Research outputs
Selected research outputs
- Role of Transporters and Enzymes in Metabolism and Distribution of 4-Chlorokynurenine (AV-101). (Journal article - 2024)
- Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex. (Journal article - 2021)
- Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process (Journal article - 2018)
- Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol. (Journal article - 2017)
- Chapter 5. Drug Transporters at the Blood–Brain Barrier (Chapter - 2016)
- Transport of gabapentin by LAT1 (SLC7A5) (Journal article - 2013)
- A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp (Journal article - 2013)
2025
Crossing the blood-brain barrier: emerging therapeutic strategies for neurological disease.
Pedder, J. H., Sonabend, A. M., Cearns, M. D., Michael, B. D., Zakaria, R., Heimberger, A. B., . . . Dickens, D. (2025). Crossing the blood-brain barrier: emerging therapeutic strategies for neurological disease.. The Lancet. Neurology, S1474-4422(24)00476-9. doi:10.1016/s1474-4422(24)00476-9
2024
Role of Transporters and Enzymes in Metabolism and Distribution of 4-Chlorokynurenine (AV-101).
Patel, W., Shankar, R. G., Smith, M. A., Snodgrass, H. R., Pirmohamed, M., Jorgensen, A. L., . . . Dickens, D. (2024). Role of Transporters and Enzymes in Metabolism and Distribution of 4-Chlorokynurenine (AV-101).. Molecular pharmaceutics. doi:10.1021/acs.molpharmaceut.3c00700
2023
2022
AV-101, a Pro-Drug Antagonist at the NMDA Receptor Glycine Site, Reduces L-Dopa Induced Dyskinesias in MPTP Monkeys
Bourque, M., Grégoire, L., Patel, W., Dickens, D., Snodgrass, R., & Di Paolo, T. (2022). AV-101, a Pro-Drug Antagonist at the NMDA Receptor Glycine Site, Reduces L-Dopa Induced Dyskinesias in MPTP Monkeys. Cells, 11(22), 3530. doi:10.3390/cells11223530
LAT1, a novel pharmacological target for the treatment of glioblastoma
Cappoli, N., Jenkinson, M. D., Dello Russo, C., & Dickens, D. (2022). LAT1, a novel pharmacological target for the treatment of glioblastoma. Biochemical Pharmacology, 201, 115103. doi:10.1016/j.bcp.2022.115103
2021
The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells
Ide, K., Takahashi, S., Sakai, K., Taga, Y., Ueno, T., Dickens, D., . . . Sakai, T. (2021). The dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active β1-integrin in adult tendon cells. Journal of Biological Chemistry, 100819. doi:10.1016/j.jbc.2021.100819
Inflammatory Bowel Disease: A Personalized Approach.
Konidari, A., Dickens, D., & Pirmohamed, M. (2021). Inflammatory Bowel Disease: A Personalized Approach.. Frontiers in Pediatrics, 8, 620545. doi:10.3389/fped.2020.620545
Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex.
Patel, W., Rimmer, L., Smith, M., Moss, L., Smith, M. A., Snodgrass, H. R., . . . Dickens, D. (2021). Probenecid Increases the Concentration of 7-Chlorokynurenic Acid Derived from the Prodrug 4-Chlorokynurenine within the Prefrontal Cortex. Molecular Pharmaceutics, 18(1), 113-123. doi:10.1021/acs.molpharmaceut.0c00727
2020
Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants
Gutbier, S., Kyriakou, S., Schildknecht, S., Ückert, A. -K., Brüll, M., Lewis, F., . . . Pienaar, I. S. (2020). Design and evaluation of bi-functional iron chelators for protection of dopaminergic neurons from toxicants. Archives of Toxicology, 94(9), 3105-3123. doi:10.1007/s00204-020-02826-y
2018
Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process
Dickens, D., Rädisch, S., Chiduza, G. N., Giannoudis, A., Cross, M. J., Malik, H., . . . Nies, A. T. (2018). Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process. Molecular Pharmaceutics, 15(8), 3557-3572. doi:10.1021/acs.molpharmaceut.8b00547
2017
In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line
Curley, P., Giardiello, M., Liptrott, N. J., Dickens, D., Moss, D. M., Hobson, J. J., . . . Owen, A. (2017). In vitro characterisation of solid drug nanoparticle compositions of efavirenz in a brain endothelium cell line. Journal of Interdisciplinary Nanomedicine, 2(3), 157-169. doi:10.1002/jin2.32
Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.
