Research outputs
Selected research outputs
- Recovery from pneumonia requires efferocytosis which is impaired in smokers and those with low body mass index and enhanced by statins (Journal article - 2016)
- Household Air Pollution Causes Dose-Dependent Inflammation and Altered Phagocytosis in Human Macrophages (Journal article - 2015)
- Quantification of Efferocytosis by Single-cell Fluorescence Microscopy (Digital or visual media - 2018)
- A <i>Haemophilus</i> sp. dominates the microbiota of sputum from UK adults with non-severe community acquired pneumonia and chronic lung disease (Journal article - 2019)
- The challenge of antimicrobial prescribing for hospital-acquired pneumonia (Journal article - 2020)
- Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study (Journal article - 2021)
- Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study (Journal article - 2021)
- The utility of established prognostic scores in COVID-19 hospital admissions: a multi-centre prospective evaluation of CURB-65, NEWS2, and qSOFA (Journal article - 2020)
- Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease. (Journal article - 2024)
- HAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE® FILM ARRAY® pneumonia <i>plus</i> panel in adults with suspected non-ventilator-associated hospital-acquired pneumonia (Journal article - 2024)
2026
Top ten research priorities for community-acquired pneumonia research: UK James Lind Alliance priority setting partnership
Arnold, D., Watson, J., Ahmed, H., Wootton, D. G., & Hamilton, F. (2026). Top ten research priorities for community-acquired pneumonia research: UK James Lind Alliance priority setting partnership. The Lancet Respiratory Medicine. doi:10.1016/s2213-2600(26)00116-5
Cohort Profile: SARS-CoV-2 Immunity and Reinfection EvaluatioN (SIREN)
Foulkes, S., Munro, K., Khawam, J., Russell, S., Dunne, A., Wilson, K., . . . Hall, V. (2026). Cohort Profile: SARS-CoV-2 Immunity and Reinfection EvaluatioN (SIREN). International Journal of Epidemiology, 55(2). doi:10.1093/ije/dyag032
Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury
Stewart, I., Jacob, J., Porter, J. C., Liu, B., Tatler, A. L., Gomez, N., . . . Zongo, O. (2026). Residual lung abnormality following COVID-19 hospitalisation is characterised by biomarkers of epithelial injury. eBioMedicine, 124, 106134. doi:10.1016/j.ebiom.2026.106134
Sotrovimab versus usual care in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Abani, O., Abbas, A., Abbas, F., Abbas, K., Abbas, M., Abbasi, J., . . . Zuriaga-Alvaro, A. (2026). Sotrovimab versus usual care in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet Infectious Diseases, 26(1), 34-45. doi:10.1016/s1473-3099(25)00361-5
2025
Dynamic impact of bivalent COVID-19 vaccine boosters on systemic and mucosal antibody and T cell immunity
Kronsteiner, B., Govender, M., Liu, C., Dijokaite-Guraliuc, A., Ali, M., Hill, J., . . . Dunachie, S. J. (2025). Dynamic impact of bivalent COVID-19 vaccine boosters on systemic and mucosal antibody and T cell immunity. Scientific Reports, 15(1). doi:10.1038/s41598-025-28310-0
Are postal sputum samples a valid tool for clinical and research applications in bronchiectasis?
Jackson, L., Green, D., Wootton, D., Dunn, W., Winder, C., Senthil Kumar, D., . . . Frost, F. (2025). Are postal sputum samples a valid tool for clinical and research applications in bronchiectasis?. In Respiratory infections and bronchiectasis (pp. PA4939). European Respiratory Society. doi:10.1183/13993003.congress-2025.pa4939
Molnupiravir or nirmatrelvir–ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Abani, O., Abbas, A., Abbas, F., Abbas, J., Abbas, K., Abbas, M., . . . Zuriaga-Alvaro, A. (2025). Molnupiravir or nirmatrelvir–ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet Infectious Diseases, 25(9), 1000-1010. doi:10.1016/s1473-3099(25)00093-3
P236 Are postal sputum samples a valid clinical and research tool for use in cystic fibrosis?
Green, D., Jackson, L., Fothergill, J., Dunn, W., Shaw, V., Nazareth, D., . . . Frost, F. (2025). P236 Are postal sputum samples a valid clinical and research tool for use in cystic fibrosis?. Journal of Cystic Fibrosis, 24, S143. doi:10.1016/j.jcf.2025.03.1122
LONG-TERM INFECTION RISK IN MODERATE-SEVERE SYSTEMIC LUPUS ERYTHEMATOSUS FROM THE BRITISH ISLES LUPUS ASSESSMENT GROUP BIOLOGICS REGISTER (BILAG-BR): A PROSPECTIVE LONGITUDINAL STUDY
Achieng, S., Dyball, S., Rodziewicz, M., Sutton, E., Parker, B., Wootton, D., . . . Bruce, I. (2025). LONG-TERM INFECTION RISK IN MODERATE-SEVERE SYSTEMIC LUPUS ERYTHEMATOSUS FROM THE BRITISH ISLES LUPUS ASSESSMENT GROUP BIOLOGICS REGISTER (BILAG-BR): A PROSPECTIVE LONGITUDINAL STUDY. The Journal of Rheumatology, 52(Suppl 1), 65-66. doi:10.3899/jrheum.2025-0390.pt003
Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial
Abani, O., Abbas, A., Abbas, F., Abbas, J., Abbas, K., Abbas, M., . . . Zuriaga-Alvaro, A. (2025). Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. eClinicalMedicine, 81, 103080. doi:10.1016/j.eclinm.2025.103080
Incidence of diabetes mellitus following hospitalisation for <scp>COVID</scp> ‐19 in the United Kingdom: A prospective observational study
Tyrer, F., Gharibzadeh, S., Gillies, C., Lawson, C., Routen, A., Islam, N., . . . Khunti, K. (2025). Incidence of diabetes mellitus following hospitalisation for <scp>COVID</scp> ‐19 in the United Kingdom: A prospective observational study. Diabetes, Obesity and Metabolism, 27(2), 767-776. doi:10.1111/dom.16071
Corrigendum to “Prevalence of mental health conditions and brain fog in people with long COVID: A systematic review and meta-analysis” [General Hospital Psychiatry volume 88 (2024)10–22 10.1016/j.genhosppsych.2024.02.009]
van der Feltz-Cornelis, C. M., Turk, F., Sweetman, J., Khunti, K., Gabbay, M., Shepherd, J., . . . Banerjee, A. (2025). Corrigendum to “Prevalence of mental health conditions and brain fog in people with long COVID: A systematic review and meta-analysis” [General Hospital Psychiatry volume 88 (2024)10–22 10.1016/j.genhosppsych.2024.02.009]. General Hospital Psychiatry, 92, 112. doi:10.1016/j.genhosppsych.2024.09.006
2024
Exploring the help-seeking journeys for Long Covid from a health inequalities perspective: a qualitative study in England
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Sandercock, P., Darbyshire, J., DeMets, D., Fowler, R., Lalloo, D., Munavvar, M., . . . Landray, M. J. (2024). Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Nature Communications, 15(1). doi:10.1038/s41467-023-43644-x
P9 The presentation and outcome of community acquired pneumonia requiring hospitalisation in patients of South Asian ethnicity
Chakrabarti, B., Jenks, T., Khalid, A., Higgins, J., & Wootton, D. (2024). P9 The presentation and outcome of community acquired pneumonia requiring hospitalisation in patients of South Asian ethnicity. In ‘The CAP in the Hat’ – Pneumonia in 2024 (pp. A112.2-A113). BMJ Publishing Group Ltd and British Thoracic Society. doi:10.1136/thorax-2024-btsabstracts.170
Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
Taquet, M., Skorniewska, Z., De Deyn, T., Hampshire, A., Trender, W. R., Hellyer, P. J., . . . Turnbull, A. (2024). Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK. The Lancet Psychiatry, 11(9), 696-708. doi:10.1016/s2215-0366(24)00214-1
Low-dose azithromycin prophylaxis in patients with atrial fibrillation and chronic obstructive pulmonary disease.
