 164-169. doi:10.7861/clinmedicine.18-2-164
Recommendations for enterovirus diagnostics and characterisation within and beyond Europe
Harvala, H., Broberg, E., Benschop, K., Berginc, N., Ladhani, S., Susi, P., . . . Fischer, T. K. (2018). Recommendations for enterovirus diagnostics and characterisation within and beyond Europe. Journal of Clinical Virology, 101, 11-17. doi:10.1016/j.jcv.2018.01.008
Rapid Accurate Identification of Tuberculous Meningitis Among South African Children Using a Novel Clinical Decision Tool
Goenka, A., Jeena, P. M., Mlisana, K., Solomon, T., Spicer, K., Stephenson, R., . . . Griffiths, M. J. (2018). Rapid Accurate Identification of Tuberculous Meningitis Among South African Children Using a Novel Clinical Decision Tool. The Pediatric Infectious Disease Journal, 37(3), 229-234. doi:10.1097/INF.0000000000001726
The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series
Mehta, R., Soares, C. N., Medialdea-Carrera, R., Ellul, M., Texeira da Silva, M. T., Rosala-Hallas, A., . . . Solomon, T. (2018). The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series. PLoS Neglected Tropical Diseases, 12(2). doi:10.1371/journal.pntd.0006212
The inter-rater reliability and prognostic value of coma scales in Nepali children with acute encephalitis syndrome
Ray, S., Rayamajhi, A., Bonnett, L. J., Solomon, T., Kneen, R., & Griffiths, M. J. (2018). The inter-rater reliability and prognostic value of coma scales in Nepali children with acute encephalitis syndrome. Paediatrics and International Child Health, 38(1), 60-65. doi:10.1080/20469047.2017.1398503
2017
PO163 Improving the diagnosis of encephalitis through examining host proteome and gene expression
Ellul, M., Griffiths, M., Hiscox, J., & Solomon, T. (2017). PO163 Improving the diagnosis of encephalitis through examining host proteome and gene expression. In Journal of Neurology, Neurosurgery & Psychiatry Vol. 88 (pp. A55.4-A56). BMJ. doi:10.1136/jnnp-2017-abn.191
PO214 Neuropsychological sequelae of viral meningitis
Adan, G., Griffiths, M., Bonnett, L., Miller, A., Geretti, A. M., Michael, B., . . . Solomon, T. (2017). PO214 Neuropsychological sequelae of viral meningitis. In Journal of Neurology, Neurosurgery & Psychiatry Vol. 88 (pp. A68.2-A68). BMJ. doi:10.1136/jnnp-2017-abn.235
PO232 Incidence and healthcare costs of viral meningitis in adults – a multicentre prospective observational study in england
McGill, F., Griffiths, M. J., Bonnett, L., Martin, A., Geretti, A. M., Michael, B. D., . . . Solomon, T. (2017). PO232 Incidence and healthcare costs of viral meningitis in adults – a multicentre prospective observational study in england. In Journal of Neurology, Neurosurgery & Psychiatry Vol. 88 (pp. A73.2-A73). BMJ. doi:10.1136/jnnp-2017-abn.253
PO250 Study of the feasibility and accuracy of next generation sequencing, proteomics, transcriptomics and cytokine measurement for improving the diagnosis of neurosurgical cerebrospinal fluid infection
Tonder, L. V., Griffiths, M., Mallucci, C., Jenkinson, M., Kamali, I., Griffiths, M., & Solomon, T. (2017). PO250 Study of the feasibility and accuracy of next generation sequencing, proteomics, transcriptomics and cytokine measurement for improving the diagnosis of neurosurgical cerebrospinal fluid infection. In Journal of Neurology, Neurosurgery & Psychiatry Vol. 88 (pp. A78.3-A78). BMJ. doi:10.1136/jnnp-2017-abn.271
Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function
Hemingway, C., Berk, M., Anderson, S. T., Wright, V. J., Hamilton, S., Eleftherohorinou, H., . . . Levin, M. (2017). Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function. PLOS ONE, 12(11). doi:10.1371/journal.pone.0185973
Decoding the association between herpes simplex virus and antibody‐mediated encephalitis
Ellul, M. A., & Griffiths, M. J. (2017). Decoding the association between herpes simplex virus and antibody‐mediated encephalitis. Developmental Medicine & Child Neurology, 59(8), 776-777. doi:10.1111/dmcn.13471
A Feasibility Study of Quantifying Longitudinal Brain Changes in Herpes Simplex Virus (HSV) Encephalitis Using Magnetic Resonance Imaging (MRI) and Stereology
Defres, S., Keller, S. S., Das, K., Vidyasagar, R., Parkes, L. M., Burnside, G., . . . Solomon, T. (2017). A Feasibility Study of Quantifying Longitudinal Brain Changes in Herpes Simplex Virus (HSV) Encephalitis Using Magnetic Resonance Imaging (MRI) and Stereology. PLOS ONE, 12(01), 15 pages. doi:10.1371/journal.pone.0170215
Viral meningitis: current issues in diagnosis and treatment
McGill, F., Griffiths, M. J., & Solomon, T. (2017). Viral meningitis: current issues in diagnosis and treatment. Current Opinion in Infectious Diseases, 30(2), 248-256. doi:10.1097/qco.0000000000000355
2016
The Vietnam Initiative on Zoonotic Infections (VIZIONs): An interim analysis of the epidemiology and aetiology of central nervous system infections
Griffiths, M. J. (2016). The Vietnam Initiative on Zoonotic Infections (VIZIONs): An interim analysis of the epidemiology and aetiology of central nervous system infections.
