Research outputs
2024
The ERK5 pathway in BRAFV600E melanoma cells plays a role in development of acquired resistance to dabrafenib but not vemurafenib.
Mondru, A. K., Wilkinson, B., Aljasir, M. A., Alrumayh, A., Greaves, G., Emmett, M., . . . Cross, M. J. (2024). The ERK5 pathway in BRAFV600E melanoma cells plays a role in development of acquired resistance to dabrafenib but not vemurafenib.. FEBS letters. doi:10.1002/1873-3468.14960
Anticancer drugs and cardiotoxicity: the role of cardiomyocyte and non-cardiomyocyte cells.
Koukorava, C., Ahmed, K., Almaghrabi, S., Pointon, A., Haddrick, M., & Cross, M. J. (2024). Anticancer drugs and cardiotoxicity: the role of cardiomyocyte and non-cardiomyocyte cells.. Frontiers in cardiovascular medicine, 11, 1372817. doi:10.3389/fcvm.2024.1372817
2023
Umbilical cord mesenchymal stromal cell-derived extracellular vesicles lack the potency to immunomodulate human monocyte-derived macrophages in vitro
da Silva, T. B., Rendra, E., David, C. A. W., Bieback, K., Cross, M. J., Wilm, B., . . . Murray, P. (2023). Umbilical cord mesenchymal stromal cell-derived extracellular vesicles lack the potency to immunomodulate human monocyte-derived macrophages in vitro. Biomedicine & Pharmacotherapy, 167, 115624. doi:10.1016/j.biopha.2023.115624
Mesothelial Cells Exhibit Characteristics of Perivascular Cells in an In Vitro Angiogenesis Assay
Koukorava, C., Ward, K., Ahmed, K., Almaghrabi, S., Dauleh, S., Pereira, S. M., . . . Wilm, B. (2023). Mesothelial Cells Exhibit Characteristics of Perivascular Cells in an In Vitro Angiogenesis Assay. Cells, 12(20), 2436. doi:10.3390/cells12202436
Mesothelial cells exhibit characteristics of perivascular cells in an <i>in vitro</i> angiogenesis assay
Vascularisation in Deep Endometriosis: A Systematic Review with Narrative Outcomes
Powell, S. G., Sharma, P., Masterson, S., Wyatt, J., Arshad, I., Ahmed, S., . . . Hapangama, D. K. (2023). Vascularisation in Deep Endometriosis: A Systematic Review with Narrative Outcomes. CELLS, 12(9). doi:10.3390/cells12091318
VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells
Mondru, A. K., Aljasir, M. A., Alrumayh, A., Nithianandarajah, G. N., Ahmed, K., Muller, J., . . . Cross, M. J. (2023). VEGF Stimulates Activation of ERK5 in the Absence of C-Terminal Phosphorylation Preventing Nuclear Localization and Facilitating AKT Activation in Endothelial Cells. Cells, 12(6), 967. doi:10.3390/cells12060967
2022
Extracellular Vesicles from Human Umbilical Cord-Derived MSCs Affect Vessel Formation In Vitro and Promote VEGFR2-Mediated cell Survival
Muñiz-García, A., Wilm, B., Murray, P., & Cross, M. J. (2022). Extracellular Vesicles from Human Umbilical Cord-Derived MSCs Affect Vessel Formation In Vitro and Promote VEGFR2-Mediated cell Survival. Cells, 11(23), 3750. doi:10.3390/cells11233750
Inhibiting ERK5 Overcomes Breast Cancer Resistance to Anti-HER2 Therapy By Targeting the G1–S Cell-Cycle Transition
Zhang, J., Pearson, A. J., Sabherwal, N., Telfer, B. A., Ali, N., Kan, K., . . . Tournier, C. (2022). Inhibiting ERK5 Overcomes Breast Cancer Resistance to Anti-HER2 Therapy By Targeting the G1–S Cell-Cycle Transition. Cancer Research Communications, 2(3), 131-145. doi:10.1158/2767-9764.crc-21-0089
2021
Development of a multicellular human cardiac spheroid to study drug-induced cardiotoxicity.