Bucci, T., Wat, D., Sibley, S., Wootton, D., Green, D., Pignatelli, P., . . . Frost, F. (2024). Low-dose azithromycin prophylaxis in patients with atrial fibrillation and chronic obstructive pulmonary disease.. Internal and emergency medicine. doi:10.1007/s11739-024-03653-0
Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID.
Elneima, O., Hurst, J. R., Echevarria, C., Quint, J. K., Walker, S., Siddiqui, S., . . . Heaney, L. G. (2024). Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study - PHOSP-COVID.. ERJ open research, 10(4), 982-2023. doi:10.1183/23120541.00982-2023
HAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE® FILM ARRAY® pneumonia <i>plus</i> panel in adults with suspected non-ventilator-associated hospital-acquired pneumonia
Shafiqa, N., Aston, S., Howard, A., Turtle, L., Abrams, S., Young, B., . . . Wootton, D. G. (2024). HAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE® FILM ARRAY® pneumonia <i>plus</i> panel in adults with suspected non-ventilator-associated hospital-acquired pneumonia. BMJ Open, 14(7), e088490. doi:10.1136/bmjopen-2024-088490
1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study
Leavy, O. C., Russell, R. J., Harrison, E. M., Lone, N. I., Kerr, S., Docherty, A. B., . . . Evans, R. A. (2024). 1-year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study. ERJ Open Research, 10(5), 00474-2024. doi:10.1183/23120541.00474-2024
Histoplasma seropositivity and environmental risk factors for exposure in a general population in Upper River Region, The Gambia: A cross-sectional study
Cornell, T. R., Conteh, B., Drammeh, L., Jeffang, F., Sallah, E., Kijera, A., . . . Scantlebury, C. E. (2024). Histoplasma seropositivity and environmental risk factors for exposure in a general population in Upper River Region, The Gambia: A cross-sectional study. One Health, 18, 100717. doi:10.1016/j.onehlt.2024.100717
Risk of Cardiovascular Events after Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Patients Receiving Long-Term Low-Dose Azithromycin
Bucci, T., Wat, D., Nazareth, D., Sibley, S., Wootton, D., Lip, G. Y. H., & Frost, F. (2024). Risk of Cardiovascular Events after Acute Exacerbations of Chronic Obstructive Pulmonary Disease in Patients Receiving Long-Term Low-Dose Azithromycin. American Journal of Respiratory and Critical Care Medicine, 209(11), 1394-1396. doi:10.1164/rccm.202309-1699le
Prevalence of mental health conditions and brain fog in people with long COVID: A systematic review and meta-analysis
van der Feltz-Cornelis, C., Turk, F., Sweetman, J., Khunti, K., Gabbay, M., Shepherd, J., . . . Banerjee, A. (2024). Prevalence of mental health conditions and brain fog in people with long COVID: A systematic review and meta-analysis. General Hospital Psychiatry, 88, 10-22. doi:10.1016/j.genhosppsych.2024.02.009
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.
Liew, F., Efstathiou, C., Fontanella, S., Richardson, M., Saunders, R., Swieboda, D., . . . ISARIC investigators. (2024). Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease.. Nature immunology, 25(4), 607-621. doi:10.1038/s41590-024-01778-0
Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2024). Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 15(1). doi:10.1038/s41467-024-47320-6
Barriers to healthcare access and experiences of stigma: Findings from a coproduced Long Covid case‐finding study
Clutterbuck, D., Ramasawmy, M., Pantelic, M., Hayer, J., Begum, F., Faghy, M., . . . Alwan, N. A. (2024). Barriers to healthcare access and experiences of stigma: Findings from a coproduced Long Covid case‐finding study. Health Expectations, 27(2). doi:10.1111/hex.14037
Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group. (2024). Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial.. The Lancet. Child & adolescent health, S2352-4642(23)00316-4. doi:10.1016/s2352-4642(23)00316-4
Accelerated immune ageing is associated with COVID-19 disease severity
Lord, J. M., Veenith, T., Sullivan, J., Sharma-Oates, A., Richter, A. G., Greening, N. J., . . . Zongo, O. (2024). Accelerated immune ageing is associated with COVID-19 disease severity. Immunity & Ageing, 21(1). doi:10.1186/s12979-023-00406-z
Barriers to healthcare access: findings from a co-produced Long Covid case-finding study
Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohort
Kirwan, P. D., Hall, V. J., Foulkes, S., Otter, A. D., Munro, K., Sparkes, D., . . . Hopkins, S. (2024). Effect of second booster vaccinations and prior infection against SARS-CoV-2 in the UK SIREN healthcare worker cohort. The Lancet Regional Health - Europe, 36, 100809. doi:10.1016/j.lanepe.2023.100809
Exploring Histoplasma species seroprevalence and risk factors for seropositivity in The Gambia's working equid population: Baseline analysis of the Tackling Histoplasmosis project dataset
Cornell, T. R., Fye, B., Nyassi, E., Ceesay, F., Jallow, M., Langendonk, R. F., . . . Scantlebury, C. (2024). Exploring Histoplasma species seroprevalence and risk factors for seropositivity in The Gambia's working equid population: Baseline analysis of the Tackling Histoplasmosis project dataset. Frontiers in Veterinary Science, 11-2024. doi:10.3389/fvets.2024.1444887
Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury
Taquet, M., Skorniewska, Z., Zetterberg, H., Geddes, J. R., Mummery, C. J., Chalmers, J. D., . . . Williams, N. (2023). Post-acute COVID-19 neuropsychiatric symptoms are not associated with ongoing nervous system injury. Brain Communications, 6(1). doi:10.1093/braincomms/fcad357
Residual Lung Abnormality Following COVID-19 Hospitalisation is Characterised by Epithelial Injury
2023
Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19.
