Research outputs
Selected research outputs
- An anti-biofilm cyclic peptide targets a secreted aminopeptidase from <i>P. aeruginosa</i> (Journal article - 2023)
- A rotary mechanism for allostery in bacterial hybrid malic enzymes (Journal article - 2021)
- A lysozyme with altered substrate specificity facilitates prey cell exit by the periplasmic predator <i>Bdellovibrio bacteriovorus</i> (Journal article - 2020)
2025
Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament
Sutherland, E., Harding, C. J., de Bergendal, T. D. M., Florence, G. J., Ackermann, K., Bode, B. E., . . . Czekster, C. M. (2025). Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament. NATURE COMMUNICATIONS, 16(1). doi:10.1038/s41467-025-56127-y
Improved Nucleoside (2'-Deoxy)Ribosyltransferases Maximize Enzyme Promiscuity while Maintaining Catalytic Efficiency.
Tang, P., Zickuhr, G. M., Dickson, A. L., Harding, C. J., Devi, S., Lebl, T., . . . Czekster, C. M. (2025). Improved Nucleoside (2'-Deoxy)Ribosyltransferases Maximize Enzyme Promiscuity while Maintaining Catalytic Efficiency.. ACS chemical biology, 20(11), 2547-2553. doi:10.1021/acschembio.5c00120
2024
Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament
Snapshots of the Reaction Coordinate of a Thermophilic 2′-Deoxyribonucleoside/ribonucleoside Transferase
Tang, P., Harding, C. J., Dickson, A. L., da Silva, R. G., Harrison, D. J., & Czekster, C. M. (2024). Snapshots of the Reaction Coordinate of a Thermophilic 2′-Deoxyribonucleoside/ribonucleoside Transferase. ACS CATALYSIS, 14(5), 3090-3102. doi:10.1021/acscatal.3c06260
2023
Unveiling the Catalytic Mechanism of a Processive Metalloaminopeptidase
Simpson, M. C., Harding, C. J., Czekster, R. M., Remmel, L., Bode, B. E., & Czekster, C. M. (2023). Unveiling the Catalytic Mechanism of a Processive Metalloaminopeptidase. BIOCHEMISTRY, 62(22), 3188-3205. doi:10.1021/acs.biochem.3c00420
An anti-biofilm cyclic peptide targets a secreted aminopeptidase from <i>P. aeruginosa</i>
Harding, C. J., Bischoff, M., Bergkessel, M., & Czekster, C. M. (2023). An anti-biofilm cyclic peptide targets a secreted aminopeptidase from <i>P. aeruginosa</i>. NATURE CHEMICAL BIOLOGY, 19(9). doi:10.1038/s41589-023-01373-8
2022
Active site remodelling of a cyclodipeptide synthase redefines substrate scope
Sutherland, E., Harding, C. J., & Czekster, C. M. (2022). Active site remodelling of a cyclodipeptide synthase redefines substrate scope. COMMUNICATIONS CHEMISTRY, 5(1). doi:10.1038/s42004-022-00715-2
2021
A rotary mechanism for allostery in bacterial hybrid malic enzymes
Harding, C. J., Cadby, I. T., Moynihan, P. J., & Lovering, A. L. (2021). A rotary mechanism for allostery in bacterial hybrid malic enzymes. NATURE COMMUNICATIONS, 12(1). doi:10.1038/s41467-021-21528-2
Bypassing the requirement for aminoacyl-tRNA by a cyclodipeptide synthase enzyme
Harding, C. J., Sutherland, E., Hanna, J. G., Houston, D. R., & Czekster, C. M. (2021). Bypassing the requirement for aminoacyl-tRNA by a cyclodipeptide synthase enzyme. RSC CHEMICAL BIOLOGY, 2(1), 230-240. doi:10.1039/d0cb00142b
2020
A lysozyme with altered substrate specificity facilitates prey cell exit by the periplasmic predator <i>Bdellovibrio bacteriovorus</i>
Harding, C. J., Huwiler, S. G., Somers, H., Lambert, C., Ray, L. J., Till, R., . . . Lovering, A. L. (2020). A lysozyme with altered substrate specificity facilitates prey cell exit by the periplasmic predator <i>Bdellovibrio bacteriovorus</i>. NATURE COMMUNICATIONS, 11(1). doi:10.1038/s41467-020-18139-8
2019
Target highlights in CASP13: Experimental target structures through the eyes of their authors
Lepore, R., Kryshtafovych, A., Alahuhta, M., Veraszto, H. A., Bomble, Y. J., Bufton, J. C., . . . Schwede, T. (2019). Target highlights in CASP13: Experimental target structures through the eyes of their authors. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 87(12), 1037-1057. doi:10.1002/prot.25805
Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system
Hughes, G. W., Hall, S. C. L., Laxton, C. S., Sridhar, P., Mahadi, A. H., Hatton, C., . . . Knowles, T. J. (2019). Evidence for phospholipid export from the bacterial inner membrane by the Mla ABC transport system. NATURE MICROBIOLOGY, 4(10), 1692-1705. doi:10.1038/s41564-019-0481-y