Koukorava, C., Haddrick, M., & Cross, M. (2021). Development of a multicellular human cardiac spheroid to study drug-induced cardiotoxicity.. Poster session presented at the meeting of 71st Annual British Microcirculation and Vascular Biology Society Conference.
2019
CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program
Thaventhiran, T., Wong, W., Alghanem, A. F., Alhumeed, N., Aljasir, M. A., Ramsey, S., . . . Sathish, J. G. (2019). CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program. Monoclonal Antibodies in Immunodiagnosis & Immunotherapy, 38(2), 60-69. doi:10.1089/mab.2018.0042
2018
Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process
Dickens, D., Rädisch, S., Chiduza, G. N., Giannoudis, A., Cross, M. J., Malik, H., . . . Nies, A. T. (2018). Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process. Molecular Pharmaceutics, 15(8), 3557-3572. doi:10.1021/acs.molpharmaceut.8b00547
Innovative Organotypic In Vitro Models for Safety Assessment: Aligning with regulatory requirements and understanding models of the heart, skin and liver as paradigms
Park, B. K., & Goldring, C. (2018). Innovative Organotypic In Vitro Models for Safety Assessment: Aligning with regulatory requirements and understanding models of the heart, skin and liver as paradigms. Archives of Toxicology, 92(2), 557-569. doi:10.1007/s00204-018-2152-9
Leading-Edge Approaches for In Vitro Hepatotoxicity Evaluation
LeCluyse, E. L., Norona, L. M., Akingbasote, J. A., Howell, L. S., Woodhead, J. L., Cross, M. J., . . . Goldring, C. E. (2018). Leading-Edge Approaches for In Vitro Hepatotoxicity Evaluation. In Comprehensive Toxicology Third Edition Volume 1 15 (Vol. 2, pp. V2-V2-712). doi:10.1016/B978-0-12-801238-3.64267-8
Leading-Edge Approaches for In Vitro Hepatotoxicity Evaluation
LeCluyse, E. L., Norona, L. M., Akingbasote, J. A., Howell, L. S., Woodhead, J. L., Cross, M. J., . . . Goldring, C. E. (2018). Leading-Edge Approaches for In Vitro Hepatotoxicity Evaluation. In Comprehensive Toxicology (pp. 651-712). Elsevier. doi:10.1016/b978-0-12-801238-3.64267-8
Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells
Wilkinson, E. L., Sidaway, J. E., & Cross, M. J. (2018). Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells. JOURNAL OF CELLULAR PHYSIOLOGY, 233(01), 186-200. doi:10.1002/jcp.26064
2017
RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells
Alghanem, A. F., Wilkinson, E. L., Emmett, M. S., Aljasir, M. A., Holmes, K., Rothermel, B. A., . . . Cross, M. J. (2017). RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells. Angiogenesis, 20(3), 341-358. doi:10.1007/s10456-017-9542-0
2016
Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability
Wilkinson, E. L., Sidaway, J. E., & Cross, M. J. (2016). Cardiotoxic drugs Herceptin and doxorubicin inhibit cardiac microvascular endothelial cell barrier formation resulting in increased drug permeability. Biology open, 5(10), 1362-1370. doi:10.1242/bio.020362
Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues
Ravenscroft, S. M., Pointon, A., Williams, A. W., Cross, M. J., & Sidaway, J. E. (2016). Cardiac Non-myocyte Cells Show Enhanced Pharmacological Function Suggestive of Contractile Maturity in Stem Cell Derived Cardiomyocyte Microtissues. Toxicological Sciences, 152(1), 99-112. doi:10.1093/toxsci/kfw069
2015
Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury
Cross, M. J., Berridge, B. R., Clements, P. J. M., Cove-Smith, L., Force, T. L., Hoffmann, P., . . . Park, B. K. (2015). Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury. BRITISH JOURNAL OF PHARMACOLOGY, 172(4), 957-974. doi:10.1111/bph.12979
Analysis of VEGF-Mediated ERK5 Activity in Endothelial Cells
Nithianandarajah-Jones, G. N., & Cross, M. J. (2015). Analysis of VEGF-Mediated ERK5 Activity in Endothelial Cells. Unknown Journal, 133-142. doi:10.1007/978-1-4939-2917-7_9
Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.