Sidhu, J. K., Siggins, M. K., Liew, F., Russell, C. D., Uruchurtu, A. S. S., Davis, C., . . . ISARIC4C investigators. (2023). Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19.. The Journal of infectious diseases, 230(1), e17-e29. doi:10.1093/infdis/jiad590
Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.
Sidhu, J. K., Siggins, M. K., Liew, F., Russell, C. D., Uruchurtu, A. S. S., Davis, C., . . . ISARIC4C investigators. (2023). Delayed mucosal anti-viral responses despite robust peripheral inflammation in fatal COVID-19.. The Journal of infectious diseases, jiad590. doi:10.1093/infdis/jiad590
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
Michael, B. D., Dunai, C., Needham, E. J., Tharmaratnam, K., Williams, R., Huang, Y., . . . Menon, D. K. (2023). Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses. Nature Communications, 14(1). doi:10.1038/s41467-023-42320-4
Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study
Elneima, O., McAuley, H. J. C., Leavy, O. C., Chalmers, J. D., Horsley, A., Ho, L. -P., . . . Williams, N. (2023). Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study. International Journal of Epidemiology, 53(1). doi:10.1093/ije/dyad165
Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease after COVID-19 hospitalisation
Clinical trials of pneumonia management assess heterogeneous outcomes and measurement instruments
Mathioudakis, A. G., Fally, M., Hansel, J., Robey, R. C., Haseeb, F., Williams, T., . . . van Wouter, G. (2023). Clinical trials of pneumonia management assess heterogeneous outcomes and measurement instruments. Journal of Clinical Epidemiology, 164, 88-95. doi:10.1016/j.jclinepi.2023.10.011
Pathways to care for Long COVID and for long‐term conditions from patients' and clinicians' perspective
Turk, F., Sweetman, J., Allsopp, G., Crooks, M., Cuthbertson, D. J., Gabbay, M., . . . van der Feltz‐Cornelis, C. (2023). Pathways to care for Long COVID and for long‐term conditions from patients' and clinicians' perspective. Journal of Evidence-Based Medicine, 16(4), 435-437. doi:10.1111/jebm.12563
One year health outcomes associated with systemic corticosteroids for COVID-19: a longitudinal cohort study
Long COVID research: an update from the PHOSP-COVID Scientific Summit
Brightling, C. E., Evans, R. A., Singapuri, A., Smith, N., Wain, L. V., Brightling, C. E., . . . Zongo, O. (2023). Long COVID research: an update from the PHOSP-COVID Scientific Summit. The Lancet Respiratory Medicine, 11(11), e93-e94. doi:10.1016/s2213-2600(23)00341-7
Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
RECOVERY Collaborative Group. (2023). Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.. The lancet. Diabetes & endocrinology, S2213-8587(23)00253-X. doi:10.1016/s2213-8587(23)00253-x
International Pediatric COVID-19 Severity Over the Course of the Pandemic
Zhu, Y., Almeida, F. J., Baillie, J. K., Bowen, A. C., Britton, P. N., Brizuela, M. E., . . . Finucane, C. (2023). International Pediatric COVID-19 Severity Over the Course of the Pandemic. JAMA Pediatrics, 177(10), 1073. doi:10.1001/jamapediatrics.2023.3117
<i>Histoplasma</i> Seropositivity in TB Patients in The Gambia: Evidence to Drive Research on a High-Priority Fungal Pathogen
Cornell, T. R., Jobe, D., Donkor, S., Wootton, D. G., Pinchbeck, G., Sutherland, J. S., & Scantlebury, C. E. (2023). <i>Histoplasma</i> Seropositivity in TB Patients in The Gambia: Evidence to Drive Research on a High-Priority Fungal Pathogen. Open Forum Infectious Diseases, 10(10). doi:10.1093/ofid/ofad510
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.
C-MORE/PHOSP-COVID Collaborative Group. (2023). Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.. The Lancet. Respiratory medicine, S2213-2600(23)00262-X. doi:10.1016/s2213-2600(23)00262-x
Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history.
