Research outputs
2024
Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment
Rengifo Rojas, C., Cercy, J., Perillous, S., Gonthier-Guéret, C., Montibus, B., Maupetit-Méhouas, S., . . . Court, F. (2024). Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment. Human Genetics and Genomics Advances, 5(2), 100271. doi:10.1016/j.xhgg.2024.100271
Microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in Trappc9 KO mice
Aljuraysi, S., Platt, M., Pulix, M., Poptani, H., & Plagge, A. (2024). Microcephaly with a disproportionate hippocampal reduction, stem cell loss and neuronal lipid droplet symptoms in Trappc9 KO mice. Neurobiology of Disease, 106431. doi:10.1016/j.nbd.2024.106431
Maternal <i>GNAS</i> contributes to the extra-large G protein α-subunit (XLαs) expression in a cell type-specific manner (vol 12, 680537, 2021)
Cui, Q., Aksu, C., Ay, B., Remillard, C. E., Plagge, A., Gardezi, M., . . . Bastepe, M. (2024). Maternal <i>GNAS</i> contributes to the extra-large G protein α-subunit (XLαs) expression in a cell type-specific manner (vol 12, 680537, 2021). FRONTIERS IN GENETICS, 15. doi:10.3389/fgene.2024.1372003
2023
2022
Variable allelic expression of imprinted genes at the Peg13, Trappc9, Ago2 cluster in single neural cells
Claxton, M., Pulix, M., Seah, M. K. Y., Bernardo, R., Zhou, P., Aljuraysi, S., . . . Plagge, A. (2022). Variable allelic expression of imprinted genes at the Peg13, Trappc9, Ago2 cluster in single neural cells. Frontiers in Cell and Developmental Biology, 10. doi:10.3389/fcell.2022.1022422
Firefly luciferase offers superior performance to AkaLuc for tracking the fate of administered cell therapies
Amadeo, F., Plagge, A., Chacko, A., Wilm, B., Hanson, V., Liptrott, N., . . . Taylor, A. (2022). Firefly luciferase offers superior performance to AkaLuc for tracking the fate of administered cell therapies. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 49(3), 796-808. doi:10.1007/s00259-021-05439-4
Trappc9 deficiency in mice recapitulates human disorder of microcephaly and obesity, which is associated with lipid droplet abnormalities in neurons.
Aljuraysi, S., Pulix, M., Sellin, A., & Plagge, A. (2022). Trappc9 deficiency in mice recapitulates human disorder of microcephaly and obesity, which is associated with lipid droplet abnormalities in neurons.. In ACTA PHYSIOLOGICA Vol. 236 (pp. 499). Retrieved from https://www.webofscience.com/
2021
NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions
Sutton, E., Early, J., Hughes, A., Gall, L., Carter, A., Copple, I., . . . Pekovic-Vaughan, V. (2021). NRF2/KEAP1 pathway is required to fine-tune circadian oscillations as part of the negative feedback loop of the molecular clock: implications for tissue homeostasis and therapeutic interventions. In FREE RADICAL BIOLOGY AND MEDICINE Vol. 177. doi:10.1016/j.freeradbiomed.2021.08.042
Maternal GNAS Contributes to the Extra-Large G Protein α-Subunit (XLαs) Expression in a Cell Type-Specific Manner
Cui, Q., Aksu, C., Ay, B., Remillard, C. E., Plagge, A., Gardezi, M., . . . Bastepe, M. (2021). Maternal GNAS Contributes to the Extra-Large G Protein α-Subunit (XLαs) Expression in a Cell Type-Specific Manner. Frontiers in Genetics, 12. doi:10.3389/fgene.2021.680537
2020
Assessing Human Embryonic Stem Cell-Derived Dopaminergic Neuron Progenitor Transplants Using Non-invasive Imaging Techniques
Hill, C. (2020). Assessing Human Embryonic Stem Cell-Derived Dopaminergic Neuron Progenitor Transplants Using Non-invasive Imaging Techniques. Molecular Imaging and Biology. doi:10.1007/s11307-020-01499-4
Extra-large Gα protein (XLαs) deficiency causes severe adenine-induced renal injury with massive FGF23 elevation