Olayanju, A., Copple, I., Bryan, H. K., Edge, G. T., Sison-Young, R., Wong, M. W., . . . Park, K. (2015). Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.. Free Radical Biology & Medicine, 78, 202-212.
Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2
Olayanju, A., Copple, I. M., Bryan, H. K., Edge, G. T., Sison, R. L., Wong, M. W., . . . Park, B. K. (2015). Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity—implications for therapeutic targeting of Nrf2. Free Radical Biology and Medicine, 78, 202-212. doi:10.1016/j.freeradbiomed.2014.11.003
Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies
Heslop, J. A., Hammond, T. G., Santeramo, I., Tort Piella, A., Hopp, I., Zhou, J., . . . Park, B. K. (2015). Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-Based Therapies. Stem Cells Translational Medicine, 4(4), 389-400. doi:10.5966/sctm.2014-0110
2014
The role of ERK5 in endothelial cell function
Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Müller, J., & Cross, M. J. (2014). The role of ERK5 in endothelial cell function. Biochemical Society Transactions, 42(6), 1584-1589. doi:10.1042/bst20140276
Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist
Thaventhiran, T., Alhumeed, N., Yeang, H. X. A., Sethu, S., Downey, J. S., Alghanem, A. F., . . . Sathish, J. G. (2014). Failure to upregulate cell surface PD-1 is associated with dysregulated stimulation of T cells by TGN1412-like CD28 superagonist. MABS, 6(5), 1290-1299. doi:10.4161/mabs.29758
2013
Safety pharmacology — Current and emerging concepts
Hamdam, J., Sethu, S., Smith, T., Alfirevic, A., Alhaidari, M., Atkinson, J., . . . Goldring, C. (2013). Safety pharmacology — Current and emerging concepts. Toxicology and Applied Pharmacology, 273(2), 229-241. doi:10.1016/j.taap.2013.04.039
Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity
Pointon, A., Abi-Gerges, N., Cross, M. J., & Sidaway, J. E. (2013). Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity. Toxicological Sciences, 132(2), 317-326. doi:10.1093/toxsci/kft005
2012
ERK5: Structure, regulation and function
Nithianandarajah-Jones, G. N., Wilm, B., Goldring, C. E. P., Müller, J., & Cross, M. J. (2012). ERK5: Structure, regulation and function. Cellular Signalling, 24(11), 2187-2196. doi:10.1016/j.cellsig.2012.07.007
Human Pluripotent Stem Cells for Modeling Toxicity
Sison-Young, R. L. C., Kia, R., Heslop, J., Kelly, L., Rowe, C., Cross, M. J., . . . Goldring, C. E. P. (2012). Human Pluripotent Stem Cells for Modeling Toxicity. Advances in Pharmacology, 63, 207-256. doi:10.1016/b978-0-12-398339-8.00006-9
2011
How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?