Dickens, D., Chiduza, G. N., Wright, G. S. A., Pirmohamed, M., Antonyuk, S. V., & Hasnain, S. S. (2017). Modulation of LAT1 (SLC7A5) transporter activity and stability by membrane cholesterol.. Scientific Reports, 7. doi:10.1038/srep43580
2016
Chapter 5. Drug Transporters at the Blood–Brain Barrier
Dickens, D., Radisch, S., & Pirmohamed, M. (n.d.). Chapter 5. Drug Transporters at the Blood–Brain Barrier. In Drug Transporters : Role and Importance in ADME and Drug Development (pp. 151-183). Royal Society of Chemistry. doi:10.1039/9781782623793-00151
2015
Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography
Sander, K., Galante, E., Gendron, T., Yiannaki, E., Patel, N., Kalber, T. L., . . . Arstad, E. (2015). Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography. JOURNAL OF MEDICINAL CHEMISTRY, 58(15), 6058-6080. doi:10.1021/acs.jmedchem.5b00652
Misoprostol-Induced Fever and Genetic Polymorphisms in Drug Transporters <i>SLCO1B1</i> and <i>ABCC4</i> in Women of Latin American and European Ancestry
Alfirevic, A., Durocher, J., Elati, A., León, W., Dickens, D., Rädisch, S., . . . Winikoff, B. (2015). Misoprostol-Induced Fever and Genetic Polymorphisms in Drug Transporters <i>SLCO1B1</i> and <i>ABCC4</i> in Women of Latin American and European Ancestry. Pharmacogenomics, 16(9), 919-928. doi:10.2217/pgs.15.53
2014
A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine
Rädisch, S., Dickens, D., Lang, T., Bonnett, L., Arlanov, R., Johnson, M. R., . . . Pirmohamed, M. (2014). A comprehensive functional and clinical analysis of ABCC2 and its impact on treatment response to carbamazepine. The Pharmacogenomics Journal, 14(5), 481-487. doi:10.1038/tpj.2014.5
2013
ABCB1 single nucleotide polymorphisms (1236C>T, 2677G>T, and 3435C>T) do not affect transport activity of human P-glycoprotein
Dickens, D., Owen, A., Alfirevic, A., & Pirmohamed, M. (2013). ABCB1 single nucleotide polymorphisms (1236C>T, 2677G>T, and 3435C>T) do not affect transport activity of human P-glycoprotein. Pharmacogenetics and Genomics, 23(6), 314-323. doi:10.1097/fpc.0b013e328360d10c
Transport of gabapentin by LAT1 (SLC7A5)
Dickens, D., Webb, S. D., Antonyuk, S., Giannoudis, A., Owen, A., Rädisch, S., . . . Pirmohamed, M. (2013). Transport of gabapentin by LAT1 (SLC7A5). Biochemical Pharmacology, 85(11), 1672-1683. doi:10.1016/j.bcp.2013.03.022
A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp
Dickens, D., Yusof, S. R., Abbott, N. J., Weksler, B., Romero, I. A., Couraud, P. -O., . . . Owen, A. (2013). A Multi-System Approach Assessing the Interaction of Anticonvulsants with P-gp. PLoS ONE, 8(5), e64854. doi:10.1371/journal.pone.0064854
2012
Lamotrigine is a substrate for OCT1 in brain endothelial cells
Dickens, D., Owen, A., Alfirevic, A., Giannoudis, A., Davies, A., Weksler, B., . . . Pirmohamed, M. (2012). Lamotrigine is a substrate for OCT1 in brain endothelial cells. Biochemical Pharmacology, 83(6), 805-814. doi:10.1016/j.bcp.2011.12.032
2011
The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein
Vogler, M., Dickens, D., Dyer, M. J. S., Owen, A., Pirmohamed, M., & Cohen, G. M. (2011). The B-cell lymphoma 2 (BCL2)-inhibitors, ABT-737 and ABT-263, are substrates for P-glycoprotein. Biochemical and Biophysical Research Communications, 408(2), 344-349. doi:10.1016/j.bbrc.2011.04.043
2009
MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins
Lam, D., Dickens, D., Reid, E. B., Loh, S. H. Y., Moisoi, N., & Martins, L. M. (2009). MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins. Proceedings of the National Academy of Sciences, 106(29), 11978-11983. doi:10.1073/pnas.0900608106