Hornsby, H., Nicols, A. R., Longet, S., Liu, C., Tomic, A., Angyal, A., . . . de Silva, T. I. (2023). Omicron infection following vaccination enhances a broad spectrum of immune responses dependent on infection history.. Nature communications, 14(1), 5065. doi:10.1038/s41467-023-40592-4
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
Jackson, C., Stewart, I. D., Plekhanova, T., Cunningham, P. S., Hazel, A. L., Al-Sheklly, B., . . . Zongo, O. (2023). Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study. The Lancet Respiratory Medicine, 11(8), 673-684. doi:10.1016/s2213-2600(23)00124-8
Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis
Dawson, C., Clunie, G., Evison, F., Duncan, S., Whitney, J., Houchen-Wolloff, L., . . . Wallace, S. (2023). Prevalence of swallow, communication, voice and cognitive compromise following hospitalisation for COVID-19: the PHOSP-COVID analysis. BMJ OPEN RESPIRATORY RESEARCH, 10(1). doi:10.1136/bmjresp-2023-001647
Long Covid active case finding study protocol: A co-produced community-based pilot within the STIMULATE-ICP study (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways)
Alwan, N., Clutterbuck, D., Pantelic, M., Hayer, J., Fisher, L., Hishmeh, L., . . . STIMULATE-ICP, C. (2023). Long Covid active case finding study protocol: A co-produced community-based pilot within the STIMULATE-ICP study (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways). PLOS ONE, 18(7). doi:10.1371/journal.pone.0284297
SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease
Barnes, E., Goodyear, C. S., Willicombe, M., Gaskell, C., Siebert, S., de Silva, T. I., . . . McInnes, I. B. (2023). SARS-CoV-2-specific immune responses and clinical outcomes after COVID-19 vaccination in patients with immune-suppressive disease. NATURE MEDICINE, 29(7), 1760-+. doi:10.1038/s41591-023-02414-4
Large scale phenotyping of long COVID inflammation reveals mechanistic subtypes of disease
Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls
Zheng, B., Vivaldi, G., Daines, L., Leavy, O. C., Richardson, M., Elneima, O., . . . Zongo, O. (2023). Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls. The Lancet Regional Health - Europe, 29, 100635. doi:10.1016/j.lanepe.2023.100635
Cohort Profile: Post-hospitalisation COVID-19 study (PHOSP-COVID)
Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial
Abani, O., Abbas, A., Abbas, F., Abbas, J., Abbas, K., Abbas, M., . . . Zuriaga-Alvaro, A. (2023). Higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 401(10387), 1499-1507. doi:10.1016/s0140-6736(23)00510-x
Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study
Stewart, I., Jacob, J., George, P. M., Molyneaux, P. L., Porter, J. C., Allen, R. J., . . . Jenkins, G. R. (2023). Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study. American Journal of Respiratory and Critical Care Medicine, 207(6), 693-703. doi:10.1164/rccm.202203-0564oc
The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.
Goldswain, H., Dong, X., Penrice-Randal, R., Alruwaili, M., Shawli, G. T., Prince, T., . . . Hiscox, J. A. (2023). The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection.. Genome biology, 24(1), 47. doi:10.1186/s13059-023-02881-5
Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens
Moore, S. C., Kronsteiner, B., Longet, S., Adele, S., Deeks, A. S., Liu, C., . . . Consortium, P. (2023). Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens. Med, 4(3), 191-215.e9. doi:10.1016/j.medj.2023.02.004
Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens
Moore, S. C., Kronsteiner, B., Longet, S., Adele, S., Deeks, A. S., Liu, C., . . . Turtle, L. (2023). Evolution of long-term vaccine-induced and hybrid immunity in healthcare workers after different COVID-19 vaccine regimens. Med, 4(3), 191-215.e9. doi:10.1016/j.medj.2023.02.004
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study
McAuley, H. J. C., Evans, R. A., Bolton, C. E., Brightling, C. E., Chalmers, J. D., Docherty, A. B., . . . Zongo, O. (2023). Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study. eClinicalMedicine, 57, 101896. doi:10.1016/j.eclinm.2023.101896
Multi-organ impairment and long COVID: a 1-year prospective, longitudinal cohort study.
Dennis, A., Cuthbertson, D. J., Wootton, D., Crooks, M., Gabbay, M., Eichert, N., . . . Banerjee, A. (2023). Multi-organ impairment and long COVID: a 1-year prospective, longitudinal cohort study.. Journal of the Royal Society of Medicine, 1410768231154703. doi:10.1177/01410768231154703
Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study.
Turtle, L., Thorpe, M., Drake, T. M., Swets, M., Palmieri, C., Russell, C. D., . . . Docherty, A. B. (2023). Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study.. PLoS medicine, 20(1), e1004086. doi:10.1371/journal.pmed.1004086
Omicron BA.1/BA.2 infections in triple-vaccinated individuals enhance a diverse repertoire of mucosal and blood immune responses
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
Liew, F., Talwar, S., Cross, A., Willett, B. J., Scott, S., Logan, N., . . . Zongo, O. (2023). SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination. eBioMedicine, 87, 104402. doi:10.1016/j.ebiom.2022.104402
2022
The effects of sleep disturbance on dyspnoea and impaired lung function following COVID-19 hospitalisation: a prospective multi-centre cohort study
Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study
Plekhanova, T., Rowlands, A. V., Evans, R. A., Edwardson, C. L., Bishop, N. C., Bolton, C. E., . . . Yates, T. (2022). Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a multicentre study. International Journal of Behavioral Nutrition and Physical Activity, 19(1). doi:10.1186/s12966-022-01333-w
S112 A comparison of weekend and weekday hospital admissions due to Community Acquired Pneumonia in the North West of England: an analysis of the Advancing Quality Pneumonia program dataset
Chakrabarti, B., Wickham, S., Jenks, T., Higgins, J., Pearce, B., & Wootton, D. G. (2022). S112 A comparison of weekend and weekday hospital admissions due to Community Acquired Pneumonia in the North West of England: an analysis of the Advancing Quality Pneumonia program dataset. In ‘The Winter Soldier’ – Pneumonia epidemiology and impact (pp. A69). BMJ Publishing Group Ltd and British Thoracic Society. doi:10.1136/thorax-2022-btsabstracts.118
STIMULATE-ICP-Delphi (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways Delphi): Study protocol
van der Feltz-Cornelis, C. M., Sweetman, J., Allsopp, G., Attree, E., Crooks, M. G., Cuthbertson, D. J., . . . Banerjee, A. (2022). STIMULATE-ICP-Delphi (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways Delphi): Study protocol. PLOS ONE, 17(11), e0277936. doi:10.1371/journal.pone.0277936
Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study
Vink, E., Davis, C., MacLean, A., Pascall, D., McDonald, S. E., Gunson, R., . . . Ho, A. (2022). Viral Coinfections in Hospitalized Coronavirus Disease 2019 Patients Recruited to the International Severe Acute Respiratory and Emerging Infections Consortium WHO Clinical Characterisation Protocol UK Study. OPEN FORUM INFECTIOUS DISEASES, 9(11). doi:10.1093/ofid/ofac531
Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.