A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease
Walker, L., Griffiths, M. J., McGill, F., Lewthwaite, P., Sills, G. J., Jorgensen, A., . . . Pirmohamed, M. (2016). A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease. Biomarkers, 22(7), 635-642. doi:10.1080/1354750X.2016.1265003
ENCEPHALITIS: PARENCHYMAL LEUCOCYTES IN INFECTIOUS, IMMUNE AND UNKNOWN CAUSE
Daramola, O., Rathi, N., Michael, B. D., Griffiths, M. J., Moxham, N., Benjamin, L., . . . Solomon, T. (2016). ENCEPHALITIS: PARENCHYMAL LEUCOCYTES IN INFECTIOUS, IMMUNE AND UNKNOWN CAUSE. In Journal of Neurology, Neurosurgery & Psychiatry Vol. 87 (pp. e1.31-e1). BMJ. doi:10.1136/jnnp-2016-315106.126
The Vietnam Initiative on Zoonotic Infections (VIZIONs): An interim analysis of the epidemiology and aetiology of central nervous system infections
Brindle, H. E., Choisy, M., Tran, M. P., Doorn, R. V., Nadjm, B., Christley, R., . . . Baker, S. (2016). The Vietnam Initiative on Zoonotic Infections (VIZIONs): An interim analysis of the epidemiology and aetiology of central nervous system infections. International Journal of Infectious Diseases, 53, 18-19. doi:10.1016/j.ijid.2016.11.052
Herpes simplex encephalitis is linked with selective mitochondrial damage; a post-mortem and in vitro study
Malgorzata Wnek., Lorenzo Ressel., Ricci, E., Rodriguez-Martinez, C., Villalvazo Geurrero, J. C., Ismail, Z., . . . Michael J. Griffiths. (2016). Herpes simplex encephalitis is linked with selective mitochondrial damage; a post-mortem and in vitro study. Acta Neuropathologica, 132(3), 433-451. doi:10.1007/s00401-016-1597-2
The Interleukin-1 Balance During Encephalitis Is Associated With Clinical Severity, Blood-Brain Barrier Permeability, Neuroimaging Changes, and Disease Outcome
Michael, B. D., Griffiths, M. J., Granerod, J., Brown, D., Keir, G., Wnek, G., . . . Solomon, T. (2016). The Interleukin-1 Balance During Encephalitis Is Associated With Clinical Severity, Blood-Brain Barrier Permeability, Neuroimaging Changes, and Disease Outcome. JOURNAL OF INFECTIOUS DISEASES, 213(10), 1651-1660. doi:10.1093/infdis/jiv771
Anti-N-Methyl-D-Aspartate Receptor Encephalitis In A Young Child With Histological Evidence On Brain Biopsy Of Coexistent Herpes Simplex Virus Type 1 Infection
Ellul, M. A., Griffiths, M. J., Iyer, A., Avula, S., Defres, S., Baborie, A., . . . Kneen, R. (2016). Anti-N-Methyl-D-Aspartate Receptor Encephalitis In A Young Child With Histological Evidence On Brain Biopsy Of Coexistent Herpes Simplex Virus Type 1 Infection. Pediatric Infectious Disease Journal, 35(3), 347-349. doi:10.1097/inf.0000000000001011
Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology
Michael, B. D., Griffiths, M. J., Granerod, J., Brown, D., Davies, N. W. S., Borrow, R., & Solomon, T. (2016). Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology. PLOS ONE, 11(1). doi:10.1371/journal.pone.0146288
2015
DETECTION OF BACTERIAL INFECTION
Griffiths, M. J. (2015, October 20). PCT/GB2016/053269 (Publication No. WO/2017/068347), DETECTION OF BACTERIAL INFECTION. International.
