Research
Research Interest 1
Cell and molecular biology of bone.
Research grants
Bone anabolic effects of low dose parathyroid hormone.
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
October 2005 - September 2006
ICAC (Integrated Clinical Arthritis Centre) Grant.
ARTHRITIS RESEARCH CAMPAIGN
April 2002 - October 2004
Investigating the mechanisms of ATP release and interconversion from osteoblasts.
ARTHRITIS RESEARCH CAMPAIGN
May 2006 - January 2010
Regulation of P2Y receptor-mediated Ca2+ transients by membrane potential in arterial smooth muscle cells.
BRITISH HEART FOUNDATION (UK)
February 2005 - January 2007
Investigation of how extracellular nucleotides synergise with growth factors to stimulate gene expression, cell proliferation and neoplastic progression
NORTH WEST CANCER RESEARCH FUND
April 1998 - December 2001
Find AKUre.
THE ALKAPTONURIA SOCIETY (UK)
May 2009 - May 2013
ATPBone—Fighting osteoporosis by blocking nucleotides: purinergic signalling in bone formation and homeostasis
EUROPEAN COMMISSION
January 2008 - December 2010
Establishment of an advanced electron microscopy unit.
WELLCOME TRUST (UK)
August 2004 - October 2009
The Pathogenesis of Tissue Damage in Alkaptonuria
THE ALKAPTONURIA SOCIETY (UK)
August 2006 - August 2007
High resolution analysis of phenotype in manipulated complex tissues.
BIOTECHNOLOGY & BIOLOGICAL SCIENCE RESEARCH COUNCIL
November 2003 - November 2004
A preclinical feasibility study using recombinant homogentisic acid dehydrogenase as an enzyme replacement therapy for Alkaptonuria
WELLCOME TRUST (UK)
June 2014 - May 2015
Nociceptive purinergic P2X receptors in equine laminae and nerves – potential molecular targets for treating laminitis
PET PLAN CHARITABLE TRUST (UK)
October 2009 - September 2010
Effects of ultrasound on ATP release from human osteoblasts in vitro.
WRIGHTINGTON, WIGAN AND LEIGH NHS FOUNDATION TRUST (UK)
March 2005 - August 2005
ATP Binding Cassette (ABC) Transporters in Bone.
MEDICAL RESEARCH COUNCIL
September 2000 - August 2003
Academic Secretary Grant.
ARTHRITIS RESEARCH CAMPAIGN
April 1999 - April 2002
Investigation of the Mechanisms of Synergy and Consequences of Co-activation of Osteoblasts by Parathyroid Hormone and Extracellular Nucleotides.
ARTHRITIS RESEARCH CAMPAIGN
December 2001 - January 2005
Alkaptonuria PhD student
THE ALKAPTONURIA SOCIETY (UK)
October 2007 - March 2011
DevelopAKUre - Clinical Development of Nitisinone for Alkaptonuria
EUROPEAN COMMISSION
November 2012 - January 2019
Investigation of isoform-specific effects of PTHrP (1-173) in human osteoblasts.
ACTION MEDICAL RESEARCH (UK)
December 1998 - December 2001
Initiating events in the pigmentation of connective tissues that is the basis of the genetic disease Alkaptonuria
CHILDWICK TRUST
January 2013 - December 2015
Advanced Study of AKU in the Hgd-/-Mouse
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
July 2014 - December 2020
Administration of B.N.A.
BRITISH NEUROSCIENCE ASSOCIATION (UK)
October 1997 - August 2011
The expression and functional significance of P2 receptor subtypes in normal and pathological bone.
ARTHRITIS RESEARCH CAMPAIGN
October 1999 - September 2004
Assessment of Ochronosis in Ear Biopsies in AKU Patients
LIVERPOOL UNIVERSITY HOSPITALS NHS FOUNDATION TRUST (UK), ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
June 2012 - October 2027
Assessment of Disease Progress in the Rare Disease Alkaptonuria by Quantitative Image Analysis
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
November 2014 - June 2020
Bench fees ID201207048
THE CULTURAL OFFICE OF THE EMBASSY OF THE STATE OF KUWAIT (UK)
October 2016 - September 2019
Pathophysiology and therapeutic studies in Alkaptonurua
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
January 2016 - December 2026
Metabolomic consequences of silencing the HGD Gene
LIVERPOOL UNIVERSITY HOSPITALS NHS FOUNDATION TRUST (UK)
December 2022 - November 2023
Metabolomic consequences of silencing the HGD gene
ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
November 2019 - November 2023
AKU Metabolomics
LIVERPOOL UNIVERSITY HOSPITALS NHS FOUNDATION TRUST (UK), ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
February 2019 - January 2021
Combatting tyrosinaemia in AKU
THE ALKAPTONURIA SOCIETY (UK)
October 2016 - September 2019
Effects of APPA on ochronosis
AKL RESEARCH & DEVELOPMENT LTD (UK)
November 2016 - January 2018
Research project investigating Protrusions, Excrescences and Adipocytes; new players in osteoarthritis
THE TERESA ROSENBAUM GOLDEN CHARITABLE TRUST (THE ROSETREES TRUST) (UK)
July 2015 - June 2018
Exploring the metabolome of the aging and degenerating musculoskeletal system in the genetic disease Alkaptonuria
AGILENT TECHNOLOGIES (USA), ROYAL LIVERPOOL AND BROADGREEN UNIVERSITY HOSPITALS NHS TRUST (UK)
September 2015 - August 2018