Research outputs
Selected research outputs
- An antibody-drug conjugate exploiting a bacterial immune evasion mechanism is effective against multidrug resistant <i>Neisseria gonorrhoeae</i> (Preprint - 2025)
- Pathogenic <i>Neisseria</i> Bind the Complement Protein CFHR5 <i>via</i> Outer Membrane Porins (Journal article - 2022)
- Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by <i>Neisseria meningitidis</i> (Journal article - 2021)
- Competition between antagonistic complement factors for a single protein on <i>N-meningitidis</i> rules disease susceptibility (Journal article - 2014)
2025
An antibody-drug conjugate exploiting a bacterial immune evasion mechanism is effective against multidrug resistant <i>Neisseria gonorrhoeae</i>
Bacteriocin-like peptides encoded by a horizontally acquired island mediate <i>Neisseria gonorrhoeae</i> autolysis
Poncin, K., Mckeand, S. A., Lavender, H., Kurzyp, K., Harrison, O. B., Roberti, A., . . . Tang, C. M. (2025). Bacteriocin-like peptides encoded by a horizontally acquired island mediate <i>Neisseria gonorrhoeae</i> autolysis. PLOS BIOLOGY, 23(2). doi:10.1371/journal.pbio.3003001
DMB labelling for detection and analysis of capsular polysaccharides
2024
Tackling immunosuppression by <i>Neisseria gonorrhoeae</i> to facilitate vaccine design
Jones, R. A., Ramirez-Bencomo, F., Whiting, G., Fang, M., Lavender, H., Kurzyp, K., . . . Tang, C. M. (2024). Tackling immunosuppression by <i>Neisseria gonorrhoeae</i> to facilitate vaccine design. PLOS PATHOGENS, 20(11). doi:10.1371/journal.ppat.1012688
2023
Meningococcal factor H-binding protein: implications for disease susceptibility, virulence, and vaccines
Yee, W. -X., Barnes, G., Lavender, H., & Tang, C. M. (2023). Meningococcal factor H-binding protein: implications for disease susceptibility, virulence, and vaccines. TRENDS IN MICROBIOLOGY, 31(8), 805-815. doi:10.1016/j.tim.2023.02.011
2022
Pathogenic <i>Neisseria</i> Bind the Complement Protein CFHR5 <i>via</i> Outer Membrane Porins
Yee, W. -X., Tang, C. M., & Lavender, H. (2022). Pathogenic <i>Neisseria</i> Bind the Complement Protein CFHR5 <i>via</i> Outer Membrane Porins. INFECTION AND IMMUNITY, 90(10). doi:10.1128/iai.00377-22
2021
Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by <i>Neisseria meningitidis</i>
Earle, S. G., Lobanovska, M. M., Lavender, H., Tang, C. F., Exley, R., Ramos-Sevillano, E., . . . Maiden, M. C. J. (2021). Genome-wide association studies reveal the role of polymorphisms affecting factor H binding protein expression in host invasion by <i>Neisseria meningitidis</i>. PLOS PATHOGENS, 17(10). doi:10.1371/journal.ppat.1009992
Factor H binding protein (fHbp)-mediated differential complement resistance of a serogroup C <i>Neisseria meningitidis</i> isolate from cerebrospinal fluid of a patient with invasive meningococcal disease.
Facchetti, A., Wheeler, J. X., Vipond, C., Whiting, G., Lavender, H., Feavers, I. M., . . . Maharjan, S. (2021). Factor H binding protein (fHbp)-mediated differential complement resistance of a serogroup C <i>Neisseria meningitidis</i> isolate from cerebrospinal fluid of a patient with invasive meningococcal disease.. Access microbiology, 3(9), 000255. doi:10.1099/acmi.0.000255
2019
Versatile Electrochemical Sensing Platform for Bacteria
Kuss, S., Couto, R. A. S., Evans, R. M., Lavender, H., Tang, C. C., & Compton, R. G. (2019). Versatile Electrochemical Sensing Platform for Bacteria. ANALYTICAL CHEMISTRY, 91(7), 4317-4322. doi:10.1021/acs.analchem.9b00326
2017
<i>Neisseria cinerea</i> Expresses a Functional Factor H Binding Protein Which Is Recognized by Immune Responses Elicited by Meningococcal Vaccines
Lavender, H., Poncin, K., & Tang, C. M. (2017). <i>Neisseria cinerea</i> Expresses a Functional Factor H Binding Protein Which Is Recognized by Immune Responses Elicited by Meningococcal Vaccines. INFECTION AND IMMUNITY, 85(10). doi:10.1128/IAI.00305-17
2016
Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by <i>Neisseria meningitidis</i>
Barnwal, R. P., Loh, E., Godin, K. S., Yip, J., Lavender, H., Tang, C. M., & Varani, G. (2016). Structure and mechanism of a molecular rheostat, an RNA thermometer that modulates immune evasion by <i>Neisseria meningitidis</i>. NUCLEIC ACIDS RESEARCH, 44(19), 9426-9437. doi:10.1093/nar/gkw584
Thermoregulation of Meningococcal fHbp, an Important Virulence Factor and Vaccine Antigen, Is Mediated by Anti-ribosomal Binding Site Sequences in the Open Reading Frame
Loh, E., Lavender, H., Tan, F., Tracy, A., & Tang, C. M. (2016). Thermoregulation of Meningococcal fHbp, an Important Virulence Factor and Vaccine Antigen, Is Mediated by Anti-ribosomal Binding Site Sequences in the Open Reading Frame. PLOS PATHOGENS, 12(8). doi:10.1371/journal.ppat.1005794
2014
Competition between antagonistic complement factors for a single protein on <i>N-meningitidis</i> rules disease susceptibility
Caesar, J. J. E., Lavender, H., Ward, P. N., Exley, R. M., Eaton, J., Chittock, E., . . . Lea, S. M. (2014). Competition between antagonistic complement factors for a single protein on <i>N-meningitidis</i> rules disease susceptibility. ELIFE, 3. doi:10.7554/eLife.04008
2013
Distinct Binding and Immunogenic Properties of the Gonococcal Homologue of Meningococcal Factor H Binding Protein
Jongerius, I., Lavender, H., Tan, L., Ruivo, N., Exley, R. M., Caesar, J. J. E., . . . Tang, C. M. (2013). Distinct Binding and Immunogenic Properties of the Gonococcal Homologue of Meningococcal Factor H Binding Protein. PLOS PATHOGENS, 9(8). doi:10.1371/journal.ppat.1003528
2012
NF-κB Regulates MICA Gene Transcription in Endothelial Cell through a Genetically Inhibitable Control Site
Lin, D., Lavender, H., Soilleux, E. J., & O'Callaghan, C. A. (2012). NF-κB Regulates MICA Gene Transcription in Endothelial Cell through a Genetically Inhibitable Control Site. JOURNAL OF BIOLOGICAL CHEMISTRY, 287(6), 4299-4310. doi:10.1074/jbc.M111.282152
Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts
Bertram, S., Heurich, A., Lavender, H., Gierer, S., Danisch, S., Perin, P., . . . Soilleux, E. J. (2012). Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts. PLOS ONE, 7(4). doi:10.1371/journal.pone.0035876
2011
Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease
Bertram, S., Glowacka, I., Mueller, M. A., Lavender, H., Gnirss, K., Nehlmeier, I., . . . Poehlmann, S. (2011). Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease. JOURNAL OF VIROLOGY, 85(24), 13363-13372. doi:10.1128/JVI.05300-11