Matthias, J., Cui, Q., Shumate, L. T., Plagge, A., He, Q., & Bastepe, M. (2020). Extra-large Gα protein (XLαs) deficiency causes severe adenine-induced renal injury with massive FGF23 elevation. Endocrinology, 161(01), 1-15. doi:10.1210/endocr/bqz025
Imprinted Genes and Hypothalamic Function
Pulix, M., & Plagge, A. (2020). Imprinted Genes and Hypothalamic Function. In Masterclass in Neuroendocrinology (pp. 265-294). Springer International Publishing. doi:10.1007/978-3-030-40002-6_10
2019
Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria
Hughes, J. H., Liu, K., Plagge, A., Wilson, P. J. M., Sutherland, H., Norman, B. P., . . . Bou-Gharios, G. (2019). Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria. Human Molecular Genetics, 28(23), 3928-3939. doi:10.1093/hmg/ddz234
A G protein-coupled, IP3/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23
He, Q., Shumate, L. T., Matthias, J., Aydin, C., Wein, M. N., Spatz, J. M., . . . Bastepe, M. (2019). A G protein-coupled, IP3/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23. JCI INSIGHT, 4(17). doi:10.1172/jci.insight.125007
MON-LB087 Synthesis of Osteocyte-Derived Phosphaturic Hormone FGF23 via IP3/PKC Signaling Downstream of the Extra-Large Gα Subunit (XLαs)
He, Q., Shumate, L., Matthias, J., Aydin, C., Wein, M., Spatz, J., . . . Bastepe, M. (2019). MON-LB087 Synthesis of Osteocyte-Derived Phosphaturic Hormone FGF23 via IP3/PKC Signaling Downstream of the Extra-Large Gα Subunit (XLαs). Journal of the Endocrine Society, 3(Supplement_1). doi:10.1210/js.2019-mon-lb087
2018
Multicolour In Vivo Bioluminescence Imaging Using a NanoLuc‐Based BRET Reporter in Combination with Firefly Luciferase
TAYLOR, A., Sharkey, J., Plagge, A. J., Wilm, B., & Murray, P. (2018). Multicolour In Vivo Bioluminescence Imaging Using a NanoLuc‐Based BRET Reporter in Combination with Firefly Luciferase. Contrast Media and Molecular Imaging, 2018. doi:10.1155/2018/2514796
Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes.
Comenge, J., Sharkey, J., Fragueiro, O., Wilm, B., Brust, M., Murray, P., . . . Plagge, A. (2018). Multimodal cell tracking from systemic administration to tumour growth by combining gold nanorods and reporter genes.. eLife, 7. doi:10.7554/elife.33140
Functional comparison of distinct Brachyury+ states in a renal differentiation assay.
Zhou, J., Plagge, A., & Murray, P. (2018). Functional comparison of distinct Brachyury+ states in a renal differentiation assay.. Biology open, 7. doi:10.1242/bio.031799
Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors
Bantounas, I., Ranjzad, P., Tengku, F., Silajdzic, E., Forster, D., Asselin, M. -C., . . . Kimber, S. J. (2018). Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors. Stem Cell Reports, 10(3), 766-779. doi:10.1016/j.stemcr.2018.01.008
Assessing the Effectiveness of a Far-Red Fluorescent Reporter for Tracking Stem Cells In Vivo
Zhou, J., Sharkey, J., Shukla, R., Plagge, A., & Murray, P. (2018). Assessing the Effectiveness of a Far-Red Fluorescent Reporter for Tracking Stem Cells In Vivo. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 19(1). doi:10.3390/ijms19010019
2017
Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo
He, Q., Bouley, R., Liu, Z., Wein, M. N., Zhu, Y., Spatz, J. M., . . . Bastepe, M. (2017). Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo. Proceedings of the National Academy of Sciences of USA, 114(45), E9559-E9568. doi:10.1073/pnas.1712670114
INVESTIGATIONS INTO THE FUNCTIONS AND REGULATION OF THE MICROCEPHALY-ASSOCIATED TRAPPC9 GENE.
Pulix, M. (2017, April 13). INVESTIGATIONS INTO THE FUNCTIONS AND REGULATION OF THE MICROCEPHALY-ASSOCIATED TRAPPC9 GENE.. (University of Liverpool).