Correction: A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal
Rayamajhi, A., Nightingale, S., Bhatta, N. K., Singh, R., Ledger, E., Bista, K. P., . . . Solomon, T. (2015). Correction: A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal. PLOS ONE, 10(8), e0136008. doi:10.1371/journal.pone.0136008
A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal
Rayamajhi, A., Nightingale, S., Bhatta, N. K., Singh, R., Ledger, E., Bista, K. P., . . . Solomon, T. (2015). A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal. PLOS ONE, 10(4), e0122608. doi:10.1371/journal.pone.0122608
2014
The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol
Jenkinson, M. D., Gamble, C., Hartley, J. C., Hickey, H., Hughes, D., Blundell, M., . . . Mallucci, C. L. (2014). The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol. Trials, 15(1). doi:10.1186/1745-6215-15-4
Distinct systemic and central nervous system disease patterns in enterovirus and parechovirus infected children
Harvala, H., Griffiths, M., Solomon, T., & Simmonds, P. (2014). Distinct systemic and central nervous system disease patterns in enterovirus and parechovirus infected children. Journal of Infection, 69(1), 69-74. doi:10.1016/j.jinf.2014.02.017
Japanese encephalitis virus infection.
Japanese encephalitis virus infection (2014). In Handbook of Clinical Neurology (pp. 561-576). Elsevier. doi:10.1016/b978-0-444-53488-0.00026-2
NMDAR encephalitis with evidence of coexistant HSV infection proven on brain biopsy; Poster 049
Griffiths, M. J., Iyer, A., Solomon, T., Kneen, R., & Barborie, A. (2014). NMDAR encephalitis with evidence of coexistant HSV infection proven on brain biopsy; Poster 049. In Developmental Medicine and Child Neurology Vol. 56. Wiley-Blackwell.
2013
Post-acute serum eosinophil and neutrophil-associated cytokine/chemokine profile can distinguish between patients with neuromyelitis optica and multiple sclerosis; and identifies potential pathophysiological mechanisms – A pilot study
Michael, B. D., Elsone, L., Griffiths, M. J., Faragher, B., Borrow, R., Solomon, T., & Jacob, A. (2013). Post-acute serum eosinophil and neutrophil-associated cytokine/chemokine profile can distinguish between patients with neuromyelitis optica and multiple sclerosis; and identifies potential pathophysiological mechanisms – A pilot study. Cytokine, 64(1), 90-96. doi:10.1016/j.cyto.2013.07.019
Improving the diagnosis of central nervous system infections in adults through introduction of a simple lumbar puncture pack
Michael, B. D., Powell, G., Curtis, S., Bailey, L., Almond, S., McGill, F., . . . Solomon, T. (2013). Improving the diagnosis of central nervous system infections in adults through introduction of a simple lumbar puncture pack. Emergency Medicine Journal, 30(5), 402. doi:10.1136/emermed-2012-201248
A Panel of Serum Cytokines/Chemokines Can Distinguish between Patients with Neuromyelitis Optica and Multiple Sclerosis and Identifies Potential Pathophysiological Mechanisms and Therapeutic Targets (P02.150)
Michael, B., Elsone, L., Griffiths, M., Borrow, R., Faragher, B., Solomon, T., & Jacob, A. (2013). A Panel of Serum Cytokines/Chemokines Can Distinguish between Patients with Neuromyelitis Optica and Multiple Sclerosis and Identifies Potential Pathophysiological Mechanisms and Therapeutic Targets (P02.150). In Neurology Vol. 80. Ovid Technologies (Wolters Kluwer Health). doi:10.1212/wnl.80.7_supplement.p02.150
The Functional, Social and Economic Impact of Acute Encephalitis Syndrome in Nepal – a Longitudinal Follow-Up Study
Griffiths, M. J., Lemon, J. V., Rayamajhi, A., Poudel, P., Shrestha, P., Srivastav, V., . . . Solomon, T. (2013). The Functional, Social and Economic Impact of Acute Encephalitis Syndrome in Nepal – a Longitudinal Follow-Up Study. PLoS Neglected Tropical Diseases, 7(9), e2383. doi:10.1371/journal.pntd.0002383
2012
