Research
Dr. Masoud Isanejad is a researcher in clinical and precision nutrition whose work focuses on the prevention and management of sarcopenia and frailty in ageing populations, particularly among individuals with cardiometabolic multimorbidity (CMM). His research explores how nutrition, the gut microbiome, metabolic pathways, and cardiovascular health interact to influence muscle function, metabolic resilience, and healthy ageing.
Sarcopenia—defined by the progressive loss of muscle mass and strength—can occur as a natural consequence of ageing (primary sarcopenia) or be accelerated by chronic diseases such as heart failure, diabetes, and kidney disease (secondary sarcopenia). Dr. Isanejad’s research investigates the biological mechanisms linking these conditions, with particular emphasis on the diet–gut microbiome–metabolism–muscle axis.
Using metabotyping and multi-omics approaches, including metabolomics, lipidomics, and biomarker profiling from blood and other biofluids, his work identifies metabolic signatures associated with muscle decline, inflammation, and cardiometabolic risk. He is particularly interested in the role of gut microbiome–derived metabolites and their influence on host metabolic pathways and cardiovascular health.
A central goal of his research is to translate mechanistic insights into practical and scalable nutritional interventions. Through epidemiological analyses, deep phenotyping studies, and clinical trials, Dr. Isanejad aims to develop personalised nutrition strategies that can improve muscle health, reduce cardiometabolic risk, and support healthier ageing.
His work contributes to advancing precision nutrition approaches targeting the gut–muscle–heart axis to improve outcomes in ageing populations with cardiometabolic disease.
Population based studies to investigate the risk factors associated with musculoskeletal deterioration, frailty, sarcopenia and falls
Intervention to prevent and reverse frailty in older people
Implication of technological advancement to enable older people live longer and independent at home
Research grants
BIGPICTURE-HF: BoostInG and Partnership In Clinical, Translational Understanding moleculaR biology of in Heart failure and Frailty
BRITISH ACADEMY (UK)
March 2025 - March 2026
FATIMAH AHMED SALEM ALMUBARAK Bench fees
ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)
October 2025 - September 2026
ARWA ABDULLAH SUDAN ALMUTAIRI Bench fees
ROYAL EMBASSY OF SAUDI ARABIA CULTURAL BUREAU IN LONDON (UK)
August 2025 - July 2026
HDHL- Combining vitamin E-functionalized chocolate with physical exercise to reduce the risk of protein-energy malnutrition in aged people (CHOKO-AGE)
UK RESEARCH AND INNOVATION
April 2021 - April 2025
Research collaborations
Stuart Phillips
Professor
Department Of Kinesiology, McMaster University
Nutrition, Exercise, and Health Research
Professor Lyn Stefen
Associate Professor, Division of Epidemiology and Community Health
University of Miennesota
Nutritional epidemiology and the epidemiology of the cardiovascular disease. Specific research projects include studies of dietary intake and cardiovascular disease and its risk factors in adults. Recent projects include the study of dietary intake (diet patterns, added sugar, processed foods), biomarkers (metabolomics, fatty acids), adipose tissue depots, and cardiovascular disease.
Professor Francesco Galli
CHOKO-AGE
Department of Pharmaceutical Sciences, Unicersity of Perugina
Choko-age is a scientific European project that aims to tackle the age- dependent malnutrition and the metabolic decline of tissues through combining the health-promoting effects of nutrition and physical exercise
Professor Malcolm Jackson
CHOKO-AGE
Choko-age is a scientific European project that aims to tackle the age- dependent malnutrition and the metabolic decline of tissues by combining the health-promoting effects of nutrition and physical exercise https://chokoage.eu/
Professor Heikki Kröger, Dr Arja Erkkilä, Dr Joonas Sirola, Dr Toni Rikkonen
Research Team
Kuopio Musculoskeletal Research Unit, University of Eastern Finland
Kuopio Osteoporosis Risk Factor and Prevention (OSTPRE) Study - a population-based prospective cohort study- started in 1989 – was originally aimed to investigate factors associated with bone mineral density, bone loss, falls and fractures in a target population of 14 220 peri- and postmenopausal women. Later the scope was broadened and especially the 25-year follow-up enquiry in 2014 focused on physical, psychological and social factors related to healthy aging and mortality. The unique long-term design of the study allows identification of risk and protective factors for several somatic and mental health outcomes (including some non-skeletal chronic health disorders, functional capacity and subjective wellbeing). Merging the OSTPRE questionnaire data with data from National health registers enables the validation of self-reports and broadens the scope for other important health disorders. http://www.uef.fi/en/web/kmru/ostpre