2016
Impulsive choices in mice lacking imprinted Nesp55
Dent, C. L., Humby, T., Lewis, K., Plagge, A., Fischer-Colbrie, R., Wilkins, J. F., . . . Isles, A. R. (2016). Impulsive choices in mice lacking imprinted Nesp55. Genes, Brain and Behavior, 15(8), 693-701. doi:10.1111/gbb.12316
Reductions in hypothalamic Gfap expression, glial cells and α-tanycytes in lean and hypermetabolic Gnasxl-deficient mice
Holmes, A. P., Wong, S. Q., Pulix, M., Johnson, K., Horton, N. S., Thomas, P., . . . Plagge, A. (2016). Reductions in hypothalamic Gfap expression, glial cells and α-tanycytes in lean and hypermetabolic Gnasxl-deficient mice. Molecular Brain, 9(1), 1-13. doi:10.1186/s13041-016-0219-1
2015
The G protein α subunit variant XLαs promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo
He, Q., Zhu, Y., Corbin, B. A., Plagge, A., & Bastepe, M. (2015). The G protein α subunit variant XLαs promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo. Science Signaling, 8(391). doi:10.1126/scisignal.aaa9953
2013
Gene Dosage Effects at the Imprinted <i>Gnas</i> Cluster
Ball, S. T., Kelly, M. L., Robson, J. E., Turner, M. D., Harrison, J., Jones, L., . . . Peters, J. (2013). Gene Dosage Effects at the Imprinted <i>Gnas</i> Cluster. PLOS ONE, 8(6). doi:10.1371/journal.pone.0065639
Elevated blood pressure, heart rate and body temperature in mice lacking the XLαs protein of the <i>Gnas</i> locus is due to increased sympathetic tone
Nunn, N., Feetham, C. H., Martin, J., Barrett-Jolley, R., & Plagge, A. (2013). Elevated blood pressure, heart rate and body temperature in mice lacking the XLαs protein of the <i>Gnas</i> locus is due to increased sympathetic tone. EXPERIMENTAL PHYSIOLOGY, 98(10), 1432-1445. doi:10.1113/expphysiol.2013.073064
2012
Non-Coding RNAs at the Gnas and Snrpn-Ube3a Imprinted Gene Loci and Their Involvement in Hereditary Disorders.
Plagge, A. (2012). Non-Coding RNAs at the Gnas and Snrpn-Ube3a Imprinted Gene Loci and Their Involvement in Hereditary Disorders.. Frontiers in genetics, 3, 264. doi:10.3389/fgene.2012.00264
Loss of XLαs (extra-large αs) imprinting results in early postnatal hypoglycemia and lethality in a mouse model of pseudohypoparathyroidism Ib
Fernandez-Rebollo, E., Maeda, A., Reyes, M., Turan, S., Froehlich, L. F., Plagge, A., . . . Bastepe, M. (2012). Loss of XLαs (extra-large αs) imprinting results in early postnatal hypoglycemia and lethality in a mouse model of pseudohypoparathyroidism Ib. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 109(17), 6638-6643. doi:10.1073/pnas.1117608109
Postnatal Changes in the Expression Pattern of the Imprinted Signalling Protein XLαs Underlie the Changing Phenotype of Deficient Mice
Krechowec, S. O., Burton, K. L., Newlaczyl, A. U., Nunn, N., Vlatkovic, N., & Plagge, A. (2012). Postnatal Changes in the Expression Pattern of the Imprinted Signalling Protein XLαs Underlie the Changing Phenotype of Deficient Mice. PLOS ONE, 7(1). doi:10.1371/journal.pone.0029753
'Functions of non-coding RNAs at imprinted gene loci'
Plagge, A. (2012). 'Functions of non-coding RNAs at imprinted gene loci'. Frontiers in Epigenomics. Retrieved from http://www.frontiersin.org/
Investigation of the expression pattern and functional importance of the Gnasxl-encoded XLαs protein of the imprinted Gnas Locus
Burton, K. (2012). Investigation of the expression pattern and functional importance of the Gnasxl-encoded XLαs protein of the imprinted Gnas Locus.
2011
Development of a conditional knock-out for XLαs; A G-protein-like signalling molecule encoded by the imprinted <i>Gnas</i> locus
Krechowec, S., & Plagge, A. (2011). Development of a conditional knock-out for XLαs; A G-protein-like signalling molecule encoded by the imprinted <i>Gnas</i> locus. GENETICS RESEARCH, 93(6), 435. Retrieved from https://www.webofscience.com/
2010
Development of a Tissue-Specific Knock-Out Model for XLαs; A Signalling Protein Involved in the Regulation of Body Weight, Adiposity and Energy Expenditure
Krechowec, S. O., & Plagge, A. (2010). Development of a Tissue-Specific Knock-Out Model for XLαs; A Signalling Protein Involved in the Regulation of Body Weight, Adiposity and Energy Expenditure. OBESITY, 18, S81. Retrieved from https://www.webofscience.com/
2009
GNAS Haploinsufficiency Leads to Subcutaneous Tumor Formation With Collagen and Elastin Deposition and Calcification
Sakamoto, A., Weinstein, L. S., Plagge, A., Eckhaus, M., & Kelsey, G. (2009). GNAS Haploinsufficiency Leads to Subcutaneous Tumor Formation With Collagen and Elastin Deposition and Calcification. ENDOCRINE RESEARCH, 34(1-2), 1-9. doi:10.1080/07435800902841280
2008
Characterization of a novel obesity phenotype caused by interspecific hybridization.