Siggins, M. K., Davies, K., Fellows, R., Thwaites, R. S., Baillie, J. K., Semple, M. G., . . . ISARIC4C Investigators. (2022). Alternative pathway dysregulation in tissues drives sustained complement activation and predicts outcome across the disease course in COVID-19.. Immunology. doi:10.1111/imm.13585
Nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
CoV-Sym: The development of a psychometrically validated patient reported outcome measure for COVID-19
Lythgoe, C., Rowe, A., Aiyegbusi, O. L., Chambers, L., Sherratt, F., Wood, J., . . . Wootton, D. (2022). CoV-Sym: The development of a psychometrically validated patient reported outcome measure for COVID-19. In 10.01 - Respiratory infections and bronchiectasis (pp. 3312). European Respiratory Society. doi:10.1183/13993003.congress-2022.3312
Long Covid active case finding: a co-produced community-based pilot within the STIMULATE-ICP study (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways)
Outcome of COVID-19 in hospitalised immunocompromised patients: an analysis of the WHO ISARIC CCP-UK prospective cohort study
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study
Evans, R. A., Leavy, O. C., Richardson, M., Elneima, O., McAuley, H. J. C., Shikotra, A., . . . Zongo, O. (2022). Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. The Lancet Respiratory Medicine, 10(8), 761-775. doi:10.1016/s2213-2600(22)00127-8
Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19
Norris, T., Razieh, C., Zaccardi, F., Yates, T., Islam, N., Gillies, C. L., . . . Khunti, K. (2022). Impact of cardiometabolic multimorbidity and ethnicity on cardiovascular/renal complications in patients with COVID-19. Heart, 108(15), 1200-1208. doi:10.1136/heartjnl-2021-320047
STIMULATE-ICP-CAREINEQUAL (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways) study protocol: Defining usual care and examining inequalities in Long Covid support
Ramasawmy, M., Mu, Y., Clutterbuck, D., Pantelic, M., Lip, G. Y. H., van der Feltz-Cornelis, C., . . . Lorgelly, P. (2022). STIMULATE-ICP-CAREINEQUAL (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways) study protocol: Defining usual care and examining inequalities in Long Covid support. PLOS ONE, 17(8), e0271978. doi:10.1371/journal.pone.0271978
Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis
Abani, O., Abbas, A., Abbas, F., Abbas, J., Abbas, K., Abbas, M., . . . Zuriaga-Alvaro, A. (2022). Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis. The Lancet, 400(10349), 359-368. doi:10.1016/s0140-6736(22)01109-6
Comparison of two T-cell assays to evaluate T-cell responses to SARS-CoV-2 following vaccination in naïve and convalescent healthcare workers
Phillips, E., Adele, S., Malone, T., Deeks, A., Stafford, L., Dobson, S. L., . . . Dunachie, S. J. (2022). Comparison of two T-cell assays to evaluate T-cell responses to SARS-CoV-2 following vaccination in naïve and convalescent healthcare workers. Clinical and Experimental Immunology, 209(1), 90-98. doi:10.1093/cei/uxac042
Evolution of long-term vaccine induced and hybrid immunity in healthcare workers after different COVID-19 vaccination regimens: a longitudinal observational cohort study
STIMULATE-ICP-CAREINEQUAL - Defining usual care and examining inequalities in Long Covid support: protocol for a mixed-methods study (part of STIMULATE-ICP: Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways)
Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission
Relph, K. A., Russell, C. D., Fairfield, C. J., Turtle, L., de Silva, T. I., Siggins, M. K., . . . Young, P. (2022). Procalcitonin Is Not a Reliable Biomarker of Bacterial Coinfection in People With Coronavirus Disease 2019 Undergoing Microbiological Investigation at the Time of Hospital Admission. Open Forum Infectious Diseases, 9(5). doi:10.1093/ofid/ofac179
STIMULATE-ICP-Delphi (Symptoms, Trajectory, Inequalities and Management: Understanding Long-COVID to Address and Transform Existing Integrated Care Pathways Delphi): Study protocol
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study
Närhi, F., Moonesinghe, S. R., Shenkin, S. D., Drake, T. M., Mulholland, R. H., Donegan, C., . . . Young, P. (2022). Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study. The Lancet Digital Health, 4(4), e220-e234. doi:10.1016/s2589-7500(22)00018-8
Multi-organ impairment and Long COVID: a 1-year prospective, longitudinal cohort study
Interstitial lung damage following COVID-19 hospitalisation: an interim analysis of the UKILD Post-COVID study
Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Abani, O., Abbas, A., Abbas, F., Abbas, M., Abbasi, S., Abbass, H., . . . Zyengi, S. (2022). Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 399(10325), 665-676. doi:10.1016/s0140-6736(22)00163-5
Comparison of two T cell assays to evaluate T cell responses to SARS-CoV-2 following vaccination in naïve and convalescent healthcare workers
Device-assessed sleep and physical activity in individuals recovering from a hospital admission for COVID-19: a prospective, multicentre study
SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.
