Research outputs
2025
Investigation of anti-SARS CoV-2 multimeric bicyclic peptide inhibitors in a range of pre-clinical therapeutic settings
2024
Assessment of Favipiravir and Remdesivir in Combination for SARS-CoV-2 Infection in Syrian Golden Hamsters
Neary, M., Gallardo-Toledo, E., Sharp, J., Herriott, J., Kijak, E., Bramwell, C., . . . Owen, A. (2024). Assessment of Favipiravir and Remdesivir in Combination for SARS-CoV-2 Infection in Syrian Golden Hamsters. Viruses, 16(12). doi:10.3390/v16121838
Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case
Tatham, L., Kipar, A., Sharp, J., Kijak, E., Herriott, J., Neary, M., . . . Owen, A. (2024). Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case. MICROBIOLOGY SPECTRUM, 12(8). doi:10.1128/spectrum.03916-23
2023
Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters
Gallardo-Toledo, E., Neary, M., Sharp, J., Herriott, J., Kijak, E., Bramwell, C., . . . Owen, A. (2023). Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters. VIRUSES-BASEL, 15(11). doi:10.3390/v15112161
Evaluation of Nafamostat as Chemoprophylaxis for SARS-CoV-2 Infection in Hamsters
Neary, M., Sharp, J., Gallardo-Toledo, E., Herriott, J., Kijak, E., Bramwell, C., . . . Owen, A. (2023). Evaluation of Nafamostat as Chemoprophylaxis for SARS-CoV-2 Infection in Hamsters. VIRUSES-BASEL, 15(8). doi:10.3390/v15081744
Understanding the Degradation of Core-Shell Nanogels Using Asymmetrical Flow Field Flow Fractionation
Niezabitowska, E., Gray, D. M. M., Gallardo-Toledo, E., Owen, A., Rannard, S. P. P., & McDonald, T. O. O. (2023). Understanding the Degradation of Core-Shell Nanogels Using Asymmetrical Flow Field Flow Fractionation. JOURNAL OF FUNCTIONAL BIOMATERIALS, 14(7). doi:10.3390/jfb14070346
Ronapreve (REGN-CoV; casirivimab and imdevimab) reduces the viral burden and alters the pulmonary response to the SARS-CoV-2 Delta variant (B.1.617.2) in K18-hACE2 mice using an experimental design reflective of a treatment use case.
2022
β-Cyclodextrin-Based Nanosponges Inclusion Compounds Associated with Gold Nanorods for Potential NIR-II Drug Delivery.
Salazar Sandoval, S., Cortés-Adasme, E., Gallardo-Toledo, E., Araya, I., Celis, F., Yutronic, N., . . . Kogan, M. J. (2022). β-Cyclodextrin-Based Nanosponges Inclusion Compounds Associated with Gold Nanorods for Potential NIR-II Drug Delivery.. Pharmaceutics, 14(10), 2206. doi:10.3390/pharmaceutics14102206
2021
Transfersomes as alternative topical nanodosage forms for the treatment of skin disorders
Oyarzun, P., Gallardo-Toledo, E., Morales, J., & Arriagada, F. (2021). Transfersomes as alternative topical nanodosage forms for the treatment of skin disorders. NANOMEDICINE, 16(27), 2465-2489. doi:10.2217/nnm-2021-0335
The curvature of gold nanoparticles influences the exposure of amyloid-β and modulates its aggregation process
Tapia-Arellano, A., Gallardo-Toledo, E., Celis, F., Rivera, R., Moglia, I., Campos, M., . . . Kogan, M. J. (2021). The curvature of gold nanoparticles influences the exposure of amyloid-β and modulates its aggregation process. MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 128. doi:10.1016/j.msec.2021.112269
The Influence of Size and Chemical Composition of Silver and Gold Nanoparticles on in vivo Toxicity with Potential Applications to Central Nervous System Diseases
Baez, D. F., Gallardo-Toledo, E., Paz Oyarzun, M., Araya, E., & Kogan, M. J. (2021). The Influence of Size and Chemical Composition of Silver and Gold Nanoparticles on in vivo Toxicity with Potential Applications to Central Nervous System Diseases. INTERNATIONAL JOURNAL OF NANOMEDICINE, 16, 2187-2201. doi:10.2147/IJN.S260375
Functionalization with PEG/Angiopep-2 peptide to improve the delivery of gold nanoprisms to central nervous system: <i>in vitro</i> and <i>in vivo</i> studies
Tapia-Arellano, A., Gallardo-Toledo, E., Ortiz, C., Henriquez, J., Feijoo, C. G., Araya, E., . . . Kogan, M. J. (2021). Functionalization with PEG/Angiopep-2 peptide to improve the delivery of gold nanoprisms to central nervous system: <i>in vitro</i> and <i>in vivo</i> studies. MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 121. doi:10.1016/j.msec.2020.111785
Inorganic Nanoparticles and Their Strategies to Enhance Brain Drug Delivery
Gallardo-Toledo, E., Velasco-Aguirre, C., & Kogan, M. J. (2021). Inorganic Nanoparticles and Their Strategies to Enhance Brain Drug Delivery. In Neuromethods (pp. 149-172). Springer US. doi:10.1007/978-1-0716-0838-8_6
2020
Intranasal administration of gold nanoparticles designed to target the central nervous system: Fabrication and comparison between nanospheres and nanoprisms
Gallardo-Toledo, E., Tapia-Arellano, A., Celis, F., Sinai, T., Campos, M., Kogan, M. J., & Sintov, A. C. (2020). Intranasal administration of gold nanoparticles designed to target the central nervous system: Fabrication and comparison between nanospheres and nanoprisms. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 590. doi:10.1016/j.ijpharm.2020.119957
2018
Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core
Mendez-Rojas, C., Quiroz, G., Faundez, M., Gallardo-Garrido, C., David Pessoa-Mahana, C., Chung, H., . . . Pessoa-Mahana, H. (2018). Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core. ARCHIV DER PHARMAZIE, 351(5). doi:10.1002/ardp.201800024
2017
Improving gold nanorod delivery to the central nervous system by conjugation to the shuttle Angiopep-2
Velasco-Aguirre, C., Morales-Zavala, F., Salas-Huenuleo, E., Gallardo-Toledo, E., Andonie, O., Munoz, L., . . . Javier Kogan, M. (2017). Improving gold nanorod delivery to the central nervous system by conjugation to the shuttle Angiopep-2. NANOMEDICINE, 12(20), 2503-2517. doi:10.2217/nnm-2017-0181
2016
Metal Nanoparticles as Targeted Carriers Circumventing the Blood-Brain Barrier
Sintov, A. C., Velasco-Aguirre, C., Gallardo-Toledo, E., Araya, E., & Kogan, M. J. (2016). Metal Nanoparticles as Targeted Carriers Circumventing the Blood-Brain Barrier. In INTERNATIONAL REVIEW OF NEUROBIOLOGY, VOL 130: NANOTECHNOLOGY AND THE BRAIN (Vol. 130, pp. 199-227). doi:10.1016/bs.irn.2016.06.007
2015
Peptides and proteins used to enhance gold nanoparticle delivery to the brain: preclinical approaches
Velasco-Aguirre, C., Morales, F., Gallardo-Toledo, E., Guerrero, S., Giralt, E., Araya, E., & Kogan, M. J. (2015). Peptides and proteins used to enhance gold nanoparticle delivery to the brain: preclinical approaches. INTERNATIONAL JOURNAL OF NANOMEDICINE, 10, 4919-4936. doi:10.2147/IJN.S82310