Singh, U., Rizvi, F., Yu, Y., Shi, W., Orth, A., Karimi, M., . . . Fundele, R. (2008). Characterization of a novel obesity phenotype caused by interspecific hybridization.. Archives of physiology and biochemistry, 114(5), 301-330. doi:10.1080/13813450802542495
Imprinted genes, postnatal adaptations and enduring effects on energy homeostasis
Frontera, M., Dickins, B., Plagge, A., & Kelsey, G. (2008). Imprinted genes, postnatal adaptations and enduring effects on energy homeostasis. GENOMIC IMPRINTING, 626, 41-61. Retrieved from https://www.webofscience.com/
Physiological dysfunctions associated with mutations of the imprinted Gnas locus
Krechowec, S., & Plagge, A. (2008). Physiological dysfunctions associated with mutations of the imprinted Gnas locus. PHYSIOLOGY, 23(4), 221-229. doi:10.1152/physiol.00010.2008
Physiological functions of the imprinted <i>Gnas</i> locus and its protein variants Gα<sub>s</sub> and XLα<sub>s</sub> in human and mouse
Plagge, A., Kelsey, G., & Germain-Lee, E. L. (2008). Physiological functions of the imprinted <i>Gnas</i> locus and its protein variants Gα<sub>s</sub> and XLα<sub>s</sub> in human and mouse. JOURNAL OF ENDOCRINOLOGY, 196(2), 193-214. doi:10.1677/JOE-07-0544
2006
The alternative stimulatory G protein α-subunit XLαs is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice
Xie, T., Plagge, A., Gavrilova, O., Pack, S., Jou, W., Lai, E. W., . . . Weinstein, L. S. (2006). The alternative stimulatory G protein α-subunit XLαs is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice. JOURNAL OF BIOLOGICAL CHEMISTRY, 281(28), 18989-18999. doi:10.1074/jbc.M511752200
Identification of an imprinting control region affecting the expression of all transcripts in the <i>Gnas</i> cluster
Williamson, C. M., Turner, M. D., Ball, S. T., Nottingham, W. T., Glenister, P., Fray, M., . . . Peters, J. (2006). Identification of an imprinting control region affecting the expression of all transcripts in the <i>Gnas</i> cluster. NATURE GENETICS, 38(3), 350-355. doi:10.1038/ng1731
Imprinting the <i>Gnas</i> locus
Plagge, A., & Kelsey, G. (2006). Imprinting the <i>Gnas</i> locus. CYTOGENETIC AND GENOME RESEARCH, 113(1-4), 178-187. doi:10.1159/000090830
Imprinted genes, postnatal adaptations and enduring effects on energy homeostasis
Frontera, M., Dickins, B., Plagge, A., & Kelsey, G. (2006). Imprinted genes, postnatal adaptations and enduring effects on energy homeostasis. In J. Wilkins (Ed.), Genomic Imprinting (pp. 1-10). Georgetown: Landes Bioscience. Retrieved from http://www.landesbioscience.com/books/intelligence_unit/id/945
2005
Imprinted Nesp55 influences behavioral reactivity to novel environments
Plagge, A., Isles, A. R., Gordon, E., Humby, T., Dean, W., Gritsch, S., . . . Kelsey, G. (2005). Imprinted Nesp55 influences behavioral reactivity to novel environments. MOLECULAR AND CELLULAR BIOLOGY, 25(8), 3019-3026. doi:10.1128/MCB.25.8.3019-3026.2005
Reciprocal imprinting and functioning of two gene products from the <i>Gnas</i> locus:: XLαs and Gsα
Dickins, B., Plagge, A., Weinstein, L., & Kelsey, G. (2005). Reciprocal imprinting and functioning of two gene products from the <i>Gnas</i> locus:: XLαs and Gsα. GENETICAL RESEARCH, 86(3), 236. Retrieved from https://www.webofscience.com/
2004
A <i>cis</i>-acting control region is required exclusively for the tissue-specific imprinting of <i>Gnas</i>