Laverty, H. G., Benson, C., Cartwright, E. J., Cross, M. J., Garland, C., Hammond, T., . . . Valentin, J. P. (2011). How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?. British Journal of Pharmacology, 163(4), 675-693. doi:10.1111/j.1476-5381.2011.01255.x
Exogenous Recombinant Dimeric Neuropilin-1 Is Sufficient to Drive Angiogenesis
Uniewicz, K. A., Cross, M. J., & Fernig, D. G. (2011). Exogenous Recombinant Dimeric Neuropilin-1 Is Sufficient to Drive Angiogenesis. Journal of Biological Chemistry, 286(1), 12-23. doi:10.1074/jbc.m110.190801
2010
ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells
Roberts, O. L., Holmes, K., Müller, J., Cross, D. A. E., & Cross, M. J. (2010). ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells. Journal of Cell Science, 123(19), 3413. doi:10.1242/jcs.080663
ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells
Roberts, O. L., Holmes, K., Müller, J., Cross, D. A. E., & Cross, M. J. (2010). ERK5 is required for VEGF-mediated survival and tubular morphogenesis of primary human microvascular endothelial cells. Journal of Cell Science, 123(18), 3189-3200. doi:10.1242/jcs.072801
VEGF Stimulates RCAN1.4 Expression in Endothelial Cells via a Pathway Requiring Ca2+/Calcineurin and Protein Kinase C-δ
Holmes, K., Chapman, E., See, V., & Cross, M. J. (2010). VEGF Stimulates RCAN1.4 Expression in Endothelial Cells via a Pathway Requiring Ca2+/Calcineurin and Protein Kinase C-δ. PLoS ONE, 5(7), e11435. doi:10.1371/journal.pone.0011435
Detection of siRNA induced mRNA silencing by RT-qPCR: considerations for experimental design
Holmes, K., Williams, C. M., Chapman, E. A., & Cross, M. J. (2010). Detection of siRNA induced mRNA silencing by RT-qPCR: considerations for experimental design. BMC Research Notes, 3(1). doi:10.1186/1756-0500-3-53
2009
ERK5 and the regulation of endothelial cell function
Roberts, O. L., Holmes, K., Müller, J., Cross, D. A. E., & Cross, M. J. (2009). ERK5 and the regulation of endothelial cell function. Biochemical Society Transactions, 37(6), 1254-1259. doi:10.1042/bst0371254
Transcriptional profiling reveals a critical role for tyrosine phosphatase VE‐PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis
Mellberg, S., Dimberg, A., Bahram, F., Hayashi, M., Rennel, E., Ameur, A., . . . Claesson‐Welsh, L. (2009). Transcriptional profiling reveals a critical role for tyrosine phosphatase VE‐PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis. The FASEB Journal, 23(5), 1490-1502. doi:10.1096/fj.08-123810
2007
Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition
Holmes, K., Roberts, O. L., Thomas, A. M., & Cross, M. J. (2007). Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition. Cellular Signalling, 19(10), 2003-2012. doi:10.1016/j.cellsig.2007.05.013
Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer
Rennel, E., Mellberg, S., Dimberg, A., Petersson, L., Botling, J., Ameur, A., . . . Gerwins, P. (2007). Endocan is a VEGF-A and PI3K regulated gene with increased expression in human renal cancer. Experimental Cell Research, 313(7), 1285-1294. doi:10.1016/j.yexcr.2007.01.021
Vascular Endothelial Growth Factor Receptor-2: Structure, function, intracellular signaling and therapeutic inhibition
Holmes, K., Roberts, O. L., Thomas, A. M., & Cross, M. J. (2007). Vascular Endothelial Growth Factor Receptor-2: Structure, function, intracellular signaling and therapeutic inhibition. Unknown Journal, 10(19), 2003-2012.