In Enterovirus 71 Encephalitis With Cardio-Respiratory Compromise, Elevated Interleukin 1 , Interleukin 1 Receptor Antagonist, and Granulocyte Colony-Stimulating Factor Levels Are Markers of Poor Prognosis
Griffiths, M. J., Ooi, M. H., Wong, S. C., Mohan, A., Podin, Y., Perera, D., . . . Solomon, T. (2012). In Enterovirus 71 Encephalitis With Cardio-Respiratory Compromise, Elevated Interleukin 1 , Interleukin 1 Receptor Antagonist, and Granulocyte Colony-Stimulating Factor Levels Are Markers of Poor Prognosis. Journal of Infectious Diseases, 206(6), 881-892. doi:10.1093/infdis/jis446
069 Introduction of a simple lumbar puncture pack to a busy medical admissions unit improves diagnosis of central nervous system infections
Michael, B., Powell, G., Hatch, S., Bailey, L., Almond, S., Nightingale, S., . . . Solomon, T. (2012). 069 Introduction of a simple lumbar puncture pack to a busy medical admissions unit improves diagnosis of central nervous system infections. In Journal of Neurology, Neurosurgery & Psychiatry Vol. 83 (pp. e1.15-e1). BMJ. doi:10.1136/jnnp-2011-301993.111
1636 Intravenous immunoglobulin to treat Japanese encephalitis; a randomised controlled trial in Nepalese children
Nightingale, S., Rayamajhi, A., Bhatta, N., Ledger, E., Griffiths, M., Turtle, L., . . . Solomon, T. (2012). 1636 Intravenous immunoglobulin to treat Japanese encephalitis; a randomised controlled trial in Nepalese children. In Journal of Neurology, Neurosurgery & Psychiatry Vol. 83 (pp. e1.141-e1). BMJ. doi:10.1136/jnnp-2011-301993.24
1648 Raised levels of interleukin 1β, interleukin 1 receptor antagonist and G-CSF predict fatality among encephalitis patients infected with enterovirus 71
Griffiths, M., Ooi, M. H., Wong, S. C., Mohan, A., Podin, Y., Perera, D., . . . Solomon, T. (2012). 1648 Raised levels of interleukin 1β, interleukin 1 receptor antagonist and G-CSF predict fatality among encephalitis patients infected with enterovirus 71. In Journal of Neurology, Neurosurgery & Psychiatry Vol. 83 (pp. e1.142-e1). BMJ. doi:10.1136/jnnp-2011-301993.25
Encephalitis caused by flaviviruses
Turtle, L., Griffiths, M. J., & Solomon, T. (2012). Encephalitis caused by flaviviruses. QJM, 105(3), 219-223. doi:10.1093/qjmed/hcs013
2011
Clinical and prognostic features among children with acute encephalitis syndrome in Nepal; a retrospective study
Rayamajhi, A., Ansari, I., Ledger, E., Bista, K. P., Impoinvil, D. E., Nightingale, S., . . . Griffiths, M. J. (2011). Clinical and prognostic features among children with acute encephalitis syndrome in Nepal; a retrospective study. BMC Infectious Diseases, 11(1). doi:10.1186/1471-2334-11-294
PO.06 Acute varicella zoster virus encephalitis in adults: relationship between viral load, time, clinical features and outcome
Daniel, M. B., Griffiths, M., Galbraith, S. E., Stewart, A., Buckley, C., Hopkins, M., . . . Solomon, T. (2011). PO.06 Acute varicella zoster virus encephalitis in adults: relationship between viral load, time, clinical features and outcome. In Journal of Neurology, Neurosurgery & Psychiatry Vol. 82 (pp. e4). BMJ. doi:10.1136/jnnp-2011-300645.18
Whole genome expression pathway signatures after antigen stimulation: identifying diagnostic and prognostic disease markers
Griffiths, M. J., Harrison, G. L. A., & Klenermann, P. (2011). Whole genome expression pathway signatures after antigen stimulation: identifying diagnostic and prognostic disease markers.
ACUTE VARICELLA ZOSTER VIRUS ENCEPHALITIS IN ADULTS - RELATIONSHIP BETWEEN VIRAL LOAD, TIME, CLINICAL FEATURES AND OUTCOME
Michael, B. D., Griffiths, M., Stewart, A., Buckley, C., Hopkins, M., Hart, I. J., . . . Solomon, T. (2011). ACUTE VARICELLA ZOSTER VIRUS ENCEPHALITIS IN ADULTS - RELATIONSHIP BETWEEN VIRAL LOAD, TIME, CLINICAL FEATURES AND OUTCOME. EUROPEAN JOURNAL OF NEUROLOGY, 18, 474. Retrieved from https://www.webofscience.com/
Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase.