Williamson, C. M., Ball, S. T., Nottingham, W. T., Skinner, J. A., Plagge, A., Turner, M. D., . . . Peters, J. (2004). A <i>cis</i>-acting control region is required exclusively for the tissue-specific imprinting of <i>Gnas</i>. NATURE GENETICS, 36(8), 894-899. doi:10.1038/ng1398
The imprinted signaling protein XLαs is required for postnatal adaptation to feeding
Plagge, A., Gordon, E., Dean, W., Boiani, R., Cinti, S., Peters, J., & Kelsey, G. (2004). The imprinted signaling protein XLαs is required for postnatal adaptation to feeding. NATURE GENETICS, 36(8), 818-826. doi:10.1038/ng1397
2001
The contactin-related protein FAR-2 defines Purkinje cell clusters and labels subpopulations of climbing fibers in the developing cerebellum
Plagge, A., Sendtner-Voelderndorff, L., Sirim, P., Freigang, J., Rader, C., Sonderegger, P., & Brümmendorf, T. (2001). The contactin-related protein FAR-2 defines Purkinje cell clusters and labels subpopulations of climbing fibers in the developing cerebellum. MOLECULAR AND CELLULAR NEUROSCIENCE, 18(1), 91-107. doi:10.1006/mcne.2001.1006
2000
Analysis of mutant D3 dopamine receptors <i>in vitro</i>, and D3 receptor neuron development <i>in vivo</i>.
Heitz, F., Plagge, A., McAllister, G., Ragan, I., & Allen, N. (2000). Analysis of mutant D3 dopamine receptors <i>in vitro</i>, and D3 receptor neuron development <i>in vivo</i>.. EUROPEAN JOURNAL OF NEUROSCIENCE, 12, 403. Retrieved from https://www.webofscience.com/
Zebra stripes in the cerebellum:: Identification of a neurite outgrowth related protein expressed in sagittal zones in the cerebellar cortex.
Plagge, A., Sendtner-Voelderndorff, L., Sirim, P., Rader, C., Sonderegger, P., & Brümmendorf, T. (2000). Zebra stripes in the cerebellum:: Identification of a neurite outgrowth related protein expressed in sagittal zones in the cerebellar cortex.. EUROPEAN JOURNAL OF NEUROSCIENCE, 12, 276. Retrieved from https://www.webofscience.com/
1999
Directed mutagenesis in embryonic stem cells
Plagge, A., Kelsey, G., & Allen, N. D. (1999). Directed mutagenesis in embryonic stem cells. In Mouse Genetics and Transgenics (pp. 247-284). Oxford University PressOxford. doi:10.1093/oso/9780199637096.003.0011
Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP
Marg, A., Sirim, P., Spaltmann, F., Plagge, A., Kauselmann, G., Buck, F., . . . Brümmendorf, T. (1999). Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP. JOURNAL OF CELL BIOLOGY, 145(4), 865-876. doi:10.1083/jcb.145.4.865
IG superfamily molecules in neurohistogenesis:: From the analysis of axon elongation to hereditary malformations of axon tracts
Brümmendorf, T., Marg, A., De Angelis, E., Sirim, P., Plagge, A., MacFarlane, J., . . . Rathjen, F. G. (1999). IG superfamily molecules in neurohistogenesis:: From the analysis of axon elongation to hereditary malformations of axon tracts. JOURNAL OF NEUROCHEMISTRY, 73, S110. Retrieved from https://www.webofscience.com/
1997
The gene of the neural cell recognition molecule F11: Conserved exon-intron arrangement in genes of neural members of the immunoglobulin superfamily
Plagge, A., & Brummendorf, T. (1997). The gene of the neural cell recognition molecule F11: Conserved exon-intron arrangement in genes of neural members of the immunoglobulin superfamily. GENE, 192(2), 215-225. doi:10.1016/S0378-1119(97)00066-8
1996
Epitope mapping on extracellular domains of cell-surface proteins using exonuclease III.
Brümmendorf, T., Plagge, A., & Treubert, U. (1996). Epitope mapping on extracellular domains of cell-surface proteins using exonuclease III.. Methods in molecular biology (Clifton, N.J.), 66, 319-342. doi:10.1385/0-89603-375-9:319