Research outputs
2025
Topical Formulation of Repurposed FDA-Approved Compounds Inhibits Pseudomonas aeruginosa ExoU and Improves Corneal Infection Outcomes
Antimicrobial concentrations in the cornea and aqueous humour: a meta-analysis.
McLean, K., Dawson, G., Foulkes, D., Herbert, R., Popova, P., Bernard-Deshong, D., . . . Kaye, S. B. (2025). Antimicrobial concentrations in the cornea and aqueous humour: a meta-analysis.. The British journal of ophthalmology, bjo-2025-327962. doi:10.1136/bjo-2025-327962
Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence.
Nolan, A., Foulkes, D. M., Fairweather, E. E., Alarcon, M. F., Linford, C., Sellin, A., . . . Wright, H. (2025). Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence.. Rheumatology (Oxford, England), keaf437. doi:10.1093/rheumatology/keaf437
Regulation of bacterial phosphorelay systems.
Foulkes, D. M., Cooper, D. M., Westland, C., & Byrne, D. P. (2025). Regulation of bacterial phosphorelay systems.. RSC chemical biology, 6(8), 1252-1269. doi:10.1039/d5cb00016e
Autophagy inhibitors block pathogenic NET release in immune-mediated inflammatory disease without impairing host defence
Antimicrobial concentrations in the cornea and aqueous humour: a meta-analysis
Stable topical application of antimicrobials using plumbing rings in an ex vivo porcine corneal infection model.
Foulkes, D. M., Mclean, K., Sharma, T., Fernig, D. G., & Kaye, S. B. (2025). Stable topical application of antimicrobials using plumbing rings in an ex vivo porcine corneal infection model.. PloS one, 20(4), e0319911. doi:10.1371/journal.pone.0319911
2024
Stable topical application of antimicrobials using plumbing rings in an<i>ex vivo</i>porcine corneal infection model
2023
Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity (vol 479, pg 2511, 2022)
Foulkes, D. M., McLean, K., Sloniecka, M., Rustidge, S., Byrne, D. P., Haneef, A. S., . . . Kaye, S. B. (2023). Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity (vol 479, pg 2511, 2022). BIOCHEMICAL JOURNAL, 480(7), 491-493. doi:10.1042/BCJ20220527_COR
2022
Impact of fluoroquinolones and aminoglycosides on<i> P.</i><i> aeruginosa</i> virulence factor production and
Foulkes, D. M., McLean, K., Sloniecka, M., Rustidge, S., Byrne, D. P., Haneef, A. S., . . . Kaye, S. B. (2022). Impact of fluoroquinolones and aminoglycosides on<i> P.</i><i> aeruginosa</i> virulence factor production and. BIOCHEMICAL JOURNAL, 479(24), 2511-2527. doi:10.1042/BCJ20220527
P-18 Impact of fluoroquinolones and aminoglycosides on P<i>. aeruginosa</i> virulence factor production and cytotoxicity.
Kaye, S., McLean, K., Foulkes, D. M., Sloniecka, M., Byrne, D., Haneef, A. S., . . . Fernig, D. G. (2022). P-18 Impact of fluoroquinolones and aminoglycosides on P<i>. aeruginosa</i> virulence factor production and cytotoxicity.. In BMJ open ophthalmology Vol. 7 (pp. A6). doi:10.1136/bmjophth-2022-bcm.15
A phospholipase assay screen identifies synergistic inhibitors of the <i>P. aeruginosa</i> toxin ExoU
2021
Bacterial keratitis: identifying the areas of clinical uncertainty
Tuft, S., Somerville, T. F., Li, J. -P. O., Neal, T., De, S., Horsburgh, M. J., . . . Kaye, S. (2021). Bacterial keratitis: identifying the areas of clinical uncertainty. Progress in Retinal and Eye Research, 101031. doi:10.1016/j.preteyeres.2021.101031
Impact of fluoroquinolones and aminoglycosides on <i>P. aeruginosa</i> virulence factor production and cytotoxicity
A pipeline to evaluate inhibitors of the <i>Pseudomonas</i> <i>aeruginosa</i> exotoxin U
Foulkes, D. M., McLean, K., Zheng, Y., Sarsby, J., Haneef, A. S., Fernig, D. G., . . . Kaye, S. B. (2021). A pipeline to evaluate inhibitors of the <i>Pseudomonas</i> <i>aeruginosa</i> exotoxin U. BIOCHEMICAL JOURNAL, 478(3), 647-668. doi:10.1042/BCJ20200780
2020
Evaluation of ExoU inhibitors in a<i>Pseudomonas aeruginosa</i>scratch infection assay
2019
<i>Pseudomonas aeruginosa</i> Toxin ExoU as a Therapeutic Target in the Treatment of Bacterial Infections
Foulkes, D. M., McLean, K., Haneef, A. S., Fernig, D. G., Winstanley, C., Berry, N., & Kaye, S. B. (2019). <i>Pseudomonas aeruginosa</i> Toxin ExoU as a Therapeutic Target in the Treatment of Bacterial Infections. MICROORGANISMS, 7(12). doi:10.3390/microorganisms7120707
Comb-like dextran copolymers: A versatile strategy to coat highly porous MOF nanoparticles with a PEG shell.
Cutrone, G., Qiu, J., Menendez-Miranda, M., Casas-Solvas, J. M., Aykaç, A., Li, X., . . . Gref, R. (2019). Comb-like dextran copolymers: A versatile strategy to coat highly porous MOF nanoparticles with a PEG shell.. Carbohydrate polymers, 223, 115085. doi:10.1016/j.carbpol.2019.115085
Combinatorial Drug Therapy: Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections (Part. Part. Syst. Charact. 3/2019)
Li, X., Semiramoth, N., Hall, S., Tafani, V., Josse, J., Laurent, F., . . . Gref, R. (2019). Combinatorial Drug Therapy: Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections (Part. Part. Syst. Charact. 3/2019). Particle & Particle Systems Characterization, 36(3). doi:10.1002/ppsc.201970009
Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections
Li, X., Semiramoth, N., Hall, S., Tafani, V., Josse, J., Laurent, F., . . . Gref, R. (2019). Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections. Particle & Particle Systems Characterization, 36(3). doi:10.1002/ppsc.201800360
2018
Biochemical analysis of Tribbles 2 pseudokinase using repurposed kinase inhibitors
Foulkes, D. M. (2018, September 28). Biochemical analysis of Tribbles 2 pseudokinase using repurposed kinase inhibitors.
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells
Foulkes, D. M., Byrne, D. P., Yeung, W., Shrestha, S., Bailey, F. P., Ferries, S., . . . Eyers, P. A. (2018). Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells. SCIENCE SIGNALING, 11(549), 14 pages. doi:10.1126/scisignal.aat7951
2017
Pseudokinases: update on their functions and evaluation as new drug targets
Byrne, D. P., Foulkes, D. M., & Eyers, P. A. (2017). Pseudokinases: update on their functions and evaluation as new drug targets. FUTURE MEDICINAL CHEMISTRY, 9(2), 245-265. doi:10.4155/fmc-2016-0207
2015
Tribbles pseudokinases: novel targets for chemical biology and drug discovery?
Foulkes, D. M., Byrne, D. P., Bailey, F. P., & Eyers, P. A. (2015). Tribbles pseudokinases: novel targets for chemical biology and drug discovery?. BIOCHEMICAL SOCIETY TRANSACTIONS, 43, 1095-1103. doi:10.1042/BST20150109