Dejnirattisai, W., Huo, J., Zhou, D., Zahradník, J., Supasa, P., Liu, C., . . . Screaton, G. R. (2022). SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses.. Cell, 185(3), 467-484.e15. doi:10.1016/j.cell.2021.12.046
Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Abani, O., Abbas, A., Abbas, F., Abbas, M., Abbasi, S., Abbass, H., . . . Zuriaga-Alvaro, A. (2022). Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 399(10320), 143-151. doi:10.1016/s0140-6736(21)01825-0
T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study
Angyal, A., Longet, S., Moore, S. C., Payne, R. P., Harding, A., Tipton, T., . . . Chalk, J. (2022). T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study. The Lancet Microbe, 3(1), e21-e31. doi:10.1016/s2666-5247(21)00275-5
2021
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
de Silva, T. I., Liu, G., Lindsey, B. B., Dong, D., Moore, S. C., Hsu, N. S., . . . Dong, T. (2021). The impact of viral mutations on recognition by SARS-CoV-2 specific T cells. iScience, 24(11), 103353. doi:10.1016/j.isci.2021.103353
Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine
Payne, R. P., Longet, S., Austin, J. A., Skelly, D. T., Dejnirattisai, W., Adele, S., . . . Zawia, A. A. T. (2021). Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine. Cell, 184(23), 5699-5714.e11. doi:10.1016/j.cell.2021.10.011
Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study
Evans, R. A., McAuley, H. J. C., Harrison, E. M., Shikotra, A., Singapuri, A., Sereno, M., . . . Zongo, O. (2021). Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study. The Lancet Respiratory Medicine, 9(11), 1275-1287. doi:10.1016/s2213-2600(21)00383-0
A prenylated dsRNA sensor protects against severe COVID-19
Wickenhagen, A., Sugrue, E., Lytras, S., Kuchi, S., Noerenberg, M., Turnbull, M. L., . . . Wilson, S. J. (2021). A prenylated dsRNA sensor protects against severe COVID-19. Science, 374(6567). doi:10.1126/science.abj3624
Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study
Hurst, E. A., Mellanby, R. J., Handel, I., Griffith, D. M., Rossi, A. G., Walsh, T. S., . . . Russell, C. D. (2021). Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors: a cross-sectional study. BMJ Open, 11(10), e055435. doi:10.1136/bmjopen-2021-055435
Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID)
Wild, J. M., Porter, J. C., Molyneaux, P. L., George, P. M., Stewart, I., Allen, R. J., . . . Jenkins, R. G. (2021). Understanding the burden of interstitial lung disease post-COVID-19: the UK Interstitial Lung Disease-Long COVID Study (UKILD-Long COVID). BMJ Open Respiratory Research, 8(1), e001049. doi:10.1136/bmjresp-2021-001049
Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study
Russell, C. D., Fairfield, C. J., Drake, T. M., Turtle, L., Seaton, R. A., Wootton, D. G., . . . Young, P. (2021). Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study. The Lancet Microbe, 2(8), e354-e365. doi:10.1016/s2666-5247(21)00090-2
Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study
Drake, T. M., Riad, A. M., Fairfield, C. J., Egan, C., Knight, S. R., Pius, R., . . . Young, P. (2021). Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study. The Lancet, 398(10296), 223-237. doi:10.1016/s0140-6736(21)00799-6
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
Horby, P. W., Landray, M. J., & Grp, R. E. C. O. V. E. R. Y. C. (2021). Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. LANCET, 397(10289), 2049-2059. doi:10.1016/S0140-6736(21)00897-7
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Abani, O., Abbas, A., Abbas, F., Abbas, M., Abbasi, S., Abbass, H., . . . Zuriaga-Alvaro, A. (2021). Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 397(10285), 1637-1645. doi:10.1016/s0140-6736(21)00676-0
Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study
Dennis, A., Wamil, M., Alberts, J., Oben, J., Cuthbertson, D. J., Wootton, D., . . . Investigators, C. O. V. E. R. S. C. A. N. S. (2021). Multiorgan impairment in low-risk individuals with post-COVID-19 syndrome: a prospective, community-based study. BMJ Open, 11(3). doi:10.1136/bmjopen-2020-048391
A rapid assessment of wastewater for genomic surveillance of SARS-CoV-2 variants at sewershed scale in Louisville, KY
Dexamethasone in Hospitalized Patients with Covid-19
Wootton, D., & The RECOVERY Collaborative Group. (2021). Dexamethasone in Hospitalized Patients with Covid-19. New England Journal of Medicine, 384(8), 693-704. doi:10.1056/nejmoa2021436
Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Abaleke, E., Abbas, M., Abbasi, S., Abbott, A., Abdelaziz, A., Abdelbadiee, S., . . . Zuriaga-Alvaro, A. (2021). Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 397(10274), 605-612. doi:10.1016/s0140-6736(21)00149-5
S101 Predictors of and time frame for readmission following hospitalisation with community acquired pneumonia
Chakrabarti, B., Lane, S., Jenks, T., Higgins, J., Kanwar, E., Allen, M., & Wootton, D. G. (2021). S101 Predictors of and time frame for readmission following hospitalisation with community acquired pneumonia. In Baby and bathwater: not all lung infections are COVID-19 (pp. A61-A62). BMJ Publishing Group Ltd and British Thoracic Society. doi:10.1136/thorax-2020-btsabstracts.106
S95 The utility of established prognostic scores in COVID-19 hospital admissions: a collaborative trainee-led, multi-centre prospective evaluation of CURB-65, NEWS2, and qSOFA
Frost, F., Bradley, P., Tharmaratnam, K., Collaborators, N. W. C. O. R. R., & Wootton, D. (2021). S95 The utility of established prognostic scores in COVID-19 hospital admissions: a collaborative trainee-led, multi-centre prospective evaluation of CURB-65, NEWS2, and qSOFA. In Prognostic tools to treatments in COVID-19 (pp. A57.2-A58). BMJ Publishing Group Ltd and British Thoracic Society. doi:10.1136/thorax-2020-btsabstracts.100
2020
The utility of established prognostic scores in COVID-19 hospital admissions: a multi-centre prospective evaluation of CURB-65, NEWS2, and qSOFA
Bradley, P., Frost, F., Tharmaratnam, K., & Wootton, D. G. (2020). The utility of established prognostic scores in COVID-19 hospital admissions: a multi-centre prospective evaluation of CURB-65, NEWS2, and qSOFA. BMJ Open Respiratory Research, 7(1). doi:10.1101/2020.07.15.20154815
Utility of established prognostic scores in COVID-19 hospital admissions: multicentre prospective evaluation of CURB-65, NEWS2 and qSOFA
Bradley, P., Frost, F., Tharmaratnam, K., & Wootton, D. G. (2020). Utility of established prognostic scores in COVID-19 hospital admissions: multicentre prospective evaluation of CURB-65, NEWS2 and qSOFA. BMJ Open Respiratory Research, 7(1), e000729. doi:10.1136/bmjresp-2020-000729
Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19
Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19 (2020). New England Journal of Medicine, 383(21), 2030-2040. doi:10.1056/nejmoa2022926