2004
The Adaptor Protein Shb Binds to Tyrosine 1175 in Vascular Endothelial Growth Factor (VEGF) Receptor-2 and Regulates VEGF-dependent Cellular Migration
Holmqvist, K., Cross, M. J., Rolny, C., Hägerkvist, R., Rahimi, N., Matsumoto, T., . . . Welsh, M. (2004). The Adaptor Protein Shb Binds to Tyrosine 1175 in Vascular Endothelial Growth Factor (VEGF) Receptor-2 and Regulates VEGF-dependent Cellular Migration. Journal of Biological Chemistry, 279(21), 22267-22275. doi:10.1074/jbc.m312729200
2003
Regulation of endothelial cell differentiation and transformation by H-Ras
Rennel, E., Cross, M. J., Klint, P., Bai, X., Arbiser, J. L., & Gerwins, P. (2003). Regulation of endothelial cell differentiation and transformation by H-Ras. Experimental Cell Research, 291(1), 189-200. doi:10.1016/s0014-4827(03)00347-1
VEGF-receptor signal transduction
Cross, M. J., Dixelius, J., Matsumoto, T., & Claesson-Welsh, L. (2003). VEGF-receptor signal transduction. Trends in Biochemical Sciences, 28(9), 488-494. doi:10.1016/s0968-0004(03)00193-2
Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin
Lundin, L., Rönnstrand, L., Cross, M., Hellberg, C., Lindahl, U., & Claesson-Welsh, L. (2003). Differential tyrosine phosphorylation of fibroblast growth factor (FGF) receptor-1 and receptor proximal signal transduction in response to FGF-2 and heparin. Experimental Cell Research, 287(1), 190-198. doi:10.1016/s0014-4827(03)00125-3
Endostatin action and intracellular signaling: β-catenin as a potential target?
Dixelius, J., Cross, M. J., Matsumoto, T., & Claesson-Welsh, L. (2003). Endostatin action and intracellular signaling: β-catenin as a potential target?. Cancer Letters, 196(1), 1-12. doi:10.1016/s0304-3835(03)00267-2
Angiostatin and endostatin inhibit endothelial cell migration in response to FGF and VEGF without interfering with specific intracellular signal transduction pathways
Eriksson, K., Magnusson, P., Dixelius, J., Claesson-Welsh, L., & Cross, M. J. (2003). Angiostatin and endostatin inhibit endothelial cell migration in response to FGF and VEGF without interfering with specific intracellular signal transduction pathways. FEBS Letters, 536(1-3), 19-24. doi:10.1016/s0014-5793(03)00003-6
The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells
Holmqvist, K., Cross, M., Riley, D., & Welsh, M. (2003). The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells. Cellular Signalling, 15(2), 171-179. doi:10.1016/s0898-6568(02)00076-1
Endostatin action and intracellular signaling: -Catenin as a potential target?
Dixelius, J., Cross, M. J., Matsumoto, T., & Claesson-Welsh, L. (2003). Endostatin action and intracellular signaling: -Catenin as a potential target?. Unknown Journal, 1(196), 1-12.
VEGF receptor signal transduction
Cross, M. J., Dixelius, J., Matsumoto, T., & Claesson-Welsh, L. (2003). VEGF receptor signal transduction. Unknown Journal, 9(28), 488-494.
2002
The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells
Cross, M. J., Lu, L., Magnusson, P., Nyqvist, D., Holmqvist, K., Welsh, M., & Claesson-Welsh, L. (2002). The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell, 13(8), 2881-2893. doi:10.1091/mbc.e02-02-0103
Role of the Src homology 2 domain-containing protein Shb in murine brain endothelial cell proliferation and differentiation.
Lu, L., Holmqvist, K., Cross, M., & Welsh, M. (2002). Role of the Src homology 2 domain-containing protein Shb in murine brain endothelial cell proliferation and differentiation.. Molecular Cancer Research, 13(3), 141-148.
Endostatin regulates endothelial cell adhesion and cytoskeletal organization.
Dixelius, J., Cross, M., Matsumoto, T., Sasaki, T., Timpl, R., & Claesson-Welsh, L. (2002). Endostatin regulates endothelial cell adhesion and cytoskeletal organization.. Cancer Research, 62(7), 1944-1947.
Endostatin regulates endothelial cell adhesion and cytoskeletal organization
Dixelius, J., Cross, M., Matsumoto, T., Sasaki, T., Timpl, R., & Claesson-Welsh, L. (2002). Endostatin regulates endothelial cell adhesion and cytoskeletal organization. Cancer Research, 62(7), 1844-1947.