Pathan, N., Franklin, J. L., Eleftherohorinou, H., Wright, V. J., Hemingway, C. A., Waddell, S. J., . . . Levin, M. (2011). Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase.. Critical Care Medicine, 39(7), 1692-1711.
2010
Dissecting interferon-induced transcriptional programs in human peripheral blood cells.
Waddell, S. J., Popper, S. J., Rubins, K. H., Griffiths, M. J., Brown, P. O., Levin, M., & Relman, D. A. (2010). Dissecting interferon-induced transcriptional programs in human peripheral blood cells.. Plos One, 5(3), e9753.
2009
Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes
Fry, A. E., Ghansa, A., Small, K. S., Palma, A., Auburn, S., Diakite, M., . . . Kwiatkowski, D. P. (2009). Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes. Human Molecular Genetics, 18(14), 2683-2692. doi:10.1093/hmg/ddp192
Lack of Association of Interferon Regulatory Factor 1 with Severe Malaria in Affected Child-Parental Trio Studies across Three African Populations
Mangano, V. D., Clark, T. G., Auburn, S., Campino, S., Diakite, M., Fry, A. E., . . . Rockett, K. A. (2009). Lack of Association of Interferon Regulatory Factor 1 with Severe Malaria in Affected Child-Parental Trio Studies across Three African Populations. PLoS ONE, 4(1), e4206. doi:10.1371/journal.pone.0004206
Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.
Clark, T. G., Diakite, M., Auburn, S., Campino, S., Fry, A. E., Green, A., . . . Kwiatkowski, D. P. (2009). Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.. Journal of Infectious Diseases, 199(4), 569-575.
2008
Association of the GNAS locus with severe malaria
Auburn, S., Diakite, M., Fry, A. E., Ghansah, A., Campino, S., Richardson, A., . . . Kwiatkowski, D. P. (2008). Association of the GNAS locus with severe malaria. Human Genetics, 124(5), 499-506. doi:10.1007/s00439-008-0575-8
Variation in the ICAM1 gene is not associated with severe malaria phenotypes
Fry, A. E., Auburn, S., Diakite, M., Green, A., Richardson, A., Wilson, J., . . . Kwiatkowski, D. P. (2008). Variation in the ICAM1 gene is not associated with severe malaria phenotypes. Genes & Immunity, 9(5), 462-469. doi:10.1038/gene.2008.38
Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria
Fry, A. E., Griffiths, M. J., Auburn, S., Diakite, M., Forton, J. T., Green, A., . . . Kwiatkowski, D. P. (2008). Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria. Human Molecular Genetics, 17(4), 567-576. doi:10.1093/hmg/ddm331
2007
The molecular basis of paediatric malarial disease
Griffiths, M. J., & Clarke, I. A. (2007). The molecular basis of paediatric malarial disease. In Pediatric Infectious Diseases Revisited. Springer Science & Business Media.
Patterns of Host Genome–Wide Gene Transcript Abundance in the Peripheral Blood of Patients with Acute Dengue Hemorrhagic Fever
Simmons, C. P., Popper, S., Dolocek, C., Chau, T. N. B., Griffiths, M., Dung, N. T. P., . . . Farrar, J. (2007). Patterns of Host Genome–Wide Gene Transcript Abundance in the Peripheral Blood of Patients with Acute Dengue Hemorrhagic Fever. The Journal of Infectious Diseases, 195(8), 1097-1107. doi:10.1086/512162
2005
Genomewide Analysis of the Host Response to Malaria in Kenyan Children
Griffiths, M. J., Shafi, M. J., Popper, S. J., Hemingway, C. A., Kortok, M. M., Wathen, A., . . . Kwiatkowski, D. P. (2005). Genomewide Analysis of the Host Response to Malaria in Kenyan Children. The Journal of Infectious Diseases, 191(10), 1599-1611. doi:10.1086/429297
2001
Oxidative stress and erythrocyte damage in Kenyan children with severe <i>Plasmodium falciparum</i> malaria
Griffiths, M. J., Ndungu, F., Baird, K. L., Muller, D. P. R., Marsh, K., & Newton, C. R. J. C. (2001). Oxidative stress and erythrocyte damage in Kenyan children with severe <i>Plasmodium falciparum</i> malaria. British Journal of Haematology, 113(2), 486-491. doi:10.1046/j.1365-2141.2001.02758.x