The challenge of antimicrobial prescribing for hospital-acquired pneumonia
Wootton, D., Aston, S., & Felton, T. (2020). The challenge of antimicrobial prescribing for hospital-acquired pneumonia. Journal of Hospital Infection, 104(2), 198-199. doi:10.1016/j.jhin.2019.11.002
Antimicrobial prescribing for hospital-acquired pneumonia
Felton, T., & Wootton, D. (2020). Antimicrobial prescribing for hospital-acquired pneumonia. British Journal of Hospital Medicine, 81(1), 1-3. doi:10.12968/hmed.2019.0325
2019
A <i>Haemophilus</i> sp. dominates the microbiota of sputum from UK adults with non-severe community acquired pneumonia and chronic lung disease
Wootton, D. G., Cox, M. J., Gloor, G. B., Litt, D., Hoschler, K., German, E., . . . Gordon, S. B. (2019). A Haemophilus sp. dominates the microbiota of sputum from UK adults with non-severe community acquired pneumonia and chronic lung disease. Scientific Reports, 9(1). doi:10.1038/s41598-018-38090-5
S107 Predictors of 30 day readmission following hospitalization with community acquired pneumonia
Chakrabarti, B., Jenks, T., Lane, S., Higgins, J., Kanwar, E., & Wootton, D. G. (2019). S107 Predictors of 30 day readmission following hospitalization with community acquired pneumonia. In Improving outcomes in community acquired pneumonia (pp. A68.1-A68). BMJ Publishing Group Ltd and British Thoracic Society. doi:10.1136/thorax-2019-btsabstracts2019.113
Community-acquired pneumonia due to drug-resistant Enterobacteriaceae: A global perspective
Aston, S. J., & Wootton, D. G. (2019). Community-acquired pneumonia due to drug-resistant Enterobacteriaceae: A global perspective. Respirology. doi:10.1111/resp.13720
2018
Quantification of Efferocytosis by Single-cell Fluorescence Microscopy
Taruc, K., Yin, C., Wootton, D. G., & Heit, B. (n.d.). Quantification of Efferocytosis by Single-cell Fluorescence Microscopy. doi:10.3791/58149
Quantification of Efferocytosis by Single-cell Fluorescence Microscopy
Taruc, K., Yin, C., Wootton, D. G., & Heit, B. (2018). Quantification of Efferocytosis by Single-cell Fluorescence Microscopy. Journal of Visualized Experiments, (138). doi:10.3791/58149-v
The association between pre-hospital antibiotic therapy and subsequent in-hospital mortality in adults presenting with community-acquired pneumonia: an observational study
Chakrabarti, B., Wootton, D. G., Lane, S., Kanwar, E., Somers, J., Proctor, J., . . . Woodhead, M. (2018). The association between pre-hospital antibiotic therapy and subsequent in-hospital mortality in adults presenting with community-acquired pneumonia: an observational study. Pneumonia, 10. doi:10.1186/s41479-018-0047-4
2017
A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days
Wootton, D. G., Dickinson, L., Pertinez, H., Court, J., Eneje, O., Keogan, L., . . . Diggle, P. J. (2017). A longitudinal modelling study estimates acute symptoms of community acquired pneumonia recover to baseline by 10 days. European Respiratory Journal, 49(6). doi:10.1183/13993003.02170-2016
A Sputum Volatile Organic Compound Pattern Associated With Bacteraemic Pneumococcal Community Acquired Pneumonia
Wootton, D., Airey, G., Keogan, L., Eneje, O., Court, J., Macfarlane, L., . . . Probert, C. (2017). A Sputum Volatile Organic Compound Pattern Associated With Bacteraemic Pneumococcal Community Acquired Pneumonia. In American Journal of Respiratory and Critical Care Medicine Vol. 195 (pp. a7627). doi:10.1164/ajrccm-conference.2017.195.1_meetingabstracts.a7627
2016
Recovery from pneumonia requires efferocytosis which is impaired in smokers and those with low body mass index and enhanced by statins
Wootton, D. G., Diggle, P. J., Court, J., Eneje, O., Keogan, L., Macfarlane, L., . . . Gordon, S. B. (2016). Recovery from pneumonia requires efferocytosis which is impaired in smokers and those with low body mass index and enhanced by statins. Thorax, 71(11), 1052-1054. doi:10.1136/thoraxjnl-2016-208505
Correction
Correction (2016). doi:10.1136/thoraxjnl-2015-207770.350corr1
Modelling Symptomatic Recovery from Community Acquired Pneumonia Reveals the Association of Age and Smoking with Extent of Recovery
Wootton, D., Keogan, L., Gordon, S., Eneje, O., Court, J., Macfarlane, L., . . . Diggle, P. (2016). Modelling Symptomatic Recovery from Community Acquired Pneumonia Reveals the Association of Age and Smoking with Extent of Recovery. In American Journal of Respiratory and Critical Care Medicine Vol. 193 (pp. a2123). doi:10.1164/ajrccm-conference.2016.193.1_meetingabstracts.a2123
2015
The Genus Haemophilus Was Dominant in a Cohort with Community Acquired Pneumonia and Low Species Diversity Was Related to Age and Prior Pulmonary Disease
Wootton, D. G., Cox, M. J., Hickey, G. L., Eneje, O., Court, J., Macfarlane, L., . . . Gordon, S. B. (2015). The Genus Haemophilus Was Dominant in a Cohort with Community Acquired Pneumonia and Low Species Diversity Was Related to Age and Prior Pulmonary Disease. In American Journal of Respiratory and Critical Care Medicine Vol. 191 (pp. a3954). doi:10.1164/ajrccm-conference.2015.191.1_meetingabstracts.a3954
Household Air Pollution Causes Dose-Dependent Inflammation and Altered Phagocytosis in Human Macrophages
Rylance, J., Fullerton, D. G., Scriven, J., Aljurayyan, A. N., Mzinza, D., Barrett, S., . . . Gordon, S. B. (2015). Household Air Pollution Causes Dose-Dependent Inflammation and Altered Phagocytosis in Human Macrophages. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 52(5), 584-593. doi:10.1165/rcmb.2014-0188OC
Blinded randomised controlled trial of low-dose Adjuvant Steroids in Adults admitted to hospital with Pandemic influenza (ASAP): a trial ‘in hibernation’, ready for rapid activation
Lim, W. S., Brittain, C., Duley, L., Edwards, S., Gordon, S., Montgomery, A., . . . Wootton, D. (2015). Blinded randomised controlled trial of low-dose Adjuvant Steroids in Adults admitted to hospital with Pandemic influenza (ASAP): a trial ‘in hibernation’, ready for rapid activation. Health Technology Assessment, 19(16), 1-78. doi:10.3310/hta19160
2014
Bronchoalveolar Lavage (BAL) for Research; Obtaining Adequate Sample Yield
Collins, A. M., Rylance, J., Wootton, D. G., Wright, A. D., Wright, A. K. A., Fullerton, D. G., & Gordon, S. B. (2014). Bronchoalveolar Lavage (BAL) for Research; Obtaining Adequate Sample Yield. Journal of Visualized Experiments, (85). doi:10.3791/4345
Feasibility study for early supported discharge in adults with respiratory infection in the UK
Collins, A. M., Eneje, O. J., Hancock, C. A., Wootton, D. G., & Gordon, S. B. (2014). Feasibility study for early supported discharge in adults with respiratory infection in the UK. BMC Pulmonary Medicine, 14(1). doi:10.1186/1471-2466-14-25
The diagnosis of pneumonia requires a chest radiograph (x-ray)–yes, no or sometimes?