2001
FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition
Cross, M. J., & Claesson-Welsh, L. (2001). FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition. Trends in Pharmacological Sciences, 22(4), 201-207. doi:10.1016/s0165-6147(00)01676-x
2000
G Protein-Coupled Receptor-Mediated Mitogen-Activated Protein Kinase Activation through Cooperation of Gα<sub>q</sub> and Gα<sub>i</sub> Signals
Blaukat, A., Barac, A., Cross, M. J., Offermanns, S., & Dikic, I. (2000). G Protein-Coupled Receptor-Mediated Mitogen-Activated Protein Kinase Activation through Cooperation of Gα<sub>q</sub> and Gα<sub>i</sub> Signals. Molecular and Cellular Biology, 20(18), 6837-6848. doi:10.1128/mcb.20.18.6837-6848.2000
Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A2, phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells
Cross, M. J., Hodgkin, M. N., Roberts, S., Landgren, E., Wakelam, M. J. O., & Claesson-Welsh, L. (2000). Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A2, phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells. Journal of Cell Science, 113(4), 643-651. doi:10.1242/jcs.113.4.643
1997
Inhibition of phospholipid signalling and proliferation of Swiss 3T3 cells by the wortmannin analogue demethoxyviridin
Cross, M. J., Hodgkin, M. N., Plumb, J. A., Brunton, V. G., Stewart, A., MacAully, G., . . . Wakelam, M. J. O. (1997). Inhibition of phospholipid signalling and proliferation of Swiss 3T3 cells by the wortmannin analogue demethoxyviridin. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1362(1), 29-38. doi:10.1016/s0925-4439(97)00053-7
Role and regulation of phospholipase D activity in normal and cancer cells
Wakelam, M. J. O., Martin, A., Hodgkin, M. N., Brown, F., Pettitt, T. R., Cross, M. J., . . . Reynolds, J. L. (1997). Role and regulation of phospholipase D activity in normal and cancer cells. In Advances in Enzyme Regulation Vol. 37 (pp. 29-34). Elsevier BV. doi:10.1016/s0065-2571(96)00023-4
1996
Stimulation of actin stress fibre formation mediated by activation of phospholipase D
Cross, M. J., Roberts, S., Ridley, A. J., Hodgkin, M. N., Stewart, A., Welsh, L. C., & Wakelam, M. J. O. (1996). Stimulation of actin stress fibre formation mediated by activation of phospholipase D. Current Biology, 6(5), 588-597. doi:10.1016/s0960-9822(02)00545-6
1995
Wortmannin and Its Structural Analogue Demethoxyviridin Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells
Cross, M. J., Stewart, A., Hodgkin, M. N., Kerr, D. J., & Wakelam, M. J. O. (1995). Wortmannin and Its Structural Analogue Demethoxyviridin Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells. Journal of Biological Chemistry, 270(43), 25352-25355. doi:10.1074/jbc.270.43.25352
The roles of multiple pathways in regulating bombesin-stimulated phospholipase D activity in Swiss 3T3 fibroblasts
Briscoe, C. P., Martin, A., Cross, M., & Wakelam, M. J. O. (1995). The roles of multiple pathways in regulating bombesin-stimulated phospholipase D activity in Swiss 3T3 fibroblasts. Biochemical Journal, 306(1), 115-122. doi:10.1042/bj3060115
1993
Phosphatidylcholine hydrolysis: a multiple messenger generating system.
Wakelam, M. J., Pettitt, T. R., Kaur, P., Briscoe, C. P., Stewart, A., Paul, A., . . . Currie, S. (1993). Phosphatidylcholine hydrolysis: a multiple messenger generating system.. Unknown Journal, 28, 73-80.
Phosphatidylcholine hydrolysis: a source of multiple lipid messenger molecules
Wakelam, M. J. O., Briscoe, C. P., Stewart, A., Pettitt, T. R., Cross, M. J., Paul, A., . . . Hodgkin, M. (1993). Phosphatidylcholine hydrolysis: a source of multiple lipid messenger molecules. In Biochemical Society Transactions Vol. 21 (pp. 874-877). Portland Press Ltd.. doi:10.1042/bst0210874