Wootton, D., & Feldman, C. (2014). The diagnosis of pneumonia requires a chest radiograph (x-ray)–yes, no or sometimes?. Pneumonia, 5(S1), 1-7. doi:10.15172/pneu.2014.5/464
The pathophysiology of pneumococcal pneumonia
Wootton, D. G., Aston, S. J., & Gordon, S. B. (2014). The pathophysiology of pneumococcal pneumonia. In Community-Acquired Pneumonia. European Respiratory Society. doi:10.1183/1025448x.10003313
2013
Open-Label Comparative Clinical Study of Chlorproguanil−Dapsone Fixed Dose Combination (Lapdap™) Alone or with Three Different Doses of Artesunate for Uncomplicated Plasmodium falciparum Malaria
Wootton, D. G., Opara, H., Biagini, G. A., Kanjala, M. K., Duparc, S., Kirby, P. L., . . . Winstanley, P. A. (2008). Open-Label Comparative Clinical Study of Chlorproguanil−Dapsone Fixed Dose Combination (Lapdap™) Alone or with Three Different Doses of Artesunate for Uncomplicated Plasmodium falciparum Malaria. PLoS ONE, 3(3), e1779. doi:10.1371/journal.pone.0001779
2012
Pneumococcal Specific Lung T Cells Produce Interleukin-17 That Can Increase Uptake Of Pneumococci By Human Alveolar Macrophages
Wright, A., Bangert, M., Ferreira, D. M., Collins, A., Wootton, D. G., Wright, A. D., & Gordon, S. B. (2012). Pneumococcal Specific Lung T Cells Produce Interleukin-17 That Can Increase Uptake Of Pneumococci By Human Alveolar Macrophages. In A21. FIRST RESPONDERS: MUCOSAL INNATE IMMUNITY (pp. A1076). American Thoracic Society. doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1076
Supported home-care schemes: the key to increasing outpatient care?
Collins, A. M., Wilks, S., Wootton, D., & Gordon, S. B. (2012). Supported home-care schemes: the key to increasing outpatient care?. European Respiratory Journal, 39(2), 508. doi:10.1183/09031936.00165911
Using the BTS CAP audit to evaluate local data
Singh, B., Wootton, D. G., Brown, J., Chakrabarti, B., Cooke, R. P. D., & Gordon, S. B. (2012). Using the BTS CAP audit to evaluate local data. Thorax, 67(9), 832.1-832. doi:10.1136/thoraxjnl-2011-200876
2011
P251 Junior doctors' interpretation of CXRs is more consistent than consultants in the context of possible pneumonia
Singh, B., Curtis, J., Gordon, S. B., Diggle, P. J., & Wootton, D. G. (2011). P251 Junior doctors' interpretation of CXRs is more consistent than consultants in the context of possible pneumonia. doi:10.1136/thoraxjnl-2011-201054c.251
S65 Early supported discharge scheme (ESDS) for pneumonia & lower respiratory tract infection (LRTI): are there enough suitable patients?
Collins, A., Wilks, S., Wootton, D., Wright, A., Davies, L., Hadcroft, J., & Gordon, S. (2011). S65 Early supported discharge scheme (ESDS) for pneumonia & lower respiratory tract infection (LRTI): are there enough suitable patients?. Thorax, 66(Suppl 4), A32. doi:10.1136/thoraxjnl-2011-201054b.65
2009
Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria
Miller, A. K., Bandyopadhyay, N., Wootton, D. G., Duparc, S., Kirby, P. L., Winstanley, P. A., & Ward, S. A. (2009). Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria. European Journal of Clinical Pharmacology, 65(10), 977-987. doi:10.1007/s00228-009-0672-1
Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi
Bell, D. J., Wootton, D., Mukaka, M., Montgomery, J., Kayange, N., Chimpeni, P., . . . Lalloo, D. G. (2009). Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. Malaria Journal, 8(1). doi:10.1186/1475-2875-8-204
2007
Austrian's syndrome: The first described case of pneumococcal meningitis pneumonia and endocarditis in an injecting drug user
Beadsworth, M. B. J., Wooton, D., Chenzbraun, A., & Beeching, N. J. (2007). Austrian's syndrome: The first described case of pneumococcal meningitis pneumonia and endocarditis in an injecting drug user. European Journal of Internal Medicine, 18(8), 605-606. doi:10.1016/j.ejim.2007.03.012
2006
Malaria: clinical features and recommended management
Wootton, D., Beeching, N., & Lalloo, D. (2006). Malaria: clinical features and recommended management. Prescriber, 17(21), 44-52. doi:10.1002/psb.437
Undated
Recovery from community acquired pneumonia
Wootton, D. (n.d.). Recovery from community acquired pneumonia. (PhD Thesis, University of Liverpool).
Sustained T Cell Immunity, Protection and Boosting Using Extended Dosing Intervals of BNT162b2 mRNA Vaccine
Payne, R. P., Longet, S., Austin, J. A., Skelly, D., Dejnirattisai, W., Adele, S., . . . Consortium, T. P. I. T. C. H. (n.d.). Sustained T Cell Immunity, Protection and Boosting Using Extended Dosing Intervals of BNT162b2 mRNA Vaccine.